Medicine and Health Sciences Commons^™

Fiber Modification Of Adenoviral Vectors For Cancer Gene Therapy, Miho Murakami

All ETDs from UAB

Cancer still remains a major public health concern despite improvements in primary prevention, early detection and advanced treatments. Cancer gene therapy using human adenovirus serotype 5 (HAdV-5) as a vector has been explored as a new therapeutic approach. HAdV-5 infection is initiated by binding to the coxsackie virus and adenovirus receptor (CAR), its primary cellular receptor. However, the levels and patterns of expression of CAR vary greatly in clinical tumor tissue samples, and the expression lev-els tend to decrease as the tumors progress. The low level expression of CAR in target cancer cells diminishes the utility of HAdV-5 as a …

Organizational Support, Perceived Social Support, And Intent To Turnover Among Psychiatric Nurses: A Mixed Methods Study., Beverly Jean Myers

All ETDs from UAB

Nurse turnover compromises the quality of patient care and leads to an increase in organizational costs. Nurse turnover is defined as the intent to leave one's current job position either to transfer to another unit within the organization or to terminate employment with the organization. Few studies have examined the role social support received at work as well as at home, personal characteristics and work factors play in guiding psychiatric nurses' decisions to leave a current nursing position (turnover). The overall purpose of this mixed-methods sequential explanatory study was to explore factors that contribute to psychiatric nurses' intent to turnover. …

Occupational Stress, Job Satisfaction And Job Performance Among Hospital Nurses In Kampala Uganda, Rose Chalo Nabirye

All ETDs from UAB

ABSTRACT Occupational stress, a common occurrence among various professions worldwide, is regarded as a major occupational health problem for healthcare professionals especially nurses. Occupational stress has been reported to affect job satisfaction and job performance among nurses, thus compromising nursing care and placing patients' lives at risk. Stress is a complex phenomenon resulting from the interaction between individuals and the environment. Therefore, significant differences in occupational stress, job satisfaction and job performance among nurses may exist due to different work settings. The aims of the study were to: 1) examine the relationships between occupational stress, job satisfaction and job performance …

Poxvirus Evolution: The Role Of Horizontal Gene Transfer, Mary Rebecca Odom

All ETDs from UAB

We have investigated the set of all poxvirus proteins for information about the origins of protein coding genes of the Poxviridae family of viruses. A global assessment of all poxvirus proteins for levels of similarity to proteins of other organisms, including eukaryotes, viruses, and prokaryotes, has suggested trends and relationships informative about poxvirus evolution and poxvirus interactions with hosts. Our research has focused on the poxvirus proteins subset this assessment identified as likely to have evolutionary histories involving horizontal gene transfer (HGT). We have used phylogenetic reconstructions to individually determine the sources of more than 70 horizontally transferred genes present …

The Transition Zone: Impact Of Riverbanks On Emergent Dragonfly Nymphs. Implications For Riverbank Restoration And Management, Kirsten Hope Martin

Antioch University Dissertations & Theses

The use of riprap in the restoration and stabilization of riverine landscapes is an issue of concern for many ecologists. While current methods of bank stabilization, especially those involving the placement of rocks (riprap) along the waterline, are effective in controlling erosion their presence changes habitat components (slope, substrate composition, near-shore river velocity) at the river-land interface. The additional impacts of river current, water temperature, soil composition, slope, and water level fluctuation, may further imperil emerging nymphs. The purpose of this research is to document the effects of riprap, location (upriver or downriver of hydroelectric intake/outtake facilities), water level fluctuation, …

Female Humpback Whale (Megaptera Novaeangliae) Reproductive Class And Male-Female Interactions During The Breeding Season, Meagan E. Jones

Antioch University Dissertations & Theses

This study examined whether female reproductive class (i.e., presence or absence of a calf) in humpback whales (Megaptera novaeangliae) affects female behavior and male-female interactions on the Hawaiian breeding grounds. From 2003-2008, 295 female-calf groups (with or without a male escort) and 256 female no-calf groups (with a male) were observed. Forty-one female no-calf groups were confirmed male-female pairs by genetic sexing or photo-identification. Focal follows of 36 male-female pairs and 50 female-calf groups (29 escorted and 21 unescorted female-calf groups) were analyzed for time budget and movement estimates. Relative fluke size (fluke photogrammetry, n=30) and sighting histories …

Patient Factors In The Selection Of Operative Versus Nonoperative Treatment For Posterior Tibial Tendon Dysfunction, Kathryn O'Connor, Judith Baumhauer, Jeff R. Houck

Faculty Publications - College of Physical Therapy

Background: The influence of demographic, medical history, and treatment variables on the maintenance of nonoperative care or progression to operative intervention in Posterior Tibial Tendon Dysfuction (PTTD) was explored. This retrospective study compared demographic, medical history and treatment variables between operative and nonoperative care in subjects with PTTD.

