Medicine and Health Sciences Commons^™

Predicting Flavonoid Ugt Regioselectivity With Graphical Residue Models And Machine Learning., Arthur Rhydon Jackson

Electronic Theses and Dissertations

Machine learning is applied to a challenging and biologically significant protein classification problem: the prediction of flavonoid UGT acceptor regioselectivity from primary protein sequence. Novel indices characterizing graphical models of protein residues are introduced. The indices are compared with existing amino acid indices and found to cluster residues appropriately. A variety of models employing the indices are then investigated by examining their performance when analyzed using nearest neighbor, support vector machine, and Bayesian neural network classifiers. Improvements over nearest neighbor classifications relying on standard alignment similarity scores are reported.

Manifest Greatness Version5 By Marc Guerrero With Tato Malay, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version5 by Marc Guerrero with Tato Malay

Manifest Greatness Version3 By Marc Guerrero With Jay Fajardo, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version3 by Marc Guerrero with Jay Fajardo

Manifest Greatness Version2 With Danielle Van Asch-Prevot, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version2 by Marc Guerrero with Danielle van Asch-Prevot

Manifest Greatness... Panahon Ng Mga Filipino Ang 21st Century: Ang Asian Century (Ang Pagpapanumbalik Sa Likas Na Karangalan Ng Lahat Ng Filipino Sa Buong Mundo), Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS Panahon ng mga Filipino ang 21st century: Ang Asian Century (Ang pagpapanumbalik sa likas na Karangalan ng lahat ng Filipino sa buong mundo) Manifest Greatness is a work-in-progress Manifesto of, for and by Filipino citizens of the world in synergy with foreign national friends of the Filipino people worldwide in pursuit of genuine entrepreneurial wisdom

Assessment Of Internationalised Domain Name Homograph Attack Mitigation, Peter Hannay, Christopher Bolan

Australian Information Security Management Conference

With the advent of internationalised domains the threat posed by non-english character sets has eventuated. Whilst this phenomenon remains well known in the development and internet industry the actual implementations of popular applications have been tested to determine their resilience to homograph based attack. The research found that most provided features that overcome such attacks, but there remain a few notable exceptions. Should an attacker take advantage of such oversights a victim would likely not be able to spot a fraudulent site or email and thus provide a perfect platform for subsequent attack.

Challenges In Improving Information Security Practice In Australian General Practice, Donald C. Mcdermid, Rachel J. Mahncke, Patricia A. Williams

Australian Information Security Management Conference

The status of information security in Australian medical general practice is discussed together with a review of the challenges facing small practices that often lack the technical knowledge and skill to secure patient information by themselves. It is proposed that an information security governance framework is required to assist practices in identifying weaknesses and gaps and then to plan and implement how to overcome their shortcomings through policies, training and changes to processes and management structure.

Measuring Information Security Governance Within General Medical Practice, Rachel J. Mahncke, Donald C. Mcdermid, Patricia A. Williams

Australian Information Security Management Conference

Information security is becoming increasingly important within the Australian general medical practice environment as legal and accreditation compliance is being enforced. Using a literature review, approaches to measuring information security governance were analysed for their potential suitability and use within General Practice for the effective protection of confidential information. The models, frameworks and guidelines selected were analysed to evaluate if they were Key Performance Indicator (KPI), or process driven; whether the approach taken was strategic, tactical or operational; and if governance or management assessment tools were presented. To measure information security governance, and be both effective and practical, the approach …

The Development Of An Advanced Filial Therapy Model, Amy Cathleen Wickstrom

Loma Linda University Electronic Theses, Dissertations & Projects

This study sought to develop an advanced filial therapy model by examining the experiences of seven parents who participated in a preliminary advanced filial therapy intervention. These parents had previously completed a 10-week basic filial therapy model called Child Parent Relationship Therapy. A phenomenological qualitative design was employed, wherein data was obtained from parent playtime notes, researcher field notes, group process transcriptions, and focus groups. Parent experiences of the intervention were examined from a systems-relational lens, and four categories emerged, which include relational epiphanies, enhanced understanding of the playtimes, model format, and skill development. Additionally, a variety of themes were …

Survival Analysis With Error-Prone Time-Varying Covariates: A Risk Set Calibration Approach, Xiaomei Liao, David M. Zucker, Yi Li, Donna Spiegelman

Harvard University Biostatistics Working Paper Series

No abstract provided.

