Medicine and Health Sciences Commons^™

A Molecular Dynamics Investigation Of Lipid Bilayer Perturbation By Pip2, Dmitry Lupyan, Mihaly Mezei, Diomedes E. Logothetis, Roman Osman

Physiology and Biophysics Publications and Presentations

Abstract

Phosphoinositides like phosphatidylinositol 4,5-bisphosphate (PIP₂) are negatively charged lipids that play a pivotal role in membrane trafficking, signal transduction, and protein anchoring. We have designed a force field for the PIP₂ headgroup using quantum mechanical methods and characterized its properties inside a lipid bilayer using molecular dynamics simulations. Macroscopic properties such as area/headgroup, density profiles, and lipid order parameters calculated from these simulations agree well with the experimental values. However, microscopically, the PIP₂ introduces a local perturbation of the lipid bilayer. The average PIP₂ headgroup orientation of 45° relative to the bilayer …

Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome In A Pakistani Pedigree, Tanveer Anjum Chaudhry, Mirza Umair Khalid, Taimur Saleem, Khabir Ahmad

Section of Ophthalmology

Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare developmental ocular disorder. We report this condition affecting 4 members of a Pakistani family across three generations. A 2-year-old girl was brought to the clinic by her father for the correction of her shortened palpebral fissures. Examination findings were consistent with BPES. The girl's father, paternal grandfather and paternal aunt also had identical features. The distance between the medial canthi of the index case was 30 mm, and the lengths of vertical and horizontal palpebral fissure were 6 mm and 20 mm, respectively. BPES must be considered an important differential diagnosis in patients …

Increasing The Use Of Booster Seats: A Community-Based Research Project, Michelle Gallina, Amanda Jones, Jane Kim, Habibullah Muhiddin, Natasha Singletary

OUR Journal: ODU Undergraduate Research Journal

The aim of this project was to increase booster seat usage and knowledge of booster seat safety by implementing population-based interventions in the community. To aid in accomplishing the goal, the nursing students utilized the performance of an educational puppet show, educational handouts, and aggregate height and age screening as the interventions. Pre and post tests data were obtained. As a result, there was an increase of the aggregates‟ desire to be in a booster seat. Nurses who take more action in a leadership role by implementing interventions based on the educational needs of the community increased booster seat awareness. …

Loma Linda University Dentistry - Volume 21, Number 1, Loma Linda University School Of Dentistry

Articulator (Dentistry)

Contents:

8 | Los Angeles Free Clinic
11 | Misuse of Statistics in Dental Research
19 | “On the Heights” with Peter Nelson
22 | 50th Alumni Student Convention
24 | Dr. Roggenkamp’s Centurian Becomes Flying Instructor
29 | LLUSD Society of Scholars
36 | California Governor Appoints LLUSD Faculty and Alumnus

Stigma Reduction Techniques/Campaigns For Practitioners In A Rural Community Mental Health Practice, Becky Mensing

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to systematically review the literature on the negative effects of stigma on the therapy seeking clients of rural mental health centers. Also to provide information on anti-stigma campaign efforts. The goal of anti-stigma programs are to create awareness about how stigma affects people with mental illnesses, and to have participants develop a sense of what it means to walk in the shoes of a person with mental illness (Corrigan, 2004, p. 19). The research question was how do we help people from being victimized by the prejudice and discrimination that arises from stigma?

Introduction: Obstacles To The Development And Use Of Pharmacotherapies For Addiction, Richard C. Boldt

Journal of Health Care Law and Policy

No abstract provided.

The Virtues Of Pragmatism In Drug Policy, Richard J. Bonnie

Journal of Health Care Law and Policy

No abstract provided.

Harm Reduction And The American Difference: Drug Treatment And Problem-Solving Courts In Comparative Perspective, James L. Noland Jr.

Journal of Health Care Law and Policy

No abstract provided.

The Food And Drug Administration And The Pharmacy Profession: Partners To Ensure The Safety And Efficacy Of Pharmacogenomic Therapy, Jennifer E. Spreng

Journal of Health Care Law and Policy

No abstract provided.

Follow-On Biologics: Legal, Scientific, And Policy Considerations, Jeremiah L. Kelly

Journal of Health Care Law and Policy

No abstract provided.

Keeping Prevention In The Crosshairs: A Better Hiv Exposure Law For Maryland, Sara Klemm

Journal of Health Care Law and Policy

No abstract provided.

