Medicine and Health Sciences Commons^™

Vowel Recognition From Continuous Articulatory Movements For Speaker-Dependent Applications, Jun Wang, Jordan R. Green, Ashok Samal, Tom D. Carrell

Department of Special Education and Communication Disorders: Faculty Publications

A novel approach was developed to recognize vowels from continuous tongue and lip movements. Vowels were classified based on movement patterns (rather than on derived articulatory features, e.g., lip opening) using a machine learning approach. Recognition accuracy on a single-speaker dataset was 94.02% with a very short latency. Recognition accuracy was better for high vowels than for low vowels. This finding parallels previous empirical findings on tongue movements during vowels. The recognition algorithm was then used to drive an articulation-to-acoustics synthesizer. The synthesizer recognizes vowels from continuous input stream of tongue and lip movements and plays the corresponding sound samples …

Conformity To The Surviving Sepsis Campaign International Guidelines Among Physicians In A General Intensive Care Unit In Nairobi, Vitalis Mung’Ayi, R. Karuga

Anaesthesiology, East Africa

Background: There are emerging therapies for managing septic critically-ill patients. There is little data from the developing world on their usage.

Objectives: To determine the conformity rate for resuscitation and management bundles for septic patients amongst physicians in a general intensive care unit.

Design: Cross sectional observational study.

Setting: The general intensive care unit, Aga Khan University Hospital, Nairobi.

Subjects: Admitting physicians from all specialties in the general intensive care unit.

Results: The physicians had high conformity rates of 92% and 96% for the fluid resuscitation and use of va so pressors respectively for the initial resuscitation bundle. They had …

Iptakalim: A Potential Antipsychotic Drug With Novel Mechanisms?, Tao Sun, Changjiu Zhao, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Iptakalim is a novel putative adenosine triphosphate (ATP)-sensitive potassium (K_ATP) channel opener. In the brain, iptakalim is thought to act on the neuronal and astrocytic plasma membrane and/or mitochondrial K_ATP channels. Because iptakalim demonstrates an action on the regulation of dopamine and glutamate release in the forebrain regions, we examined its potential antipsychotic efficacy in several preclinical tests. First, we show that iptakalim is effective in reducing amphetamine- and phencyclidine-induced hyperlocomotion as well as selectively disrupting conditioned avoidance responding. Next, we show that combined iptakalim and amphetamine treatment produces a reduction on prepulse inhibition of acoustic startle …

Punished, Dead Or Alive: Empirical Perspectives On Awarding Punitive Damages Against Deceased Defendants, Timothy R. Robicheaux, Brian H. Bornstein

Department of Psychology: Faculty Publications

Punitive damages are a tool for punishing defendants who engage in reckless and wanton behaviors that cause injury to others. As with criminal punishment, goals of punitive damages include retribution, specific deterrence, and general deterrence. Unlike criminal punishment, however, some courts allow punitive damages to follow the death of defendants. To explore this issue, we first conducted a legal analysis of appellate court decisions concerning punitive damages against deceased defendants. While the majority of courts suggest that punitive damages against deceased individuals are not appropriate, some argue that favorable policy implications of allowing punitive damages to follow the defendant’s death …

Aging And The Vulnerability Of Speech To Dual Task Demands, Susan Kemper, Ralynn Schmalzried, Lesa Hoffman, Ruth Herman

Department of Psychology: Faculty Publications

Tracking a digital pursuit rotor task was used to measure dual task costs of language production by young and older adults. Tracking performance by both groups was affected by dual task demands: time on target declined and tracking error increased as dual task demands increased from the baseline condition to a moderately demanding dual task condition to a more demanding dual task condition. When dual task demands were moderate, older adults’ speech rate declined but their fluency, grammatical complexity, and content were unaffected. When the dual task was more demanding, older adults’ speech, like young adults’ speech, became highly fragmented, …

Donor Payoffs And Other-Regarding Preferences In Cotton-Top Tamarins (Saguinus Oedipus), Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Helping others at no cost to oneself is a simple way to demonstrate other-regarding preferences. Yet, primates exhibit mixed results for other-regarding preferences: chimpanzees and tamarins do not show these effects, whereas capuchin monkeys and marmosets preferentially give food to others. One factor of relevance to this no-cost food donation is the payoff to the donor. Though donors always receive the same payoffs regardless of their choice, previous work varies in whether they receive either a food reward or no food reward. Here, I tested cotton-top tamarins in a preferential giving task. Subjects could choose from two tools, one of …

