Medicine and Health Sciences Commons^™

Anti-Class Ii Monoclonal Antibody-Targeted Vibrio Cholerae Tcpa Pilin: Modulation Of Serologic Response, Epitope Specificity, And Isotype, Jia-Yan Wu, Ronald K. Taylor, William F. Wade

Dartmouth Scholarship

Toxin-coregulated pilus (TCP) is a colonization factor required for cholera infection. It is not a strong immunogen when delivered in the context of whole cells, yet pilus subunits or TcpA derivative synthetic peptides induce protective responses. We examined the efficacy of immunizing mice with TCP conjugated to anti-class II monoclonal antibodies (MAb) with or without the addition of cholera toxin (CT) or anti-CD40 MAb to determine if the serologic response to TcpA could be manipulated. Anti-class II MAb-targeted TCP influenced the anti-TCP peptide serologic response with respect to titer and isotype. Responses to TcpA peptide 4 were induced with class …

Evaluation Of Cholera Vaccines Formulated With Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant In Mice, Jia-Yan Wu, William F. Wade, Ronald K. Taylor

Dartmouth Scholarship

Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. Recent studies on the molecular nature of the virulence components that contribute to V. cholerae pathogenesis have provided insights into possible approaches for the development of a defined subunit cholera vaccine. Genetic analysis has demonstrated that the toxin-coregulated pilus (TCP) is the major factor that contributes to colonization of the human intestine by V. cholerae. In …

Rumination And Cigarette Smoking: A Bad Combination For Depressive Outcomes?, Malia Richmond, Bonnie Spring, Beth Kaplan Sommerfeld, Dennis E. Mcchargue

Department of Psychology: Faculty Publications

Ruminative coping has been shown to heighten the risk and severity of depression. The authors hypothesized that ruminators who smoke would experience greater depressive symptoms than ruminators who do not. The rationale is that, by heightening attentional focus, nicotine may increase ruminators' ability to focus on negative thoughts, augmenting depressed mood. Participants (N = 145) self-reported smoking status, rumination, and current and lifetime depressive symptoms, including depressed mood. Results showed that rumination accounted for a larger amount of variance in current and past depressed mood and severity of lifetime depressive symptoms among smokers than nonsmokers. Noncorrelational, experimental research should …

Development Of A Model For Infective Endocarditis Via Intravenous Injection And Tooth Infection Of Rats Using Pathogenic Bacteria, Shahrokh Shabahang

Loma Linda University Electronic Theses, Dissertations & Projects

Historically, focal areas of infection have been linked to a number of systemic ailments. During the early part of the 20th century, patients who were suffering from inexplicable diseases and who were suspected of having infected teeth were referred to the dentist for multiple extraction of their dentition. The discovery of antibiotics provided a false sense of security that the war against microorganisms is no longer a concern for mankind. However, more recently, it has become common belief that increasing numbers of systemic diseases are linked to chronic infections. Recovery of bacteria from representative tissues has led investigators to believe …

Evaluation Of A Tetracycline-Inducible Promoter In Staphylococcus Aureus In Vitro And In Vivo And Its Application In Demonstrating The Role Of Sigb In Microcolony Formation, B. T. Bateman, N. P. Donegan, T. M. Jarry, M. Palma

Dartmouth Scholarship

An inducible promoter system provides a powerful tool for studying the genetic basis for virulence. A variety of inducible systems have been used in other organisms, including pXyl-xylR-inducible promoter, the pSpac-lacI system, and the arabinose-inducible P_BAD promoter, but each of these systems has limitations in its application to Staphylococcus aureus. In this study, we demonstrated the efficacy of a tetracycline-inducible promoter system in inducing gene expression in S. aureus in vitro and inside epithelial cells as well as in an animal model of infection. Using the xyl/tetO promoter::gfp_uvr fusion carried on a shuttle …

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 1, December 2001 Building a dynamic multicultural community at Jefferson, page 4 Farber institute for neurosciences will be headed by Samuel Gandy, page 7 Dean Thomas Nasca’s strategic plan, page 10 Bud Bacharach’56 receives the cornerstone award, page 18

Effect Of Monounsaturated Fat Rich Almonds On Hemostatic And Inflammatory Factors In Healthy Adults, Kristianne M. Connell

Loma Linda University Electronic Theses, Dissertations & Projects

Background: The frequent consumption of nuts is inversely associated with the incidence of cardiovascular disease. Nuts are known to decrease the risk of cardiovascular disease by reducing serum total and low-density lipoprotein (LDL) cholesterol. Markers of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds on markers of inflammation and hemostasis that influence cardiovascular disease risk is not currently known.

