Medicine and Health Sciences Commons^™

Perceptions And Expectations Of Healthcare Professionals About The Roles Of Pharmacists At A Tertiary Care Hospital, Pimpiorn Punturat, Kornkaew Chanthapasa

The Thai Journal of Pharmaceutical Sciences

Background: Pharmacy education in Thailand has shifted toward a patient-centered approach through the implementation of the 6-year Doctor of Pharmacy (Pharm D.) program. Despite this transition, pharmaceutical care services remain limited due to challenges such as inadequate clinical skills, communication barriers, and differing perceptions among healthcare professionals. The perceptions and expectations of healthcare professionals about pharmaceutical care have not been fully examined in a tertiary hospital in Thailand. Objective: The objective of the study was to examine and compare the perceptions and expectations of pharmacists’ role in pharmaceutical care among physicians, nurses, and pharmacists at a tertiary care …

Pharmacovigilance Practices For New Drugs In Thailand: A Situation Analysis In Tertiary And University Hospitals, Nisittra Polkot, Osot Nerapusee, Pantira Parinyarux, Puree Anantachoti

The Thai Journal of Pharmaceutical Sciences

Background: In 2017, Thailand’s Food and Drug Administration introduced a risk-based safety monitoring program (SMP) aimed at strengthening pharmacovigilance (PV) for new drugs, including new chemical entities and biologics. Despite this policy shift, drug safety monitoring continues to rely primarily on spontaneous adverse drug reaction (ADR) reporting. This study aimed to explore the implementation of PV practices for drugs with SMP status in selected tertiary and university hospitals in Thailand.
Materials and Methods: A qualitative study was conducted using in-depth interviews. Pharmacists and physicians involved in drug safety monitoring were invited. Eight hospitals (five university and three tertiary …

Exploring Phytoconstituents For Parkinson’S Disease: Insights From Network Pharmacology, Molecular Modeling And In Vivo Investigations, Shiva Priya, Divakar Selvaraj, Rashi Jain, Kavyashree G. S., Soumya V., Venkatesh Gunasekaran, Ramu G., Saravanan Jayaram

The Thai Journal of Pharmaceutical Sciences

Background: The network pharmacology approach is used to identify novel therapeutic agents that target multiple disease targets through analysis of complex disease networks by integrating systems biology and computational approaches. Objectives: The present study aims to identify the principal targets implicated in the pathogenesis of Parkinson’s disease (PD) and major phytoconstituents that could potentially modulate the major targets to achieve therapeutic benefits in PD through a network pharmacology-based approach. Materials and Methods: The DisGeNET database was used to select the major targets involved in the pathogenesis of PD. The most important targets among the selected proteins were …

Isolation And Antibacterial Evaluation Of Bioactive Compounds From Mussaenda Philippica A.Rich.: A Bioassay-Guided Approach, M. Rifqi Efendi, Mesa Sukmadani Rusdi, Muhammad Iqbal, Ilham Padavi, Sri Indah Pirmawati, Deddi Prima Putra

The Thai Journal of Pharmaceutical Sciences

Background: Mussaenda philippica A.Rich. (commonly known as Nusa Indah in Indonesia), a member of the Rubiaceae family, has been traditionally used throughout Southern Asia to treat various ailments, including bacterial infections, inflammation, ulcers, and liver disorders. These medicinal uses are particularly associated with its bark, leaves, sepals, and root. Objectives: This study aimed to isolate and identify bioactive compounds from M. philippica white modified sepals using a bioassay-guided approach and evaluate their antibacterial activity.
Materials and Methods: The study consisted of four main stages: (i) methanol extraction and liquid–liquid partitioning of M. philippica sepals; …

Optimizing Solvent Composition For Enhanced Extraction Of Phenolic Content And Antioxidant Activity From Coleus Scutellarioides Through I-Optimal Mixture Design, Sinta Mutiara Dwi Lestari, Utami Dyah Syafitri, Waras Nurcholis

The Thai Journal of Pharmaceutical Sciences

Background: Reactive oxygen species are unstable molecules that contribute to oxidative stress and are associated with numerous degenerative diseases. The leaves of Coleus scutellarioides are rich in phenolic and flavonoid compounds, which possess strong antioxidant properties.
Objectives: This study aimed to optimize the composition of water, ethanol, and methanol as solvents using the I-optimal mixture design to enhance the extraction of total phenolic content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferric reducing antioxidant power (FRAP).
Methods: Each extraction was performed by macerating 1 g of powdered C. scutellarioides leaves in 20 mL of the designated …

