Medicine and Health Sciences Commons^™

Update - December 1999, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- John and Alice Wong establish bioethics endowment
-- Richard Rice receives Templeton Award
-- "Humans" and "Persons" in Christian Bioethics (Commentary)
-- Mechanically Restraining the Ill and Elderly: Ethical Problems and Proposals
-- Clinical Ethics Consultation
-- Learn to minister in the clinical setting

The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright

Loma Linda University Electronic Theses, Dissertations & Projects

Within the retina, the POU domain of transcription factors brn-3.0, brn-3.1, and brn-3.2 are present only in retinal ganglion cells. These genes are believed to be involved in establishing neural cell lineages in mammals. In this study brn-3.2 was examined by comparing the number of ganglion cells present during postnatal development in normal mice (+/+), in mice homozygous (-/-) for the brn-3.2 gene, and in adult mice with a heterozygous gene deletion (+/-) for brn-3.2. Optic nerve cross sections were imaged by electron microscopy, and axon profiles counted systematically by hand. These counts were then related to the nerve cross …

A Preclinical Model Of Ionizing Radiation And Tnf-Alpha Gene Therapy For Cancer, Jun Li

Loma Linda University Electronic Theses, Dissertations & Projects

Long term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. This study sought to determine if pretreatment with plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity in vivo, lesser toxicity and relatively low cost. We have constructed a plasmid-based mammalian expression vector (pGL1-TNF) to secrete human TNF-α from cancer cells. Plasmid DNA was successfully transfected into C6 cells …

Family And Child Psychosocial Functioning Of Infant Heart Transplant Recipients, Kimberly R. Freeman

Loma Linda University Electronic Theses, Dissertations & Projects

With the advancement of medical procedures, heart transplantation has become a viable alternative for infants born with congenital or acquired heart disease. Although these children are thought to experience much improvement in their overall physical functioning post-transplantation, the long-term psychological functioning of these children and their families is currently unknown. This study examines the long-term family functioning and psychosocial development of infant heart transplant recipients in comparison to children with congenital heart disease (CHD) and non-clinical control children. Results indicate that infant heart transplant recipients and their families experience fewer overall problems as compared to the CHD group, and more …

Update - September 1999, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Christianity and Contraception: Seventh-day Adventist Ethical Guidelines
-- Can Christian Bioethics be Based on Reason Alone?

Predicting Aggression And Stress In Law Enforcement Using The Mmpi : A Vulnerability Hypothesis, Byron Earle Greenberg

Loma Linda University Electronic Theses, Dissertations & Projects

This study addresses the use of scales and subscales from prehire MMPI’s to predict levels of aggression and stress among law enforcement professionals in the field (n=75). Multiple regression analysis revealed promising results in support of the MMPI’s predictive utility.

Two scales, Aggression (AGR) and Stress Vulnerability (SYS) were developed as outcome measures through a three step validation process: (a) theoretical-substantive, through a literature review and analysis of pilot data (n = 202); (b) internal-structural, statistical analysis on sample data and (c) criterion-external, through corelational analysis with externally derived departmental assessments of each officer. The final Aggression index (AGR) is …

Various Presentation Styles For Informing Parents About Pediatric Dental Procedures, Tracy Dean Walker

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The treatment of pediatric dental patients can only be as effective as the degree to which the parent consents to treatment. This study was designed to A) determine the most effective method of communicating a dental procedure to the parent of a pediatric patient and B) determine the impact that various presentation methods would have on a parent's willingness to give informed consent.

Methods: A Pulpotomy procedure was explained to each parent by one of the following methods; 1) written, 2) written and model, 3) verbal or 4) verbal and model.

