Medicine and Health Sciences Commons^™

Wildlife-Cattle Interactions In Northern Michigan: Implications For The Transmission Of Bovine Tuberculosis, Jerry Alan Hill

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis (Mycobacterium bovis) was discovered in northern Michigan white-tailed deer (Odocoileus virginianus) in 1994, and has been known to exist in Michigan cattle herds since 1998. Despite efforts to eradicate the disease in cattle, infection and re-infection of farms continues to occur, suggesting transmission among cattle, deer, or other wildlife reservoirs. The goals of this study were to document wildlife activity on farms and evaluate the possible role wildlife play in the ecology of bovine tuberculosis (TB) in Michigan. Visual observations were conducted on farms in a 5-county area of northern Michigan to document direct …

Mycobacterium Avium Subsp. Paratuberculosis From Free-Ranging Deer And Rabbits Surrounding Minnesota Dairy Herds, Eran A. Raizman, Scott J. Wells, Peter A. Jordan, Glenn D. Delgiudice, Russell R. Bey

Michigan Bovine Tuberculosis Bibliography and Database

The objectives of this study were to estimate the prevalence of Mycobacterium avium subsp. paratuberculosis (MAP) among deer and rabbits surrounding infected and noninfected Minnesota dairy farms using fecal culture, and to describe the frequency that farm management practices were used that could potentially lead to transmission of infection between these species. Fecal samples from cows and the cow environment were collected from 108 Minnesota dairy herds, and fecal pellets from free-ranging white-tailed deer and eastern cottontail rabbits were collected from locations surrounding 114 farms; all samples were tested using bacterial culture. In addition, a questionnaire was administered to 114 …

Yellow Fever Vaccine: An Updated Assessment Of Advanced Age As A Risk Factor For Serious Adverse Events, Alena Y. Khromava, Rachel Barwick Eidex, Leisa H. Weld, Katrin S. Kohl, Robert D. Bradshaw, Robert T. Chen, Martin S. Cetron

Uniformed Services University of the Health Sciences

Since 1996, the scientific community has become aware of 14 reports of yellow fever vaccine (YEL)-associated viscerotropic disease (YEL-AVD) cases and four reports of YEL-associated neurotropic disease (YEL-AND) worldwide, changing our understanding of the risks of the vaccine. Based on 722 adverse event reports after YEL submitted to the U.S. Vaccine Adverse Event Reporting System in 1990–2002, we updated the estimates of the age-adjusted reporting rates of serious adverse events, YEL-AVD and YEL-AND.We found that the reporting rates of serious adverse events were significantly higher among vaccinees aged ≥60 years than among those 19–29 years of age (reporting rate ratio …

Factor Structure And Construct Validity Of The Anxiety Sensitivity Index Among Island Puerto Ricans, Jennifer A. Cintrón, Michele M. Carter, Sonia Suchday, Tracy Sbrocco, James Gray

Uniformed Services University of the Health Sciences

The factor structure and convergent and discriminant validity of the Anxiety Sensitivity Index (ASI) were examined among a sample of 275 island Puerto Ricans. Results from a confirmatory factor analysis (CFA) comparing our data to factor solutions commonly reported as representative of European American and Spanish populations indicated a poor fit. A subsequent exploratory factor analysis (EFA) indicated that a two-factor solution (Factor 1, Anxiety Sensitivity; Factor 2, Emotional Concerns) provided the best fit. Correlations between the ASI and anxiety measures were moderately high providing evidence of convergent validity, while correlations between the ASI and BDI were significantly lower providing …

Targeting Of Tsc13p To Nucleus–Vacuole Junctions: A Role For Very-Long-Chain Fatty Acids In The Biogenesis Of Microautophagic Vesicles, Erik Kvam, Kenneth Gable, Teresa M. Dunn, David S. Goldfarb

Uniformed Services University of the Health Sciences

TSC13 is required for the biosynthesis of very-long-chain fatty acids (VLCFAs) in yeast. Tsc13p is a polytopic endoplasmic reticulum (ER) membrane protein that accumulates at nucleus–vacuole (NV) junctions, which are formed through Velcro-like interactions between Nvj1p in the perinuclear ER and Vac8p on the vacuole membrane. NV junctions mediate piecemeal microautophagy of the nucleus (PMN), during which bleb-like portions of the nucleus are extruded into invaginations of the vacuole membrane and degraded in the vacuole lumen. We report that Tsc13p is sequestered into NV junctions from the peripheral ER through Vac8p-independent interactions with Nvj1p. During nutrient limitation, Tsc13p is incorporated …