The Adaptive Nature Of Impulsivity, Jeffrey R. Stevens, David W. Stephens

Department of Psychology: Faculty Publications

An old joke circulates among animal behavior instructors. One can, the joke goes, divide the topics of animal behavior into four Fs: fighting, fleeing, feeding, and reproduction. This somewhat tired joke carries considerable truth. Animals behaving in nature surely must make decisions about conflicts, predator avoidance, feeding, and mating. Male crickets, for example, are notoriously combative. Studies have shown, however, that they escalate fights in some situations and retreat to fight another day in others (Beaugrand, 1997; Parker, 1974; Parker & Rubenstein, 1981). Squirrels, like many small animals, respond to the presence or absence of protective cover; for example, they …

Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

A Clark’s nutcracker (Nucifraga columbiana) flies to the top of a pine tree and selects one of the many cones. She twists and pecks at the stem until the cone breaks free from the branch and, with one foot, holds the cone in the crotch of a branch. She then repeatedly hammers her long bill in between the scales of the cone. After forcing out one of the seeds, she tips her head back a bit, clicks the seed in her bill a few times, and closes her bill. A few minutes later, the shredded cone drops to …

Rational Decision Making In Primates: The Bounded And The Ecological, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Primates constantly face decisions that influence their survival and reproduction. Continue foraging in this tree or move on to another? Expose oneself to a hidden predator by straying from the group or enjoy the safety of having other potential victims nearby? Defend one’s territory from invaders or abandon it and seek a new home? In all of these cases, primates must trade off the costs and benefits associated with uncertain and delayed decision outcomes. The outcomes of these choices influence survival and reproduction, and natural selection should favor those individuals whose choices lead to the propagation of their genes.

The …

Physical, Psychological, And Sexual Intimate Partner Aggression Among Newlywed Couples: Longitudinal Prediction Of Marital Satisfaction, Jillian Panuzio, David K. Dilillo

Department of Psychology: Faculty Publications

This study examined associations between physical, psychological, and sexual intimate partner aggression (IPA) perpetration during the first year of marriage (T1) and victim marital satisfaction one (T2) and two (T3) years later among a sample of 202 newlywed couples. Prevalence rates of all forms of IPA were consistent with those documented in prior research. Higher levels of all types of IPA generally were associated with lower victim marital satisfaction at all time points, when controlling for initial levels of satisfaction. Couples who reported severe bidirectional psychological IPA demonstrated lower husband and wife marital satisfaction at T2 and lower husband satisfaction …

Development And Initial Psychometric Properties Of The Computer Assisted Maltreatment Inventory (Cami): A Comprehensive Self-Report Measure Of Child Maltreatment History, David K. Dilillo, Sarah A. Hayes-Skelton, Michelle A. Fortier, Andrea R. Perry, Sarah E. Evans, Terri L. Messman Moore, Kate Walsh, Cindy Nash, Angèle Fauchier

Department of Psychology: Faculty Publications

Objectives: The present study reports on the development and initial psychometric properties of the Computer Assisted Maltreatment Inventory (CAMI), a web-based self-report measure of child maltreatment history, including sexual and physical abuse, exposure to interparental violence, psychological abuse, and neglect.

Methods: The CAMI was administered to a geographically diverse sample of college students (N= 1,398). For validation purposes, participants also completed a widely used measure of maltreatment (Childhood Trauma Questionnaire) as well as measures of social desirability. To examine test–retest reliability, a subset of participants (n = 283) completed the CAMI a second time 2–4 weeks after …

Emotion Dysregulation And Risky Sexual Behavior In Revictimization, Terri L. Messman-Moore, Kate L. Walsh, David K. Dilillo

Department of Psychology: Faculty Publications

Objective: The current study examined emotion dysregulation as a mechanism underlying risky sexual behavior and sexual revictimization among adult victims of child sexual abuse (CSA) and child physical abuse (CPA).

Methods: Participants were 752 college women. Victimization history, emotion dysregulation, and risky sexual behavior were assessed with anonymous, self-report surveys utilizing a cross-sectional design.

