Safety And Efficacy Of Adalimumab Biosimilar In Psoriasis And Hidradenitis Suppurativa: A Clinical Experience, Raneem H. Najjar, Sarah O. Alrashid, Rnda F. Almahfouz, Hadeel T. Alzahrani, Majed Y. Aleissa, Alanoud R. Hakami

Saudi Medical Journal

Objectives: To evaluate the clinical experience, safety, and effectiveness of adalimumab biosimilars in patients with psoriasis and hidradenitis suppurativa.

Methods: We conducted a retrospective, single-center observational study between March and September 2024 using electronic medical records from King Abdulaziz Medical City and King Abdullah Specialized Children's Hospital, Riyadh, Saudi Arabia. Pediatric and adult patients with psoriasis or hidradenitis suppurativa who switched to adalimumab biosimilars between 2016 and 2022 were included. Variables included demographics, disease characteristics, prior therapies, biosimilar use, and adverse events.

Results: A total of 57 (93% adults; 50.9% female) patients were included. Obesity was present in 35.1%, and …

Immunoinformatic Based Development Of A Multi-Epitope Precision Vaccine Targeting Glycoprotein And Rdrp Of Oropouche Virus: An Innovative Approach To Counter Emerging Public Health Threats, Mohammed Alissa, Muhammad Suleman

Saudi Medical Journal

Objectives: To design high immunogenic vaccine against the Oropouche virus (OROV). The OROV is a neglected arbovirus endemic to Central and South America, causes oropouche fever, which can progress to severe complications such as meningitis and hemorrhagic symptoms.

Methods: We utilized immunoinformatic and molecular dynamic simulation approaches to design highly immunogenic vaccines against OROV. This observational study, carried out between January and August 2024 in Saudi Arabia. As it involves an in-silico method, ethical consent was not required.

Results: Docking analysis confirmed the stable interaction of the designed vaccines with human toll-like receptors (TLR)-3, producing binding scores of –300.78, –306.19, …

Comparison Of The Effects Of Incubator And Radiant Environments On Physiological Criteria And Pain-Stress Levels During Heel Lance In Neonates In The Neonatal Intensive Care Unit: A Randomized Controlled Trial, Sezin Gürsu, Birsen Karaca Saydam, Oğuzhan Kalkanl\I

Saudi Medical Journal

Objectives: To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU).

Methods: This randomized controlled quasi-experimental study was conducted between June and December 2023 with newborns diagnosed with IHB hospitalized at a NICU in Turkey. Prior to the heel prick procedure, 72 newborns (gestational age: 37–41 weeks) were randomly and equally assigned to either a radiant heater or an incubator setting. Physiological parameters (temperature, SpO₂, heart rate [HR]) and pain-stress scores of the newborns were measured and compared in both …

Etiology, Management, And Outcomes Of Hospitalized Heart Failure Patients: A Single-Center Study, Adil I. Jumani, Ghada A. Rashwan, Hadiza O. Ibrahim, Safaa M. Almohdar, Khaled M. Alfakih

Saudi Medical Journal

Objectives: To describe the clinical characteristics, etiologies, management patterns, and outcomes of hospitalized heart failure patients in a tertiary care military hospital in United Arab Emirates (UAE), and to benchmark guideline directed medical therapy (GDMT) uptake and care models against regional and international registries.

Methods: We retrospectively reviewed all consecutive patients admitted with a primary diagnosis of heart failure between January and December 2024, at Zayed Military Hospital, UAE. Clinical data were extracted from electronic medical records. The GDMT adherence was assessed according to the 2022 American Heart Association (AHA)/ American College of Cardiology (ACC) and 2023 European Society of …

Identification Of Risk Factors For Renal Insufficiency In Primary Membranous Nephropathy, Lin Qi, Bolong Fang, Xiao Fang, Yamin Yu, Yunqiang Wang

Saudi Medical Journal

Objectives: To identify possible evidence linking certain characteristics associated with primary membranous nephropathy (PMN) to renal failure progression in patients diagnosed with PMN and to establish probable evidence of an association between PMN and other risk factors leading to end-stage renal failure.

Methods: A historical investigation was carried out including 436 subjects with PMN, with or without renal insufficiency, who were treated at the No. 82 Division Defense Medical Center of the People's Liberation Army and Liaocheng People's Medical Center during January 2020 and December 2023. Binary logistic regression study was applied to determine possible hazard elements. Binary logistic regression …

Evaluation Of Raqeem Health Information System In Primary Healthcare Centers In Makkah, Saudi Arabia, Using The Delone And Mclean Information System Success Model, Ali M. Alzahrani, Holly C. Felix

Saudi Medical Journal

Objectives: To evaluate the implementation of Raqeem, a new Electronic Health Information Systems (EHIS) implemented at primary healthcare centers (PHCs) in Makkah. Implementing EHIS requires huge investments, making evaluation of systems success important.

