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2010

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Articles 1981 - 2010 of 5702

Full-Text Articles in Medicine and Health Sciences

Review Of: A Practical Approach To Analyzing Healthcare Data, Lashunda B. Smith Jul 2010

Review Of: A Practical Approach To Analyzing Healthcare Data, Lashunda B. Smith

Internet Journal of Allied Health Sciences and Practice

No abstract provided.


Noxa Mediates Hepatic Stellate Cell Apoptosis By Proteasome Inhibition., Ivette M. Sosa Seda, Justin L. Mott, Yuko Akazawa, Fernando J. Barreyro, Steven F. Bronk, Scott H. Kaufmann, Gregory J. Gores Jul 2010

Noxa Mediates Hepatic Stellate Cell Apoptosis By Proteasome Inhibition., Ivette M. Sosa Seda, Justin L. Mott, Yuko Akazawa, Fernando J. Barreyro, Steven F. Bronk, Scott H. Kaufmann, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

Aim: Induction of hepatic stellate cell (HSC) apoptosis is a viable therapeutic strategy to reduce liver fibrogenesis. Although BH3-only proteins of the Bcl-2 family trigger pro-apoptotic pathways, the BH3-only proteins mediating HSC apoptosis have not been well defined. Our aim, using proteasome inhibition as a model to induce HSC apoptosis, was to examine the BH3-only proteins contributing to cell death of this key liver cell subtype. Methods: Apoptosis was induced by treating LX-2 cells, an immortalized human hepatic stellate cell line, and primary rat stellate cells with the proteasome inhibitor MG-132. Results: Treatment with proteasome inhibitors increased expression of Noxa …


Breast Cancer Dna Methylation Profiles Are Associated With Tumor Size And Alcohol And Folate Intake, Brock C. Christensen, Karl T. Kelsey, Shichun Zheng, E. Andres Houseman, Carmen J. Marsit, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas Jul 2010

Breast Cancer Dna Methylation Profiles Are Associated With Tumor Size And Alcohol And Folate Intake, Brock C. Christensen, Karl T. Kelsey, Shichun Zheng, E. Andres Houseman, Carmen J. Marsit, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas

Dartmouth Scholarship

Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors from 162 (AJCC stage I-IV) women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpG loci associated with 773 cancer-related genes and validated select CpG loci with Sequenom EpiTYPER. Tumor grade, size, estrogen and progesterone receptor status, and triple negative status were significantly (Q-values <0.05) associated with altered methylation of 209, 74, 183, 69, and 130 loci, respectively. Unsupervised clustering, using a recursively partitioned mixture model (RPMM), of all autosomal CpG loci revealed eight distinct methylation classes. Methylation class membership was significantly associated with patient race (P<0.02) and tumor size (P<0.001) in univariate tests. Using multinomial logistic regression to adjust for potential confounders, patient age and tumor size, as well as known disease risk factors of alcohol intake and total dietary folate, were all significantly (P<0.0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns.


New Mothers' Perceptions Of Their First Encounter With A Health Care Provider, Katherine Ure Jul 2010

New Mothers' Perceptions Of Their First Encounter With A Health Care Provider, Katherine Ure

Master's Theses or Doctor of Nursing Practice

Since its genesis, health care has been developing and evolving to meet the needs of the population it serves. Hospital length of stay after childbirth has progressively decreased over the past 29 years initially in response to public pressure to reduce the medical aspect of childbirth. More recently, the decrease in length of stay has accelerated in response to cost-containment pressures (Eaton, 2001). This investigation examined new mothers’ perceptions of their maternal role attainment through their initial interaction with a health care provider. Ramona Mercer (1990) stated in Parents at Risk that there is a pressing need to facilitate early …


White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold Jul 2010

White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold

Neurology Faculty Publications

Increased white matter mean diffusivity and decreased fractional anisotropy (FA) has been observed in subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). We sought to determine whether similar alterations of white matter occur in normal individuals at risk of AD. Diffusion tensor images were acquired in 42 cognitively normal right-handed women with both a family history of dementia and at least one apolipoprotein E4 allele. These were compared with images from 23 normal women without either AD risk factor. Group analyses were performed using tract-based spatial statistics. Reduced FA was observed in the fronto-occipital and inferior temporal …


