Medicine and Health Sciences Commons^™

Effect Of Donor Ethnicity On Kidney Survival In Different Recipient Pairs: An Analysis Of The Optn/Unos Database., C O. Callender, W S. Cherikh, P Traverso, A Hernandez, Tolulope A. Oyetunji, D Chang

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Previous multivariate analysis performed between April 1, 1994, and December 31, 2000 from the Organ Procurement Transplant Network/United Network for Organ Sharing (OPTN/UNOS) database has shown that kidneys from black donors were associated with lower graft survival. We compared graft and patient survival of different kidney donor-to-recipient ethnic combinations to see if this result still holds on a recent cohort of US kidney transplants.

METHODS: We included 72,495 recipients of deceased and living donor kidney alone transplants from 2001 to 2005. A multivariate Cox regression method was used to analyze the effect of donor-recipient ethnicity on graft and patient …

Dental Treatment Under General Anesthesia In Healthy And Medically Compromised/Developmentally Disabled Children: A Comparative Study, Juan Pablo Loyola-Rodriguez, Veronica Zavala-Alonso, Cinthya L. Gonzalez-Alvarez, Lilia A. Juarez-Lopez, Nuria Patiño-Marin, Cesar D. Gonzalez

School of Dentistry Faculty Research and Publications

Aim: To compare the type, number of procedures and working time of dental treatment provided under dental general anesthesia (DGA) in healthy and medically compromised/developmentally disabled children (MCDD children). Design: This cross-sectional prospective study involved 80 children divided into two groups of 40 children each. Group 1 consisted of healthy and Group 2 consisted of MCDD children. Results: Healthy children needed more working time than MCDD children, the means being 161±7.9 and 84±5.7 minutes, respectively (P= 0.0001). Operative dentistry and endodontic treatments showed a significant statistical difference (P= 0.0001). The means of procedures were 17±5.0 for healthy children and 11±4.8 …

Mindfulness Meditation And Art Making: Implications For Art Therapy, Susan Kathleen Mahl

EVMS School of Health Professions Theses & Dissertations

Meditation is being integrated into various fields to aid with healing, especially mindfulness meditation as it focuses on total awareness of the present. This thesis describes a self study that used a heuristic methodology to investigate the effects of mindfulness meditation on this researcher. I progressed through the six phases of heuristic research in a period seven weeks. At the beginning of the study, mindfulness meditation was practiced twice a week for a time period of 30 minutes to one hour for three weeks, followed by art making and reflections. Next, I practiced mindfulness meditation three times a week for …

The Differences In Levels Of Job Satisfaction Burnout And Self-Efficacy Between Correctional And Community Psychologists: The Effect Of Personality And Work Environment, Allison M. Herlickson

Theses and Dissertations

The purpose of the current study was to expand on research regarding levels of job satisfaction, burnout, and counselor self-efficacy within the field of psychology and particularly among correctional and community psychologists; explore the differences between correctional and community psychologists specifically in relation to levels job satisfaction, burnout, and self-efficacy; and examine difference and/or similarities in work environments and personality traits of correctional psychologists and community psychologists. The instruments used to measure job satisfaction, burnout, counselor self-efficacy, work environment, and personality were the Minnesota Satisfaction Questionnaire, Maslach Burnout Inventory, Counselor Self-Estimate Inventory, Work Environment Scale-10, and the International Personality Item …

Assessment Of Internationalised Domain Name Homograph Attack Mitigation, Peter Hannay, Christopher Bolan

Australian Information Security Management Conference

With the advent of internationalised domains the threat posed by non-english character sets has eventuated. Whilst this phenomenon remains well known in the development and internet industry the actual implementations of popular applications have been tested to determine their resilience to homograph based attack. The research found that most provided features that overcome such attacks, but there remain a few notable exceptions. Should an attacker take advantage of such oversights a victim would likely not be able to spot a fraudulent site or email and thus provide a perfect platform for subsequent attack.