Methods: In this cross-sectional survey design study, a developed questionnaire guided by DeLone and McLean Information System success model (D&M model) was used to collect data from PHCs' providers. Descriptive and structural equation modeling (SEM) techniques were performed to describe and examine the association between the model's constructs and assess Raqeem success.

Results: A total of 490 providers submitted completed records and were included in this study. …

Molecular Mechanisms Of Diffuse Large B-Cell Lymphoma And The Complexities Of Tumor Development, Wael I. Alzahrani

Saudi Medical Journal

Diffuse large B-cell lymphoma (DLBCL), the most prevalent aggressive non-Hodgkin lymphoma, exhibits substantial molecular heterogeneity and arises from germinal center or post-germinal center B cells through recurrent genetic and epigenetic dysregulation of critical signaling pathways. Aberrations involving BCL6, MYC, MYD88, and components of B cell receptor and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B) signaling play central roles in lymphomagenesis, treatment resistance, and clinical outcomes. Gene expression profiling has defined major molecular subgroups in DLBCL, including germinal center B cell–like and activated B cell–like tumors, that show distinct pathogenesis and prognosis. High-risk entities, such as double- and …

Integrating Traditional And Complementary Medicine Into Saudi Primary Care: A Literature Review In Light Of The Who 2025–2034 Strategy, Abeer Al Shahrani

Saudi Medical Journal

Complementary and alternative medicine (CAM) is widely practiced in Saudi Arabia, particularly for health promotion and chronic diseases management. Despite cultural acceptance and high utilization, CAM remains largely unintegrated within the formal healthcare system, particularly in primary care settings. The newly adopted World Health Organization (WHO) Traditional, complementary, and integrative medicine (TCIM) Strategy 2025–2034 offers a global framework for evidence-based, culturally appropriate integration of TCIM into national systems. This review evaluates the status of CAM in Saudi Arabia in light of strategic objectives outlined in the WHO Strategy: building the evidence base, ensuring quality and safety, integrating into health systems, …

Interleukin-6 Inhibition For Patients With Acute Myocardial Infarction: A Systematic Review And Meta-Analysis, Mohammed Y. Alasmary, Mohammed J. Almalki, Faisal H. Almalki, Waleed D. Khubzan, Mohammed H. Rajab, Mohammed S. Almalki, Hussam A. Almalki, Omar M. Alsuwat, Hussam M. Alghannami

Saudi Medical Journal

Objective: To explore the outcomes associated with interleukin-6 (IL-6) pathway blockade, using tocilizumab, in patients with ST-elevation myocardial infarction (STEMI) and non (NSTEMI). Acute myocardial infarction (AMI) denotes myocardial necrosis due to ischemia and presents in distinct electrocardiographic phenotypes. Inflammation driven by IL-6 contributes to ischemia-reperfusion injury, with tocilizumab showing promise in reducing myocardial damage and improving outcomes.

Methods: This work followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Framework and was registered in international prospective register of systematic reviews (PROSPERO). Relevant studies were identified through structured searches of PubMed, MEDLINE, the Cochrane Library, and Google Scholar up …

Effect Of Anesthetic Agents On Middle Ear Pressure: Systematic Review And Meta-Analysis, Nasser Almujaiwel, Reem Alkublan, Latifah Almakoshi

Saudi Medical Journal

Objective: To assess and compare the effects of these agents on middle ear pressure (MEP). Anesthetic agents can significantly alter MEP, which is a critical factor in middle ear surgeries that require stability to prevent complications. Different anesthetics, including inhalational and intravenous agents, have varying effects on MEP.

Methods: A systematic search was conducted across PubMed, Embase, the Cochrane Library, and Scopus, following preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Studies that evaluated MEP changes before and after anesthesia using tympanometry were included. Relevant data, such as anesthetic type, patient demographics, MEP measurements, and reported complications, were …

The Impact Of Exercise Intervention On Pulmonary And Physical Function In Patients With Cystic Fibrosis: A Comprehensive Systematic Review, Abdullilah Alghamdi, Muroj Al-Attas, Abrar Radhi, Amnah Alfaqih, Bashair Aljabri, Rawan Alharbi, Sumayyah Alsubaie, Raneem Aljawaied, Sarah Alenazi, Ahlam Mazi, Ebtehal Qulisy

Saudi Medical Journal

Objective: To evaluate the effect of various exercise interventions on lung function, specifically forced expiratory volume in 1 second (FEV₁), maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP), as well as on cardiorespiratory fitness (peak oxygen uptake [VO₂peak]), and muscle strength (handgrip strength). The review also considers factors such as patient adherence, follow-up duration, and statistical significance to inform clinical practice.

