Medicine and Health Sciences Commons^™

Current Perceptions Regarding The Importance And Safety Of Fish Consumption And Omega-3 Fatty Acid Supplementation Among Pregnant Women, Jessica L. Ess

Master's Theses and Doctoral Dissertations

Background: Previous studies suggest many pregnant women are under-consuming fatty fish and are deficient in omega-3 (ω-3) fatty acids.

Background: Previous studies suggest many pregnant women are under-consuming fatty fish and are deficient in omega-3 (ω-3) fatty acids.

Methods: A 10-question survey distributed to expectant mothers via an online survey and via paper form through 3 obstetric clinics over a 2-month period.

Results: Of the 104 participants, 82% consumed less than 2-3 servings of fish per week, and at least 30% were confused about mercury content. Over 60% of doctors did not provide recommendations regarding ω-3 intake. One-third of participants …

Effects Of Duration Of Selected Music As An Intervention On Postoperative Pain In Open-Heart Surgery Patients During Chair Rest On The First Postoperative Day, Tzu-Ting Shu

Master's Theses and Doctoral Dissertations

The purpose of this study was to test the effects of selected music on reducing postoperative pain and use of pain relief medications in open-heart surgery patients during chair rest on the first postoperative day.

This study was conducted using a pretest-posttest experimental design. A convenience sample of 13 open-heart surgery patients from a metropolitan hospital in southeastern Michigan were randomly assigned to the music group (n = 6) and the control group (n = 7). T-test analysis showed that pain scores (numeric rating scale, NRS = 0-10) were lower in the music group than the control group after 30, …

Influence Of Clinical Research Investigator Fraud On Clinical Trial Participation, Purnachandra Garimella

Master's Theses and Doctoral Dissertations

The number of clinical research investigators whom the Food and Drug Administration (FDA) has disqualified or totally restricted has been increasing since 1964. In addition, several public polls and surveys indicate a major dilemma in clinical trial participation and public perceptions of clinical research. This research investigates how clinical investigator fraud or misconduct influences public perceptions of participation in clinical trials. To meet this challenge, a welldesigned electronic survey was developed for the faculty at Eastern Michigan University (EMU). The survey results indicate that 79% of respondents were ―very likely‖ to be influenced by fraud committed by their own physicians. …

Role Of Extended Release Quetiapine In The Management Of Bipolar Disorders, Martha Sajatovic

Faculty Scholarship

Atypical antipsychotics have become a widely utilized component of the bipolar disorder treatment armamentarium, with approximately 45% of bipolar patients prescribed atypicals. Over the last decade all atypical drugs except for clozapine have received a Food and Drug Administration (FDA) bipolar indication. In October 2008, the FDA approved quetiapine XR monotherapy for the treatment of acute depressive episodes of bipolar disorder and acute manic or mixed episodes in bipolar I disorder based on two placebo-control trials. Quetiapine was also approved as adjunct therapy with lithium and divalproex for the treatment of acute manic or mixed episodes as well as maintenance …

Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets With Alopecia Resulting From A Novel Missense Mutation In The Dna-Binding Domain Of The Vitamin D Receptor., Peter J. Malloy, Jining Wang, Tarak Srivastava, David Feldman

Manuscripts, Articles, Book Chapters and Other Papers

The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol). In this study, we examined the VDR from a young boy with clinical features of HVDRR including severe rickets, hypocalcemia, hypophosphatemia and partial alopecia. The pattern of alopecia was very unusual with areas of total baldness, adjacent to normal hair and regions of scant hair. The child failed to improve on oral calcium and vitamin D therapy but his abnormal chemistries and his bone X-rays normalized …

