Medicine and Health Sciences Commons^™

A Decentralized, Patient-Centered Approach To Diabetes Disease Management In The Primary Care Setting, Michael Toscani, John P. O'Connor, David B. Nash

College of Population Health Faculty Papers

Although many disease management programs have been developed for diabetes, no single design has proved best for all providers and patient populations. Cost effectiveness is especially relevant to diabetes programs because significant costs of the disease may come from complications that occur later in life, while the costs of the program are incurred immediately. For this reason, diabetes disease management programs with positive outcomes and low implementation costs are of particular importance. We report here on the outcomes of a pilot test of the Steps to Health program developed by Abbott Laboratories. The Steps to Health program was designed to …

Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor

Dartmouth Scholarship

Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. Recent studies on the molecular nature of the virulence components that contribute to V. cholerae pathogenesis have provided insights into possible approaches for the development of a defined subunit cholera vaccine. Genetic analysis has demonstrated that the toxin-coregulated pilus (TCP) is the major factor that contributes to colonization of the human intestine by V. cholerae. In …

Immune Response Genes Modulate Serologic Responses To Vibrio Cholerae Tcpa Pilin Peptides, Michael D. Meeks, Terri K. Wade, Ronald K. Taylor, William F. Wade

Dartmouth Scholarship

Cholera is an enteric disease caused by Vibrio cholerae. Toxin-coregulated pilus (TCP), a type 4 pilus expressed by V. cholerae, is a cholera virulence factor that is required for host colonization. The TCP polymer is composed of subunits of TcpA pilin. Antibodies directed against TcpA are protective in animal models of cholera. While natural or recombinant forms of TcpA are difficult to purify to homogeneity, it is anticipated that synthesized TcpA peptides might serve as immunogens in a subunit vaccine. We wanted to assess the potential for effects of the immune response (Ir) gene that could complicate a peptide-based …

Characterization Of Seca-Sod Operon In Borrellia Burgdorferi., Tonya Lynn Nichols

Electronic Theses and Dissertations

Borrelia burgdorferi, the causative agent of Lyme disease, has been characterized as a microaerophilic spirochete. O2 consumption and utilization potentially yield reactive oxygen intermediates, such as superoxide, hydroxyl radicals, and hydrogen peroxide. This study investigated the expression of the sod gene, which encodes the only, identified oxidative defense mechanism in B. burgdorferi. Using primer extension analysis and RT-PCR, it was found that sod and secA are organized as a single transcriptional unit under the control of σ70-like promoter upstream of the secA open reading frame. Generally, gene expression decreases with increased distance from the promoter; however, secA expression was observed …

Integrated Nursing Practice: The Outlying Areas Of Thailand"Improvement Of Maternal And Child Health Carein Northeast Thailand: The Isaan Initiative", P. Chaiphibalsarisdi, D. Huddleston, S. Egoramaiphol, P. Shawong

Chulalongkorn Medical Journal

No abstract provided.

Behavioral Changes In Adult C57bl/6j Mice Following Prenatal Exposure To Ethanol., Kevin Wade Nunley

Electronic Theses and Dissertations

Fetal Alcohol Syndrome (FAS) labels children with physical, mental and behavioral deficits exposed to alcohol in utero. Current research indicates that timing of alcohol exposure of the embryo/fetus is a critical determinant of the behavioral deficits associated with FAS. This study represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were …

Prognostic Impact Of P53 Status, Tls-Chop Fusion Transcript Structure, And Histological Grade In Myxoid Liposarcoma: A Molecular And Clinicopathologic Study Of 82 Cases, C. R. Antonescu, S. J. Tschernyavsky, R. Decuseara, Denis H. Y. Leung, J. M. Woodruff, M. F. Brennan, J. A. Bridge, J. R. Neff, J. R. Goldblum, M. Ladanyi

Research Collection School Of Economics

Purpose: A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS). Three common forms of the TLS-CHOP fusion have been described, differing by the presence or absence of TLS exons 6-8 in the fusion product. Type 5-2 (also known as type II) consists of TLS exons 1-5 fused to CHOP exon 2; type 7-2 (also known as type I) also includes TLS exons 6 and 7 in the fusion, whereas type 8-2 (also known as type III) fuses TLS exons 1-8 to CHOP exon 2. We sought to determine the impact …

The Relationship Between Acculturation Level And Patient Satisfaction Among Adult Mexican American Emergency Department Patients, Sharon M. Schaaf

