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Articles 1 - 30 of 97
Full-Text Articles in Medicine and Health Sciences
Characterization Of Berberine On Human Cancer Cells In Culture, Savio Szeto, Christine Miu Ngan Yow, Ka Wah Fung
Characterization Of Berberine On Human Cancer Cells In Culture, Savio Szeto, Christine Miu Ngan Yow, Ka Wah Fung
Turkish Journal of Medical Sciences
Berberine originates from a Chinese herbal medicine and possesses a wide variety of anti-cancer activities. In this study, the killing effect of berberine on nasopharyngeal carcinoma cells (NPC/HK1) was investigated. The trypan blue exclusion assay was used to assess the cytotoxic effect of berberine in this cell line. Berberine, at 5-200 µM, induced cell death in a dose-dependent manner. Treatment of cells with 200 µM berberine for 5 h yielded a lethal dose of 50% (LD50). The Comet Assay was employed to evaluate the extent of DNA damage and repair after berberine treatment (0 -100 µM). DNA damage was evident …
Accidental Displacement Of Impacted Third Molar Into Lateral Pharyngeal Space, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hakan Alpay Karasu, Yilmaz Günaydin
Accidental Displacement Of Impacted Third Molar Into Lateral Pharyngeal Space, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hakan Alpay Karasu, Yilmaz Günaydin
Turkish Journal of Medical Sciences
TAKOĞLU^1 Kemal Murat OKÇU1 Hakan Alpay KARASU^2 Yılmaz GÜNAYDIN^1 ^1Department of Oral and Maxillofacial Surgery, Dental Sciences Center, Gülhane Military Medical Academy, Etlik, Ankara, ^2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Beşevler, Ankara - Turkey
Oxidative Stress In Mothers And Their Newborns In Different Types Of Labour, İdri̇s Mehmetoğlu Akkuş, Ali̇ Kart, Osman Çağlayan, Meti̇n Çapar, Recep Gökçe
Oxidative Stress In Mothers And Their Newborns In Different Types Of Labour, İdri̇s Mehmetoğlu Akkuş, Ali̇ Kart, Osman Çağlayan, Meti̇n Çapar, Recep Gökçe
Turkish Journal of Medical Sciences
HMETOĞLU (AKKUŞ)^1 Ali KART^1 Osman ÇAĞLAYAN^1 Metin ÇAPAR^2 Recep GÖKÇE^1 Departments of 1Biochemistry, 2Obstetrics and Gynaecology, Faculty of Medicine, Selçuk University. Konya - Turkey
A Simple Comparison Between Simultaneous Kidney-Pancreas (Skptx) And Kidney-Alone (Ktx) Transplants In Type I Diabetic Nephropaty, Tanju Acar, Arshad Mahmood
A Simple Comparison Between Simultaneous Kidney-Pancreas (Skptx) And Kidney-Alone (Ktx) Transplants In Type I Diabetic Nephropaty, Tanju Acar, Arshad Mahmood
Turkish Journal of Medical Sciences
Simultaneous kidney-pancreas transplantation (SKPtx) is an established procedure at many transplant centres for the treatment of end-stage renal disease from type I diabetes mellitus. A successful transplant normalises glucose metabolism and may prevent or reverse some of the complications of diabetes. Concerning graft survival and morbidity rates, the usefulness of this procedure is still questioned by some authors (1,2). We undertook a retrospective study to investigate the differences between survival rates of SKPtx and kidney alone transplant (Ktx) recipients.We also evaluated morbidity rates and complications in both groups. There were no significant differences in 12 and 36 month survival rates. …
Papillary Adenocarcinoma Of The Epiglottis, Sema Hücümenoğlu, Nur Çeli̇k, Gülben Erdem, Si̇nan Kocatürk
Papillary Adenocarcinoma Of The Epiglottis, Sema Hücümenoğlu, Nur Çeli̇k, Gülben Erdem, Si̇nan Kocatürk
Turkish Journal of Medical Sciences
ÜMENOĞLU^1 Nur ÇELİK^1 Gülben ERDEM^1 Sinan KOCATÜRK^2 Departments of ^1Pathology, ^2Otorhinolaryngology, SSK Training and Research Hospital, Ankara, Turkey
The Effects Of Three Neurosurgical Anaesthetic Methods On Hla-Dr Expression, Nusa Tuna, Meti̇n Tuna, Demet Koca, Şebnem Atici, Aniş Ariboğan
The Effects Of Three Neurosurgical Anaesthetic Methods On Hla-Dr Expression, Nusa Tuna, Meti̇n Tuna, Demet Koca, Şebnem Atici, Aniş Ariboğan
Turkish Journal of Medical Sciences
