Medicine and Health Sciences Commons^™

Huge Retroperitoneal Liposarcoma As The Initial Presentation Of Sciatica: A Casereport, Li-Ling Lin, Ssu-Yuan Chen, Chi-Lun Rau, Shin-Liang Pan, Yu-Wen Tien

Rehabilitation Practice and Science

Background: Retroperitoneal liposarcoma is one of the common soft-tissue tumors that occur in the retroperitoneal cavity. It often invades adjacent structures and causes symptoms of gastrointestinal or urinary tract infection. However, it rarely causes sciatica by compressing the lumbosarcral nerve roots. A recent reviewarticle of the domestic literatures revealed that this is the first casereport on sciatica caused by retroperitoneal liposarcoma.Case: We present the case of a 29-year-old man who complained of left knee pain for half a year. The pain gradually progressed to his left lateral calf. Sciatica was suspected based on his clinical symptoms and electrodiagnostic studies. However, …

The Effect Of A Health Promotion Program On Overweight Polio Survivors, Yen-Nung Lin, Chi-Yang Hsu, Chyan-Yeong Wang, Kwang-Hwa Chang, Tsan-Hon Liou

Rehabilitation Practice and Science

Although health promotion issues specific to people with physical disabilities have received much attention in the last ten years, related clinical trials studying the efficacy and viability of these programs are lacking. In this pilot study, we implemented a short-term health promotion intervention for overweight/obese post-polio survivors. The study design included a three-month intervention containing exercise, diet education and health behavior modification, a before-and-after comparison, and a 12-month follow-up.Thirty one subjects were enrolled. They were divided into three groups by their mobility ability. Group 1 was comprised of those who could walk independently without an orthosis; group 2 subjects walked …

Aphasia In A Congenital Deaf Man: A Casereport, Shu-Yi Wang, Jin-Cherng Chen, Huei-Ting Chen

Rehabilitation Practice and Science

Congenitally deaf persons don't have the ability to communicate verbally due to profound hearing impairment. Thus, they rely on words and sign language to communicate with others. Physicians tend to pay less attention to people who can't communicate verbally. We report the case of a 45-year-old congenitally deaf man who developed a left frontotemporal brain tumor. He was right-handed. As a result of the tumor, he lost both the ability to form words and the sign language he had relied upon to communicate with others. He recovered some ability to communicate 6 months after surgery. He was able to use …

Transient Osteoporosis Of The Hip During Pregnancy: A Casereport, Wen-Chuan Pai, Ching-Yang Lin, Mu-Jung Kao, Fong-Cheng Lin

Rehabilitation Practice and Science

Transient osteoporosis, also called ”bone marrow edema syndrome”, is a rare disorder of unknown etiology. It primarily affects women in the third trimester of pregnancy as well as middle-aged, overweight men, and the hip joint is most commonly involved. The main symptom of transient osteoporosis of the hip is a sudden onset of pain at the lateral aspect of the hip. Mild limitation of hip range of motion is often present. A 36-year-old woman presented to our outpatient department 5 weeks after cesarean section with bilateral hip pain, which had begun suddenly during her eighth month of pregnancy. Magnetic resonance …

Reliability And Validity Of The Iliac Crest Leveling And Paper Thickness Correction Method For Measuring Functional Leg-Length Discrepancy, Chun-Yi Lin, Tzu-Jung Wu, His-Hui Sung, Ke-Shin Jian, Chi-Chung Ho

Rehabilitation Practice and Science

The objective of this study is to determine the reliability and validity of a clinical measurement for functional leg-length discrepancy (LLD) using the level and paper thickness correction (LPC) method to determine intra-rater and inter-rater reliability and validity. We induced a simulated LLD (5-30 mm) for each subject twice in a block-simulating group (n=17), none of whom had an apparent LLD. The X-ray group (n=7), who had LLD, were measured using radiographs to measure the LLD. The examiner performed the LPC method in both groups by adjusting the bilateral height of the top iliac crest margin via the level and …

