Medicine and Health Sciences Commons^™

Children With Autism: Sleep Problems And Predictors Of Maternal Stress, Cindy Y. Nam

Loma Linda University Electronic Theses, Dissertations & Projects

Research examining the impact of children’s autism and the sleep problems frequently associated with the disorder on parents’ stress has been quite limited. Studies have been constrained by methodological problems, including small sample sizes and the examination of children of autism within larger groups of children with a range of developmental disabilities. Typically, diagnostic criteria used to select children for an autism study is not indicated and no measure of the severity of children’s symptomology is included. The present investigation was designed to examine children’s autism symptomology and parents’ reports of their children’s sleep problems as well as the parents …

Posttraumatic And Parent Stress In Parents Of Infant Heart Transplant Recipients, Jessie Rose Stevens

Loma Linda University Electronic Theses, Dissertations & Projects

Heart transplantation during infancy is a life-threatening event, and when successful, the treatment is a life-long process and the potential for life-threatening consequences never ceases. As a result, parents can be impacted in many ways by this traumatic and demanding experience that begins with the initial diagnosis of their infant and continues into the long-term life course of these children. This life-long process has the potential to cause symptoms of posttraumatic stress disorder as well as elevated levels of stress in parents. This study examined parental self-reported post-traumatic stress symptoms and parental stress in parents of children who received a …

Religious Coping And Depression In Home Care Patients, Kirsten Ingheim

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the impact of a medical illness in 36 elderly male and female home health care patients with a primary diagnosis of heart disease, cancer, diabetes, or chronic obstructive pulmonary disease (COPD) and how they coped with their medical condition. Relationships between depression and religious coping, functional status, quality of life, and depression, as well as relationship between functional status and quality of life were investigated. In addition, a moderating effect of the relationship between functional status and depression by religious coping was explored. The participants completed the Religious Problem-Solving Scale (RPSS) (Collaborative, Deferring, and Self-Directing), the SF-12 …

Consider The Source : The Effects Of Adult Sources Of Human Immunodefciency [Sic] Virus And Sexually Transmitted Infection Prevention Information On Teen Risk Behaviors For Sexually Transmitted Infection, Janet E. Flores

Loma Linda University Electronic Theses, Dissertations & Projects

Sexually transmitted infections (STIs), including the Human Immunodeficiency Virus (HIV), are major health problems for adolescents, who represent over 26% of new cases of STIs diagnosed annually in the United States. Half of all HIV cases in people under age 25 result from sexual transmission during adolescence. Adolescent STI prevention is a national priority for the United States, and parents, schools, and medical providers, among others, are expected to have the greatest impact on adolescent STI risk reduction in teens.

This study used secondary Youth Risk Behavior Surveillance Survey (YRBS) data to explore the prevalence of high school students with …

Salivary Characteristics In 3 And 4 Year-Old Children With And Without Visible Caries, Gloria Yañez

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To compare salivary characteristics in 3 and 4 year-old Head Start children with and without visible caries.

METHODS: This case-control study was performed on 84 healthy 3 and 4 year-old Head Start children. After consent and inclusion criteria were met, each child was screened and assigned to one of two test groups based on their caries status. Group 1 consisted of children with no visible evidence of caries, although non-visible caries may have been present. Group II consisted of children with visible evidence demonstrating three or more carious lesions. Each child's unstimulated and stimulated whole saliva samples were collected …

Emotional Stroop Effects: Eating Disorders And Obesity, Kristy Anne Kuehfuss

Loma Linda University Electronic Theses, Dissertations & Projects

This study addresses the effects of emotional valence on selective processing of body-shape related words in young women who suffer from anorexia, bulimia, or obesity, and non-clinical controls. Research in the area of emotional Stroop interference has indicated that persons with eating disorders, particularly anorectics, show elevated latencies in naming colors of words related to food or body-shape, in contrast to either neutral words, or to non-clinical control groups. One intriguing issue regarding the emotional Stroop interference among various clinical populations relates to the question of whether the interference is due to the emotionality of the relevant words or to …

The Relations Of Pain, Religious Coping, And Depression In Fibromyalgia Patients, Derek O. Bacchus

