Medicine and Health Sciences Commons^™

Supply Sensitive Services In Swiss Ambulatory Care: An Analysis Of Basic Health Insurance Records For 2003-2007, André Busato, Pius Matter, Beat Künzi, David C. Goodman

Dartmouth Scholarship

Swiss ambulatory care is characterized by independent, and primarily practice-based, physicians, receiving fee for service reimbursement. This study analyses supply sensitive services using ambulatory care claims data from mandatory health insurance. A first research question was aimed at the hypothesis that physicians with large patient lists decrease their intensity of services and bill less per patient to health insurance, and vice versa: physicians with smaller patient lists compensate for the lack of patients with additional visits and services. A second research question relates to the fact that several cantons are allowing physicians to directly dispense drugs to patients ('self-dispensation') whereas …

An Archaeal Trna-Synthetase Complex That Enhances Aminoacylation Under Extreme Conditions, Vlatka Godinic-Mikulcic, Jelena Jaric, Corinne D. Hausmann, Michael Ibba, Ivana Weygand-Durasevic

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetases (aaRSs) play an integral role in protein synthesis, functioning to attach the correct amino acid with its cognate tRNA molecule. AaRSs are known to associate into higher-order multi-aminoacyl-tRNA synthetase complexes (MSC) involved in archaeal and eukaryotic translation, although the precise biological role remains largely unknown. To gain further insights into archaeal MSCs, possible protein-protein interactions with the atypical Methanothermobacter thermautotrophicus seryl-tRNA synthetase (MtSerRS) were investigated. Yeast two-hybrid analysis revealed arginyl-tRNA synthetase (MtArgRS) as an interacting partner of MtSerRS. Surface plasmon resonance confirmed stable complex formation, with a dissociation constant (KD) of 250 nm. Formation of the MtSerRS·MtArgRS complex …

Infant Pain Management, Breanne Ziraldo

Senior Honors Theses

Emphasis on infant pain management has recently become prominent in the medical field. Though it was once thought that infants do not feel pain or remember pain, this thinking has changed due to recent research on the subject. This research has found that infants’ underdeveloped nervous systems actually leads to increased pain rather than decreased pain as previously thought. Research has also found that there are long-term developmental risks associated with prolonged or unmanaged pain in infancy. However, this has not been applied to clinical practice. Studies show that infants are still being under-medicated, if medicated at all, for painful …

Medical School Watercooler Newsletter - November 21, 2010, Lindsey Lyle

Watercooler Newsletter

This is the November 21, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Orthopaedic Department Receives Gift from HJW Foundation
• Mark your calendars
• Holiday Toy Drive - Donate Today
• Reminder for USA Health & Dental Plan Members

Role Of Alpha 7 Nicotinic Acetylcholine Receptor In Calcium Signaling Induced By Prion Protein Interaction With Stress-Inducible Protein 1, Flavio H. Beraldo, Camila P. Arantes, Tiago G. Santos, Nicolle G. T. Queiroz, Kirk Young, Jane R. Rylett, Regina P. Markus, Marco A. M. Prado, Vilma R. Martins

Anatomy and Cell Biology Publications

The prion protein (PrP(C)) is a conserved glycosylphosphatidyl-inositol-anchored cell surface protein expressed by neurons and other cells. Stress-inducible protein 1 (STI1) binds PrP(C) extracellularly, and this activated signaling complex promotes neuronal differentiation and neuroprotection via the extracellular signal-regulated kinase 1 and 2 (ERK1/2) and cAMP-dependent protein kinase 1 (PKA) pathways. However, the mechanism by which the PrPC-STI1 interaction transduces extracellular signals to the intracellular environment is unknown. We found that in hippocampal neurons, STI1-PrP(C) engagement induces an increase in intracellular Ca(2+) levels. This effect was not detected in PrP(C)-null neurons or wild-type neurons treated with an STI1 mutant unable to …

Aging And Disability Resource Centers (Adrcs): Federal And State Efforts To Guide Consumers Through The Long-Term Services And Supports Maze, Carol O'Shaughnessy