As Two Become One : The Lived Experience Of A Twinless Twin, Jody Ness

Electronic Theses and Dissertations

Twins enter life as a pair and are often viewed so in later life. After the death of a co-twin, twins feel like they have lost part of themselves, leaving them alone, often without professional help. No nursing research has provided insight into the experience of a twin who has lost their co-twin. The purpose of this research was to explore and describe the lived experience of a twin who has lost their co-twin. The aim was to generate an understanding of the unique bond and sense of loss experienced by twinless twins. Phenomenology and Attachment Theory were utilized to …

Heart Rate Variability In Non-Apneic Snorers And Controls Before And After Continuous Positive Airway Pressure, Gregory J. Gates, Susan E. Mateika, Jason H. Mateika

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

We hypothesized that sympathetic nervous system activity (SNSA) is increased and parasympathetic nervous system activity (PNSA) is decreased during non-rapid eye movement (NREM) sleep in non-apneic, otherwise healthy, snoring individuals compared to control. Moreover, we hypothesized that these alterations in snoring individuals would be more evident during non-snoring than snoring when compared to control.

Methods

To test these hypotheses, heart rate variability was used to measure PNSA and SNSA in 11 normotensive non-apneic snorers and 12 control subjects before and 7-days after adapting to nasal continuous positive airway pressure (nCPAP).

Results

Our results showed that SNSA was increased …

The Role Of Aromatase Inhibitors In Ameliorating Deleterious Effects Of Ovarian Stimulation On Outcome Of Infertility Treatment, Mohamed Fm Mitwally, Robert F. Casper, Michael P. Diamond

Wayne State University Associated BioMed Central Scholarship

Abstract

Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum …

Gene Expression Profiling Revealed Novel Mechanism Of Action Of Taxotere And Furtulon In Prostate Cancer Cells, Yiwei Li, Maha Hussain, Sarah H. Sarkar, James Eliason, Ran Li, Fazlul H. Sarkar

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Both Taxotere and Capecitabine have shown anti-cancer activity against various cancers including prostate cancer. In combination, Taxotere plus Capecitabine has demonstrated higher anti-cancer activity in advanced breast cancers. However, the molecular mechanisms of action of Taxotere and Capecitabine have not been fully elucidated in prostate cancer.

Methods

The total RNA from PC3 and LNCaP prostate cells untreated and treated with 2 nM Taxotere, 110 μM Furtulon (active metabolite of Capecitabine), or 1 nM Taxotere plus 50 μM Furtulon for 6, 36, and 72 hours, was subjected to Affymetrix Human Genome U133A Array analysis. Real-time PCR and Western Blot …

Expression Pattern And Regulation Of Genes Differ Between Fibroblasts Of Adhesion And Normal Human Peritoneum, Ujjwal K. Rout, Ghassan M. Saed, Michael P. Diamond

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Injury to the peritoneum during surgery is followed by a healing process that frequently results in the attachment of adjacent organs by a fibrous mass, referred commonly as adhesions. Because injuries to the peritoneum during surgery are inevitable, it is imperative that we understand the mechanisms of adhesion formation to prevent its occurrence. This requires thorough understanding of the molecular sequence that results in the attachment of injured peritoneum and the development of fibrous tissue. Recent data show that fibroblasts from the injured peritoneum may play a critical role in the formation of adhesion tissues. Therefore, identifying changes …

The Relationships Between Depression And Other Outcomes Of Chronic Illness Caregiving, Pao-Feng Tsai, Mary M. Jirovec

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Many caregivers with chronically ill relatives suffer from depression. However, the relationship of depression to other outcomes of chronic caregiving remains unclear. This study tested a hypothesized model which proposed that hours of care, stressful life events, social support, age and gender would predict caregivers' outcomes through perceived caregiver stress. Depression was expected to mediate the relationship between perceived stress and outcomes of chronic caregiving (physical function, self-esteem, and marital satisfaction).

Methods

The sample for this secondary data analysis consisted of 236 and 271 subjects from the Americans' Changing Lives, Wave 1, 1986, and Wave 2, 1989, data …

Sequential Super-Stereotypy Of An Instinctive Fixed Action Pattern In Hyper-Dopaminergic Mutant Mice: A Model Of Obsessive Compulsive Disorder And Tourette's, Kent C. Berridge, J Wayne Aldridge, Kimberly R. Houchard, Xiaoxi Zhuang

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Excessive sequential stereotypy of behavioral patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential patterns of action, language, or thought. Some instinctive behavioral patterns of animals, such as the syntactic grooming chain pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential patterns. A syntactic grooming chain is a fixed action pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New …

Childhood Cancer Among Arab Americans In Southeast Michigan, Hadi Sawaf, Adonis Lorenzana, George Dombi, Merlin Hamre, Kendra Schwartz