Theses and Dissertations - UTB/UTPA

The relationship between acculturation level and patient satisfaction among adult Mexican American emergency department patients was explored. Acculturation level was determined by the Acculturation Rating Scale for Mexican Americans-II (ARSMA-II). Patient satisfaction was measured with the Patient Satisfaction Inventory (PSI). The study was conducted in an emergency department in the Lower Rio Grande Valley of South Texas, where 23 participants provided the data. The questionnaires were offered in English and Spanish. The independent variable of acculturation level did not demonstrate a significant relationship with the dependent variable of patient satisfaction. A statistically significant difference was identified among the subscales of …

Using An Importance-Performance Analysis Of Summer Students In The Evaluation Of Student Health Services., Candice Cline Duvernois

Electronic Theses and Dissertations

Hitherto, students have not evaluated the importance and performance of services provided by the student health service (SHS) at East Tennessee State University. An evaluation could provide valuable feedback to providers and administration.

In 2001, there were 944 student visits in the summer sessions. Approximately 256 students were offered a survey containing an Importance-Performance scale of which 151 (59.0%) responded. The I-P scale rates the importance students place on healthcare services and the performance of the SHS in delivering services (i.e., patient satisfaction).

Based on mean scores, students reported high importance, high performance on urgent care, pharmacy and patient education. …

Antibody Titres In Broilers Of Infectious Bronchitis Virus Strains 4/91 And Massachusetts In Thailand, Thawat Lekdumrongsak, Jiroj Sasipreeyajan, Prachak Poomvises, Achara Tawatsin

The Thai Journal of Veterinary Medicine

Thirty, one-day-old broilers were divided into 3 groups, 10 birds each. Group 1 was vaccinated twice with a live infectious bronchitis virus vaccine, (IBV)-serotype Massachusetts, strain H120 when one day old and a live IBV-strain Massachusetts vaccine when ten days old. Group 2 was vaccinated once with a live IBV-strain Massachusetts vaccine when ten days old. Group 3 were non-vaccinated controls. Blood samples were taken from birds on days 1, 10, 21, 28, 35 and 42. Samples were tested by a virus neutralization(VN) test, for strains 4/91 and Massachusetts(M41) neutralizing antibodies and were tested by an enzyme-linked immunosorbent assay(ELISA) for …

Immunohistochemical Detection Of Feline Viral Rhinotracheitis In A Cat, Nopadon Pirarat, Yumi Une, Yasuo Nomura

The Thai Journal of Veterinary Medicine

A female, 10-month old, mixed breed cat showed clinical signs of severe dehydration, purulent nasal discharge, dyspnea, severe crepitating lung sounds and no response to antibiotic treatment. Upon necropsy, histopathology revealed severe, diffuse, fibrinopurulent pleuropneumonia and numerous, homogeneous, amphophilic, intranuclear inclusion bodies in the pulmonary alveolar macrophages, bronchial and alveolar epithelium and bronchial glandular epitheliums. Immunohistochemical studies using 3 different monoclonal, anti-Feline Herpesvirus type 1 antibodies, revealed immunoreactivity of viral antigen in the lung that was associated with the histopathological changes. Monoclonal, anti-glycoprotein B, antibody showed the strongest immunoreactivity.

Rumination And Cigarette Smoking: A Bad Combination For Depressive Outcomes?, Malia Richmond, Bonnie Spring, Beth Kaplan Sommerfeld, Dennis E. Mcchargue

Department of Psychology: Faculty Publications

Ruminative coping has been shown to heighten the risk and severity of depression. The authors hypothesized that ruminators who smoke would experience greater depressive symptoms than ruminators who do not. The rationale is that, by heightening attentional focus, nicotine may increase ruminators' ability to focus on negative thoughts, augmenting depressed mood. Participants (N = 145) self-reported smoking status, rumination, and current and lifetime depressive symptoms, including depressed mood. Results showed that rumination accounted for a larger amount of variance in current and past depressed mood and severity of lifetime depressive symptoms among smokers than nonsmokers. Noncorrelational, experimental research should …

Long-Term Outcome Of Gastrostomy Feeding In Dysphagic Stroke Patients, Tung-Chou Li, Mei-Hue Hsu, Tzong-Hsi Lee

Rehabilitation Practice and Science

Dysphagia is a common reason for long-term enteral feeding in stroke patients. It has been shown that gastrostomy feeding provides better nutrition for stroke patients than nasogastric tube feeding in short term period. However, little is known about the long-term outcome of gastrostomy-assisted feeding in them. In recent years, some of the dysphagic stroke patients began to accept gastrostomy feeding in Taiwan. We herein conducted this study to find and analyze the characteristics and long-term outcome of dysphagic stroke patients who had underwent gastrostomy. Forty-two stroke patients underwent gastrostomy between Jan. 1998 and May 2000 were enrolled in this study. …

Inside Unlv, Diane Russell, Jennifer Vaughan, Richard Jensen, Mae Worthey-Flennoy

Inside UNLV

No abstract provided.