Results: A statistically significant relationship was shown between …

Clinical Debonding Simulation Study Of One Metal And Two Ceramic Brackets, Hyunsup Shim

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to compare two mechanical debonding methods on ceramic brackets (TP MXi and 3M Clarity) and a metal bracket (GAC OmniArch) with four different bonding materials (light-cured, one-step chemical-cured, two-step chemical-cured, and Fuji GIC) in clinical simulation, where the diametral force was applied on the handle of the pliers. The effectiveness of mechanical debonding technique was determined by evaluating the following variables: the amount of force required to debond the bracket, the amount of residual adhesive remaining on the enamel surface, the frequency of unexpected bracket failure, and the prevalence of visible enamel damage. The …

The Effect Of Mandibular First Molar Tip Back On Mandibular Incisor Long-Term Stability, Barton L. Soper

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to determine if mandibular first molar distal tip back during orthodontic treatment will result in improved long-term alignment of mandibular incisors. Our pre and posttreatment sample consisted of 57 Class I and Class II patients (40 female and 17 male). Incisor irregularity was recorded at T2 and T4 (average of 12.9 years postretention at T4). Molar tipback was evaluated T1 to T2 and T2 to T4. The sample was divided into 3 groups - molars tipped distally 1 degree or more during treatment, molars essentially not tipped, and molars tipped mesially 1 degree or …

Regulation Of Connexin43 By Phosphorylation, Maithili M. Shah

Loma Linda University Electronic Theses, Dissertations & Projects

Gap junctions play a crucial role in embryogenesis, especially of the heart where connexin43 is thought to be important for its formation as well as synchronized contraction. Several reports have shown that connexin43 protein is phosphorylated on serine residues in vitro and in vivo.

Studies performed in our laboratory have demonstrated that cell-to-cell communication in cells expressing connexin43 can be controlled rapidly and reversibly by microinjection of active protein kinases or phosphatases that target serine or threonine residues. Phosphorylation by cAMP-dependent protein kinase (PKA) seems to favor channel opening, whereas the effect of protein kinase C (PKC) on channel gating …

Neuronal And Metabolic Increases In Pedunculopontine Nucleus Of Parkinson's Rats, Jonathan Dennis Carlson

Loma Linda University Electronic Theses, Dissertations & Projects

The theoretical mechanisms underlying the symptoms of Parkinson’s disease are based on dysfunctional output from the basal ganglia projected to the cortex via the thalamus. However, the subthalamic nucleus (STN) and substantia nigra pars reticularis (SNr) as part of the basal ganglia, also project to the brainstem, in particular to the pedunculopontine nucleus (PPN). Both the STN and SNr have altered neuronal activity in the 6-hydroxydopamine (6-OHDA) Parkinson’s model rat. Thus, it is hypothesized that the PPN is altered in this model of Parkinson’s disease.

This hypothesis was examined by comparing the rates of glucose metabolism and spontaneous neuronal activity …

Loma Linda Nurse - Vol. 08, No. 01, Loma Linda University School Of Nursing

Loma Linda Nurse

Contents

2 | A message from the dean

4 | Research...coming of age

8 | International nursing

10 | Friends...make a difference

11 | 1996 to 1997 Donor Report

21 | 1997 to 1998 Donor Report

30 | H.O.T. report

31 | Alumni president's message

32 | Alumni Homecoming Weekend

36 | Near and far

Commencement Program 1999, Loma Linda University

Commencement Programs

CONTENTS

2 | 1999 Events of Commencement

3 | The Academic Procession

4 | The Speakers

9 | The University Honorees

15 | The School Honorees

The Programs

• School of Medicine, 23
• School of Dentistry, 30
• Graduate School, 38
• School of Nursing, 47
• School of Allied Health Professions - Physical Therapy, 52
• School of Allied Health Professions, 58
• School of Public Health, 65

Update - June 1999, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- February conference will examine future of faith-based health care
-- Stephen G. Post and the Debatable Demise of Dualism
-- A Tale of Two Physicians

Recidivism Among Jamaican Teenage Mothers : A Historical Cohort Study 1995-1998, Vonna Lou Caleb Drayton

Loma Linda University Electronic Theses, Dissertations & Projects

Pregnancy is the single most important reason why girls fail to complete secondary school in the Caribbean. The Women's Centre of Jamaica Foundation (WCJF) Program was established in 1978 to enable adolescent mothers 16 years and under to return to school, and to delay second pregnancies until completion of their education.

