Medicine and Health Sciences Commons^™

Characterization Of Rhbmp-2 Induced Heterotopic Bone Subjected To Distraction Osteogenesis, Anne J. Yoon

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to characterize and analyze the heterotopic bone regenerate which formed following implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) and to determine by epi-illumination, x-ray photometry and histology, if there is increased and sustained osteogenic potential present with distraction osteogenesis of this heterotopic bone. While many previous studies have documented the osteogenic potential of BMP-2, no study to date has shown the results of application of force on this ectopic bone. Our study included three control rats (non-expansion) and six experimental rats (expansion). Of the control rats, #76 (a pilot study rat) had already …

Healing The Effects Of Medical Errors: A Vision Of Justice As Wholeness, Christiane Catharine Schubert

Loma Linda University Electronic Theses, Dissertations & Projects

Medical errors cannot be avoided completely even when employing the greatest care and applying the most sophisticated medical technologies. They occur when organizational, human, technical, or environmental factors lead to unintentional failures which result in recognizable physical, mental, spiritual, or social harm to patients. Until recently, the medical profession has responded with silence while patients remained uncompensated or resorted to the legal system. Professional distancing undermines transparency and patient safety while medical malpractice litigation ruptures the fragile relationships between patients and healthcare providers in whom patients trust. Philosophically, these responses draw on the framework of deontological liberalism, promoting notions of …

Family Variables As Predictors Of Adolescent Substance Abuse Treatment Outcome, Gina R. Sillo

Loma Linda University Electronic Theses, Dissertations & Projects

The current study sought to investigate the importance of family variables as they potentially predict treatment outcome for adolescents at two intensive outpatient drug treatment programs. A growing body of research has demonstrated that family dynamics serve to influence drug using behaviors and substance abuse treatment. More specifically, empirical support has suggested that the quality of family relationships is an important factor serving to influence affective treatment. The current investigation considered two primary domains of family influence: family cohesion and family conflict. Results revealed that the study variables comprising these domains were not found to be associated with adolescent treatment …

Anti-Inflammatory Effects Of Ppar-Gamma In Surgical Brain Injury (Sbi), Amy Hyong

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Brain injury can be caused by neurosurgical procedures themselves, due to direct trauma, retractor stretch, intraoperative hemorrhage and electrocautery damage. As a result of this surgical brain injury (SBI) postoperative complications such as inflammation, brain edema, and cell death can occur in the susceptible brain areas. Cerebral inflammation is a known contributor to the pathophysiology of brain injury. Following brain injury, the release of inflammatory mediators facilitates the development of BBB breakdown, cerebral edema, oxidative stress and neuronal death, resulting in further tissue damage in the brain and poor neurological outcomes. This study evaluates whether the use of a …

Orthodontic Mini-Implant Failure: Assessing The Relationship To Bone Quality Using Qcbct, Joshua Schneider

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the cortical bone thickness (mm), cortical bone density (HU), and trabecular bone density (HU) of mini-implants sites in both the maxilla and mandible using QCBCT to determine if they had any effect on mini-implant failure rate. Patient characteristics (age, gender, facial type), mini-implant characteristics (date of placement, manufacturer, length, and diameter), and the mini-implant site (region) were also evaluated. One hundred and six mini-implants in 50 consecutive patients with complete patient records, CBCT information, and T1 radiographs were included in the study. Thirty-four of the 106 mini-implants were considered "failures" resulting in …

Predictive Measures Of Cognitive Outcome In Adults Sustaining Brain Injury, Herminia De La Rosa-Trujillo

Loma Linda University Electronic Theses, Dissertations & Projects

To date, there is no consistent and accurate outcome prediction method for patients with traumatic brain injury (TBI). Commonly used clinical measures such as the Glasgow Coma Scale (GCS) and traditional radiological methods of x-rays and computed tomography (CT) scans do not always accurately predict patient functional outcome. These radiological methods are adequate in determining gross structural anatomical disturbances, however, they are unable to detect more diffuse cellular damage believed to be responsible for the functional impairments evidenced in patients sustaining TBI. Magnetic resonance imaging allows for various non-invasive sequencing techniques that have demonstrated to be a potentially valuable method …

An In-Vitro Investigation Of The Physical Properties Of Alginate Alternatives, Rishi Dinesh Patel

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the detail reproduction, gypsum compatibility and linear dimensional change of three recently introduced irreversible hydrocolloid (alginate) alternatives. The materials that were tested are Position Penta Quick® (3M ESPE™), Silgimix® (Sultan Dental) and Alginot® (Kerr™). These materials were tested in accordance with ANSI/ADA Specification No. 18 for Alginate Impression Materials and No. 19 for Dental Elastomeric Impression materials. The irreversible hydrocolloid impression material Jeltrate Plus antimicrobial® (Dentsply Caulk™) served as the control.