Loma Linda University Electronic Theses, Dissertations & Projects

This study attempted to examine the relationship between Fibromyalgia Syndrome (FMS) pain, religious coping, and depression. The Fibromyalgia Impact Questionnaire (FIQ), Short-Form McGill Pain Questionnaire (SF-MPQ), RCOPE, and the Center for Epidemiologic Studies Depression Scale (CES-D) were used to assess these constructs in 50 participants. The sample was primarily middle aged and female, which is typical of the FMS population. This study used multiple regression to make assumptions about the causal progression of the variables. Study findings show that religious coping does not appear to significantly mediate the strong relationship between FMS pain and depression. This research served to uncover …

Female Patients’ Perspectives On The Stages Of Eating Disorder Recovery, Cherish C. Knoll

Loma Linda University Electronic Theses, Dissertations & Projects

Eating disorders are severe psychiatric disorders that most commonly begin in the female population during adolescence and across ethnicity (Lucas, 2004). However, the face of eating disorders is changing as they become more apparent across cultures and lifespan, impacting both young and aging women as well as males. In the past few decades progress has been made in the diagnostic, treatment, and recovery phases of eating disorders. These gains have contributed to a better understanding of eating disorders, assisting in the decrease of mortality and morbidity rates seen in eating disorder patients. Nevertheless, there are significant challenges that still remain …

The Effects Of Communication On Adolescent Sexual Behavior In Eastern Europe, Sharon Mieras Perugini

Loma Linda University Electronic Theses, Dissertations & Projects

HIV/AIDS rates have continued to rise in Eastern Europe where adolescents are particularly vulnerable. The theory of reasoned action (TRA) has successfully been applied to understanding adolescent sexual risk behavior and provides a theoretical framework for the prevention of HIV/AIDS. According to TRA, attitudes and subjective norms predict behaviors via the mediating role of intentions, and in order to have an impact on behavior, changes must occur at the attitude and subjective norm level. Because parents have been found to influence their children's attitudes, subjective norms, and intentions, the moderating effects of parent communication on sexual risk behavior of adolescents …

Comparison Of Laser And Phosphoric Acid Etching On Sealant Shear Bond Strength, Seth David Latimer

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To compare the effect of traditional phosphoric acid etching with Er,Cr:YSGG laser enamel etching on the shear bond strength of sealant material.

METHODS: Extracted healthy third molars were mounted in acrylic exposing the flattest surface available. Three groups of twenty teeth were used to evaluate traditional acid etching with 37% phosphoric acid as a control group as well as two different laser settings. The sealant material was attached using specialized jigs and then subjected to shear bond strength testing utilizing the ultradent method (MTS machine). Statistical methods employed were the Kruskal-Wallis rank test and the Mann-Whitney U test.

RESULTS: …

Electromagnetic Differences In The Brain During Memory Retrieval, Warren Scott Merrifield

Loma Linda University Electronic Theses, Dissertations & Projects

The primary objectives for this experiment were to analyze the neuroanatomical correlates of autobiographical, episodic and semantic memory, use a different paradigm to promote episodic memory retrieval, and employ a different analysis technique to understand retrieval processes. Autobiographical and episodic memories are personal memories from the past. Autobiographical is more general (e.g. a street name of a house growing up) and episodic is more specific to time (e.g. 13th birthday party that took place on a street). For autobiographical and episodic memory retrieval operations, there is no general consensus as to the localization of function, but bilateral activation of the …

A Microleakage Study Of Cements With Stainless Steel Crowns, Heidi Joy Apuy

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To compare the ability of newer adhesive resin cements and traditional glass ionomer cements to prevent microleakage under stainless steel crowns on extracted permanent third molars.

METHODS: All teeth were hand prepared and stainless steel crowns were cemented according to manufacturers' instructions. The specimens were thermocycled for 500 cycles and immersed in 2% methylene blue dye solution for 8 hours. Each tooth was imbedded in resin and cut into I mm thick sections by a slow speed diamond saw. The amount of microleakage was measured in microns under a traveling microscope. The measurements of each section of a tooth …

Factors Associated With Aids Risk Behaviors Of African Born Adolescents In Southern California, Dixon Anjejo