Evaluation Of Concurrent Medications Pre- And Post Initiation Of Long-Acting Injectable Antipsychotic Therapy, Lindsay Pokallus Pharmd, Laurence Karper Md, Jessica Price Pharmd, Bcps

Department of Pharmacy

No abstract provided.

A Correlational Study Of Telework Frequency, Information Communication Technology, And Job Satisfaction Of Home-Based Teleworkers, Shana P. Webster-Trotman

Walden Dissertations and Doctoral Studies

In 2008, 33.7 million Americans teleworked from home. The Telework Enhancement Act (S. 707) and the Telework Improvements Act (H.R. 1722) of 2009 were designed to increase the number of teleworkers. The research problem addressed was the lack of understanding of factors that influence home-based teleworkers' job satisfaction. Job dissatisfaction has been found to have a significant impact on voluntary turnover. The purpose of the study was to assess the relationship among telework frequency, information communication technology (ICT), and job satisfaction. The research questions were designed to answer whether correlational relationships exist among telework frequency, ICT, and job satisfaction and …

Job Satisfaction, Job Involvement, And Perceived Organizational Support As Predictors Of Organizational Commitment, Jennifer Parker Ayers

Walden Dissertations and Doctoral Studies

The purpose of this study was to determine whether or not there is a significant relationship between job satisfaction, job involvement, perceived organizational support, and organizational commitment among educators. A review of the literature revealed there is limited research that examined organizational behaviors among educators. Organizational commitment has been identified as a leading factor impacting an employee's level of success in various organizations. There remains a gap in the current literature regarding specific attitudinal behaviors influencing organizational commitment across various levels of education. Organizational commitment among educators employed at the primary, secondary, and postsecondary levels was examined. The sample for …

Who Shares? Managerial Knowledge Transfer Practices In British Columbia's Ministry Of Health Services, Gwendolyn Elizabeth Lock

Walden Dissertations and Doctoral Studies

The British Columbia government's Ministry of Health Services will experience significant loss of operational knowledge from an aging managerial workforce, increased staff turnover, and difficulties in recruitment. The purpose of this study is to provide the ministry's Strategic Human Resources Planning branch staff with a map and description of knowledge transfer practices used by approximately 40 managers within the ministry's Health Sector Information Management/Information Technology division and its Vital Statistics Agency. The study is a mixed-methods case study of knowledge retention and transfer practices founded on a knowledge management and social network theoretical foundation. To understand the ministry's complex nature …

Risk Factors For Development Of High Blood Pressure And Obesity Among African American Adolescents, Monique Shanta White

Walden Dissertations and Doctoral Studies

Childhood obesity has reached epidemic proportions in the United States and has been linked to hypertension, especially among African American youth. Optimistic bias leads youth to underestimate their susceptibility to negative health outcomes. Public health officials want to reduce risk factors to result in significant long term reduction in cardiovascular disease. The purpose of this study was to explore adolescent behavior practices in a school district and prevalence of high blood pressure and obesity in that population. The health belief model guided the framework for this study. Research questions examined relationship between individual health risk practices and optimistic bias on …

The Relationship Between Leadership Styles And Performance Success In Hospitals, Beverly J. D. Hernandez

Walden Dissertations and Doctoral Studies

Upheavals in the health care landscape threaten the sustainability of contemporary hospital organizations. Yet there is limited research regarding the characteristics of leaders within successful hospitals. The problem is the leadership styles needed to effectively run hospital organizations have not been identified and/or established. The purpose of this study was to develop a model of congruent leadership styles linked to the success of hospitals in one metropolitan city. The research questions sought to uncover (a) consistent leadership styles within successful hospitals, and (b) what, if any, relationship exists between leadership styles and measures of success. Examination of the literature uncovered …

National Survey On Equine Assisted Therapy: An Exploratory Study Of Current Practitioners And Programs, Patricia J. Mcconnell

Walden Dissertations and Doctoral Studies

Equine facilitated psychotherapy (EFP), a new field in psychology, is an alternative method of therapy that uses horses to facilitate therapeutic outcomes. There is minimal peer reviewed literature and few published studies examining efficacy. The conceptual lens of this study was grounded theory, as there is insufficient evidence of theoretical frame-works guiding equine assisted therapy. The purpose of this exploratory concurrent mixed methods study was to examine the theoretical foundation of practitioners; program make up; client populations; efficacy of program; and why the horse serves as the therapeutic catalyst of this model. A 43-item survey was sent to 800 programs, …

A "Pawsitive" Influence Of Animals In Long-Term Care Facilities: Animal-Assisted Therapy At St. Peter Regional Treatment Center, Hannah L. Winkler

All Graduate Theses, Dissertations, and Other Capstone Projects

The St. Peter Regional Treatment Center (SPRTC) provides secure, residential, multi-disciplinary treatment services, including psychosocial rehabilitation and skill enhancement, to individuals civilly committed as Mental Ill and Dangerous by the State of Minnesota. Since the treatment process is so comprehensive at SPRTC, patients may spend several years receiving in-patient treatment.