National Health Policy Forum

Since 2003, the U.S. Administration on Aging (AoA) and the Centers for Medicare & Medicaid Services (CMS) have made a series of grants to states to develop Aging and Disability Resource Centers (ADRCs). The ADRC program’s purpose is to help people of all ages, disabilities, and income levels more easily access long-term services and supports through single points of entry, make more efficient use of care options, and maximize the services available. Almost $111 million in joint AoA-CMS funding has been devoted to the ADRC initiative since its inception in fiscal year 2003. As of October 2010, 325 ADRC sites …

Attitudes Of Health Professionals To Electronic Data Sharing Within An Integrated Care Electronic Health Record (Icehr), Charyl O'Malley, Damon Berry, Mary Sharp

Conference Papers

It is estimated that 98,000 people die in hospitals yearly in the USA as a result of medical errors (Agency for Healthcare Research and Quality, 2009). Electronic Health Records (EHR) can offer improved patient safety. EHRs are being implemented by many countries, however, not all health professionals have welcomed them (MORI Social Research Institute, 2006). As outlined in the National Health Information Strategy (NHIS) document, Ireland has plans to introduce an EHR. Attitudes of health professionals are a significant factor for the successful implementation and adoption of a new clinical information system. This study aimed to gauge the attitude of …

Portable Ultrasonography In Mass Casualty Incidents: The Caveat Examination, Stanislaw P. Stawicki, James M. Howard, John P. Pryor, David P. Bahner, Melissa L. Whitmill, Anthony J. Dean

Department of Surgery Faculty Publications

Ultrasonography used by practicing clinicians has been shown to be of utility in the evaluation of time-sensitive and critical illnesses in a range of environments, including pre-hospital triage, emergency department, and critical care settings. The increasing availability of light-weight, robust, user-friendly, and low-cost portable ultrasound equipment is particularly suited for use in the physically and temporally challenging environment of a multiple casualty incident (MCI). Currently established ultrasound applications used to identify potentially lethal thoracic or abdominal conditions offer a base upon which rapid, focused protocols using hand-carried emergency ultrasonography could be developed. Following a detailed review of the current use …

Today - November 17, 2010, Loma Linda University

TODAY

Inside this issue:

-- Festivities mark 20th anniversary of Proton Treatment Center
-- National association honors allied health professor and alumna
-- School of Nursing faculty member honored
-- It's better at the beach
-- Students and faculty celebrate National Allied Health Professions Week
-- Students and faculty provide medical support in Port-au-Prince, Haiti
-- Gung-ho Gang takes the Southwest by storm
-- LLUMC chaplain's commission/ordination culminates a personal spiritual journey
-- 'Loma Linda 360°' new season to air

Symptomatic Progression Of Asymptomatic Rotator Cuff Tears A Prospective Study Of Clinical And Sonographic Variables, Nathan A. Mall, H. Mike Kim, Jay D. Keener, Karen Steger-May, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Ken Yamaguchi

Open Access Publications

No abstract provided.

In Case Of Emergency: Implementing Disaster Clauses In Publisher Contracts, Joanne Romano

Library Staff Publications

Joanne Romano, Licensing and Serials Librarian for The Texas Medical Center Library, presented “In Case of Emergency--Implementing Disaster Clauses in Publisher Contracts”  to the  National Network of Libraries of Medicine/Southeastern/Atlantic Region’s Emergency Response and Preparedness Advisory Committee, (NN/LM-SE/A ERAC) on November 17, 2010, in St. Petersburg, FLA at the Marriott Vinoy Renaissance Resort.  Included were slides of the devastation after the 8.8 magnitude earthquake in the Maule region of Chile, how The TMC Library assisted, lessons learned, and advice for how to include disaster clauses in publisher licenses. The  NN/LM-SE/A ERAC group invited Ms. Romano to present at their bi-meeting …

Self-Protecting Bactericidal Titanium Alloy Surface Formed By Covalent Bonding Of Daptomycin Bisphosphonates., Chang-Po Chen, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

Infections are a devastating complication of titanium alloy orthopedic implants. Current therapy includes antibiotic-impregnated bone cement and antibiotic-containing coatings. We hypothesized that daptomycin, a Gram-positive peptide antibiotic, could prevent bacterial colonization on titanium alloy surfaces if covalently bonded via a flexible, hydrophilic spacer. We designed and synthesized a series of daptomycin conjugates for bonding to the surface of 1.0 cm² Ti6Al4V foils through bisphosphonate groups, reaching a maximum yield of 180 pmol/cm². Daptomycin-bonded foils killed 53 ± 5% of a high challenge dose of 3 × 10⁵ cfu Staphylococcus aureus ATCC 29213.

