Medicine and Health Sciences Commons^™

Effect Of Short Exposure Of Naoci/Edta On E. Faecalis In Extracted Human Teeth, Rylan N. Gustafson

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this project was to study the antibacterial effect of the short exposure of 5.25% NaOCl and 17% EDTA on eight strains of Enterococcus faecalis in extracted human teeth. The crowns of 240 single rooted teeth were removed and the canals were instrumented to ISO 0.36. The canals were irrigated with 5.25% NaOCl and 17% EDTA, autoclaved and separated into eight groups of 30 teeth consisting of 20 experimental teeth, 5 positive and 5 negative controls. Each group was inoculated with one of eight different strains of E. faecalis in BHl broth and incubated for four weeks. The …

Effect Of Gutta Percha On The Retention Of A Post Using Different Cements, Saeda H. Basta

Loma Linda University Electronic Theses, Dissertations & Projects

This study evaluated the effect of residual gutta percha on the retention strength of prefabricated post cemented with four different cements. Forty intact mandibular single canal canines or premolars were selected for standardized size and quality, endodontically treated, and decoronated to the cementoenamel junction. A post space was prepared to accommodate Para post XP size 4 (Coltene, Whaledent Inc., Cuy Falls, Ohio) to a depth of 8 mm. The Obtura heated gutta percha system was used to inject a very thin line of gutta percha along one lateral wall to the depth of the future post. Forty obturated teeth were …

Veneer Failure On Preveneered Primary Posterior Stainless Steel Crowns, Matthew H. Gustafsson

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: The purpose of this study was to determine the amount of force required to fracture or dislodge the veneered facings from three veneered lower primary molar stainless steel crowns (SSC) and to characterize the veneer failures.

METHODS: The following veneered crowns were used in this study: NuSmile crowns, Kinder Krowns, and EC crowns. Twenty lower right primary first molar crowns were used from each manufacturer, for a total of 60 crowns. All crowns were cemented with glass ionomer cement to a custom fabricated die. Twenty-four hours following cementation, each die with the cemented crown was placed into a custom …

Neuronal Connections From The Cervix To The Spinal Cord Before Parturition, Mary Medina Groves

Loma Linda University Electronic Theses, Dissertations & Projects

By the day before birth, the density of nerve fibers in the cervix has increased compared to earlier in pregnancy or in nonpregnant mice. Similar findings are reported in parturient women. To test the hypothesis that connections between the cervix and spinal cord are enhanced by term, the cervix of nonpregnant and time-dated pregnant mice (day 15 or 18 post-breeding) was injected with pseudorabies virus (PRV), a trans-synaptic retrograde neural tract tracer. Mice were euthanized and perfused 5 days later. The spinal cord and cervix were removed and postfixed overnight, immersed in sucrose, and cryostat sections through the thoracic to …

Cultural Beliefs About Health Professionals, Attributions For Mistreatment, And Continuity Of Cancer-Related Care, Jennifer Anne Tucker

Loma Linda University Electronic Theses, Dissertations & Projects

This research examined attributions for health care mistreatment, related emotions, and the role of cultural beliefs about health care professionals as determinants of cancer-related continuity of care among Anglo and Latino women in Southern California. This research was guided by Betancourt’s model of culture adapted for the study of health behavior (Betancourt & Flynn, 2008) and Weiner’s (1996) attribution theory of motivation and emotion. As predicted, higher levels of negative cultural beliefs about health professionals resulted in lower intentions for continuity of care indirectly through mediating psychological perceptions of intentionality for mistreatment, controllability of its causes, and anger toward the …

Novel Binding Domains Mediate Binding Of Hpv 16 E6 To Fadd And Procaspase 8, Sandy S. Tungteakkhun

Loma Linda University Electronic Theses, Dissertations & Projects

To evade the host response to infection, viruses have developed means to survive and propagate. HPV 16, a causative agent of cervical cancer and of some cases of oropharyngeal cancers, is one example. We have reported that the early viral protein E6 binds to proteins necessary for propagation of the apoptotic signal following receptor/ligand interactions, such as those mediated by FADD DED and procaspase 8 DED. E6 expression leads to the dose-dependent accelerated degradation of FADD and the protection of E6-expressing cells from Fas-induced apoptosis. Surprisingly, the splice isoforms of E6, E6_large and E6*, affect the stability of procaspase …