Objective: The objective of this study was to determine the effect of almond consumption on markers of inflammation and hemostatic factors in healthy …

A Comparison Of Hot Packs And Light Or Moderate Exercise On Rectus Femoris Temperature, Sean J. Sreniawski

All-Inclusive List of Electronic Theses and Dissertations

Context: Hot packs, light exercise, and or moderate exercise are used to heat soft tissue injuries before rehabilitation or competition for their desired effects. This comparison is beneficial to clinicians, so that they may be better educated on the use of the most effective therapeutic modality heating protocols when treating a soft tissue injury. Objective: To compare the application of a hot pack to light intensity exercise and moderate intensity exercise on peak temperature of the rectus femoris muscle, and the time at which peak temperature is reached. Design: A 1 x 3 factorial design was used in this study. …

Comparison Of Basic Coagulation Test Specimensfrom The Evacuated Blood Collection Systemand The Syringe Blood Collection System, V. Wiwanitkit, W. Huayhongthong, S. Niampia

Chulalongkorn Medical Journal

No abstract provided.

The Relationship Between Acculturation Level And Patient Satisfaction Among Adult Mexican American Emergency Department Patients, Sharon M. Schaaf

Theses and Dissertations - UTB/UTPA

The relationship between acculturation level and patient satisfaction among adult Mexican American emergency department patients was explored. Acculturation level was determined by the Acculturation Rating Scale for Mexican Americans-II (ARSMA-II). Patient satisfaction was measured with the Patient Satisfaction Inventory (PSI). The study was conducted in an emergency department in the Lower Rio Grande Valley of South Texas, where 23 participants provided the data. The questionnaires were offered in English and Spanish. The independent variable of acculturation level did not demonstrate a significant relationship with the dependent variable of patient satisfaction. A statistically significant difference was identified among the subscales of …

Relationship Between Nursing Nutrition Knowledge And Attitudes And Identification Of Malnutrition In The Acute Care Setting, Susan D. Kendziorski

Masters Theses

Malnutrition is widespread in healthcare and effective protocols are needed to identify those at risk. Nurses are well suited to carry out screening for malnutrition because they are in close contact with the patient and are responsible to coordinate each patient's care. In order to perform this role nurses must have nutrition knowledge and the skills to complete an accurate nutrition screen. The purpose of this study was to examine relationships between nursing nutrition knowledge, nursing attitudes towards nutrition, and the accurate completion of a nutrition screening protocol. Patient's charts were reviewed for accurate completion of the nutrition screening protocol …

Dextran-Methylprednisolone Succinate As A Prodrug Of Methylprednisolone: Plasma And Tissue Disposition, Xiaoping Zhang, Reza Mehvar

Pharmacy Faculty Articles and Research

Plasma and tissue disposition of a macromolecular prodrug of methylprednisolone (MP), dextran (70 kDa)–methylprednisolone succinate (DMP), was studied in rats. Single 5‐mg/kg doses of DMP or unconjugated MP were administered into the tail veins of different groups of rats (n  = 4/group/time point). Blood (cardiac puncture) and tissues (liver, spleen, kidney, heart, lung, thymus, and brain) were collected at various times after DMP (0–96 h) or MP (0–2 h) injections. Concentrations of DMP and MP in samples were analyzed by size‐exclusion chromatography (SEC) and reversed‐phase high‐performance liquid chromatography (HPLC), respectively. Conjugation of MP with 70‐kDa dextran resulted in 22‐, …

Parental [Correction Of Perinatal] Consanguinity: A Risk Factor For Developmental Delay In Pakistani Children, S Ibrahim, Z Habib, S Hyder, I S. Azam, R Ahmed