Expression of human leukocyte antigen-DR (HLA-DR) is considered a meaningful indicator of immune response because of the important role that HLA-DR plays in presenting antigen to T-lymphocytes. The aim of this study was to evaluate the effects of three anaesthetic methods (intravenous anaesthesia with propofol-fentanyl and balanced anaesthesia with isoflurane-fentanyl or sevoflurane-fentanyl) on monocytic HLA-DR expression in neurosurgical patients who underwent craniotomy. Thirty patients were divided into 3 groups of 10, and each group was the subject of one of the anaesthetic regimes noted above during craniotomy procedures. Blood samples were collected and HLA-DR expression was measured by flow cytometry …
Arsenic Trioxide Has Additive Cytotoxic Effects On Mcf-7 Breast Cancer Cell Line With Taxanes, Canfeza Sezgi̇n, Ulus Ali̇ Şanli, Rüçhan Uslu, Erdem Göker
Arsenic Trioxide Has Additive Cytotoxic Effects On Mcf-7 Breast Cancer Cell Line With Taxanes, Canfeza Sezgi̇n, Ulus Ali̇ Şanli, Rüçhan Uslu, Erdem Göker
Turkish Journal of Medical Sciences
Breast cancer is the most prevalent cancer in women and an important cause of both morbidity and mortality. Although long-term disease-free survival is offered to women with early stage disease by current treatment modality, some, 30-40% of patients will have metastatic disease. Treatment of patients with metastatic disease is a great challenge for oncologists. Therefore, new drugs and therapeutic options for women with metastatic breast cancer are urgently required. Arsenical compounds have cytotoxic effects on several cancer cell lines including promyelocytic leukemia, esophageal carcinoma, megakaryocytic leukemia, and malignant lymphocytic cell lines. In addition, recent studies showed that arsenic trioxide (As_2O_3) …
Analyses Of Surface Dose From High Energy Photon Beams For Different Clinical Setup Parameters, Nadi̇r Küçük, Ayhan Kiliç, Gönül Kemi̇kler, Lütfi̇ Özkan, Kayihan Engi̇n
Analyses Of Surface Dose From High Energy Photon Beams For Different Clinical Setup Parameters, Nadi̇r Küçük, Ayhan Kiliç, Gönül Kemi̇kler, Lütfi̇ Özkan, Kayihan Engi̇n
Turkish Journal of Medical Sciences
Surface and build-up region doses of 6, 15 and 25 MV photon beams were investigated for several clinical setup parameters. Evaluated setups included open fields, physical wedge (PW) fields, virtual wedge (VW) fields and blocked fields. The effects of field size, acrylic block tray, source-to-surface distance (SSD) and off-axis distance on surface dose were determined for each of these setups. Siemens Mevatron MD2 (6-15 MV) and Mevatron-KD2 (6-25 MV) linear accelerators were used to measure both the surface and build-up region doses. The surface dose increased as field size increased in open fields. There was no significant difference between 6 …
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Turkish Journal of Medical Sciences
Epidemiologic studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. The evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved in hormone metabolism may be a cost effective manner in which to determine individual breast cancer susceptibility. A number of molecular epidemiologic studies have been conducted to evaluate associations between polymorphic genes involved in steroid hormone metabolism (i.e., CYP17, CYP19, CYP1A1, CYP1B1, MnSOD, COMT, and GST) that may account for a proportion of enzymatic variability. An evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved …
Detection Of Human Papillomavirus Infection In Esophageal Carcinomas By The Histopathological Method And Polymerase Chain Reaction Technique, İlhami̇ Ki̇ki̇, Mehmet Gündoğdu, Muhammet Fevzi̇ Polat, Cemal Gündoğdu
Detection Of Human Papillomavirus Infection In Esophageal Carcinomas By The Histopathological Method And Polymerase Chain Reaction Technique, İlhami̇ Ki̇ki̇, Mehmet Gündoğdu, Muhammet Fevzi̇ Polat, Cemal Gündoğdu
Turkish Journal of Medical Sciences