Mechanisms Of T Helper Cell Modulation In A Simulated Space Radiation Environment, Asma Rizvi

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure to solar particle events (SPEs) poses the most serious threat to astronaut health. Due to this radiation environment, exploration of the solar system beyond Earth’s orbit entails many risks for the crew on these deep space missions. Depression or dysfunction of the immune system is a major concern due to its high radio-sensitivity; potential consequences include overwhelming infection, development of cancer, fibrosis, and poor wound healing. Astronauts are also exposed to low dose/low dose rate (LDR) radiation. A three month stay at the international space station exposes them to ~ 0.05 Gy of radiation.

C57BL/6 mice received LDR gamma-radiation …

The Psychophysiology Of Information Processing Differences In Eating Disorders, Kathryn Grace Truitt

Loma Linda University Electronic Theses, Dissertations & Projects

Maladaptive or dysfunctional cognitive factors are believed to be significant contributors to pathology in eating disorders. The emotional Stroop task was used to examine [the] these dysfunctional cognitive factors. A sample of 31 women (14 nonclinical controls, 13 BN, 4 AN) participated in this investigation, after exclusion for ocular and movement artifacts and equipment problems the remaining sample contained 4 women diagnosed with BN, 4 women diagnosed with AN, and 9 matched non-clinical control subjects. Participants completed an Emotional Stroop task comprised of 8 blocks of words. On each trial, a word was presented in one of four colors (black, …

Application Of The Asset Mapping Model To Church Based Hiv/Aids Prevention And Control In Aba, Abia State, Nigeria, Godwin Nwadibia Aja

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined whether HIV/AIDS activities were more frequent among churches with needs and assets for HIV/AIDS prevention and control in Aba, Nigeria and whether this connection was mediated by collective efficacy. A cross-sectional design was used to obtain data in two phases. First, a three-step forum focus group discussion (FFGD) method was used to obtain data from 32 representatives of five denominations. Second, a quantitative survey questionnaire was constructed based on the result of the FFGD and the collective efficacy model. This questionnaire was administered to 830 members aged 18 years and above from 83 churches that had operated …

Precision Of Temporary Anchorage Device Placement With 2d Vs. 3d Diagnostic Tools And Surgical Guides, Howard Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Current methods of temporary anchorage device (TAD) planning and placement are performed by radiographic analysis in a two-dimensional plane that lends itself to inaccuracy secondary to variations in the angle from which the radiograph is taken, as well as the magnification of the radiographic image, resulting in an increased likelihood of placement errors. The purpose of this study was to compare a three-dimensional (3D) TAD planning and placement technique to a traditional two-dimensional (2D) technique. In the 2D group, periapical radiographs and pre-fabricated wire guides were used for planning and placement of TADs on five plastic models. For the 3D …

Influence Of Mandibular Fixed Retainers On Diagnostic Quality Of Cranial Mri, Norman E. Carter

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the diagnostic quality of MR images taken on subjects with different types of orthodontic lingual retainers in place. The study provides guidelines and recommendations for use of lingual retainer materials in those patients who are or may potentially undergo routine magnetic resonance imaging. Ten subjects had impressions taken and models made for retainer tray fabrication. Removable trays with each lingual retainer material incorporated in them were fabricated from the models. Subjects underwent scans with each of the five test trays in place. T1 sagittal (T1), T2 axial (T2), gradient echo (GRE), and …

Radiation-Induced Glutamate Transport Alterations In Neuron-Astrocyte Coupling, Martha Celia Sanchez

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure of the central nervous system (CNS) to ionizing radiation is known to result in behavioral, cognitive, and motor deficits - effects similar to those seen in many neurodegenerative disorders. Neurons and astrocytes, two principal cell types in the brain, coexist as an interdependent metabolic unit via the neurotransmitter glutamate. Disruption of this metabolic coupling would have widespread effects within the CNS, therefore it is hypothesized that ionizing radiation impairs glutamate transport and metabolism, and increases oxidative stress, ultimately impairing neuron-astrocyte coupling. We propose to investigate the mechanism and determine the impetus for radiation-induced neurotoxicity by measuring the temporal sequence …