MATERIALS AND METHODS: The ADA specification die was used to undertake the testing of the new materials. The parameters of detail …

The Comparative Radiopacity Between Primary And Permanent Teeth, Robert C. Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This in vitro study compared the radiopacity between human primary and permanent enamel and dentin. It also compared the radiopacity between human anterior and posterior teeth.

Methods: Extracted primary and permanent teeth were used in this study. One mm enamel and one mm dentin slices were cut from each extracted tooth. Radiographs were taken of each enamel and dentin specimen 1 mm in thickness along with an aluminum step-wedge using procedures specified in International Standards Organization (ISO) 4049:2000. A densitometer was used to measure the Optical Density (OD) of the radiographs of the specimen and the accompanying aluminum step-wedge. …

The Effectiveness Of Treatment In An Inpatient And Outpatient Psychiatric Facility, Timothy Quan Tran

Loma Linda University Electronic Theses, Dissertations & Projects

The present study is aimed at examining treatment outcome in a large psychiatric facility that provides both inpatient and outpatient services to a broad range of patients. Not only will patient outcomes be assessed at a facility-wide level, but patient outcomes on the various units/programs in the facility will also be assessed and compared. It is expected that, facility wide, patients will show significant improvement on the outcome measure from admission to discharge, but that patient outcomes will differ across the various units/programs in the facility. In sum, the results of the paired-sample t-test and effect size obtained in this …

Effect Of 3-Electrode Electrical Stimulation On Current Delivery And Healing In Chronic Wounds, Hyejin Suh

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic wounds have been an enormous burden on the healthcare system due to their prevalence and the lack of efficacy of current treatment modalities. Over the years, electrical stimulation (ES) has been widely used in the treatment of wounds. Unfortunately, the effectiveness of this treatment is under scrutiny, since many studies have failed to report successive and/or consistent effects of ES on wound healing. This inconsistency may be due to the uneven current produced by the conventional 2-electrode delivery system (2-channel ES) and the reduced resting blood flow resulting from thermally cool treatment rooms. In this study, a new approach …

A Theory Of Positive Mental Health, Jason D. Rowden

Loma Linda University Electronic Theses, Dissertations & Projects

For many decades psychological research has erred on the side of looking toward pathology and has neglected to define what positive mental health functioning is on an individual level (Dahlsgaard, Peterson, & Seligman, 2005, p. 203). Without a sound theory of positive mental health, the field of psychology is left guessing as to its meaning. The importance of having a clear definition of mental health cannot be underscored enough. Without a clear understanding of mental health, the field of psychology is forced to function with varying opinions, defined by each clinician. The goal of the current thesis is to contribute …

Study Of Executive Functioning Training In Adolescents Diagnosed With Autism, Jessica Postil

Loma Linda University Electronic Theses, Dissertations & Projects

This study investigated the effectiveness of a manualized executive functioning training program used with adolescents diagnosed with autism. Three male adolescents were trained on executive function activities using a combination of Applied Behavioral Analysis and executive functioning activities. Training programs were administered individually, lasting for 2 hours per day for 20 days. Participants were tested 1 month before training, 1 week before treatment, immediately after training and at a one-month follow-up. Significant improvements were seen in performance on executive functioning tasks that required motor speed, verbal fluency, monitoring, predicting, planning and organization skills. Significant changes in the participant’s adaptive behavior …

Recognizing A Dysfunctional Swallowing Pattern Using Surface Electromyography (Semg), Michelle F. Couto

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The purpose of this study was to determine if a surface electromyography (sEMG) assessment of swallowing is better at identifying Oral Muscular Dysfunction (OMD) than a clinical evaluation (observation & digital palpation) of swallowing. The assessment was conducted on children ages 9 to 17, who were patients at the Orthodontic Department at Loma Linda University, School of Dentistry. Additionally, the prevalence of a “perceived” swallowing dysfunction was assessed.

