Medicine and Health Sciences Commons^™

Isoprenoid Analogs As Chemical Genetic Tools To Provide Insights Into Farnesyl Transferase Target Selection And Cellular Activity, Jerry Troutman

University of Kentucky Doctoral Dissertations

Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP), the farnesyl group donor for the reaction, forms a significant portion of a target protein binding site. The major goal of this research was to exploit this unique property of the FTase reaction and determine if changing the structure of the farnesyl donor group would affect FTase protein targeting. A small library of structural analogues of FPP was synthesized. Michelis-Menten steady-state kinetic analyses and competition reactions were used to …

The Present State Of Nfp Science, The Challenges We Face, Richard J. Fehring

College of Nursing Faculty Research and Publications

No abstract provided.

Woman-Centered Post-Abortion Care In Public Hospitals In Tucumán, Argentina: Assessing Quality Of Care And Its Link To Human Rights, Rodolfo Gómez Ponce De León, Deborah Lynn Billings, Karina Barrionuevo

Faculty Publications

Unsafe abortion is a major public health and human rights problem in Argentina. Implementation of a woman-centered post-abortion care (PAC) model is one strategy to improve the situation. The quality of PAC services was measured in three public hospitals in Tucumán, a province with high levels of poverty and maternal mortality due to unsafe abortion. Overall, the quality of PAC services was found to be poor. Women do not receive services in a manner that respects their human rights, in particular their rights to health and health care, information, and to the benefits of scientific progress. Findings from the evaluation …

Effect Of Keyswitch Design Of Desktop And Notebook Keyboards Related To Key Stiffness And Typing Force, Marcia J. Bufton, Richard W. Marklin, Mark L. Nagurka, Guy G. Simoneau

Mechanical Engineering Faculty Research and Publications

This study aimed to compare and analyse rubber-dome desktop, spring column desktop and notebook keyboards in terms of key stiffness and fingertip typing force. The spring-column keyboard resulted in the highest mean peak contact force (0.86N), followed by the rubber dome desktop (0.68N) and the notebook (0.59N). All these differences were statistically significant. Likewise, the spring-column keyboard registered the highest fingertip typing force and the notebook keyboard the lowest. A comparison of forces showed the notebook (rubber dome) keyboard had the highest fingertip-to-peak contact force ratio (overstrike force), and the spring-column generated the least excess force (as a ratio of …

Combining Linear Regression With Reconstructability Analysis: A Study Of Differences In Health Status, Renato Carletti, Martin Zwick

Complex Systems Faculty Publications and Presentations

A linear regression model was used to predict variations in health status with the hypothesis that literacy level as a proximal measure for educational attainment would show a strong correlation with health status. Groups of other independent variables have also been introduced in the model to test whether the effect of literacy on health would have been mediated by other factors, or increased by them. The linear regression model did not show any strong relation between literacy and health, but pointed to other factors as predictors of health status.

Methods of data mining have been used for exploring throughout all …