Memory For Emotional Images : Recognition And Temporal Contexts, George E. Devore

Loma Linda University Electronic Theses, Dissertations & Projects

Negative emotional stimuli are usually better remembered than neutral emotional stimuli. Previous examination of binding theory found no differences in recall for homogeneous lists of taboo and neutral words. The current study expands on binding theory using negative and neutral visual stimuli in homogeneous lists. A rapid serial visual presentation paradigm and recognition and temporal memory item-discrimination tasks were used. Binding theory predicts no differences between negative and neutral images for recognition and temporal memory. Results were consistent with the assumptions of binding theory and no significant differences were found. This result suggests that binding theory generalizes for visual stimuli …

Infant Feeding Decisions Among Pregnant Black Wic Participants And The Role Of Peer Support, Astrid D. Mickens

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to identify the important factors that impact infant feeding decisions among Black women, and to determine whether peer support influences the relationship among theoretical constructs of the social learning theory. A convenience sample of 110 Black pregnant women, ages 18-45, attending Women, Infant and Children (WIC) clinics throughout Riverside and San Bernardino Counties were recruited to participate in the study through the Nutrition Services Department. Eligible participants included pregnant Black WIC clients in any stage of pregnancy.

The survey questions contained information about perceived support, cognitive knowledge, abilities and beliefs regarding breastfeeding. The goal …

Efficacy Of Cognitive Therapy And Pharmacotherapy In Depression: A Meta-Analysis, Daniel B. Michel

Loma Linda University Electronic Theses, Dissertations & Projects

A meta-analysis comparing the long-term effectiveness of cognitive behavioral therapy (CBT) and pharmacotherapy in preventing relapse following treatment discontinuation was performed using published studies of depressed participants. Twenty-three articles met inclusionary criteria and were included in the analyses. Weighted effect sizes and moderators, treatment type, were calculated using statistical analysis software. Initially, fixed effects models were applied to the data, but due to significant between-group heterogeneity that could not be fully explained by treatment type, mixed effect models were used to account for the residual heterogeneity. Results indicated that overall, depressed individuals treated to remission with CBT evidence decreased relapse …

Immediate Implant Placement In Extraction Sites With Periapical Lesions: A Retrospective Study, Yuan-Lung Hung

Loma Linda University Electronic Theses, Dissertations & Projects

Immediate implant placement into fresh extraction sites has become a relatively routine clinical procedure with a favorable prognosis. However, immediate placement into extraction sockets with lesions has not been extensively documented in humans. Therefore, the purpose of this study was to retrospectively determine the survival rate of implants placed into extraction sockets with visible periapical lesions.

Patient charts of 544 immediately placed implants from Loma Linda University School of Dentistry, Center for Prosthodontics and Implant Dentistry were examined. Eighty-six of the 544 implants had been placed immediately into extraction sockets with periapical lesions and they were included in this study. …

Is Electrical Stimulation A Predictive Tool For Autonomic Dysfunction In Males With Diabetes?, Susan Dorothy Rand

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to examine whether electrical stimulation can be used as a predictive tool to assess autonomic dysfunction in males with diabetes. The study was designed to better understand the extent of autonomic nervous system (ANS) dysfunction in the diabetic population.

Controls and patients with diabetes were recruited from the community at large and the Loma Linda University Diabetes Treatment Center and were managed by a physician. Twelve (12) people with diabetes and thirteen (13) control subjects participated. Mean age (years) for people with diabetes was 52.4 +/- 6.1 and 47.2 +/-11.1 for controls (p =0.05). …

Distraction Of Heterotopic Bone Formed With Bmp-2 In A Rat Model: The Technique, Stacie Dawn Fenderson

Loma Linda University Electronic Theses, Dissertations & Projects

Multiple studies have shown that ectopic bone forms when bone morphogenic proteins (for example BMP-2 and BMP-7) and a collagen matrix are surgically placed in a rat model either orthotopically or heterotopically. Bone begins to form by the 14 day, and is at it maximum calcified state by the 21st day. The purpose of this study is to observe and quantify the effect of distraction osteogenesis on the ectopic bone. First, a preliminary procedure was performed by surgically placing a titanium cage into the back of a rat just caudal to the thoracic vertebrae. The anterior corners were sutured to …