A series of 30 surgical resection materials of patients with squamous cell carcinoma (SCC) and 10 with adenocarcinoma (AC) were analyzed histologically and by polymerase chain reaction (PCR) to demonstrate whether human papillomavirus (HPV) has a role in the etiology of esophageal cancers. Epithelial changes suggesting HPV infection were histopathologically detected in 19 of 30 (63.3%) SCC and in 4 of 10 (40%) AC cases. By PCR, HPV type 16 and/or type 18 DNA were detected in 10 of 30 (33.3%) SCC and HPV type 18 DNA alone was detected in 1 of 10 (10%) AC cases. Histopathologic findings related …
Intraarticular Cyst Of The Knee, Gülay Yeği̇noğlu, Osman Aynaci, Ahmet Uğur Turhan
Intraarticular Cyst Of The Knee, Gülay Yeği̇noğlu, Osman Aynaci, Ahmet Uğur Turhan
Turkish Journal of Medical Sciences
GİNOĞLU^1 Osman AYNACI^2 Ahmet Uğur TURHAN^2 Department of ^1Anatomy, ^2Orthopedic Surgery, School of Medicine, Karadeniz Technical University, 61080 Trabzon - Turkey
Clinical Evaluation Of The Fastplaquetb For The Rapid Diagnosis Of Pulmonary Tuberculosis, Cengi̇z Çavuşoğlu, Sevi̇nç Güneri̇, Mutay Suntur, Altinay Bi̇lgi̇ç
Clinical Evaluation Of The Fastplaquetb For The Rapid Diagnosis Of Pulmonary Tuberculosis, Cengi̇z Çavuşoğlu, Sevi̇nç Güneri̇, Mutay Suntur, Altinay Bi̇lgi̇ç
Turkish Journal of Medical Sciences
The reliability of the FASTPlaqueTB (FPTB) test (Biotec Ltd.) for the rapid diagnosis of pulmonary tuberculosis was evaluated and its diagnostic performance was compared with the Amplified Mycobacterium Tuberculosis Direct (MTD) test (Gen-Probe) by testing 80 sputum samples obtained from 77 patients. The results were compared to those of mycobacterial culture, smear and clinical course. After a chart review 14 culture-negative patients who had been on antituberculosis therapy before the study began were excluded from the final analysis. Of the remaining 63 patients, 33 were considered to have tuberculosis; 29 of them were both smear and culture positive, for whom …
Penetrating Cardiac Injuries, Ahmet Özyazicioğlu, Azman Ateş, Münacetti̇n Cevi̇z, Sami̇ Karapolat, Engi̇n Bozkurt, Hi̇kmet Koçak
Penetrating Cardiac Injuries, Ahmet Özyazicioğlu, Azman Ateş, Münacetti̇n Cevi̇z, Sami̇ Karapolat, Engi̇n Bozkurt, Hi̇kmet Koçak
Turkish Journal of Medical Sciences
Objectives: To present our experience of penetrating cardiac injuries treated at Atatürk University hospital; in 17 years 38 patients were analyzed. Methods: Patients were classified into three groups: group A (stable), 12; group B (shock), 21; and group C (agonal), five. Five patients were treated by pericardial window and three by pericardiocentesis. Two patients in group C, 19 patients in group B and five patients in group A underwent median sternotomy or thoracotomy in the operating room. Emergency room thoracotomies were performed in four patients. Results: There were 12 patients in group A, of which 11 survived (92 %). Of …
An Alternative Method To The Volume Estimation Of Cavities With Irregular Surface In The Cadaver: Measuring Right Cardiac Ventricle Of The Fetus By Using Mercury, Zeli̇ha Kurtoğlu, M. Haluk Uluutku
An Alternative Method To The Volume Estimation Of Cavities With Irregular Surface In The Cadaver: Measuring Right Cardiac Ventricle Of The Fetus By Using Mercury, Zeli̇ha Kurtoğlu, M. Haluk Uluutku
Turkish Journal of Medical Sciences
To find the volume of irregular cavities in cadavers, many researchers have used different methods including filling with any fluid and calculating the volume by usingcomplex geometrical formulas. All of these have some difficulties and disadvantages. In this paper, filling cavities with mercury is presented as an alternative method for volume estimation of the cavities. The volumes of 22 right cardiac ventricles were found by using mercury in 27-34 week-old fetuses. The method was proposed as an easy and sensitive method for volume estimation and comparison of the cavities in the cadaver.