Methods: This systematic review followed preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines and was prospectively registered in international prospective register of systematic reviews. PubMed, Google Scholar, OVID, and Web of Science …

Right Ventricular–Pulmonary Artery Coupling Predicts Early Myocardial Strain Improvement In Sglt2 Inhibitor-Treated Hfref, Mohammad Ali Hammad, Ramy Magdy Elgamal, Arwa Mohsen Abouelkhir, Osama Abouelfetouh Elshaer, Mohamed Shokry Fahmy, Reda Nabil Dawoud, Reda Biomy, Mohamed Kamal Salama

Journal of the Saudi Heart Association

Background: While sodium-glucose cotransporter-2 (SGLT2) inhibitors clearly benefit left ventricular recovery in heart failure with reduced ejection fraction (HFrEF), their rapid effects on right ventricular (RV) function remain poorly characterized. This prospective observational study investigated the timeline and markers of biventricular changes shortly after SGLT2 inhibitor initiation.

Methods:In this prospective observational study, 50 adults with HFrEF (LVEF

Results:After 3 months, NT-proBNP levels decreased significantly (1116.5 vs 913.5 pg/mL, P

Conclusions: In this prospective observational study without a control group, SGLT2 inhibitor initiation was associated with coordinated biventricular improvements within three months in HFrEF patients. The baseline TAPSE/PASP ratio …

Psychogastroenterology: An Introduction For Behavioral Health And Healthcare Professionals, Jerrod Brown Ph.D., M.A., M.S., M.S., M.S., M.S., M.S., Jeremiah B. Schimp Phd, Ma, Lpcc, Leanne Skehan Dcn, Msacn, Mph, Mba, Cns, Ches, Shelley Mydra Dmft, Lmft, Jonathan Ward Dc, Phd(C), Ms, Dibcn, Tiffany Flaten Cns, Ldn

Nutritional Neurocriminology Today

Although often difficult to discuss with clients, gastrointestinal (GI) issues affect an estimated 60 to 70 million Americans (American Gastroenterological Association, 2022). Yet only about 25% of those experiencing these conditions receive treatment. This is troubling because GI issues frequently co-occur with clinically significant consequences for physical health, psychological well-being, daily functioning, and overall quality of life. Designed for behavioral health and healthcare professionals, this brief article introduces the field of psychogastroenterology, with emphasis on symptoms, stigma, diagnosis, and treatment. Key topics include the gut-brain axis, common digestive health conditions, and the mental health implications associated with gastrointestinal disorders.

Acute And Inpatient Occupational Therapy Practice For People With Chronic Conditions Who Are Experiencing Homelessness, Emily K. Simpson, Anne K. Mokate, Elizabeth A. Gibbs, Nina K. Duric

Internet Journal of Allied Health Sciences and Practice

Purpose: Despite having high rates of chronic illness, people experiencing homelessness (PEH) in the United States face barriers to healthcare access that result in unmet health needs and poor health outcomes.  The objective of the study was to identify the barriers to service experienced by occupational therapy practitioners (OTPs) in acute and inpatient settings in providing services to PEH and to describe education strategies to reduce those barriers. Methods: Researchers employed a cross-sectional design with OTPs (n=292) with experience treating PEH. Results: Barriers to treatment for OTP included lack of education, need to prioritize acute concerns, and inadequate institutional resources. …

Living Through Misinformation: An Autoethnography Of Autism In Chinese Communities, Joy Lu

Ought: The Journal of Autistic Culture

This critical autoethnographic essay examines how misconception, misinformation, and disinformation shape understandings of autism within Chinese communities and produce tangible harm for autistic individuals and their families. Drawing on lived experience, advocacy work, digital observation, and cross-cultural analysis, it explores how language, medical practices, social media, and professional authority sustain persistent misrepresentation.

The essay argues that this misinformation is not merely the result of ignorance, but a socially reinforced and institutionally supported system of knowledge. By situating personal encounters within broader cultural and structural contexts, it highlights the interconnected roles of language, power, and exclusion in shaping autistic lives. It …

Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do

Journal for Sports Neuroscience

Abstract

Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.

