Medicine and Health Sciences Commons^™

Spectral Analysis Of Pathological Acoustic Speech Waveforms, Priyanka Medida

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biomedical engineering is the application of engineering principles and techniques to the medical field. The design and problem solving skills of engineering are combined with medical and biological science, which improves medical disorder diagnosis and treatment. The purpose of this study is to develop an automated procedure for detecting excessive jitter in speech signals, which is useful for differentiating normal from pathologic speech. The fundamental motivation for this research is that tools are needed by speech pathologists and laryngologists for use in the early detection and treatment of laryngeal disorders. Acoustical analysis of speech was performed to analyze various features …

Focus Of Attention On Movement Technique Acquisition Of A Pilates Roll-Up, Kristine M. Bragg

UNLV Theses, Dissertations, Professional Papers, and Capstones

Focus of attention manipulation has been shown to have an effect on learning and performance of movement tasks. The purpose of this experiment was to determine whether inducing an external or internal focus of attention while learning a Pilates roll-up had an effect on movement technique acquisition. Movement form, movement time, and distance reached served as dependent variables. Participants (n=22) were assigned to either an external or internal focus group and verbally instructed through 2 sets of 6 repetitions of the roll-up per day over two practice days. A retention test on Day 3 consisting of 2 sets of 6 …

The Effectiveness And Adoption Of Market-Based State Health Care Expansion Programs, Nathan Gregory Myers

UNLV Theses, Dissertations, Professional Papers, and Capstones

Market-based state health expansion programs are alternatives to government programs like Medicaid and SCHIP which also seek to expand access to health insurance for uninsured populations. These programs either utilize the private health insurance market or function according to market principles. The market-based policies at issue in this research are state high-risk health insurance pools, limited benefit plans, group purchasing arrangements, reinsurance programs, and Health Insurance Flexibility and Accountability waivers. This research addresses two separate but related research questions: (1) Do these market-based programs provide general economic and social benefits for the citizens of a state? (2) What role does …

Disease In The Desert: Las Vegas As A Case Study Of How First Responders And Emergency Managers Understand Novel Threats To Human Health And Plan To Respond During Biological Emergencies, Monique Williamson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Over recent years it has become clear that technological advancements, globalization, and ecological change, combined with the onset of increased terrorist incidents, are all currently working to create an extremely hazardous environment in terms of pathogenic invasion. Realizing that infectious diseases are both newly emerging and re-emerging in many parts of the world, the question of how prepared an expansive United States will be in the face of an oncoming global pandemic is easily raised. Using Las Vegas as an example of just how unequipped a largely visited U.S. city may be in the face of such a situation, this …

Characteristics Of Children Attending Asthma Camp -- American Lung Association (Ala) In Nevada, 2008, Priyank Shetty

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study is based on data provided by American Lung Association (ALA) on the children participating in summer asthma camp in Las Vegas and Reno, Nevada. 56 children participated in the camp in 2008. Universal Health History Form was used which is a comprehensive form to be filled out by parent and physician. Pre-test and Post-test Asthma forms were used to ascertain asthma knowledge before and after the camp.

The purpose of this study was to assess the trigger knowledge of the camp attendees and the measure of agreement between Physician and Parent report of child's asthma severity. In Nevada, …

Self-Determination Theory In Motivation To Adopt Physical Activity In Older Adults: A Community Based Approach, Alastair Stewart

Theses: Doctorates and Masters

Australia has an increasingly aging population with increasing levels of physical inactivity. The potential detrimental effects of these two factors on the health of the community highlight the need to investigate methods to increase physical activity in older Australian adults. The study reported in this thesis formed part of the PATH (Physical Activity Time for Health) Project, a community-based research trial that compared two strategies to increase physical activity in underactive, 60-80 year old men (n = 66) and women (n = 188). Twelve recreation centres were randomised to either a supervised group based walking intervention with behavioural change components, …

Feasibility Study On Result-Based Financial Mechanisms For Mnch, Shehla Zaidi, Zulfiqar Ahmed Bhutta, Asad Saeed, Ajmal Agha, Ghulam Haider Akhund, Zohra Lassi, Farhan Saeed Vakani, Yasser Kureshi, Mohammad Faisal, Tanweer Hussain, Murad Charania

Community Health Sciences

No abstract provided.