Invasive Pulmonary Aspergillosis In Solid-Organ Transplant Recipients: Postmortem Histopathologic Findings, Banu Bi̇lezi̇kçi̇, Beyhan Demi̇rhan, Asuman Ni̇han Haberal, Ünser Arikan
Invasive Pulmonary Aspergillosis In Solid-Organ Transplant Recipients: Postmortem Histopathologic Findings, Banu Bi̇lezi̇kçi̇, Beyhan Demi̇rhan, Asuman Ni̇han Haberal, Ünser Arikan
Turkish Journal of Medical Sciences
Invasive aspergillosis is often lethal in transplant recipients. The mortality associated with this disease after organ transplantation approaches 100%, partly because it is difficult to recognize and diagnose early on. The clinical course and histological findings in invasive pulmonary aspergillosis in immunocompromised hosts differ from those seen in patients who develop classic aspergillomas. In immunosuppressed patients, the predominant pathologic abnormalities are tissue invasion, abscess formation, and angioinvasion with or without infarction. In this study, we examined cases of invasive pulmonary aspergillosis in one kidney recipient and three liver transplant recipients. All the patients were male, and their mean age was …
Effects Of Increased Respiratory Resistance On Maximal O_2 Uptake And Anaerobic Threshold During Incremental Exercise Tests, Oğuz Özçeli̇k, Rami̇s Çolak
Effects Of Increased Respiratory Resistance On Maximal O_2 Uptake And Anaerobic Threshold During Incremental Exercise Tests, Oğuz Özçeli̇k, Rami̇s Çolak
Turkish Journal of Medical Sciences
This study was undertaken to assess whether maximal O_2 uptake (VO_2max) can be used as an index of measuring aerobic capacity under the condition of increased respiratory resistance. Seven male subjects performed two incremental exercise tests on a cycle ergometer on different days: one control (C) and one breathing through an 8 mm bore diameter respiratory resistance (R). Ventilatory and gas exchange responses were measured with a turbine volume transducer and mass spectrometry, and processed breath-by-breath. VO_2max was measured and anaerobic threshold (AT) was estimated non-invasively using the V-slope method. Maximal exercise performance was reduced significantly (by paired t-test, P
A Rare Case Of Neonatal Hypotonia: Neonatal Nonketotic Hyperglycinemia, Ayhan Taşteki̇n, Rahmi̇ Örs, Behzat Özkan, Orhan Deni̇z
A Rare Case Of Neonatal Hypotonia: Neonatal Nonketotic Hyperglycinemia, Ayhan Taşteki̇n, Rahmi̇ Örs, Behzat Özkan, Orhan Deni̇z
Turkish Journal of Medical Sciences
Hypotonia is a serious physical finding in a newborn infant. Nonketotic hyperglycinemia (NKH) is a rare cause of neonatal hypotonia. It is a defect of the glycine metabolism and has poor prognosis. We report a case of a newborn infant with NKH, presented with mild hypotonia and high creatine kinase values. NKH should be considered in a hypotonic newborn, especially if associated with acute deterioration, lethargy and seizures.
Congenital Pseudoarthrosis Of The Clavicle With Multiple Vertebral Anomalies, Ahmet Yi̇ği̇t Göktay, Mustafa Seçi̇l, Erki̇n Çeti̇nkol, Di̇nç Özaksoy
Congenital Pseudoarthrosis Of The Clavicle With Multiple Vertebral Anomalies, Ahmet Yi̇ği̇t Göktay, Mustafa Seçi̇l, Erki̇n Çeti̇nkol, Di̇nç Özaksoy
Turkish Journal of Medical Sciences
ğit GÖKTAY Mustafa SEÇİL Erkin ÇETİNKOL Dinç ÖZAKSOY Department of Radiology, Faculty of Medicine, Dokuz Eylül University, İzmir - TURKEY
Production And Purification Of Monoclonal Antibodies To Human Interleukin-2 And Their Use For Immunoaffinity Purification Of Recombinant Human Interleukin-2, Cemaletti̇n Aybay
Production And Purification Of Monoclonal Antibodies To Human Interleukin-2 And Their Use For Immunoaffinity Purification Of Recombinant Human Interleukin-2, Cemaletti̇n Aybay
Turkish Journal of Medical Sciences
