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2006

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Articles 2041 - 2070 of 2765

Full-Text Articles in Medicine and Health Sciences

Understanding The Hiv/Sti Prevention Needs Of Men Who Have Sex With Men In Kenya, Washington Onyango-Ouma, Harriet Birungi, Scott Geibel Jan 2006

Understanding The Hiv/Sti Prevention Needs Of Men Who Have Sex With Men In Kenya, Washington Onyango-Ouma, Harriet Birungi, Scott Geibel

HIV and AIDS

Understanding the sexual behaviors of populations who are vulnerable to HIV is an important component in the battle against AIDS. Yet policymakers in developing countries, particularly in Africa, have often overlooked men who have sex with men (MSM) as a vulnerable group because of stigmatization of homosexual behavior and denial of the existence of MSM and the role they may play in HIV transmission. A growing body of literature not only documents the presence of this population in Africa but also the importance of reaching them with information and services to prevent HIV and other sexually transmitted infections (STIs). In …


The Role Of Prophylactic Intra-Aortic Balloon Pump Counterpulsation (Iabp) In Emergency Non-Cardiac Surgery, Khalid Samad, Fauzia Anis Khan Jan 2006

The Role Of Prophylactic Intra-Aortic Balloon Pump Counterpulsation (Iabp) In Emergency Non-Cardiac Surgery, Khalid Samad, Fauzia Anis Khan

Department of Anaesthesia

Patients with recent myocardial infarction (MI), congestive heart failure, severe angina, or uncorrected multivessel coronary artery disease are at increased risk of cardiac complications after urgent major non-cardiac surgery. Although invasive haemodynamic monitoring and preoperative optimization of cardiac status may lead to some reduction in the rate of perioperative cardiac events, the mortality from such events still remains high. The use of an intra-aortic balloon pump (IABP) may play a role in such patients by improving the function of the injured heart. We report our experience with the use of perioperative IABP in a patient with unstable angina and recent …


New Pelagic Gastropoda Species Encountered On The Turkish Coast Of The Levant Sea, Cem Çevi̇k, Ahmet Kideys, Beni̇n Toklu, Deni̇z Ergüden, Ercan Sarihan Jan 2006

New Pelagic Gastropoda Species Encountered On The Turkish Coast Of The Levant Sea, Cem Çevi̇k, Ahmet Kideys, Beni̇n Toklu, Deni̇z Ergüden, Ercan Sarihan

Turkish Journal of Veterinary & Animal Sciences

In this work, 9 species of pelagic gastropods were studied during bottom trawling and net sampling for zooplankton of Akkuyu in Erdemli and in İskenderun Bay (the northeastern Mediterranean). Among those, Pterotrachea hippocampus Phlippi, 1836, Cavolinia tridentate (Forsskal, 1775), Limacina (Munthea) trochiformis (D'Orbigny, 1836), and Corolla spectabilis (Dall, 1871) were first records for Turkish mollusk fauna, and the remaining, Atlanta peronii Lesuer, 1817, Firoloida desmarestia Lesuer, 1817, Clio pyramidata Linné, 1767, Creseis acicula Rang, 1828, and Creseis virgula Rang, 1828 were first records for the Mediterranean coast of Turkey.


Effects Of Double Injections Of Pgf_{2}\Alpha At Different Intervals On Some Reproductive Traits In Tuj Ewes, Nalan Bayşu Sözbi̇li̇r, Şaban Maraşli, Yavuz Öztürkler, Ömer Uçar Jan 2006

Effects Of Double Injections Of Pgf_{2}\Alpha At Different Intervals On Some Reproductive Traits In Tuj Ewes, Nalan Bayşu Sözbi̇li̇r, Şaban Maraşli, Yavuz Öztürkler, Ömer Uçar

Turkish Journal of Veterinary & Animal Sciences

The present study investigated the effects of double injections of PGF_{2}\alpha at different intervals (10 vs. 14 days) on plasma progesterone levels, oestrus and lambing rates in Tuj ewes during the breeding season. Thirty clinically healthy mature ewes were assigned randomly into 2 experimental groups: 2 injections of 125 µg of Cloprostenol (a PGF_{2}\alpha analogue) at either 10 (Group I, n = 15) or 14 day (Group II, n = 15) intervals. Blood samples were collected from the jugular vein on the day of the second injection of PGF_{2}\alpha, 4 days post-injection and 16 days after insemination to determine plasma …