Psychological Predictors Of Athletic Injury, Sarah Marie Ulrich

Dissertations and Theses @ UNI

To date, research has yet to explore differences in injury based on Fear of Failure (FOF). Therefore, the purpose of this study was to determine if: (a) athletes of varying fear of failure profiles have different perceptions of stress, (b) athletes of varying types of fear of failure differ in regards to injury onset, frequency and severity, and ( c) fear of failure predicts injury occurrence and severity. A total of 127 male collegiate athletes competing in football, wrestling, basketball, and track and field participated in this study. Participants completed the Performance Failure Appraisal Inventory (PF AI) to assess fear …

Substance Use And Injury With College Athletes: Does Injury Affect Perceptions?, Kristine Johnson

Dissertations and Theses @ UNI

Collegiate athletes may perceive the characteristics of substances differently following an injury. Therefore, the purpose of this research was to determine whether perceptions of substance use among collegiate athletes change after an injury occurs. The study also examined differences between sex, scholarship status, and academic level on perceptions of substance use. A total of 141 Division I college athletes participated in this study, with 96 completing the post-test. They were asked to complete a Perceptions of Substance Use Survey in the fall and again in the spring; participants' injury data was collected over a 6 month period from athletic trainers. …

Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway

Browse all Theses and Dissertations

Maternal separation in guinea pigs produces a biphasic response consisting of an active behavior phase followed by a phase of passive behavior (crouched stance, piloerection, and eye closure). Previous studies suggest that pro-inflammatory cytokines mediate passive behavior during the passive phase. It is also known that guinea pig pups separated on two consecutive days show a significant increase (sensitization) in full passive behavior on the second day. The current study examined the persistence and role of pro-inflammatory activity in the sensitization of passive behavior in maternally separated guinea pigs. Guinea pig pups were assigned to one of four groups differing …

Effects Of The Novel Endocannabinoid Uptake Inhibitor, Ly2183240, On Fear-Potentiated Startle And Alcohol-Seeking Behaviors In Mice Selectively Bred For High Alcohol Preference, Matthew S. Powers, G. D. Barrenha, N. S. Mlinac, Eric L. Barker, Julia Chester

Department of Psychological Sciences Faculty Publications

Rationale Alcohol-use disorders often occur together with anxiety disorders in humans which may be partly due to common inherited genetic factors. Evidence suggests that the endocannabinoid system (ECS) is a promising therapeutic target for the treatment of individuals with anxiety and/or alcohol-use disorders. Objectives The present study assessed the effects of a novel endocannabinoid uptake inhibitor, LY2183240, on anxiety- and alcohol-seeking behaviors in a unique animal model that may represent increased genetic risk to develop co-morbid anxiety and alcohol-use disorders in humans. Mice selectively bred for high alcohol preference (HAP) show greater fear-potentiated startle (FPS) than mice selectively bred for …

Pentylenetetrazol Produces A State-Dependent Conditioned Place Aversion To Alcohol Withdrawal In Mice, Julia Chester, Laran E. Coon

Department of Psychological Sciences Faculty Publications

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABAA receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific line selectively bred for low alcohol preference (LAP1; n=91) and were assigned to three groups: alcohol withdrawal, PTZ alone, and PTZ + alcohol withdrawal. On four trials, mice received either a 4.0 g/kg intraperitoneal (i.p.) injection of alcohol (alcohol withdrawal, PTZ + alcohol withdrawal …

Differences In Hospital Glycemic Control And Insulin Requirements In Patients Recovering From Critical Illness And Those Without Prior Critical Illness, April D. Miller, Leslie M. Phillips, Richard M. Schulz, P Brandon Bookstaver, Celeste N. Rudisill

Faculty Publications

INTRODUCTION: Hospital patients recovering from critical illness on general floors often receive insulin therapy based on protocols designed for patients admitted directly to general floors. The objective of this study is to compare glycemic control and insulin dosing in patients recovering from critical illness and those without prior critical illness. METHODS: Medical record review of blood glucose measurements and insulin dosing in 25 patients under general ward care while transitioning from the intensive care unit (transition group) and 25 patients admitted directly to the floor (direct floor group). RESULTS: Average blood glucose did not differ significantly between groups (transition group …

