Medicine and Health Sciences Commons^™

Cirsoid Aneurysm With Impending Rupture, Amit Agrawal

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Bilateral Cerebellar Stroke With Good Functional Recovery, Maimoona Siddiqui, Farrukh Shohab Khan, Mohammad Salman

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

การพัฒนาแบบสอบถามออนไลน์สำหรับการวิจัย ทางพฤติกรรมการเรียนรู้ไอทีทางการแพทย์, โชคชัย เปลี่ยนไพโรจน์

Chulalongkorn Medical Journal

No abstract provided.

การจัดยาสำรองบนหอผู้ป่วยโดยการสรุปรวมใบสั่งยา เปรียบเทียบกับการจัดยาทีละใบสั่งยา, นิสา เลาหพจนารถ, เพ็ญประภา ตั้งวันเจริญ

Chulalongkorn Medical Journal

No abstract provided.

Improving Outcome In Pediatric Intensive Care Unit In Academic Hospital In Pakistan, Anwarul Haque, Surraiya Bano

Department of Emergency Medicine

Objective:

To assess the impact on the clinical outcome of critically ill children before and after introduction of pediatric intensivist in an academic pediatric intensive care unit (PICU) inPakistan.

Methodology: :

This is aretrospective audit of children (age from one month to 14 years) admitted in the PICU during two 12-month periods in PICU of Aga Khan University Hospital (AKUH).Patients in Cohort one were managed by pediatric intensivist while in Cohort two were managed by general pediatricians.Patients were compared during the two 12-month cohort period.

Results:

During the study, in cohort one, 314 patients were admitted, mean age was 24 …

Work Hard So No Rest, Is It True?, S. Hengphraphorm

Chulalongkorn Medical Journal

No abstract provided.

Workplace Health Promotion Projects And Activities In Government Organizations In Thailand: A Qualitative Research, P. Sithisarankul, P. Isarabhakdi, S. Muanlamai, W. Modmoltin, T. Panprom

Chulalongkorn Medical Journal

No abstract provided.

สุขภาพจิตของนักเรียนมัธยมศึกษาตอนปลาย: กรณีศึกษาในโรงเรียนสังกัดสำนักงานเขตพื้นที่การศึกษาเขต 1 กรุงเทพมหานคร, นัยนา เอื้อพงศ์กิติกุล, ศิริลักษณ์ ศุภปีติพร

Chulalongkorn Medical Journal

No abstract provided.

Neuropsychological Effects Of The Traumatic Stress Response In Sexually Abused Adolescents Throughout Treatment, Kathryn R. Wilson

Department of Psychology: Dissertations, Theses, and Student Research

Child maltreatment is a pervasive problem in our society that has long-term detrimental consequences to the development of the affected child such as future brain growth and functioning. The alteration of the biochemical stress response system in the brain that changes an individual’s ability to respond efficiently and efficaciously to future stressors is conceptualized as the traumatic stress response. The purpose of this research was to explore the effects of the traumatic stress response on sexually abused adolescents’ through a two-tiered study of neuropsychological functioning throughout treatment. It was determined that there are measurable differences in neuropsychological processing in sexually …

A Comparison Of Two Theoretical Models Of Procedural Justice In The Context Of Child Protection Proceedings, Twila Wingrove

Department of Psychology: Dissertations, Theses, and Student Research

In this study, the researcher tested two theoretical models of justice in the context of child protection proceedings. Participants read a case file describing a hypothetical child neglect case. The file included the court petition, the caseworker’s court report, a summary of the protective custody hearing, and the judge’s final order. Within the case file, the researcher manipulated four variables: procedural treatment, interpersonal treatment, severity of child neglect, and assigned role (judge or parent). Results of confirmatory factor analyses suggested that a four-factor model of justice judgments best fit the data. Consistent with the organizational justice approach (Colquitt, 2001) the …

Growing Ambulatory Care Nurse Leaders: Building Talent From The Primed Pipeline, Beth A. Swan, Janet P. Moye

College of Nursing Faculty Papers & Presentations

In this article, the first of two on this topic, the importance of leadership and succession planning will be defined, desired leadership competencies identified, different opportunities and approaches for succession planning identified, and organizational strategies identified, as well as personal strategies, that may be employed for leadership succession planning. In the second article, in an upcoming issue of Nursing Economic$, the role played by multiple generations in building talent and leadership succession planning will be described.