A Privacy Framework For Mobile Health And Home-Care Systems, David Kotz, Sasikanth Avancha, Amit Baxi

Dartmouth Scholarship

In this paper, we consider the challenge of preserving patient privacy in the context of mobile healthcare and home-care systems, that is, the use of mobile computing and communications technologies in the delivery of healthcare or the provision of at-home medical care and assisted living. This paper makes three primary contributions. First, we compare existing privacy frameworks, identifying key differences and shortcomings. Second, we identify a privacy framework for mobile healthcare and home-care systems. Third, we extract a set of privacy properties intended for use by those who design systems and applications for mobile healthcare and home-care systems, linking them …

2009 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library, Michael Schwartz Ph.D.

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti. Dr. Michael Schwartz was the honored guest.

Mpcs: Mobile-Based Patient Compliance System For Chronic Illness Care, Guanling Chen, Bo Yan, Minho Shin, David Kotz, Ethan Burke

Dartmouth Scholarship

More than 100 million Americans are currently living with at least one chronic health condition and expenditures on chronic diseases account for more than 75 percent of the $2.3 trillion cost of our healthcare system. To improve chronic illness care, patients must be empowered and engaged in health self-management. However, only half of all patients with chronic illness comply with treatment regimen. The self-regulation model, while seemingly valuable, needs practical tools to help patients adopt this self-centered approach for long-term care. \par In this position paper, we propose Mobile-phone based Patient Compliance System (MPCS) that can reduce the time-consuming and …

A Comparison Of Frequentist And Bayesian Approaches To The Estimation Of Long-Stay Per-Diems, Jeff Hatcher, Jason M. Sutherland

Dartmouth Scholarship

Within many diagnosis related group (DRG) systems, there is recognition that a single cost weight per DRG is not suitable, and that cost weights should take into account extremely lengthy hospital stays. Long lengths of stay are considered to be due to factors largely beyond the control of the hospital, and a single weight per DRG would potentially place hospitals under financial risk.

Within Canada's acute-care, inpatient grouping methodology - Case Mix Groups (CMG+) - long-stay episodes represent approximately 4.5% of all discharges. Within a CMG (analogous to DRG), the cost weight assigned to long-stay cases consists of the typical …

Lot Quality Assurance Sampling (Lqas) And The Mozambique Malaria Indicator Surveys, Caitlin Biedron, Marcello Pagano, Bethany L. Hedt, Albert Kilian, Amy Ratcliffe, Samuel Mabunda, Joseph J. Valadez

Harvard University Biostatistics Working Paper Series

No abstract provided.

Control Of Electrochemical And Ferryloxy Formation Kinetics Of Cyt P450s In Polyion Films By Heme Iron Spin State And Secondary Structure, Sadagopan Krishnan, Amila Abeykoon, John B. Schenkman, James F. Rusling

UCHC Articles - Research

Voltammetry of cytochrome P450 (cyt P450) enzymes in ultrathin films with polyions was related for the first time to electronic and secondary structure. Heterogeneous electron transfer (hET) rate constants for reduction of the cyt P450s depended on heme iron spin state, with low spin cyt P450cam giving a value 40-fold larger than high spin human cyt P450 1A2, with mixed spin human P450 cyt 2E1 at an intermediate value. Asymmetric reduction–oxidation peak separations with increasing scan rates were explained by simulations featuring faster oxidation than reduction. Results are consistent with a square scheme in which oxidized and reduced forms of …

Activity-Aware Ecg-Based Patient Authentication For Remote Health Monitoring, Janani Sriram, Minho Shin, Tanzeem Choudhury, David Kotz

Dartmouth Scholarship

Mobile medical sensors promise to provide an efficient, accurate, and economic way to monitor patients' health outside the hospital. Patient authentication is a necessary security requirement in remote health monitoring scenarios. The monitoring system needs to make sure that the data is coming from the right person before any medical or financial decisions are made based on the data. Credential-based authentication methods (e.g., passwords, certificates) are not well-suited for remote healthcare as patients could hand over credentials to someone else. Furthermore, one-time authentication using credentials or trait-based biometrics (e.g., face, fingerprints, iris) do not cover the entire monitoring period and …

Activity-Aware Ecg-Based Patient Authentication For Remote Health Monitoring, Janani Sriram, Minho Shin, Tanzeem Choudhury, David Kotz