Results: Approximately 6.3% of participants reported CSA, 25.5% reported CPA, and 17.8% reported rape during adolescence or adulthood. CSA and CPA were associated with increased risk for adolescent/adult rape; 29.8% of CSA victims and 24.3% of CPA victims were revictimized. Path analytic models tested hypothesized relationships …

Research Methodology For Validation Of Nutrition Diagnostic Standardized Language Using Fehring Models, Paula K. Ritter-Gooder, Nancy M. Lewis

Department of Nutrition and Health Sciences: Faculty Publications

Validation of the nutrition standardized language (SL) confirms the language is accurate for use in practice, research, and policy. Nutrition diagnostic terms are identified by concept analysis using literature review and experts to distinguish and differentiate one nutrition problem from a similar or related problem. The Fehring models, used in nursing diagnosis validation research, are adopted to validate the SL nutrition diagnostic terms using experts and weighted inter-rater reliability ratios. In the first phase of validation research, diagnostic terms are validated by experts using the Diagnostic Content Validity Model (DCV). A Nutrition Diagnosis Validation Instrument (NDVI) is developed that contains …

Bone Marrow Examination Findings At Aga Khan University Hospital, Nairobi, Nancy Okinda, Riyat Malkit

Pathology, East Africa

Objective: To establish the bone marrow examination findings and determine the indication for bone marrow examination.

Design: A retrospective audit.

Setting: Aga Khan University Hospital, Nairobi.

Subjects: All bone marrow aspirates done at Aga Khan University for the period comprising February 2003 to February 2006 were retrieved and analysed.

Results: A total of 356 patient’s case histories including bone marrow examination results were analysed. Ages of the patients ranged from 18 months to 91 years. Males were 180 (50.6%) and females were 176 (49.4%). Nutritional anaemia as a group was the most common haematological disorder found on bone marrow …

Who Gets Prompt Access To Artemisinin-Based Combination Therapy? A Prospective Community-Based Study In Children From Rural Kilosa, Tanzania, D.O. Simba, M. Warsame, D. Kakoko, Z. Mrango, G. Tomson, Zul Premji, M. Petzold

Pathology, East Africa

Background: Effective and timely case management remains one of the fundamental pillars for control of malaria. Tanzania introduced artemisinin-combination therapy [ACT] for uncomplicated malaria; however, the policy change is challenged by limited availability of ACTs due to high cost. This study aimed to determine factors influencing prompt access to ACTs among febrile children in rural Kilosa, Tanzania.

Methods and Findings: In a community-based study, 1,235 randomly selected children under five were followed up weekly for six months, in 2008. Using a structured questionnaire, children's caretakers were asked about the child's febrile history in the last seven days, and treatment …

Understanding Caretakers' Dilemma In Deciding Whether Or Not To Adhere With Referral Advice After Pre-Referral Treatment With Rectal Artesunate, D.O. Simba, D.C. Kakoko, M. Warsame, Zul Premji, M.F. Gomes, G. Tomson, E. Johansson

Pathology, East Africa

Background: Malaria kills. A single rectal dose of artesunate before referral can reduce mortality and prevent permanent disability. However, the success of this intervention depends on caretakers' adherence to referral advice for follow-up care. This paper explores the dilemma facing caretakers when they are in the process of deciding whether or not to transit their child to a health facility after pre-referral treatment with rectal artesunate.

Methods: Four focus group discussions were held in each of three purposively selected villages in Mtwara rural district of Tanzania. Data were analysed manually using latent qualitative content analysis.

Results: The theme «Caretakers dilemma …

Population Genetic Analysis Of Large Sequence Polymorphisms In Plasmodium Falciparum Blood-Stage Antigens, A.D. Ahouidi, A.K. Bei, D.E. Neafsey, O. Sarr, S. Volkman, D. Milner, J. Cox-Singh, M.U. Ferreira, O. Ndir, Zul Premji, S. Mboup, M.T. Duraisingh

Pathology, East Africa

Plasmodium falciparum, the causative agent of human malaria, invades host erythrocytes using several proteins on the surface of the invasive merozoite, which have been proposed as potential vaccine candidates. Members of the multi-gene PfRh family are surface antigens that have been shown to play a central role in directing merozoites to alternative erythrocyte receptors for invasion. Recently, we identified a large structural polymorphism, a 0.58 Kb deletion, in the C-terminal region of the PfRh2b gene, present at a high frequency in parasite populations from Senegal. We hypothesize that this region is a target of humoral immunity. Here, by analyzing 371 …

Individual, Behavioural And Environmental Pathways To Adolescent Obesity, Paola Teresa Chivers

Theses

The longitudinal investigations of the contributions of obesogenic variables to developmental pathways of adolescent obesity were examined. Key obesogenic variables were examined from the extensive database of the Western Australian Pregnancy Cohort (Raine) Study. The data set included variables collected in utero (18-20 weeks), at birth, and at ages 1, 2, 3, 6, 8, 10, and 14 years.