The Effects Of The Quadhelix Appliance On The Dentition And Adjacent Buccal Bone, Shannon Hilgers

Loma Linda University Electronic Theses, Dissertations & Projects

Maxillary palatal expansion has long been used in orthodontics as a means of correcting constricted and collapsed dental arches. The quadhelix appliance, developed by Drs. Robert Ricketts and Ruel Bench, expands buccal segments and causes distobuccal rotation in upper first molars. The objective of this study was to assess the direct effects that the quadhelix appliance on the surrounding dentition and buccal bone in the maxillary premolar and molar areas in a finite, measurable manner. This assessment was made using the NewTom 3G. The pre-quadhelix and post-quadhelix NewTom 3G images of twenty patients treated in the Graduate Orthodontic Clinic at …

The Skeletal Effects To The Maxilla After Rapid Maxillary Expansion Using Cbct, Brett J. Garrett

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to use cone beam computed tomography (CBCT) to quantitatively evaluate and compare skeletal expansion and alveolar tipping of the maxilla at the maxillary canine (Cl), first premolar (PI), second premolar (P2) and first molar (Ml) after rapid maxillary expansion (RME). Transverse effects to the maxillary suture, nasal width and maxillary sinus were also assessed. Included in the study were thirty consecutive patients (17 males and 13 females; mean age = 13.8 + 1.7 years) requiring RME using Hyrax appliances as part of their comprehensive orthodontic treatment. The pre-RME and post-RME measurements of palatal and …

The Role Of Nogo-A During Development Of The Chick Central Nervous System, Shelly A. Caltharp

Loma Linda University Electronic Theses, Dissertations & Projects

Nogo-A is a potent inhibitor of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during embryonic development. To examine its potential role we isolated and analyzed the Nogo-A sequence in the chick, we localized its mRNA expression pattern and cell-specific distribution during key phases of cortical development, and studied regulation of its expression during phases that showed promise of function based on expression patterns.

Our results revealed five previously undescribed Nogo-A specific …

Effects Of Distress On Health Care Utilization In Cancer Survivors (Nhis 2004), Natalie Christine Kaiser

Loma Linda University Electronic Theses, Dissertations & Projects

Distress rates have been found to be around 43%, as indicated by a study of five comprehensive cancer centers and as measured by the Distress Thermometer (Jacobsen, et ah, 2005). Furthermore, few studies have examined the current health care utilization among cancer patients as predicted by distress. Thus, population-based data from the NHIS (2004) was analyzed using SUDAAN software 1) to ascertain the current levels of distress as measured by the Kessler 6 scale experienced by cancer survivors based upon demographic characteristics, family structure, physical comorbitities, and cancer-related variables, and 2) to determine whether distress rates reported among cancer survivors …

Physiological Effects Of Vibration In Select Populations, Colleen S. Maloney-Hinds

Loma Linda University Electronic Theses, Dissertations & Projects

Recently, researchers have demonstrated that Whole Body Vibration results in significant increases in skin blood flow. No study has determined if there is an optimal frequency or duration for optimizing this response. In addition, there is no known mechanism for the increase in skin blood flow. It is hypothesized that nitric oxide (NO) is responsible for the increase in skin blood flow due to its ability to vasodilate the smooth muscle in response to shear stress. Therefore, the purpose of this research was to determine the optimal frequency and duration of vibration and determine if NO is the mechanism for …

Predictors Of Emotional Reactions In Women Treated For Breast Cancer, Erin E. Ramirez

Loma Linda University Electronic Theses, Dissertations & Projects

Breast cancer can be a devastating disease that impacts a woman in all spheres of her life (Ingram, 1989). Previous studies have examined the impact of breast cancer on body satisfaction, as well as the impact on emotional well-being. Studies have also examined the role of the coping style that a woman engages in response to the diagnosis and treatment of breast cancer in the woman's psychological adjustment to the disease. However, to date, no research has introduced and tested a multifaceted model.