Barbers Against Prostate Cancer: A Feasibility Study For Prostate Cancer Education In An Urban African American Community, John S. Luque, Brian M. Rivers, Maisha Kambon, Ronald Brookins, B. Lee Green, Cathy D. Meade

Community Health: Faculty Publications

The goal of this pilot study was to assess the feasibility of training barbers to deliver a brief culturally and literacy appropriate prostate cancer educational intervention to urban African American men. Eight barbers received training to deliver a 2-month educational intervention in the barbershop and completed pre- and posttest training assessments. The training workshops led to a significant increase in mean prostate cancer knowledge scores among the barbers (60% before vs. 79% after; P < 0.05). The barbers also reported positively on the intervention in terms of satisfaction and relative ease of engaging clients. Training barbers to deliver a prostate cancer educational intervention is a feasible strategy for raising prostate cancer awareness of the disease among a priority population.

Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory, Gregory Miller

Wayne State University Dissertations

The protein deacetylase Sir2 has been shown to increase lifespan in a variety of organisms, possibly through its ability to engender the effects of dietary restriction. The Drosophila nicotinamidase DNAAM increases lifespan in a Sir2 dependant manner, and may play a role in oxidative stress resistance. Oxidative damage that accumulates in cells during normal aging contributes to a variety of diseases and pathologies, and can result in an increase in age specific mortality. Accordingly, the oxidative stress theory of aging predicts that organisms with an increased tolerance to oxidative damage will have an increased longevity, while organisms with decreased tolerance …

The Interictal State In Epilepsy And Behavior, Daniel Tice Barkmeier

Wayne State University Dissertations

Epilepsy is one of the most common neurological diseases, affecting up to 1% of the world population. Epilepsy remains poorly understood and there are currently no medications to cure it. Patients with epilepsy have both seizures as well as another type of abnormal activity between seizures, known as interictal spikes. Interictal spikes have thus far been poorly researched, yet growing evidence supports an important role for them in epilepsy. In this project, we first show the high variability between reviewers in marking interictal spikes on intracranial EEG, and then develop and test an automated detection method to solve this problem. …

Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention, Michael Joseph Frezza

Wayne State University Dissertations

ACTIVATION OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION

by

MICHAEL FREZZA

August 2010

Advisor: Dr. Q. Ping Dou

Major: Cancer Biology

Degree: Doctor of Philosophy

The ubiquitin-proteasome pathway serves as a quality control mechanism to regulate the degradation of intracellular proteins involved in a wide array of cellular processes including tumorigeneis. Thus targeting key features of protein turnover responsible for the growth and proliferation of cancer have emerged as a favorable approach in cancer therapy. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of …

Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans, Gitanjali Kundu

Wayne State University Dissertations

Candida albicans, an opportunistic fungal pathogen, poses a significant clinical threat to immunocompromised patients. Diseases associated with this fungus ranges from superficial mucosal infection to life-threatening systemic candidiasis. The mechanisms by which Candida persists at mucosal surfaces in the face of an adaptive response are unclear. Candida produces immunomodulatory oxylipins that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this fungus during host pathogen interactions, both in vitro with dendritic cells (DCs) and macrophages, and …

A Qualitative Study Of Stressors, Stress Symptoms, And Coping Mechanisms Among College Students Using Nominal Group Process, Helen W. Bland, Bridget F. Melton, Stephen Patrick Gonzalez

Community Health: Faculty Publications

Background: Stress is part of the college experience; however, how students deal with stress can greatly impact their behaviors and health status. Purpose: The purpose of this study was to qualitatively assess sources of stress, types of stressors, and coping mechanisms employed among undergraduate students.

Methods: Nominal group process was utilized to obtain information related to study variables and help prioritize the accounts provided by study participants (n = 173).