Methods: A real-world clinical pilot …

Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman

Binghamton University Undergraduate Journal

Prior to the 1973 Roe v. Wade ruling, access to safe legal abortions was limited and often restricted along racial, economic, and geographic lines. Nearly fifty years later, women’s health policy evolved again following the 2022 Dobbs v. Jackson Women’s Health Organization decision overturning Roe v. Wade. This court ruling decimated federal protections of abortion. This paper presents the research that the 2022 Dobbs judicial decision may contribute to and exacerbate rape-related PTSD on 1 out of 20 American who are unable to access a safe abortion after a rape-related pregnancy. Pregnant women living in conservative states that have outlawed …

Comments On The Letter “Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Abdullah Saeed

Journal of the Saudi Heart Association

No Abstract for this article type.

Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Ahmed Almohammadi

Journal of the Saudi Heart Association

No Abstract for this article type.

Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs

Journal of Interprofessional Practice and Collaboration

The prevalence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing among adults aged 50 years and older in the United States, posing a significant public health challenge. In 2021, an estimated 38.4 million Americans had diabetes, with adults aged 50years and above constituting a disproportionately large segment of this population. Evidence suggests that community-based lifestyle and educational interventions are effective in reducing the risk of T2DM among older adults. These interventions particularly promote dietary modification, increased physical activity, and diabetes education. Integrating the expertise of nurses, dietitians, pharmacists, physicians, and other professionals through interprofessional collaboration strengthens diabetes prevention and …

Exploring Interprofessional End-Of-Life Communication Through Simulation: A Qualitative Study, Stephanie Jeffers Phd, Rn, Eric Stein Dsw, Lsw, Meg Hall Phd, Rn, Caroline Campbell Phd, Lsw, Carly King Msw, Lsw

Journal of Interprofessional Practice and Collaboration

Purpose: The purposes of this qualitative descriptive study were to understand the perceptions of nursing and social work students regarding communication with patients and families at the end of life and to explore the perceptions of nursing and social work students' regarding interprofessional roles at the end of life.

Methods: An interdisciplinary simulation about death and dying was conducted with 16 undergraduate nursing students and 3 graduate social work students to understand their perceptions regarding communication with patients and families at the end of life and to explore their perceptions of interprofessional roles. Simulations lasted approximately 20 minutes and were …

Evaluating Interprofessional And Cultural Competency: A Community-Mental Health Interprofessional Education Event, Megan A. Whitbeck, Carrie A. Griffiths, William F. Miller, Laura M. Skoronski Chavez, Krisy Elrod, Autumn M. Forgione, Anna L. Grippi, John P. Merchant

Journal of Interprofessional Practice and Collaboration

Purpose: This study examined the effectiveness of a mental health focused interprofessional education (IPE) event, where undergraduate and graduate students from four different healthcare disciplines collaboratively completed a case study activity, that included diversity and mental health components.

Methods: A quasi-experimental, one-group pretest–posttest design was used. Participants included 72 undergraduate and graduate students from nursing, occupational therapy, health administration, and counseling programs at a private university. Students engaged in a structured team-based activity emphasizing communication, collaboration, and cultural responsiveness in a mental health care context. Self-reported measures included the Interprofessional Collaborative Competency Attainment Survey (ICCAS) and the Cultural …

The State Of Interprofessional Education And Collaborative Practice In Ghana: Experts’ Perspective, Amy Bening, Victor Mogre, Yolande Heymans, Christmal Dela Christmals

Journal of Interprofessional Practice and Collaboration

ABSTRACT

Purpose: Interprofessional education (IPE) has gained recognition as the best form of preparing health professionals for Interprofessional Collaborative Practice (IPCP) in the healthcare settings. As such, many countries have inculcated IPE into the training of health professionals, but the state of IPE in the Ghana is unknown. Therefore, this study sought to explore the state of IPE and IPCP in Ghana.

Methods: The study employed a qualitative descriptive study in which 16 key informants were interviewed, and data was thematically analysed to describe the state of IPE and IPCP in Ghana.

Results: Three themes were identified and described: IPCP …

Community Health Fair As Experiential Learning: Interprofessional Faculty And Student Perspectives, Sharon Stevenson, Martha Rojo, Jing Jin, Erickson Feliciano, Margaret Love, Scott Wright

Journal of Interprofessional Practice and Collaboration

Abstract

Background: Traditional, precepted clinical practice sites continue to decline. Community health fairs (CHFs), led by experienced interprofessional faculty, present a valuable opportunity. In addition, CHFs provide students with hands-on experience in real-world settings.