Effects Of Feeding Frequency On Growth, Feed Consumption, And Body Composition In Juvenile Turbot (Psetta Maxima Linnaeus, 1758) At Low Temperature, Ali̇ Türker Jan 2006

Effects Of Feeding Frequency On Growth, Feed Consumption, And Body Composition In Juvenile Turbot (Psetta Maxima Linnaeus, 1758) At Low Temperature, Ali̇ Türker

Turkish Journal of Veterinary & Animal Sciences

Juvenile turbot Psetta maxima (Linnaeus, 1758) (15.23 ± 2.99 g) were fed to satiation with a commercial extruded feed over a 60-day period. Feeding regimens were twice a day (TD), every other day (EOD), and 2-day intervals (TDI). Fish were kept in seawater (18 ppt) at 5-7.5 °C from January 21 to March 23, 2004. Feed conversion rate (FCR) and the protein efficiency ratios (PER) were within the ranges of 1.12-1.14 and 2.26-2.29, respectively. While the maximum relative growth rate (RGR), weight gain, and specific growth rate (SGR) were recorded in the TD group, they were lower in the EOD …


Identification And Seasonal Distribution Of Airborne Fungi In Urban Outdoor Air In An Eastern Black Sea Turkish Town, Murat Topbaş, İlknur Tosun, Gamze Çan, Neşe Kaklikkaya, Faruk Aydi̇n Jan 2006

Identification And Seasonal Distribution Of Airborne Fungi In Urban Outdoor Air In An Eastern Black Sea Turkish Town, Murat Topbaş, İlknur Tosun, Gamze Çan, Neşe Kaklikkaya, Faruk Aydi̇n

Turkish Journal of Medical Sciences

The aim of the present report was to evaluate the prevalent species of airborne fungi in the outdoor environment in the city of Trabzon, Turkey. The area is surrounded by high mountains running parallel to the Black Sea, and has a mostly rainy and temperate climate together with a most varied and widespread flora. Air samples were collected in four seasons by means of the gravitational settling method using petri dishes with SDA culture media. Those fungi colonies that formed after an incubation period of 7-10 days at 25 ºC were determined on the basis of micro and macromorphological features. …


Morbidity Pattern Among The Elderly Population In The Rural Area Of Tamil Nadu, India, Anil Jacob Purty, Joy Bazroy, Malini Kar, Kavita Vasudevan, P. Zacharia, Purushottam Panda Jan 2006

Morbidity Pattern Among The Elderly Population In The Rural Area Of Tamil Nadu, India, Anil Jacob Purty, Joy Bazroy, Malini Kar, Kavita Vasudevan, P. Zacharia, Purushottam Panda

Turkish Journal of Medical Sciences

Globally there are an estimated 605 million people aged 60 years and above. From the morbidity point of view, almost 50 per cent of the Indian elderly have chronic diseases and 5 percent suffer from immobility. A major component of the burden of illness for the elderly derives from prevalent chronic disease. Hence a study was undertaken to assess the present morbidity pattern of rural elderly persons. A community based cross-sectional study was undertaken in the rural service area of Pondicherry Institute of Medical Sciences (PIMS) between october 1, 2002 to October 31, 2003. All persons above the age of …


Exposure Of Rats To Whole Body Gamma Rays Induces Early Alterations In Biliary Secretion, Omar Mohamed Abdel-Salam, Ihsan Hadajat, Ayman Ragab Baiuomy, Siham El-Shinawy, Mahmoud S. Arbid Jan 2006

Exposure Of Rats To Whole Body Gamma Rays Induces Early Alterations In Biliary Secretion, Omar Mohamed Abdel-Salam, Ihsan Hadajat, Ayman Ragab Baiuomy, Siham El-Shinawy, Mahmoud S. Arbid

Turkish Journal of Medical Sciences

Aim: To study the effects of whole body gamma irradiation on bile flow and bile composition in rats. Methods: Three groups of male Sprague-Dawley rats were irradiated with a single 8 gray (Gy) fraction for 15-20 min and examined for bile secretion at different time intervals (18, 48, 72 h) after irradiation. For collection of biliary secretions, rats were anesthetized with intraperitoneal (i.p.) urethane (1.25 g/kg) and equipped with biliary cannulas inserted into the bile duct through the sphincter of Oddi. Bile was collected for 4 h following bile duct cannulation. Bile flow (bile-pancreatic juice) and biliary excretion of total …


Observations On Healthcare And The Cultural Perceptions Of Pain And Pain Management At Bebalem Hospital, Tchad Africa, Nealey Mccall Hearns Jan 2006

Observations On Healthcare And The Cultural Perceptions Of Pain And Pain Management At Bebalem Hospital, Tchad Africa, Nealey Mccall Hearns

Senior Honors Theses and Projects

No abstract provided.