Hot-Melt Extrusion-Based Solid Dispersion Of Aripiprazole: Preparation, Characterization, And In Vitro Evaluation, Nensi Raytthatha, Jigar Ramanlal Vyas

The Thai Journal of Pharmaceutical Sciences

Background: Aripiprazole (ARI), a biopharmaceutics classification system (BCS) class IV drug, exhibits poor water solubility and low permeability, resulting in limited bioavailability. Addressing these challenges requires innovative approaches to enhance solubility. This study focuses on the development and evaluation of solid dispersions (SDs) of ARI using “hot-melt extrusion,” (HME) a scalable and solvent-free method known for its ability to create stable amorphous structures. Soluplus^® (SP) and Kollidon® 30 were employed as hydrophilic polymeric carriers to improve the solubility and stability of the amorphous drug form. Results: SDs were prepared by taking drugs and carriers (SP and Kollidon …

Saudi Heart Association Position Statement On Nt-Probnp For Cardiovascular Risk Screening In Asymptomatic Adults With Type 2 Diabetes Mellitus, Waleed Alhabeeb, Adel , Tash, Abdullah Mohammed Abdullah Arabe, Lamya Alzubaidi, Ayman Al Hayek, Mohammed Ridha Al Safi, Malak Atallah Almashali

Journal of the Saudi Heart Association

Background: Type 2 diabetes mellitus (DM) is a chronic disease with a rapidly increasing prevalence, posing a significant public health challenge worldwide and in Saudi Arabia. Cardiovascular disease (CVD) is the leading cause of death among patients with T2DM, necessitating early detection and intervention to prevent disease progression. Elevated natriuretic peptide levels, particularly N-terminal pro–B-type natriuretic peptide (NT-proBNP), are promising biomarkers for CVD risk stratification in individuals with T2DM. However, the integration of these biomarkers in clinical management remains limited.

Methods: Published evidence and existing guidelines/consensuses related to the use of NT-proBNP for CVD risk stratification in T2DM patients were …

Insights Into The Role Of Microbial Infection In Recurrent Aphthous Stomatitis, Alaa W. Izzat, Batool Hassan Al-Ghurabi, Lina Sami Adham

Al-Esraa University College Journal for Medical Sciences

Ulcers that form in the oral mucosa are a hallmark of recurrent aphthous stomatitis (RAS), a chronic inflammatory disease. Up to 25% of the population may get aphthous ulcers, and recurrence rates within three months can reach 50%. Among women, it is more prevalent. Although the precise cause of RAS is not yet known, studies have shown that infections caused by microbes may be a major factor in the development of the disease. Infections caused by microorganisms have a complicated and multifaceted function in RAS, influencing the human immune system, the oral microbiota, and environmental variables. The purpose of this …

Anemia And Its Public Health Implications In Population Health, Sahar Abdul Wahab Alshaban, Raghda Shams Akram, Alaa Al-Noori, Noor Thair Tahir

Al-Esraa University College Journal for Medical Sciences

One to three percent of people worldwide suffer from anemia, a condition that impairs brain development, increases illness and mortality, and lowers labor productivity. Developing successful interventions to address specific causes of anemia and evaluating anemia management programs require an understanding of the numerous and diverse causes of anemia. The description and categorization of anemia, the physiological processes by which anemia arises, the importance of inherited hemoglobin abnormalities in specific populations, and a number of circumstances that contribute to the development of anemia are all covered. The conclusion of this review is as follows. Anemia is a significant global health …

Flowable Resin-Based Composites: From Fundamental Science To Modern Restorative Techniques, Farah Badri Mahdi, Hiba Ammar Yahya, Kawther Ali Adnan

Al-Esraa University College Journal for Medical Sciences

The function regarding flowable resin-based composites in restorative dentistry has considerably changed as they have been first introduced as low-viscosity alternatives in late 1990s. Because of the degraded mechanical properties and lower filler content, they were first just suitable for low-stress applications, like cavity liners. However, further advancements in the material science have produced highly-filled, next-generation flowables. The traditional trade-off between durability and fluidity is being challenged by materials’ improved properties, which include higher flexural strength and wear resistance. Furthermore, the development regarding bulk-fill flowables, which use advanced photoinitiators as well as polymerization modulators for the purpose of enabling uniform …