A Pilot Study Of Organizational Performance, Performance Barriers And Faculty Engagement In The Nursing Education Unit, Yolanda Chapman Turner

Dissertations

This pilot study was driven by the problem of market disequilibrium and the subsequent overarching desire to identify and describe principles and processes taken by nursing education units to optimize market equilibrium for nursing service in response to cyclical market demands. Given the complexities of market responsiveness in conjunction with changes in healthcare delivery, health economics, population demographics, higher education and other contextual factors, it is essential for nursing education as a whole to be in a position to respond to demand. The purpose of this study was to investigate organizational performance, performance barriers and faculty engagement in the nursing …

Il-4(-/-) Mice With Lethal Mesocestoides Corti Infections--Reduced Th2 Cytokines And Alternatively Activated Macrophages., A. E. O'Connell, L. A. Kerepesi, G. L. Vandergrift, D. R. Herbert, T J. Van Winkle, D. C. Hooper, E J. Pearce, D. Abraham

Department of Microbiology and Immunology Faculty Papers

Protection against Mesocestoides corti, a cestode that invades vital organs, is dependent on the production of IL-4, as IL-4(-/-) mice were found to have higher parasite burdens when compared with wild-type mice. The goal of this study was to investigate the role of IL-4 in immunity to M. corti, focusing on the immunological profile and on potential mediators of pathology. IL-4(-/-) mice infected with M. corti showed 100% mortality by 32 days, whereas wild-type mice survived for approximately 1 year. Parasite burdens were significantly increased in the liver, peritoneal, and thoracic cavities of IL-4(-/-) mice, associated with impaired recruitment of …

Inactivation Of The Fliy Gene Encoding A Flagellar Motor Switch Protein Attenuates Mobility And Virulence Of Leptospira Interrogans Strain Lai, Sumei Liao, Ai-Hua Sun, David M. Ojcius, Senlin Wu, Jinfang Zhao, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Background: Pathogenic Leptospira species cause leptospirosis, a zoonotic disease of global importance. The spirochete displays active rotative mobility which may contribute to invasion and diffusion of the pathogen in hosts. FliY is a flagellar motor switch protein that controls flagellar motor direction in other microbes, but its role in Leptospira, and paricularly in pathogenicity remains unknown.

Results: A suicide plasmid for the fliY gene of Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai strain Lai that was disrupted by inserting the ampicillin resistance gene (bla) was constructed, and the inactivation of fliY gene in a mutant (fliY-) was confirmed by PCR and …

Fdg Pet-Positive, Mri-Negative Patients With Temporal Lobe Epilepsy: Etiology And Outcomes Compared To Patients With Hippocampal Sclerosis, C. Lopinto Khoury, M. Sperling, C. Skidmore, M. Nei, A. Zangaladze, J. Evans, A. Sharan, S. Mintzer

Department of Neurology Faculty Papers

FDG PET hypometabolism is important for surgical planning in patients with temporal lobe epilepsy (TLE), but its significance remains unclear in patients who do not have evidence of Hippocampal Sclerosis (HS) on MRI.

Improved Inter-Rater Reliability For Sah Ct Grading Scales Through Application Of A Formal Definition Of Clot Thickness, William Mcbride, Md, Valerie Dechant, Md, Michael Moussouttas, Md

Department of Neurology Faculty Papers

Various scales have been devised for the prediction of vasospasm following aneurysmal rupture.

Especially prominent in these scales is their reliance upon a subjective assessment of clot thickness which introduces variability in grading across raters.

The current study seeks to compare the inter-rater reliability of the traditional Fisher and newer "Frontera" scale (Modified Fisher) when a rigid definition of thick clot is employed.

No Association Of Obesity And Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer, Cheryl L. Thompson, Sarah J. Plummer, Thomas C. Tucker, Graham Casey, Li Li

Markey Cancer Center Faculty Publications

Background: Obesity and type 2 diabetes mellitus (T2D) are known risk factors for colon cancer. Recent reports from a number of genome wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with obesity and T2D. Here we tested the hypothesis that these SNPs may also be associated with risk of colon cancer.

Methods: We genotyped nine SNPs reported in GWAS of obesity and/or T2D, including SNPs in HHEX, KCNJ11, SLC30A8, FTO, CDKN2, CDKAL1, TCF2, and the rs9300039 SNP in an intergenic region, in 561 colon cancer cases and 721 population controls.