Loma Linda University Electronic Theses, Dissertations & Projects

The study was aimed at determining if cultural beliefs are salient factors contributing to the spread of HIV/AIDS among African born adolescents aged 15 to 19 years living in southern California. We used a cross-sectional design and collected data in two phases. The first phase was qualitative and data were collected from 25 participants in focus groups. The second phase utilized a questionnaire which was developed from the results of the focus group, using the theory of planned behavior. One hundred and thirty-five black African born teenagers between the ages of 15-19 years living in southern California completed the questionnaire. …

A Qualitative Study Of Inpatient Rehabilitation Client Perceptions Of The Semi-Fixed Environment, Liane Hewitt

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose. Literature supports the importance of the environment on promoting or compromising health. However, little is known about how the semi-fixed environment affects client perceptions and recovery from a debilitating condition. The purpose of this study was to investigate beliefs about control within the semi-fixed environment and client perceptions of the rehabilitation process.

Design and Method. This study utilized a basic qualitative research design with 10 rehabilitation clients whose average inpatient length of stay was 14 days. Data were collected in two phases. Phase I included two inpatient visits involving semi-structured interviews on the rehabilitation process and …

Effect Of Polishing Brushes On Dental Composite Resins, Robert Shun-I Wang

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: The effectiveness of many commercially available composite finishing and polishing devices have been studied and compared. However, no studies have directly compared the effectiveness among the polishing brushes. This study set out to (1) investigate the surface roughness reduction and gloss value increase of two universal dental composites polished by three polishing brushes and two well-studied finishing and polishing systems, and (2) to evaluate resulting surface morphology using scanning electron microscopy (SEM).

METHODS: 10 specimens were fabricated for each of five polishing groups for both composite resins, one microhybrid (Herculite XRV) and one nanofilled composite (Filtek Supreme Plus). Each …

Biochemical Characteristics Of Inconsistent Free T₄ Assays, Kristofer S. Fritz

Loma Linda University Electronic Theses, Dissertations & Projects

Serum levels of free thyroxine (T₄) are helpful in the clinical evaluation of patients who are suspected of having thyroid disease, since free T₄ (unbound) is known to closely relate to hyper, eu and hypothyroidism. There are documented inconsistencies among commercially available direct free thyroxine immunoassays. The biochemical basis for these inconsistencies is not understood and has not been characterized. Direct free T₄ measurements have been linked to both T₄-binding serum protein concentrations and protein-bound T₄ concentrations. A free T₄ reference method using direct equilibrium dialysis radioimmunoassay has been well characterized. New …

The Effect Of Radiation And Repeated Sub-Culturing On Tgf-Β1 Signaling In Frtl-5 Cells, Cheryl G. Burrell

Loma Linda University Electronic Theses, Dissertations & Projects

From our ongoing in vitro studies using the Fisher Rat Thyroid cell line-5 (FRTL-5) we recorded accelerated growth, reduced follicularization and reduction in thyroxin release that occurred as the cells were repeatedly sub-cultured. We also recorded that these changes occurred earlier and more rapidly following radiation exposure. We determined that TGF-β1 production increased under both conditions. We hypothesized that alteration in the TGF-β1 signaling pathway contributed to the changes observed in the cellular properties of FRTL-5 cells. Our objective was to examine some of the players in the TGF-β1 signaling pathway to determine whether radiation and/or repeated subculturing promoted changes …

Reproducibility Of Two Non-Consecutive Scans Using A Newtom 3g; In Vitro Model, Hyoung Jin Park

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The aim of this study was to evaluate the reproducibility of mineral density measurement expressed in Hounsfield Units (HU) using a phantom device with known mineral densities and the NewTom 3G Cone Beam Computerized Tomography (CBCT).

Materials and Methods: A phantom device made of 21 HA cylindrical disks with known densities was fabricated. The phantom was scanned in 6, 9, and 12 inch fields of view using a NewTom 3G CBCT. The scans were repeated at non-consecutive sessions. Volumetric data in each of the scans were formatted to DICOM images. HU values of the regions of interest were retrieved …

Radiation-Induced Increases In Pkc Modulate Integrin Expression And Contribute To Fibrotic Changes, Pinal Rushikesh Pandya

Loma Linda University Electronic Theses, Dissertations & Projects

The sequences of events in fibrosis are similar to those in wound healing; however, the normal termination and resolution stages do not take place. The initial cellular response following ionizing radiation involves accumulation of the ECM (extracellular matrix) including collagen, fibronectin and the interaction of many growth factors (cytokines) with their receptors. There are a number of unanswered questions regarding many aspects of radiation-induced fibrosis, including the initial triggers and physical changes that initiate the process. We have confirmed that elevated pKC and other cellular changes following radiation are similar to those found at sites of inflammation. This information leads …

