Medicine and Health Sciences Commons^™

Pediatric Covid-19 Encephalitis, Nelson D. Gonzalez, Dustin Paul, Ana Almeda, Samuel Serna, Linette Linsangan

Research Symposium

Background: Neurologic complications of COVID-19 in the pediatric population have been reported in a limited number of reports. There have been reports of COVID-19-associated encephalitis in pediatric cases along with neuroimaging findings revealing involvement of some parts of the nervous system. We present the first case of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - associated encephalitis targeting the parietal lobes.

Case: A 14-year-old morbidly obese Hispanic male with no past medical history presented to the hospital for new onset seizures. Family reported exposure to his COVID-19 positive mother, a one-week history of fever, and a three-month history of …

Osteomyelitis In Diabetic Foot Ulcer: A Common Dreaded Complication Of Dm, Gabriel J. Lora Ferreira, Carol Soler, Patrick Ojeaga

Research Symposium

Background: Group B ß-hemolytic streptococci is a rare offending agent in osteomyelitis with strong affinity for the diabetic foot. A high index of clinical suspicion, alongside radiological studies, should guide prompt diagnosis and treatment to avoid unfavorable complications.

Case Presentation: A 42-year-old obese gentleman with history of hyperlipidemia, hypertension, peripheral artery disease, depression with alcohol abuse, and recently diagnosed type 2 diabetes mellitus and peripheral neuropathy presented to the emergency department with worsening left foot pain for 2 weeks with a nonhealing necrotic ulcer. Upon presentation, he was in no acute distress with insignificant initial labs except for blood glucose …

Optimization Of A Non-Invasive Temporary Deafferentation Protocol To Improve Upper Extremity Rehabilitation, Victoria Cuello, Kelsey Baker

Research Symposium

Background: After a spinal cord injury neural structures that survive reorganize. The brain “ignores” past associations with weaker muscles below the level of injury so stronger, spared muscles take over cortical maps of weaker muscles. Temporary Deafferentation (TD) is a method that utilizes short-term anesthesia, such as over-the-counter lidocaine cream, to inactivate sensation pathways from stronger muscles so that the brain releases inhibition that was placed on weaker muscles, thereby strengthening them. There has been research supporting TD approaches to rehabilitation; however, there is not an established protocol to apply TD in a clinical setting. Here, we seek to optimize …

Novel Nanoparticle Formulation Of Sabizabulin (Veru-111) For Pancreatic Cancer Treatment, Vivek K. Kashyap, Godwin P. Darkwah, Neeraj Chauhan, Prashanth Kb Nagesh, Anupam Dhasmana, Swati Dhasmana, Qinghui Wang, Duane D. Miller, Wei Li, Bilal B. B. Hafeez, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus, developing novel therapeutic strategies will help for the management of this disease. We recently identified VERU-111, a novel synthetic molecule which showed potent anti-cancer effect against PanCa via targeting clinically important βIII and βIV tubulin isoforms. In this study, we synthesized and characterized its novel nanoformulation (MNP-VERU) and evaluated its therapeutic effects in vitro and xenograft mouse model.

Methods: MNPs were prepared by chemical precipitation method and loaded with VERU-111 using diffusion method. This formulation was …

Non-Alcoholic Fatty Liver Disease And Hepatocellular Carcinoma Risk Associated Gene Expression Phenotypes In Hispanics, Satish Kumar, Joanne E. Curran, Erica De Leon, Jose C. Granados, Ana C. Leandro, Marcelo Leandro, Juan M. Peralta, Sarah Williams-Blangero, John Blangero

Research Symposium

Background: Non-alcoholic fatty liver disease (NAFLD) is a state of metabolic dysregulation characterized by excessive lipid accumulation into the hepatocytes (hepatic steatosis). It is a major determinant of risk for hepatocellular carcinoma (HCC). Hispanics in south Texas exhibit one of the highest incidences of NAFLD and HCC in the United States.

Methods: We used an induced pluripotent stem cell (iPSC) based hepatocyte (HEP) model to identify high lipid stress induced transcriptomic changes in HEPs to better understand hepatic steatosis associated HCC risk. Well-characterized, iPSC differentiated functional HEPs generated from six participants in our San Antonio Mexican American family study were …

Natural Remedies To Combat Aberrant Hallmark Signatures Including Altered Glycosylation In Oral Carcinoma, Kruti A. Mehta, Jayendra B. Patel, Prabhudas S. Patel

Research Symposium

Background: Tobacco associated oral cancers remain a major concern in India with higher incidence and mortality making it an Indian-centric burning issue. To combat this dreadful disease, we investigated effects of certain natural compounds on the hallmark signatures including glycosylation transcripts levels in oral carcinoma.