Dartmouth Scholarship

Mobile medical sensors promise to provide an efficient, accurate, and economic way to monitor patients' health outside the hospital. Patient authentication is a necessary security requirement in remote health monitoring scenarios. The monitoring system needs to make sure that the data is coming from the right person before any medical or financial decisions are made based on the data. Credential-based authentication methods (e.g., passwords, certificates) are not well-suited for remote healthcare as patients could hand over credentials to someone else. Furthermore, one-time authentication using credentials or trait-based biometrics (e.g., face, fingerprints, iris) do not cover the entire monitoring period and …

Analysis Of Subgroup Data In Clinical Trials, Kao-Tai Tsai, Karl E. Peace

Biostatistics Faculty Presentations

This conference abstract was published in the Proceedings of the Sixteenth Annual Biopharmaceutical Applied Statistics Symposium.

Agenda: World Energy Justice Conference And Appropriate Technology Arcade, University Of Colorado Boulder. Center For Energy & Environmental Security, University Of Colorado Boulder. School Of Law

World Energy Justice Conference (October 23-24)

The 2009 CEES Energy Justice Conference took place at the University of Colorado Law School on October 23rd and 24th, 2009. It featured 11 sessions, more than 40 speakers, and attracted over 200 attendees. The Conference brought together leading international and U.S. decision-makers in politics, engineering, public health, law, business, economics, and innovators in the sciences to explore how best to address the critical needs of the energy-oppressed poor (EOP) through long-term interdisciplinary action, information sharing, and deployment of appropriate sustainable energy technologies (ASETs).

The Colorado Journal of International Environmental Law & Policy (CJIELP) at the University of Colorado Law …

Causal Inference In Epidemiological Studies With Strong Confounding, Kelly L. Moore, Romain S. Neugebauer, Mark J. Van Der Laan, Ira B. Tager

U.C. Berkeley Division of Biostatistics Working Paper Series

One of the identifiabilty assumptions of causal effects defined by marginal structural model (MSM) parameters is the experimental treatment assignment (ETA) assumption. Practical violations of this assumption frequently occur in data analysis, when certain exposures are rarely observed within some strata of the population. The inverse probability of treatment weighted (IPTW) estimator is particularly sensitive to violations of this assumption, however, we demonstrate that this is a problem for all estimators of causal effects. This is due to the fact that the ETA assumption is about information (or lack thereof) in the data. A new class of causal models, causal …

Unlv Magazine, Matthew K. Jacobsen, Holly Ivy De Vore, Lisa Arth, Cate Weeks, Greg Lacour, Tony Allen, Afsha Bawany, Barbara Cloud, Gian Galassi, Phil Hagen, Karyn S. Hollingsworth, Michelle Mouton, Erin O'Donnell

UNLV Magazine

No abstract provided.

Santa Clara Magazine, Volume 51 Number 2, Fall 2009, Santa Clara University

Santa Clara Magazine

16 - POLITICS AND RELIGION: STILL ON A COLLISION COURSE? An interview with Avraham Burg, former speaker of the Israeli Knesset. Plus excerpts from talks by E.J. Dionne Jr., Lisa Sowle Cahill '70, and Michael Eric Dyson.

20 - THE GULF OF WONDER By Emily Elrod '05. With a movie, Patrick McVeigh '78 offers investors a unique opportunity: Wake up the citizens of America and help them save one of the Seven Natural Wonders of the World. Plus, a 30 percent return.

24 - SEASON PREMIERE: "RESURRECTION" By Karen Crocker Snell. Forensic investigator Horatio Caine lies facedown in a pool …

South Dakota Thriving, Fall 2009, College Of Agriculture &. Biological Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

Table of Contents:
[Page] 2 Growing Farmers Markets: South Dakota Cooperative Extension Service Helps Develop and Grow Booming Homegrown markets
[Page] 4 Lighari Leads Restructuring of Extension: Director of South Dakota Cooperative Extension Service Focuses on Building Relationships
[Page} 6 South Dakota's Newest Research Station: The Addition of the SDSU Cow Camp Means Another Tremendous Resource for South Dakota and SDSU
[Page] 8 SDSU Rodeo Builds World Champs: Focus on Academics and Team Leads to Success Inside Both the Classroom and the Arena
|[Page] 12 Behind the Scenes in SDSU's Anatomy Lab: SDSU's Hands-On Anatomy Lab Gives Students the Edge …

