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Full-Text Articles in Medicine and Health Sciences

An Acknowledgement To The Hca Healthcare Journal Of Medicine's Reviewers And Editors For The 2nd Half Of 2024, Juan A. Sanchez, Graig Donini Feb 2025

An Acknowledgement To The Hca Healthcare Journal Of Medicine's Reviewers And Editors For The 2nd Half Of 2024, Juan A. Sanchez, Graig Donini

HCA Healthcare Journal of Medicine

The HCA Healthcare Journal of Medicine would like to thank those behind the scenes who make this publication possible. Our journal would not be possible without the assistance of our peer reviewers, authors, and board members.


A New Chapter For The Hca Healthcare Journal Of Medicine: Elevating Our Impact And Vision, Juan A. Sanchez Feb 2025

A New Chapter For The Hca Healthcare Journal Of Medicine: Elevating Our Impact And Vision, Juan A. Sanchez

HCA Healthcare Journal of Medicine

Dr Juan A Sanchez, the new editor-in-chief of the HCA Healthcare Journal of Medicine, shares his vision for elevating the journal's influence by publishing high-quality, impactful research. Moving forward, the journal will introduce new initiatives, including more special issues and invited editorial commentaries, to foster a dynamic academic environment. Dr Sanchez invites the medical community to contribute and engage with the journal to advance medical knowledge and improve health care outcomes.


Thai Sugar-Sweetened Beverage Tax: Does It Really Help?, Sitaporn Suriya, Buraskorn Torut Feb 2025

Thai Sugar-Sweetened Beverage Tax: Does It Really Help?, Sitaporn Suriya, Buraskorn Torut

Kesmas

A solution recommended by the World Health Organization to prevent and control noncommunicable diseases is the Sugar-Sweetened Beverage (SSB) tax. This study aimed to evaluate the Thai SSB tax efficiency affecting the change in post-tax individual-level consumption and find causal explanations for the people’s consumption behavior after the SSB tax was implemented. This study used a Productivity Model, and stratified random sampling was conducted by selecting 1,200 people. An in-depth interview was conducted to seek causal explanations for post-SSB tax consumption behavior with 15 key informants. The results revealed the SSB tax’s efficiency in terms of perception and understanding at …


Socio-Epidemiological Perspectives Of Sexual Trauma Experiences And Influential Factors On Sexual Orientation In Men Who Have Sex With Men, Rico Januar Sitorus, Misnaniarti Misnaniarti, Legiran Legiran, Rizma Adlia Syakurah, Diana Dewi Sartika, Asri Maharani, Retta Patresia Feb 2025

Socio-Epidemiological Perspectives Of Sexual Trauma Experiences And Influential Factors On Sexual Orientation In Men Who Have Sex With Men, Rico Januar Sitorus, Misnaniarti Misnaniarti, Legiran Legiran, Rizma Adlia Syakurah, Diana Dewi Sartika, Asri Maharani, Retta Patresia

Kesmas

The complexity of sexuality and sexual trauma experiences, including harassment, unwanted touching, sexual urges, and forced sexual intercourse, should not be underestimated because of the tendency to initiate adverse psychosocial impacts. Sexual harassment can increase mental health risks, which may influence sexual orientation decisions. This quantitative study, using a cross-sectional design, aimed to determine a relationship between sexual trauma experiences and sexual orientation in men who have sex with men (MSM). This study population was MSM living in Palembang and Prabumulih City, with a sample size of 216 respondents. The proportion of respondents with homosexual orientation was 57.1%, and the …


The Spread Of Tuberculosis Cases In The Highlands And Coastal Areas Of Padang, Rapitos Sidiq, Indang Dewata, Heldi Heldi, Nurhasan Syah, Linda Handayuni, Al Asyary Feb 2025

The Spread Of Tuberculosis Cases In The Highlands And Coastal Areas Of Padang, Rapitos Sidiq, Indang Dewata, Heldi Heldi, Nurhasan Syah, Linda Handayuni, Al Asyary

Kesmas

The current tuberculosis (TB) worldwide situation is very concerning in terms of the number of cases and the death toll, as well as the environmental factors that contribute to its transmission. This has driven policy decisions that aim to enhance contemporary TB control efforts. This study aimed to map the pattern of TB spread based on geographic location, particularly in the highland and coastal areas of Padang City, West Sumatra Province, Indonesia. This study employed a quantitative descriptive analysis using secondary data from 6 primary health care (PHC) from April 2022 to March 2023, comprising 896 cases. Data analysis was …


