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Articles 1261 - 1290 of 5702
Full-Text Articles in Medicine and Health Sciences
Perceived Levels Of Nurse Educators' Attainment Of Nln Core Competencies, Julie Kinney Higbie
Perceived Levels Of Nurse Educators' Attainment Of Nln Core Competencies, Julie Kinney Higbie
Dissertations
Nurse educators need to be well-prepared with essential competencies, to prepare nurses for their future in health care. Nurses who are recruited to teach, must meet at least minimal competencies and be provided appropriate resources to assume their roles in academia. The recently published National League for Nursing (NLN) Core Competencies for Nurse Educators (2005) identify the skills, knowledge and attitudes necessary for both novice and experienced faculty.
This research study explored faculty's perceived attainment of these competencies utilizing Benner's Novice to Expert theory as a framework. It examined several areas of interest related to nurse educator competency, years of …
Single Lung Ventilation In A Young Child For Repair Of Coarctation Of Aorta, Mohammad Hamid, Mansoor Ahmed Khan, Muneer Amanullah
Single Lung Ventilation In A Young Child For Repair Of Coarctation Of Aorta, Mohammad Hamid, Mansoor Ahmed Khan, Muneer Amanullah
Department of Anaesthesia
Single lung ventilation in small children is extremely challenging. In this case, a paediatric bronchial blocker was successfully inserted in a 19-month-old child to provide single lung ventilation using a modified insertion technique. It provided excellent working conditions during thoracotomy and our method of insertion may help in reducing the cost.
An Analytic Hierarchy Process Approach To Assess Health Service Quality, Yan Li
An Analytic Hierarchy Process Approach To Assess Health Service Quality, Yan Li
Theses and Dissertations - UTB/UTPA
While improving quality in health care is currently at the forefront of professional, political, and managerial attention, the key dimensions constituting health-care quality have not been fully understood. Also, few valid approaches have been proposed to the measurement of health-care quality. In this research, the Analytic Hierarchy Process (AHP) approach is applied to study the structure of health-care quality and deducted relative importance weights for each of the quality elements. A statistical quality model is derived to assess medical equipment quality which is an important part constituting the general health-care quality. Finally, the application of the AHP model to assess …
Spontaneous Disconnection Of Glaucoma Tube Shunt Extenders., Oseluese Dawodu, Alex V. Levin
Spontaneous Disconnection Of Glaucoma Tube Shunt Extenders., Oseluese Dawodu, Alex V. Levin
Wills Eye Hospital Papers
Glaucoma drainage implants are frequently used in children with severe forms of glaucoma, and tube extenders are sometimes required to compensate for ocular growth or when the intraocular portion of the tube is thought to be too short. We report 2 cases of spontaneous disconnection of a tube extender, occurring 8 months after insertion in one case and 3 years later in the other. In both cases the tube was removed and the patient treated with endoscopic diode laser photocoagulation.
The Challenge Of Head & Neck Squamous Cell Carcinoma Control In Pakistan, Syed Mohammad Asad Zaidi, Nauman Fazal Manzoor, Shabbir Akhtar
The Challenge Of Head & Neck Squamous Cell Carcinoma Control In Pakistan, Syed Mohammad Asad Zaidi, Nauman Fazal Manzoor, Shabbir Akhtar
Section of Otolaryngology, Head & Neck Surgery
No abstract provided.
Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan
Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan
Section of Gastroenterology
Studies have suggested a possible role for Blastocystis hominis and Dientamoeba fragilis in the etiology of irritable bowel syndrome (IBS). We studied the prevalence of B. hominis and D. fragilis in patients with IBS-diarrhea (IBS-D). Three hundred and thirty patients were enrolled, 171 (52%) with IBS-D and 159 (48%) were controls, respectively. Stool microscopy, culture, and polymerase chain reaction (PCR) for B. hominis and D. fragilis were done. B. hominis was positive by stool microscopy in 49% (83/171) of IBS compared to 24% (27/159) in control (p < 0.001). B. hominis culture was positive in 53% (90/171) in IBS compared to 16% (25/159) in control (p < 0.001). B. hominis PCR was positive in 44% (75/171) in IBS compared to 21% (33/159) in control (p < 0.001). D. fragilis microscopy was positive in 3.5% (6/171) in IBS-D compared to 0.6% (1/159) in control (p = 0.123). D. fragilis culture was positive in 4% (7/171) in IBS compared to 1.3% (2/159) in control (p = 0.176). D. fragilis PCR was positive in 4% (6/171) in IBS-D compared to 0% (0/159) in control (p = 0.030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR.