Since SPRTC does not currently have an animal-assisted therapy (AAT) program, the purpose of this project was to research existing AAT programs being implemented with similar patient populations as a way to inform SPRTC staff of possible programs they could implement on their campus. The overall goal of this project …

The Pursuit Of Language Appropriate Care: Remote Simultaneous Medical Interpretation Use, Debra M. Logan

Nursing Dissertations - Archive

Background. The U.S. government mandates nurses to deliver linguistically appropriate care to hospital patients. It is difficult for nurses to implement the language mandates because there are 6,912 active living languages spoken in the world. Language barriers appear to place limited English proficient (LEP) patients at increased risk for harm when compared to non-LEP patients. Hospitals, a primary nurse employer, are responsible for supplying language services to support accessible, quality care to linguistically diverse populations. This descriptive study explored relationships among the use of remote simultaneous medical interpretation (RSMI) in hospital settings, hospital size as an indicator of organizational resources …

Variables Predictive Of Outcome In Patients With Acute Hypercapneic Respiratory Failure Treated With Noninvasive Ventilatio, Nawal Salahuddin, Muhammad Irfan, Shereen Khan, Muhammad Naeem, Ahmad Suleman Haque, Shahid Javed Husain, Nisar Ahmed Rao, Ali Bin Sarwar Zubairi, Javaid Khan

Section of Pulmonary & Critical Care

OBJECTIVE: To assess results with NIV in acute hypercapneic respiratory failure and to identify outcome predictors.

METHODS: This was a retrospective observational study on consecutive patients presenting with acute type II respiratory failure and meeting criteria for NIV use over a 5 year period. Patients presenting with haemodynamic instability, inability to protect their airway, malignant arrhythmias and recent oesophageal surgery were excluded. Univariate and Multivariate regression analysis was used to determine the impact on survival. A p value of < 0.05 was considered statistically significant. Software used was SPSS 14.

RESULTS: Total numbers of patients included were 119; 52.9% were males. Mean age was 63.4 +/- 11.9 years. Overall Survival to …

Diverticular And Aneurysmal Structures Of The Left Ventricle In Adults: Report Of A Case Within The Context Of A Literature Review., Premraj Makkuni, Morris N Kotler, Vincent M. Figueredo

Department of Medical Genetics Faculty Papers

Left ventricular outpouchings are increasingly detected on cardiovascular imaging. Herein, we describe the case of a 45-year-old man who underwent noncardiac preoperative imaging and was found to have an asymptomatic left ventricular outpouching. The patient underwent successful surgical repair of the structure. When left ventricular outpouchings are detected, the main differential diagnoses are pseudoaneurysm, aneurysm, and diverticulum. The outcomes for these conditions differ substantially, and accurate diagnosis can be crucial in making clinical decisions. We review the relevant medical literature, outline the natural history of these left ventricular abnormalities, and discuss options in regard to their management.

Letter To The Editor: Reproductive Toxicology, Robert L. Brent

The Selected Works of Robert Brent

No abstract provided.

What Are The Reproductive And Developmental Risks Of Ionizing Radiation?, Robert L. Brent Dr.