Results: Participants gave insight into the unique stress faced by this generation (grades, GPA, multitasking, parental expectations), stress symptoms (more psychological in nature), and coping strategies (prayer, talking to mom, …

Enzymology And Medicinal Chemistry Of N5-Carboxyaminoimidazole Ribonucleotide Synthetase : A Novel Antibacterial Target, Hanumantharao Paritala

Wayne State University Dissertations

N5-Carboxyaminoimidazole ribonucleotide synthetase (N5-CAIR synthetase), a key enzyme in microbial de novo purine biosynthesis, catalyzes the conversion of aminoimidazole ribonucleotide (AIR) to N5-CAIR. To date, this enzyme has been observed only in microorganisms, and thus, it represents an ideal target for antimicrobial drug development. Here we report structural and functional studies on the Aspergillus clavatus N5-CAIR synthetase and identification of inhibitors for the enzyme. In collaboration with Dr. Hazel Holden of the University of Wisconsin, the three-dimensional structure of Aspergillus clavatus N5-CAIR synthetase was solved in the presence of either Mg2ATP or MgADP and AIR. These structures, determined to 2.1 …

Promiscuous Mating In Feral Pigs (Sus Scrofa) From Texas, Usa, Johanna Delgado-Acevedo, Angeline Zamorano, Randy W. Deyoung, Tyler A. Campbell, David G. Hewitt, David B. Long

United States Department of Agriculture Wildlife Services: Staff Publications

Context. Feral pigs represent a significant threat to agriculture and ecosystems and are disease reservoirs for pathogens affecting humans, livestock and other wildlife. Information on the behavioural ecology of feral pigs might increase the efficiency and effectiveness of management strategies.

Aims. We assessed the frequency of promiscuous mating in relation to oestrous synchrony in feral pigs from southern Texas, USA, an agroecosystem with a widespread and well established population of feral pigs. An association between multiple paternity of single litters and synchrony of oestrous may indicate alternative mating strategies, such as mateguarding.

Methods. We collected gravid sows at …

On The Eigenstructures Of Functional K-Potent Matrices And Their Integral Forms, Yan Wu, Daniel F. Linder

Biostatistics: Faculty Publications

In this paper, a functional k-potent matrix satisfies the equation, where k and r are positive integers, and are real numbers. This class of matrices includes idempotent, Nilpotent, and involutary matrices, and more. It turns out that the matrices in this group are best distinguished by their associated eigen-structures. The spectral properties of the matrices are exploited to construct integral k-potent matrices, which have special roles in digital image encryption.

A Study Of The Associations Between Childhood Obesity And Three Forms Of Social Capital, Cynthia Bala-Brusilow

Wayne State University Dissertations

Purpose: The purpose of the study was to expand the understanding of childhood obesity in American children by examining the associations between obesity in children and measures of social capital.

Context: Persons between 2 and 20 years of age are categorized as "obese" if their BMI is in 95th percentile or above for their age and sex using the Center for Disease Control and Prevention (CDC) BMI-for-age growth charts. Obesity prevalence has more than quadrupled in the last 40 years in the United States for children. Social capital, in the study of health, can be defined as resources accrued and/or …

Is Private Long-Term Care Insurance Affordable For Older Adults?, Nayoung Kim

Wayne State University Dissertations

Nationwide there are fewer than 7 million long-term care (LTC) insurance policies in force. Why do so few Americans buy private long-term care (LTC) insurance? Several theories have been offered as possible explanations, including the availability of Medicaid, misperceptions that Medicare or other policies cover LTC, beliefs that one's own risk of needing LTC services is small, or desires to simply rely on children and spouses for LTC. This study examines another possible explanation - that private LTC insurance is simply "unaffordable" for most older Americans, which may be why they don't buy it.