Relationships Among Person And Environment Variables And Turnover Intention In Adults With Multiple Sclerosis, Wanda Shull
Relationships Among Person And Environment Variables And Turnover Intention In Adults With Multiple Sclerosis, Wanda Shull
Graduate Theses and Dissertations
The organization and management literature presents a large base of research on the concept of turnover intention, i.e. the point at which a person decides to leave employment. What is known is that turnover intention is the precursor to employee turnover, yet very little research exists in the rehabilitation field to address this concept in terms of persons with chronic illness and disability. This study examines this variable in the population of adults with multiple sclerosis (MS). Employing multivariate analysis of variance (MANOVA) to analyze three blocks of variables and their impact on turnover intention, the results show that groups …
Asian Race/Ethnicity As A Risk Factor For Bile Duct Injury During Cholecystectomy., Stephanie R. Downing, Ghazala Datoo, Tolulope A. Oyetunji, Terrence Fullum, David C. Chang, Nita Ahuja
Asian Race/Ethnicity As A Risk Factor For Bile Duct Injury During Cholecystectomy., Stephanie R. Downing, Ghazala Datoo, Tolulope A. Oyetunji, Terrence Fullum, David C. Chang, Nita Ahuja
Manuscripts, Articles, Book Chapters and Other Papers
Iatrogenic bile duct injury (BDI) is an uncommon but serious complication of cholecystectomy, with identified risk factors of acute cholecystitis, male sex, older age, and aberrant biliary anatomy. The Nationwide Inpatient Sample (1998-2006) was queried for cholecystectomy performed on hospital day 0 or 1. Bile duct injury repair procedure codes were used as a surrogate for BDI. We identified 377,424 patients who underwent cholecystectomy, with 1124 BDIs (0.3%). On multivariate logistic regression analysis, Asian race/ethnicity was a significant risk factor for BDI (odds ratio [OR], 2.26; 95% confidence interval [CI], 1.59-3.23; P < .001). This persisted for laparoscopic (OR, 2.62; 95% CI, 1.28-5.39; P = .009) and open (2.21; 1.59-3.07; P < .001) cholecystectomies. No other race/ethnicity was identified as a risk factor for BDI. We report a new finding that Asian race/ethnicity is a significant risk factor for BDI in laparoscopic and open cholecystectomies.
Distribution Of Left Ventricular Ejection Fraction In Angina Patients With Severe Coronary Artery Disease Not Amenable To Revascularization., Shuchita Gupta, Gregg S. Pressman, D Lynn Morris, Vincent M. Figueredo, M.D.
Distribution Of Left Ventricular Ejection Fraction In Angina Patients With Severe Coronary Artery Disease Not Amenable To Revascularization., Shuchita Gupta, Gregg S. Pressman, D Lynn Morris, Vincent M. Figueredo, M.D.
Division of Cardiology Faculty Papers
BACKGROUND: As the number of angina patients with severe coronary artery disease not amenable to revascularization increases, new therapies will be developed. How patients with depressed compared to normal left ventricular ejection fraction (LVEF) will respond to new therapies may differ.
HYPOTHESIS: We conducted a retrospective chart review to determine the distribution of LVEF in angina patients with severe coronary artery disease (three-vessel disease with >50% stenosis major epicardial vessels or >50% stenosis left main) not amenable to revascularization.
METHODS: Patients underwent cardiac catheterization between 2004 and 2009. LVEF, measured by echocardiography, nuclear-gated imaging or radioventriculography within 6 months of …
Regulation Of Morphogenesis In Filamentous Fungi, Haoyu Si
Regulation Of Morphogenesis In Filamentous Fungi, Haoyu Si
School of Biological Sciences: Dissertations, Theses, and Student Research
One of the distinguishing features of fungal cells is their highly polarized model of growth. Both yeast cells and hyphal cells grow by cell surface expansion at specified cortical sites. Although the same general mechanisms are likely to be involved in controlling the establishment of hyphal polarity in budding yeast and filamentous fungi, it is noticeable that hyphal cells are organized in a fundamentally different manner to yeast dells. For example, hyphal cells organize formins, septins and actins at the division site while simultaneously retain the same machinery at the tip; whereas yeast cells undergo a transient period of isotropic …
Perceived Stigma Among Patients Receiving Antiretroviral Treatment: A Prospective Randomised Trial Comparing An M-Dot Strategy With Standard-Of-Care In Kenya, Susan Kaai, Sandra Bullock, Avina Sarna, Matthew Chersich, Stanley Luchters, Scott Geibel, Kishorchandra Mandaliya, Marleen Temmerman, Naomi Rutenberg
Perceived Stigma Among Patients Receiving Antiretroviral Treatment: A Prospective Randomised Trial Comparing An M-Dot Strategy With Standard-Of-Care In Kenya, Susan Kaai, Sandra Bullock, Avina Sarna, Matthew Chersich, Stanley Luchters, Scott Geibel, Kishorchandra Mandaliya, Marleen Temmerman, Naomi Rutenberg
Population Health, East Africa
HIV and AIDS remain highly stigmatised. Modified directly observed therapy (m-DOT) supports antiretroviral treatment (ART) adherence but little is known about its association with perceived stigma in resource-constrained settings. In 2003, 234 HIV-infected adults enrolled in a two-arm randomised trial comparing a health centre-based m-DOT strategy with standard self-administration of ART. Data on perceived stigma were collected using Berger's HIV stigma scale prior to starting ART and after 12 months. This was a secondary analysis to examine whether perceived stigma was related to treatment delivery. Perceived stigma scores declined after 12 months of treatment from a mean of 44.9 (sd=7.6) …
The Influence Of Perspective And Gender On The Processing Of Narratives, Jeremy A. Houska
The Influence Of Perspective And Gender On The Processing Of Narratives, Jeremy A. Houska
UNLV Theses, Dissertations, Professional Papers, and Capstones
The overarching aim of this research was to examine potential boundary conditions to situation model construction (Experiment 1) and narrative-based persuasion (Experiment 3). Variables such as narrative perspective (i.e., 2nd or 3rd person) and matched characteristics with the reader (i.e., participant-protagonist gender match) were first examined using situation model updating (Experiment 1) and behavioral measures (Experiment 3) as dependent measures. It was expected that situation model updating would be more likely for narratives written in the 2nd person perspective and with a participant-protagonist gender match. It was uncertain, however, for health promotion narratives, whether these manipulations would increase the likelihood …
Neutron Flux And Energy Characterization Of A Plutonium-Beryllium Isotopic Neutron Source By Monte Carlo Simulation With Verification By Neutron Activation Analysis, Zachary R. Harvey
Neutron Flux And Energy Characterization Of A Plutonium-Beryllium Isotopic Neutron Source By Monte Carlo Simulation With Verification By Neutron Activation Analysis, Zachary R. Harvey
UNLV Theses, Dissertations, Professional Papers, and Capstones
The purpose of this research was to characterize the neutron energy distribution and flux emitted from the UNLV plutonium-beryllium source, serial number MRC-N-W PuBe 453. This was accomplished through the use of the MCNPX/5 Monte-Carlo particle transport code to simulate radiation interactions within the physical environment of the source and its surroundings. The moderating drum currently containing the source as well as all of the sampling ports were accurately modeled in MCNPX/5. This geometry was then used to simulate the neutron interactions taking place in these geometries. The results of the simulations were then verified by the use of specifically …
Immunohistochemical Mapping Of Hypoxia In Ischemic Mouse Hindlimb Skeletal Muscle, Emily Deckert
Immunohistochemical Mapping Of Hypoxia In Ischemic Mouse Hindlimb Skeletal Muscle, Emily Deckert
Biomedical Engineering
The study of blood vessel growth and remodeling is a complex endeavor. Hypoxia, the lack of oxygen in a tissue, is known to stimulate angiogenesis (the growth of new blood vessels), and have little effect on arteriogenesis (the enlargement of existing blood vessels). However, the role of hypoxia in vessel function is unknown, but may be determined using the results and methods developed in this experiment.
Supplied by the bloodstream, oxygen is required by all cells and tissues to remain healthy. If the bloodstream supplying a certain tissue with blood is disrupted, the tissue becomes ischemic, often leading to hypoxia. …
Brain Candy: Wayne State University School Of Medicine Journal Of Art And Literature, 2nd Edition, Wayne State University School Of Medicine Writing Workshop, Wayne State University School Of Medicine Gold Humanism Honor Society
Brain Candy: Wayne State University School Of Medicine Journal Of Art And Literature, 2nd Edition, Wayne State University School Of Medicine Writing Workshop, Wayne State University School Of Medicine Gold Humanism Honor Society
Gold Humanism Honor Society
The second edition of Brain Candy collects poetry, nonfiction essays, short fiction, photographs, and drawings to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. Features submissions from medical students, physicians, and School of Medicine staff, faculty and staff from Wayne State's departments of Art, English, and Pharmacy. We have also included a section of work by some of Detroit's youngest aspiring doctors.
How Should Physicians Practically Approach Symptomatic And Asymptomatic Carotid Stenosis?, Maria Khan, Ayeesha Kamran Kamal
How Should Physicians Practically Approach Symptomatic And Asymptomatic Carotid Stenosis?, Maria Khan, Ayeesha Kamran Kamal
Section of Neurology
No abstract provided.
Ecology: A Prerequisite For Malaria Elimination And Eradication, Heather M. Ferguson, Anna Dornhaus, Arlyne Beeche, Christian Borgemeister, Michael Gottlieb, Mir S. Mulla, John E. Gimnig, Durland Fish, Gerry F. Killeen
Ecology: A Prerequisite For Malaria Elimination And Eradication, Heather M. Ferguson, Anna Dornhaus, Arlyne Beeche, Christian Borgemeister, Michael Gottlieb, Mir S. Mulla, John E. Gimnig, Durland Fish, Gerry F. Killeen
All Peer-Reviewed Publications
Existing front-line vector control measures, such as insecticide-treated nets and residual sprays, cannot break the transmission cycle of Plasmodium falciparum in the most intensely endemic parts of Africa and the Pacific. The goal of malaria eradication will require urgent strategic investment into understanding the ecology and evolution of the mosquito vectors that transmit malaria. Priority areas will include understanding aspects of the mosquito life cycle beyond the blood feeding processes which directly mediate malaria transmission. Global commitment to malaria eradication necessitates a corresponding longterm commitment to vector ecology.
Landmarks In The Evolution Of Technologies For Identifying Trypanosomes In Tsetse Flies, John C. Enyaru, Johnson O. Ouma, Imna I. Malele, Enock Matovu, Daniel K. Masiga
Landmarks In The Evolution Of Technologies For Identifying Trypanosomes In Tsetse Flies, John C. Enyaru, Johnson O. Ouma, Imna I. Malele, Enock Matovu, Daniel K. Masiga
All Peer-Reviewed Publications
Understanding what the trypanosome pathogens are, their vectors and mode of transmission underpin efforts to control the disease they cause in both humans and livestock. The risk of transmission is estimated by determining what proportion of the vector population is carrying the infectious pathogens. This risk also depends on the infectivity of the trypanosomes to humans and livestock. Most livestock pathogens are not infective to humans, whereas the two sub-species that infect humans also infect livestock. As with other infectious diseases, we can therefore trace the foundation of many continuing disease control programs for trypanosomiasis to the discovery of the …
The Bi-Objective Master Physician Scheduling Problem, Aldy Gunawan, Hoong Chuin Lau
The Bi-Objective Master Physician Scheduling Problem, Aldy Gunawan, Hoong Chuin Lau
Research Collection School Of Computing and Information Systems
Physician scheduling is the assignment of physicians to perform different duties in the hospital timetable. In this paper, the goals are to satisfy as many physicians’ preferences and duty requirements as possible while ensuring optimum usage of available resources. We present a mathematical programming model to represent the problem as a bi-objective optimization problem. Three different methods based on ε–Constraint Method, Weighted-Sum Method and HillClimbing algorithm are proposed. These methods were tested on a real case from the Surgery Department of a large local government hospital, as well as on randomly generated problem instances. The strengths and weaknesses of the …
How Should Physicians Practically Approach Symptomatic And Asymptomatic Carotid Stenosis?, Maria Khan, Ayeesha Kamran Kamal
How Should Physicians Practically Approach Symptomatic And Asymptomatic Carotid Stenosis?, Maria Khan, Ayeesha Kamran Kamal
Department of Medicine
No abstract provided.