Dentalgram - Vol. 20, No. 01, Loma Linda University School Of Dentistry Jan 2006

Dentalgram - Vol. 20, No. 01, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

  • Remembering the lives of Dr. Ronald Blank, Robert Kinzer, and Albert Burns
  • LLUSD students co-chairs national conference
  • School of Dentistry to host Investment Fair
  • Department news
  • New director of biomaterials research laboratory invites faculty to participate in research
  • James Crawford presented with Medal of Distinction by General Conference of Seventh-day Adventists
  • Banquet held for December, 2005 International Dentist Program graduates


The Speciation Of Metals In Mammals Influences Their Toxicokinetics And Toxicodynamics And Therefore Human Health Risk Assessment, Robert A. Yokel, Stephen M. Lasley, David C. Dorman Jan 2006

The Speciation Of Metals In Mammals Influences Their Toxicokinetics And Toxicodynamics And Therefore Human Health Risk Assessment, Robert A. Yokel, Stephen M. Lasley, David C. Dorman

Pharmaceutical Sciences Faculty Publications

Chemical form (i.e., species) can influence metal toxicokinetics and toxicodynamics and should be considered to improve human health risk assessment. Factors that influence metal speciation (and examples) include: (1) carrier-mediated processes for specific metal species (arsenic, chromium, lead and manganese), (2) valence state (arsenic, chromium, manganese and mercury), (3) particle size (lead and manganese), (4) the nature of metal binding ligands (aluminum, arsenic, chromium, lead, and manganese), (5) whether the metal is an organic versus inorganic species (arsenic, lead, and mercury), and (6) biotransformation of metal species (aluminum, arsenic, chromium, lead, manganese and mercury). The influence of speciation on metal …


Vignettes: Diverse Library Staff Offering Diverse Bioinformatics Services, David L. Osterbur, Kristine Alpi, Catarine Canevari, Pamela M. Corley, Medha Devare, Nicola Gaedeke, Donna K. Jacobs, Peter Kirlew, Janet A. Ohles, K.T.L. Vaughan, Lili Wang, Yongchun Wu, Renata C. Greer Jan 2006

Vignettes: Diverse Library Staff Offering Diverse Bioinformatics Services, David L. Osterbur, Kristine Alpi, Catarine Canevari, Pamela M. Corley, Medha Devare, Nicola Gaedeke, Donna K. Jacobs, Peter Kirlew, Janet A. Ohles, K.T.L. Vaughan, Lili Wang, Yongchun Wu, Renata C. Greer

Open Access Publications

No abstract provided.


Human Sensory-Evoked Responses Differ Coincident With Either "Fusion-Memory" Or "Flash-Memory", As Shown By Stimulus Repetition-Rate Effects, Don L. Jewett, Toryalai Hart, Linda J. Larson-Prior, Bill Baird, Marram Olson, Michael Trumpis, Katherine Makayed, Payam Bavafa Jan 2006

Human Sensory-Evoked Responses Differ Coincident With Either "Fusion-Memory" Or "Flash-Memory", As Shown By Stimulus Repetition-Rate Effects, Don L. Jewett, Toryalai Hart, Linda J. Larson-Prior, Bill Baird, Marram Olson, Michael Trumpis, Katherine Makayed, Payam Bavafa

Open Access Publications

No abstract provided.