FMPHS Faculty Publications

Cancer is relatively rare among children, yet it remains an important public concern. Childhood cancer ranks second as a cause of death after accidents. Population-based data such as Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute create an opportunity to study the effect of ethnic background on the incidence and mortality of cancer. Studies on migrants have been widely used to infer the relative importance of environmental factors versus inherited factors and have proved valuable in developing population-specific interventions. Unfortunately, information on cancer occurrence among Arab Americans is lacking because of incomplete reporting of nationality and …

A Randomized, Controlled Trial Of In-Home Drinking Water Intervention To Reduce Gastrointestinal Illness, John M. Colford, Timothy J. Wade, Sukhminder K. Sandhu, Catherine C. Wright, Sherline Lee, Susan Shaw, Kim Fox, Susan Burns, Anne Benker, M. Alan Brookhart, Mark Van Der Laan, Deborah A. Levy

Journal Articles: Epidemiology

Trials have provided conflicting estimates of the risk of gastrointestinal illness attributable to tap water. To estimate this risk in an Iowa community with a well-run water utility with microbiologically challenged source water, the authors of this 2000-2002 study randomly assigned blinded volunteers to use externally identical devices (active device: 227 households with 646 persons; sham device: 229 households with 650 persons) for 6 months (cycle A). Each group then switched to the opposite device for 6 months (cycle B). The active device contained a 1-microm absolute ceramic filter and used ultraviolet light. Episodes of "highly credible gastrointestinal illness," a …

Effect Of Genetic Variation On The Formation Of Hepatocarcinogenic Metabolites Of Trichloroethylene Using Chloral Hydrate Studies (An Interdisciplinary Approach), Apryl Bronley-Delancey

MUSC Theses and Dissertations

Trichloroethylene (TCE) is listed with the EPA as a suspected human carcinogen and is ubiquitous in the environment (US EPA 1992). Chloral hydrate (CH) is a sedative drug and a cytochrome P450 (CYP 450)-derived metabolite of TCE (Klaassen 2001). Chloral hydrate is metabolized in the liver to the rodent hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase (ALDH), and to the non-carcinogenic metabolite trichloroethanol (TCEOH) by alcohol dehydrogenase (ADH) (Klaassen 2001). Both ALDH and ADH are polymorphic in humans which can presumably predict the disposition of chloral hydrate into the carcinogenic vs. non-carcinogenic pathways. The likelihood is then raised that subpopulations of …

Prenatal Care Utilization As A Predictor Of Failure To Thrive, Cynthia L. Allen

MUSC Theses and Dissertations

This case-control study used an academic health sciences center sample to examine differences in prenatal care utilization (defined by the number of prenatal care visits and gestational age at entry into prenatal care) between failure to thrive infants and healthy infants; and test prenatal care utilization as a predictor of failure to thrive. This study described maternal bonding characteristics (prenatal care utilization, infant length of hospital stay, feeding method, frequency of all/visits, and discharge teaching) of hospitalized failure to thrive infants. Using the Medical University of South Carolina Perinatal Information System, Keane System, and Practice Partner databases, a study sample …

What Is The Safety And Efficacy Of Biobrane Versus Silver Sulfadiazine In The Treatment Of Low Body Surface Area Partial-Thickness Burns?, Gregory Wanner

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine how the synthetic skin substitute Biobrane compares to silver sulfadiazine (SSD, silvadine) in the treatment of patients with low body surface area partial thickness burns.

Ada Code Of Ethics (January 2005), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

2005 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

2005 Supplement Vol. 1, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

2005 Supplement Vol. 2, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

Synapsis: Philadelphia Campus (2005), Philadelphia College Of Osteopathic Medicine

All Yearbooks

The 2005 Synapsis includesTrips, Parties, Formal, Prom, Dinner, White Coat Ceremony, Football, Soccer, Golf, Basketball, Frisbee, Men's Rugby, Women's Rugby, Halloween, DO Day on the Hill, Military, Clinics, Picnic, Physician Assistant Program, PA Student Olympics, American Academy of Physician Assistants, AAPA, AAPA Conference, Biomedical Sciences Program, Psychology Program, Forensic Medicine Program, Clubs, A Capella, American College Of Osteopathic Family Practitioners, ACOFP, American Holistic Medical Association, AHMA, Asian Pacific American Medical Student Association, American Medical Student Association, AMSA, American Medical Women's Association, AMWA, American Medical Association, AMA, Biomedical Sciences, Business in Medicine, Christian Medical Association, Cycling, Emergency Medicine, Internal Medicine, Association …

Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens

Biological Sciences Faculty Publications

Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we focus on vertebrate poly(A) polymerases that are members of the recently described GLD2 family. We identify and characterize two closely related GLD2 proteins in Xenopus oocytes, and show that they possess PAP activity in vivo and in vitro and that they bind known polyadenylation factors and mRNAs known to receive poly(A) during development. We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio. GLD2 protein …

Towards Wide-Field Display Of The Gripen Hud Interface To Combat Spatial Disorientation, Lars Eriksson, Katarina Undén, Claes Von Hofsten