A Systematic Review Of Dental Disease In Patients Undergoing Cancer Therapy, Catherine H.L. Hong, Joel J. Napeñas, Brian D. Hodgson, Monique A. Stokman, Vickie Mathers-Stauffer, Linda S. Elting, Fred K.L. Spijkervet, Michael T. Brennan
A Systematic Review Of Dental Disease In Patients Undergoing Cancer Therapy, Catherine H.L. Hong, Joel J. Napeñas, Brian D. Hodgson, Monique A. Stokman, Vickie Mathers-Stauffer, Linda S. Elting, Fred K.L. Spijkervet, Michael T. Brennan
School of Dentistry Faculty Research and Publications
Introduction: The purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies.
Review Method: A systematic literature search was conducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental …
Web-Based Training Method For Interpretation Of Dental Images, Min Wu, Xiao Zhang, Lisa J. Koenig, John Lynch, Thomas S. Wirtz, En Mao, Lei Ying
Web-Based Training Method For Interpretation Of Dental Images, Min Wu, Xiao Zhang, Lisa J. Koenig, John Lynch, Thomas S. Wirtz, En Mao, Lei Ying
School of Dentistry Faculty Research and Publications
No abstract provided.
Clinical And Mechanical Evaluation Of A New All-Ceramic Restorative Material Turkom-Cera., Bandar Mohammed Abdullah Al-Makramani
Clinical And Mechanical Evaluation Of A New All-Ceramic Restorative Material Turkom-Cera., Bandar Mohammed Abdullah Al-Makramani
Student Works (2010-2019)
The mechanical properties and clinical performance of Turkom-Cera system were evaluated in this study. The mechanical properties evaluated were; flexural strength, microhardness, shear bond strength, fracture resistance and marginal integrity. The biaxial flexural strength and hardness of Turkom-Cera compared to two other allceramic systems (In-Ceram and Vitadur-N) were investigated. The Turkom-Cera exhibited significantly higher flexural strength (506.8 MPa) than In-Ceram (347.4 MPa) and Vitadur-N (128.7 MPa) ceramic materials. However, In-Ceram core has significantly higher hardness (1116.2 VHN) than Turkom-Cera (1002.1 VHN) and Vitadur-N (812.8 VHN) all-ceramic materials. In order to find the optimal choice of luting cement and surface treatment …
Failure Of Intimate Partner Violence Screening Among Patients With Substance Use Disorders, Esther K. Choo, Christina Nicolaidis, Robert H. Jenkinson, Jessi M. Cox, Kenneth J. Mcconnell
Failure Of Intimate Partner Violence Screening Among Patients With Substance Use Disorders, Esther K. Choo, Christina Nicolaidis, Robert H. Jenkinson, Jessi M. Cox, Kenneth J. Mcconnell
School of Social Work Faculty Publications and Presentations
Objectives: This study examined the relationship between substance use disorder (SUD) and intimate partner violence screening (IPV) and management practices in the emergency department (ED). Methods: This was a retrospective cohort study of adult ED patients presenting to an urban, tertiary care teaching hospital over a 4-month period. An automated electronic data abstraction process identified consecutive patients and retrieved visit characteristics, including results of three violence screening questions, demographic data, triage acuity, time of visit, and ICD-9 diagnosis codes. Data on management were collected using a standardized abstraction tool by two reviewers masked to the study question. Multivariate logistic regression …
The Live Experience Of Non-Degree Learners From A Time Modified Traditional Baccalaureate In Nursing Program, Stephanie S. Deboor
The Live Experience Of Non-Degree Learners From A Time Modified Traditional Baccalaureate In Nursing Program, Stephanie S. Deboor
UNLV Theses, Dissertations, Professional Papers, and Capstones
By the year 2016, it is projected that a million new and replacement nurses will be needed throughout the United States. The traditional 4-year baccalaureate program alone cannot adequately sustain this demand. The immediacy of the current nursing shortage demands our educational systems respond by building and maintaining a workforce that is sufficient to support the health care needs of our society. In an attempt to meet this challenge, nursing schools around the country began exploring the option of creating accelerated programs for those who already possess a bachelor's degree in another field without compromising the integrity and quality of …
Tongueless: Representation Of The Mentally Disabled And The Novel, Brent Walter Cline
Tongueless: Representation Of The Mentally Disabled And The Novel, Brent Walter Cline