Modification And Implementation Of Nccn Guidelines On Prostate Cancer In The Middle East And North Africa Region., Waleed A. Hassen, Farrok A. Karsan, Farhat Abbas Jul 2010

Modification And Implementation Of Nccn Guidelines On Prostate Cancer In The Middle East And North Africa Region., Waleed A. Hassen, Farrok A. Karsan, Farhat Abbas

Department of Surgery Docs

Abstract

A prostate cancer committee was established to modify the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Prostate Cancer for adaptation and implementation in the Middle East and North Africa (MENA) region. The objective was to enhance the multidisciplinary approach to the treatment of prostate cancer. The committee, comprising regional experts in the fields of urologic, medical, and radiation oncology, reviewed the 2009 version of the NCCN Guidelines on Prostate Cancer and suggested modifications based on the unique needs of the regions determined through published evidence and local expertise. The committee identified several areas in the NCCN Guidelines …


Food Handling Practices, Knowledge And Beliefs Of Families With Young Children Based On The Health Belief Model, Adeline Lum Jul 2010

Food Handling Practices, Knowledge And Beliefs Of Families With Young Children Based On The Health Belief Model, Adeline Lum

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Objective: To determine current food handling practices, knowledge and beliefs of primary food handlers with children 10 years old and the relationship between these components.

Design: Surveys were developed based on FightBac!™ concepts and the Health Belief Model (HBM) construct.

Participants: The majority of participants (n= 503) were females (67%), Caucasians (80%), aged between 30 to 49 years old (83%), had one or two children (83%), prepared meals all or most of the time (76%) and consumed meals away from home three times or less per week (66%).

Analysis: Descriptive statistics and inferential statistics using Spearman’s rank correlation coefficient (rho) …


A Current Examination Of Dietary Intakes Of Fiber, Calcium, Iron, And Zinc And Their Relationship To Blood Lead Levels In U.S. Children Aged 1–5 Years, Stephanie A. Melchert Jul 2010

A Current Examination Of Dietary Intakes Of Fiber, Calcium, Iron, And Zinc And Their Relationship To Blood Lead Levels In U.S. Children Aged 1–5 Years, Stephanie A. Melchert

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

A CURRENT EXAMINATION OF DIETARY INTAKES OF FIBER, CALCIUM, IRON, AND ZINC AND THEIR RELATIONSHIP TO BLOOD LEAD LEVELS IN U.S. CHILDREN AGED 1-5 YEARS Stephanie Ann Melchert, M.S. University of Nebraska, 2010 Adviser: Kaye Stanek Krogstrand The effect of lead on the health and well-being of those exposed has been well documented and many efforts have been made to reduce exposure of lead to the United States population. Despite these efforts, many studies have documented cognitive impairments and behavioral problems in children with even low levels of lead in their blood. Previous studies have suggested that a proper diet …


Holocarboxylase Synthetase-Dependent Biotinylation Of Histone H4, Luisa F. Rios Avila Jul 2010

Holocarboxylase Synthetase-Dependent Biotinylation Of Histone H4, Luisa F. Rios Avila

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4. Histone biotinylation marks play important roles in the repression of genes and retrotransposons. Preliminary studies suggested that K16 in histone H4 is a target for biotinylation by HCS. Here we demonstrated that H4K16bio is overrepresented in repeat regions {pericentromeric alpha satellite repeats; long terminal repeats (LTR)} compared with euchromatin promoters. H4K16bio was also enriched in the repressed interleukin-2 gene promoter. The enrichment at LTR22 and promoter 1 of the sodium-dependent multivitamin transporter (SMVT) depended on biotin supply; and was significantly lower in fibroblasts …


Mammographic Parenchymal Patterns Of 1,666 Thai Women : A Mammographic Screening Evaluation, D Boonjunwetwat, A. Thakhulee, J. Prueksadee Jul 2010