The Efficacy Of Traditional Versus Herbal Extracts Chelating Agents On Dentin Micro-Hardness, Sara Murtadha Abdul Hussein, Raghad A. Al-Hashimi

Al-Esraa University College Journal for Medical Sciences

Aim: To evaluate and compare the effectiveness of different chelating agents including EDTA, citric acid, green tea extract (Camellia sinensis, and chitosan on dentin micro-hardness.Materials and Methods: Fifty palatal roots of maxillary first molars were instrumented using ProTaper Next system and randomly divided into five groups (n = 10) according to the final irrigation protocol: Group A (NaOCl +distilled water - Negative control), Group B (17% EDTA-Positive control), Group C (10% citric acid), Group D (green tea extract), and Group E (0.2% chitosan nanoparticles). Dentin micro-hardness was measured using Vickers hardness tester. Data were analyzed using one-way ANOVA and …

Sport And Athletes Under The Shadow Of Covid-19 Pandemic, Abdul Razzaq Jabr Al Majidi, Rebah N. Algafari, Rehab S. Ramadhan, Rafia S. Fathi

Al-Esraa University College Journal for Medical Sciences

The end of 2019 witnessed the announcement of worldwide pandemic Covid-19 around the world that influenced every part of human life. Sports and athletes were one of these parts affected by the pandemic since many competitions and tournaments were canceled or postponed and put athletes under spotlight as an important category susceptible to infection or as they been admired and loved by the population may help in spreading infection. Following reports dealing with athletes, exercise, immunity, and severity of infection, the following points were concluded: first, moderate practicing boosts immune system and make the human less affected by Covid-19 infection …

Gamma-Ray Knife And Application Features In Medicine, Yaqoob. M. Baqer, Ayad A. Al-Taweel

Al-Esraa University College Journal for Medical Sciences

Gamma Knife radiosurgery (GKR) is a sophisticated procedure that delivers a concentrated dose of ionizing radiation to a pre-identified therapeutic target. A non-invasive radiation therapy intended to address numerous disorders impacting the brain and upper spine. The inaugural GKR facility was established by Leksell in 1951, during an era when intracranial surgical interventions resulted in significant morbidity and mortality. Initially intended for the management of functional problems, it was first employed to treat a patient with a craniopharyngioma and another with a pituitary adenoma. Initially, gamma radiation from radioactive cobalt sources was used instead of proton beams and linear accelerators. …

Comprehensive Review Of Facial Asymmetry: Etiology, Diagnosis, And Management Strategies, Hiba Ammar Yahya, Sara M. Al-Mashhadany

Al-Esraa University College Journal for Medical Sciences

A certain degree of facial asymmetry is not only a normal biological variation but can also contribute positively to perceived beauty. However, delineating the precise boundary between ‘normal’ asymmetry and ‘abnormal’ asymmetry, the latter necessitating clinical intervention, remains a complex and subjective endeavor. Minor facial asymmetry is commonly observed even in individuals with aesthetically attractive faces, typically remaining indiscernible and thus not requiring any treatment. The determination of when ‘normal’ asymmetry transitions into ‘abnormal’ is frequently influenced by clinician’s aesthetic judgment and, critically, the patient’s perception of imbalance. The perceived abnormality of facial asymmetry is, therefore, highly dependent on individual …

Genetic Basis Of Diabetic Retinopathy: Uncovering Molecular Links And Risk Factors—A Review Article, Ammar Kadhim Alzubaidi

Al-Esraa University College Journal for Medical Sciences

Genetics play a major role in diabetic retinopathy DR, which is a leading cause of blindness worldwide. Although the factors such as how long a person has had diabetes and high blood sugar are important, the wide variation and progression of DR indicates to a clear genetic influence. Early studies focusing on a few candidate genes (such as VEGF) produced conflicting and population-dependent results. This confirmed the multifactorial nature of the disease and the limitations of small-scale studies. Conversely, genome wide association studies (GWAS) have provided more consistent findings in detection a new genes related to DR. For example, rs2239785 …