Exposition Au Béryllium Des Travailleurs De La Transformation D'Aluminium Et Du Magnésium : Évaluation Des Paramètres De Surveillance Environnementale, Chantal Dion, Stéphanie Viau, André Dufresne, Yves Cloutier, Guy Perrault

Rapports de recherche scientifique

En 1999, on a constaté un nombre important de réclamations pour des maladies professionnelles reliées à l’exposition au béryllium (Be). Le réseau de la santé mène depuis des interventions dans des établissements de secteurs d’activités ciblés afin de mieux caractériser cette exposition dans ces milieux et d’estimer le nombre de travailleurs potentiellement à risque. C’est dans ce contexte que les auteurs ont exploré la possibilité de suggérer un paramètre de l’exposition au Be, mieux relié à la sensibilisation à ce métal que la mesure présentement utilisée. Les opérations dans les secteurs prioritaires devraient permettre d’y cerner les niveaux d’exposition, de …

Animal Health Matters, David H. Zeman, Russ Daly

Animal Health MATTERS Newsletter

[Page] 1- Olson Agricultural Analytical Services Laboratory Adapts to South Dakota Needs [Page] 2- Director's Message—Service and Grants [Page] 2- Veterinarian Named 2010 SDSU Distinguished Young Alumnus [Page] 3- Diagnostic Implications Following Use of a New IBR-PI3-BRSV Intranasal Vaccine [Page] 3- Extension Vet receives SDVMA Veterinarian of the Year Award [Page] 6- Survey of the Educational Needs of Animal Health Professionals in South Dakota, Summer 2010 [Page] 7- Certificate Program in Veterinary Preventive Medicine Offered Pieces and Parts [Page] 8- Internet Course Offerings from SDSU for Spring 2011 [Page] 8- VBS Department Faculty Members Update Chinese Delegation on Swine Diseases …

Ada News - 11/15/2010, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Cancer Incidence And Mortality In Indigenous Australians In Queensland, 1997–2006, Suzanne P. Moore, Peter K. O'Rourke, Kylie-Ann Mallitt, Gail Garvey, Adèle C. Green, Michael D. Coory, Patricia C. Valery

Aboriginal Policy Research Consortium International (APRCi)

Objective: To examine cancer incidence and mortality in Indigenous Queenslanders. Design, setting and patients: Assessment of indirectly standardised incidence and mortality ratios for Indigenous Australians in Queensland diagnosed with cancer from 1997 to 2006, compared with the total Queensland population. Main outcome measures: Standardised incidence and mortality ratios. Results: Compared with the total Queensland population, Indigenous Queenslanders had a lower overall incidence of cancer (standardised incidence ratio, 0.79; 95% CI, 0.75–0.82), but a higher incidence of some of the more fatal cancer types. Overall cancer mortality was higher (standardised mortality ratio, 1.36; 95% CI, 1.28–1.45) and similar to rates for …

Cortical Thickness Or Grey Matter Volume? The Importance Of Selecting The Phenotype For Imaging Genetics Studies, Anderson M. Winkler, Peter Kochunov, John Blangero, Laura Almasy, Karl Zilles, Peter T. Fox, Ravi Duggirala, David C. Glahn

School of Medicine Publications

Choosing the appropriate neuroimaging phenotype is critical to successfully identify genes that influence brain structure or function. While neuroimaging methods provide numerous potential phenotypes, their role for imaging genetics studies is unclear. Here we examine the relationship between brain volume, grey matter volume, cortical thickness and surface area, from a genetic standpoint. Four hundred and eighty-six individuals from randomly ascertained extended pedigrees with high-quality T1-weighted neuroanatomic MRI images participated in the study. Surface-based and voxel-based representations of brain structure were derived, using automated methods, and these measurements were analysed using a variance-components method to identify the heritability of these traits …