Dicer Is Required For Female Reproductive Tract Development And Fertility In The Mouse, Gabriel Gonzalez, Richard R Behringer

Faculty, Staff and Student Publications

Dicer encodes a riboendonuclease required for microRNA biosynthesis. Dicer was inactivated in Müllerian duct mesenchyme-derived tissues of the reproductive tract of the mouse, using an Amhr2-Cre allele. Although Amhr2-Cre; Dicer conditional mutant males appeared normal and were fertile, mutant females were infertile. In adult mutant females, there was a reduction in the size of the oviducts and uterine horns. The oviducts were less coiled compared to controls and cysts formed at the isthmus near the uterotubal junction. Unfertilized, degenerate oocytes were commonly found within these cysts, indicating a defect in embryo transit. Beads transferred into the mutant oviduct failed to …

Chronic Exposure To Arsenic In The Drinking Water Alters The Expression Of Immune Response Genes In Mouse Lung, Courtney D. Kozul, Thomas H. Hampton, Jennifer C. Davey, Julie A. Gosse, Athena P. Nomikos, Phillip L. Eisenhauer, Daniel J. Weiss, Jessica E. Thorpe, Michael A. Ihnat, Joshua W. Hamilton

Dartmouth Scholarship

Background:

Chronic exposure to drinking water arsenic is a significant worldwide environmental health concern. Exposure to As is associated with an increased risk of lung disease, which may make it a unique toxicant, because lung toxicity is usually associated with inhalation rather than ingestion.

Objectives:

The goal of this study was to examine mRNA and protein expression changes in the lungs of mice exposed chronically to environmentally relevant concentrations of As in the food or drinking water, specifically examining the hypothesis that As may preferentially affect gene and protein expression related to immune function as part of its mechanism of …

Persistent Nodular Rash In An Elderly Patient, Daniel Dejoseph, Md, James Studdiford, Md, Amber Stonehouse, Md, Beth Careyva, Md

Department of Family & Community Medicine Faculty Papers

A 62yo white male presented to same day clinic with an erythematous nodular rash. He was initially treated with antibiotics for a furunculosis, but the rash worsened and he was eventually found to have secondary syphilis. He is an MSM who had a prior history of syphilis, putting him at high risk for STI’s and HIV, and should have been undergoing annual screening. He was found to be HIV positive. The rates of STI’s and HIV are increasing in older Americans. Despite this, physicians do not regularly screen this population for unsafe sexual behavior. This case emphasizes the importance of …

Coupling Between The Voltage-Sensing And Phosphatase Domains Of Ci-Vsp, Carlos A. Villalba-Galea, Francesco Miceli, Maurizio Taglialatela, Francisco Bezanilla

School of Pharmacy Faculty Articles

The Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP) shares high homology with the phosphatidylinositol phosphatase enzyme known as PTEN (phosphatase and tensin homologue deleted on chromosome 10). We have taken advantage of the similarity between these proteins to inquire about the coupling between the voltage sensing and the phosphatase domains in Ci-VSP. Recently, it was shown that four basic residues (R11, K13, R14, and R15) in PTEN are critical for its binding onto the membrane, required for its catalytic activity. Ci-VSP has three of the basic residues of PTEN. Here, we show that when R253 and R254 (which are the homologues …

Vitamin B12 Deficiency--A Major Cause Of Megaloblastic Anaemia In Patients Attending A Tertiary Care Hospital, Saira Perwaiz Iqbal, Ghulam Nabi Kakepoto, Saleem Perwaiz Iqbal

Department of Pathology and Laboratory Medicine

BACKGROUND: Folate and vitamin B12 deficiencies have been known to cause megaloblastic anaemia. Since the deficiencies of these two vitamins are very common in Pakistani population, it would be imperative to investigate their role in causing megaloblastic anaemia. The objective of this study was to find out the contribution of folate and vitamin B12 deficiencies in causing megaloblastic anaemia in our patient population.

METHODS: In this retrospective cohort study, clinical records of 220 patients (101 females and 119 males with an age range of 1-80 years) who presented themselves with macrocytic anaemia at the Aga Khan University Hospital were collected. …

Soluble Adenylyl Cyclase-Dependent Microtubule Disassembly Reveals A Novel Mechanism Of Endothelial Cell Retraction, Nutan Prasain, Mikhail Alexeyev, Ron Balczon, Troy Stevens