Relationship Between Hashimoto Thyroiditis And Some Immunogenic Markers, Amani Mahmood Tuama, Aliyaa Taresh Obaid

Al-Esraa University College Journal for Medical Sciences

Hashimoto thyroiditis (HT) is a common autoimmune disorder, affecting women 7–10 times more often than men, that develops because of genetic susceptibility, X chromosome inactivation patterns modulated by environmental factors as well as micro biome composition, and leads to an imbalance in self-tolerance mechanisms. The consequential thyroid infiltration by lymphocytes, potentiated by antibody-mediated autoimmune response through the antibodies against thyroid peroxidase (TPO Abs), leads to a destruction of thyrocytes. The presence of TPO Abs is associated with a 2 to 4-fold increase in the risk of recurrent miscarriages and preterm birth in pregnant women. Aim: The aim of the study …

Wettability Assessment Of Room-Temperature Soft Liners Incorporated With Strontium Titanate Nanoparticles, Zakaria Azzam Alabed, Aseel Mohammed Al-Khafaji

Al-Esraa University College Journal for Medical Sciences

Background: Soft denture liners are widely used in prosthodontics for their ability to cushion masticatory forces and enhance comfort in patients with compromised oral mucosa. However, conventional liners often exhibit limitations such as poor adhesion to the denture base, microbial colonization, and inadequate mechanical stability. Materials and Methods: Strontium titanate (SrTiO₃) nanoparticles were incorporated into a self-cured soft denture liner. Three equal groups of fifteen specimens were created, each of which contained 0%, 1%, and 1.5% SrTiO₃ by weight. All procedures were conducted under simulated intraoral temperature, following manufacturer guidelines. Results: The analysis revealed statistically significant differences …

Gpbb And Tg/Hdl Ratio As Emerging Indicators In Iraqi Patients Diagnosed With Acute Coronary Syndrome, Alzahraa Ahmed Ammash, Walaa Ismael Jassim, Mohammed Mezher Hussien

Al-Esraa University College Journal for Medical Sciences

Background: ACS is one of the most critical health challenge worldwide. It consists of several conditions resulting from a sudden reduction in blood flow to the heart muscle. The early diagnosis is essential to improve the diagnostic accuracy and risk stratification. This relies on finding early, sensitive and specific biomarkers. Among these biomarkers are GPBB (glycogen phosphorylase isoenzyme BB), also referred to as the brain-type isoform (PYGB), which is primarily expressed in the brain and heart tissues and the triglyceride-to-HDL cholesterol ratio (TG/HDL). GPBB has recently gained interest as a potential early marker for myocardial ischemia with high novelty, whereas …

The Effect Of VItex Agnus-Castus L. Medium On In Vitro Oocyte Maturation Rate, Nabaa Al-Nawab

Al-Esraa University College Journal for Medical Sciences

In vitro maturation (IVM) of oocytes offers a possible alternative to traditional in vitro fertilization (IVF) for individuals susceptible to ovarian hyperstimulation syndrome (OHSS). The use of plant-derived bioactive composites as supplements in culture media has attracted attention for their potential to enhance oocyte developmental competence in the absence of synthetic hormones. This investigation aims to examine the effect of Vitex agnus-castus L. (VAC) aqueous extract on the in vitro maturation rate of murine oocytes. A total of 16 mature female mice were divided into two groups, 8 animals in each group. Immature oocytes were collected and cultivated for …

Detection Of Uropathogenic Bacteria In The Samples Of Iraqi Male Patients, Marwa M. Al-Attar

Al-Esraa University College Journal for Medical Sciences

Prostate disease is found in elderly persons, the prostate is a male reproduction organ. It is approximately the size of a plum that may be found near the bladder’s base. It is the primary cause of the three commonest diseases: prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PC). This study designed to identify the uropathogenic bacteria that caused prostate disorders in Iraqi male samples. A current study included 180 subjects from the Iraqi population, 135 patients were divided into three groups (prostate cancer, benign prostate hyperplasia and prostatitis), according to signs, symptoms and diagnosis by the physician each group …

Prevalence Of Aminoglycoside Resistance Genes Among Esβl Producer P. Aeruginosa In Burn Cases, Yasser Rabee Ibraheem, Majida Malik Alshammari