Rapid Determination Of Reduced And Oxidized Glutathione Levels Using A New Thiol-Masking Reagent And The Enzymatic Recycling Method: Application To The Rat Liver And Bile Samples, Imam H. Shaik, Reza Mehvar Jan 2006

Rapid Determination Of Reduced And Oxidized Glutathione Levels Using A New Thiol-Masking Reagent And The Enzymatic Recycling Method: Application To The Rat Liver And Bile Samples, Imam H. Shaik, Reza Mehvar

Pharmacy Faculty Articles and Research

A microtiter plate assay for quantitation of reduced (GSH) and oxidized (GSSG) glutathione in the rat liver tissue and bile is described. The assay is based on the established enzymatic recycling method and a new thiol-masking reagent, 1-methyl-4-vinyl-pyridinium trifluoromethane sulfonate (M4VP). Samples were first processed by homogenization with (liver) or addition of (bile) sulfosalicylic acid. The total glutathione and GSSG were then determined before and after rapid (>= 2 min) and efficient (100%) masking of the GSH content of the samples with M4VP followed by the enzymatic recycling assay. The percentages of error and coefficient of variation of the …


Woman- Centered Post-Abortion Care In Public Hospitals In Tucuman, Argentina: Assessing Quality Of Care And Its Link To Human Rights, Rodolfo Gomez Ponce De Leon Phd, Deborah Lynn Billings Phd, Karina Barrionuevo Jan 2006

Woman- Centered Post-Abortion Care In Public Hospitals In Tucuman, Argentina: Assessing Quality Of Care And Its Link To Human Rights, Rodolfo Gomez Ponce De Leon Phd, Deborah Lynn Billings Phd, Karina Barrionuevo

Faculty Publications

Unsafe abortion is a major public health and human rights problem in
Argentina. Implementation of a woman-centered post-abortion care
(PAC) model is one strategy to improve the situation. The quality of PAC
services was measured in three public hospitals in Tucumin, a province
with high levels of poverty and maternal mortality due to unsafe abortion.
Overall, the quality of PAC services was found to be poor. Women
do not receive services in a manner that respects their human rights, in
particular their rights to health and health care, information, and to the
benefits of scientific progress. Findings from the evaluation …


Woman-Centered Post-Abortion Care In Public Hospitals In Tucumán, Argentina: Assessing Quality Of Care And Its Link To Human Rights, Rodolfo Gómez Ponce De León, Deborah Lynn Billings, Karina Barrionuevo Jan 2006

Woman-Centered Post-Abortion Care In Public Hospitals In Tucumán, Argentina: Assessing Quality Of Care And Its Link To Human Rights, Rodolfo Gómez Ponce De León, Deborah Lynn Billings, Karina Barrionuevo

Faculty Publications

Unsafe abortion is a major public health and human rights problem in Argentina. Implementation of a woman-centered post-abortion care (PAC) model is one strategy to improve the situation. The quality of PAC services was measured in three public hospitals in Tucumán, a province with high levels of poverty and maternal mortality due to unsafe abortion. Overall, the quality of PAC services was found to be poor. Women do not receive services in a manner that respects their human rights, in particular their rights to health and health care, information, and to the benefits of scientific progress. Findings from the evaluation …


Metacarpal-Phalangeal Arthroplasty: A Post-Operative Approach, Lance Norman Jan 2006

Metacarpal-Phalangeal Arthroplasty: A Post-Operative Approach, Lance Norman

Occupational Therapy Capstones

No abstract provided.


Traumatic Brain Injury (Tbi): Caregiver And Family Education Handbook, Heather Yekel, Breana Medlock Jan 2006

Traumatic Brain Injury (Tbi): Caregiver And Family Education Handbook, Heather Yekel, Breana Medlock

Occupational Therapy Capstones

Life can be very confusing for the friends, family member(s), and caretaker(s) of those individuals who are diagnosed with a Traumatic Brain Injury (TBI). The people who live with and care for the individual with a TBI want to know how they can help and what they can do to speed up the recovery. They also want to know what they can expect from their loved one, how much time the recovery will take, and what is causing the changes in their behavior?

A review of the literature was conducted and professionals, who are currently providing services to individuals diagnosed …


Nurture Your Infant And Yourself: A Breastfeeding Program, Kathryn J. Conrad Jan 2006

Nurture Your Infant And Yourself: A Breastfeeding Program, Kathryn J. Conrad

Occupational Therapy Capstones

No abstract provided.