The purpose of this study was to develop a model predicting psychological maladjustment in women treated for …

A Model For Preventing Anorexia In College Students, Laura Ann Negin

Loma Linda University Electronic Theses, Dissertations & Projects

The prevalence of anorexia nervosa in the general population is relatively low, but anorexia is at the forefront of health concerns because of its seriousness. Unhealthy weight loss has numerous physical, psychological, and social consequences. Most seriously, the mortality rate for people with eating disorders is the highest of all the major psychiatric disorders.

This dissertation presents a model for preventing anorexia nervosa in a population of college students that includes a comprehensive institutional approach, psychoeducational software, a high-risk population, a holistic approach that identifies an individual’s personal risk factors and protective factors, and individual therapy.

The model is built …

Detection Of Simulated Apical Root Resorption Using Three Cone Beam Ct Machines, Marcus Paulson

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine orthodontists' ability to discriminate small differences of simulated apical root resorption (SARR) on extracted teeth, using the output from three cone beam computed tomography (CBCT) machines. Twenty-four unrestored maxillary anterior teeth exhibiting normal morphology, were collected. The teeth were scanned by three CBCT machines: 1) the NewTom 3G (AFP imaging, USA), 2) the iCAT (Imaging Sciences, USA) 3) and the MicroCAT II (Siemens Medical, USA). Using a sandblaster the apical portion of each tooth was reduced in 0.5 mm increments up to a total reduction of 1.5 mm. Each root modification was …

The Effect Of Mtad On Eight Strains Of E. Faecalis In Contaminated Root Canals, Bradley M. Newberry

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this investigation was to determine the antimicrobial effect of Biopure MTAD (a mixture of a tetracycline isomer, an acid, and a detergent) as a final irrigant on eight strains of Enterococcus faecalis (E. faecalis) in contaminated root canals of extracted human teeth. In addition, the Minimum Inhibitory Concentration (MIC) and Minimum Lethal Concentration (MLC) of MTAD were also measured on the same strains of bacteria. Two-hundred and forty extracted human teeth were instrumented using 1.3% NaOCl followed by 17% EDTA to remove the smear layer. The teeth were randomly contaminated with one of eight strains of E. …

Behavioral Compliance And Verbal Intelligence In Children, Jared Jackson

Loma Linda University Electronic Theses, Dissertations & Projects

Compliance with parental requests is an important developmental task necessary in the socialization of children. The majority of research has focused on the relationship between child compliance and variables related to age, parental interactions, and child temperament. While these variables account for almost half of the variance related to compliance in children, there is still a large amount of variance unaccounted for. An area that has not been fully explored is the role of verbal intelligence in behavioral compliance of children. This study explored the contributions that verbal intelligence may play in the behavioral compliance of children. Results from this …

Predictors Of Emotional Reactions In Women Treated For Breast Cancer, Erin E. Ramirez

Loma Linda University Electronic Theses, Dissertations & Projects

Breast cancer can be a devastating disease that impacts a woman in all spheres of her life (Ingram, 1989). Previous studies have examined the impact of breast cancer on body satisfaction, as well as the impact on emotional well-being. Studies have also examined the role of the coping style that a woman engages in response to the diagnosis and treatment of breast cancer in the woman's psychological adjustment to the disease. However, to date, no research has introduced and tested a multifaceted model.

The purpose of this study was to develop a model predicting psychological maladjustment in women treated for …

Predictors Of Female Sexual Dysfunction, Julie M. Merrell

Loma Linda University Electronic Theses, Dissertations & Projects

Tiefer, Hall, and Tavris (2002) described factors comprising four categories of female sexual dysfunction. They suggested that unique factors need to be examined to understand sexual dysfunction in women. Socio-cultural, political, or economic factors, partner and relationship factors, psychological factors, and medical factors described as aspects of women’s lives that can be the source of sexual dysfunction. The current study examined indicators of the above factors-body shame, relationship satisfaction, sexual self-schema, positive and negative affect, and overall health-as predictors of female sexual dysfunction. The hypotheses were: Body shame and negative affect will be negatively associated with sexual function; and relationship …