Transcriptional Adaptations Following Exercise In Thoroughbred Horse Skeletal Muscle Highlights Molecular Mechanisms That Lead To Muscle Hypertrophy, Beatrice A. Mcgivney, Suzanne S. Eivers, David E. Machugh, James N. Macleod, Grace M. O'Gorman, Stephen D.E. Park, Lisa M. Katz, Emmeline W. Hill

Veterinary Science Faculty Publications

BACKGROUND: Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses to exercise in skeletal muscle. Exercise stimulates immediate early molecular responses as well as delayed responses during recovery, resulting in a return to homeostasis and enabling long term adaptation. Global mRNA expression during the immediate-response period has not previously been reported in skeletal muscle following exercise in any species. Also, global gene expression changes in equine skeletal muscle following exercise have not been reported. Therefore, to identify novel genes and key regulatory pathways responsible for exercise adaptation we have used equine-specific …

Fagerstrom Test For Nicotine Dependence Vs Heavy Smoking Index In A General Population Survey, M. Pérez-Ríos, M. I. Santiago-Pérez, B. Alonso, A. Malvar, X. Hervada, Jose De Leon

Psychiatry Faculty Publications

BACKGROUND: The Fagerström Test for Nicotine Dependence (FTND) is used for assessing nicotine dependence. A shorter test derived from the FTND used for the general population is the Heavy Smoking Index (HSI) (six questions vs. two). The objective of this study is to compare the validity of the HSI versus the FTND.

METHODS: A survey of tobacco use in the general population was carried out in the northern Spanish region of Galicia using both the FTND and the HSI to study a representative sample of 1655 daily smokers. The HSI was compared with the FTND, considered the gold standard. Measures …

Ccl2 Responses To Mycobacterium Tuberculosis Are Associated With Disease Severity In Tuberculosis, Zahra Hasan, Jacqueline M. Cliff, Hazel M. Dockrell, Bushra Jamil, Muhammad Irfan, Mussarat Ashraf, Rabia Hussain

Section of Pulmonary & Critical Care

Background

Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNγ, TNFα and downmodulatory IL10 play a central role in the restriction of M. tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity.

Methodology

We investigated live M. tuberculosis- and M. bovis BCG- induced peripheral blood mononuclear cell responses in patients with tuberculosis (TB) and healthy endemic controls (ECs, n = 36). TB patients comprised pulmonary (PTB, n = 34) and extrapulmonary groups, subdivided into those with less severe localized extrapulmonary TB (L-ETB, n = 16) or severe disseminated ETB (D-ETB, …

Rearrangement Of The Rna Polymerase Subunit H And The Lower Jaw In Archaeal Elongation Complexes, Sebastian Grünberg, Christoph Reich, Mirijam E. Zeller, Michael S. Bartlett, Michael Thomm

Biology Faculty Publications and Presentations

The lower jaws of archaeal RNA polymerase and eukaryotic RNA polymerase II include orthologous subunits H and Rpb5, respectively. The tertiary structure of H is very similar to the structure of the C-terminal domain of Rpb5, and both subunits are proximal to downstream DNA in pre-initiation complexes. Analyses of reconstituted euryarchaeal polymerase lacking subunit H revealed that H is important for open complex formation and initial transcription. Eukaryotic Rpb5 rescues activity of the ΔH enzyme indicating a strong conservation of function for this subunit from archaea to eukaryotes. Photochemical cross-linking in elongation complexes revealed a striking structural rearrangement of RNA …

Mimosa Humilis: A Multicentric Double Blind Homoeopathic Pathogenetic Trial, C. Nayak, Vikram Singh, V.A. Siddiqui, Rajpal Rajpal, S. Prakash, Yogendra Rai, N. R. Dey

Indian Journal of Research in Homoeopathy

Objective: To elicit the pathogenetic response of the drug Mimosa humilis in homoeopathic potencies on healthy human beings. Methodology: Drug Mimosa humilis was proved through double-blind placebo-controlled method. The study was conducted at 2 centers. The drug was proved in two potencies (6C and 30C) on 16 apparently healthy volunteers who were selected after pre-trial medical examination by the specialists and after doing routine pathological investigations. The volunteers consumed 56 doses (04 doses per day for 14 days) of each potency in three phases (including 1" phase in placebo) for a varying period. The symptoms generated during the trial period …

