Medicine and Health Sciences Commons^™

Effectiveness Of Chronic Obstructive Pulmonary Disease (Copd) Management Program At The University Of Louisville., Malhar Anantbhai Jhaveri

Electronic Theses and Dissertations

Background: Chronic obstructive pulmonary disease (COPD) is a progressive disease of the respiratory system characterized by airflow limitation that is not completely reversible and is associated with systemic effects especially of the cardiovascular system. COPD is frequently complicated by acute exacerbations that contribute to physical impairment and increased health care use. As COPD is a chronic lung disease with significant systemic manifestations, it is important to have chronic disease management programs specifically targeting individuals with COPD designed to improve their overall quality of life, reduce the burden of disease and decrease the impact of COPD on daily life. Chronic disease …

Clinical Efficacy Of Cross-Sectional Imaging Compared With Panoramic Imaging And Virtual 3d Models For The Assessment Of Dental Implant Placement., Moiz Ahmad Khan 1987-

Electronic Theses and Dissertations

Introduction: This study compared the clinical efficacy of panoramic imaging and Cone Beam Computed Tomography (CBCT) in the optimal placement of virtual dental implants in the posterior edentulous bounded regions of the jaws. Material and methods: From a retrospective audit of patient records, fifty-two subjects were recruited with sixty-one dental implant sites in the maxilla and mandible. Physical measurements of the residual alveolar ridge were performed and consensus decisions of optimal implant length and bone graft necessity were obtained using reformatted panoramic alone (RP) or cross-sectional imaging (XS). Results: Horizontal restorative space measurements greater for RP (p=0.001). Shorter implants were …

Assessment Of Red Blood Cell Membrane Fatty Acid Composition In Relation To Dietary Intake In Patients Undergoing Cardiac Catheterization, Nicole S. Litwin

Electronic Theses and Dissertations

Red blood cells (RBC) have been shown to mediate plaque development seen in coronary artery disease (CAD). This study determined whether differences in RBC fatty acid (FA) composition were related to CAD risk. FAs were extracted from RBCs of 38 individuals who have undergone cardiac catheterization, 9 of whom had obstructive CAD, and analyzed via gas chromatography. Ferric reducing ability of plasma (FRAP) assay was used to determine oxidative stress. Food frequency questionnaires were used to correlate RBC omega-3 FA to daily intake of omega-3 FA. No correlation was found between RBC content and intake of omega-3 FA. FRAP values …

Extracellular Ubiquitin: Role In Cardiac Myocyte Apoptosis And Myocardial Remodeling, Christopher Ray Daniels

Electronic Theses and Dissertations

Activation of sympathetic nervous system is a key component of myocardial remodeling that generally occurs following ischemia/reperfusion (I/R) injury and myocardial infarction. It induces cardiac myocyte apoptosis and myocardial fibrosis, leading to myocardial dysfunction. Intracellular ubiquitin (UB) regulates protein turnover by the UB-proteosome pathway. The biological functions of extracellular UB in the heart remain largely unexplored. Previously, our lab has shown that β-adrenergic receptor (β-AR) stimulation increases extracellular UB levels, and extracellular UB inhibits β-AR-stimulated apoptosis in adult rat ventricular myocytes (ARVMs). This study explores the role of extracellular UB in myocyte apoptosis, fibroblast phenotype and function, and myocardial remodeling …

Novel Therapeutic Approaches For Ischemic Heart And Brain Injury: Modulation Of Toll-Like Receptor-Mediated Signaling Pathways And Pi3k/Akt Signaling, Chen Lu

Electronic Theses and Dissertations

Innate immune and inflammatory responses contribute to myocardial and cerebral ischemia/reperfusion (I/R) injury. Toll-like receptors (TLRs) play a critical role in the induction of innate immune and inflammatory responses via activation of nuclear factor kappa B (NF-κB). We have shown that activation of NF-κB contributes to myocardial and cerebral I/R injury. Indeed, inhibition of TLR4-mediated NF-κB activation significantly decreased myocardial and cerebral I/R injury via activation of PI3K/Akt signaling. PI3K/Akt signaling is an important pathway in regulating cellular survival and inflammatory responses. Therefore, an important question is how to differentially modulate PI3K/Akt signaling and TLR/NF-κB-mediated signaling pathway during I/R injury? …