Examining The Intrinsic Motivational Level Of Task And Ego Goal Oriented Athletes In The Xl Sports Acceleration Program, Kira Melisa Werstein

Dissertations and Theses @ UNI

Acceleration programs are a new and popular tool used by youth athletes to prepare for upcoming sports seasons. Acceleration programs train athletes in the areas of speed, agility, power, coordination, and strength. Each of these aspects is important in the development of an athlete and effects athletic performance. It is important that acceleration programs also consider intrinsic motivation, because it will help advance the performance of each athlete. The purpose of this study is to examine motivational levels in task and ego goal oriented athletes over the length of a session at the XL Sports Acceleration Program. The Task and …

The Relationship Between Cardiovascular Fitness And Risk Factors Of Type 2 Diabetes In Adults, La Toshia Burrell

Dissertations and Theses @ UNI

Obesity and overweight populations have increased dramatically in the last two decades in the United States causing a significant increase in the number of adults with type 2 diabetes. This alarming increase has become an important public health problem due to the associated diseases and health risks. As a result, there have been several programs developed specifically to help prevent or decrease the complications of type 2 diabetes. Physical fitness is an important component of many behavior modification programs. Research studies have conclusively shown beneficial effects of regular activity for disease risk reduction. However, many studies have examined associations between …

Children With Cleft Lips And/Or Palates In Early Childhood Classrooms : Overcoming Obstacles And Misconceptions, Angel Simons

Graduate Research Papers

One in 750 live births results in a baby born with a cleft lip and/or palate (CLP), making it the second most common birth impairment in the United States (Speltz, Endrig, Fisher, & Mason, 1997). Being born with a cleft lip and/or palate brings on many obstacles in a child's life.

Educators can help children born with cleft lip and/or palate by knowing: are there any correlations between how a child born with a cleft is treated by teachers and parents when it comes to teacher and/or parent expectations and perceptions; do children with clefts have distinct common personality or …

Results From A Mathematical Model For Human Monocytic Ehrlichiosis, H. Gaff, L. Gross, E. Schaefer

Biological Sciences Faculty Publications

Human monocytic ehrlichiosis (Ehrlichia chaffeensis), HME, is a tick-transmitted, rickettsial disease that has recently increased substantially in the USA from 142 reported cases in 2001 to 506 reported cases in 2005 [1,2]. There have been increasing surveys of tick populations over the past 10 years that have in turn supported the development of models for tick-borne disease transmission. Resulting HME models [3] suggest the importance of metapopulation structures, landscape environment parameters and periodic climatic effects in predicting the dynamics of HME transmission and the efficacy of control efforts, such as the reduction of the tick population through acaricide …

Development And Evaluation Of New Mask Protocols For Gene Expression Profiling In Humans And Chimpanzees, Donna M. Toleno, Gabriel Renaud, Tyra G. Wolfsberg, Munirul Islam, Derek E. Wildman, Kimberly D. Siegmund, Joseph G. Hacia

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cross-species gene expression analyses using oligonucleotide microarrays designed to evaluate a single species can provide spurious results due to mismatches between the interrogated transcriptome and arrayed probes. Based on the most recent human and chimpanzee genome assemblies, we developed updated and accessible probe masking methods that allow human Affymetrix oligonucleotide microarrays to be used for robust genome-wide expression analyses in both species. In this process, only data from oligonucleotide probes predicted to have robust hybridization sensitivity and specificity for both transcriptomes are retained for analysis.

Results

To characterize the utility of this resource, we applied our mask protocols …

A Three-Year-Old Boy With X-Linked Adrenoleukodystrophy And Congenital Pulmonary Adenomatoid Malformation: A Case Report, Ibrahim Abdulhamid, Sermin Saadeh, Nedim Cakan

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

X-linked adrenoleukodystrophy leads to demyelination of the nervous system, adrenal insufficiency, and accumulation of long-chain fatty acids. Most young patients with X-linked adrenoleukodystrophy develop seizures and progressive neurologic deficits, and die within the first two decades of life. Congenital or acquired disorders of the respiratory system have not been previously described in patients with X-linked adrenoleukodystrophy.