Quality Assurance Of Raw Drug Euphorbia Hypericifolia Through Microscopic Studies., H.C. Gupta, P. Padma Rao

Indian Journal of Research in Homoeopathy

The present paper reveals morphological and anatomical characterization of the raw material of the plant Euphorbia hypericifolia L. of family Euphorbiaceae. It includes macroscopy, qualitative, quantitative microscopy and powder studies of root, stem and leaf of the plant to ensure correct botanical identity of raw material, which is used for preparation of homoeopathic drug Euphorbia hypericifolia having clinical indications for treatment of constipation and headache.

Tarentula Hispanica- A Multicentric Clinical Verification Study Conducted By Ccrh, P. S. Chakraborty, Anil Khurana, J. P. Singh, M. K. Rai, Pramodji Singh, A. K. Vichitra, A. K.N. Singh, Deepa Chakraborty, D. K. Singh, Hari Singh, Mohan Singh, M. N. Sinha, Rajpal Rajpal, R. K. Rai, S. Prakash, S. D. Pathak, S. R. Bhagat, Vikram Singh, Vijay K. Paul, V. K. Singh, Yogendra Rai, V. A. Siddiqui

Indian Journal of Research in Homoeopathy

Tarentula hispanica is a known drug in Homoeopathy but it has not been used extensively. Its use has been reported in homoeopathic literature for various clinical conditions like depression, headache, hiccough, quinsy, cystitis, vertigo, otorrhoea, pyrosis, constipation, seminal emission, neuralgia of legs, cough, dyspnoea and fever. Most of these symptoms have been reconfirmed in the study conducted by Central Council for Research in Homoeopathy (CCRH). Besides these, in conditions like conjunctivitis, dyspepsia, flatulence, loose stool, pain in deltoid region, pain in shoulder joints and in pimple-like eruptions it is also found useful. A total of 2794 patients were studied in …

Biochemical And Haematological Evaluation Of Homoeopathic Drug Tribulus Terrestris In Rats, E. N. Sundaram, K. P. Singh, P. Uma Maheswara Reddy, K. R.J. Nair, C. Nayak

Indian Journal of Research in Homoeopathy

Although in Homoeopathy different potencies of Tribulus terrestris (Ikshugandha) have been commonly prescribed in urinary affections, especially dysuria and in debilitated status of the sexual organs, no scientific experimental data has been documented to establish their safe use. The present study was, therefore, undertaken to generate preliminary data on the biochemical and haematological parameters with homoeopathic drug Tribulus terrestris. The four potencies (3x, 6x, 12x and 30c) of this drug were administered orally in daily doses of 0.1ml, 0.2ml and 0.5ml/rat for 14 days and their effects on biochemica/ and haematological parameters were studied on 21" and 28" day during …

Proteolytic Regulation Of Toxin-Antitoxin Systems By Clppc In Staphylococcus Aureus, Niles P. Donegan, Earl T. Thompson, Zhibiao Fu, Ambrose L. Cheung

Dartmouth Scholarship

Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. However, if TA production is interrupted, antitoxin levels decrease, and the cognate toxin is free to inhibit the specific cellular component, such as mRNA, DnaB, or gyrase. To date, antitoxin degradation has been studied only in E. coli, so it remains unclear whether similar mechanisms of regulation …

Homoeopathic Drugs Natrum Sulphuricum And Carcinosin Prevent Azo Dye Induced Hepatocarcinogenesis In Mice, Nandini Bhattacharjee, Pathikrit Banerjee, Anisur Khuda Bukhsh