This historical cohort study assessed the effect of the WCJF Program on the incidence of repeat pregnancies over the period 1995-1998, and on the educational attainment of program participants. A random sample (n=260) of primiparous Jamaican adolescent mothers 12-16 years who gave birth in 1994 in the parishes of …

The Immunology Of Parturition, Ari Mayer Mackler

Loma Linda University Electronic Theses, Dissertations & Projects

Macrophage-derived factors have been implicated in the etiology of preterm labor but little is known about trafficking of this immune cell into the uterus or its regulation of uterine contractility in mice. Enhanced number and activation of macrophages was hypothesized to precede parturition. Studies characterized contractile activity and the distribution of macrophages in the uterus of C3/HeN mice before and after term (=day 19). Contractile activity by uterine strips on days 15 and 18 of pregnancy, the day of delivery, and 1 day postpartum indicate that an endogenous oscillator sustains high frequency contractions. Modest acceleration of the pacemaker occurred before …

The Validation Of An Existing Sleep Apnea Questionnaire And Its Application To Clinical Orthodontics, Jeffery C. Biggs

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to validate a sleep apnea questionnaire from the Loma Linda University Sleep Disorders Center, and then to utilize the questionnaire in order to identify potential sleep apnea patients from a pre-orthodontic patient sample. Study patients were selected from the Loma Linda University Sleep Disorders Center and the Loma Linda University Orthodontics Clinic, both in Loma Linda, California, USA.

Methods: The study sample represented all of the patients initially examined from 1996 through 1998 who were age 8-15 years old at the time of the initial exam. Validation of the questionnaire was based on responses …

Antitumor Effect Of Il-2, P53, And Bax Naked Gene Transfer In C6 Glioma Cells, Peyman Haghighat

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

Dna-Dna Checkerboard Hybridization To Identify Bacteria In Human Plaque Samples, Jasan Lee Zimmerman

Loma Linda University Electronic Theses, Dissertations & Projects

Previous research has shown that using DNA probes to identify the presence of specific bacteria in human plaque samples is superior to the commonly used anaerobic cultural procedures. Some periodontal pathogens are either uncultivable or very difficult to grow, such as Prevotella intermedia, P. nigrescens, and Eubacterium brachy. Digoxygenin probes were prepared for 15 oral bacteria. These probes were used with a checkerboard DNA-DNA hybridization scheme to analyze whether human plaque samples contained any of the 15 bacterial species. Our results have shown that this method is successful in identifying bacterial DNA present in the subgingival patient plaque …

Patient Participation In Physical Therapy Goal-Setting, Susan M. Baker

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose. An important part of treatment planning in physical therapy is effective goal-setting. The Guide to Physical Therapist Practice recommends that therapists identify the patient’s goals and objectives during the initial evaluation as a way to maximize treatment outcomes. The purpose of this study was to examine whether therapists seek patient participation in goal-setting and, if so, with what methods. We also examined therapists’ attitudes toward participation and patient satisfaction with the evaluation encounter.

Subjects and Methods. Twenty-two physical therapists audiotaped the initial evaluation of 73 elder patients. The audiotaped evaluations were then scored using the Participation …

Diagnosis And Treatment Of Swallowing Dysfunctions : Semg Cognitive Training As An Adjunct To Conventional Therapy, Vicky T. Nguyen

Loma Linda University Electronic Theses, Dissertations & Projects

This study compared surface electromyography (sEMG) cognitive training to conventional myofunctional therapy in controlling a swallowing dysfunction, commonly referred to as "tongue thrust". Nasal airway resistance (NAR) was assessed on every subject, to rule out mechanical obstruction that would prevent proper function. The scope of this investigation composed of evaluating baseline activity and dry swallowing patterns. Subjects were distributed to one of three treatment groups: sEMG cognitive training, conventional myofunctional therapy, and control, based on the degree of NAR (normal, mild, or moderate). Initial sEMG recordings were then taken on subjects that clinically demonstrated a tongue thrust habit to confirm …