Aim: This study examined the perspectives and clinical experiences of interprofessional faculty and students participating in a CHF.

Methods: This study utilized qualitative and quantitative design. Fourteen participants (seven students, seven faculty) engaged in conversational interviews, and completed a faculty and student survey as well as a demographic survey. Descriptive statistics were used to describe the sample and survey responses, and thematic analysis was used to …

Transforming Student And Patient Lives In Guatemala, Ryan J. Grippo, Jarett C. Worden, Lawrence B. Stack, Kamini V. Kabilan, Aakanksha S. Khadye, Edison Nwobi, Sydney G. Wisnefski

Cumberland Medica

Abstract: Interprofessional healthcare service-learning experiences provide the environment for transformative growth of students. Belmont University’s faculty from the Frist College of Medicine and the College of Pharmacy and Health Sciences created an interprofessional healthcare service-learning experience for medical students and pharmacy students. This experience includes providing hands-on care in community health clinics in Guatemala as well as touring healthcare facilities in Guatemala. This reflection article highlights the details of the inaugural session of this experience and the transformative quality of this experience from the student perspective.

Exploring The Dual Impact Of A Graduate-Led Physical Therapy Experience On Undergraduate Engagement And Graduate Professional Development: A Case Report, Ellie Trubey, Jennifer Bochynski, Michelle Slike

Internet Journal of Allied Health Sciences and Practice

Purpose: The significance of connectedness, motivation, and professional identity formation in healthcare education is well documented in recent research. The purpose of this case report is to evaluate the impact of an interactive, peer-led learning experience between graduate physical therapy students and undergraduate pre-physical therapy students. A specific focus is placed on identifying the effect this professional early-exposure event had on each group’s perceived connectedness to the program, motivation to continue studying physical therapy, and a developing professional identity. Methods: Graduate physical therapy students designed and facilitated a hands-on learning session for first-year pre-physical therapy undergraduates. Post-event surveys were used …

Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong

The Thai Journal of Veterinary Medicine

Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats …

Cross-Cultural Differences Among Children And Youth With Special Health Care Needs: A Mixed-Methods Analysis Of Chinese, Spanish, And English-Speaking Families, Kathleen Mcgrath, Miriam Franco, Amy Morales-Lara, Karen Bonuck Phd, Joanne Siegel

Developmental Disabilities Network Journal

One in five U.S. children has a special health care need, with prevalence rates rising each year. Children and youth with special health care needs (CYSHCN) from immigrant and/or non-English speaking families face heightened barriers to care, unmet health needs, and worsened health outcomes. This mixed-methods study explores cross-cultural similarities and differences among English-, Spanish-, and Chinese-speaking families of CYSHCN across four key domains – (1) the diagnostic process, (2) access to essential services, (3) community integration, and (4) social supports. As part of a statewide, New York State Department of Health funded initiative implemented across three University Centers for …

The Feasibility Of A Single Educational Intervention To Improve Caregiver Confidence In Stroke Rehabilitation, Angelica Fedorchak, Jennifer E. Lape

Internet Journal of Allied Health Sciences and Practice

Purpose: Caregivers play a critical role in providing support to stroke survivors during recovery, but they often face emotional, physical, and educational challenges that can lead to caregiver burden and burnout. Despite the significant impact education can have on caregivers, rehabilitation professionals in inpatient rehabilitation settings often struggle to provide comprehensive training due to time constraints and strict productivity standards. This feasibility study aimed to evaluate whether an individualized one-time caregiver education session, integrated into the discharge planning process, could enhance caregiver confidence and whether the necessary education could be practically integrated into the existing staffing, reimbursement, and organizational structure …

Designing Robust Physiotherapy Trials: When And How To Use The Randomized Crossover Model, Manish P. Shukla, Gaurav Chhabra, Ashish Shankarrao Deshmukh, Neha Sachin Chaudhary, Neha Deshmukh

Internet Journal of Allied Health Sciences and Practice

Problem: Physiotherapy research increasingly requires methodological precision and clinical relevance. Among available designs, the randomized crossover model offers distinct advantages by allowing each participant to serve as their own control, thereby reducing inter-individual variability and improving statistical efficiency. Purpose: This perspective article discusses how appropriately designed crossover trials can enhance the quality and interpretability of physiotherapy research when applied under stable clinical conditions and with adequate washout periods. Methods: Three representative crossover studies illustrate these principles across physiotherapy specialties. In musculoskeletal practice, manual therapy for thoracic pain demonstrated measurable reductions in paraspinal electromyographic activity following counterstrain compared with spinal manipulation. …