Characteristic And Survival Analysis Of Infants With Critical Congenital Heart Disease, Suprohaita Rusdi Talib, Johanes Edy Siswanto, Mulyadi M. Djer, Nurzalia Safanta, Syifa Nurhakiki, Khobir Abdul Karim Taufiqurahman, Asri Adisasmita Feb 2025

Characteristic And Survival Analysis Of Infants With Critical Congenital Heart Disease, Suprohaita Rusdi Talib, Johanes Edy Siswanto, Mulyadi M. Djer, Nurzalia Safanta, Syifa Nurhakiki, Khobir Abdul Karim Taufiqurahman, Asri Adisasmita

Kesmas

Congenital heart disease (CHD) is a major health concern worldwide. This study focused on survival analysis and the factors influencing survival in infants with critical congenital heart disease (CCHD). A total of 79 infants diagnosed with CCHD were identified, with 48.1% (n=38) exhibiting duct-dependent pulmonary circulation, 35.6% (n=28) exhibiting duct-dependent systemic circulation, 6.3% (n=5) exhibiting critical non-duct-dependent, and 10.2% (n=8) exhibiting parallel circulation issues. Of the infants studied, 55.7% (n=44) were male, 78.5% (n=62) had a gestational age of ≥37 weeks, 62% (n=49) had a birth weight of ≥2,500 grams, 59.5% (n=47) exhibited normal fetal growth, 93.7% (n=74) experienced no …


Adolescent Reproductive Health Promotion For Senior High School Students, Niken Meilani, Sunarru Samsi Hariadi, Fransiskus Trisakti Haryadi Feb 2025

Adolescent Reproductive Health Promotion For Senior High School Students, Niken Meilani, Sunarru Samsi Hariadi, Fransiskus Trisakti Haryadi

Kesmas

Adolescence is a vulnerable period to reproductive health problems, especially regarding issues of sexuality. Healthy adolescent behavior is needed to achieve the SDGs targets by 2030. This study aimed to analyze personal factors such as attitudes, perceptions, and self-efficacy, as well as environmental factors like family, school, friends, community, and social media's role in adolescent reproductive health behavior and health promotion models. This quantitative analysis was conducted using the survey method with 326 respondents at 32 senior high schools, involving 159 male and 167 female adolescents, as samples taken through a multistage random sampling technique. This study used a questionnaire …


Prevalence Of Low Back Pain Among Office Workers During The Covid-19 Pandemic In Various Countries: A Systematic Review, Yosephine Roma Intan, Ririn Arminsih Wulandari, Popy Yuniar Feb 2025

Prevalence Of Low Back Pain Among Office Workers During The Covid-19 Pandemic In Various Countries: A Systematic Review, Yosephine Roma Intan, Ririn Arminsih Wulandari, Popy Yuniar

Kesmas

The COVID-19 pandemic has led to the implementation of work from home policies in almost all parts of the world. This policy has increased the onset of musculoskeletal disorders in workers, such as low back pain (LBP). This study aimed to examine the prevalence of LBP among office workers during the COVID-19 pandemic after implementing WFH policies. This study was performed using data from various countries to determine the relationship between LBP and several risk factors, specifically age, sex, physical activity, ergonomic factors, as well as work environment factors such as temperature, humidity, lighting, noise, and work duration. A systematic …


Exploring Physician Well-Being: A Bibliometric Analysis Of Mental Health, Suriya Kumareswaran, Bala Murali Sundram, Vanitha Thurairasu Feb 2025

Exploring Physician Well-Being: A Bibliometric Analysis Of Mental Health, Suriya Kumareswaran, Bala Murali Sundram, Vanitha Thurairasu

Kesmas

This bibliometric study examined the evolving research landscape on physician mental health from 2010 to 2023, analyzing key themes, publication trends, and global contributions. A total of 3,360 articles, including 3,137 original research and 223 reviews, were sourced from Web of Science and Scopus. Findings revealed a significant increase in research output, particularly during the COVID-19 pandemic, with burnout, depression, and anxiety emerging as dominant themes. The US accounted for most publications, while research from low- and middle-income countries remains limited, indicating a substantial global disparity. Thematic analysis highlighted variations in burnout assessment methodologies, underscoring the need for standardized evaluation …