Materials and Methods: Charts with the ICD-9 codes (726.72, 726.90) and brace distribution records for 2005 and 2006 were used to identify subjects. From these, 166 of 606 charts included documentation of PTTD. Variables were grouped into three categories including demographics (Age, body mass index, gender and working status), medical (stage, symptom …

The Effect Of Encounters Between Medical Gatekeepers And Patients On The Doctor-Patient Relationship, Linda Pilzer Erlich

Walden Dissertations and Doctoral Studies

Research currently indicates patient perceptions of the doctor-patient relationship are central to health outcomes. Theoretically, the current study is grounded in two literatures: the placebo effect and the broader literature examining empirically tested predictors of the doctor-patient relationship. Two factors not yet studied relative to patient perceptions of the doctor-patient relationship include the direct effect of medical gatekeeper characteristics along with the interaction between gatekeeper characteristics and existing healthcare attitudes/behaviors. This quantitative archival study utilized a MultiCare Survey dataset of 10, 579 participants who were general practitioner patients in northwestern United States. This study first examined the individual impact of …

Fdg-Pet Staging And Importance Of Lymph Node Suv In Head And Neck Cancer., Gregory J Kubicek, Collin Champ, Shannon Fogh, Fen Wang, Eashwer Reddy, Charles Intenzo, Reginald W Dusing, Mitchell Machtay

Department of Radiation Oncology Faculty Papers

OBJECTIVES: The role of positron emission tomography (PET) with fluoro-deoxy-glucose (FDG) in the staging of head and neck cancer (HNC) is unclear. The NCCN guidelines do not recommend FDG-PET as a part of standard workup. The purpose of this report is to examine the role of FDG-PET imaging in altering management and providing prognostic information for HNC.

METHODS: Retrospective review of HNC patients who had a staging FDG-PET scan performed at either Thomas Jefferson University or University of Kansas Medical Center between the years 2001 and 2007. A total of 212 PET scans were performed in patients who went on …

Evaluating Children With Otitis Media For Bacteremia Or Urinary Tract Infection., Daniel Yawman, Patrick Mahar, Aaron Blumkin, Gregory P. Conners

Manuscripts, Articles, Book Chapters and Other Papers

Background. It is unclear if clinicians evaluate for concurrent bacteremia or UTI in young patients diagnosed with acute otitis media (AOM). Objectives. To describe how often, and under which circumstances, emergency providers investigate for bacteremia or UTI in 2-36 month olds with AOM. Methods. Cases of AOM were analyzed from the 2001-2004 National Hospital Ambulatory Medical Care Survey (NHAMCS)-Emergency Department dataset. Results. AOM was diagnosed in 17% of the 10,847 recorded visits of 2-36 month olds. Of these visits, laboratory testing included: CBC: 7%, Blood culture: 4%, urinalysis or urine culture: 5%, and any of these tests: 9%. Rates of …

Clinico-Morphological Correlations In The Categorization Of Holes Between The Ventricles., Brad A. Friedman, Anthony Hlavacek, Karen Chessa, Girish S. Shirali, Eowyn Corcrain, Diane Spicer, Robert H. Anderson, Sinai Zyblewski

Manuscripts, Articles, Book Chapters and Other Papers

Controversy still exists in the categorization of holes between the ventricles, although they are the most common congenital cardiac malformation. Advanced imaging techniques such as three-dimensional echocardiography and computed tomographic angiography offer superb anatomical details of these defects. In this review, we have sought to collate the features highlighted in different categorizations and identify their similarities, but also emphasize their differences. We hope that an analysis of this type, now achievable during life, using advanced imaging, might lead to the appearance of a unified system for diagnosis and description of holes between the ventricles.