Livin' Right! Morning, Noon, And Night: A Multi-Disciplinary Wellness Camp [For] Children With Obesity Issues, Lynne R. Bradbury Jan 2006

Livin' Right! Morning, Noon, And Night: A Multi-Disciplinary Wellness Camp [For] Children With Obesity Issues, Lynne R. Bradbury

Occupational Therapy Capstones

The prevalence of childhood obesity is rapidly increasing in the United States and the percentage of overweight or obese children in South Dakota exceeds the objective set by the U.S. Department of Health and Human Services (2000). An extensive review of literature was completed on the prevalence and characteristics of obesity in children as well as interventions such as a multi-disciplinary team approach and family involvement. A review of the use of measurement tools both for screening and outcome measures was also conducted. There are significant health and societal impacts that accompany the increasing prevalence of obesity in our communities. …


Children With Limb Deficiency: The Impacts Of Using A Prosthetic For Functional Independence, Kirsten Brandt, Michelle Grimes Jan 2006

Children With Limb Deficiency: The Impacts Of Using A Prosthetic For Functional Independence, Kirsten Brandt, Michelle Grimes

Occupational Therapy Capstones

Many emotions, questions, and concerns may arise for parents and caregivers upon learning that their child has a limb deficiency. Educational resources for parents of children with limb deficiencies may be lengthy, time consuming to find and read, and full of medical jargon. The purpose of this scholarly project was to develop an educational booklet that is concise and easy to read for parents and caregivers of children with limb deficiencies.

An extensive literature review was conducted addressing the physical and psychological impacts children with limb deficiencies experience during daily activities. Parents with children who have limb deficiencies, individuals with …


School-Based Practice: Integrating The Occupational Therapy Practice Framework, Nancy M. Daly Jan 2006

School-Based Practice: Integrating The Occupational Therapy Practice Framework, Nancy M. Daly

Occupational Therapy Capstones

Occupational therapists in school-based practice frequently experience change due to the evolution of the profession and education reform. This project examines the impact of these changes relative to the integration of client-centered and occupation-based services in contemporary educational practice. Occupational therapists have identified significant barriers that impact the efficiency and effectiveness of service delivery. This paper, through the review of current occupational therapy and special education literature, explores the integration of collaboration, client-centered occupation-based care, and service delivery. The increasing requirements for accountability and professional standards define documentation needs. Findings indicate a need for school-based occupational therapists to have processes …


Eating Disorder Programming In Four-Year College Recreation Wellness Centers, Tiffany Jean Anderson, Amanda Lynn Gulka Jan 2006

Eating Disorder Programming In Four-Year College Recreation Wellness Centers, Tiffany Jean Anderson, Amanda Lynn Gulka

Physical Therapy Scholarly Projects

Eating disorders are more prevalent in the college-age group when compared to the lifetime prevalence. Because of this increased prevalence, college recreation/wellness center staff should be aware of their clients in terms of the increased risk for eating disorders. College wellness/recreation centers, while serving the campus community, also serve the individuals within this community diagnosed with or at-risk for an eating disorder. Through survey research, we show who is employed at wellness/recreation centers, what type of training they receive regarding eating disorder, how this training is provided along with its content, and what method of public awareness on eating disorders …


Muscle Activation In Individuals Who Are Status-Post A Stroke During Over Ground, Treadmill, And Body Weight Supported Gait: A Comparative Study, Rhonda L. Breitbach, Kelly L. Malmin, Beth M. Nordmark, Jennifer A. Pederson Jan 2006

Muscle Activation In Individuals Who Are Status-Post A Stroke During Over Ground, Treadmill, And Body Weight Supported Gait: A Comparative Study, Rhonda L. Breitbach, Kelly L. Malmin, Beth M. Nordmark, Jennifer A. Pederson

Physical Therapy Scholarly Projects

Purpose: The purpose of this study was to evaluate individuals who are status post stroke during ambulation over ground, on a treadmill without support, and on a treadmill with partial body weight support (PBWS) to determine if there are any differences in muscle activation of major muscle groups in the lower extremity.