Mammographic Parenchymal Patterns Of 1,666 Thai Women : A Mammographic Screening Evaluation, D Boonjunwetwat, A. Thakhulee, J. Prueksadee

Chulalongkorn Medical Journal

Introduction : Breast density, a measure of the extent of radiodense fibroglandular tissue in the breast, has a potentiality to be used as a predictor for breast cancer. We assessed breast density in Thai women using Wolfe's parenchymal patterns which is one of the most reliable methods for the evaluation. Objective : To assess breast parenchymal patterns of Thai women. Setting : King Chulalongkorn Memorial Hospital. Research design : Retrospective study. Patients : Women who underwent mammogram screening from July to December 2002 at King Chulalongkorn Memorial Hospital (KCMH). Methods : Normal mammograms of the screening women were reviewed for …


Right Ventricular Mass Detected By Cardiovascular Magnetic Resonance Imaging, M. Tumkosit Jul 2010

Right Ventricular Mass Detected By Cardiovascular Magnetic Resonance Imaging, M. Tumkosit

Chulalongkorn Medical Journal

urpose : Right ventricular (RV) mass is very uncommon. We retrospectively reviewed characteristics of RV mass detected by cardiovascular magnetic resonance imaging (CMR). Objective : To describe types of RV mass, magnetic resonance (MR) signal intensity, and enhancement of RV mass in CMR. Setting : King Chulalongkorn Memorial Hospital, a large medical school, tertiary care and cardiac center for treatment of heart diseases in Thailand. Research design : Retrospective review. Methods : CMR studies during Jan 1st, 2007 to July 31st, 2009 were reviewed. All patients who had RV mass were recruited. CMR findings were correlated with operative notes, pathology …


Mammographic Breast Parenchymal Patterns In Thai Women With Breast Cancers, D Bunjunwetwat, N. Dumrongpisutikul Jul 2010

Mammographic Breast Parenchymal Patterns In Thai Women With Breast Cancers, D Bunjunwetwat, N. Dumrongpisutikul

Chulalongkorn Medical Journal

Introduction : Dense breast parenchyma are reported as increasing risk of breast cancer from the previously study. The dense breasts have a role to consider additional MRI to the screening mammogram for early detection in women with moderately increased breast cancer risk. Objective : To assess breast parenchymal patterns of Thai women with breast cancers. Setting : King Chulalongkorn Memorial Hospital Research design : A retrospective study. Patients : Thai women who had verified of breast cancers and had bilateral mammography in King Chulalongkorn Memorial Hospital. Methods : Seventy two Thai women with breast cancers were retrospectively reviewed for breast …


Intrathoracic Manifestations Of Lymphoma Detected By Ct, N Piyavisetpat, K Wettawong, T Assanasen, P. Wannakrairot Jul 2010

Intrathoracic Manifestations Of Lymphoma Detected By Ct, N Piyavisetpat, K Wettawong, T Assanasen, P. Wannakrairot

Chulalongkorn Medical Journal

Introduction : Computed tomography (CT) has been frequently supplemented to stage intrathoracic disease, monitor response to treatment, evaluate recurrence, and diagnose complications. Geographic variations in the incidence of malignant lymphoma are well documented. However, there is no radiologic study of intrathoracic disease of lymphoma in Thailand. Objective : To describe intrathoracic diseases of both Hodgkin disease (HD) and non-Hodgkin's lymphoma (NHL) demonstrated on CT. Setting : King Chulalongkorn Memorial Hospital Research design : A retrospective study Patients : Lymphoma patients who obtained chest CT as an initial staging in between January and December 2003. Methods : We reviewed chest CT …


Hepatocellular Carcinoma In Cirrhotic Liver: Ct Findings And The Usefulness Of Delayed Phase Scan, R Chaodumrong, N Tanpowpong, B. Vachiranubhap Jul 2010

Hepatocellular Carcinoma In Cirrhotic Liver: Ct Findings And The Usefulness Of Delayed Phase Scan, R Chaodumrong, N Tanpowpong, B. Vachiranubhap