Sources Of Variability In Iso-Inertial Jump Assessments, Kristie-Lee Taylor, John Cronin, Nicholas Gill, Dale Chapman, Jeremy Sheppard

Research outputs pre 2011

Purpose: This investigation aimed to quantify the typical variation for kinetic and kinematic variables measured during loaded jump squats. Methods: Thirteen professional athletes performed six maximal effort countermovement jumps on fouroccasions. Testing occurred over 2 d, twice per day (8 AM and 2 PM) separated by 7 d, with the same procedures replicated on each occasion. Jump height, peak power (PP), relative peak power (RPP), mean power (MP), peak velocity (PV), peak force (PF), mean force (MF), and peak rate of force development (RFD) measurements were obtained from a linear optical encoder attached to a 40 kg barbell. Results: A …

Living Well With Diabetes: A Randomized Controlled Trial Of A Telephone-Delivered Intervention For Maintenance Of Weight Loss, Physical Activity And Glycaemic Control In Adults With Type 2 Diabetes, Elizabteh Eakin, Marina Reeves, Alison Marshall, David Dunstan, Nicholas Graves, Genevieve Healy, Jonathan Bleier, Adrian Barnett, Trisha O'Moore-Sullivan, Anthony Russell, Ken Wilkie

Research outputs pre 2011

Background By 2025, it is estimated that approximately 1.8 million Australian adults (approximately 8.4% of the adult population) will have diabetes, with the majority having type 2 diabetes. Weight management via improved physical activity and diet is the cornerstone of type 2 diabetes management. However, the majority of weight loss trials in diabetes have evaluated short-term, intensive clinic-based interventions that, while producing short-term outcomes, have failed to address issues of maintenance and broad population reach. Telephone-delivered interventions have the potential to address these gaps. Methods/Design Using a two-arm randomised controlled design, this study will evaluate an 18-month, telephone-delivered, behavioural weight …

Testing An Exergame For Effectiveness And Attractiveness, Jeffrey Ronald Sinclair, Philip Hingston, Martin Masek, Kazunori Nosaka

Research outputs pre 2011

In this paper, we report on an experimental study in which we investigated the use of feedback mechanisms in exergames. We based the study around the Dual Flow model for exergame design, using biophysical feedback to control exercise intensity, and player performance feedback to control gameplay challenge. We found good success in controlling exercise intensity to achieve an effective workout, while controlling gameplay challenge to improve enjoyment and attractiveness was problematic. We offer some possible reasons for this, suggesting the need for further investigation.

Aging, The Urban-Rural Gap And Disability Trends: 19 Years Of Experience In China - 1987 To 2006, Xiaoxia Peng, Shige Song, Sheena Sullivan, Jingjun Qiu, Wei Wang

Research outputs pre 2011

As the age of a population increases, so too does the rate of disability. In addition, disability is likely to be more common in rural compared with urban areas. The present study aimed to examine the influence of rapid population changes in terms of age and rural/urban residence on the prevalence of disability. Data from the 1987 and 2006 China Sampling Surveys on Disability were used to estimate the impacts of rapid ageing and the widening urban-rural gap on the prevalence of disability. Stratum specific rates of disability were estimated by 5-year age-group and type of residence. The decomposition of …

A Zebrafish Melanophore Model Of Amyloid (Beta) Toxicity, Morgan Newman, Lachlan Wilson, Esther Camp, Giuseppe Verdile, Ralph Martins, Michael Lardelli

Research outputs pre 2011

Reliable animal models are required to facilitate the understanding of neurodegenerative pathways in Alzheimer’s disease. Animal models can also be employed to search for disease-modifying drugs. The embryos and larvae of zebrafish are particularly advantageous for this purpose. For Alzheimer’s disease, drugs that can ameliorate amyloidb (Ab) toxicity have therapeutic and=or prophylactic potential. We attempted to generate a zebrafish model of Ab toxicity that would be viable and fertile but have a highly visible pigmentation phenotype in larvae. The larvae could then be arrayed in microtiter plates to screen compound libraries for drugs acting to reduce Ab toxicity. We used …

Language, Meaning, Context, And Functional Communication, Elizabeth Armstrong, Alison Ferguson

Research outputs pre 2011

No abstract provided.