Indian Journal of Research in Homoeopathy

The study was undertaken to examine whether Carcinosin-200 (Car-200) could provide additional ameliorative effect, if used intermittently with Natrum sulphuricum-30 (Nat sulph-30) against hepatocarcinogenesis induced by chronic feeding of p-dimethylaminoazobenzene (p-DAB) and phenobarbital (PB) in mice (Mus musculus). Mice were randomly divided into seven sub-groups: (i) normal untreated; (ii) normal+succussed alcohol; (iii) p-DAB (0.06%) + PB (0.05%); (iv) p-DAB + PB +succussed alcohol (v) p-DAB+PB+Nat sulph-30, (vi) p-DAB+PB+Car-200, and (vii) p-DAB+PB+ Nat sulph-30+Car-200. They were sacrificed at 30, 60, 90 and 120 days for assessment of genotoxicity through cytogenetical end-points like chromosome aberrations, micronuclei, mitotic Index and sperm head anomaly …

Treating Benign Prostatic Hyperplasia In Elderly Men With Homoeopathy- A Series Of Eleven Cases, G. Ravi Chandra Reddy, Praveen Oberoi, Vikram Singh, C. Nayak

Indian Journal of Research in Homoeopathy

Background & Objectives: Benign prostatic hyperplasia is rarely life threatening, but often affects the individual's quality of life in varying degrees. The success rate in treating this condition with conventional therapy is limited and sometimes, treatment follows with side effects. If medical treatment fails, the physician determines the patient as a candidate for surgery. Though a few case records are documented in the past about the success of homoeopathic medicines in treating patients suffering from BPH, yet they lack proper quantitative assessment. Therefore, an observational study was undertaken with an objective to ascertain the usefulness of predefined homoeopathic medicines in …

A Randomized Double Blind Clinical Trial Of A Homoeopathic Medicine In The Treatment Of Trophic Ulcer And Neuropathy In Leprosy, D. Chakraborty, T. Chakraborty, S. Das, J. Sengupta

Indian Journal of Research in Homoeopathy

Introduction: Leprosy is a disease of global concern not only because of its potential to affect large number of people and its continued transmission but also because of the occurrence of deformities In a great proportion of patients. It is also a fact that multi-drug regimen has been effective in killing Mycobacterium leprae but it has no impact on associated disability due to nerve function Impairment and trophic ulcer in leprosy. To explore the other means of treatment to save the leprosy patient from disability, a randomised double blind clinical trial was undertaken. Methodology: 160 leprosy patients who were released …

A Case Of Depressive Disorder & Tension Headache, Reeta Bagai, Manas R. Sarangi

Indian Journal of Research in Homoeopathy

Depression is a common as well as serious illness. Many people with a depressive illness never seek treatment. But the vast majority, even those with the most severe depression, can get better with treatment. Tension headache is the most common type of headache and is experienced at some time by the majority of the population in some form. Emotional strain or anxiety is a common precipitant to tension type headache and there is sometimes an underlying depressive illness. A case of tension headache with depressive disorder treated with Gelsemium is reported here.

Editorial, C. Nayak

Indian Journal of Research in Homoeopathy

The quote holds true because whenever we select a topic for research, in that particular area or subject, our knowledge is incomplete and problems are awaiting to be solved. We address the void in our knowledge and those unresolved problems by asking relevant questions and seeking answers to them. The role of research is to provide a method for obtaining those answers by studying the evidence within the parameters of the scientific method.

Program Langit Biru : Kontribusi Kebijakan Pengendalian Pencemaran Udara Kota Terhadap Penurunan Penyakit Pernapasan Pada Anak, Laila Fitria

Kesmas

Pencemaran udara perkotaan yang berdampak buruk terhadap kesehatan masyarakat sering dikaitkan dengan PM 10, NO2, dan ozon, polutan reaktif yang memicu kerusakan jaringan dalam saluran napas melalui mekanisme stres oksidatif dan inflamasi saluran napas. Pajanan jangka panjang polutan tersebut berpengaruh terhadap gangguan pernapasan, penurunan fungsi paru, asma, serta penyakit sistem pernapasan kronik lain seperti penyakit paru-paru obstruktif kronik. Program Langit Biru merupakan salah satu upaya mengurangi pencemaran udara dari sektor transportasi yang dicanangkan sejak tahun 1996. Hingga kini, kontribusi Program Langit Biru terhadap penurunan kasus gangguan pernapasan pada anak belum dapat diperkirakan, antara lain disebabkan oleh karena pelaksanaan program melalui …

