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Ohio Academy Of Medical History Annual Meeting Program, April 10, 2010, Ohio Academy Of Medical History

Annual Conference Programs

This tri-fold program is from the annual meeting of the Ohio Academy of Medical History held on April 10, 2010 at the University of Cincinnati Vontz Center in Cincinnati, Ohio. The program details the events and presentations of the meeting.

Evaluating Forensic Dna Evidence, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.

Establishing Parameters For Objective Interpretation Of Dna Profile Evidence, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.

Health Care Reform's Proposed End-Of-Life Provisions, Brandy C. Hill, Nick Lebredo, Christopher R. Shafer

Florida Public Health Review

End-of-life planning promotes patient autonomy by allowing individual patients to inform and direct care givers and healthcare proxies on their desired level of end-of-life care, where the patient prefers to pass away (whether at home or in a hospital setting), and the methods and levels of pain management that the patient deems desirable. Given that, it is counter-intuitive that a significant majority of American's fail to execute, or fail to properly execute, advance directives. Theauthor’seffortsfocusonwhatcanbedonetoimprove,generally,end-of-lifecare. Tothatend,theauthorsconclude that improvements in end-of-life care must be achieved at three levels: the individual level, the healthcare provider level, andatthegovernmentlevel. Ontheindividuallevel,patientsmustassumegreateraccountabilityfortheirownend-of-life care. Thatentailsmakingone'swishesforend-of-lifecareknowntofamilymembersandhealthcareproviders. Onthe healthcare …

Factors Associated With Institutionalization For Treatment Of Active Tuberculosis: A Synopsis From In-Depth Patient Interviews, Robert J. Mcdermott, Carol A. Bryant, Jeannine Coreil, Aimee R. Eden, Lori K. Buhi

Florida Public Health Review

To increase the effectiveness of therapeutic regimens for tuberculosis (TB) and to reduce the societal risks for both infected and uninfected individuals, it is beneficial to be able to predict factors associated with non-adherence to treatment. The purpose of this study was to acquire detailed case histories of TB patients admitted to a hospital setting and to gain a better understanding of how patients explain the life events leading up to their admission for treatment. Twenty-one patients with active TB were interviewed concerning their knowledge of TB, diagnosis and treatment history, recent history prior to hospitalization, reactions to and life …

Optimization Algorithms For Functional Deimmunization Of Therapeutic Proteins, Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chris Bailey-Kellogg

Dartmouth Scholarship

To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived from the foreign protein. Thus, developing minimal-epitope variants represents a powerful approach to deimmunizing protein therapeutics. Critically, mutations selected to reduce immunogenicity must not interfere with the protein's therapeutic activity.

The Clinical Utility Of Molecular Typing Of Multiply-Resistant Pseudomonas Aeruginosa In Children With Cystic Fibrosis, Ruth Ann Luna

Theses and Dissertations

Chronic infection with P. aeruginosa is expected in patients with cystic fibrosis (CF), but the ability to delay, prevent, or better manage infection with multiply-resistant P. aeruginosa (MRPA) can potentially increase quality of life and extend survival. The Texas Children’s Hospital CF Care Center has identified an endemic MRPA strain (dominant clone), and this study aimed to identify risk factors for acquisition of the clone as well as determine differences in patient outcome associated with subsequent infection with the clone. The study included 71 patients with CF with documented MRPA infection. Designation of patients as members of the dominant clone …

Living On Autopilot: How Your Brain Thinks For You, Andrea Stathopoulos '10

Honor Scholar Theses

One way in which humans are set apart from other animals is by our impressive intellectual capacities. Humans are commonly considered to be true masters of rational, conscious control over our actions. However, that feeling of control may be mostly illusory. Accumulating evidence suggests that unconscious cognitive processes can account for much of human behavior. Homeostasis is a clear example of the evolutionary benefit of automation, allowing valuable energy and limited attention to be diverted elsewhere. I instead want to focus on the automaticity of more complicated behaviors, ones that are typically thought to require a large amount of cognitive …

Stigma And Therapy Completion For Latent Tuberculosis Among Haitian-Origin Patients, Jeannine Coreil, Michael Lauzardo, Heather Clayton

Florida Public Health Review

A prospective cohort study of LTBI treatment conducted within the Haitian population of South Florida investigated the predictive association between illness-related stigma among patients near the beginning of treatment and completion of preventive therapy. Factors associated with perceived stigma were also investigated. Ninety patients from Broward and Palm Beach counties were administered a questionnaire that included items related to illness history, perceptions and understanding of latent tuberculosis, and a 25-item stigma scale adapted from previously developed measures of tuberculosis-related stigma. Therapy completion was determined through a follow-up chart review. Data analyses compared patients who completed therapy with those who defaulted …

Diagnosing Decisions: An Examination Of Medical Career Choices And Their Effects On The Health Care System, Nicole Craker '10

Honor Scholar Theses

With the passage of the new health care bill in March of this year, President Obama was able to promise health care coverage to millions of Americans (Health Reform, 2010). While this was a major step towards increasing the health of our nation, promise of coverage does not automatically equate with the promise of better health. Rather, the expanded coverage may more significantly correlate with expanded physician wait lists. As newly insured Americans attempt to make appointments, they may have a difficult time finding a physician who has the time to take them due to a shortage of available doctors. …

Preoperative Drainage In Pancreatic Cancer., Eugene P Kennedy, Ernest L Rosato, Charles J Yeo

Department of Surgery Faculty Papers

Van der Gaag et al. conclude that preoperative biliary drainage in patients undergoing surgery for cancer of the head of the pancreas increases complications. Previous studies have shown that stenting is associated with a doubling in the risk of wound infection and an overall slightly increased risk of any complication.