Methods: The tongue carcinoma cells- SAS cells were treated with tobacco compounds, natural compounds and Cisplatin. RNA was isolated from the cells and converted to cDNA. RT-qPCR was performed to evaluate expression levels of various genes.

Results: The treatment of tobacco compounds resulted in similar pattern of altered makers (ST3GAL1, NEU3, FUT5, FUT6, MMP2, BCL2) …

Multiple Rsv Strains Infecting Hep-2 And A549 Cells Reveal Cell Line-Dependent Differences In Resistance To Rsv Infection, Anubama Rajan, Felipe-Andres Piedra, Letisha Aideyan, Trevor Mcbride, Matthew Robertson, Hannah L. Johnson, Gina Marie Aloisio, David Henke, Cristian Coarfa, Fabio Stossi, Vipin Kumar Menon, Harshavardhan Doddapaneni, Donna Marie Muzny, Sara Joan Javornik Cregeen, Kristi Louise Hoffman, Joseph Petrosino, Richard A. Gibbs, Vasanthi Avadhanula, Pedro A. Piedra

Research Symposium

Background: Respiratory syncytial virus (RSV) is the major viral driver of a global pediatric respiratory disease burden disproportionately borne by the poor¹. Thus, RSV, like SARS-CoV-2, combines with congenital and environmental and host-history-dependent factors to create a spectrum of disease with greatest severity most frequently occurring in those least able to procure treatment.

Methods: Here we apply whole genome sequencing and a suite of other molecular biological techniques to survey host-virus dynamics in infections of two distinct cell lines (HEp2 and A549) with four strains representative of known RSV genetic diversity.

Results: We observed non-gradient patterns of RSV …

Neurodegeneration Difference Between The Non-Lesioned And Lesioned Hemisphere In Stroke Patients, Nuvia Cortez, Elle Wynn, Kelsey Baker

Research Symposium

Background: Stroke is the 4th leading cause of death in Hispanics. It has generally been suggested that neurodegeneration is isolated to the lesioned hemisphere . However, recent evidence has suggested that the non-lesioned side of the brain may also undergo neurodegeneration. Here, we sought to evaluate the amount of neurodegeneration in the lesioned and non-lesioned hemisphere in chronic stroke patients and identify the impact of stroke size and location.

Methods:T1-weighted magnetic resonance imaging and diffusion weighted imaging (DWI) of the brain was collected in 23 patients with chronic stroke and 14 healthy controls. We quantified the amount of neurodegeneration …

My Achy-Breaky Heart: A Case Of Diffuse Large B-Cell Lymphoma Presenting As Impending Cardiac Tamponade In A Hispanic Woman, Christine E. Loftis, Rosa Guedez-White, Daniel Farray

Research Symposium

Background: Mediastinal masses can arise from typical structures within the mediastinal or they can develop secondary to metastasis from other organ systems [1] Primary mediastinal diffuse large B-Cell lymphomas (PMBCL) are uncommon, accounting for 7% of the cases of diffuse large b cell lymphoma. We describe a case of a 35-year-old woman who presented with atypical chest pain and shortness of breath and was diagnosed with PMBCL in the setting of impending cardiac tamponade.

Case Report: A 35-year-old woman with history of cutaneous lupus presented with an 8-month history of chest pain with associated worsening shortness of breath. Upon further …

Mutational And Expression Analysis Of Fbxw7 Gene In Colorectal Cancer Patients Among North Indian Population, Laraib Uroog

Research Symposium

Background: Colorectal cancer is the third most common cancer worldwide with the incidence rate of 1.8 million (10.2%) (GOBOCON-2018). CRC is endemic to Kashmir Valley due to both, kangri use and non-veg food habit. The current study was designed to explore the possible correlation between that FBXW7 and colorectal cancer progression.

Methods: FBXW7 gene mutations and expression was analyzed in 173 colorectal carcinoma tissues along with the adjacent non-cancerous matched tissues using polymerase chain reaction-single stranded confirmation polymorphism assay. Gene expression analysis was conducted using qRT-PCR, western blot and IHC.