Determinants Of Adolescent Resilience Levels In Surabaya City, East Java Province, Indonesia, Riris Diana Rachmayanti, Fatwa Sari Tetra Dewi, Diana Setiyawati, M Dody Izhar, Andrei Ramani Feb 2025

Determinants Of Adolescent Resilience Levels In Surabaya City, East Java Province, Indonesia, Riris Diana Rachmayanti, Fatwa Sari Tetra Dewi, Diana Setiyawati, M Dody Izhar, Andrei Ramani

Kesmas

Assessing adolescent resilience may provide valuable insights into adult resilience. This study aimed to analyze the relationship between determinants and adolescent resilience in Surabaya City. The participants of this cross-sectional study were 277 adolescents aged 12–19 years who were in senior high school. The outcome was the resilience levels. This study's findings indicated relationships between resilience levels and stress experience (p-value = 0.01), access to mental health information (p-value = 0.00), life satisfaction (p-value = 0.00), family harmony (p-value = 0.03), presence of adults to share (p-value = 0.04), feeling safe at home, school, and community (p-value = 0.00), perception …


Five-Year Journey Of Technical Assistance In Health Governance Reforms: A Case Report, Popy Yuniar, Indang Trihandini, Ibnu Muyassar, Latifatul Khoiriyah, Minawati Minawati, Fathiyya Aliyah Birjaman, Tyra Septi Diana, Annabel Serafina, Hertina Raisa Putri, Rana Maimunah, Riko Setiawan, Nadazaira Alifia Ramadhianisa, Aris Diyanto Feb 2025

Five-Year Journey Of Technical Assistance In Health Governance Reforms: A Case Report, Popy Yuniar, Indang Trihandini, Ibnu Muyassar, Latifatul Khoiriyah, Minawati Minawati, Fathiyya Aliyah Birjaman, Tyra Septi Diana, Annabel Serafina, Hertina Raisa Putri, Rana Maimunah, Riko Setiawan, Nadazaira Alifia Ramadhianisa, Aris Diyanto

Kesmas

Many districts and cities in Indonesia continue to have Public Health Development Index scores below the national average, highlighting the need for improved health governance. This study assessed the five-year impact (2019–2023) of a mentoring program for 149 District Health Offices in preparing annual work plans, focusing on stagnation or performance declines. Using a qualitative approach, the study analyzed annual work plan scores before and after technical assistance, conducted focus group discussions, and carried out in-depth interviews to identify challenges. Key barriers included data management issues, weak advocacy, knowledge transfer gaps, and poor cross-sectoral coordination, which hindered decision-making and program …


Help-Seeking Behavior And Related Mental Health Promotion Programs In Southeast Asian Youth: A Systematic Literature Review, Gladys Octavia, James A. Doorbar, Kallista Chan Feb 2025

Help-Seeking Behavior And Related Mental Health Promotion Programs In Southeast Asian Youth: A Systematic Literature Review, Gladys Octavia, James A. Doorbar, Kallista Chan

Kesmas

Mental health issues are a prominent burden among adolescents and young adults in Southeast Asia, compounded by reluctance to seek help and low treatment rates. This mixed-method systematic review analyzed help-seeking profiles (preference, facilitators, and barriers) and evaluated implemented help-seeking programs. Data were sourced from electronic databases, hand-searched local databases, conference proceedings, and grey literature. Study selection followed PRISMA 2020 guidelines, focusing on 1) adolescents (10–19 years) and young adults (18–26 years) in Southeast Asia who were not receiving mental health care, 2) assessing help-seeking behavior, and 3) evaluating programs to increase help-seeking. A total of 16 articles were identified. …


Public Health Entrepreneurship In Indonesia: What Is Next?, Hadi Pratomo, Roy Darmawan, Karina Samaria Feb 2025

Public Health Entrepreneurship In Indonesia: What Is Next?, Hadi Pratomo, Roy Darmawan, Karina Samaria