Al-Esraa University College Journal for Medical Sciences

Pseudomonas aeruginosa recurrently develops resistant towards aminoglycosides by gaining of aminoglycoside modifying enzyme (AME) genes. The study aimed to assess the antibiotic susceptibility profile of P. aeruginosa isolated from burn infections in hospitals in Baquba, AL Najaf and Karbala. Detection of genes that mediate the production of AMEs. 175 Burn swab (110 males and 65 females) were collected then cultured on MacConkey‘s and Blood agar for primary culture, and Cetrimide agar was used to isolate and purify the bacteria and incubated aerobically at 37°C for 24 hours. Then, Vitek 2 system to validate the results. Results revealed that 70 (40%) …

Antimicrobial Resistance Trends And Sccmec Typing Among Mrsa-Infected Diabetic Foot Cases In The Al-Najaf Community, Zahraa Hashim Abd Zaid Al-Sharoofi, Majida Malik Alshammari, Mohammed Abdzaid Akool

Al-Esraa University College Journal for Medical Sciences

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections worldwide, often linked to multidrug resistance and limited treatment options. This cross-sectional study aimed to investigate the molecular characteristics and antimicrobial resistance profiles of MRSA isolates recovered from diabetic foot ulcers in Al-Najaf Governorate, Iraq. A total of 76 S. aureus isolates were collected from patients attending three major hospitals. Identification was conducted using conventional microbiological methods, and methicillin resistance was confirmed phenotypically via cefoxitin disc diffusion and genotypically through PCR amplification of the mecA gene. SCCmec typing was performed using multiplex PCR. The findings revealed that 92.1% of …

Structure-Based Repurposing Of Clinically Approved Compounds For Pde-5 Inhibition: Integrative Computational And Pharmacokinetic Evaluation, Albashir Tahir, Yasir Idris Saleh, Ibrahim Khaleel Muazu

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Phosphodiesterase-5 (PDE-5) regulates intracellular cyclic guanosine monophosphate (cGMP) levels, modulating vascular smooth muscle tone. Sildenafil, a well-established PDE-5 inhibitor, is effective for erectile dysfunction and pulmonary hypertension but causes dose-dependent adverse effects. Identifying alternative scaffolds with comparable efficacy and improved safety remains a pharmacological priority.

Methods: A ligand-based virtual screening of the DrugBank database was performed using sildenafil as a reference. Compounds exhibiting ≥60% structural and electrostatic similarity were docked into the PDE-5 catalytic domain (PDB ID: 2h42) using Glide XP in the Schrödinger Suite. Top-scoring ligands were assessed for physicochemical, pharmacokinetic (ADMET), and toxicity parameters using SwissADME and …

Design And Mechanistic Investigation Of Novel Metallodrugs: From Structure-Activity Relationships To Selective Cancer Cell Targeting, Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance of our recent advances in designing novel metallodrugs based on pyridine-2,6-dicarboxylate derivatives coordinated with various metal ions (Ga(III), Ce(IV), Zn(II), Cu(II), Ni(II), Sr(II)). Through systematic synthesis and evaluation, we establish how strategic structural modifications dictate cytotoxicity, cellular uptake, and mechanistic pathways. Our comprehensive in vitro profiling across a panel of human cancer cell lines (including A431, SW480, BEL-7404) revealed potent anticancer activity, with IC50 values as low as …

Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Sphenocentrum jollyanum Pierre (Menispermaceae) is a West African medicinal plant used traditionally for various ailments, including malaria, diabetes, and reproductive disorders. Despite its ethnobotanical significance, comprehensive scientific validation of its pharmacological properties remains limited. This review aims to provide a comprehensive overview of the plant’s ethnobotany, phytochemistry, and pharmacological activities, integrating traditional knowledge with modern scientific insights to guide future research. A comprehensive literature search was conducted in PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Science, covering publications up to April 2025. Search terms included "Sphenocentrum jollyanum", "ethnobotanical use", "pharmacological effects", and related keywords. Relevant articles were screened, and …

Green Pharmaceutical Systems: Alpha-Tocopherol Encapsulation In Nanostructured Lipid Carriers Via Microwaves-Based Technique As Advanced Topical Drug Delivery Systems, Hayder Kadhim Drais, Mohammed A Albarki, Hayder Ridha-Salman, Ahmed Abbas Hussein, Ashraf Abbas Drais