Detoxification Of Lipopolysaccharide By Endodontic Sealers, Dominic Côté

Loma Linda University Electronic Theses, Dissertations & Projects

Bacterial lipopolysaccharide (LPS) has been implicated in the pathogenesis of pulpal and periapical diseases. Several studies have evaluated the ability of various medicaments and irrigants used during root canal therapy to chemically detoxify LPS. The purpose of this study was to evaluate the ability of some endodontic sealers to detoxify LPS. This investigation compared the quantities of TNF-α released by human monocytes exposed to LPS or LPS pre-treated with sealers. The sealers tested were: Pulp Canal Sealer EWT (PCS), AH Plus (AH), and Sealapex (SA). Ca(OH)₂ and water (H2O) were respectively used as the positive and negative control materials. …

Maturational Changes In Cerebrovascular Thick- And Thin-Filament Regulation, Renan Joel Sandoval

Loma Linda University Electronic Theses, Dissertations & Projects

The present study focused on the main hypothesis that age-related changes in myofilament Ca²⁺ sensitivity involve simultaneous changes in the relations between cytosolic Ca²⁺ transients, myosin phosphorylation, and force development. To define the effects of late fetal and early postnatal maturation, parallel experiments were carried out using cerebral arteries from both term lamb fetuses (140-141 days of gestation) and nonpregnant adult sheep. Fetal and adult cerebral arteries were stimulated by either mechanically, electromechanically, and/or pharmacomechanically-induced contractions, and the relations of cytosolic Ca²⁺, MLC phosphorylation, and contractile tensions were measured. These measurements allowed for stimulus and age-dependent …

Iron Dysregulation And Inflammation In Alzheimer’S Disease, Shino D. Magaki

Loma Linda University Electronic Theses, Dissertations & Projects

Alzheimer’s disease (AD) is the most common form of senile dementia in the US and worldwide but the causes of its pathogenesis are currently unknown. In this study, we examined two processes that have been implicated in the early stages of AD and other forms of neurodegeneration, iron dysregulation and inflammation, both of which can promote the increased production of amyloid precursor protein (APP). We have measured different pools of brain iron in transgenic iron regulatory protein 2 knockout (IRP2-/-) mice in the early stages of neurodegeneration and in affected brain regions from AD patients at different stages of the …

Regulation Of Alpha-1-Adrenoceptor-Mediated Contractions Of The Uterine Artery By Pkc, Hongying Zhang

Loma Linda University Electronic Theses, Dissertations & Projects

Pregnancy is associated with a significant decrease in uterine vascular tone and a striking increase in uterine blood flow, which ensures normal fetal development. Multiple mechanisms are involved in the adaptation of uterine artery contractility during pregnancy. Both protein kinase C (PKC) and activation of ai-adrenoceptors play important roles in the regulation of uterine artery contractility. In addition, PKC mediates the pregnancyassociated decrease in myogenic tone of the uterine artery, and interacts with ajadrenoceptors leading to modulation of ai-adrenoceptor-mediated contractions of vascular smooth muscle. Yet, whether or to what extent PKC regulates ai-adrenoceptormediated contractions of the uterine artery and their …

Repeatability Of Serial Carotid Intima Media Thickness Scanning On Individual Subjects, Judi Nightingale

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Heart disease affects millions of Americans each year. In order to improve primary prevention, early risk identification is essential. B-mode ultrasound of the common carotid artery (CCA) intima-media thickness (IMT) assesses risk of a coronary event early in the process of plaque development. Because IMT changes are so small over time, in order to determine clinically significant versus clinically insignificant changes in IMT over a 12 month time period, a protocol is needed which can detect the least significant difference (LSD) of at least 0.030 mm.