Chulalongkorn Medical Journal

Background : Most hepatocellular carcinomas (HCCs) occur in an underlying cirrhotic liver. Some of which are difficult to diagnose because they do not show typical enhancement pattern, and cirrhotic nodules can mimic an HCC. Although multiphasic dynamic computed tomography (CT) has been used for detecting HCC, the usefulness of delayed phase scan is unclear. Objectives : To analyze CT appearances of HCCs and other associated findings in cirrhotic livers, and to determine the usefulness of delayed phase scan for detecting HCCs. Setting : Department of Radiology, Faculty of Medicine, Chulalongkorn University Research design : Retrospective study Materials and Methods : …


Idiopathic Granulomatous Mastitis: A Case Report, J Prueksadee, D Boonjunwetwat, J. Chayakulkheeree Jul 2010

Idiopathic Granulomatous Mastitis: A Case Report, J Prueksadee, D Boonjunwetwat, J. Chayakulkheeree

Chulalongkorn Medical Journal

Idiopathic granulomatous mastitis is an uncommon benign breast disease diagnosed from exclusion. It mimics malignant breast tumor in terms of clinical and imaging features. We hereby report a case of painful lump in the left breast. Mammograms and ultrasound findings could not exclude malignant mass. Wide excision was performed and the final histopathological diagnosis of granulomatous mastitis was concluded. In conclusion, the clinical and imaging findings of granulomatous mastitis are similar to carcinoma. Tissue diagnosis was very important to distinguish these two entities before starting management and avoiding unnecessary mastectomy.


Clinical Practice Guideline For Contrast Media Administration In Diagnostic Imaging, B Chaopathomkul, K Ruxrungtham, R Leelanukrom, Y Avihingsanon, W Khovidhunkit, S Sunthornyothin, N Rojvachiranonda, J. Opanuraks Jul 2010

Clinical Practice Guideline For Contrast Media Administration In Diagnostic Imaging, B Chaopathomkul, K Ruxrungtham, R Leelanukrom, Y Avihingsanon, W Khovidhunkit, S Sunthornyothin, N Rojvachiranonda, J. Opanuraks

Chulalongkorn Medical Journal

Iodinated contrast media ถูกใช้ในปริมาณที่มากขึ้นตามการเติบโต และขยายตัวอย่าง รวดเร็วของการตรวจทางรังสีวิทยาวินิจฉัย โดยเฉพาะการตรวจด้วยเครื่องเอกซเรย์คอมพิวเตอร์ ในขณะเดียวกัน เราก็ได้เรียนรู้ผลข้างเคียงจากการใช้ iodinated contrast media มากขึ้น ผลข้างเคียง โดยรวมพบได้ 5 - 8 เปอร์เซ็นต์ และมีน้อยกว่า 0.1 เปอร์เซ็นต์ ที่มีอันตรายถึงชีวิต ผลข้างเคียงแบ่ง ได้ว่า เป็นผลข้างเคียงต่อไตหรือต่ออวัยวะอื่น ๆ หรืออาจจะแบ่งเป็นแบบเฉียบพลัน หรือแบบล่าช้า การประเมินผู้ป่วยที่มีความเสี่ยงรวมถึงการจัดการและการรักษาผู้ป่วยเหล่านี้อย่างถูกต้อง และทันท่วง ทีเป็นสิ่งที่สำคัญและเป็นหน้าที่สำหรับรังสีแพทย์และทีม ซึ่งรวมถึงแพทย์เจ้าของไข้ แพทย์ประจำบ้าน พยาบาล นักรังสีการแพทย์ และเจ้าหน้าที่ธุรการที่ทำหน้าที่นัดผู้ป่วย บทความพิเศษเกี่ยวกับแนวทาง ปฏิบัติทางด้านคลินิคสำหรับการฉีด contrast media ฉบับนี้ เกิดจากการรวบรวมทบทวนบทความ ต่าง ๆ ที่เกี่ยวข้องและได้สรุปแนวทางที่เหมาะสมในการจัดการและป้องกันผลข้างเคียงต่าง ๆ ที่จะเกิด จากการใช้ iodinated contrast media.