A Design Of Rehabilitation Information System For Inpatients: An Experience Of A Medical Center, Mu-Jung Kao, Chih-Tsung Hsieh, Rong-Lin Yang, Mei-Wun Tsai

Rehabilitation Practice and Science

Rehabilitation Information System for Inpatients (RISI) was designed for medical administration in the Department of Rehabilitation at a medical center in Taiwan. The RISI includes administration system, patient consultation system, rehabilitation order entry system, rehabilitation therapy system for physical therapy, occupational therapy, and speech therapy, check out system for time and frequency of therapy, and statistic function system.The characteristics of this system includes: 1) integration of systems between outpatients and inpatients; 2) integration of available administration system and patient consultation system; 3) integration of administration and medical system in the department of rehabilitation and 4) operation without paper work. The …

The Interaction Between Antidepressants And Spasticity Of Stroke: Casereport, Shih-Wen Lin, Zong-Jing Wang, Young-Hue Yu

Rehabilitation Practice and Science

The upper motor neuron diseases (such as cerebrovascular accidents, traumatic brain injury, spinal cord injury, and multiple sclerosis) frequently cause spasticity of extremities. The medications for treating spasticity include baclofen and diazepam, which take their effect in the central nervous system through their GABAergic action. The incidence of depression in patients with spasticity is much higher than that of the normal population. Many doctors prescribe antidepressants for these patients. Two common used antidepressants are tricyclic antidepressants (TCA) and selective serotonin reuptake inhibitors (SSRI). They could increase serotonin amount in synapses, and induce increased excitability of motor neurons, which in turn …

Anti-Class Ii Monoclonal Antibody-Targeted Vibrio Cholerae Tcpa Pilin: Modulation Of Serologic Response, Epitope Specificity, And Isotype, Jia-Yan Wu, Ronald K. Taylor, William F. Wade

Dartmouth Scholarship

Toxin-coregulated pilus (TCP) is a colonization factor required for cholera infection. It is not a strong immunogen when delivered in the context of whole cells, yet pilus subunits or TcpA derivative synthetic peptides induce protective responses. We examined the efficacy of immunizing mice with TCP conjugated to anti-class II monoclonal antibodies (MAb) with or without the addition of cholera toxin (CT) or anti-CD40 MAb to determine if the serologic response to TcpA could be manipulated. Anti-class II MAb-targeted TCP influenced the anti-TCP peptide serologic response with respect to titer and isotype. Responses to TcpA peptide 4 were induced with class …

Evaluation Of A Tetracycline-Inducible Promoter In Staphylococcus Aureus In Vitro And In Vivo And Its Application In Demonstrating The Role Of Sigb In Microcolony Formation, B. T. Bateman, N. P. Donegan, T. M. Jarry, M. Palma

Dartmouth Scholarship

An inducible promoter system provides a powerful tool for studying the genetic basis for virulence. A variety of inducible systems have been used in other organisms, including pXyl-xylR-inducible promoter, the pSpac-lacI system, and the arabinose-inducible P_BAD promoter, but each of these systems has limitations in its application to Staphylococcus aureus. In this study, we demonstrated the efficacy of a tetracycline-inducible promoter system in inducing gene expression in S. aureus in vitro and inside epithelial cells as well as in an animal model of infection. Using the xyl/tetO promoter::gfp_uvr fusion carried on a shuttle …

Refugee Experiences Of Trauma And Ptsd Effects On Psychological, Physical, And Financial Well-Being, Karen J. Cusack

Dissertations

No abstract provided.

State Regulations Of Smoking In Public Places: Determinants And Implications On The Demand For Smoking And Consumers' Behavior, Ioana Raluca Mazare

Dissertations

No abstract provided.

Involvement Of Females As Authors, Editors, And Participants In Journals Concerned With Mental Retardation And Related Topics, Cari L. Porter

Dissertations

No abstract provided.