The Relationship Between A Teacher Check List And Standardised Tests For Visual Perception Skills: A South African Remedial Primary School Perspective, Janet Richmond, K Holland

Research outputs pre 2011

Occupational therapy in remedial education settings has been questioned by the South African Government as they see occupational therapy as a costly service and thus has challenged occupational therapy clinicians’ approach to assessment. This study was undertaken to establish whether the results of standardised tests of visual perception skills, relate to teachers’ observations in respect of primary remedial school age children (six to eleven years) attending a short term remedial school because of low scholastic achievement despite having average or above intellectual ability. The Test of Visual Perceptual Skills – Revised, the Developmental Test of Visual Perception-2, the Jordan Left-Right …

The Mds Mortality Risk Index: The Evolution Of A Method For Predicting 6-Month Mortality In Nursing Home Residents, Davina Porock, Debra Parker-Oliver, Gregory F. Petroski, Marilyn Rantz

Research outputs pre 2011

Accurate prognosis is vital to the initiation of advance care planning particularly in a vulnerable, at risk population such as care home residents. The aim of this paper is to report on the revision and simplification of the MDS Mortality Rating Index (MMRI) for use in clinical practice to predict the probability of death in six months for care home residents.

Skill Acquisition In Skin Cancer Detection, Craig Speelman, Katie Martin, Steven Flower, Terry Simpson

Research outputs pre 2011

Previous research has shown that the ability to detect potentially dangerous skin lesions is not improved by viewing a pamphlet describing the characteristic features of such lesions. A different approach to improving this skill was investigated in this study. 100 student recruits were tested to investigate the effect of practice at distinguishing between dangerous and nondangerous skin lesions. Around 30 minutes of such practice, viewing 360 pictures of skin lesions, provided a significant advantage in making decisions about a target set of dangerous and nondangerous lesions, compared to no practice or practice with a filler task. Viewing a skin cancer …

Pax3 Expression In Normal Skin Melanocytes And Melanocytic Lesions (Naevi And Melanomas), Sandra Medic, Mel Ziman

Research outputs pre 2011

Background Cutaneous Malignant Melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 regulates melanocyte specification from neural crest cells during development but expression in differentiated melanocytes is uncertain. By contrast it is frequently found in melanomas and naevi and is a marker for melanoma staging and detection. In this study we analysed the expression of PAX3 across the spectrum of melanocytic cells, from normal melanocytes to cells of benign and malignant lesions to better assess its function in these various tissues. Pax3 and PAX3 (italicized) refer to the mouse and human gene, respectively; …

The Impact Of Nurses On Patient Morbidity And Mortality: The Need For A Policy Change In Response To The Nursing Shortage, Diane Twigg, Christine Duffield, Peter L. Thompson, Pat Rapley

Research outputs pre 2011

Context. Workforce projections indicate that by 2012 there will be a shortfall of 61 000 registered nurses in Australia. There is a growing body of evidence that links registered nurse staffing to better patient outcomes. Purpose. This article provides a comprehensive review of the research linking nurse staffing to patient outcomes at a time of growing shortages, highlighting that a policy response based on substituting registered nurses with lower skilled workers may have adverse effects on patient outcomes. Method. An electronic search of articles published in English using the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Journals @ …

The Use Of Narrative Fiction To Spread Hiv Information In Papua New Guinea, Trevor Cullen, Ruth Callaghan

Research outputs pre 2011

The nature of media coverage of HIV (Human Immunodeficiency Virus) needs to vary in order to be sustained by newspapers—writing the same message, however worthy, loses impact over time. So an interesting innovation in the 2010 cover­age of HIV in Papua New Guinea (PNG) is the publication of a serialised fiction story in the Post-Courier . It is the story of Vavine, a young girl infected with HIV , who is forced to leave her village after her parents' deaths from AIDS . She keeps her infection secret but because of her circumstances, she is forced to work in a …

The Impact Of The Nursing Hours Per Patient Day (Nhppd) Staffing Method On Patient Outcomes: A Retrospective Analysis Of Patient And Staffing Data, Diane Twigg, Christine Duffield, Alex Bremner, Pat Rapley, Judith Finn

Research outputs pre 2011

In March 2002 the Australian Industrial Relations Commission ordered the introduction of a new staffing method – nursing hours per patient day (NHPPD) – for implementation in Western Australia public hospitals. This method used a ‘‘bottom up’’ approach to classify each hospital ward into one of seven categories using characteristics such as patient complexity, intervention levels, the presence of high dependency beds, the emergency/elective patient mix and patient turnover. Once classified, NHPPD were allocated for each ward. The objective of this study was to determine the impact of implementing the NHPPD staffing method on 14 nursing-sensitive outcomes: central nervous system …

