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Articles 1351 - 1380 of 5702
Full-Text Articles in Medicine and Health Sciences
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To Noonan Regarding: Answer To Noonan’S Request For The Prescription For Beaumont’S Most Successful Cholera Treatment For The Use By Noonan And Doctors Wolcott And Dousman. 1849
1849 - 1850
No abstract provided.
Investigation And Optimization Of A Solvent / Anti-Solvent Crystallization Process For The Production Of Inhalation Particles, Swati Agrawal
Investigation And Optimization Of A Solvent / Anti-Solvent Crystallization Process For The Production Of Inhalation Particles, Swati Agrawal
Theses and Dissertations
Dry powder inhalers (DPIs) are commonly used to deliver drugs to the lungs. The drug particles used in these DPIs should possess a number of key properties. These include an aerodynamic particle size < 5μm and particle crystallinity for long term formulation stability. The conventionally used micronization technique to produce inhalation particles offers limited opportunities to control and optimize the particle characteristics. It is also known to induce crystalline disorder in the particles leading to formulation instability. Hence, this research project investigates and optimizes a solvent/anti-solvent crystallization process capable of directly yielding inhalation particles using albuterol sulfate (AS) as a model drug. Further, the feasibility of the process to produce combination particles of AS and ipratropium bromide monohydrate (IB) in predictable proportions and in a size suitable for inhalation is also investigated. The solvent / anti-solvent systems employed were water / ethyl acetate (EA) and water / isopropanol (IPA). Investigation and optimization of the crystallization variables with the water / EA system revealed that particle crystallinity was significantly influenced by an interaction between the drug solution / anti-solvent ratio (Ra ratio), stirring speed and crystal maturation time. Inducing a temperature difference between the drug solution and anti-solvent (Tdrug solution > Tanti-solvent) resulted in smaller particles being formed at a positive temperature difference of 65°C. IPA was shown to be the optimum anti-solvent for producing AS particles (IPA-AS) in a size range suitable for inhalation. In vitro aerosol performance of these IPA-AS particles was found to be superior compared to the conventionally used micronized particles when aerosolized from the Novolizer®. The solvent / anti-solvent systems investigated and optimized …
Poxa, Yjek And Elongation Factor P Coordinately Modulate Virulence And Drug Resistance In Salmonella Enterica, William Wiley Navarre, Shicong Zou, Hervé Roy, Jinglin Lucy Xie, Alexei Savchenko, Alexander Singer, Elena Edvokimova, Lynne R. Prost, Runjun Kumar, Michael Ibba, Ferric C. Fang
Poxa, Yjek And Elongation Factor P Coordinately Modulate Virulence And Drug Resistance In Salmonella Enterica, William Wiley Navarre, Shicong Zou, Hervé Roy, Jinglin Lucy Xie, Alexei Savchenko, Alexander Singer, Elena Edvokimova, Lynne R. Prost, Runjun Kumar, Michael Ibba, Ferric C. Fang
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-β-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, including attenuated virulence in mice, an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered expression of multiple proteins, including several encoded on the SPI-1 pathogenicity island. PoxA mediates posttranslational modification of bacterial elongation factor P (EF-P), analogous to the modification of the eukaryotic EF-P homolog, eIF5A, with …
The Impact Of Adolescent Nicotine Exposure On Drug Dependence In Adulthood, Mai Alajaji
The Impact Of Adolescent Nicotine Exposure On Drug Dependence In Adulthood, Mai Alajaji
Theses and Dissertations
Nicotine is one of the first and most commonly abused drugs in adolescence. According to The Center for Disease Control, every day more than 6000 adolescents try their first cigarette and over 3000 of them become daily smokers. Smoking among adolescents is a strong predictor of future drug abuse and dependence in adulthood. A number of studies has suggests that adolescents pre-exposed to nicotine may suffer permanent disruption of the brain’s reward systems through changes in dopamine receptor function. We hypothesize that nicotine exposure during adolescence causes long lasting neurobiological alterations that increase the likelihood of cocaine use in adulthood. …
J.H. (John Henry) Freligh, Steamer Prairie [New Orleans, La] To W. Beaumont [Saint Louis, Mo] Regarding: Requests Renewal Of Freligh’S Note Due At The Bank Of Missouri, News Of Heavy Ice On Journey To New Orleans And Not Enough Freight At Port For Return. January 26, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To George Johnson, Jr. Regarding: Names T. Polk And Captain Kingsbury As His Referees In Settlement Of Accounts With George Johnson. March 15, 1849
1849 - 1850
No abstract provided.
George Johnson Jr. [Saint Louis, Mo] To W. Beaumont Regarding: Request For Beaumont To Name Referee In Settlement Of Accounts With George Johnson. March 14, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To George Johnson, Jr. Regarding: Settlement Of Accounts With George Johnson. March 16, 1849
1849 - 1850
No abstract provided.
George Johnson, Jr. [Saint Louis, Mo] To W. Beaumont, Regarding: Names Of Referees In Settlement Of Accounts With Beaumont. March 15, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To George Johnson, Jr. Regarding: Meeting Place And Date Suggested In Settlement Of Accounts With George Johnson. March 17, 1849
1849 - 1850
No abstract provided.
George Johnson, Jr. [Saint Louis, Mo] To W. Beaumont, Regarding: Referee Agreed Upon In Settlement Of Accounts With George Johnson. March 16, 1849
1849 - 1850
No abstract provided.