Perifosine, A Novel Akt Inhibitor Induces Apoptosis, Cell Cycle Arrest And Has A Chemo-Sensitizing Effect In Medulloblastoma Cell Lines, Anil Kumar

Theses and Dissertations

Primary central nervous system (CNS) tumors are the most common solid tumors found in children. While surgery and radiotherapy still remain the standard treatment modalities in pediatric brain tumors, chemotherapy also has an important part in the management of these tumors. However, most of the available chemotherapeutic drugs have suboptimal effectiveness. Deregulation of various pro-apoptotic and anti-apoptotic pathways has been cited as a major mechanism underlying this drug resistance. The role of various serine threonine kinases, including Akt kinases, in promoting drug resistance is being extensively studied in various cancers. A complete understanding of the molecular mechanisms that underlie drug …

Methods And Compositions For Optimizing Blood And Tissue Stability Of Camptothecin And Other Albumin-Binding Therapeutic Compounds, Thomas G. Burke, Daniel C. Carter

Pharmaceutical Sciences Faculty Patents

The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin. The invention involves methodologies and formulations that limit human serum albumin-mediated reduction of the anti-cancer and anti-HIV effects of the camptothecins, and the methods and formulations provide combination therapies in which binding of the camptothecin agent to human serum albumin can be modulated by the administration of a competing agent that also binds human serum albumin. Reduced camptothecin drug binding to human serum albumin can result in elevated camptothecin free drug levels …

Rituximab In The Treatment Of B-Cell Non-Hodgkin Lymphoma, Focus On Outcomes And Comparative Effectiveness, Firas Badin, John Hayslip

Markey Cancer Center Faculty Publications

Rituximab is an important and well established component in the treatment of many patients with B-cell non-Hodgkin lymphoma. In this paper we review recent clinical trials investigating the addition of rituximab to standard chemotherapy regimens for treatment of patients with diffuse large B cell lymphoma and follicular lymphoma. This report focuses upon treatment efficacy, quality of life, and safety of rituximab or rituximab-containing regimens. More uniquely, we review economic aspects of lymphoma treatments, including the cost of standard chemotherapy regimens with or without rituximab, cost effectiveness of rituximab in both induction and maintenance treatment, and lymphoma's impacts on patient's productivity …

All- Star Sports Honors Analysis, Daniel Reed

Undergraduate Theses and Capstone Projects

As requested, I have read and analyzed the case, “Decision Making at the Top: The All- Star Sports Catalog Division.” This case detailed an issue that many organizations face at some point as many organizations tend to make changes to its decision making process. The All-Star Sports Catalog Division (ASC) is one of three divisions within the All-Star Sports organization. Since its establishment in 1990, the division has performed well and expanded greatly. Much of this success resulted from the decision making process developed by ASC President, Don Barrett. The process is very fundamental and wellstructured, which has allowed the …

Ada News - 04/05/2010, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Information And Incentives: Improving The Health Of New York City's Low-Income Population, Kathryn Linehan, Lisa Sprague

National Health Policy Forum

The National Health Policy Forum sponsored a site visit to New York City (NYC) in April 2010 to explore health care delivery for Medicaid beneficiaries and the uninsured in New York City’s hospital-dominated market. New York offers real-time examples of government policy and provider initiatives in health information technology (IT) and quality improvement being played out on a large, complex, and dynamic stage with multiple stakeholders. Site visit participants heard from providers and others who discussed efforts to improve the quality of care for low-income New Yorkers through a variety of methods, such as the adoption and use of electronic …

U.N. Role Offers Ioc Chance To Place Sport Amid Global Priorities, Rick Burton, Norm O'Relly

Sport Management - All Scholarship

No abstract provided.

Medical School Watercooler Newsletter - April 4, 2010, Lindsey Lyle

Watercooler Newsletter

This is the April 4, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• RSVP Today Online - Limited Seating For April Conferences
• Urgent Care - Appointments Never Necessary
• International Diabetes Researcher To Speak
• USA Birth Defects Research Published In AAP Journal

Aspergillus Fumigatus Stimulates The Nlrp3 Inflammasome Through A Pathway Requiring Ros Production And The Syk Tyrosine Kinase, Najwane Saïd-Sadier, Eduardo V. Padilla, Gordon Langsley, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Invasive aspergillosis (IA) is a life-threatening disease that occurs in immunodepressed patients when infected with Aspergillus fumigatus. This fungus is the second most-common causative agent of fungal disease after Candida albicans. Nevertheless, much remains to be learned about the mechanisms by which A. fulmigatus activates the innate immune system. We investigated the inflammatory response to conidia and hyphae of A. fumigatus and specifically, their capacity to trigger activation of an inflammasome. Our results show that in contrast to conidia, hyphal fragments induce NLRP3 inflammasome assembly, caspase-1 activation and IL-1β release from a human monocyte cell line. The ability of Aspergillus …

Mental Health, Naturally: The Family Guide To Holistic Care For A Healthy Mind And Body, P. S. Mcmillen

Library Faculty Research

Inspite of its rather intimidating size, this is a very readable book on the entire gamut of holistic approaches — everything from nutrition to magnets — for treating some of the most prevalent mental health issues.