Evaluation Of The Effects Of Heat Treatment Using Orthotherm On Thermally Activated Archwires, Brent J. Hurst

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the effects of heat treatment on thermally activated nickel titanium archwires, and to determine the differences between wires from individual manufacturers. Thermally activated, nickel titanium wires were obtained from five different manufacturers in the 0.016 x 0.022 format. All wires were measured with a micrometer to determine their exact dimensions. Half of the wires were heat treated with the use of the Orthotherm Bending Art Programmer from Syrinx Medical Technologies (Berlin, Germany) while the other half served as a control. By passing an electrical current through the wires for a predetermined period …

Effect Of Obturation And / Or Coronal Seal On The Success Of Root Canal Therapy : An In Vivo Histologic Investigation, Douglas Snider

Loma Linda University Electronic Theses, Dissertations & Projects

Numerous studies have examined coronal leakage with in vitro protocols. A search of the literature showed the absence of a long term in vivo, histologic study, examining the effect of coronal and/or radicular leakage on periradicular health.

The purpose of this study was to evaluate the effect of obturation and / or coronal seal in preventing the formation of periradicular lesions in dogs over time. The study was conducted on six beagle dogs. Premolars were cleaned and shaped. Sixteen roots in each dog were randomly assigned to one of four treatment groups of equal size. Group one was obturated using …

Update - March 1999, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Mark Carr, Richard Rice and Siroj Sorajjakool join LLU Faculty of Religion
-- Scholars, Clinicians, and Patients Highlight February Palliative Care Conference
-- [ The Meaning of Pain and Suffering ]
-- MA in Clinical Ethics
-- MA in Clinical Ministry

Marginal Discrepancy Of Components Utilized For Implant Framework Construction, Mathew Thomas Kattadiyil

Loma Linda University Electronic Theses, Dissertations & Projects

This study evaluated marginal fit discrepancy of the abutment-implant body interface employing various components commonly utilized for implant framework fabrication. Four types of components ( castable plastic patterns, premachined gold abutments, premachined titanium abutments and CAD-CAM custom premachined titanium abutments) were evaluated. Five castable plastic patterns and five premachined gold abutme~ts from each of two manufacturers, five premachined titanium abutments and five CAD-CAM custom premachined titanium abutments were used. Components were affixed to a 3.75 x 10 mm dental implant and standardized measurements were obtained of the abutment-implant interface using a computerassisted microscope at various experimental time intervals. Measurements of …

Body Weight And Mortality Among Adults Who Never Smoked, Pramil N. Singh

Loma Linda University Electronic Theses, Dissertations & Projects

Most prospective studies identify an increased mortality risk for adults of high body mass index (> 27 kg/m²) that is commonly attributed to the effects of excess body fat, and also identify an increased mortality risk for adults of low body mass index (< 21 kg/m²), an association that, if causal among healthy adults, is without adequate pathophysiologic support.

In this dissertation, I have conducted three studies that continue the investigation of adiposity in relation to mortality among never-smoking adults of the California Seventh-day Adventist population. Among never-smoking adults of the Adventist Mortality Study (1960-1985), the relation between …

The Association Of Fluid Intake With Total Natural-Cause Mortality, Coronary Heart Disease And Fatal Stroke, Jacqueline Chung Lun Chan

Loma Linda University Electronic Theses, Dissertations & Projects

Hypohydration may be more widespread than realized since it does not always arouse a sense of thirst. When thirst is felt, it is often ignored, or satisfied before euhydration is achieved. There is growing evidence indicating that hypohydration contributes to acute and chronic illnesses, and to rheological factors associated with coronary heart disease (CHD) and stroke. Therefore the relationship of fluid intake with risk of total natural-cause mortality, CHD and stroke death was examined using data on 34,192 white, non-Hispanic participants in the Adventist Health Study.

Among the 27,342 reporting no CHD, stroke or diabetes at baseline, during six years …