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Alpha tocopherol (Vitamin E) is practically insoluble in water. It is important for skin health due to its many therapeutic actions, such as antioxidant, anti-inflammatory, and photoprotection. Therefore, the purpose of this study is to develop, prepare, and evaluate nanostructured lipid carriers (NLCs)-based hydrogels as a topical dosage form to improve stability and therapeutic activity of vitamin E. The microwave-based method prepared five lavender oil-based NLCs (LN1–LN5) formulations that were assessed thermodynamically and entered into characterization processes. Hydrogels formulations based on NLCs (LNG1–LNG5) were prepared and evaluated. All of the lavender oil-based NLC formulations (LN1–LN5) had suitable surface charge, a …

History And Prevention Of Foot-And-Mouth Disease Virus In Iraq: A Review, Ashwaq M. S. Al-Jbouri, Baraa Hamid Hadi, Saad Mardi Muhammad, Raoof J. A. Maaroof, Nada Khazal K. Hindi, Karrar Kamoona, Zainab Ayad, Rusul Ahmed Mohammed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Foot-and-mouth disease Virus (FMDV) is an extremely transmittable viral illness that affects cloven-hoofed faunae, such as cattle, goats, sheep, and pigs. This study aimed to demonstrate the history and prevention of foot-and-mouth disease (FMD) in Iraq. This virus poses a significant threat to the economy, necessitating strict measures to control and prevent its spread, particularly due to its high morbidity and mortality rates, especially in young faunae. It is one of the most contagious diseases as it is transmitted directly or indirectly from a diseased fauna to a healthy one through contact with resources contaminated with the virus, such as …

P-E-S-T-O-G-O: This Third Circuit Ruling Has Got To Go, A Deep Dive Into The Circuit Split Issue Of Fifra Preemption, R. Dylan Smith

Journal of Food Law & Policy

The American public is becoming increasingly concerned about pesticides. From “forever chemicals” to environmental justice concerns, public awareness of pesticide issues is only becoming more prevalent. However, one pesticide has seized public attention in a significant way. Glyphosate, the active ingredient in Monsanto’s “Roundup” and other commercial pesticides has been the subject of heated debate in federal courtrooms across the nation. The rising controversy over glyphosate has even led some jurisdictions to attempt to ban or restrict the use of the product altogether.

While the scientific studies and legal definitions about glyphosate and its cancer link are inconsistent, a reasonable …

Pattern Of Ultra Processed Food (Upf) Consumption And Mental Wellbeing Of Medical Undergraduates Of Chengalpattu District, Tamil Nadu, India – A Cross Sectional Study, Nithin C, Sumedha K, Murugan V

Digital Journal of Clinical Medicine

Abstract:

Background: Nutrition plays a crucial role in the health and development of individuals. In recent years, the rise in ultra-processed food (UPF) consumption, especially among young adults, has been linked to various health issues, including mental health concerns. This study aims to assess the pattern of UPF consumption and its impact on the mental well-being of medical undergraduates in Chengalpattu district, Tamil Nadu.

Methods: A cross-sectional study was conducted among 384 medical undergraduates aged 18 years and above enrolled in three tertiary care teaching hospitals. Data was collected using a questionnaire, which included demographic details, lifestyle factors, a UPF …

Therapeutic Role Of Hydroxyurea In Paediatric Hydroxyurea Pertussis: A Systematic Review, Abdullah H. Alhamoud, Mohammed Y. Suhaqi, Qasem A. Arishi, Fahd Y. Somili, Hassan M. Gohal, Abdulaziz S. Almalki, Mohammed A. Eidoh, Fadhel Y. Hazazi

Sultan Qaboos University Medical Journal

This systematic review indicates that hydroxyurea may be a promising pharmacologic option for leukoreduction in paediatric critical pertussis. In reported cases, hydroxyurea was associated with leukocyte reduction and short-term survival. Its ability to potentially reduce the need for invasive leukoreductive procedures is especially relevant in resource-limited settings. While these observations are encouraging, the evidence base remains limited to a small number of uncontrolled case reports and case series, with inconsistent safety monitoring and no long-term follow-up. Given the very low certainty of the available evidence, these results should be considered preliminary and hypothesis-generating. Further well-designed, multicentre studies and randomised trials …