Results: None of these SNPs were …

Discovery And Validation Of New Regulatory Rna Elements In Chlamydia Trachomatis, Yasser Mohammed Elsayed Metwally Abdelrahman

Theses and Dissertations (ETD)

Chlamydia trachomatis is an obligate intracellular bacterium that exhibits a unique biphasic developmental cycle that can be disrupted by growth in the presence of IFN-g and b-lactams, giving rise to an abnormal growth state termed persistence. Relatively little is known about the regulatory mechanisms that control temporal gene expression during the developmental cycle or the control of persistence and reactivation. Here we have examined the expression of a newly defined family of non-coding RNAs (ncRNAs) that are differentially expressed during the developmental cycle and the induction of persistence and reactivation (Using IFNγ and Carbenicillin). Non-coding RNAs were initially identified using …

Function And Pain In Community-Dwelling, Adult Mid-Southerners With Limb Loss, Cecile B. Evans

Theses and Dissertations (ETD)

Background: Limb loss affects about 1 in 190 people in the US. Risk factors for limb loss include diabetes, obesity, smoking, minority race, and poverty, which are all common in the Mid-South population. Function is impaired by limb loss, and pain associated with limb loss may further impair function.

Purpose: Describe the function, pain, health status, and demographics of community-dwelling, adult Mid-Southerners with limb loss. Estimate the relationship between function and pain, health status, and demographics of community-dwelling, adult Mid-Southerners with limb loss. Estimate the joint influences on function by pain, health status, and demographics of community-dwelling, adult Mid-Southerners with …

Preferences And Willingness To Pay For Osteoarthritis Treatments Among The Medicare Population, Meghan Alexis Hufstader

Theses and Dissertations (ETD)

The design of this study is a non-random cross sectional survey to determine Medicare beneficiaries’ preferences and willingness to pay for osteoarthritis (OA) treatments. The population of interest in this study is the Medicare eligible (over age 65) population in Memphis, TN, and surrounding cities. Data were collected at Senior Centers and one internal medicine practice. The sample size was 181.

Choice-based conjoint analysis technique was utilized. The preferences and willingness to pay were determined using choice-based conjoint analysis, advanced design module with a dual-response none option. Choice-based conjoint analysis uses computer guided surveys to elicit patient preference for a …

Chitosan/Ellagic Acid Composite Materials For Local Cancer Therapy, Sung Woo Kim

Theses and Dissertations (ETD)

Current advances in the drug delivery have improved the therapeutic efficacy of the drug and minimized risks of side effects associated with toxicity of the drug. Implantable polymeric delivery system has gained increasing attentions for controlled drug release and localized treatments. In comparison to conventional chemotherapy, polymeric delivery systems are implantable at a local targeted site and biodegradable after a sufficient therapeutic span. The objectives of this project were to fabricate and characterize an implantable polymeric vehicle for a local chemotherapy and investigate its biological properties against cancer cells including human WM115 melanoma, human U87 glioblastoma, and rat C6 glioma …

Identification Of The Downstream Effector Genes Involved In Hoxb4-Induced Expansion Of Hematopoietic Progenitor Cells, Jie Jiang

Theses and Dissertations (ETD)

Overexpression of HOXB4, a member of Homeobox transcription factor family, promotes expansion of hematopoietic stem and progenitor cells bothin vivo and in vitro. However, the molecular mechanisms underlying this effect are not well understood. In order to identify direct target genes of HOXB4 in primary murine hematopoietice progenitor cells, we induced HOXB4 function in lineage-negative, murine bone marrow cells, using a tamoxifen-inducibleHOXB4-ER^T2fusion protein. Seventy seven genes with differentially changed expression in early response to HOXB4 have been identified as candidate target genes. Among them, we show that Hemogen (Hemgn), encoding a nuclear protein specifically …

Contribution Of The Membrane-Proximal Region Of The Vesicular Stomatitis Virus Glycoprotein To Host Cell Entry And Membrane Fusion, Elizabeth Lane Matheny

Theses and Dissertations (ETD)

Vesicular stomatitis virus (VSV) is an enveloped, nonsegmented, negative-sense, RNA virus belonging to the Rhabdoviridae family. VSV is considered the prototypic Rhabdovirus due to its simple genetic organization, broad host cell tropism, and ability to be easily grown in cell culture. Therefore, VSV has been used as the prototype to study viral entry, transcription, replication, and assembly. Viral entry, a critical step in the lifecycle of the virus, is mediated by the outer surface protein, G and will be the focus of this dissertation.