Kesmas

Public health has been demanded to search for ways to improve well-being by tackling societal and ecological factors that influence health through cooperative strategies and partnerships across various fields. More interdisciplinary, interprofessional, and action-oriented approaches toward sustainable public health programs are recommended to be made. Therefore, public health entrepreneurship is an indispensable approach to creating new interventions that address future public health problems. The Indonesian Ministry of Health conceptualized five public health entrepreneurship skills as standard competence for public health personnel. In addition, the Association of Indonesian Public Health Higher Education Institutions has identified several study materials and learning outcomes …


The Correlation Between The Amount Of Weight Gain And Physical Activity Levels In Depot Medroxyprogesterone Acetate (Dmpa) Users, Zumroh Hasanah, Desiana Merawati, Raja Mohammed Firhad Raja Azidin, Dessy Amelia, Alifia Candra Puriastuti, Rizqie Putri Novembriani, Nurya Viandika, Putri Nurika Dewi Feb 2025

The Correlation Between The Amount Of Weight Gain And Physical Activity Levels In Depot Medroxyprogesterone Acetate (Dmpa) Users, Zumroh Hasanah, Desiana Merawati, Raja Mohammed Firhad Raja Azidin, Dessy Amelia, Alifia Candra Puriastuti, Rizqie Putri Novembriani, Nurya Viandika, Putri Nurika Dewi

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: DMPA is a widely used contraceptive in Indonesia due to its accessibility and effectiveness. However, side effects such as weight gain are a concern, with more than 90% of the 600 users in 2022-2023 experiencing them. Objective: This study aimed to examine the correlation between the amount of weight gain and physical activity levels in DMPA users. Methods: This study used a cross-sectional design with consecutive sampling, involving 82 women (aged 19-51 years, average weight 58 kg) selected using the Slovin formula. Data were collected through structured interviews and questionnaires covering demographics, medical history, and physical activity level based …


Development Of A Futsal Sports Curriculum Model Aged 6-8 Years At The Super Junior Club In Malang City, Dwi Novenda, Prisca Widiawati Feb 2025

Development Of A Futsal Sports Curriculum Model Aged 6-8 Years At The Super Junior Club In Malang City, Dwi Novenda, Prisca Widiawati

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The lack of a structured futsal curriculum for children aged 6-8 years in futsal clubs, especially in Super Junior Club Malang, causes limitations in developing techniques, skills, and long-term athlete development. Objective: This is for developing a futsal curriculum model at the Super Junior Club of Malang City, which is presented as a curriculum for learning. Methods: The research and development model used in the study is to develop a curriculum model. Development research This uses the ADDIE method with steps study as follows: 1) analysis, 2) design, 3) development, 4) implementation, and 5) evaluation. This is done using …


The Synergistic Effects Of Circuit Training And Diet On Weight Loss, Body Fat Percentage, And Bmi In Obese Indonesian Females: A Randomized Controlled Trial, Ali Muthahhari Rahim, Ahmad Nasrulloh Feb 2025

The Synergistic Effects Of Circuit Training And Diet On Weight Loss, Body Fat Percentage, And Bmi In Obese Indonesian Females: A Randomized Controlled Trial, Ali Muthahhari Rahim, Ahmad Nasrulloh

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Despite the popularity of circuit training and dietary interventions, their combined effects on obese Southeast Asian populations remain underexplored.  Objective: This study aims to examine the effects of circuit training (using free weights and body weight) and dietary interventions (low-calorie diet and intermittent fasting using the OCD method), as well as their interaction, on weight loss, body fat percentage, and body mass index in obese individuals. Methods: This type of research is an experiment using a 2 x 2 factorial design. This experimental study used four groups that received different treatments, namely the provision of circuit training with free …


Wearable Technology For Cardiovascular Performance: A Systematic Review Of Smartwatch Applications In Fitness Training, Moch. Yunus, Nanang Tri Wahyudi, Ronal Surya Aditya, Alifia Candra Puriastuti, Daifallah M. Alrazeeni, Gadis Meinar Sari, Farsya Hidayah Septiananda, Lintang Nirmalasari Gemalochaya Manggolono Feb 2025

Wearable Technology For Cardiovascular Performance: A Systematic Review Of Smartwatch Applications In Fitness Training, Moch. Yunus, Nanang Tri Wahyudi, Ronal Surya Aditya, Alifia Candra Puriastuti, Daifallah M. Alrazeeni, Gadis Meinar Sari, Farsya Hidayah Septiananda, Lintang Nirmalasari Gemalochaya Manggolono

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Wearable technologies such as smartwatches have revolutionized cardiovascular fitness training through real-time monitoring and personalized exercise interventions. However, the effectiveness of smartwatch apps in improving cardiovascular performance still needs to be systematically evaluated.  Objective: This study aims to assess the contribution of smartwatch apps in improving cardiovascular fitness training using a systematic review based on the PRISMA framework. Methods: The research questions were designed using the PICO (Population, Intervention, Comparison, Outcome) model. A literature search was conducted in PubMed, Scopus, Google Scholar, Web of Science, and Crossref, focusing on articles published in 2020-2025 that met the inclusion criteria. Result: …


The Effects Of Competitive Plyometric Training On Speed, Strength, And Defensive Skills Of Handball Players, Abbas Abdulhamza Kadhem Feb 2025

The Effects Of Competitive Plyometric Training On Speed, Strength, And Defensive Skills Of Handball Players, Abbas Abdulhamza Kadhem

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The importance of this research lies in preparing handball players with enhanced physical and skill capabilities through modern methods such as competitive plyometric training. The study was motivated by observed performance inconsistencies among Iraqi handball teams, particularly a decline in players' physical and technical execution toward the end of matches. This issue is attributed to the use of traditional training programs, which fail to develop the players’ physical fitness and technical performance adequately.  Objective: This study examines the effects of competitive plyometric training on handball players' speed, strength, and defensive skills. Methods: The research was driven by the observation …


Reducing Burnout Among Physiatry Trainees During The Pandemic: Instituting A Wellness Retreat, Edwin Amirianfar, Oliver Acosta, Eduard Tiozzo, Joslyn Gober, Monica Verduzco-Gutierrez Feb 2025

Reducing Burnout Among Physiatry Trainees During The Pandemic: Instituting A Wellness Retreat, Edwin Amirianfar, Oliver Acosta, Eduard Tiozzo, Joslyn Gober, Monica Verduzco-Gutierrez

Journal of Wellness

Introduction: Burnout has been described as “a state of mental and physical exhaustion related to work or caregiving activities.” Among resident physicians, burnout is a serious concern that can lead to medical errors and negative patient outcomes. To combat burnout among physiatry trainees during the COVID-19 pandemic, an innovative wellness retreat was created and implemented at the University of Miami’s Physical Medicine and Rehabilitation (PM&R) Residency Program in March 2021 and February 2022.

Methods: The retreat curriculum was designed by the PM&R Residency Wellness Committee and supported by departmental funding. The retreat(s) consisted of three strategies: education and discussion on …


Pornography, Problematic Use And Academic Outcomes In College Students: A Cross-Sectional Analysis, Promise Tewogbola, Victoria Bodunde, Deborah Odaudu Feb 2025

Pornography, Problematic Use And Academic Outcomes In College Students: A Cross-Sectional Analysis, Promise Tewogbola, Victoria Bodunde, Deborah Odaudu

Journal of Graduate Education Research

Background: The prevalence of pornography consumption among college students has raised concerns about its potential impact on academic performance. This study aims to examine the relationships between pornography use, academic outcomes, and problematic pornography use among university students.

Methods: A cross-sectional study was conducted with 739 students from a Midwestern U.S. state university. Participants completed an online survey assessing demographics, grade point average (GPA), pornography consumption frequency, Academic Success Inventory (ASI) scores, and Problematic Pornography Use (PPU) scale scores. Logistic and linear regression analyses were used to examine associations between variables.

Results: Pornography consumers had 41% lower odds of …


Distal Femur Fractures: The Use Of A Fibular Strut Allograft With Dual Locking Plates Allows For Early Weight Bearing, Brian Rui Kye Chee, Chenghan Wu, Abhjeet Ashok Salunke, Yongsheng Chen Feb 2025

Distal Femur Fractures: The Use Of A Fibular Strut Allograft With Dual Locking Plates Allows For Early Weight Bearing, Brian Rui Kye Chee, Chenghan Wu, Abhjeet Ashok Salunke, Yongsheng Chen

BioMedicine

Introduction: Distal femur fractures result in high morbidity and mortality - comparable to that of hip fractures. The commonly used surgical fixation techniques today, locked plating and intramedullary nailing, have shown high postoperative complication rates. Thus, many surgeons temporarily keep patients non-weight bearing in the early post-operative stage. Increased time to ambulation after surgery is known to increase systemic complications in patients. We aim to investigate if an augmented fixation technique involving the use of a fibular strut allograft with dual locking plates helps to allow early mobilization postoperatively without adverse outcomes.