Vitamin D Status Of College Students: Implications For Health Leaders, Eileen M. Cress

Electronic Theses and Dissertations

Vitamin D deficiency is considered to be a pandemic with implications for compromised bone health and other chronic diseases. Few studies have examined vitamin D status in college-aged individuals where prevention of future health consequences is still possible. Serum vitamin D 25(OH)D status and vitamin D intake were examined in 98 college students ages 18-29 years during winter. BMI was classified as < 25and 25 or greater. Race was categorized as Caucasian or other. Overall, 69.5% had suboptimal serum vitamin D levels, <30ng/mL. Only 8 students (8.2%) met the EAR (400 IU) per day for vitamin D intake. t tests were used to determine if there were significant differences in serum vitamin D level and dietary intake based on gender, race and BMI. Significant differences were found in serum vitamin D level when compared by gender and race. Females tended to have a higher serum vitamin D level than males. Those representing minorities had lower serum vitamin D levels than Caucasians; One hundred percent of the minority students had suboptimal serum vitamin D levels. Based on these findings, dietitians should increase efforts to target college-aged individuals in educational programming related to factors affecting vitamin D synthesis, vitamin D intake, and health consequences of suboptimal vitamin D status, particularly in winter. Consideration should be given to vitamin D fortification of foods that meet the preferences of today’s consumer.

Social Support And Affectionate Communication In Animal-Assisted Interventions: Toward A Typology And Rating Scheme Of Handler/Dog Messages, Amy Mccullough

Electronic Theses and Dissertations

Animal-assisted interventions (AAIs) are a treatment modality that incorporates a trained animal into a person's healing and learning process in order to benefit the person physically, emotionally and/or socially (Delta Society, 1996). From an interactional perspective, two mechanisms that may contribute to these health benefits are social support and affection exchange. Although there is growing evidence of the health and well-being benefits of AAIs, there remains a need for scientific research to understand more precisely the communicative and behavioral components that constitute a therapeutic intervention involving an animal (Kazdin, 2010). Additionally, there is a need to develop a means of …

Substance Use And Drug Distribution At The Individual Level: A Grounded Theory Approach, Evan Thomas Stanforth

Electronic Theses and Dissertations

Substance use regularly occurs among individuals that distribute drugs and there is a limited amount of research that has examined both use and distribution. A grounded theory approach was used to develop a framework for analyzing relationships between use and distribution behaviors. 15 participants (five female, 10 male) that had experience selling drugs and using drugs were recruited from a residential substance abuse treatment center. Each participant was interviewed for one hour with an interview protocol aligning with the stage of analysis. A model was developed to explain Involvement and Integration in a Drug World with the codes Substance Use, …

Identification Of A Treatment-Resistant, Ketamine-Sensitive Genetic Line In The Chick Anxiety-Depression Model, Stephen Walter White

Electronic Theses and Dissertations

Approximately 60% of Major Depressive Disorder (MDD) patients do not respond to FDA-approved antidepressants. Introducing effective pharmacotherapies for this treatment-resistant population is hindered by the lack of pre-clinical screening assays that accurately model the clinical features of TRD. The purpose of this research was to screen representatives of different classes FDA-approved antidepressants and one novel antidepressant in two genetic lines of domestic fowl chicks that have previously been identified as stress-vulnerable and stress-resilient in the chick anxiety depression model. Separate groups of socially raised Black Australorp (stress-vulnerable) and Production Red (stress-resilient) chicks were administered the tricyclic antidepressant imipramine (0-20 mg/kg), …

Home Care Quality Effects Of Remote Monitoring, Cynthia Williams

Electronic Theses and Dissertations

Despite concerted efforts to decrease costs and increase public health, the embattled U.S. health care system continues to struggle to alleviate these widespread issues. Because the problem of hospital utilizations among patients with heart failure is posited to increase as the population ages, innovative methodologies need to be explored to mitigate adverse events. Remote monitoring harnesses the strength of advanced information and communication technology to affect positive changes in health care quality and cost. By reaching across geographical boundaries, remote monitoring may support increased access to less costly services and improve the quality of home health care. The purpose of …