Case presentation

A 3-year-old Arabic boy from Yemen presented with discoloration of the mucous membranes and nail beds, which were considered cyanoses due to methemoglobinemia. He also had shortness of breath, fatigue, emesis and dehydration episodes for which he was admitted to …

Smi Of Bcl-2 Tw-37 Is Active Across A Spectrum Of B-Cell Tumors Irrespective Of Their Proliferative And Differentiation Status, Ayad M. Al-Katib, Yuan Sun, Anton Goustin, Asfar Azmi, Ben Chen, Amro Aboukameel, Ramzi M. Mohammad

Wayne State University Associated BioMed Central Scholarship

Abstract

The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy for treating B-cell tumors. We evaluated the efficacy of TW-37, a non-peptidic SMI of Bcl-2 against a range spectrum of human B-cell lines, fresh patient samples and animal xenograft models. Multiple cytochemical and molecular approaches such as acridine orange/ethidium bromide assay for apoptosis, co-immunoprecipitation of complexes and western blot analysis, caspase luminescent activity assay and apoptotic DNA fragmentation assay were used to demonstrate the effect of TW-37 on …

Biocompatibility Of Poly-Ε-Caprolactone-Hydroxyapatite Composite On Mouse Bone Marrow-Derived Osteoblasts And Endothelial Cells, Haiying Yu, Paul H. Wooley, Shang-You Yang

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Tissue-engineered bone may be developed by seeding the cells capable of both osteogenesis and vascularization on biocompatible composite scaffolds. The current study investigated the performance of mice bone marrow-derived osteogenic cells and endothelial cells as seeded on hydroxyapatite (HA) and poly-ε-caprolactone (PCL) composite scaffolds.

Methods

Mononuclear cells were induced to osteoblasts and endothelial cells respectively, which were defined by the expression of osteocalcin, alkaline phosphatase (ALP), and deposits of calcium-containing crystal for osteoblasts, or by the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) and von Willebrand factor (vWF), and the formation of a capillary network in Matrigel™ …

Brain Candy: Wayne State University School Of Medicine Journal Of Art And Literature, 1st Edition, Wayne State University School Of Medicine Writing Workshop, Wayne State University School Of Medicine Gold Humanism Honor Society

Gold Humanism Honor Society

The first edition of Brain Candy, distributed in August 2009 with a generous grant from the Gold Humanism Honor Society.

Brain Candy collects poetry, nonfiction essays, short fiction, photographs, and drawings to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. Features submissions from medical students, physicians, and School of Medicine staff.

Comorbidity And Repeat Admission To Hospital For Adverse Drug Reactions In Older Adults: Retrospective Cohort Study, Min Zhang, C D'Arcy J Holman, Sylvie D. Price, Frank M. Sanfilippo, David B. Preen, Max K. Bulsara

Medical Papers and Journal Articles

Objectives: To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults.

Design: Population based retrospective cohort study.Setting: All public and private hospitals in Western Australia.

Participants: 28 548 patients aged 60 years with an admission for an ADR during 1980-2000 followed for three years using the Western Australian data linkage system.

Results: 5056 (17.7%) patients had a repeat admission for an ADR. Repeat ADRs were associated with sex (hazard ratio 1.08, 95% confidence interval 1.02 to 1.15, for men), first admission in 1995-9 (2.34, 2.00 to 2.73), length of hospital stay (1.11, 1.05 …

Evidence For The Validity Of The Children’S Attraction To Physical Activity Questionnaire (Capa) With Young Children, Elizabeth Rose, Dawne Larkin, Beth P. Hands, Barbara Howard, Helen Parker

Health Sciences Papers and Journal Articles

Attraction to physical activity is important to an individual’s intrinsic motivation to engage in play, games and sports. While there are instruments designed to measure attraction to physical activity in middle childhood years, the lack of authentic measures in young children has impeded research in this area.

In this study we sought to address the validity of a scale to tap young children’s attraction to physical activity. Evidence for validity was based on internal consistency, content analysis, and factor structure.

Australian school children (180 boys and 154 girls) from school year two, aged six to eight years, were individually administered …

Adolescent Dietary Patterns Are Associated With Lifestyle Family Psycho-Social Factors, Gina L. Ambrosini, Wendy H. Oddy, Monique Robinson, Therese A. O'Sullivan, Beth P. Hands, Nick H. De Klerk, Sven Silburn, Stephen R. Zubrick, Garth E. Kendall, Fiona Stanley, Lawrence Beilin

Health Sciences Papers and Journal Articles

Background/ Objectives: Dietary intake during adolescence contributes to lifelong eating habits and the development of early risk factors for disease in adulthood. Few studies have examined the dietary patterns of adolescents and the social and environmental factors that may affect them during this life stage. The present study describes dietary patterns in a cohort of adolescents and examines their associations with socioeconomic factors, as well as parental and adolescent risk factor behaviours.