Methods: This study included 39 randomly selected subjects from the orthodontic patients at Loma Linda University. Each subject’s “dry” swallow was evaluated using two separate methods: (a) sEMG and (b) digital …

Arginine Vasopressin And Male Attachment: A Marital And Family Therapy Perspective, Calvin James Thomsen

Loma Linda University Electronic Theses, Dissertations & Projects

Social neuroscience offers a promising way to understand some dimensions of adult attachment. Arginine vasopressin (AVP) is a neuropeptide with significant implications for human social behavior and it provides an important testing ground to explore links between social/interpersonal neurobiology and attachment. It has a distinctive impact on the social/relational behavior of certain male animals, most notably prairie voles. It fosters monogamy, creates attachment to both mate and offspring, and increases affiliation and a desire for physical proximity with other animals of the species. There has been much speculation that it might play a similar role with human males. This study …

Breast Cancer Screening Disparities In Japanese-American Women, Theodora Stratis

Loma Linda University Electronic Theses, Dissertations & Projects

Cancer screening disparities in ethnic minority women have received much research attention in the last several years due to a marked increase in ethnic minority cancer incidence and poor survival rates (Miller, Kollnel, Bernstein, Young Swanson, West et ah, 1996). Breast cancer is the leading cause of death for Asian American women (Asian American Network for Cancer Awareness, Research & Training, 2002) and, although their incidence and mortality rates are lower than Caucasian women, these rates continue to increase every year. This increasing mortality rate is likely due to the underutilization of breast cancer screening by Asian American women. Asian …

The Association Of Maternal Intention To Breastfeed, Early Skin-To-Skin Mother/Infant Contact, And Exclusive Breastfeeding During The Maternity Hospital Stay, Leslie Mary Bramson

Loma Linda University Electronic Theses, Dissertations & Projects

Breastfeeding is the optimal method to nourish and nurture an infant. Exclusive breastfeeding rates in the United States have reached the goal of Healthy People 2010 that 75% of mother's breastfeed in the immediate postpartum period. Yet, less than 35% of San Bernardino county mothers and 47.7% of Riverside county mothers are exclusively breastfeeding during their maternity hospital stays, with as many as 50% of the infants being weaned from the breast in the first 14 days of life.

This prospective study examined archived data collected by Perinatal Services Network (PSN) of Loma Linda University Medical Center/Children's Hospital for the …

Knowledge, Perceptions, Beliefs And Behaviors Related To The Prevention Of Hypertension Among Black Seventh-Day Adventists Living In London, Maxine A. Newell

Loma Linda University Electronic Theses, Dissertations & Projects

This study was a cross-sectional survey of the hypertension (HTN) knowledge and risk behaviors of Black Seventh-day Adventists (SDA) in London. Recruitment took take place in 17 predominantly Black SDA churches in London. A questionnaire assessed knowledge and lay-beliefs about HTN and perceptions towards HTN using the health belief model (HBM) constructs of susceptibility, severity, benefits, barriers, and self-efficacy. Cohen’s Perceived Stress Scale was incorporated into the questionnaire. Blood pressure, height, weight and waist circumference were and current lifestyles practices were evaluated for the presence of HTN risk factors.

Of the 312 volunteers, ages 25 to 79, 55% were born …

Psychosocial Support, Newborn Readmissions, And Postpartum Follow-Up, Dora Barilla

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Women and their infants are being discharged as soon as 24 hours after giving birth without proper follow-up care. The Maternity Department at San Antonio Community Hospital established the Family Care Center (HBFCC) in November 2000 in response to a higher than expected newborn readmission rate, shorter maternity hospitalizations, and a lack of postpartum follow-up. A comprehensive program was offered to support new families in the form of developmental assessment and intervention, breastfeeding, infant and toddler nutrition, health promotion and education, and referrals to appropriate agencies when indicated. In 2004, due to inadequate funding, the hospital reduced the intervention …

Response Of Endothelial Cells To Stressors: The Impact Of Aging And Diabetes, Katie Mclellan