Zinc Sulfide: Manganese Doped Quantum Rods For Detection Of Metal Ions And A Business Model For Future Sales, Andrew Teblum

Electronic Theses and Dissertations

Hexavalent chromium is an extremely carcinogenic chemical that has been widely produced in the United States. This has led to major waste contamination and pollution throughout the country. According to the Environmental Working Group Hexavalent chromium has been found in 89% of city tap water. Most people believe they are safe using regular home filter systems however that is not true. A more expensive ion exchange water treatment unit is required. Therefore to protect yourselves from this carcinogenic metal a reliable test is required. In this study we have developed a Zinc Sulfide Manganese doped Quantum Rod technology to detect …

The Cross Education Of Neuromuscular Economy, Kyle Beyer

Electronic Theses and Dissertations

Cross education is the phenomenon by which the untrained limb will experience a gain in strength following a unilateral resistance training program. However, little is known as to the underlying adaptation occurring in the untrained limb. Purpose: To examine the effect of dynamic unilateral resistance training on the strength and neuromuscular adaptations of both the trained and untrained legs. Methods: Eight previously untrained males (22.38±2.92 y, 1.73±0.08 m, 75.26±14.53 kg) completed a four-week unilateral resistance training program, while another eight untrained males (24.00±4.57 y, 1.84±0.05 m, 94.21±16.14 kg) served as controls. Isometric leg extension strength, leg press 1 repetition maximum …

Solubility Enhancement And Precipitation Inhibition Of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology, Jiannan Lu

Electronic Theses and Dissertations

Soluplus® (SOL), a graft amorphous copolymer, composed of polyethylene glycol, vinyl acetate and vinylcaprolactam in a ratio of 13: 30: 57, was utilized to prepare solid dispersions containing felodipine (FEL) or ketoconazole (KTZ) using hot-melt extrusion technology. The melting point depression approach was utilized to determine the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when compared to ketoconazole (14% vs 4.3% w/w) at room temperature (298K). Moreover, the solubility parameters of FEL, KTZ and SOL were calculated as 21.76, 26.51 and 21.64, respectively.

Polarized light microscopy, Fourier transform infrared spectroscopy (FT-IR), …

Exploring Jungian Archetypes As Potential Predictors Of Infidelity In Committed Relationships, Kattrina Miller Roach

Electronic Theses and Dissertations

No abstract provided.

Transgenerational Transmission Of Trauma In Second Generation Latino Children And Adolescents, Ricardo Phipps

Electronic Theses and Dissertations

This study explored the impact that immigration-related trauma has upon families, particularly second-generation immigrant children in the Latino-American community in the United States, and the possibility that second-generation immigrant Latinos are vulnerable to transgenerational trauma. Transgenerational trauma involves the exhibition of posttraumatic stress disorder (PTSD) symptoms in subsequent generations in families with histories of trauma exposure. Multiple linear regression was conducted to explore the existence of a correlation between PTSD and depression in second-generation Latino immigrant children and adolescents with a myriad of potentially predicting factors. Enhanced understanding of how trauma can affect the children of traumatized immigrants will add …

The Effects Of Carbonated Soft Drinks On Bone Mineral Density In College Age Women, Tina Irene Bankston

Electronic Theses and Dissertations

Osteoporosis is a fast growing, worldwide public health problem. Also called, 'the silent disease' or 'fragile bone disease', osteoporosis results from low bone mass (Gammage & Klentrou, 2011; NOF, 2013; Swann, 2012). Currently, 44 million Americans have osteoporosis; 80% of which are women (NOF, 2011). Few studies, most implemented in other countries, have been conducted examining the consumption of carbonated soft drinks (CSD) as a risk factor for low bone mineral density (BMD) (Ogur et al., 2007; Hostmark et al., 2011; McGartland et al., 2003). The global consumption of CSDs increased by four percent during 2009 to 2010. Within the …

Effect Of Incorporating The Fitbit Fitness Tracking Technology Into A Prescribed Exercise Intervention Program To Improve Long-Term Function In Obese Individuals One Year Following Total Knee Arthroplasty., Webb A. Smith

Electronic Theses and Dissertations

No abstract provided.