Monoclonal antibodies (mAbs) are a powerful immunochemical tool. Today, the availability of mAbs with desired specificity enables ligand separation based upon the immunoaffinity technique. By using the high selectivity of mAbs, immunoaffinity purification offers the possibility of isolating compounds even from complex samples with a selectivity which cannot be achieved by other methods. This paper reports the preparation and identification of monoclonal antibodies against human interleukin-2 (IL-2) and the establishment of an immunoaffinity method for purifying human IL-2 (hIL-2). Hybridomas were generated by the fusion of NSO or FO myelomas and spleen cells from immunized mice. Hypoxanthine-aminopterin-thymidine-resistant hybridomas secreting antibodies …
The Relation Between Low-Density Lipoprotein (Ldl) Oxidation And Hemodialysis With Respect To Membrane Types Protective Effects Of Vitamin E-Bonded Membrane, Selda Demi̇rtaş, Gökhan Nergi̇soğlu, Ayşegül Akbay Yarpuzlu, Levent Karaca
The Relation Between Low-Density Lipoprotein (Ldl) Oxidation And Hemodialysis With Respect To Membrane Types Protective Effects Of Vitamin E-Bonded Membrane, Selda Demi̇rtaş, Gökhan Nergi̇soğlu, Ayşegül Akbay Yarpuzlu, Levent Karaca
Turkish Journal of Medical Sciences
Plasma total antioxidant (TAO) levels, LDL (low density lipoprotein), antioxidant defense potential (AOP) and the resistance to oxidation of LDL fractions were studied in chronic hemodialysis patients. The differences with respect to dialyzer membrane types before and after hemodialysis were also assessed. After isolation of LDL from plasma by precipitation, AOP was measured based on the determination of TBARS (thiobarbituric acid reactive substance), and resistance to oxidation was assessed by the metal-catalyzed peroxidation of LDL followed by the determination of the values of the peroxidation product malondialdehide (MDA) before and after peroxidation. The assay principle of TAO was based on …
Effect Of Low Dietary Zinc Intake And Experimental Diabetes On The Zinc And Carbohydrate Metabolism In Rats, Zine Kechrid, Nazan Demi̇r, Cherif Abdennour, Noureddine Bouzerna
Effect Of Low Dietary Zinc Intake And Experimental Diabetes On The Zinc And Carbohydrate Metabolism In Rats, Zine Kechrid, Nazan Demi̇r, Cherif Abdennour, Noureddine Bouzerna
Turkish Journal of Medical Sciences
To investigate the effect of low dietary zinc intake and experimental diabetes (IDDM) on the zinc and carbohydrate metabolism, 8-week-old male wealing normal albino (Wistar) rats were fed diets containing either adequate (54mg/kg) or low zinc (1mg/kg) quantities for one week. Ten rats from each group (n=20) were then intraperitoneally injected with alloxan to induce diabetes. The rats were sacrificed after a further three weeks. Body weight gain and food intake were recorded regularly. On day 28, after an overnight fast, the animals were sacrificed and blood glucose, serum insulin, serum cholesterol concentrations, liver glycogen contents, and femur and pancreatic …
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Turkish Journal of Medical Sciences
The aim of this study was to determine the histological changes of the thoracic aorta in rats fed on alcohol for a period of 24 weeks. Twenty male Wistar rats were divided into two groups. The ethanol group (n=10) was fed on a modified liquid diet (MLD) containing 7.2% ethanol for 24 weeks. The control group (n=10) was fed on MLD without ethanol throughout the experiment. At the end of the 24 weeks, the carotid arteries of the rats were cannulated and their blood pressures were measured. Ethanol levels measured by using the NAD+/NADH enzyme-spectrophotometric method. Rats were killed by …
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Turkish Journal of Medical Sciences
The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically. The tissues (tumoral and adjacent tumor-free tissue) that were obtained during surgery were labeled with ^3H-Thymidine. TLI was calculated as the number of labeled tumor cells * 100 / total number of tumor cells. A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and …
Centromeric Smn Deletions In Various Congenital Muscular Dystrophies, Hayat Erdem Yurter, Di̇dem Dayangaç Erden, Saci̇de Pehli̇van, Beri̇l Tali̇m, Haluk Topaloğlu
Centromeric Smn Deletions In Various Congenital Muscular Dystrophies, Hayat Erdem Yurter, Di̇dem Dayangaç Erden, Saci̇de Pehli̇van, Beri̇l Tali̇m, Haluk Topaloğlu