Potret Kebijakan Pengendalian Demam Berdarah Dengue Di Kabupaten Indramayu, Henri Peranginangin, Hasim Hasim, Bambang Pramudya, Sri Budiarti

Kesmas

Penyakit demam berdarah dengue (DBD) masih menjadi masalah di Kabupaten Indramayu. Penelitian ini bertujuan mengidentifikasi elemen-elemen prioritas kebijakan pengendalian penyakit DBD di Kabupaten Indramayu menurut pakar berdasarkan metode Analytical Hierarchy Process (AHP). Hasil penelitian menunjukkan “strategi utama” pengendalian penyakit DBD di Kabupaten Indramayu adalah peningkatan kesehatan lingkungan permukiman; “aktor utama pengendalian” ialah Pemerintah Kabupaten Indramayu; “faktor utama pengendalian” adalah lingkungan; “tujuan utama pengendalian” ialah Kabupaten Indramayu bebas penyakit DBD; dan “kriteria utama pengendalian” adalah jumlah dan mutu sumber daya manusia. Agar implementasi strategi pengendalian itu efektif maka Pemerintah Kabupaten Indramayu perlu meningkatkan kerja sama lintas program dan sektoral; dukungan teknologi, …

Kesehatan Jiwa Yang Terabaikan Dari Target Milenium, Sri Idaiani

Kesmas

Millenium Development Goals (MDG) yang dicanangkan pada tahun 2000 sangat didominasi oleh penyakit menular serta kesehatan ibu dan anak, tetapi mengabaikan berbagai masalah penyakit tidak menular. Tidak sedikitpun terlintas dalam benak para pemimpin dunia itu target dan indikator yang menyentuh atau berhubungan dengan masalah kesehatan jiwa. Tulisan ini bertujuan membahas posisi kesehatan jiwa di seluruh dunia yang cenderung semakin memprihatinkan, tetapi justru terabaikan dari target MDG. Pencapaian target milenium tampaknya tidak memperhitungkan beban penyakit akibat berbagai masalah kejiwaan. Padahal, jika dibiarkan, pada masa mendatang masalah kesehatan jiwa akan menjadi besar seperti yang tengah dihadapi oleh berbagai negara maju. Berdasarkan prediksi …

Model Mitigasi Kebakaran Berbasis Masyarakat : Kajian Kualitatif Pada Aparat Pemerintah Dan Lsm, Fatmah Fatmah

Kesmas

Lingkungan masyarakat kota yang bebas kebakaran dapat tercipta melalui upaya pencegahan dan pemadaman kebakaran dini. Penelitian ini bertujuan mengembangkan model mitigasi kesiapsiagaan kebakaran berbasis masyarakat. Metoda kualitatif wawancara mendalam dilakukan terhadap 30 informan terpilih di Jabodetabek meliputi aparat kecamatan, kelurahan, Lembaga Swadaya Masyarakat, dan Suku Dinas Pemadam Kebakaran. Mayoritas informan mengenal organisasi Barisan Sukarelawan Kebakaran, tetapi dalam pelaksanaan ditemukan beberapa kendala antara lain meliputi tidak ada honorarium, status pekerjaan, dan anggota penduduk musiman. Hal tersebut berakibat banyak anggota yang berhenti dan sulit merekrut anggota baru. Bentuk upaya pencegahan kebakaran yang dilakukan masyarakat meliputi simulasi, penyuluhan, dan pelatihan bahaya kebakaran, serta …

Chylomicrons Promote Intestinal Absorption And Systemic Dissemination Of Dietary Antigen (Ovalbumin) In Mice, Yuehui Wang, Sarbani Ghoshal, Martin Ward, Willem De Villiers, Jerold Woodward, Erik Eckhardt

Internal Medicine Faculty Publications

BACKGROUND: A small fraction of dietary protein survives enzymatic degradation and is absorbed in potentially antigenic form. This can trigger inflammatory responses in patients with celiac disease or food allergies, but typically induces systemic immunological tolerance (oral tolerance). At present it is not clear how dietary antigens are absorbed. Most food staples, including those with common antigens such as peanuts, eggs, and milk, contain long-chain triglycerides (LCT), which stimulate mesenteric lymph flux and postprandial transport of chylomicrons through mesenteric lymph nodes (MLN) and blood. Most dietary antigens, like ovalbumin (OVA), are emulsifiers, predicting affinity for chylomicrons. We hypothesized that chylomicron …