Development Of A Physical Activity Intervention Targeted At Middle-Aged Males: A Mixed Methods Research Study, Sheryl L. Chatfield

Electronic Theses and Dissertations

No abstract provided.

Cardiovascular Disease Knowledge, Awareness, Perceived Risk, And Hormonal Contraceptive Use Among Female College Students, Amanda Kathryn Hutcheson

Electronic Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death for men and women of most racial and ethnic groups in the United States (Centers for Disease Control and Prevention, 2012). Over the past 20 years, women have experienced greater levels of CVD mortality compared to men, and specific risk factors for CVD have been identified that are unique to women, including the use of hormonal contraceptives (Corrao et al., 1990; roger et al., 2011). However, previous research has not addressed knowledge of CVD among college-aged hormonal contraceptive users. Therefore, this cross-sectional study assessed knowledge, awareness, and perceived risk of CVD …

Determining Physician And Patient Characteristics That Predict The Use Of Atypical Antipsychotics In Children With Mental Health Disorders, Sujith Ramachandran

Electronic Theses and Dissertations

No abstract provided.

Solubility Enhancement Via Melt Extrusion: Drug-Polymer Solubility, Physicochemical Characterization And Quality By Design, Ketaki Patwardhan

Electronic Theses and Dissertations

Many new drugs developed face oral delivery challenges and absorption due to poor biopharmaceutical properties. Formation of solid dispersions is a very widely applied technique for solubility enhancement of water insoluble drugs. In order to form stable solid dispersions it is important to select appropriate excipients that will maintain the drug in its amorphous form for an extended period of time. Selection of appropriate excipients is critical during the development of stable amorphous solid dispersions. The solubility parameter concept has been explored for theoretically identifying the excipients that will be suitable based on the structure of the active. In this …

Comprehension Of Science Text By African American Fifth And Sixth Grade Students: The Effects Of A Metalinguistic Approach, Karen Davis

Electronic Theses and Dissertations

Scientific literacy has been at the forefront of science education reform for the past 20 years, particularly for students from culturally and linguistically diverse (CLD) backgrounds (Lee et. al., 2005; Pearson, Moje & Greenleaf, 2010). The ability to extract meaning from text is an important skill. Yet many students struggle with effectively comprehending what they read, particularly in content areas of science, math and history. According to the National Assessment Educational Progress (NAEP, 2013) report, adolescents are not acquiring advanced literacy skills needed to succeed in the workplace and academic setting. Literacy experts have called for the use of disciplinary …

Host And Bacterial Determinants Of Staphylococcus Aureus Nasal Colonization In Humans, Gowrishankar Muthukrishnan

Electronic Theses and Dissertations

Staphylococcus aureus (SA), an opportunistic pathogen colonizing the anterior nares in approximately 30% of the human population, causes severe hospital-associated and community-acquired infections. SA nasal carriage plays a critical role in the pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be effective in reducing endogenous infections. To understand SA nasal colonization and its relation with consequent disease, assessment of nasal carriage dynamics among a diverse population and determining factors responsible for SA nasal carriage have become major imperatives. Here, we report on an extensive longitudinal monitoring of SA nasal carriage in 109 healthy individuals over …

Endocrine And Contralateral Muscle Responses To Short-Term Unilateral Resistance Training, Carleigh Boone

Electronic Theses and Dissertations

PURPOSE: The purpose of this study was to examine the effects of short-term lower body unilateral resistance training on hormonal, muscle morphological, and performance measures in young men. METHODS: Seventeen healthy, untrained young men (Age: 22.8 ± 3.7 y; BMI: 26.5 ± 4.9 kg/m2) were randomly assigned to one of two groups (UT: 22.9 ± 4.6 y, 25.3 ± 4.2 kg/m2; CON: 24.0 ± 4.6 y, 27.7 ± 5.1 kg/m2). Resistance training consisted of 4 weeks of unilateral lower body and bilateral upper body exercises on 3 days per week. Each training session entailed unilateral countermovement jumps (3 × 8), …

Development Of The Taiwanese Mandarin Main Concept Analysis And Linguistic Communication Measure: Normative And Preliminary Aphasic Data, Chun-Chih Yeh