Turkish Journal of Medical Sciences
We studied centromeric SMN gene deletions in various forms of congenital muscular dystrophies. Our study cohort consisted of 48 patients (43 families): 24 with merosin-positive CMD, 18 with merosin-deficient CMD and 6 with muscle-eye-brain (MEB) disease. None of the patients showed deletions of the telomeric gene; however, the deletion frequency of the centromeric gene was 27%. In a multiplex family, the mildly affected sibling, who is ambulant, had a preserved centromeric copy of the SMN gene, whereas in the severely affected sibling the copy was missing. The centromeric copy of the SMN gene may have a contributing role in the …
Causes And Effective Factors On Mortality Of Intestinal Obstruction In The South East Anatolia, Yilmaz Akgün, Gülşen Yilmaz, Hasan Akbayin
Causes And Effective Factors On Mortality Of Intestinal Obstruction In The South East Anatolia, Yilmaz Akgün, Gülşen Yilmaz, Hasan Akbayin
Turkish Journal of Medical Sciences
Mechanical intestinal obstruction is a common problem confronting the surgeon. The clinical records of 699 patients surgically treated for intestinal obstruction were evaluated retrospectively and factors affecting mortality in these patients were investigated. There were 202 (28.9%) women and 497 (71.1%) men, with a median age of 48.5±19.4 years involved in the study. Volvulus formed the vast majority of cases (28.6%), followed by adhesions (25.3%), strangulated hernias (24.0%) and malignancy (16.8%). Although strangulated hernias and malignancy might occur at any age, the peak incidence for causes of obstruction due to adhesions (55.9%) was in the 15-34 age group, and volvulus …
A Cadaveric Polycystic Kidney Donor, Tanju Acar, Mahmood Arshad
A Cadaveric Polycystic Kidney Donor, Tanju Acar, Mahmood Arshad
Turkish Journal of Medical Sciences
AR Mahmood ARSHAD Department of Renal Transplantation, Guy's and St Thomas Hospital, London - UK
Ifn-G-Mediated Transcriptional Induction Of The Ido (Indolamine 2,3-Dioxygenase) Gene Requires Activity Of P68/Pkr Protein Kinase, Ni̇lüfer Gülmen İmi̇r, Ayşegül Nasircilar, Hakan Akça, Teki̇nalp Gelen, Mehmet Öğüş, Şeyda Karaveli̇, Osman Ni̇dai̇ Özeş
Ifn-G-Mediated Transcriptional Induction Of The Ido (Indolamine 2,3-Dioxygenase) Gene Requires Activity Of P68/Pkr Protein Kinase, Ni̇lüfer Gülmen İmi̇r, Ayşegül Nasircilar, Hakan Akça, Teki̇nalp Gelen, Mehmet Öğüş, Şeyda Karaveli̇, Osman Ni̇dai̇ Özeş
Turkish Journal of Medical Sciences
We investigated whether the activity of double-stranded RNA activated kinase (p68/PKR) is necessary for induction of IDO (indolamine 2,3 -dioxygenase) gene by IFN-\gamma. For this purpose, we planned to abrogate the function of cellular wt-PKR gene. Clones of ME180 cells expressing the dominant negative form of PKR were selected in the presence of neomycin. Then these cells were treated with IFN-\gamma and accumulation of IDO protein was determined by Western blot analysis. We found that clones expressing the dominant negative form of the PKR gene were not only resistant to IFN-\gamma-mediated killing, but were also incapable of inducing accumulation of …
Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark
Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark
Turkish Journal of Medical Sciences
LAN Volkan ÜLKER Necla ÜLKER Neslihan YEREBASMAZ Cemal ARK Department of Perinatology, SSK Bakırköy Maternity and Children Hospital, İstanbul, Turkey
Autotransplantation Of A Kidney Due To Retroperitoneal Fibrosis, Tanju Acar, Mahmood Arshad
Autotransplantation Of A Kidney Due To Retroperitoneal Fibrosis, Tanju Acar, Mahmood Arshad
Turkish Journal of Medical Sciences
AR Mahmood ARSHAD Guy's & St Thomas Hospital, Renal Transplantation Department, London, United Kingdom
Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan
Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan
Turkish Journal of Medical Sciences
YKARA^1 Nuri ERDOĞAN^1 Mustafa ÖZTÜRK^1 Mustafa ERKAN^2 Departments of ^1Radiology, ^2Otorhinolaryngology, Faculty of Medicine, Erciyes University, Kayseri - Turkey