Loma Linda University Electronic Theses, Dissertations & Projects

Preliminary research indicates there is some impairment of the endothelial cells to respond to single stressors such as local heat, shear stress, and global heat in older people and people who have diabetes. The response of the skin blood flow to local heat is an indicator of the endothelial cells ability to cope with stress. In addition, factors such as thicker subcutaneous fat and skin moisture may impair the skin’s ability to dissipate heat. For older people and people with diabetes, this endothelial dysfunction may cause an even more diminished response to multiple stressors. However, no studies have examined the …

Values, Ethnicity, And Ses : The Case Of Latino And Anglo American Women, Claudia Venessa Argueta

Loma Linda University Electronic Theses, Dissertations & Projects

Past research on values has typically employed a quantitative and top-down approach in determining the universality of values across gender, religion and nation categories (Schwartz & Huismans, 1995; Schwartz & Bardi, 2001). However, studies have often failed to identify specific values that are related to particular ethnic and socioeconomic communities within a culturally diverse society (Lee, Whitehead & Balchin, 2000; McCulloguh, Wilson, Teasdale, Kolpakch, & Skelly, 1993). The aim of this study was to use a bottom up, qualitative approach to identify core values among Latino and Anglo women in Southern California. The research was guided by a model for …

Child Sexual Trauma: Testing The Robustness Of Browne & Finkelhor's Theory, Jose Mauricio Ramirez

Loma Linda University Electronic Theses, Dissertations & Projects

Trauma has received great attention in the last three decades and a major societal issue today is child sexual abuse. Twelve percent of victims of maltreatment every year are victims of child sexual abuse (CSA). Several studies have suggested that the prevalence of CSA in women is in the range of 6% to 62% depending on how the data was collected (e.g., interviews, surveys) and the nature of the population sampled (e.g., general population, clinical population). Because of CSA, victims are impacted by the experience and encounter a change in the way they perceive the world on both the way …

A Geospatial Approach For New Perspectives On Satisfaction With Health Services In Malawi, Gideon Mazinga

Loma Linda University Electronic Theses, Dissertations & Projects

This dissertation explored the spatial pattern of user satisfaction with health services and factors, including policies that potentially explain the variation in the district-level of user satisfaction with health services. Nationwide secondary data was extracted from the 2002 Core Social Welfare Indicators Survey and the National Health Services Statistics databases obtained from National Statistics of Malawi. The National Health Facilities inventory obtained from the Malawi diffusion project was also geocoded to display the distribution of health care facilities in the country. Spatial autocorrelation and regression modeling techniques were applied on the national representative data set.

The spatial autocorrelation test revealed …

Comparison Of Microleakage In Three Sealant Placement Protocols Vs. The Enamel Loc System, Audrey T. Sheu

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To evaluate sealant microleakage using four different application techniques.

METHODS: The four application techniques evaluated were acid etch only, Adper L-Pop bonding, Optibond bonding, and Enamel Loc One-Step Sealant. Sixty-four extracted third molar teeth were assigned on one of four application techniques (n=16) and Clinpro sealants applied according to the manufacturer's instructions. The teeth were thermocycled for 500 cycles, dyed, and embedded in resin. The samples were then sectioned and evaluated for microleakage on the buccal and lingual surfaces. Statistical methods employed to analyze the data were the Kruskal-Willis rank test and the Mann-Whitney U test.

RESULTS: No significant …

Immediate Provionalization Of Single Threaded Oxidized Implants On Maxillary Premolars Healed Sites: One-Year Study, Kiyotaka Umezu

Loma Linda University Electronic Theses, Dissertations & Projects

Osseointegrated endosseous implants have been widely used and become a predictable treatment option for completely and partially edentulous patients. The viability and predictability of this treatment modality have been supported with the high success rates in numerous studies. Clinical guideline requires a healing period of 3 to 6 months without functional loading to achieve osseointegration with machine surface implants. Therefore, numerous studies on immediately loaded implants have been conducted in an attempt to minimize or eliminate this healing period. The purpose of this study was to evaluate the success rate of the immediately provisionalized oxidized-surface implants in healed sites supporting …

Immediate Provisionalization Of Single 3.0 Mm Diameter Implant In Maxillary And Mandibular Anterior Region, Kotaro Oyama

Loma Linda University Electronic Theses, Dissertations & Projects

Immediate provisionalization of single implants with standard (3.75 - 4.5 mm) and wide diameter (> 4.5 mm) has been well documented. When the space is limited, small diameter implants (3.0 mm) must be used. Although high success rates have been reported, they were limited to healed site and were placed as staged procedures. The purpose of this prospective study was to evaluate the success rate and peri-implant tissue response of small diameter (3.0 mm) implants undergoing immediate provisionalization in the esthetic area.