International Symposium on Aviation Psychology - 2005

The head-up display (HUD) interface of the Gripen fighter aircraft utilizes a sphere concept for supporting attitude awareness or spatial orientation (SO). With the sphere interface fixed to the gravitational vertical and the attitude variant aircraft positioned in the center of the sphere, the HUD field-of-regard scans parts of the sphere inside. The HUD interface depicts segments of latitude circles with meridian markings that convey integrated information of pitch, roll, and yaw. To enhance pilot-in-the-loop maneuvering and SO we suggest a wide field-of-view interface design of the Gripen concept, emphasizing the inclusion of peripheral vision. The suggested interface is subsequently …

A Conceptual Framework For Studying Safety Climate And Culture Of Commercial Airlines, Dr. Sharon Glazer, Amber R. Laurel, Rangapriya Kanan Narasimhan

International Symposium on Aviation Psychology - 2005

A comprehensive safety climate and safety culture framework, which can be utilized to assess various predictors and consequences of safety climate and to assess airline’s safety culture in relation to one another, is presented. The framework depicts a process whereby individual, group, and organizational predictor variables, through perceived safety climate, affect first level outcomes. First level outcomes can lead to direct costs for the organization, as well as lowered productivity. In the framework, individual and environment variables are purported to moderate the relationship between work-related events and safety climate. Motivation is also expected to mediate the relationships between predictors and …

Distributed Air / Ground Traffic Management En Route Free Maneuvering Rules Of The Road: Requirements And Implementation For A Simulation Of En-Route Self-Separation, Nancy H. Johnson, Riva Canton, Vernol Battiste, Walter Johnson

International Symposium on Aviation Psychology - 2005

National Aeronautics and Space Administration’s (NASA) Distributed Air Ground Traffic Management (DAG-TM) program has recently investigated a concept called “En-route Free Maneuvering” as a proposed solution for expanding airspace capacity limits. A critical element for this concept is conflict detection and resolution (CD&R) using the 3D cockpit situation display (CSD). The only fielded system performing some of this function is the Traffic Alert & Collision Avoidance System (TCAS), a radar-based alerting system used by most commercial aircraft for collision detection and avoidance. TCAS is inappropriate for an en-route self-separation application due to its reactive nature, and inherent lack of flexibility. …

Redefining Crm, J. Norman Komich

International Symposium on Aviation Psychology - 2005

The recent revision (120-51E, dated 1/22/04) to the Crew Resource Management Training Advisory Circular failed to provide a specific definition of CRM. This void is an issue with those who agree with Montaigne when he observed “No wind favors the sailing ship without a destined port.” Since its inception over twenty five years ago, CRM has undergone considerable evolution and the industry now finds itself in the seventh or eighth “Generation” of CRM training. Interestingly, in the very first Advisory Circular (120-51A) the following statement was made: “The essence of CRM training is to reduce error in the cockpit.” In …

Maintaining Aircraft Orientation Awareness With Audio Displays, Kristen K. Liggett Ph.D., Peter Venero, Martin N. Anesgart Ph.D.

International Symposium on Aviation Psychology - 2005

This study was conducted to determine an appropriate task with which to test alternative orientation display formats, and to test a preliminary set of audio orientation symbology sets. Participants were required to perform three tasks simultaneously. The first task was a visual search (target designation) task. The second task was a radar monitoring task. Both of these tasks were performed on a head-down display. The third task consisted of monitoring aircraft orientation on a head-up display. The third task employed the study’s one independent variable – orientation symbology sets. When performing the aircraft orientation task, orientation was displayed in three …

A Systematic Approach To Addressing Human Factors Considerations In The Design Of Flight Deck Components, Beth Lyall Ph.D., Greg Harron M.S.

International Symposium on Aviation Psychology - 2005

The FAA Aircraft Certification Job Aid for Flight Deck Human Factors is a decision-support tool for addressing human factors considerations during the flight deck design portion of the aircraft certification process. The current version presents decision-support information related to the review of flight deck displays, controls, and systems. This tool provides a systematic approach for assessing human factors considerations related to the design of flight deck components.

The Relationship Between Controller Opinions And Use Of An Atc Decision Support Tool, Carol A. Manning, Melanie Dennis

International Symposium on Aviation Psychology - 2005

The purpose of this study was to assess the relationship between controllers’ opinions about the User Request Evaluation Tool (URET), an air traffic control decision support tool, and their use of various URET functions, including its flight data management capabilities, conflict prediction information, and problem-solving tools (e.g., trial planning). We expected that, compared with those who were less positive about URET, controllers who rated the tool more positively would use it more often in performing sector team duties. In 2002, formal observations were made of 181 en route controllers using URET at six facilities. URET display settings, usage, and use …