Robert Mcpherson [Buffalo, Ny] To W. Beaumont [Saint Louis, Mo] Regarding: Request For Payment. March 20, 1849. W. Beaumont [Saint Louis, Mo] To Robert Mcpherson Regarding: Payment Of Note Held By Mcpherson. May 1, 1849
1849 - 1850
No abstract provided.
George Johnson, Jr. [Saint Louis, Mo] To W. Beaumont Regarding: Date Changed In Settlement Of Accounts With George Johnson. March 20, 1849
1849 - 1850
No abstract provided.
Memorandum By W. Beaumont [Saint Louis, Mo] Regarding: Relationship Between Him And Johnson Including Enlistment Of Johnson With Commencement Of Studies In 1841, No Partnership Formed But Relationship One Of Merchant To Clerk, Salary Allotted George Johnson, Room And Board Given. March 19, 1849
1849 - 1850
No abstract provided.
George Johnson, Jr. [Saint Louis, Mo] To W. Beaumont Regarding: Settlement Of Accounts With George Johnson. March 24, 1849
1849 - 1850
No abstract provided.
George Johnson, Jr. [Saint Louis, Mo] To W. Beaumont Regarding: Referees Disagree And Refuse To Accept Umpire In Settlement Of Accounts, Settlement For A Sum Proposed To Johnson Or New Referees Named, Answer Requested In 24 Hours By Johnson. March 22, 1849
1849 - 1850
No abstract provided.
Morgan L. Martin [Green Bay, Wi] To W. Beaumont [Saint Louis, Mo] Regarding: Land Title Dispute In Green Bay With Heirs Of Stoddard By Indian Woman. September 10, 1849
1849 - 1850
No abstract provided.
Robert Mcpherson [Buffalo, Ny] To W. Beaumont [Saint Louis, Mo] Regarding: Second Request For Payment. May 8, 1849. W. Beaumont [Saint Louis, Mo] To Robert Mcpherson [Buffalo, Ny] Regarding: Reply To Request For Payment. May 21, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To Thomas Green And M.L. Martin Regarding: Adjustments To Title For Green Bay Land, Title In Dispute. September 29, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To M. L. Martin [Green Bay, Wi] Regarding: Compromise On Title Dispute In Green Bay. September 30, 1849
1849 - 1850
No abstract provided.
Thomas Green [Green Bay, Wi] To W. Beaumont [Saint Louis, Mo] Regarding: News From Green Bay, Compromise On Land Title Dispute For Green Bay Property. October 23, 1849
1849 - 1850
No abstract provided.
Memorandum From W. Beaumont [Saint Louis, Mo] To George Johnson, Jr. Regarding: Settlement Of Accounts With Johnson, Rent To Be Paid For Use Of Beaumont’S Office. November 1, 1849. Memorandum From George Johnson Jr. Regarding: List Of Names And Amounts Paid In Cash From January 2, 1844 Through November 27, 1847 With Interest He Assigned. March 27, 1849. Memorandum From George Johnson, Jr. Regarding: Duplicate Receipt Of $1500 Paid To Johnson By Beaumont And List Of Johnson’S Uncollected Accounts To January 1, 1848. March 27, 1849. Memorandum From George Johnson, Jr. Regarding: Memo Of Old Unsettled Balances On Books Through January 1, 1850 And List Of Names With Money Owed Beaumont. January 1, 1850
1849 - 1850
No abstract provided.
J. S. (Joel S.) Fisk [Green Bay, Wi] To W. Beaumont [Saint Louis, Mo] Regarding: Price Of Land Requested By Fisk. November 23, 1849
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To William Morrison [Berthier, Canada] Regarding: Another Attempt To Employ St. Martin Through Morrison. January 31, 1850
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To W.G. Edwards [Paris, France] Regarding: News Of St. Martin’S Health And Large Family, His Residence In Canada, Thwarted Attempts To Do More Experiments Since 1834. January 31, 1850
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To William Morrison [Berthier, Canada] Regarding: Attempt To Employ St. Martin Through Morrison, Monies To Be Sent St. Martin Through Morrison, St. Martin And Family To Be Given House By Beaumont, Doubt About St. Martin’S Sincerity. May 4, 1850
1849 - 1850
No abstract provided.
William Morrison [Berthier, Canada] To W. Beaumont [Saint Louis, Mo] Regarding: St. Martin And Family Ready To Travel, Monies Requested By St. Martin, St. Martin Described As A Reformed Man, St. Martin And Family To Be Employed By Beaumont For 1 Year And Given Board And Travel Expenses. February 23, 1850
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To St. Martin Regarding: Request To Honor Obligations. May 4, 1850
1849 - 1850
No abstract provided.
William Morrison [Berthier, Canada] To W. Beaumont [Saint Louis, Mo] Regarding: St. Martin Ready To Travel With Family, Request By St. Martin For Advance For Travelling Expenses. June 24, 1850
1849 - 1850
No abstract provided.
Draft Of Letter From W. Beaumont [Saint Louis, Mo] To William Morrison, Regarding: St. Martin’S Traveling Expenses, Contract To Be Settled After St. Martin Arrives, Advice Given About St. Martin’S Route To Saint Louis, Cautions Against Misuse Of Advance By St. Martin. August 4, 1850
1849 - 1850
No abstract provided.