Methods: Five geriatric patients (four female, one male) …


Acute Phantosmia As The First Manifestaton Of Brain Metastases In A Patient With Breast Cancer. Case Report, Georgios I. Papageorgiou, Nikolaos Skouteris Feb 2025

Acute Phantosmia As The First Manifestaton Of Brain Metastases In A Patient With Breast Cancer. Case Report, Georgios I. Papageorgiou, Nikolaos Skouteris

BioMedicine

Phantosmia belongs to the group of olfactory dysfunctions. It is more commonly described in psychiatric conditions and some cases of viral infections, but it has been also rarely described in cancer patients who develop primary or metastatic central nervous system tumors; the early identification of this symptom in this population is crucial, as it could lead to timely diagnosis and treatment through a multidisciplinary approach.

With the current report we present the case of a 60-year-old lady with metastatic breast cancer and without known preexisting brain metastases, who developed acute phantosmia without other neurological deficits; computed tomography of the brain …


Estimated Levels Of Glycated Albumin And C-Reactive Protein/Total Albumin Ratio Might Distinguish Prediabetics Among The Apparently Healthy People And Predict The Vulnerability For Development Of Steatohepatitis And Cardiac Risk., Rizk S. Sarhan, Raafat R Mohammed Feb 2025

Estimated Levels Of Glycated Albumin And C-Reactive Protein/Total Albumin Ratio Might Distinguish Prediabetics Among The Apparently Healthy People And Predict The Vulnerability For Development Of Steatohepatitis And Cardiac Risk., Rizk S. Sarhan, Raafat R Mohammed

BioMedicine

Background: Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-gram oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer

Aims: The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.

Methods: IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if /dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance …


Plasma Levels Of Mir-21b And Mir-146a Can Discriminate Rheumatoid Arthritis Diagnosis And Severity., Rizk S. Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal As Ahmed Feb 2025

Plasma Levels Of Mir-21b And Mir-146a Can Discriminate Rheumatoid Arthritis Diagnosis And Severity., Rizk S. Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal As Ahmed

BioMedicine

Objectives: This study tried to examine the ability of the estimated plasma gene-expression levels (PGEL) of microRNA (miR)-146a and miR-21b to distinguish patients with early rheumatoid arthritis (RA) out of arthritis patients who did not fulfill the diagnostic spectrum of either RA or osteoarthritis (OA); the diagnostic Gray-Zone (GZ).

Patients & Methods: Enrolled patients underwent full diagnostic workup and were categorized as highseropositive and fulfilled the diagnostic spectrum for RA (RA-group), seronegative and fulfilling the diagnostic spectrum of OA (OA-group) and low-seropositive or seronegative patients who did not fulfill diagnostic criteria of RA or OA (GZ-group). Blood samples were obtained …


In-Silico Study Of Rosmarinic Acid Roles In Inhibiting Breast Cancer Progression, Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani Feb 2025

In-Silico Study Of Rosmarinic Acid Roles In Inhibiting Breast Cancer Progression, Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani

BioMedicine

Background: Breast cancer is the highest cancer incidence in the world. Chemotherapy is currently one of the main breast cancer treatments besides surgery. It is capable of evolving to become resistant to chemotherapy agents. Chemotherapy also has significant side effects. Rosmarinic acid could become an anti-cancer agent candidate for the treatment of breast cancer, but its molecular mechanism is still unclear.

Aim: This study aimed to clarify the molecular mechanism of rosmarinic acid anti-breast cancer properties via an in-silico study.