The key research question was: How do individual, behavioural and environmental factors in childhood contribute to weight status at early adolescence? Investigation of this key question examined how factors change over time and their respective influence on obesity, identified critical points in …

Perspectives Of Executive Women: Life Choices And Balancing Career With Marriage And Children, Wendy James

Walden Dissertations and Doctoral Studies

This qualitative study investigated the experiences of executive women and their choices in balancing work with marriage and children. Research on women in the workplace tends to conflate categories of hourly workers, part-time employees, and middle- and upper-management careers. Yet, the literature on balancing career and family life does not adequately portray the experiences of executive women. The purpose of the study was to discover executive women's perceptions about their career, how they chose their path, and how their career choices affected their decisions about marriage and children. The research questions for this study examined: (a) The effect of executive …

A Phenomenological Inquiry Of Chronic Homeless Individuals' Challenges To Independence, Dewana Hall

Walden Dissertations and Doctoral Studies

Homelessness is a comprehensive social problem affecting approximately 744,000 people in the U.S. Despite consistent efforts from politicians, state and local leaders, and service providers, the number of homeless people continues to rise. Although there are some explanations in the literature to account for the increase of homelessness, the literature tends to not include the voices of the homeless themselves. The purpose of this phenomenological study, which used Maslow's hierarchy of needs as its conceptual framework, was to understand the life experiences of members of the homeless population, as perceived by four male residents of a mission in an eastern …

Illness Uncertainty, Ways Of Coping, And Psychological Adjustment Among 18--25-Year-Olds With Anaphylactic Food Allergy, Susan J. Cohen

Walden Dissertations and Doctoral Studies

The prevalence of food allergy is increasing, with adolescents and young adults being the group most likely to die from food-induced anaphylaxis. Behavioral and psychological factors contribute to this risk. This study investigated the relationship between illness uncertainty (as measured by the Mishel Uncertainty in Illness Scale Community Form) and emotion- and problem-focused coping (as measured by the Ways of Coping Scale), to see if they contributed to psychological adjustment (as measured by the Depression Anxiety Stress Scale-21) in this population. A cognitive diathesis-stress model was used to explain individual differences in adjustment. Multiple regression was used to test illness …

Prolonged Injustice In Urban America, Jametta Magwood, Edith M. Williams, Saundra H. Glover

Faculty Publications

Environmental inequality is the suggestion that the working class, the poor, persons of color, and ultimately the economically disadvantaged are subjected to living conditions that may prove to be hazardous both personally, professionally, and also to the infrastructure of the urban communities that these people inhabit. These injustices affect not only housing but education, quality healthcare access, and access to employment. This article investigates the distinct relationship of environmental inequalities imposed in urban communities that are promoted by a prominent institution: the government. It has been suggested that the government is primarily controlled by individuals who are incapable of identifying …

Evaluation Of Testing And Implementation Of Evidence-Based Rn Bedside Swallow Screen For Dysphagia: A Clinical Practice Change, Edith Matesic

DNP Projects

Stroke patients initially experience dysphagia approximately 42 - 67% of the time with noted improvement reducing rates to approximately 43% at seven days post-acute event (Perry & Love, 2001). The dysphagia experienced by these patients makes them at high risk to develop aspiration pneumonia. Overall, the financial impact of reducing aspiration pneumonia reduces the national cost of morbidity, mortality, and disability burden in this population. There is no generally recognized swallow screen. Program evaluation objectives were to establish a valid, reliable, cost effective, and easy to administer evidence RN bedside swallow screen for dysphagia to keep acute stroke patients safe …

Lessons From A Life Well-Lived, Harold W. Kohl Iii, Steven N. Blair

Faculty Publications

No abstract provided.