Design: A semi quantitative FFQ was used to assess study adolescents’ usual dietary intake over the previous year. Information was collected on family functioning and various socio economic …

Taking Be Proud! Be Responsible! To The Suburbs: A Replication Study, Elaine A. Borawski, Erika S. Trapl, Kimberly Adams-Tufts, Laura L. Hayman, Merdith A. Goodwin, Loren D. Lovegreen

Ellmer School of Nursing Faculty Publications

CONTEXT: An important phase of HIV prevention research is replicating successful interventions with different groups and in different settings.

METHODS: Be Proud! Be Responsible!, a successful intervention originally targeting black urban males and carried out in nonschool settings, was presented in health classes at urban and suburban schools with diverse student bodies. A group-randomized intervention study, which included 1,357 ninth and 10th graders from 10 paired schools in a Midwestern metropolitan area, was conducted in 2000-2002. Half the schools received the intervention, and half received a general health promotion program. Students' reports of their sexual behavior and selected cognitive mediators …

Surgical Smoke Evacuation Guidelines: Compliance Among Perioperative Nurses, Kay A. Ball

Theses and Dissertations

Smoke (plume) is produced when tissue is cut or coagulated with lasers or electrosurgery devices during surgery. Research has documented that surgical smoke creates a serious workplace hazard for over 500,000 healthcare workers. Toxic gases create an offensive odor, small particulate matter causes respiratory complications, and pathogens may be transmitted within the surgical smoke to the surgical team. Previous research notes that smoke evacuation recommendations are not being consistently followed by perioperative nurses.

The purpose of this study is to determine key indicators that are associated with compliance with smoke evacuation recommendations by perioperative nurses. The Diffusion of Innovation theory …

Identification And Characterization Of Prevotella Intermedia 17 Toll-Like Receptor 2 Ligands, Jamie Feng-Hsia Yuan

Theses and Dissertations

Periodontal disease is one of the most prevalent human diseases affecting millions of individuals. Bacteria are the trigger of the host response that then results in initiation and progression of periodontal disease. The interactions between the host and the bacteria, although very complex and intricate, are not well understood. Species of gram-negative anaerobic bacteria implicated in the development of periodontal disease include Porphyromonas gingivalis and Prevotella intermedia. The goal of our study was to identify P. intermedia surface proteins interacting with TLR2 receptor. Using Cy5-labeled surface proteins we identified multiple proteins using our capture assay. The interaction of three …

An Assessment Of Burnout In Undergraduate Athletic Training Education Program Directors, Jessica M. Walter, Bonnie L. Van Lunen, Stacy E. Walker, Zahra C. Ismaeli

Rehabilitation Sciences Faculty Publications

Context: Athletic training education program directors (ATEPDs) often manage their time among students, program administration, and patient care.

Objective: To assess the level of burnout in ATEPDs and to determine the relationship between burnout and various demographics of ATEPDs.

Design: Cross-sectional study.

Setting: Public and private colleges and universities nationwide.

Patients or Other Participants: Two hundred forty-nine ATEPDs of undergraduate athletic training education programs accredited by the Commission on Accreditation of Athletic Training Education.

Intervention(s): We administered the Maslach Burnout Inventory (MBI) to all participants.

Main Outcome Measure(s): The MBI consisted of 21 items assessing 3 characteristics of burnout: emotional …

Pulmonary Delivery Of Anorectic Gut Secreted Peptides For Appetite Suppression In Rats, Priya Nadkarni

Theses and Dissertations

This dissertation project aimed to demonstrate that pulmonary delivery of two anorectic gut secreted peptides, peptide YY (PYY) and oxyntomodulin (OXM) enabled food intake suppression and reduced body weight gain in rats via their systemic absorption from the lung and interaction with the brain. After PYY and OXM were administered to the lungs at varying doses, food intake and body weight gain were monitored in freely feeding rats. Significant 30-35 % food intake suppression was achieved for 4-6 h following pulmonary administration of endogenously active PYY3-36 and OXM1-37 at 0.80 and 0.50 mg/kg, respectively. Moreover, when administered daily for 7 …

A Longitudinal Examination Of How Hospital Provision Of Home Health Services Changed After The Implementation Of The Balanced Budget Act Of 1997: Does Ownership Matter?, Tiang-Hong Chou

Theses and Dissertations

By using a natural experiment approach and longitudinal national hospital data, this study sheds light on the objective functions of hospitals with different ownership forms by comparing their relative reductions in HH provision after the implementation of the BBA. The empirical findings reveal that for-profit hospitals behave differently as compared to public and private nonprofit hospitals, due to their different operational objectives. While the response of for-profit hospitals is consistent with the profit-maximizer model, both public and private nonprofit ownership types behave consistently in accordance with the model of two-good producers whose objective is to maximize market outputs for meeting …

Predictors Of Situation Awareness In Graduate Student Registered Nurse Anesthetists, Suzanne Wright

Theses and Dissertations

ABSTRACT PREDICTORS OF SITUATION AWARENESS IN GRADUATE STUDENT REGISTERED NURSE ANESTHETISTS Suzanne M. Wright, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Major Director: J. James Cotter, Ph.D. Situation awareness (SA) is defined as one’s perception of the elements of the environment, the comprehension of their meaning, and the projection of their status in the near future. Stated more simply, SA is knowing what is going on around you. The concept of SA is well known in the field of aviation which is …

Determinants Of Nursing Home Performance: Examining The Relationship Between Quality And Efficiency, Nailya Delellis

Theses and Dissertations

Determinants of nursing home performance: examining the relationship between quality and efficiency By Nailya O. DeLellis, MPH, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Director: Dr. Yasar Ozcan, Professor, Department of Health Administration To assess the relationship between quality of care and efficiency of nursing homes this study used 10% random sample of non-hospital based nursing homes of size 20-360 beds and occupancy rate of 5-100% in OSCAR database 2008 (n=1430). Data Envelopment Analysis was used to calculate efficiency score and Structural …

Molecular Modeling Studies Of Heparin And Heparin Mimetics Binding To Coagulation Proteins, Chandravel Krishnasamy

Theses and Dissertations

Heparin, a glycosaminoglycan (GAG), is a complex biopolymer of varying chain length and consisting of uronic acid and glucosamine residues, which are sulfated at various positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of antithrombin, without which the heparin is incapable of binding to antithrombin. Although heparin is a commonly used anticoagulant, it suffers from serious …

Risk Of Dementia Associated With Elevated Plasma Homocysteine In A Latin American Population, Inara J. Chacon, Aldrín E. Molero, Gloria Pino-Ramírez, José A. Luchsinger, Joseph H. Lee, Gladys E. Maestre

School of Medicine Publications

The relationship between total homocysteine (tHcy) and dementia risk remains controversial, as the association varies among populations and dementia subtypes. We studied a Venezuelan population that has high prevalence of both elevated tHcy and dementia. We tested the hypotheses that (1) elevated tHcy is associated with increased dementia risk, (2) the risk is greater for vascular dementia (VaD) than for Alzheimer’s disease (AD), and (3) a history of stroke may partly explain this association. 2100 participants (≥55 years old) of the Maracaibo Aging Study underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. Elevated tHcy was significantly associated with dementia, primarily VaD. …

Parameter Optimization For Image Denoising Based On Block Matching And 3d Collaborative Filtering, Ramu Pedada, Emin Kugu, Jiang Li, Zhanfeng Yue, Yuzhong Shen, Josien P.W. Pluim (Ed.), Benoit M. Dawant (Ed.)

Electrical & Computer Engineering Faculty Publications

Clinical MRI images are generally corrupted by random noise during acquisition with blurred subtle structure features. Many denoising methods have been proposed to remove noise from corrupted images at the expense of distorted structure features. Therefore, there is always compromise between removing noise and preserving structure information for denoising methods. For a specific denoising method, it is crucial to tune it so that the best tradeoff can be obtained. In this paper, we define several cost functions to assess the quality of noise removal and that of structure information preserved in the denoised image. Strength Pareto Evolutionary Algorithm 2 (SPEA2) …