Electronic Theses and Dissertations

Aphasia is a language disorder resulting from damage to brain areas that control language expression and reception. Clinically, the narrative production of Persons with Aphasia (PWA) provides valuable information for diagnosis of aphasia. There are several types of assessment procedures for analysis of aphasic's narrative production. One of them is to use quantification systems, such as the Cantonese Linguistic Communication Measure (CLCM; Kong & Law, 2004) or the Main Concept Analysis (MCA; Kong, 2009), for objective quantification of aphasic's discourse. The purposes of this study are (1) to translate the MCA and CLCM to a Taiwanese Mandarin Main Concept Analysis …

Acoustic Analysis Of Prolonged Vowels In Adolescents And Young Adults With Friedreich's Ataxia, Kaylea Hardin

Electronic Theses and Dissertations

This study employed spectral analyses for acoustic measures of sustained vowel productions from a group of 20 adolescents and young adults with Friedreich's Ataxia (FA) and compared findings with a group of 20 age-equivalent and gender-matched normal control participants. State-of-the art spectral analyses from the Analysis of Dysphonia in Speech and Voice (ADSV) program, developed for various voice disorders from Kay Elemetrics, were applied to initial 2 second sustained vowel segments of the vowels /a/, /i/, and /o/. Spectral analyses included averages and standard deviations of Cepstral Peak Prominence (CPP), Cepstral Peak Prominence Standard Deviation (CPP SD), Low/High Spectral Ratio …

The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner

Electronic Theses and Dissertations

Competition often requires teams that reside at sea level to compete against opponents whose residence is at a moderate altitude. This may pose a potential competitive disadvantage considering that moderate altitude may cause decrements in VO2max, distance covered, and time to exhaustion in endurance athletes. The purpose of this study was to examine the effect of altitude on game performance measures. Six NCAA Division I female soccer players (20.33 ± 1.21 y; 168 ± 6.45 cm; 62.5 ± 6.03 kg) were retrospectively examined. Comparisons were made between two competitions that were played at sea level (SL) within two weeks of …

Certified Personal Trainers And Physicians: An Evaluation Of Consumer Preference, Influence, And Decision Making On Intent To Use A Weight-Loss Medication, Linda Lemgruber Lobb

Electronic Theses and Dissertations

In health-related behavioral decision-making, the Theory of Planned Behavior (TPB) posits that attitudes toward a behavior are the function of three metrics: beliefs and strengths of beliefs toward the behavior, subjective norms around the behavior and locus of control for the individual (Ajzen, 1988). The purpose of this research was to identify the extent to which consumers would accept the recommendation of taking weight-loss medications, based on the source of the recommendation. Research shows that the source of knowledge for information plays a significant role in health-related decision-making of consumers (Pornpitakpan, 2004). In comparison to traditional weight-loss methods such as …

Pharmacists' Preparedness For Acute Medical Emergencies, James W. Parrett

Electronic Theses and Dissertations

Purpose/Objectives: This project studied how prepared community pharmacists are to respond to acute medical emergencies, as well as their perceived efficacy in addressing these situations. Specifically, it considered what training pharmacists have for responding to medical emergencies, what emergency medical equipment pharmacies have on-hand, the frequency that medical emergencies occur within pharmacies, and the types of emergencies encountered. It also measured self and collective efficacy of pharmacists in responding to medical emergencies within their pharmacy to determine if differences in self-efficacy or collective efficacy exist. Methods: This study utilized a cross-sectional, non-experimental, descriptive design via a self-administered, Internet-based survey distributed …

Customer Tolerance In Community Pharmacy, Philip Everett Schwab

Electronic Theses and Dissertations

Customers can have an existing relationship with a service provider where they are not satisfied with the services they receive, yet they continue to patronize the service provider. Why does this happen? Why do these customers remain as patrons of service providers that do not meet expectations and that leave these customers with low satisfaction. This dissertation presents the concept of tolerance to explain the retention of customers who are not satisfied with a service provider. Specifically, this dissertation examined the concept of customer tolerance in community pharmacy. Tolerance is an important concept for consideration because regardless of good intentions …