Depression And On-Line Game Playing Behaviors Of High School Students In Bangkok Metropolitan Area, T Satarpontanasin, D. Kasantikul Jul 2010

Depression And On-Line Game Playing Behaviors Of High School Students In Bangkok Metropolitan Area, T Satarpontanasin, D. Kasantikul

Chulalongkorn Medical Journal

วัตถุประสงค์ : เพื่อศึกษาภาวะซึมเศร้าและพฤติกรรมการเล่นเกมออนไลน์ของนักเรียนมัธยมศึกษาตอนปลายในเขตกรุงเทพมหานครรูปแบบการวิจัย : การวิจัยเชิงพรรณนา ณ จุดเวลาใดเวลาหนึ่งกลุ่มตัวอย่าง : นักเรียนชั้นมัธยมศึกษาตอนปลาย ในสังกัดสำนักงานการศึกษาขั้นพื้นฐานกระทรวงศึกษาธิการในเขตกรุงเทพมหานครวิธีการศึกษา : นักเรียนชั้นมัธยมศึกษาตอนปลายปีการศึกษา 2552 โดยใช้แบบสอบถามข้อมูลส่วนบุคคล แบบทดสอบการติดเกมสำหรับเด็กและวัยรุ่น และแบบสอบถามเกี่ยวกับความรู้สึก CES-D วิเคราะห์ข้อมูลโดยโปรแกรม SPSS สถิตที่ใช้ได้แก่ ค่าร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และวิเคราะห์ความแปรปรวนทางเดียวผลการศึกษา : นักเรียนชั้นมัธยมศึกษาปีที่ 4 จำนวน 257 คน (ร้อยละ 33.3) นักเรียนชั้นมัธยมศึกษาปีที่ 5 จำนวน 255 คน (ร้อยละ 33.1) นักเรียนขั้นมัธยมศึกษาปีที่ 6จำนวน 259 คน (ร้อยละ 33.6) ซึ่งเป็นเพศชายจำนวน 396 คน (ร้อยละ 51.4)และเพศหญิง จำนวน 375 คน (ร้อยละ 48.6) จากการวิจัยพบว่ากลุ่มไม่มีปัญหาใน การเล่นเกม ร้อยละ 86.5 คลั่งไคล้ เริ่มเกิดปัญหาในการเล่นเกม ร้อยละ 9.9กลุ่มติดเกม มีปัญหาในการเล่นเกมมาก ร้อยละ 3.6 ส่วนด้านความรู้สึกพบว่ากลุ่มที่ไม่อยู่ในข่ายภาวะซึมเศร้า ร้อยละ 67.7 ส่วนกลุ่มที่อยู่ในข่ายภาวะซึมเศร้า32.2 และปัจจัยที่เกี่ยวข้องพบว่ามีปัจจัยที่มีผลต่อพฤติกรรมการเล่นเกม ได้แก่เพศชาย ระดับการศึกษาชั้นมัธยมศึกษาปีที่ 5 เกรดเฉลี่ยต่ำ รายได้ส่วนตัวต่ำและสูง จำนวนเพื่อนสนิทเพศเดียวกันน้อย และปัจจัยทางจิตสังคม มีภาวะซึมเศร้า ร้อยละ 32.3สรุปผล : นักเรียนมัธยมศึกษาตอนปลายในโรงเรียนที่ทำวิจัย ส่วนใหญ่ยังไม่มีปัญหาในการเล่นเกม แต่ก็พบว่าปัจจัยที่เกี่ยวข้อกับพฤติกรรมการเล่นเกม ซึ่งควรที่จะได้รับการประเมินและติดตามต่อไปในกลุ่มที่มีปัญหาพฤติกรรมการเล่นเกมและมีภาวะซึมเศร้าร่วมอยู่ด้วย รวมทั้งวางแนวทางความร่วมมือทั้งโรงเรียนและผู้ปกครอง เพื่อที่จะช่วยให้เด็กลดพฤติกรรมการเล่นเกมลงและปฏิกิริยาทางอารมณ์ที่เกิดขึ้น.