Department of Paediatrics and Child Health

Objective: To investigate the association of parental consanguinity and delayed development in terms of gross motor, fine motor, speech and social aspects in their children.
Methods: One hundred and seventy seven children (age 15 days--72 months) were evaluated for their developmental status utilizing the Denver Developmental Screening Test (DDST). An unmatched case-control study design was used. Case group consisted of 94 children and control group 83 children. Odds ratios were calculated for parental consanguinity and delay in gross and fine motor, speech and social development in their children, for cases and controls, utilizing Binary Multiple Logistic Regression Analysis. Acquired delay …

October - December 2001 Nhrd Quarterly Report, Unm Health Sciences Library & Informatics Center

Native Health Database project records

NHRD quarterly report.

From Product Dispensing To Patient Care: The Role Of The Pharmacist In Providing Pharmaceutical Care As Part Of An Integrated Disease Management Approach, Laura T. Pizzi, Jean M. Menz, Geneen R. Graber, Dong-Churl Suh

College of Population Health Faculty Papers

During the past decade, the profession of pharmacy has changed dramatically. The Doctor of Pharmacy degree has replaced the Bachelor of Science degree as the first professional degree offered at most accredited U.S. pharmacy schools. Advanced clinical training is now a mainstay of pharmacy training, and this has enabled pharmacists to contribute to disease management efforts. In addition, technological improvements in prescription processing have afforded pharmacists more time to participate in disease management activities. This paper describes how the role of the pharmacist has changed and reviews the results of programs involving pharmacists as disease management providers in the areas …

Effect Of Nasa Light-Emitting Diode Irradiation On Wound Healing, Harry T. Whelan, Robert L. Smits, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, David A. Margolis, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Alan F. Philippi, William R. Graf, Brian D. Hodgson, Lisa Gould, Mary Kane, Gina Chen, James Caviness

School of Dentistry Faculty Research and Publications

Objective: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing.

Background Data: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans.

Materials and Methods: In vitro and in vivo …

Breathlessness Descriptors In Patients With Chronic Obstructive Pulmonary Disease Versus Congestive Heart Failure, Adelaide De Souza Caroci

Loma Linda University Electronic Theses, Dissertations & Projects

This cross-sectional descriptive study investigated breathlessness (dyspnea) in stable patients with Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF). The purpose of this study was (a) to characterize the most common terms COPD and CHF patients use to describe their breathing, (b) to identify the frequency of dyspnea in patients with COPD and CHF, and (c) to determine the intensity of dyspnea in these populations.

A purposive sample of 60 patients, 30 with moderate to severe COPD and 30 patients with moderate to severe CHF, met the inclusion criteria and were enrolled in this study. The participants provided …

Effects Of A Serine 364 To Proline Mutation Of The Connexin43 Protein In Transgenic Mice, Chia-Ling Nhan-Chang

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

A Design Of Rehabilitation Information System For Inpatients: An Experience Of A Medical Center, Mu-Jung Kao, Chih-Tsung Hsieh, Rong-Lin Yang, Mei-Wun Tsai

Rehabilitation Practice and Science

Rehabilitation Information System for Inpatients (RISI) was designed for medical administration in the Department of Rehabilitation at a medical center in Taiwan. The RISI includes administration system, patient consultation system, rehabilitation order entry system, rehabilitation therapy system for physical therapy, occupational therapy, and speech therapy, check out system for time and frequency of therapy, and statistic function system.The characteristics of this system includes: 1) integration of systems between outpatients and inpatients; 2) integration of available administration system and patient consultation system; 3) integration of administration and medical system in the department of rehabilitation and 4) operation without paper work. The …

The Research Of Medical Service Quality Evaluation: From The Viewpoint Of Predicting Reclaimed Rate Using Neural Networks, Horng-Jeng Shyu, Chao-Chang Chiu, Pei-Lun Hsu, Meei-Fang Lin