We hypothesize that the highly conserved residues in the membrane-proximal region of VSV G protein are …

Physical And Functional Coupling Of Cftr And Pde3a, Himabindu Penmatsa

Theses and Dissertations (ETD)

Formation of multiple-protein macromolecular complexes at specialized subcellular microdomains increases the specificity and efficiency of signaling in cells. In this study, we demonstrated that phosphodiesterase type 3A (PDE3A) is physically and functionally coupled to cystic fibrosis transmembrane conductance regulator (CFTR). PDE3A inhibition increases cyclic adenosine 3′, 5′-monophosphate (cAMP) levels in a compartmentalized manner at the plasma membrane, which potentiates CFTR channel function and further clusters PDE3A and CFTR into microdomains. Actin skeleton disruption reduces PDE3A-CFTR interaction; segregates PDE3A from its interacting partners thus compromise the integrity of the macromolecular complex. Consequently, PDE3A inhibition no longer activates CFTR channel function in …

Pandemic Potential Of Reassortant Swine Influenza A Viruses, Christy Brockwell Staats

Theses and Dissertations (ETD)

Influenza A viruses are capable of causing disease in several species, including birds, humans and swine. Host specificity of the viruses is not absolute, and is influenced by a range of factors. Swine play a pivotal role in the interspecies transmission of influenza A viruses, as they are susceptible to infection with both human and avian strains and have been implicated as a “mixing vessel” for the reassortment of influenza A viruses from different species. The reassortment of influenza A viruses of human and avian origin led to human influenza pandemics in 1957 and 1968.

The dynamics of swine influenza …

Efficacy Of Various Strains Of Infectious Bronchitis Vaccine Against Nephropathogenic Infectious Bronchitis Virus Isolated From Chickens In Thailand, Tawatchai Pohuang, Kanlaya Chuachan, Niwat Chansiripornchai, Jiroj Sasipreeyajan

The Thai Journal of Veterinary Medicine

One hundred, 1 week old, female broiler chickens were divided into 5 groups, 20 chickens in each. Each group was vaccinated with a different strain of infectious bronchitis vaccine; Ma5, H120 and a local strain produced by the Department of Livestock Development for groups 3, 4 and 5, respectively. All the vaccinated chickens received intraocular vaccine at 1 week old. The chickens in groups 1 and 2 served as a negative control and a positive control group, respectively. All the chickens were weighed at 1, 4 and 6 weeks old and challenged at 4 weeks old with nephropathogenic infectious bronchitis …

Detection Of Antibody Titer Against Toxoplasma Gondii In Aborted Sows And Gilts In A Swine Herd In Thailand, Padet Tummaruk, Woraporn Sukhumavasi, Sasiwimon Talummuk, Annop Kunavongkrit

The Thai Journal of Veterinary Medicine

No abstract provided.

The Efficacy Of Escherichia Coli Aroa-Live Vaccine In Broilers Against Avian E. Coli Serotype O78 Infection, Visut Rawiwet, Niwat Chansiripornchai

The Thai Journal of Veterinary Medicine

The efficacy of an Escherichia coli (E. coli) aroA-live vaccine in the prevention of colibacillosis in chickens following intratracheal challenge with a virulent strain of E. coli O78 was investigated. Thirty-six, one day old broiler chickens were divided into 3 groups of 12 each. Chickens in each group were randomly divided into 2 replicates. The chickens in group 1 that were not vaccinated and challenged served as a negative control. The chickens in group 2 that were not vaccinated but received E. coli serotype O78 served as a positive control. The chickens in group 3 were vaccinated by the oral …

Proceeding Of The 4th Asian Society Of Veterinary Pathologists (Asvp) Conference And Annual Meeting Of The Thai Association Of Veterinary Laboratory Diagnosticians (Tavld) -1, Achariya Sailasuta

The Thai Journal of Veterinary Medicine

No abstract provided.

Fluorescent Protein Markers To Tag Collagenous Proteins: The Paradigm Of Procollagen Vii, Hye J. Chung, Andrzej Steplewski, Jouni Uitto, Andrzej Fertala

Department of Dermatology and Cutaneous Biology Faculty Papers

Fluorescent proteins are powerful markers allowing tracking expression, intracellular localization, and translocation of tagged proteins but their effects on the structure and assembly of complex extracellular matrix proteins has not been investigated. Here, we analyzed the utility of fluorescent proteins as markers for procollagen VII, a triple-helical protein critical for the integrity of dermal-epidermal junction. DNA constructs encoding a red fluorescent protein-tagged wild type mini-procollagen VII α chain and green fluorescent protein-tagged α chains harboring selected mutations were genetically engineered. These DNA constructs were co-expressed in HEK-293 cells and the assembly of heterogeneous triple-helical mini-procollagen VII molecules was analyzed. Immunoprecipitation …