Proteomic And Phospho-Proteomic Profile Of Human Platelets In Basal, Resting State: Insights Into Integrin Signaling, Amir H. Qureshi, Vineet Chaoji, Dony Maiguel, Mohd Hafeez Faridi, Constantinos J. Barth, Saeed M. Salem, Mudita Singhal, Darren Stoub, Bryan Krastins, Mitsunori Ogihara, Mohammed J. Zaki, Vineet Gupta

Faculty Work Comprehensive List

During atherogenesis and vascular inflammation quiescent platelets are activated to increase the surface expression and ligand affinity of the integrin αIIbβ3 via inside-out signaling. Diverse signals such as thrombin, ADP and epinephrine transduce signals through their respective GPCRs to activate protein kinases that ultimately lead to the phosphorylation of the cytoplasmic tail of the integrin αIIbβ3 and augment its function. The signaling pathways that transmit signals from the GPCR to the cytosolic domain of the integrin are not well defined. In an effort to better understand these pathways, we employed a combination of proteomic profiling and computational analyses of isolated …

Causal Inference For Nested Case-Control Studies Using Targeted Maximum Likelihood Estimation, Sherri Rose, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

A nested case-control study is conducted within a well-defined cohort arising out of a population of interest. This design is often used in epidemiology to reduce the costs associated with collecting data on the full cohort; however, the case control sample within the cohort is a biased sample. Methods for analyzing case-control studies have largely focused on logistic regression models that provide conditional and not marginal causal estimates of the odds ratio. We previously developed a Case-Control Weighted Targeted Maximum Likelihood Estimation (TMLE) procedure for case-control study designs, which relies on the prevalence probability q0. We propose the use of …

Ethical Issues In Graduate Research, William J. Frey

Ethics in Science and Engineering National Clearinghouse

(Caution! This module is being published in an incomplete, preliminary version. Later edited and fuller versions will follow.) "Graduate Education in Research Ethics for Scientists and Engineers" is a project funded by the National Science Foundation (SES 0629377) to design a pilot program in research ethics for graduate students in science and engineering. This project is built around three workshops: (1) a Graduate Awareness Workshop introduces students to fundamental ethical issues in research, (2) a Moral Deliberation Workshop acquaints students with the skills of moral deliberation, (3) a Case Analysis Workshop uses realistic scenarios to allow students to practice decision-making …

Progress Toward The Synthesis Of A Truncated Ergoline, Ryan D. Enck, Matthew Hart

Student Summer Scholars Manuscripts

Many people are diagnosed with thyroid related disorders, and many more are unaware of their existing thyroid problems. T1AM, a naturally occurring metabolite of the thyroid hormone (TH), has been shown to activate the Trace Amine Associated Receptor 1 (TAAR1) and exhibits effects that oppose those of the TH. It is, therefore, likely that there is regulatory relationship between T1AM and the TH. In order to better understand this relationship, a compound must be developed that will effectively block TAAR1. Previously our lab has examined the two different mirror images of apomorphine. One of the mirror images inhibited and the …

Professional Ethics-Responsible Conduct Of Research Training: Making Sense Of Complex Problems, Michael D. Mumford, Shane Connelly, Ryan P. Brown, Lynn D. Devenport, Stephen T. Murphy, Alison L. Antes

Ethics in Science and Engineering National Clearinghouse

General Course Abstract

This two-day seminar format course exposes students to the complexities involved in real-world ethical decision-making. It provides students with strategies, or tools, for understanding and thinking through ethical problems to arrive at a decision. Students practice working with these strategies by applying them to realistic, complex cases.

Day 1 Abstract

During the first day of the course, guidelines and principles for ethical research practices are discussed. It is emphasized that students must apply guidelines in a context to arrive at a decision, and the course provides guidance on this decision-making process. Next, students learn about the personal …

Impact Of Ambient Air Pollution On Survival Of Renal Transplant Recipients, Rhonda Kristine Hwang

Loma Linda University Electronic Theses, Dissertations & Projects

There is increasing evidence that ambient air pollution is associated with coronary heart disease morbidity and mortality. This research has focused on the general public and less so on possible sensitive subgroups even though these may have even greater susceptibility to adverse effects of ambient air pollution. With highly prevalent traditional as well as nontraditional risk factors, renal transplant recipients may potentially be a sensitive subgroup. The purpose of this study was to evaluate the possible effect of between long-term exposure to air pollution on the risk of CHD mortality among renal transplant recipients. This cohort study includes 32,239 adult, …