This study begins by investigating the …

Defensins In Ocular Immunity, Minhao Wu

Wayne State University Dissertations

Corneal infection with P. aeruginosa results in corneal perforation in susceptible

B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal

infection, and their potential synergy. Immunostaining and real-time RT-PCR data

demonstrated that their expression was either constitutive (mBD1 and mBD2) or

inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately

regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA

treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in

ocular defense. Moreover, in vivo studies demonstrated individual and combined effects

of mBD2 and …

The Influence Of Religion And Spirituality On Rehabilitation Outcomes Among Traumatic Brain Injury Survivors, Brigid Waldron-Perrine

Wayne State University Dissertations

The long-term consequences of traumatic brain injury affect millions of Americans, many of whom report using religion and spirituality to cope. Little research, however, has investigated how various elements of the religious and spiritual belief systems affect rehabilitation outcomes. The present study sought to assess the use of specifically defined elements of religion and spirituality as coping resources in a sample of traumatically brain injured adults. Furthermore, various mechanisms by which religion and spirituality may affect outcome were explored.

The sample included 88 adults with brain injury from 1 to 20 years post injury and their knowledgeable significant others (SOs). …

Communicative Competence In Persons With Aphasia: The Impact Of Executive Function, Judy Marie Mikola

Wayne State University Dissertations

The purpose of this study was to examine the relationship between executive function and performance on selected linguistic tasks in persons with aphasia secondary to left frontal lesions.

A group of 15 persons with aphasia (PWA) completed three communication board tasks of varying levels of complexity and structure. The subject's functional use of the picture/word communication board was tested during a Story Retelling task. In addition, the PWA's executive function skills were examined using six nonverbal tests. The PWA group performance scores were compared to that of the neurologically healthy control group.

Results demonstrated that the control group performed significantly …

Development And Validation Of A Measurement Scale To Analyze The Environment For Evidence-Based Medicine Learning And Practice By Medical Residents, Fangqiong Mi

Wayne State University Dissertations

A growing number of residency programs are instituting curricula to include the component of evidence-based medicine (EBM) principles and process. However, these curricula may not be able to achieve the optimal learning outcomes, perhaps because various contextual factors are often overlooked when EBM training is being designed, developed, and implemented. The purpose of the study was to develop and validate an instrument, the EBM Environment Scale, to analyze the environment for EBM learning and practice as perceived by medical residents.

The development of the EBM Environment Scale underwent the process of content domain identification, item generation, review by content experts …

Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye

Electronic Theses and Dissertations

Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of nausea and vomiting associated with chemotherapy and for appetite stimulation of AIDS patients suffering from anorexia and wasting syndrome. The only dosage form currently approved by FDA is an oral, soft gelatin capsule (e.g. Marinol®). In addition, orally administered THC from Marinol® has shown slow and variable absorption due to low oral solubility and first pass metabolism. Our …

Determinants Of Bone Mineral Density In African-American And Caucasian College-Aged Women, Andrea K. Johnson

Electronic Theses and Dissertations

Osteoporosis is a serious health issue affecting 10 million Americans, with an additional 44 million being at risk. Due to the morbidity and mortality associated with fractures caused by osteoporosis, it is an important public health concern. Some researchers suggest that African-American women fracture at a lower rate when compared to Caucasians with the same bone mineral density (BMD). However, when African-American women do fracture, they have higher mortality and morbidity rates. Data regarding risk factors and prevalence of low BMD among African American and Caucasian college-aged women are limited. Purpose. The primary purpose of this research was to explain …

Virginia Dental Journal (Vol. 87, No. 1, 2010)

Virginia Dental Journal

No abstract provided.

The Mediating Role Of Psychological Distress In The Relationship Between Adverse Childhood Experiences And Adult Smoking, Tara Wynn Strine

Walden Dissertations and Doctoral Studies

While research has indicated that impaired mental health partially mediates the relationship between adverse childhood experiences (ACEs) and alcohol and illicit drug use, little research has examined potential mediators in the relationship between ACEs and smoking, the number one cause of preventable mortality in the United States. Accordingly, this study examined the potential mediating effect of psychological distress on the relationship between ACES and smoking using data from Wave II of the ACE Study, a cross-sectional study completed between June and October of 1997 on a sample of adult health maintenance organization members (N = 7,211). The theoretical underpinnings for …