Purpose. The purpose of this study was to develop and test a well-defined …

Binge Eating, Emotion Regulation, And Cognitive Resources, Jennifer A. Tucker

Loma Linda University Electronic Theses, Dissertations & Projects

Research has shown that individuals with binge eating disorder (BED) have difficulty coping with negative emotions, although no research to date has directly investigated emotion regulation and binge eating. In the current study individuals with varying amounts of BED characteristics were measured for accuracy on a computerized task involving attention and working memory. Subsequent to the task, participants were given three self-report measures: the Eating Disorder Examination Questionnaire (EDEQ-I; Fairbum & Celio, 2004), the Positive and Negative Affect Schedule (PANAS; Watson, Clark & Tellgen, 1988), and the Emotion Regulation Questionnaire (ERQ; Gross & John, 2003). It was hypothesized that in …

The Association Between Lifestyle Factors And Inflammatory Markers, Kerry Ann Stonebrook

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Cardiovascular disease (CVD) is the leading cause of death for both men and women in the United States. While smoking, high blood pressure, and elevated cholesterol levels are established risk factors for CVD, inflammation is being evaluated as a potential independent risk factor. A key cytokine regulator of the inflammatory response, interleukin-1 (IL-1), has emerged as playing a particularly important role at the genetic level in determining the degree to which the inflammation pathway is turned on. How an individual’s genetic make-up affects inflammation, CVD risk, and response to lifestyle intervention is an area of research that is in …

The Effect Of Walnuts Compared To Fatty Fish On Plasma And Erythrocyte Fatty Acid Composition, Lymphocyte Subsets And Inflammatory Mediators, Yu-Lan Ching

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to compare the effects of walnuts vs. fatty fish on circulating inflammatory markers, on lymphocyte subsets, on plasma concentrations of eicosanoids precursor polyunsaturated fatty acid and on erythrocyte membrane fatty acid composition. Under controlled metabolic feeding conditions and randomized crossover (3x3 Latin-square) design, 27 subjects alternately consumed a control diet, a walnut diet (1.5 oz (42.5g) /day of walnuts, 6 times/week) or a fish diet (8 oz (226g) /week of salmon) for 4 weeks each. Consumption of the walnut diet (ALA 5.43 g/day) compared to the fish diet (EPA 170 mg/day and DHA 590 …

Predictability Of Cardiovascular Disease Event Rates By Common Carotid Artery Intima-Media Thickness In The Atherosclerosis Risk In Communties (Aric) Study, Mara Hollander

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Carotid artery intima media thickness (IMT) is a non-invasive reliable predictor of the extent and severity of CVD. There is difficulty acquiring all measurements for validated three-site carotid IMT. More accessible one-site common carotid artery (CCA) IMT has not yet been validated with CVD events.

Purpose: This study will evaluate the diagnostic accuracy of one-site CCA IMT compared to three-site IMT in predicting cardiovascular disease (CVD) events. Assessment of whether the association of incremental one-site CCA IMT to a CVD event is significant with and without adjustment for traditional cardiac risk factors was made.

Methodology: Data from The Atherosclerosis …

The Latino Caregiver Experience Among Dementia And Non-Dementia Caregivers : Can Community Based Care Management Improve Caregiver Health?, Catherine Oliveros

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This study provides an analysis of the Latino caregiving community in Southeast Texas and the role community based care management plays in influencing caregiver physical and emotional well-being. Design and Methods: A non-random sample of 63 Latino caregivers was interviewed by phone. Caregiver physical and emotional well-being was studied through burden, depression, perceived health status, and resourcefulness. Regression, correlation, and comparison analysis was performed with key variables. Results: Acculturation was positively correlated with care management use. In comparing dementia and non-dementia caregivers both groups had similar levels of depression and burden, however, the dementia group had significantly lower levels …

A Continued Investigation Of Craniofacial Growth In Infant Heart Transplant Recipients Receiving Cyclosporine, Gabriel Enriquez

Loma Linda University Electronic Theses, Dissertations & Projects

Since the mid 1980’s, Cyclosporine has proved to be an effective immunosuppressive drug and now has a widespread application in organ transplantation. Several studies, however, have implicated cyclosporine as adversely affecting craniofacial growth in the pediatric population. ^16,18 The purpose of this follow-up study was to continue to evaluate the possible untoward effects of long-term use of cyclosporine on craniofacial growth in a group of infant heart transplantation recipients by re-evaluating as many subjects as possible from the original study and evaluating new subjects. A pediatric group (N=13) was composed of six Caucasian subjects (4 male and 2 female, ages …