Dissertations
This study examines the representation of the mentally disabled in the novel for two related outcomes. The first is to prove that the representation of the mentally disabled is not merely a subset of the representation of the disabled in general. This is intended less as a political statement as it is a literary one. Acknowledging and building off the work of writers in disability studies such as David Mitchell, Sharon Snyder, and Tobin Siebers who concentrate on the body of the disabled, this study shows that attempts to represent the mentally disabled are fundamentally different than those who are …
Lgb-Affirmative Therapists' Use Of Developmental Models Of Lgb-Identity In Therapy. A Phenomenological Investigation, Victoria E. Cane
Lgb-Affirmative Therapists' Use Of Developmental Models Of Lgb-Identity In Therapy. A Phenomenological Investigation, Victoria E. Cane
Dissertations
Socially sanctioned hostility toward sexual minority persons continues to be a reality in the United States and worldwide. Therapists working with sexual minorities have responsibility to provide non-pathologizing, affirmative therapy to these clients. A central aspect of affirmative therapy is therapists' recognition and understanding of sexual orientation (SO) identity and developmental models of sexual minority identity have a played a vital role in promoting this understanding. Although such models have been central to the practice and training of affirmative therapy, therapists' applied use of the models has not been empirically investigated. For this phenomenological study, nine affirmative therapists were interviewed …
Hip Power Asymmetry In Older Adult Fallers And Non-Fallers, Lauren Grace Mcdonald
Hip Power Asymmetry In Older Adult Fallers And Non-Fallers, Lauren Grace Mcdonald
Boise State University Theses and Dissertations
The purpose of this study was to determine if a difference exists in hip power asymmetry between community-dwelling older adult fallers and non-fallers. Hypothesis: fallers would be more asymmetrical than non-fallers. Participants: 21 non-fallers (10 females, 11 males) and 18 fallers (14 females, 4 males) over the age of 65 (76.5 ± 6.9yrs). Method: Isokinetic peak torque during flexion, extension, abduction, and adduction at four velocities was recorded as measures of leg power. Asymmetry equaled the percent of power difference between each leg. Data analysis: Differences in age, physical activity, height, weight, and BMI were assessed …
The Elderly Somali Bantu Experience Of American Health Care: The New Way, Cathy Marie Deckys
The Elderly Somali Bantu Experience Of American Health Care: The New Way, Cathy Marie Deckys
Boise State University Theses and Dissertations
A paucity of research exists involving the emic, or insider perspective, of the elderly Somali Bantu as it pertains to their experience of health care. The purpose of this qualitative, descriptive study is to gain insight into the factors that influence the elderly Somali Bantus’ experience of American health care in Boise, Idaho based on their perspective. The elderly Somali Bantu refugee has experienced many changes since their resettlement to the United States from United Nations’ refugee camps in Kenya four to seven years ago. The majority of this population is illiterate and has no native written language. This is …
Macrophages Loaded With Gold Nanoshells For Photothermal Ablation Of Glioma: An In Vitro Model, Amani Riad Makkouk
Macrophages Loaded With Gold Nanoshells For Photothermal Ablation Of Glioma: An In Vitro Model, Amani Riad Makkouk
UNLV Theses, Dissertations, Professional Papers, and Capstones
The current median survival of patients with glioblastoma multiforme (GBM), the most common type of glioma, remains at 14.6 months despite multimodal treatments (surgery, radiotherapy and chemotherapy). This research aims to study the feasibility of photothermal ablation of glioma using gold nanoshells that are heated upon laser irradiation at their resonance wavelength. The novelty of our approach lies in improving nanoshell tumor delivery by loading them in macrophages, which are known to be recruited to gliomas via tumor-released chemoattractive agents. Ferumoxides, superparamagnetic iron oxide (SPIO) nanoparticles, are needed as an additional macrophage load in order to visualize macrophage accumulation in …