The Selected Works of Robert Brent

None

Mechanism Of Catch Force: Tethering Of Thick And Thin Filaments By Twitchin., Thomas M Butler, Marion J Siegman

Department of Molecular Physiology and Biophysics Faculty Papers

Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular calcium is near basal concentration and myosin crossbridge cyctng rate is extremely slow. Catch force is relaxed by a protein kinase A-mediated phosphorylation of sites near the N- and C- temini of the minititin twitchin (approximately 526 kDa). Some catch force maintenance car also occur together with cycling myosin crossbridges at submaximal calcium concentrations, but not when the muscle is maximally activated. Additionally, the link responsible for catch can adjust during shortening of …

Differential Impact Of Tumor Suppressor Pathways On Dna Damage Response And Therapy-Induced Transformation In A Mouse Primary Cell Model., A Kathleen Mcclendon, Jeffry L Dean, Adam Ertel, Erik S Knudsen

Department of Cancer Biology Faculty Papers

The RB and p53 tumor suppressors are mediators of DNA damage response, and compound inactivation of RB and p53 is a common occurrence in human cancers. Surprisingly, their cooperation in DNA damage signaling in relation to tumorigenesis and therapeutic response remains enigmatic. In the context of individuals with heritable retinoblastoma, there is a predilection for secondary tumor development, which has been associated with the use of radiation-therapy to treat the primary tumor. Furthermore, while germline mutations of the p53 gene are critical drivers for cancer predisposition syndromes, it is postulated that extrinsic stresses play a major role in promoting varying …

Junctional Adhesion Molecule-A Is Abnormally Expressed In Diffuse Cutaneous Systemic Sclerosis Skin And Mediates Myeloid Cell Adhesion., Y Hou, B J Rabquer, M L Gerber, F Del Galdo, S A Jimenez, G K Haines, W G Barr, M C Massa, J R Seibold, A E Koch

Scleroderma Center Faculty Papers

OBJECTIVE: To investigate the role of junctional adhesion molecule-A (JAM-A) in the pathogenesis of systemic sclerosis (SSc).

METHODS: Biopsy specimens from proximal and distal arm skin and serum were obtained from patients with SSc and normal volunteers. To determine the expression of JAM-A on SSc dermal fibroblasts and in SSc skin, cell surface ELISAs and immunohistology were performed. An ELISA was designed to determine the amount of soluble JAM-A (sJAM-A) in serum. Myeloid U937 cell-SSc dermal fibroblast and skin adhesion assays were performed to determine the role of JAM-A in myeloid cell adhesion.

RESULTS: The stratum granulosum and dermal endothelial …

Increasing Complexity: Resisting Simplification In Forensic Psychology, Diane R. Follingstad

CRVAW Faculty Journal Articles

The American Academy of Forensic Psychology annually presents a Distinguished Contribution in Forensic Psychology Award to an individual whose work has significantly moved the field forward. Dr. Follingstad received this award for decades of productive research, testimony, and public education regarding family, adolescent, and women's issues, all areas in which she has received numerous research grants over the years. Following is her acceptance speech, presented at the American Psychology-Law Association convention in Vancouver, B.C. in March 2010.

Reduced Hamster Usage And Stress In Propagating Leishmania Chagasi Promastigotes Using Cryopreservation And Saphenous Vein Inoculation, Soi Meng Lei, Amanda E. Ramer-Tait, Rebecca R. Dahlin-Laborde, Kathleen Mullin, Jeffrey K. Beetham

Amanda Ramer-Tait Publications

Leishmania chagasi, a causal agent of visceral leishmaniasis, requires passage through lab animals such as hamsters to maintain its virulence. Hamster infection is typically accomplished via cardiac puncture or intraperitoneal injection, procedures accompanied by risks of increased animal stress and death. The use of the hamster model also necessitates a regular supply of infected animals, because L. chagasi parasites newly isolated from an infected hamster can be grown in culture for only several weeks before loss of function/phenotype occurs. In an effort to decrease animal usage and animal stress, experiments were performed to assess a more gentle inoculation …

Individuality In Gut Microbiota Composition Is A Complex Polygenic Trait Shaped By Multiple Environmental And Host Genetic Factors, Andrew K. Benson, Scott A. Kelly, Ryan Legge, Fangrui Ma, Soo Jen Low, Jaehyoung Kim, Min Zhang, Phaik Lyn Oh, Derrick Nehrenberg, Kunjie Huab, Stephen D. Kachman, Etsuko N. Moriyama, Jens Walter, Daniel A. Peterson, Daniel Pomp

Center for Plant Science Innovation: Faculty Publications

In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. Although external and stochastic factors clearly contribute to the individuality of the microbiota, the fundamental principles dictating how environmental factors and host genetic factors combine to shape this complex ecosystem are largely unknown and require systematic study. Here we examined factors that affect microbiota composition in a large (n = 645) mouse advanced intercross line originating from a cross between C57BL/6J and an ICR-derived outbred line (HR). Quantitative pyrosequencing of the microbiota defined a core measurable microbiota …