Eleven patients who had missing maxillary lateral incisor(s) and/or mandibular incisor(s) participated in this study. Thirteen 3.0 mm …

Oxidative Stress-Mediated Anticancer Activity Of Novel Ahr Modulators Af & 5f203, Lancelot S. Mclean

Loma Linda University Electronic Theses, Dissertations & Projects

Estrogen receptor positive (ER+) breast cancer tends to respond to anti-estrogen agents such as Tamoxifen. Approximately 40% of ER+ breast cancer is resistant to these agents and those that initially respond often acquire resistance. Estrogen receptor negative (ER-) breast cancer remains largely unresponsive to these agents. It is therefore vital to discover drugs that are potent in both forms of breast cancer. Aminoflavone, (5-amino-2, 3-fluorophenyl)-6,8-difluoro-7-methyl-4H-l-benzopyran-4-one; AF; NSC 686288) and 5F203, (2-[-Amino-3-methy phenyl]-5-flurobenzothiazole) are novel anticancer candidate agents that display potent in vitro and in vivo anti-proliferative activity against select human tumor cells with a unique anticancer activity profile in the …

Predicting Long-Term Memory In Adult Brain Injury Patients Using Mr Spectroscopy, Herminia De La Rosa-Trujillo

Loma Linda University Electronic Theses, Dissertations & Projects

Accurate outcome prediction has proven to be somewhat elusive for patients with traumatic brain injury (TBI). The difficulty is due to the sometimes inaccurate methods of prediction currently available. Despite the advances seen in radiological technology, the traditional methods of x-rays, CT scans and MRIs are not always accurately able to predict patient functional outcome. These radiological methods are adequate in determining gross structural anatomical disturbances, however, they unable to detect more diffuse cellular damage believed to be responsible for the functional impairments evidenced in patients sustaining TBI. Magnetic Resonance Spectroscopy (MRS) is an imaging technique which measures brain metabolites …

Factors That Affect Performance On Executive Functioning After Coronary Artery Bypass Grafting, Sapna Mahesh Patel

Loma Linda University Electronic Theses, Dissertations & Projects

Research suggests that individuals who undergo coronary artery bypass grafting (CABG) experience declines in neuropsychological functioning post-operatively. This decline has been observed in up to 80% of patients early after surgery, and in up to 30% of patients after six months. Many studies have examined the potential effects of CABG on neuropsychological functioning in general, and numerous studies have found that executive functions are impaired in particular. However, none have examined what factors contribute to observed executive dysfunction after CABG. This study investigated the role of memory functions on executive functions in a selected sample of patients undergoing CABG. This …

Hiv Risk Among Nursing Students In Rwanda : Self-Efficacy, Knowledge And Attitudes, Jacqueline Wosinski

Loma Linda University Electronic Theses, Dissertations & Projects

Acquired immune deficiency syndrome (AIDS) is the leading cause of death in sub-Saharan Africa. With a prevalence rate of 3.1% in 2006, Rwanda is one of the hardest hit countries. Nurses are often the leading health professionals in rural communities and at the forefront of the fight against the HIV pandemic. Little has been written on how nurses are prepared to intervene successfully along the continuum of HIV prevention and care. A mixed-methods sequential exploratory approach was used to explore this question.

In the first phase, cognitive, socio-psychological, and environmental factors of nursing education in Rwanda in regard to HIV …

Partner Communication And Factors Associated With The Decision To Obtain An Hiv Test Among Chinese/Chinese American Community College Students In Northern California, Sang Leng Trieu

Loma Linda University Electronic Theses, Dissertations & Projects

HIV testing and counseling is considered the cornerstone of a comprehensive approach to HIV prevention and education. Little is known, however, about HIV prevention, including HIV testing rates for Asian Pacific Islander (API) women, because data for this ethnic group is aggregated, thus limiting specific data for Chinese/Chinese American population or other API subgroups. This dissertation research examined factors associated with the decision to obtain an HIV test among Chinese/Chinese American community college women and explored the association among relationship status, partnership communication, and discussions of HIV testing.

Using constructs of the health belief model, an online and paper-pencil, crosssectional …