The Effects Of Gender And Catechol O-Methyltransferase (Comt) Val108/158met Polymorphism On Emotion Regulation In Velo-Cardio-Facial Syndrome (22q11.2 Deletion Syndrome): An Fmri Study, Ioana L. Coman, Matthew H. Gnirke, Frank A. Middleton, Kevin M. Antshel, Wanda Fremont, Anne Marie Higgins, Robert J. Shprintzen, Wendy R. Kates

Communication Disorders Faculty Publications

Velo-cardio-facial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases. Its functional polymorphism Val108/158Met has been shown to affect prefrontal function and working memory and has been associated with emotional dysregulation. We utilized a functional magnetic resonance imaging (fMRI) event-related paradigm to asses COMT genotype and gender-moderated effects on the neural activation that …

Carhsp1 Is Required For Effective Tumor Necrosis Factor Alpha Mrna Stabilization And Localizes To Processing Bodies And Exosomes, Jason R. Pfeiffer, Bethany L. Mcavoy, Ryan E. Fecteau, Kristen M. Deleault, Seth A. Brooks

Dartmouth Scholarship

Tumor necrosis factor alpha (TNF-α) is a critical mediator of inflammation, and its production is tightly regulated, with control points operating at nearly every step of its biosynthesis. We sought to identify uncharacterized TNF-α 3' untranslated region (3'UTR)-interacting proteins utilizing a novel screen, termed the RNA capture assay. We identified CARHSP1, a cold-shock domain-containing protein. Knockdown of CARHSP1 inhibits TNF-α protein production in lipopolysaccharide (LPS)-stimulated cells and reduces the level of TNF-α mRNA in both resting and LPS-stimulated cells. mRNA stability assays demonstrate that CARHSP1 knockdown decreases TNF-α mRNA stability from a half-life (t(1/2)) of 49 min to a t(1/2) …

Medical School Watercooler Newsletter - November 14, 2010, Lindsey Lyle

Watercooler Newsletter

This is the November 14, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Med School Café - Expert Advice for the Community
• Students, Faculty Present Research Projects at 4thAnnual COM Research Forum
• Groundbreaking of USA Children's and Women's Hospital Expansion
• USA Physicians Group - Beyond the Medical Headlines
• Study by Dr. Terrence Tumpey Featured in November Issue of Microbe Magazine

Complete Omental Torsion Associated With Left Inguinal Hernia: Case Report And Review Of The Literature, Patty T. Liu Md, Erik J. Teicher Md, Dale A. Dangleben Md

Department of Surgery

No abstract provided.

La Prévention Des Intoxications Dans Les Silos À Fourrage, Ali Bahloul, Brigitte Roberge, Nicole Goyer, Mauricio Chavez, Marcelo Reggio

Rapports de recherche scientifique

Le fourrage conservé dans des silos à tour conventionnels subit une fermentation. Or, ce processus génère des gaz toxiques à des concentrations susceptibles de causer des intoxications graves, pouvant entraîner la mort. En raison de l’insuffisance d’oxygène et de la présence de ces gaz, il est difficile de déterminer le moment où l’atmosphère interne est salubre. La ventilation demeurant le meilleur moyen d'assurer la salubrité de ces espaces clos, les auteurs ont documenté la période critique de la fermentation du fourrage et de la production de gaz toxiques dans une situation spécifique. Ils ont ensuite formulé des recommandations sur la …

Caval Agenesis With Hypoplastic Left Kidney In A Trauma Patient On Warfarin For Deep Vein Thrombosis (Poster), Ryan A. Lawless Md, Dale A. Dangleben Md

Department of Surgery

No abstract provided.

Growing Organizational Capacity To Facilitate The Streamlining Of Patients With Psychiatric Disorders In A Community Academic Health Network; An Eight Year Review, Edward R. Norris Md, Fapa, Fapm, Michael W. Kaufmann Md, David B. Burmeister Do, Muhamad Aly Rifai Md, Laurence P. Karper Md, Ralph A. Primelo Md

Department of Psychiatry

No abstract provided.