Toxicity Of Flow Line, Durafill Vs, And Dycal To Dental Pulp Cells: Effects Of Growth Factors, Alyssa Furey, Julie Hjelmhaug, Doug Lobner Jul 2010

Toxicity Of Flow Line, Durafill Vs, And Dycal To Dental Pulp Cells: Effects Of Growth Factors, Alyssa Furey, Julie Hjelmhaug, Doug Lobner

Biomedical Sciences Faculty Research and Publications

Introduction

The objective was to determine the effects of growth factor treatment on dental pulp cell sensitivity to toxicity of 2 composite restoration materials, Flow Line and Durafill VS, and a calcium hydroxide pulp capping material, Dycal.

Methods

Toxicity of the dental materials to cultures of primary dental pulp cells was determined by the MTT metabolism assay. The ability of 6 different growth factors to influence the toxicity was tested.

Results

A 24-hour exposure to either Flow Line or Durafill VS caused approximately 40% cell death, whereas Dycal exposure caused approximately 80% cell death. The toxicity of Flow Line and …


Synaptotoxicity Of Alzheimer Beta Amyloid Can Be Explained By Its Membrane Perforating Property, Fernando Sepulveda, Jorge Parodi, Robert W. Peoples, Carlos Opazo, Luis G. Aguayo Jul 2010

Synaptotoxicity Of Alzheimer Beta Amyloid Can Be Explained By Its Membrane Perforating Property, Fernando Sepulveda, Jorge Parodi, Robert W. Peoples, Carlos Opazo, Luis G. Aguayo

Biomedical Sciences Faculty Research and Publications

The mechanisms that induce Alzheimer’s disease (AD) are largely unknown thereby deterring the development of disease-modifying therapies. One working hypothesis of AD is that Aβ excess disrupts membranes causing pore formation leading to alterations in ionic homeostasis. However, it is largely unknown if this also occurs in native brain neuronal membranes. Here we show that similar to other pore forming toxins, Aβ induces perforation of neuronal membranes causing an increase in membrane conductance, intracellular calcium and ethidium bromide influx. These data reveal that the target of Aβ is not another membrane protein, but that Aβ itself is the cellular target …


Involvement Of Noradrenergic Neurotransmission In The Stress- But Not Cocaine-Induced Reinstatement Of Extinguished Cocaine-Induced Conditioned Place Preference In Mice: Role For Β-2 Adrenergic Receptors, John R. Mantsch, Andy Meyer, Oliver Vranjkovic, Chad E. Beyer, David A. Baker, Holly Caretta Jul 2010

Involvement Of Noradrenergic Neurotransmission In The Stress- But Not Cocaine-Induced Reinstatement Of Extinguished Cocaine-Induced Conditioned Place Preference In Mice: Role For Β-2 Adrenergic Receptors, John R. Mantsch, Andy Meyer, Oliver Vranjkovic, Chad E. Beyer, David A. Baker, Holly Caretta

Biomedical Sciences Faculty Research and Publications

The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse. This study investigated the role of noradrenergic systems in the reinstatement of extinguished cocaine-induced conditioned place preference by cocaine and stress in male C57BL/6 mice. Cocaine- (15 mg/kg, i.p.) induced conditioned place preference was extinguished by repeated exposure to the apparatus in the absence of drug and reestablished by a cocaine challenge (15 mg/kg), exposure to a stressor (6-min forced swim (FS); 20–25°C water), or administration of the α-2 adrenergic receptor (AR) antagonists yohimbine …


Hypertension In Children And Adolescents: Epidemiology And Natural History., Bonita Falkner Jul 2010

Hypertension In Children And Adolescents: Epidemiology And Natural History., Bonita Falkner

Department of Medicine Faculty Papers

Primary hypertension is detectable in children and adolescents and, as in adults, is associated with a positive family history of hypertension, obesity, and life-style factors. Owing to the well-established childhood obesity epidemic, the population prevalence of high blood pressure (BP) in the young is increasing. Hypertension in childhood is commonly associated with other cardiovascular risk factors as well as obesity. Although death and cardiovascular disability do not occur in hypertensive children, intermediate markers of target organ damage, such as left ventricular hypertrophy, thickening of the carotid vessel wall, retinal vascular changes, and even subtle cognitive changes, are detectable in children …