Results: In total, six mutations were found …

Mucin Muc13 And Yap1 Correlate With Poor Survival In Colorectal Cancer, Sudhir Kotnala, Anupam Dhasmana, Kyle Doxtater, Meena Jaggi, Murali M. Yallapu, Manish Tripathi, Subhash C. Chauhan

Research Symposium

Background: Metastatic disease contributes to over 90% of cancer-associated deaths. Colorectal cancer (CRC), the second lethal malignancy, has the greatest incidence and mortality rates in the Southern United States. Over 40-50% of CRC patients acquire metastasis at some point throughout their disease's progression. CRC survival rate drops from 90%-14% when the disease is confined within the colon and therefore “early diagnosis” becomes imperative to determine timely and quality treatments. We have identified that MUC13 protein translocate to nucleus along with transcription factor Yes-Associated Protein 1 (YAP1) during anchorage independent conditions (metastatic phenotype). YAP1 is known to be overexpressed in CRC …

Mucin 13 Expression Is An Early Indicator Of Hepatocellular Carcinoma Development, Shabnam Malik, Mohammed Sikander, Deepshikha Pande Katare, S. Mishra, S. K. Jain, P. Khan, Subhash C. Chauhan, Meena Jaggi

Research Symposium

Background: Hepatocellular carcinoma (HCC) has a poor prognosis due to ineffective therapeutic modality and lack of an early marker for diagnosis. Studies show that increased mucin 13 (MUC13) expression as a possible oncogene and predictive biomarker for various cancers has been shown. But its expression and role in the development of HCC is very little known.

Objective: The aim of this study is to investigate the MUC13 expression in chemically induced hepatocellular carcinoma model.

Methodology: Male Wistar rats were subjected to a DEN and 2-Acetylaminofluorene (2-AAF) induced method for the development of hepatocellular carcinoma. Serum and tissues were collected at …

Mrna-1273 Covid-19 Vaccine Leading To Anti-Lgi1 Limbic Encephalitis Flare, Cesar A. Peralta, Ismael Polo, Siddanth Singh, Ronkino Mccoy, Jose E. Campo Maldonado

Research Symposium

Introduction: Here, we discuss a patient with a past medical history of Anti-LGI1 limbic encephalitis that presented with seizure-like activity approximately three weeks after the administration of the mRNA-1273 COVID-19 vaccine.

Case Description: A 75-year-old male with a history of Anti-LGI1 limbic encephalitis presented to our hospital with bilateral, truncal myoclonus and lateral nystagmus. EEG showed periodic lateralized epileptiform discharges. Brain MRI was unremarkable. The lumbar puncture was not suggestive of meningoencephalitis and the patient was diagnosed with a clinical relapse of Anti-LG1 limbic encephalitis, started on IVIG, methylprednisolone, azathioprine, and antiseizure medications. After the absence of seizure activity was …

Molecular Insights To The Dose-Dependent Activities Of Ashwagandha Extracts, Huayue Zhang, Jaspreet Kaur Dhanjal, Jia Wang, Ashish Kaul, Sunil C. Kaul, Renu Wadhwa

Research Symposium

Background: Stress is an inevitable component of life. Several herbs are known for their health supporting effects that range from treatment of stress, common cold to cancer. We investigated the dose-dependent effect of Ashwagandha (Withania somnifera) extracts on human normal and cancer cells, and have attempted to resolve the molecular mechanisms of their antistress activities.

Methods: Ashwagandha extracts were chemically profiled by HPLC. Cytotoxicity was determined by viability assays. Biochemical and immunoimaging assays were performed using specific antibodies.

Results: Human normal cells treated with low doses of the leaf extract or purified withanolides (Withaferin A or Withanone) showed no toxicity. …

Molecular Insights Into Targeting Pkd1 For Prostate Cancer Treatment, Mohammed Sikander, Shabnam Malik, A. Rodriguez, Aditya Ganju, Bilal B. Hafeez, Fathi T. Halaweish, Subhash C. Chauhan, Meena Jaggi

Research Symposium

Background: Prostate cancer has a poor prognosis due to late diagnosis and ineffective multimodal clinical treatment. Efforts are underway to create strategies for resolving the abnormal expression of molecular targets implicated in disease development and progression. We previously reported that the serine threonine kinase Protein Kinase D1 (PKD1) regulates a multitude of tumor suppressor functions, including cell aggregation, motility, proliferation, and invasion in prostate cancer. Thus, PKD1 is regarded as a promising therapeutic target for the treatment of prostate cancer.