Methods: Web-based screening tools such as SwissTargetPrediction, Similarity Ensemble Approach (SEA), and TargetNet were used as initial screening. From web-based …


Unveiling Role Of Oncogenic Signalling Pathways In Complicating Breast Cancer, Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Rashmi Mittal Feb 2025

Unveiling Role Of Oncogenic Signalling Pathways In Complicating Breast Cancer, Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Rashmi Mittal

BioMedicine

Heterogeneous nature of breast cancer has significantly affected the overall survival, disease free survival and progression free survival amongst the diseased individuals. Metastasis of cancerous cells to distant sites including bone, lungs, liver, lymph node and others have further exhilarated the adverse effects. However, ER, PR and HER-2 are responsible for normal physiological development of women but in altered conditions they may act as initiator or progressor and so far 5 subtypes of disease have been identified. Alteration of pro-survival, pro-proliferative and anti-apoptotic pathways including JAK/STAT, MAPK,

PI3K/AkT/mTOR, NF-κB, BCL2 and several others have induced oncogenic events including epithelial-mesenchymal transition, …


Mini-Review Of Clinical Data Service Platforms In The Era Of Artificial Intelligence: A Case Study Of The Ihi Data Platform, Yu-Ting Lin, Ya-Chi Lin, Hung-Lin Chen, Che-Chen Lin, Min-Yen Wu, Sheng-Hsuan Chen, Zi-Han Lin, Yi-Ching Chang, Chuan-Hu Sun, Sheng-Ya Lu, Min-Yu Chiang, Hui-Chao Tsai, Mei-Ju Shih, David Ray Chang, Fuu-Jen Tsai, Hsiu-Yin Chiang, Chin-Chi Kuo Feb 2025

Mini-Review Of Clinical Data Service Platforms In The Era Of Artificial Intelligence: A Case Study Of The Ihi Data Platform, Yu-Ting Lin, Ya-Chi Lin, Hung-Lin Chen, Che-Chen Lin, Min-Yen Wu, Sheng-Hsuan Chen, Zi-Han Lin, Yi-Ching Chang, Chuan-Hu Sun, Sheng-Ya Lu, Min-Yu Chiang, Hui-Chao Tsai, Mei-Ju Shih, David Ray Chang, Fuu-Jen Tsai, Hsiu-Yin Chiang, Chin-Chi Kuo

BioMedicine

In the past two decades, healthcare organizations have transitioned from the early stages of digitization and digitalization to a more comprehensive process of digital transformation, a shift significantly accelerated by the advent of artificial intelligence (AI). Consequently, the development of high-quality clinical data warehouses, derived from electronic health records (EHRs) and enriched with multidomain data, such as genomics, proteomics, and Internet of Things (IoT) information, has become essential for the creation of the modern patient digital twin (PDT). This approach is critical for leveraging AI in the evolving landscape of clinical practice. Leading medical centers and healthcare institutions have adopted …


Robotic Spine Surgery - Surgical Technique And Nuances For Improving Safety, Mun Chun Lai, Pirateb Paramasivam Meenakshi Sundaram, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh Feb 2025

Robotic Spine Surgery - Surgical Technique And Nuances For Improving Safety, Mun Chun Lai, Pirateb Paramasivam Meenakshi Sundaram, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh

BioMedicine

The integration of robotic technology into spinal surgery has led to a remarkable transformation, offering improved precision and safety. The “CT-Fluoro merge” and “Scan-and-Plan” methods for pedicle screw application promise numerous advantages, minimizing risks associated with traditional approaches. Our early series of patients who underwent robot-assisted pedicle screw placements for various indications, predominantly lumbar spondylosis, revealed no complications related to screws, neurological deficits, or unplanned returns to the operating theatre, thus emphasizing the safety and effectiveness of the robot. Studies have consistently demonstrated the superiority of robot-assisted pedicle screw placement in terms of accuracy, with decreasing rates of technical issues …


Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns Feb 2025

Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns

International Journal of Physical Activity and Health

This study aimed to examine how perceived parental mental and physical health status was associated with child physical activity, screen time, and sleep. Participants were 6- to 17-year-old minors (N = 20,156; 47.9% female) from the 2022 US National Survey of Children’s Health. Dependent variables were children’s physical activity frequency, screen time, and sleep. Independent variables were parents’ physical and mental health status. Using the Actor-Partner Interdependence Model, two adjusted path models were constructed. One for parent mental health associating with parental physical health, another for parent physical health associating with parental mental health–both further associating with child movement behaviors. …


Let’S Be Cool About It: Anticipating Proper, Whole-Human Cryopreservation And The Necessary Oversight For Adequate Consumer Protection, Peter Lyon Feb 2025

Let’S Be Cool About It: Anticipating Proper, Whole-Human Cryopreservation And The Necessary Oversight For Adequate Consumer Protection, Peter Lyon

Minnesota Journal of Law, Science & Technology

No abstract provided.