Chronic Subjective Dizziness (Csd) Vs. Conversion Disorder: Discussion Of Clinical Findings And Rehabilitation., Julie A. Honaker, Jane M. Gilbert, Jeffrey P. Staab

Department of Special Education and Communication Disorders: Faculty Publications

PURPOSE: Audiologists frequently encounter patients who complain of chronic dizziness or imbalance, in the absence of active vestibular or neurological deficits. Knowledge about conditions that cause this clinical presentation will allow audiologists to make important contributions to accurate diagnosis and effective management of these patients. This article reviews two such conditions, chronic subjective dizziness (CSD) and conversion disorder. METHOD: A case of CSD and another of conversion disorder are presented with a literature review of their clinical presentations, key diagnostic features, and treatment strategies. The role of the audiologist in assessing patients with these conditions and facilitating appropriate treatment referrals …

Challenges In Improving Information Security Practice In Australian General Practice, Donald C. Mcdermid, Rachel J. Mahncke, Patricia A. Williams

Australian Information Security Management Conference

The status of information security in Australian medical general practice is discussed together with a review of the challenges facing small practices that often lack the technical knowledge and skill to secure patient information by themselves. It is proposed that an information security governance framework is required to assist practices in identifying weaknesses and gaps and then to plan and implement how to overcome their shortcomings through policies, training and changes to processes and management structure.

Measuring Information Security Governance Within General Medical Practice, Rachel J. Mahncke, Donald C. Mcdermid, Patricia A. Williams

Australian Information Security Management Conference

Information security is becoming increasingly important within the Australian general medical practice environment as legal and accreditation compliance is being enforced. Using a literature review, approaches to measuring information security governance were analysed for their potential suitability and use within General Practice for the effective protection of confidential information. The models, frameworks and guidelines selected were analysed to evaluate if they were Key Performance Indicator (KPI), or process driven; whether the approach taken was strategic, tactical or operational; and if governance or management assessment tools were presented. To measure information security governance, and be both effective and practical, the approach …

The Relationship Between Residency And Socio-Demographics To Academic Performance In Ncaa Division I Freshman Athletes, Eric Matthew Snyder

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Numerous studies have been completed on the academic ability of student athletes. Since the mid 1980s, the NCAA has emphasized the importance of academics and mandated more stringent requirements to be able to participate in intercollegiate athletics. These initial-eligibility standards have been successful in increasing overall graduation rates of student-athletes, but there remain a number of concerns. The purpose of the study was to determine if an NCAA D-I freshman student athlete's place of residency on campus, as opposed to off campus, while attending college during his/her freshman year had a statistically significant relationship to achievement as it relates to …

The Relationship Between Quality Of Maternal Care And The Development Of Infant Sociability In A Captive Group Of Western Lowland Gorillas, Liza Veliz

Theses and Dissertations - UTB/UTPA

Maternal factors, e.g., quality and behavior were examined in order to determine if a relationship with enhanced infant social development exists. Gorilla mothers were each nursery reared and are full siblings, providing an unusual opportunity to examine the individual differences that may play a role in infant socialization. Observational data collected during three-time blocks by means of focal animal sampling were used to analyze social behaviors and identify initiators and receivers of contact behaviors, thereby determining a relationship between maternal care and infant sociability. Results indicated that mothers who provided successful maternal care produced more sociable offspring. Findings from this …

Curanderismo And Healing Rituals: An Ethnographic And Historical Study Of The Casma Valley In Northern Peru, Maria Esmeralda Perez

Theses and Dissertations - UTB/UTPA

While curanderismo and shamanism form an important cultural aspect throughout Peru, the healing rituals in the Casma Valley are mostly unknown. This paper attempts to define the historical background of curanderismo in the Casma Valley by describing the traditional healing rituals throughout the Atlantic World. Recounting, not only the history of curanderismo, religion, witchcraft, and sorcery in Latin America, but also the history of these beliefs in Europe and Africa as well. One of the main goals of this paper is to provide sufficient proof of the ties and connections that curanderismo in the Casma Valley in Northern Peru share, …