Today - December 23, 2009, Loma Linda University

TODAY

Inside this issue:

-- Heart patient reunites with LLU Overseas Heart Surgery Team members 35 years after they saved her life in Saigon
-- CAPS welcomes Helping Hands Pantry to SACHS–Norton
-- Nursing professors research diabetes management in local community
-- LLU Heart & Surgical Hospital physician performs groundbreaking procedure
-- School of Public Health advances health geoinformatics education
-- Wyatt Caley raises funds to buy an Xbox 360 Elite for kids in Children’s Hospital
-- Milton Murray passes away
-- Trees of Hope bring beauty to Children’s Hospital lobby
-- LLU physician to appear on ‘The Doctors’
-- How …

Guyon's Canal Syndrome Due To Tortuous Ulnar Artery With Dequervain Stenosing Tenosynovitis, Ligamentous Injuries And Dorsal Intercalated Segmental Instability Syndrome, A Rare Presentation: A Case Report., Muhammad Zeeshan, Farhan Ahmed, Darakhshan Kanwal, Qazi Saad Bin Khalid, Muhammad Nadeem Ahmed

Department of Radiology

The Guyon's canal syndrome is a well known clinical entity and may have significant impact on Patient's quality of life. We report a case of 43-year-old male who presented with complaints of pain and numbness in right hand and difficulty in writing for past one month. On imaging diagnosis of Guyon's canal syndrome because of tortuous ulnar artery was made with additional findings of DeQuervain's stenosing tenosynovitis and dorsal intercalated segmental instability syndrome with ligamentous injury and subsequently these were confirmed on surgery. Although it is a rare syndrome, early diagnosis and treatment prevents permanent neurological deficits and improve Patient's …

Gbdr Regulates Pseudomonas Aeruginosa Plch And Pchp Transcription In Response To Choline Catabolites, Matthew J. Wargo, Tiffany C. Ho, Maegan J. Gross, Laurie A. Whittaker, Deborah A. Hogan

Dartmouth Scholarship

Pseudomonas aeruginosa hemolytic phospholipase C, PlcH, can degrade phosphatidylcholine (PC) and sphingomyelin in eukaryotic cell membranes and extracellular PC in lung surfactant. Numerous studies implicate PlcH in P. aeruginosa virulence. The phosphorylcholine released by PlcH activity on phospholipids is hydrolyzed by a periplasmic phosphorylcholine phosphatase, PchP. Both plcH gene expression and PchP enzyme activity are positively regulated by phosphorylcholine degradation products, including glycine betaine. Here we report that the induction of plcH and pchP transcription by glycine betaine is mediated by GbdR, an AraC family transcription factor. Mutants that lack gbdR are unable to induce plcH and pchP in media …

Party Favors For Sports: Strong Usoc, Spectacular World Cup, Rick Burton, Norm O'Relly

Sport Management - All Scholarship

No abstract provided.

The Relationship Between Post Reach Exit Exam (E2) Failure Remediation And Nclex-Rn Success Of Graduates Of Baccalaureate Nursing Programs, Patricia Gale Allen

Student Theses and Dissertations

An ex post facto study was conducted to determine whether any relationship exists between remediation post Reach Exit Exam (E2) failure and NCLEX-RN success of graduates of baccalaureate nursing programs. Data was gathered from responses to the seventh annual validity study (V7S) offered to deans and directors of nursing programs by the Director of Research for Elsevier, Incorporated. Data focused on test groups which received administration of the E2 between September 1, 2006 and August 31, 2007. Responses from 28 baccalaureate nursing programs were included in the study. After considering each program offering of either version one, version two or …

Germinal Center Reutilization By Newly Activated B Cells., Tanja A Schwickert, Boris Alabyev, Tim Manser, Michel C Nussenzweig

Department of Microbiology and Immunology Faculty Papers

Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude …