Medicine and Health Sciences Commons^™

Bioethics And Biosecurity Education In China: Rise Of A Scientific Superpower., Barr S. Michael, Joy Yueyue Zhang

Book Chapters

This chapter explores ethics, education and the life sciences in China. It is based on work conducted by the authors in two separate but complimentary projects. Barr’s observations derive from interviews and discussions in Beijing, Shanghai and Guangzhou with life scientists and policymakers in infectious-disease hospitals, university-research labs, the Chinese Academy of Sciences, and the Ministry of Health. Zhang’s study focused on China’s governance of stem-cell research and involved interviews with scientists, ethicists and policymakers at more than 25 sites across China. Below, we set the context by describing the role of science in China’s quest to become a leading …

Can There Be A Progressive Bioethics?, Richard O. Lempert

Book Chapters

Progressive bioethics-the words are not an oxymoron. Far from it; they are more redundant than oppositional. Yet they leave me almost as uneasy, as if they were contradictory. My unease exists because bioethics should be neither progressive nor regressive, neither right wing nor left wing, neither liberal nor conservative. It should be just good, sound ethics applied to the often difficult moral problems posed by present-day medicine and the genomic revolution.

I do not mean to suggest by this that all bioethicists need agree. Respectable ethicists using established modes of ethical analysis have long disagreed on and argued for different …

Early Detection Of Response To Hydroxyurea Therapy In Patients With Sickle Cell Anemia., Samir K. Ballas, William F. Mccarthy, Nan Guo, Carlo Brugnara, Gail Kling, Robert L. Bauserman, Myron A. Waclawiw

Department of Medicine Faculty Papers

Red blood cells (RBC) and reticulocyte parameters were determined on peripheral blood from a subset of patients enrolled in the multicenter study of hydroxyuea (HU) in sickle cell anemia. Multiple blood samples were obtained every 2 weeks. Cellular indices were measured by flow cytometry. Generalized linear models were used to determine the relationship between the longitudinal trajectories of RBC and reticulocyte indices and HU usage. There was a significant relationship between HU usage and most of the RBC and reticulocyte indices. Hydroxyurea produced higher value trajectories than those generated by placebo usage for the hemoglobin (Hb) content of both the …

Resting Energy Expenditure Changes With Weight Loss: Racial Differences, Xuewen Wang, Tongjian You, Leon Lenchik, Barbara J. Nicklas

Faculty Publications

It is controversial whether weight loss reduces resting energy expenditure (REE) to a different magnitude in black and white women. This study was to determine whether changes in REE with weight loss were different between black and white postmenopausal women, and whether changes in body composition (including regional lean and fat mass) were associated with REE changes within each race. Black (n= 26) and white (n= 65) women (age= 58.2±5.4 years, 25< BMI< 40 kg·m⁻²) completed a 20-week weight loss intervention. Body weight, lean and fat mass (total body, limb and trunk) via dual energy X-ray absorptiometry, and REE via indirect …

Racial Disparities Between The Sex Steroid Milieu And The Metabolic Risk Profile, Arlette C. Perry, Xuewen Wang, Ronald B. Goldberg, Robert Ross, Loreto Jackson

Faculty Publications

Aims and Method. The present study examined the relationship between the metabolic risk profile (MRP) and total testosterone (TT) and free testosterone using the free androgen index (FAI) and sex hormone binding globulin (SHBG) in 36 Caucasian American (CA) and 30 African-American (AA) women volunteering for a weight loss study. Results. After controlling for age, significant relationships were found between TT and diastolic blood pressure (P = .004 and P = .015 in CA and AA women, resp.). Additionally, total cholesterol (P = .003), low density lipoprotein cholesterol (P = .004), apolipoprotein B (P = .006), …

Metabolic Actions Of Insulin In Men And Women, Faidon Magkos, Xuewen Wang, Bettina Mittendorfer

Faculty Publications

Insulin is an important regulator of glucose, lipid and protein metabolism. It suppresses hepatic glucose and triglyceride production, inhibits adipose tissue lipolysis and whole-body and muscle proteolysis and stimulates glucose uptake in muscle. In this review we discuss what is currently known about the control of substrate metabolism by insulin in men and women. The data available so far indicate that women are more sensitive to insulin with regards to glucose metabolism (both in the liver and in muscle) whereas there are no differences between men and women in insulin action on lipolysis. Potential differences exist in the regulation of …

Occupational Therapists' Perspectives On Psychosocial Treatment Of Sexual Dysfunction With Mental Health Patients, Brittany Siefert, Joseph Troudt

Occupational Therapy Capstones

Purpose: The purpose of this study is to investigate the perceptions of mental health occupational therapists about psychosocial treatment of sexual dysfunction with clients in psychiatric facilities.

Methods: Using qualitative methodology, student researchers interviewed six occupational therapists practicing in psychiatric settings as part of an exploratory study into the perceptions of clinicians about treatment of sexual dysfunction with people who have mental health disabilities. Semi-structured interviews utilized open-ended questions. Electronic recording of interviews was conducted and verbatim transcripts were created. Data was analyzed and emergent codes and themes were developed.

Results: Three themes emerged related to: scope of practice, perceived …

Treating Adults With Chronic Pain: Exploring The Contemporary Trends Of Occupational Therapy, Jennifer Gough, Laura Roush

Occupational Therapy Capstones

Purpose: The aim of this study was to explore occupational therapy’s approach in treating individuals with chronic pain. More specifically, to evaluate occupational therapy’s role in current practices including assessments, models of practice, modalities, and competencies.

Methodology: Following IRB approval, a purposive sampling method was used to gain a sufficient number of participants to complete an online survey. Inclusion criteria for participants in this study included occupational therapists currently working in an outpatient setting, current members of the American Occupational Therapy Association (AOTA), and practicing within the states of Wyoming, North Dakota, South Dakota, Montana, Colorado, and Nebraska. Subjects were …

A Holistic Treatment Approach For Individuals Experiencing Phantom Phenomena: An Occupational Therapy Approach, Jenna Akkanen, Laura Olauson

Occupational Therapy Capstones

The prevalence of individuals who have had an amputation and experience adverse types of sensory input from the missing limb is very high (Hunter, Katz, & Davis, 2005). According to the literature, sensory input can be divided into non-painful sensations or painful sensations in the amputated limb often called "phantom sensations." These pains and sensations can have many negative implications upon an individual's occupational performance, and consequently directly implicate the need for occupational therapy. A large number of persons post-amputation experience pain and different sensations from their affected limb even after the healing process has finalized; the etiology behind why …

The Adl Of Sexuality: A Guide For Occupational Therapists For Elderly Clients, Autumn Edmundson, Amber Lafrenz

Occupational Therapy Capstones

Purpose: The purpose of this scholarly project was to develop a guide that would address the assessments, treatment/interventions, and discharge planning process regarding sexual health/sexuality with an elderly client. Through the use of the guide and accompanying resources it is assumed that occupational therapists will have an increased level of comfort, knowledge, and competence. This is important as Couloumbis and Miller (1994) study indicated that occupational therapists that received formal education (academically or clinical practice) addressed sexuality in the elderly 27.8% more than occupational therapists who did not have any educational experience.

Methodology: An in depth literature review was conducted …

Differentiating Dementia From Mental Illness In The Elderly: An Occupational Therapy Process, Michelle Halsted

Occupational Therapy Capstones

The purpose of this product is to provide those persons admitted to a hospital setting with an unclear diagnosis the opportunity to be efficiently and accurately diagnosed, thus allowing proper treatment, medications, and placement, if needed. Often, . there is confusion amongst professionals in the treatment team as to whether an older adult may have a developing dementia versus symptoms of a mental illness. Through the evaluation process, individuals will engage in a balance of evaluative activities that may improve physical, social, emotional, spiritual, occupational, and cognitive focus areas. These evaluations are primarily based on Allen's Cognitive Model and The …

Use Of Myofascial Release And Proprioceptive Neuromuscular Facilitation In Combination With A Rehabilitation Protocol For A Patient Following A Massive Rotator Cuff Tear And Repair: A Case Report, Bryan L. Arroyo

Physical Therapy Scholarly Projects

Background and Purpose. This case report describes the use of postoperative treatments incorporating myofascial release and proprioceptive neuromuscular techniques, on a 59-year-old male who underwent a left open rotator cuff repair following a massive rotator cuff tear. This was after an 8 week passive motion phase. The goals of this case report were to evaluate the feasibility of these techniques and to examine improvements in shoulder range of motion, function of the involved extremity, and pain reduction.

Case Description. The patient suffered a massive rotator cuff tear at work after falling on his shoulder. The patient started with an 8 …

Grade I Slap Lesion: A Conservative Treatment Approach, Joseph Klatt

Physical Therapy Scholarly Projects

Background and Purpose: This case report describes the examination, intervention, and outcome of a patient with a grade I SLAP lesion using non-surgical physical therapy intervention. Detailed conservative strategies have not been previously described in the literature.

Case Description: The patient was a 39 year old male with a grade I SLAP lesion of the left shoulder with a significant history of shoulder pain since he pitched in the minors at age 23. Prior to formal physical therapy intervention the patient had pain rated at 7 out of 10 and could not perform overhead activities and ADLs such …

Physical Therapy Interventions For Multiple Sclerosis And Diplegia, Kyle R. Nyquist

Physical Therapy Scholarly Projects

Background and Purpose – It is estimated that approximately 2.5 million people world-wide suffer from multiple sclerosis (MS). MS is a neurological disease that impacts messages from the brain to motor and sensory nerves. This disruption can cause loss of sensation and motion to a specific region of the body. The purpose of this case study is to identify interventions used for a person with multiple sclerosis.

Case Description – The Patient is a 40-year-old male who has been suffering from MS for 27 years. He has lost the use of his lower extremities and had contractures at his knees …

In Remembrance Of Denis Alan Trevor New, Robert L. Brent Dr.

The Selected Works of Robert Brent

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Ionizing Radiation, Robert L. Brent Dr.

The Selected Works of Robert Brent

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Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being validated as a technique to identify occult lymph node metastases in patients with colorectal cancer and for circulating cells in the blood for postoperative surveillance. Although Guanylyl cyclase C is widely expressed by well-differentiated colorectal cancer, its expression in poorly differentiated colorectal cancer has not been evaluated. A …

A Bimodal Distribution Of Two Distinct Categories Of Intrinsically Disordered Structures With Separate Functions In Fg Nucleoporins, Justin Yamada, Joshua L. Philips, Samir Patel, Gabriel Goldfien, Alison Calestagne-Morelli, Hans Huang, Ryan Reza, Justin Acheson, Viswanathan V. Krishnan, Shawn Newsam, Ajay Gopinathan, Edmond Y. Lau, Michael E. Colvin, Vladimir N. Uversky, Michael F. Rexach

Molecular Medicine Faculty Publications

Nuclear pore complexes (NPCs) gate the only conduits for nucleocytoplasmic transport in eukaryotes. Their gate is formed by nucleoporins containing large intrinsically disordered domains with multiple phenylalanine-glycine repeats (FG domains). In combination, these are hypothesized to form a structurally and chemically homogeneous network of random coils at the NPC center, which sorts macromolecules by size and hydrophobicity. Instead, we found that FG domains are structurally and chemically heterogeneous. They adopt distinct categories of intrinsically disordered structures in non-random distributions. Some adopt globular, collapsed coil configurations and are characterized by a low charge content. Others are highly charged and adopt more …

3, 4-Dihydroxyphenylacetic Acid (Dopac) Impairs Α-Synuclein Interaction With Lipids, Wenbo Zhou, Chunmei Long, Anthony L. Fink, Vladimir N. Uversky

Molecular Medicine Faculty Publications

α-Synuclein (α-Syn) is a small intrinsically disordered presynaptic protein known to form insoluble filamentous inclusions in Parkinson’s disease (PD) and other neurodegenerative disorders. Various catecholamines can inhibit the α-Syn fibrillation in vitro. Recently, non-covalent binding of DOPAC (3,4-dihydroxyphenylacetic acid), a normal product of the dopamine metabolism, was shown to inhibit the fibrillation of α-Syn due to the DOPAC-induced stabilization of the normally transient oligomers thus preventing them from subsequent fibril formation (Zhou, et al. J. Mol. Biol. 2009, 388 (3), 597-610). We are showing here that the interaction of DOPAC with α-Syn decreases the binding affinity of α- Syn to …

Effects Of Various Flavonoids On The Α-Synuclein Fibrillation Process, Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

Molecular Medicine Faculty Publications

α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therapeutic agent directed toward preventing the protein aggregation, which has been recently shown to have a key role in the cytotoxic nature of amyloidogenic proteins. Flavonoids, known as plant pigments, belong to a broad family of polyphenolic compounds. Over 4,000 flavonoids have been identified from various plants and foodstuffs derived from plants and have been demonstrated as potential neuroprotective agents. In this study 48 flavonoids belonging to …

Computational Prediction And Analysis Of The Napp – Dr6 Interaction: Implications For Alzheimer's Research, Joseph Audie, Sergei Y. Ponomarev

Chemistry & Physics Faculty Publications

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that involves a devastating clinical course and lacks an effective treatment. A biochemical model for neuronal development, recently proposed by Nikolaev and co-workers, hinges on a novel protein-protein interaction between the death cell receptor six (DR6) ectodomain and an N-terminal fragment of amyloid precursor protein (NAPP). The model provides a coherent and satisfying framework for better understanding AD pathophysiology. Moreover, the DR6-NAPP interaction offers a tempting target for novel pharmacological intervention. Given all of this, we constructed a structural model of the DR6-NAPP interaction using the neurotrophin p75 receptor as a template. …

Professional Product Review Vol. 5 No. 1, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz

Wayne State University Dissertations

The amygdala processes stimuli that threaten an individual and organizes the execution of affective behaviors designed to cope with the threat. The prototypical threat to an individual is exposure to a noxious stimulus. The central nucleus of the amygdala (CeA) receives nociceptive afferents and exhibits neuronal activation in response to noxious peripheral stimulation. NMDA receptors within CeA mediate this noxious-evoked neural excitation, and previous studies in the laboratory have shown that blockade of CeA NMDA receptors via the antagonist APV elevates the threshold for noxious tail-shock-induced vocalization afterdischarges (VADs), a validated measure of pain affect in the rat. The present …

Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka

Wayne State University Dissertations

Myelin is a multilamellar membrane structure surrounding axons in both the CNS and PNS that facilitates nerve conduction. In the CNS, myelin is synthesized by oligodendrocytes, while in the PNS, myelin is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe Pelizaeus-Merzbacher disease (PMD), that typically begins during infancy with nystagmus, seizures and hypotonia and evolves into spastic quadriparesis, cognitive impairment and ataxia, to ¡¥pure¡¦ …

A Descriptive Analysis Of Bookings In Sibley County Jail Between January 1, 2008 And December 31, 2009, Deanna Aufderheide

All Graduate Theses, Dissertations, and Other Capstone Projects

Each year approximately 12 million admissions and releases occur in U.S. jails (Solomon, A. L., Osborne, J. W. L, LoBuglio, S. F., Mellow, J., & Mukamal, D. A.). Those that cycle in and out of jail often times are unstable. These instabilities include: substance abuse, lack of housing and employment, mental illness, and health concerns. More than 80 percent of offenders are incarcerated for less than one month; some for a few hours or a few days (Solomon, et. al.). This concern was identified by the Public Health Nurse (PHN) who has seen the same offenders being booked in, time …

Innovative Mental Health Services In Rural Minnesota: Community-Based Mobile Crisis Response Services, Rebecca A. Zuehlke

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this research project was to explore the relationship between the frequency of service utilization of the Community-based Mobile Crisis Response Services (MCR) provided by the Southwestern Mental Health Center (SWMHC) and the frequency of service utilization of emergency holds and civil commitments in Jackson and Cottonwood counties by month for the 2009 calendar year.

The specific research question proposed was: Is there a relationship between the frequency of Community-Based Mobile Crisis Response Services and the frequency of emergency holds and civil commitments in Jackson and Cottonwood Counties?

The significance of this research project was to explore statistically …

Independent Living Outcomes Evaluation Project, Craig J. Padgett

All Graduate Theses, Dissertations, and Other Capstone Projects

This project developed specific examples of skills and resources for three example categories of ILST and developed recommendations for enhancing the creation of goals. It was important to develop indicators into a tiered structure for reinforcing those skills and resources into knowledge through an added educational component. Methodology was developed and necessary instrumentation and processes were designed for implementation. And, an informed consent was designed for any organization providing Independent Living Skills Training (ILST).

From A Constitutional Right To A Policy Of Exceptions: Abigail Alliance And The Future Of Access To Experimental Therapy, Patricia J. Zettler, Seema K. Shah

Faculty Publications By Year

Although there has been considerable attention to the plight of terminally ill patients with highly sympathetic constitutional and contractual claims that they should be permitted access to unapproved drugs, courts have been appropriately reluctant to grant such claims. Congress and administrative agencies have the requisite institutional competence to decide complex policy issues related to science and health care such as those involved in establishing an expanded access program. Congress and FDA should allow only limited access to unapproved therapies because there are significant concerns about the safety and efficacy of unapproved drugs. Moreover, many of the proposals to widen access …

Program And Proceedings: Nebraska Academy Of Sciences 1880–2010, 130th Anniversary Year, One Hundred-Twentieth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Chemistry and Physics

Collegiate Academy: Biology

Collegiate Academy: Chemistry and Physics

Biological and Medical Sciences

Chemistry and Physics

History and Philosophy of Science

Nebraska Wesleyan University Health and Sciences Graduate School Fair

Junior Academy, Senior High Competition/p>

Aeronautics and Space Science, Poster Session

Teaching of Science and Math

Maiben Memorial Lecture: Mark Greip, Department of Chemistry, University of Nebraska–Lincoln

Aeronautics

Anthropology

Junior Academy, Senior High Competition

Earth Science

Junior Academy, Junior High Competition

The Effects Of Pet Ownership On Physical Well-Being In Older Adults, Tami Pohnert

Theses and Dissertations

A large percentage of Americans own pets which may impact their health. This study examines pet ownership’s effect on well being in older adults looking at race/ethnicity. A sample of 6,565 older adults (>60) was selected from the Third National Health and Nutrition Survey. Pet owners comprised 28.3% of the sample. The theories of symbolic interaction and social integration were used to examine pet ownership’s effect on physical components of well-being. The descriptive results showed statistically significant differences in age, education, income, and marital status between pet owners and non-pet owners. Pet owners were younger, more educate, higher income …