Subjects: Two subjects were recruited for this study. Subjects were included if they were over the age of 50 years, could fulfill a two-hour time commitment, and walk independently with or without the use of an assistive device. Subjects were excluded if they have had surgery or an …


An Electromyographic Study Of Upper Trapezius, Lower Trapezius, And Serratus Anterior Muscle Activity During Traditional And Modified Muscle Testing Positions, Jace Everett, Mike Fowler, Jason Haak, Robby Luck Jan 2006

An Electromyographic Study Of Upper Trapezius, Lower Trapezius, And Serratus Anterior Muscle Activity During Traditional And Modified Muscle Testing Positions, Jace Everett, Mike Fowler, Jason Haak, Robby Luck

Physical Therapy Scholarly Projects

Purpose: The purpose of this study is to assess the muscle activity of the shoulder joint force couple induced by the upper trapezius, lower trapezius, and serratus anterior to determine if they are more effectively recruited during the traditional exercise position of forward shoulder elevation in 145° of shoulder abduction versus a modified position of shoulder external rotation while in 80° of shoulder abduction and 90° of elbow flexion

Methods: Nine participants took part in this randomized study in which EMG data was collected during 4 exercise trials of 10 repetitions each on the right shoulder. EMG activity was monitored …


Balance Comparison Of Open- And Closed-Back Shoes, Tiffany Hemberger, Sara Henderson, Eric Loiland Jan 2006

Balance Comparison Of Open- And Closed-Back Shoes, Tiffany Hemberger, Sara Henderson, Eric Loiland

Physical Therapy Scholarly Projects

A growing number of healthcare professionals have been choosing to wear an open-back shoe rather than a traditional closed-back shoe in the workplace. Healthcare professionals incorporate dynamic balance and quick reactions during direct patient interaction. The purpose of the study was to determine if dynamic balance would be affected in healthcare professionals when wearing open-back shoes versus closed-back shoes.

Thirty-two healthcare professionals or students of healthcare professions (28 females and 4 males) were recruited for this study. Subjects ranged in age from 20 to 62 years (mean age 28.2 years), with the majority being physical therapists or physical therapy students. …


Role Of Z-Coilª Shoes On Plantar Pressure Forces During Short Distance Walking, Tyler Volle, Michael Rider, Brett Jenks, Benjamin Deubner Jan 2006

Role Of Z-Coilª Shoes On Plantar Pressure Forces During Short Distance Walking, Tyler Volle, Michael Rider, Brett Jenks, Benjamin Deubner

Physical Therapy Scholarly Projects

Purpose: The Z-CoiL ® company has marketed a shoe that is advertised to decrease pressure and attenuation of forces on the foot, ankle, and other lower extremity joints. Evidence based studies, however, are lacking in support of this claim. The purpose of this study was to compare the peak pressure distributed onto the bottom of the foot from heel strike to midstance when walking bare foot, using a personal athletic shoe, and using a Z-CoiL ® shoe.

Subjects: Thirty subjects without any current history of orthopedic pathologies were examined in this study. Fourteen subjects were excluded from final data analysis, …


Review Of Quick Reference Dictionary For Massage Therapy And Bodywork, John Stephen Brantley Jan 2006

Review Of Quick Reference Dictionary For Massage Therapy And Bodywork, John Stephen Brantley

Faculty & Staff Research & Creative Activity

No abstract provided.


Local Flexibility In Molecular Function Paradigm, Jag Bhalla, Geoffrey B. Storchan, Caitlin M. Maccarthy, Vladimir N. Uversky, Olga Tcherkasskaya Jan 2006

Local Flexibility In Molecular Function Paradigm, Jag Bhalla, Geoffrey B. Storchan, Caitlin M. Maccarthy, Vladimir N. Uversky, Olga Tcherkasskaya

Molecular Medicine Faculty Publications

It is generally accepted that the functional activity of biological macromolecules requires tightly packed three-dimensional structures. Recent theoretical and experimental evidence indicates, however, the importance of molecular flexibility for the proper functioning of some proteins. We examined high resolution structures of proteins in various functional categories with respect to the secondary structure assessment. The latter was considered as a characteristic of the inherent flexibility of a polypeptide chain. We found that the proteins in functionally competent conformational states might be comprised of 20–70% flexible residues. For instance, proteins involved in gene regulation, e.g. transcription factors, are on average largely disordered …


Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva Jan 2006

Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva

Molecular Medicine Faculty Publications

Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and the amount of predicted structural disorder, the disorder propensities of proteins with various numbers of interacting partners from four eukaryotic organisms (Caenorhabditis elegans, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens) were investigated. The results of PONDR VL-XT disorder analysis show that for all four studied organisms, hub proteins, defined here as those that interact with ≥10 partners, are significantly more disordered than end proteins, defined here as those that interact with just one partner. …