Patients’ Knowledge And Attitudes Toward Psychiatric Medication On Admission To An Inpatient Behavioral Health Unit, Krina H. Patel Pharmad, Edward R. Norris Md, Fapa, Fapm, Julia R. Correll Ba, Laurence P. Karper Md, Mary Ellen O'Connell Rn, Msn, Mba, Michael Kaufmann Md

Department of Psychiatry

No abstract provided.

An Evaluation Of An Educational Program On Stigma In Mental Illness Presented By A Mental Health Consumer And Advocate, Edward R. Norris Md, Fapa, Fapm, Karen Burke Rn, Bsn, Brooke Katz Rn, Bsn, Bruce Curry Lcsw, Michael Kaufmann Md

Department of Psychiatry

No abstract provided.

T-Lymphocyte Responses To Intestinally Absorbed Antigens Can Contribute To Adipose Tissue Inflammation And Glucose Intolerance During High Fat Feeding, Yuehui Wang, Jianing Li, Lihua Tang, Yu Wang, Richard Charnigo, Willem De Villiers, Erik Eckhardt

Internal Medicine Faculty Publications

BACKGROUND: Obesity is associated with inflammation of visceral adipose tissues, which increases the risk for insulin resistance. Animal models suggest that T-lymphocyte infiltration is an important early step, although it is unclear why these cells are attracted. We have recently demonstrated that dietary triglycerides, major components of high fat diets, promote intestinal absorption of a protein antigen (ovalbumin, "OVA"). The antigen was partly transported on chylomicrons, which are prominently cleared in adipose tissues. We hypothesized that intestinally absorbed gut antigens may cause T-lymphocyte associated inflammation in adipose tissue.

METHODOLOGY/PRINCIPAL FINDINGS: Triglyceride absorption promoted intestinal absorption of OVA into adipose tissue, …

Supernumerary, Ectopic Tooth In The Maxillary Antrum Presenting With Recurrent Haemoptysis., Taimur Saleem, Umair Khalid, Anam Hameed, Shehzad Ghaffar

Section of Otolaryngology, Head & Neck Surgery

Ectopic eruption of teeth in non-dental sites is a rare phenomenon and can present in a variety of ways such as chronic or recurrent sinusitis, sepsis, nasolacrimal duct obstruction, headaches, ostiomeatal complex disease and facial numbness. However, presentation of such Patients with recurrent haemoptysis has not been described in the literature so far. We have described a case of an ectopic, supernumerary molar tooth in the maxillary antrum in a Patient who initially presented with haemoptysis. A 45-year-old male presented with a 2-month history of episodic haemoptysis. A pedunculated growth from the inferior nasal turbinate was seen with fibre-optic visualization. …

Concurrent Validation Of The Dash And The Quickdash In Comparison To Neck-Specific Scales In Patients With Neck Pain, Saurabh Mehta, Joy Macdermid, Lisa Carlesso, Colleen Mcphee

Physical Therapy Faculty Research

Study Design. Concurrent validity study.

Objective. To examine the validity of the Disabilities of Arm, Shoulder, and Hand (DASH) and the QuickDASH in patients with neck pain in comparison with the Neck Disability Index (NDI), the Cervical Spine Outcome Questionnaire (CSOQ), and the Visual Analogue Scale (VAS) for pain. To examine the agreement between the DASH and the QuickDASH and assess whether the QuickDASH can be used instead of full DASH in patients with neck pain.

Summary of Background Data. NDI is commonly used for measuring neck-related disability in patients with neck pain; but it does not offer to assess …

Community-Based Intervention Packages For Reducing Maternal And Neonatal Morbidity And Mortality And Improving Neonatal Outcomes, Zohra S. Lassi, Batool A. Haider, Zulfiqar Ahmed Bhutta

Woman and Child Health

Background: While maternal, infant and under-five child mortality rates in developing countries have declined significantly in the past two to three decades, newborn mortality rates have reduced much more slowly. While it is recognised that almost half of the newborn deaths can be prevented by scaling up evidence-based available interventions such as tetanus toxoid immunisation to mothers, clean and skilled care at delivery, newborn resuscitation, exclusive breastfeeding, clean umbilical cord care, management of infections in newborns, many require facility based and outreach services. It has also been stated that a significant proportion of these mortalities and morbidities could also be …