Specialty Care Use In Us Patients With Chronic Diseases, Jessica D. Bellinger, Rahnuma M. Hassan, Patrick A. Rivers, Qiang Cheng, Edith M. Williams, Saundra H. Glover

Faculty Publications

Despite efforts to eliminate health disparities, racial, ethnic, and geographic groups continue lag behind their counterparts in health outcomes in the United States. The purpose of this study is to determine variation in specialty care utilization by chronic disease status. Data were extracted from the Commonwealth Fund 2006 Health Care Quality Survey (n = 2475). A stratified minority sample design was employed to ensure a representative sample. Logistic regression was used in analyses to predict specialty care utilization in the sample. Poor perceived health, minority status, and lack of insurance was associated with reduced specialty care use and chronic disease …

Cesarean And Vbac Rates Among Immigrant Vs. Native-Born Women: A Retrospective Observational Study From Taiwan Cesarean Delivery And Vbac Among Immigrant Women In Taiwan, Jung-Chung Fu, Sudha Xirasagar, Jihong Liu, Janice C. Probst

Faculty Publications

Background:Cultural and ethnic roots impact women’s fertility and delivery preferences This study investigated whether the likelihood of cesarean delivery, primary cesarean, and vaginal delivery after cesarean (VBAC) varies by maternal national origin.

Mehods: We conducted a nation-wide, population-based, observational study using secondary data from Taiwan. De-identified data were obtained on all 392,246 singleton live births (≥500 g; ≥20 weeks) born to native-born Taiwanese, Vietnamese and mainland Chinese-born mothers between January 1 2006 and December 31 2007 from Taiwan’s nation-wide birth certificate data. Our analytic samples consisted of the following: for overall cesarean likelihood 392,246 births, primary cesarean 336,766 (excluding …

Recent Advances On Skin-Resident Stem/Progenitor Cell Functions In Skin Regeneration, Aging And Cancers And Novel Anti-Aging And Cancer Therapies., Murielle Mimeault, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Recent advances in skin-resident adult stem/progenitor cell research have revealed that these immature and regenerative cells with a high longevity provide critical functions in maintaining skin homeostasis and repair after severe injuries along the lifespan of individuals. The establishment of the functional properties of distinct adult stem/progenitor cells found in skin epidermis and hair follicles and extrinsic signals from their niches, which are deregulated during their aging and malignant transformation, has significantly improved our understanding on the etiopathogenesis of diverse human skin disorders and cancers. Particularly, enhanced ultraviolet radiation exposure, inflammation and oxidative stress and telomere attrition during chronological aging …

The Effect Of Acupressure On Constipation, Quality Of Life, And Depressive Symptoms In Cancer Patients With Constipation, Eun Jin Lee

University of Kentucky Doctoral Dissertations

Constipation is the most common gastrointestinal complaint in the United States, resulting in about 2 million annual visits to the doctor.

The purposes of this dissertation were to: 1) describe four theories of traditional Korean medicine; 2) review mechanisms of acupuncture and moxibustion and develop a conceptual model; 3) review findings from randomized controlled trials that tested the effects of acupressure used for the management of symptoms such nausea, pain, and dyspnea; 4) examine the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) in heart failure patients with constipation compared to those with gastrointestinal disease; 5) describe how Korean …

Alpha7 Nicotinic Acetylcholine Receptor Regulation In Experimental Neurodegenerative Disease, Christina Margaret Charriez

University of Kentucky Doctoral Dissertations

The α7 nicotinic acetylcholine receptor (nAChR) is involved in learning and memory, synaptic plasticity, neuroprotection, inflammation, and presynaptic regulation of neurotransmitter release. Alzheimer’s disease (AD), a neurodegenerative disease characterized by diminished cognitive abilities, memory loss, and neuropsychiatric disturbances, is associated with a loss of nAChRs. Similarly, traumatic brain injury (TBI) may result in long term neurobehavioral changes exemplified by cognitive dysfunction. Deficits in α7 nAChR expression have previously been shown in experimental TBI and may be related to cognitive impairment experienced in patients following TBI.

The purpose of this dissertation was to investigate changes in α7 nAChR expression in models …

The Outcome Star: A Tool For Recovery Orientated Services; And, Exploring The Use Of The Outcome Star In A Recovery Orientated Mental Health Service, Emma-Louise Keen

Theses : Honours

Objective: The primary objective of this review was to examine the Outcome Star and its utility as a tool for use in recovery oriented mental health services. The secondary objective was to examine similar instruments and their use within mental health services. Methods: Electronic databases Psycinfo, CINAHL, Medline and Proquest were searched. Manual searches of reference lists of retrieved articles and specific journals were undertaken to identify research relevant to describing the structure and properties of the Outcome Star, and its use in mental health settings. Results: A review of the literature revealed that there is a paucity of research …