Rehabilitation Practice and Science

The goal of this study was to investigate the subtle interrelationships between the insurance claim’s data and clinic performance of medical institutes. Because the medical claims data increase drastically, the review efforts and processes become rather complex and inefficient. The physicians of review committee should have an enterprise view of the claims.We create the performance indicators from consistent data & meta data established from the clinic performance of medical institutes. We adopted 16 outpatient review indicators. We collected rehabilitation claims in middle branch of NHIB since July 1996 till Feb 1997. The prediction model created using both the neural network …

Long-Term Outcome Of Gastrostomy Feeding In Dysphagic Stroke Patients, Tung-Chou Li, Mei-Hue Hsu, Tzong-Hsi Lee

Rehabilitation Practice and Science

Dysphagia is a common reason for long-term enteral feeding in stroke patients. It has been shown that gastrostomy feeding provides better nutrition for stroke patients than nasogastric tube feeding in short term period. However, little is known about the long-term outcome of gastrostomy-assisted feeding in them. In recent years, some of the dysphagic stroke patients began to accept gastrostomy feeding in Taiwan. We herein conducted this study to find and analyze the characteristics and long-term outcome of dysphagic stroke patients who had underwent gastrostomy. Forty-two stroke patients underwent gastrostomy between Jan. 1998 and May 2000 were enrolled in this study. …

Metastatic Prostate Cancer Associated With Lumbar Compression Fracture And Spinal Stenosis: A Casereport And Literature Review, Shwu-Fen Sun, Jue-Long Wang, Ping-Hong Lai

Rehabilitation Practice and Science

We reported a 72 y/o male who had past history of old L1 compression fracture for 1 year. He suffered from falling down accidentally and was operated under impression of L1 burst fracture with cauda equina syndrome. He could ambulate with walker, but persistent back pain was still complained. Two months after operation, he became paralyzed rapidly in 2 days. Neurological examinations showed decreased motor strength of bilateral lower extremities to grade 0-1/5, sensory deficit below T10 dermatome and bilateral extensor plantar response. X-ray film showed an osteoblastic lesion in T9 vertebra body. Magnetic resonance Imaging (MRI) of thoracic spine …

Etiology And Rehabilitation Effect Of Stroke In Child: A Casereport, Li-Chen Tung, Kwok-Tak Yeung, Chun-Hou Wang, Wen-I Liang, Liu-Ing Bih

Rehabilitation Practice and Science

The incidence of strokes in childhood is 2.5/100,000. Of these, occlusive stroke accounts for 57 to 85 percent, and hemorrhagic stroke accounts for 15 to 51 percent. Occlusive stroke is primarily caused by congenital heart defects, and the principal symptom is acute hemiplegia. Hemorrhagic stroke is caused mostly by abnormalities of blood vessels, and is characterized by headache and loss of consciousness. Compared to adults, children have better collateral circulation and incompletely developed brains. The clinical and recovery courses those in children are different from those of adults. The prognosis and the incidence of stroke recurrence are largely determined by …

Using An Importance-Performance Analysis Of Summer Students In The Evaluation Of Student Health Services., Candice Cline Duvernois

Electronic Theses and Dissertations

Hitherto, students have not evaluated the importance and performance of services provided by the student health service (SHS) at East Tennessee State University. An evaluation could provide valuable feedback to providers and administration.

In 2001, there were 944 student visits in the summer sessions. Approximately 256 students were offered a survey containing an Importance-Performance scale of which 151 (59.0%) responded. The I-P scale rates the importance students place on healthcare services and the performance of the SHS in delivering services (i.e., patient satisfaction).

Based on mean scores, students reported high importance, high performance on urgent care, pharmacy and patient education. …

Molecular Studies Involving The Rev Protein Of Caprine Arthritis Encephalitis Virus And Visna Virus., Bridget Michele Graves

Electronic Theses and Dissertations

Caprine Arthirtis Encephalitis Virus (CAEV) and Visna Virus are two viruses of the lentivirus family. They encode three structural genes (gag, pol, and env) and two regulatory genes (rev and tat). The Rev protein regulates Gag, Pol and Env expression by transporting their mRNAs to the cytoplasm by binding to the RRE (Rev Response Element) found on their mRNAs. Previous studies have indicated that Rev may be toxic to transfected cells, overexpression of exogenous RREs or a better binding RRE can inhibit Rev activity and Rev-C (CAEV Rev) can trans-activate RRE-V (Visna Virus …