The Impact Of Consanguinity On Neonatal And Infant Health, Alan H. Bittles, Michael L. Black

Research outputs pre 2011

Marriage between biological relatives is widely popular in many parts of the world, with over 1000 million people living in countries where 20–50+% of unions are contracted between couples related as second cousins or closer. Consanguinity is, however, a controversial topic, in part due to public misunderstanding, complicated by often exaggerated past estimates of the adverse health outcomes. While some consanguineous couples are at high risk of conceiving a child with a genetic disorder, they are a small minority. Thus a multi-population meta-analysis has indicated an excess infant death rate of 1.1% in the progeny of first cousins, and even …

Differences In Satiety Effects Of Alginate- And Whey Protein-Based Foods, Vicky A. Solah, Deborah A. Kerr, Cynthia D. Adikara, Xingqiong Meng, Colin W. Binns, Kun Zhu, Amanda Devine, Richard L. Prince

Research outputs pre 2011

Satiety is important in regulating food intake and has important public health significance in the control of obesity. Food containing protein and non-starch polysaccharides provides a satiety effect through various mechanisms but a comparison of the satiety effect on each has not previously been investigated. This study compared the satiety effect or reduction of hunger after consumption of (i) a whey proteinbased drink versus an alginate-based drink of the same viscosity where only the protein content differed, (ii) two alginate-based drinks differing in alginate type and viscosity, and (iii) a whey protein-based drink versus an alginate-based drink differing in protein …

Lactate Dyscrasia: A Novel Explanation For Amyotrophic Lateral Sclerosis, Sivan Vadakkadath Meethal, Craig Atwood

Research outputs pre 2011

Amyotrophic lateral sclerosis (ALS; Lou Gehrig’s disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NMJ) to regulate the flow of lactate from muscle to neurons and vice versa. Failure of the MNLS due to respiratory chain dysfunction is proposed to result in lactate toxicity and degeneration of nerve endings at the NMJ leading to nerve terminus dysjunction from the muscle cell. At a critical threshold where denervation outpaces reinnervation, a vicious cycle …

Adult Outcomes Of Pediatric Traumatic Brain Injury, Miriam Beauchamp, Julian Dooley, Vicki Anderson

Research outputs pre 2011

Traumatic brain injury (TBI) is one of the most common causes of acquired disability during childhood. While the majority of such injuries are mild, and result in few, if any, functional sequelae, children sustaining more significant insults may experience permanent cognitive and behavioral deficits. Clinical reports indicate residual impairments in a range of skills, particularly information-processing, attention, memory, learning, social function and behavior. These deficits impact on a child's capacity to interact with the environment effectively, resulting in lags in skill acquisition, and increasing gaps between injured children and their age peers, as they move through childhood and into adulthood. …

The Development And Implementation Of A Curriculum Using Simulation To Teach Interns Basic Invasive Clinical Skills, C. Sultana, K. Berg, J. Kairys, J. Majdan, M. Vergare, D. Berg

Department of Obstetrics and Gynecology Faculty Papers

The ACGME requires that all residents are competent in performing basic invasive clinical procedures. Although simulation models have been used in other programs to teach these skills to interns with the intent to provide training and skills attainment before learning and performing on real patients, a large scale, mandatory simulation training, in which every incoming intern must satisfactorily complete training in a simulation center, prior to starting their intern year, has yet to be described. We describe such a curricular intervention produced in our Simulation Center.

A Novel Curriculum Using Simulation To Teach And Assess Indications And Technique Of Handwashing To Gme Learners, K. Berg, C. Sultana, R. Sorokin, J. Kairys, M. Vergare, D. Berg

Department of Obstetrics and Gynecology Faculty Papers

Proficiency in the clinical skill of effective hand washing is integral to high quality health care. Studies at our hospital revealed that in 2008, of 1215 direct, anonymous, observations of residents and attendings, only 53.3% washed their hands correctly during clinical activities. Medical students in fiscal year 2009 (July 1, 2008-June 30 2009) had a 52% compliance rate from 109 observations. This data prompted our hospital to work with the faculty of the University Clinical Skills and Simulation Center (UCSSC) to develop a module on the indications and technique of effective handwashing. This intervention, using multimedia simulation was introduced to …