Section Abstracts: Medical Science

Virginia Journal of Science

Abstracts of the Medical Sciences Section for the 88th Annual Meeting of the Virginia Academy of Science, May 20-21, 2010, James Madison University, Harrisonburg, Virginia.

Proceedings From The Second Annual Boonshoft School Of Medicine Medical Student Research Symposium, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Second Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 1, 2010.

Uconn School Of Medicine Dean's Newsletter, Spring 2010, Cato T. Laurencin

Annual Reports - Education

In the mid-90’s, the UConn School of Medicine made several innovative changes to its curriculum that emphasized the development of clinical skills and problem-based learning. One of the hallmarks of the curriculum is the Student Continuity Practice, a program that places students as early as the first month of their first year, in community-based primary care offices. For the next three years, students spend time in that office, observing and learning the nuances and art of primary care medicine.

This is part of UConn’s overall strategy to prepare graduates for all facets of medicine, including primary care. Through the years, …

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly By Mediating Hormone Signaling, Richard G. Stevens

UCHC Articles - Research

As transcriptional regulators, circadian genes have the potential to influence a variety of biological pathways, including many cancer-related processes. Cryptochrome 2 (CRY2) is essential for proper circadian timing, and is a key component of the circadian regulatory feedback loop. Here, we report findings from genetic, epigenetic, loss-of-function, and transcriptional profiling analyses of CRY2 in breast cancer. Six SNPs in CRY2 were identified for genotyping in a case-control population (N=441 cases and N=479 controls), and three SNPs (rs11038689, rs7123390, and rs1401417) were significantly associated with postmenopausal breast cancer risk, with significant effect modification by menopausal status (dominant model for …

Standardized Performance Measurement And Reporting In Emergency Departments (Eds), Gw Urgent Matters Learning Network Ii

Health Workforce Research Center Publications

The drive to maximize emergency department (ED) efficiency while also ensuring the quality of care they deliver has been the focus of experts in the United States for decades. Access to patient-centered and equitable emergency care is critical to a community, and EDs are the safety net that must provide that care whenever it is needed, to whomever needs it. A wellmanaged ED increases the quality and safety of patient care and strengthens the health care infrastructure.

Com Outlook Spring 2010, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Higher Bmc And Areal Bmd In Children And Grandchildren Of Individuals With Hip Or Knee Replacement, Bonny L. Specker, Howard E. Wey, Teresa L. Binkley, Tianna M. Beare, Eric P. Smith, Frank Rauch

Ethel Austin Martin Program Publications

The relationship between aBMD and osteoarthritis (OA) remains unclear. We compared aBMD, BMC and bone size among children and grandchildren of Hutterites with hip or knee replacement (n=23 each) to children and grandchildren of age- and sex-matched controls (178 children and 267 grandchildren). There were no differences in anthropometric measures or activity levels between case and control probands, but femoral neck (FN) and spine (LS) aBMD and Z-scores were greater in cases than controls (0.89 vs. 0.80 g/cm2; 1.15 vs. 1.03 g/cm2; 1.5 vs. 0.8; 2.4 vs. 1.2: all por =2 years post-menarcheal or males> or =18 years): 33 were …

Dental Care For Underserved Children, Crystal Bryant, Jon Dunn, Heather Gagliano, Diane Kenski, Amber Lords, Thomas Marley, Jason Oakes, De Edra Price, Tracey Price, Kim Thomas, Karin Waltz

Service-Learning Program

Service Project Purpose: We identified dentists in the Central District Health Department region who perform fluoride varnish on underserved children aged 3 and under. The information was formatted into a usable database, separated by zip code. A map, identifying locations of those dentists in District 4, was created. Learning goals: Apply basic concepts of population-focused practice to client situations, and perform targeted community assessments centered on an identified need of an agency working with a population. Implement short-term interventions and make recommendations for short and long-range goals and interventions for the agency/population.

Fit And Fall Proof Program, Anne Lawler, Mallory Radford, Monica Stoddard, Hannah Woodell, Jennifer Wight, Julie Carr, Suzy Sakadales, Lisa Price, Christina Bobek, Jenny Gould, Omar Jimenez, Cory Louie

Service-Learning Program

Service Project Purpose: Continue with health promotion and determine reason for low attendance at the Boise Senior Activities Center (BSAC) location. Learning Goals: Practice skills required by professional nurses working in community and public health. Apply basic concepts of population-focused practice to client situations, and perform targeted community assessments centered on an identified need or question of a population or agency working with a population.