Objective: The goal of this study was to investigate the therapeutic potential of ormeloxifene (ORM), a pharmacological modulator with well-defined …

Molecular Basis For The Pharmacological Activities Of Piperlongumine Against Breast Cancer: Role Of Glucose Import, Ros, Nf-Κb And Lncrnas, Nikee Awasthee, Anusmita Shekher, Vipin Rai, Sumit Singh Verma, Shruti Mishra, Subash Chandra Gupta

Research Symposium

Background: Piperlongumine (PL, piplartine) is an alkaloid derived from the Piper longum L. (long pepper) root. The activities PL against breast cancer and the underlying mechanism is not thoroughly investigated.

Aim: We examined the anti-cancer activities of PL against breast cancer cells. The molecular basis for the pharmacological activities of this alkaloid was also examined.

Methods: The breast cancer cell lines such as MCF-7, T-47D, MDA-MB-231, MDA-MB-468 and MDA-MB-453 were used during the study. We used MTT assay, clonogenic and soft agar colony formation assay for cytotoxicity. The cell cycle analysis, phosphatidylserine externalization assay, measurement of mitochondrial membrane potential, …

Mind, Body And Race: A Look Into How Implicit Biases Influence The Perception Of Emotion, Faiza Ahmad, Adam Anderson, James Dalton Rounds, Christina Chick, Alize Hill

Research Symposium

Background: Most research examining the effects of implicit race-based biases in emotion perception has focused on the perception of Black faces as being angry. Limited work has been done examining the perception of “approach” emotions such as fear. Furthermore, most studies have predominantly used White subjects. Our study examined the role of implicit racial biases in shaping the perception of both anger and fear in White, Black and Asian participants.

Methods: 78 participants completed a Go/NoGo task in which they were asked to categorize different race faces as portraying either anger or fear. Participants would be asked to press the …

Moans, Palpable Groin, And Entrapment Of Bone: A Case Of Malignant Peripheral Nerve Sheath Tumor In An Otherwise Healthy Hispanic Male, Nelson D. Gonzalez, Christine E. Loftis, Rosa Guedez-White

Research Symposium

Background: Malignant peripheral nerve sheath tumors (MPNTs) are rare malignant soft tissue sarcomas that have an incidence of about 0.001 %. MPNTs typically occur in individuals who have neurofibromatosis or secondary to radiation therapy and rarely occur sporadically. We present a case of a previously healthy 56-year-old gentleman who was diagnosed with MPNTs.

Case: A healthy 56-year-old gentleman presented with worsening LLQ abdominal pain for 6 months. Associated symptoms included bloating, LLE swelling, early satiety for the past 2 months, and a 5-10lb unintentional weight loss. Patient denied recent cough, night sweats, dyspnea, fever, chills, melena or hematochezia. Vitals were …

Microrna-145 Replacement As A Therapeutic Tool To Improve Trail Therapy, Sheema Khan, Saini Setua, Nirnoy Dan, Melida Flores Cantu, Ana Martinez Bulnes, Murali M. Yallapu, Stephen W. Behrman, Meena Jaggi, Subhash C. Chauhan, Sheema Khan

Research Symposium

Pancreatic cancer (PanCa) is a third leading cause of cancer related deaths in US. Unlike other cancers, PanCa is highly resistant to TNF-related apoptosis-inducing ligand (TRAIL) that emerges as one of the most-promising therapy in clinical trials. Our group has previously identified microRNA-145 (miR-145) is downregulated in PanCa, the restoration of which inhibits tumor growth and enhances gemcitabine sensitivity. In this study, we have observed that miR-145 restoration in PanCa cells renders them sensitive to TRAIL treatment. Therefore, we have engineered unique superparamagnetic nanoparticles (SPs) for co-delivering miR-145 and TRAIL in PanCa for improving their therapeutic response to TRAIL. The …

The Dysphagia Causing Cancer: A Case Of Oropharyngeal Squamous Cell Carcinoma, Rodolfo Singleterry, Khairiya Haj-Yahya, Ayman Khaddam, Karina Torres

Research Symposium

Introduction: Oropharyngeal squamous cell carcinomas (OPSCC) occur in approximately 123,000 cases of oropharyngeal cancer diagnosis worldwide and with about 79,000 deaths yearly. OPSCC stems from the soft palate, pharyngeal wall, tonsils, vallecula, and base of the tongue. Patients with metastatic head and neck squamous cell cancer have a generally poor prognosis noting a median survival of 6 to 15 months. Treatment with systemic therapy is used for most patients and is dependent on their clinical factors, comorbidities, previous treatments, and pathologic features.

Case Presentation: The patient is a 52-year-old male with a past medical history of liver cirrhosis, hepatitis C, …

Long Non-Coding Rna (Lncrna) As A New Biomarker For Hepatocellular Carcinoma (Hcc) Drug Resistance, Areeb Masood, Kyle Doxtater, Anupam Dhasmana, Subhash C. Chuahan, Sanjaya Satapathy, Manish Tripathi

Research Symposium

Background: Hepatocellular carcinoma (HCC) is the 4^th leading cause of cancer-related deaths worldwide and the 6^th most common cancer worldwide. When HCC progresses to advanced stages, drug resistance becomes a major hurdle and leaves clinicians with limited therapeutic options. Long non-coding RNAs (lncRNAs) have shown to promote drug resistance in various cancers. The goal of our research is to explain the molecular role of lncRNAs in HCC drug resistance and compile a comprehensive list of studied lncRNAs involved in HCC drug resistance.

Methods: To compile a list of lncRNA involved in HCC drug resistance we performed an advanced …

Malignant Colorectal Cancer In The Rio Grande Valley: A Demographical Study, Kevin M. Camstra, Vijian Dhevan

Research Symposium

Background: There is abundant demographical data available that provides an excellent general statistical overview of colorectal cancer (CRC) within the Hispanic population in South Texas. Much is known about the overarching trends regarding incidence, prevalence, mortality and screening rates among this specific population as compared to other racial and ethnic groups at the state and national levels. Despite our understanding of these broad trends, few studies have taken a step inward to provide a closer demographical analysis of a CRC population here in the Rio Grande Valley. In this study, we narrow the scope and take a closer look …

Ligand-Based Virtual Screening Of Sulfonamide Analogues For The Discovery Of New Carbonic Anhydrase Ii/Ix Inhibitors For Cancer Therapy, Edilsa Valenzuela

Research Symposium

Background: Carbonic anhydrase (CA) II and IX are overexpressed in numerous tumors associated with the hypoxic phenotype and have been involved in poor prognosis and cancer progression, which characterizes them as an attractive therapeutic target. The purpose of this study was to identify sulfonamide analogues as CA inhibitors based on affinity and interactions of molecular docking.

Methods: Through structure and similarity-based virtual screening and applying filters involving a preselection based on functional group, Lipinski's rule of five, mutagenic and tumorigenic characteristics, the best candidates were docked into the isoenzymes. Known reference ligands were used to determine affinity regions favorable for …

Investigating Monodelphis Domestica As An Alternative To The Mus Musculus As An Animal Model, Cristian M. Botello, John L. Vandeberg, Mario Gil

Research Symposium

Background: Mus Musculus is one of the first and one of the most widely used animal models in current neuroscience literature (Phifer-Riley & Nachmann, 2015). However, the research community needs alternatives to rodent models to study the mammalian brain. Research is needed to see if antibodies that target tyrosine hydroxylase, which are well researched in mice, can also be used to study the Monodelphis domestica brain.

Methods: Following transcardial perfusions and brain extractions, mouse and opossum brains were processed and stained for tyrosine hydroxylase (and with Nissl). Opossum brains will then be sliced and processed using IHC methods to compare …

International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad

Research Symposium

Background: Biochanin A, an isoflavone that is mainly present in red clover, has potent chemopreventive properties against many cancers. Ovarian carcinoma is fifth most common and deadliest gynaecological malignancy that causes the highest mortality in females worldwide. Hence a substantial need for new therapies for combating this gynaecological malignancy arises.

Methods: The present study aimed to investigate anti-cancerous potentials of biochanin A on cultured human ovarian carcinoma PA-1 cells through the cell viability assay, cellular apoptosis, disruption of mitochondrial membrane potential (MMP), involvement of ROS, cell cycle kinetics, and expression of apoptosis-related genes namely, p53, Bax, Bcl-2, Noxa and Puma. …

Learners Engaging With Hispanic Communities To Address Covid19 Inequities By Developing A Cultural Competence Guide For Public Health Messaging, Madeline Elaine Huff, Molly Chapman, Chasity Collier, Giuiseppe Fonseca Badillo, Shuchita Jhaveri, Ayesha Khan, Sabrina R. Orta, Zuni Ortega, Lina Pedraza Sanchez, Maria Pesantez Borja, Rosalind Reyes, Daniela Santos Cantu, Chelsea H. Chang

Research Symposium

Introduction: The Rio Grande Valley (RGV) has the highest rates of obesity and diabetes nationwide which have compounded the impact of COVID-19. We propose addressing underlying mistrust and systemic racism through a resident-and-student-learner-led, community-engaged, educational public health campaign targeting the Hispanic community in the RGV.

Methods: Twelve students were provided interdisciplinary leadership skills in a community-engaged public messaging campaign covering issues of COVID-19 inequities. Learners used these skills to engage with clinic community partners in qualitative interviews regarding the patient population to guide the creation of a culturally competent public health messaging rubric for the Hispanic community.

Results: Pre-intervention survey …

It’S Not Always Cellulitis: An Unusual Presentation Of Leukocytoclastic Vasculitis, Dina Hammad, Marco Thierry, Christine E. Loftis, Cesar Gutierrez

Research Symposium

Background: Leukocytoclastic vasculitis (LCV) is a histopathologic term for isolated cutaneous small vessel vasculitis (CSVV) without systemic involvement. LCV can be idiopathic or caused by medications, infections, vascular disorders or malignancies. The annual incidence of biopsy-proven leukocytoclastic vasculitis is approximately 45/million individuals. It presents as erythematous macules with palpable purpura bilaterally on dependent areas of the body. Unilateral and localized presentations are uncommon. Here, we present a rare case of isolated LCV on the abdomen.

Case Presentation: A 65 year old woman with a history of vitiligo and Raynaud’s Syndrome, presented with a 12 day history of a tender abdominal …

Inhibition Of Lipid Accumulation In Hepatocytes By Unique Ashwagandha Extracts, Dongyang Li, Huayue Zhang, Jia Wang, Ashish Kaul, Sunil Kaul, Renu Wadhwa

Research Symposium

Introduction: Ashwaganda (Withania Somnifera) is a popular ayurvedic herb, trusted for a variety of health benefits in Indian traditional home medicine system. Steroidal lactones, Withaferin A (Wi-A) and Withanone (Wi-N), have been characterized as its major bioactives with a variety of bioactivities. We investigated the effect of Ashwagandha extracts on steatosis, abnormal retention of fat within a cell or organ that often affects liver as non-alcoholic fatty liver disease (NAFLD).

Methods: We prepared extracts from Ashwagandha that varied in their Wi-A and Wi-N content. Cytotoxicity of these extracts on human hepatocytes (Huh-7 and Suit-2) was evaluated by cell viability assays. …

Incidental Chronic Lv Thrombus; A Dreaded Complication Of Anterior Mi, Gabriel J. Lora Ferreira, Benjamin Robalino

Research Symposium

Background: Left ventricular thrombus may develop after acute myocardial infarction and occurs most often with a large STEMI. The use of reperfusion therapy and fibrinolytics has dramatically reduced the incidence. Epidemiologic data suggest the incidence of LV thrombus is as high as 25% in patients with anterior MI. Risk of embolization has been reported up to 15% in patients without anticoagulation.

Case presentation: 70 y/o man with history of coronary artery disease with remote LAD stent placed over 17 years ago presents to the office as a new patient for evaluation of exertional shortness of breath and chest pain. Upon …

In Vitro Evaluation Of Phthalimide Derivatives Against Cancer Cell Lines, Crystel A. Sierra Rivera, Muhammad Kashif, Lenci Karina Vazquez Jimenez, Gildardo Rivera Sanchez, Alfredo Juarez Saldivar, Alma Delia Paz Gonzalez, Alejandro Zugasti Cruz

Research Symposium

Los cánceres de pulmón, próstata e hígado se encuentran entre los más prevalentes en los hombres. El cáncer de mama, de cuello uterino y de tiroides se encuentran entre los más prevalentes en mujeres (OMS, 2019). El tratamiento del cáncer generalmente incluye quimioterapia y radioterapia; sin embargo, los medicamentos contra el cáncer disponibles tienen una selectividad baja y causan efectos adversos graves, como nefrotoxicidad, neurotoxicidad y mielosupresión (Matsuo et al., 2010). Por tanto, el diseño y desarrollo de compuestos como nuevos agentes anticancerígenos frente a los tipos de cáncer de mayor incidencia son de vital importancia en el campo de …