University Faculty and Staff Publications

Soluble adenylyl cyclase toxins, such as Pseudomonas aeruginosa exoY, generate a cAMP pool that retracts cell borders. However, the cytoskeletal basis by which this cAMP signal retracts cell borders is not known. We sought to determine whether activation of chimeric, soluble adenylyl cyclase I/II (sACI/II) reorganizes either microtubules or peripheral actin. Endothelial cells were stably transfected with either green fluorescent protein-labeled alpha-tubulin or beta-actin, and then infected with adenovirus to express sACI/II. Forskolin, which stimulates both the endogenously expressed transmembrane adenylyl cyclases and sACI/II, induced cell retraction accompanied by the reorganization of peripheral microtubules. However, cortical filamentous-actin (f-actin) did not …

Native Cellular Architecture Of Treponema Denticola Revealed By Cryo-Electron Tomography, Jacques Izard, Chyong-Ere Hsieh, Ronald J. Limberger, Carmen A. Mannella, Michael Marko

Department of Food Science and Technology: Faculty Publications

Using cryo-electron tomography, we are developing a refined description of native cellular structures in the pathogenic spirochete Treponema denticola. Tightly organized bundles of periplasmic flagella were readily observed in intact plunge-frozen cells. The periplasmic space was measured in both wild-type and aflagellate strains, and found to widen by less than the diameter of flagella when the latter are present. This suggests that a structural change occurs in the peptidoglycan layer to accommodate the presence of the flagella. In dividing cells, the flagellar filaments were found to bridge the cytoplasmic cylinder constriction site. Cytoplasmic filaments, adjacent to the inner membrane, …

Carbohydrate Intake And Overweight And Obesity Among Healthy Adults, Anwar T. Merchant, Hassanali Vatanparast, Shahzaib Barlas, Mahshid Dehghan, Syed Mahboob Ali Shah, Lawrence De Koning, Susan E. Steck

Faculty Publications

Background - Little is known about the dietary habits of people with optimal body weight in communities with high overweight and obesity prevalence.

Objective - To evaluate carbohydrate intake in relation to overweight and obesity in healthy, free-living adults

Design - We used a cross-sectional analysis

Subjects/setting - The Canadian Community Health Survey Cycle 2.2 is a cross-sectional survey of Canadians conducted in 2004-2005. There were 4,451 participants aged 18 years and older with anthropometric and dietary data and no comorbid conditions in this analysis.

Main outcome measures - Outcome variables were body mass index (BMI; calculated as kg/m^{2 …}

Reasons Why Women Do Not Initiate Breastfeeding: A Southeastern State Study, Chinelo A. Ogbuanu, Janice C. Probst, Sarah B. Laditka, Jihong Liu, Jongdeuk Baek, Saundra Glover

Faculty Publications

Purpose - Despite the increase in breastfeeding initiation and duration in the United States, only five states have met the three Healthy People 2010 breastfeeding objectives. Our objectives are to study women's self-reported reasons for not initiating breastfeeding and to determine whether these reasons vary by race/ethnicity, and other maternal and hospital support characteristics.

Methods - Data are from the 2000-2003 Arkansas Pregnancy Risk Assessment Monitoring System, restricting the sample to women who did not initiate breastfeeding (unweighted n = 2,917). Reasons for not initiating breastfeeding are characterized as individual reasons, household responsibilities, and circumstances. Analyses include the χ^{2 …}

Predictors And Outcomes Of Postpartum Mothers' Perceptions Of Readiness For Discharge After Birth, Marianne E. Weiss, Lisa Lokken

College of Nursing Faculty Research and Publications

Objective: To identify predictors and outcomes of postpartum mothers' perceptions of their readiness for hospital discharge. Design: A correlational design with path analyses was used to explore predictive relationships among transition theory-related variables. Setting: Midwestern tertiary perinatal center. Participants: One hundred and forty-one mixed-parity postpartum mothers who had experienced vaginal birth or Cesarean delivery of normal healthy infants. Methods: Before hospital discharge, patients completed questionnaires about sociodemographic characteristics, hospitalization factors, quality of discharge teaching, and readiness for discharge. Three weeks postdischarge, mothers were contacted by telephone to collect coping difficulty and health care utilization data. Main Outcome Measures: Readiness for …

Title: Student Readiness For Interprofessional Learning: Baseline And Midpoint In The Jefferson Health Mentor Program, Elena M. Umland, Cynthia A. Sanoski, Jon Veloski, Kevin Lyons, Carolyn Giordano, Christine Arenson, Molly Rose

College of Pharmacy Faculty Papers

Objectives: To measure pharmacy student readiness for interprofessional education (IPE) and compare the results to medical, nursing, occupational therapy (OT), and physical therapy (PT) student peers using the Readiness for Interprofessional Learning Scale (RIPLS).