Nipple Adenoma Of Breast: A Masquerader Of Malignancy, Kanwal Aftab, Romana Idress Jul 2010

Nipple Adenoma Of Breast: A Masquerader Of Malignancy, Kanwal Aftab, Romana Idress

Department of Pathology and Laboratory Medicine

Nipple adenoma is a benign condition simulating malignancy such as breast carcinoma and/or Paget’s disease clinically. In this study 19 cases diagnosed as nipple adenoma over a period of 14 years are described. The diagnosis was confirmed by histology alone. All patients were females with age ranging from 23 to 63 years. Most of the cases presented clinically with in duration and ulceration accompanied by pain and itching. The diagnosis was clinically suspected in only 3 cases. This highlights the importance of histological diagnosis in all suspicious breast lesions. In one case, the clinical and histological diagnosis was incorrect leading …


Gsk-3alpha Directly Regulates Beta-Adrenergic Signaling And The Response Of The Heart To Hemodynamic Stress In Mice., Jibin Zhou, Hind Lal, Xiongwen Chen, Xiying Shang, Jianliang Song, Yingxin Li, Risto Kerkela, Bradley W Doble, Katrina Macaulay, Morgan Decaul, Walter J Koch, John Farber, James Woodgett, Erhe Gao, Thomas Force Jul 2010

Gsk-3alpha Directly Regulates Beta-Adrenergic Signaling And The Response Of The Heart To Hemodynamic Stress In Mice., Jibin Zhou, Hind Lal, Xiongwen Chen, Xiying Shang, Jianliang Song, Yingxin Li, Risto Kerkela, Bradley W Doble, Katrina Macaulay, Morgan Decaul, Walter J Koch, John Farber, James Woodgett, Erhe Gao, Thomas Force

Center for Translational Medicine Faculty Papers

The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases consists of 2 highly related isoforms, alpha and beta. Although GSK-3beta has an important role in cardiac development, much remains unknown about the function of either GSK-3 isoform in the postnatal heart. Herein, we present what we believe to be the first studies defining the role of GSK-3alpha in the mouse heart using gene targeting. Gsk3a(-/-) mice over 2 months of age developed progressive cardiomyocyte and cardiac hypertrophy and contractile dysfunction. Following thoracic aortic constriction in young mice, we observed enhanced hypertrophy that rapidly transitioned to ventricular dilatation and contractile dysfunction. …


Soft Tissue Profile Response In Extraction Versus Non-Extraction Orthodontic Treatment, Munizeh Khan, Mubassar Fida Jul 2010

Soft Tissue Profile Response In Extraction Versus Non-Extraction Orthodontic Treatment, Munizeh Khan, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

Objective: To compare changes occurring in the soft tissue profile with orthodontic treatment in extraction versus nonextraction cases, and to determine the hard and soft tissue parameters that show significant correlations to understand the factors influencing the response to tooth movement. Study Design: Quasi-experimental. Place and Duration of Study: Dental Section, The Aga Khan University Hospital, Karachi, from 2005 to 2008. Methodology: Pre- and post-treatment lateral cephalographs of 34 subjects were assessed. For half of the patients (n=17), treatment included the extraction of 4 premolars, whereas the other half were treated by the non-extraction approach. Incisal and soft tissue effects …


Review Of: Culture In Rehabilitation From Competency To Proficiency, Robin D. Washington Jul 2010

Review Of: Culture In Rehabilitation From Competency To Proficiency, Robin D. Washington

Internet Journal of Allied Health Sciences and Practice

Culture in Rehabilitation from Competency to Proficiency provides pertinent information geared specifically towards health care professionals, educators, and students working in various settings with a culturally diverse population of patients and clients. The textbook is also applicable for all individuals interested in a general perspective of culture and ethnicity as related to health care issues. Contributors of this book represent a variety of healthcare professions that include occupational therapy, physical therapy, speech therapy, nursing, psychology, and pharmacy.


Updating The Dermatologic Nomenclature: Names That Are Good Or Bad., Lawrence Charles Parish, Joseph A. Witkowski Jul 2010

Updating The Dermatologic Nomenclature: Names That Are Good Or Bad., Lawrence Charles Parish, Joseph A. Witkowski

Department of Dermatology and Cutaneous Biology Faculty Papers

Dermatology probably has the largest vocabulary of any of the medical specialties,1 a statement to which we can attest when we reviewed aspects of the Dermatology Lexicon project. Some terms are derived from the Latin or Greek and present spelling problems to all but a select few. Examples include acrokeratosis verruciformis and pterigium. Other diseases carry names that are such a mouthful that few can call them out without the interruption of breathing. These might include erosio interdigitalis blastomycetica and dermatitis exudative discoid and lichenoid of Sulzberger and Garbe. No wonder the former is now referred to simply as …


A Parasitological Paradox: Why Is Ascarid Infection So Rare In The Prehistoric Americas?, Daniela Leles, Karl Reinhard, Martín Horacio Fugassa, Luis Fernando Ferreira, Alena M. Iñiguez, Adauto Araujo Jul 2010

A Parasitological Paradox: Why Is Ascarid Infection So Rare In The Prehistoric Americas?, Daniela Leles, Karl Reinhard, Martín Horacio Fugassa, Luis Fernando Ferreira, Alena M. Iñiguez, Adauto Araujo

Karl Reinhard Publications

Ascaris lumbricoides (giant roundworm) and Trichuris trichiura (whipworm) are the most common intestinal parasites found in humans worldwide today and they almost always co-occur. However, we find two distinct patterns in archae­ological material. In historical North American and Old World contexts, the association of A. lumbricoides and T. trich­iura is similar to the modern epidemiological picture. In contrast, the co-occurrence of A. lumbricoides and T. trichiura eggs in prehistoric South America is rare. For prehistoric contexts, T. trichiura is the most common parasite found in ar­chaeological material. Recently molecular biology techniques pointed to a subdiagnosis of roundworm infection in pre- …


Sequelae Of Childhood Sexual Abuse And Chronic Headache Pain In Women, Kathy L. Theiss Jul 2010

Sequelae Of Childhood Sexual Abuse And Chronic Headache Pain In Women, Kathy L. Theiss

Theses and Dissertations - UTB/UTPA

For many years the association of headache with CSA has been postulated and results have been similar across studies indicating a robust connection. Chronic headache is one of the most common causes of visits to physicians and contributes to decreased quality of life for those who suffer with them. Although CSA is detrimental to both men and women, evidence supports that women are more likely to suffer from chronic somatic headache pain than men. Therefore, it is hypothesized that chronic headache is significantly more common among women with a history of childhood sexual abuse when compared to women who have …


Probiotics Are Food; Herbs Are Plants; What’S The Risk? Informed Consent For Complementary And Integrative Therapies, Lisa Hanson, Leona Vandevusse Jul 2010

Probiotics Are Food; Herbs Are Plants; What’S The Risk? Informed Consent For Complementary And Integrative Therapies, Lisa Hanson, Leona Vandevusse

College of Nursing Faculty Research and Publications

No abstract provided.


Adolescents' Preferences For Primary Care Provider Interactions, Kristine C. Schaeuble, Kristin Haglund, Melissa Vukovich Jul 2010

Adolescents' Preferences For Primary Care Provider Interactions, Kristine C. Schaeuble, Kristin Haglund, Melissa Vukovich

College of Nursing Faculty Research and Publications

PURPOSE. Adolescents receive less primary care than other age groups. One reason may be the negative ways that providers sometimes interact with adolescents. The purpose was to develop knowledge regarding adolescents' preferences for provider interactions.

DESIGN AND METHODS. Design was descriptive and mixed method. Donabedian's healthcare quality model guided the study. Data were collected via focus groups and a survey.

RESULTS. Twenty-four adolescents participated. Four themes described their preferences: forming a relationship, supporting independence, assuring confidentiality, and conveying caring.

PRACTICE IMPLICATIONS. Care that is congruent with adolescents' preferences may improve quality of, and access to, care and, ultimately, …