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001 Building a dynamic multicultural community at Jefferson, page 4 Farber institute for neurosciences will be headed by Samuel Gandy, page 7 Dean Thomas Nasca’s strategic plan, page 10 Bud Bacharach’56 receives the cornerstone award, page 18

Factors Influencing Puberty Attainment In Gilts And Policies That Can Improve Mating Efficiency In Replacement Gilts, Padet Tummaruk, Wichai Tantasuparuk, Mongkol Techakumphu, Annop Kunavongkrit

The Thai Journal of Veterinary Medicine

The objective of this study is to review the information regarding the development of puberty in gilts and how it influences subsequent reproductive performance such an understanding can be used to improve mating efficiency in gilts. The percentage of gilts in a herd strongly influences overall productivity. The first management decision that has to be made about gilts entering the breeding herd, is the timing of the first breeding. This largely depends on when puberty develops. Puberty in gilts is defined as the time when the first oestrus and ovulation occurs followed by regular oestrous cycles. On average, gilts attain …

Ecg Quiz, Chollada Buranakarl, Kris Angkanaporn, Sumpun Thammacharoen, Phiwipha Kamonrat

The Thai Journal of Veterinary Medicine

No abstract provided.

What Is Your Diagnosis?, Pranee Tuntivanich

The Thai Journal of Veterinary Medicine

No abstract provided.

Review Of Family Experience With Mental Illness. Richard Tessler And Gail Gamache. Reviewed By James W. Callicutt, James W. Callicutt

The Journal of Sociology & Social Welfare

Book review of Richard Tessler and Gail Gamache, Family Experiences with Mental Illness. Westport, CT: Auburn House, 2000. $19.95 papercover.

Molecular Studies Involving The Rev Protein Of Caprine Arthritis Encephalitis Virus And Visna Virus., Bridget Michele Graves

Electronic Theses and Dissertations

Caprine Arthirtis Encephalitis Virus (CAEV) and Visna Virus are two viruses of the lentivirus family. They encode three structural genes (gag, pol, and env) and two regulatory genes (rev and tat). The Rev protein regulates Gag, Pol and Env expression by transporting their mRNAs to the cytoplasm by binding to the RRE (Rev Response Element) found on their mRNAs. Previous studies have indicated that Rev may be toxic to transfected cells, overexpression of exogenous RREs or a better binding RRE can inhibit Rev activity and Rev-C (CAEV Rev) can trans-activate RRE-V (Visna Virus …

Genital Tract Lesions And The Isolation Of Ureaplasma Diversum From The Reproductive Tract Of Normal And Repeat Breeding Dairy Cows, Prachin Virakul, Kraiwan Hongyantarachai, Kitti Mahaviroon, Saroch Ngarmkum, Phornchai Suwannaphirom, Vinai Krasaesinthugomol, Ayuth Harintharanont, Santi Prasithphol, Pairoj Ampawanwong, Junpen Suwimonteerabutr

The Thai Journal of Veterinary Medicine

This study was conducted in 78 dairy cows(50 repeat breeders and 28 normal cows, with no history of breeding difficulty) from 6 livestock regions of Thailand. Observations were made on the lesions of granular vulvitis and bacteriology performed in order to isolate Ureaplasma diversum. Swabs were taken from 3 sites; the clitoral fossa, the dorsal vulva lips and the external cervical osteum. The isolation of U. diversum was carried out using Taylor Robinson Medium. In the repeat breeding group, U. diversum was isolated from 46% of the clitoral swabs, 48% of the vulva lip swabs and 22% of the external …

Ultrasound Diagnosis, Phiwipha Kamonrat

The Thai Journal of Veterinary Medicine

No abstract provided.

From Product Dispensing To Patient Care: The Role Of The Pharmacist In Providing Pharmaceutical Care As Part Of An Integrated Disease Management Approach, Laura T. Pizzi, Jean M. Menz, Geneen R. Graber, Dong-Churl Suh

College of Population Health Faculty Papers

During the past decade, the profession of pharmacy has changed dramatically. The Doctor of Pharmacy degree has replaced the Bachelor of Science degree as the first professional degree offered at most accredited U.S. pharmacy schools. Advanced clinical training is now a mainstay of pharmacy training, and this has enabled pharmacists to contribute to disease management efforts. In addition, technological improvements in prescription processing have afforded pharmacists more time to participate in disease management activities. This paper describes how the role of the pharmacist has changed and reviews the results of programs involving pharmacists as disease management providers in the areas …