Methods: First-year medical, nursing, OT, pharmacy, and PT students (n=544) participate in a 2-year longitudinal, interdisciplinary curriculum where they are assigned to a team including a Health Mentor (patient volunteer with chronic condition). Aims include understanding team roles and patient-centered care. All students complete the RIPLS at baseline and after completing years 1 and 2. RIPLS contains 3 subscales related to readiness for IPE: 1.)teamwork and …

The Catholic Physician And Natural Family Planning: Helping To Build A Culture Of Life, Richard J. Fehring

College of Nursing Faculty Research and Publications

This paper is based on the author's answer to a question from Theresa Notare, director of the Natural Family Planning Program of the U.S. Conference of Catholic Bishops, about what Catholic scientists and physicians can do to promote NFP and what the Catholic Church in the United States can do to help physicians and health professionals promote NFP. The paper reviews the Church's historical call for health professionals to study and to teach NFP methods, briefly analyzes the current state of NFP in Catholic health care, and provides an answer to Dr. Notare from the perspectives of research, education, and …

Lsuhsc Facilities Daily Update: July 2009, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2009

LSUHSC Dailly Facilities Updates from July 2009.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: July 2009, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2009

LSUHSC Facilities Biweekly Updates from July 3, 17 and 31, 2009.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Efficient Parameter Estimation In Longitudinal Data Analysis Using A Hybrid Gee Method, Denis H. Y. Leung, You Gan Wang, Min Zhu

Research Collection School Of Economics

The method of generalized estimating equations (GEEs) provides consistent estimates of the regression parameters in a marginal regression model for longitudinal data, even when the working correlation model is misspecified (Liang and Zeger, 1986). However, the efficiency of a GEE estimate can be seriously affected by the choice of the working correlation model. This study addresses this problem by proposing a hybrid method that combines multiple GEEs based on different working correlation models, using the empirical likelihood method (Qin and Lawless, 1994). Analyses show that this hybrid method is more efficient than a GEE using a misspecified working correlation model. …

Book Review Of Unspeakable: The Story Of Junius Wilson, Michael Ashley Stein, Aviam Soifer

Faculty Publications

No abstract provided.

Jefferson Alumni Bulletin – Volume 58, Number 2, Summer 2009

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 58, Number 2, Summer 2009

Dean’s Message, page 2

Findings, Biomaker Predicts Disease Recurrence in Colorectal Cancer, page 4

Service Lines: Guiding Patients Through the Maze, page 6

University’s Emphasis on Interdisciplinary Care Fuels Growth, page 12

Mütter Turns 150 with New Take on the Old, page 16

On Campus, page 18

Graduation 2009, page 22

Class Notes, page 24

In Memoriam, page 30

By The Numbers, page 33

Nerve Injection Of Viral Vectors Efficiently Transfers Transgenes Into Motor Neurons And Delivers Rnai Therapy Against Als., Rui Wu, Hongyan Wang, Xugang Xia, Hongxia Zhou, Chunyan Liu, Maria Castro, Zuoshang Xu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

RNA interference (RNAi) mediates sequence-specific gene silencing, which can be harnessed to silencing disease-causing genes for therapy. Particularly suitable diseases are those caused by dominant, gain-of-function type of gene mutations. In these diseases, the mutant gene generates a mutant protein or RNA product, which possesses toxic properties that harm cells. By silencing the mutant gene, the toxicity can be lessened because the amount of the toxic product is lowered in cells. In this report, we tested RNAi therapy in a mouse model for amyotrophic lateral sclerosis (ALS), which causes motor neuron degeneration, paralysis, and death. We used a transgenic model …

Prevalence Of Hepatitis D In Hbsag Positive Patients Visiting Liver Clinics, Naresh Kumar Seetlani, Zaigham Abbas, Sajjad Raza, Javed Yakoob, Wasim Jafri

Section of Gastroenterology

Objective: To estimate the prevalence of hepatitis D in HBsAg (hepatitis B surface antigen) positive patients visiting liver clinics.

Methodology: All HbsAg positive patients who had visited two liver clinics; in Karachi and in Jacobabad, from October 2007 to March 2008, were included in this study. These patients were tested for HBV DNA and HDV RNA by PCR technique, HBeAg and anti-HDV. Clinical status of the patients was evaluated by examination, routine biochemical tests and ultrasound.

Results: Total numbers of patients included in the study were 362 comprising of 151 patients from the clinic in Jacobabad and 211 from Karachi. …