Factors Influencing Puberty Attainment In Gilts And Policies That Can Improve Mating Efficiency In Replacement Gilts, Padet Tummaruk, Wichai Tantasuparuk, Mongkol Techakumphu, Annop Kunavongkrit

The Thai Journal of Veterinary Medicine

The objective of this study is to review the information regarding the development of puberty in gilts and how it influences subsequent reproductive performance such an understanding can be used to improve mating efficiency in gilts. The percentage of gilts in a herd strongly influences overall productivity. The first management decision that has to be made about gilts entering the breeding herd, is the timing of the first breeding. This largely depends on when puberty develops. Puberty in gilts is defined as the time when the first oestrus and ovulation occurs followed by regular oestrous cycles. On average, gilts attain …

Antibody Titres In Broilers Of Infectious Bronchitis Virus Strains 4/91 And Massachusetts In Thailand, Thawat Lekdumrongsak, Jiroj Sasipreeyajan, Prachak Poomvises, Achara Tawatsin

The Thai Journal of Veterinary Medicine

Thirty, one-day-old broilers were divided into 3 groups, 10 birds each. Group 1 was vaccinated twice with a live infectious bronchitis virus vaccine, (IBV)-serotype Massachusetts, strain H120 when one day old and a live IBV-strain Massachusetts vaccine when ten days old. Group 2 was vaccinated once with a live IBV-strain Massachusetts vaccine when ten days old. Group 3 were non-vaccinated controls. Blood samples were taken from birds on days 1, 10, 21, 28, 35 and 42. Samples were tested by a virus neutralization(VN) test, for strains 4/91 and Massachusetts(M41) neutralizing antibodies and were tested by an enzyme-linked immunosorbent assay(ELISA) for …

Genital Tract Lesions And The Isolation Of Ureaplasma Diversum From The Reproductive Tract Of Normal And Repeat Breeding Dairy Cows, Prachin Virakul, Kraiwan Hongyantarachai, Kitti Mahaviroon, Saroch Ngarmkum, Phornchai Suwannaphirom, Vinai Krasaesinthugomol, Ayuth Harintharanont, Santi Prasithphol, Pairoj Ampawanwong, Junpen Suwimonteerabutr

The Thai Journal of Veterinary Medicine

This study was conducted in 78 dairy cows(50 repeat breeders and 28 normal cows, with no history of breeding difficulty) from 6 livestock regions of Thailand. Observations were made on the lesions of granular vulvitis and bacteriology performed in order to isolate Ureaplasma diversum. Swabs were taken from 3 sites; the clitoral fossa, the dorsal vulva lips and the external cervical osteum. The isolation of U. diversum was carried out using Taylor Robinson Medium. In the repeat breeding group, U. diversum was isolated from 46% of the clitoral swabs, 48% of the vulva lip swabs and 22% of the external …

Immunohistochemical Detection Of Feline Viral Rhinotracheitis In A Cat, Nopadon Pirarat, Yumi Une, Yasuo Nomura

The Thai Journal of Veterinary Medicine

A female, 10-month old, mixed breed cat showed clinical signs of severe dehydration, purulent nasal discharge, dyspnea, severe crepitating lung sounds and no response to antibiotic treatment. Upon necropsy, histopathology revealed severe, diffuse, fibrinopurulent pleuropneumonia and numerous, homogeneous, amphophilic, intranuclear inclusion bodies in the pulmonary alveolar macrophages, bronchial and alveolar epithelium and bronchial glandular epitheliums. Immunohistochemical studies using 3 different monoclonal, anti-Feline Herpesvirus type 1 antibodies, revealed immunoreactivity of viral antigen in the lung that was associated with the histopathological changes. Monoclonal, anti-glycoprotein B, antibody showed the strongest immunoreactivity.

Ecg Quiz, Chollada Buranakarl, Kris Angkanaporn, Sumpun Thammacharoen, Phiwipha Kamonrat

The Thai Journal of Veterinary Medicine

No abstract provided.