Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Pharmacy and Pharmaceutical Sciences (177)
- Public Health (24)
- Public Health Education and Promotion (12)
- Mental and Social Health (8)
- Psychiatric and Mental Health (8)
-
- Medical Sciences (6)
- Neurosciences (6)
- Communication Sciences and Disorders (3)
- Education (3)
- Higher Education (3)
- Other Pharmacy and Pharmaceutical Sciences (3)
- Physical Therapy (3)
- Rehabilitation and Therapy (3)
- Social and Behavioral Sciences (3)
- Behavior and Behavior Mechanisms (2)
- Epidemiology (2)
- Experimental Analysis of Behavior (2)
- Health and Medical Administration (2)
- Pharmacy Administration, Policy and Regulation (2)
- Psychiatry and Psychology (2)
- Psychology (2)
- Life Sciences (1)
- Medicinal and Pharmaceutical Chemistry (1)
- Nanotechnology (1)
- Pharmaceutics and Drug Design (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Speech and Hearing Science (1)
- Keyword
-
- Hot melt extrusion (10)
- Pharmaceutical sciences (7)
- Exercise (6)
- Hot Melt Extrusion (6)
- Pharmacokinetics (5)
-
- Virtual Screening (5)
- Bioavailability (4)
- Depression (4)
- Hot-Melt Extrusion (4)
- Malaria (4)
- Obesity (4)
- Ocular (4)
- 3D printing (3)
- Attitudes (3)
- College Students (3)
- Fused deposition modeling (3)
- Glaucoma (3)
- Higher education (3)
- In situ gel (3)
- Medicinal Chemistry (3)
- Parkinson's disease (3)
- Physical Activity (3)
- Physical therapy (3)
- Polymer (3)
- Quality by Design (3)
- Synthesis (3)
- Tetrahydrocannabinol (3)
- African Americans (2)
- Anxiety (2)
- Artemisinin (2)
- Publication Year
Articles 1 - 30 of 246
Full-Text Articles in Medicine and Health Sciences
Immune-Related Adverse Events Of Immune Checkpoint Inhibitors: Incidence, Risk Factors, Clinical Outcomes, And Economic Burden In Older Adults With Non-Small Cell Lung Cancer, Yiran Rong
Electronic Theses and Dissertations
To fill the gap in existing literature related to immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), this dissertation focused on: 1) assessing the incidence, spectrum and risk factors for the development of irAEs; 2) assessing the clinical impact of irAE occurrence on survival and treatment discontinuation; 3) analyzing and estimating the incremental economic burden of irAEs among an older population in the United States (US). A retrospective cohort study was conducted using the SEER-Medicare 2020 linkage database in order to evaluate the three study objectives. The dissertation included 8,175 patients diagnosed …
Prevalence Of Hearing Loss In College Students In The United States: A Meta-Analysis, Ashley Barton
Prevalence Of Hearing Loss In College Students In The United States: A Meta-Analysis, Ashley Barton
Electronic Theses and Dissertations
Purpose: Hearing loss among college students, specifically noise-induced hearing loss (NIHL), appears to be increasing. This may be particularly challenging for this population as college students are required to listen to lectures in classrooms that may have sub-optimal listening environments. Therefore, the purpose of the current study was (1) to examine the prevalence of hearing loss in college students and (2) to emphasize the importance of detecting hearing loss at 6,000 Hz.Method: A meta-analysis was conducted using the PRISMA model. The literature search yielded 8 studies (1,950 subjects) that tested hearing loss using an audiogram and Distortion Product Otoacoustic Emissions …
Nmr-Based Characterization Of A Glucan Isolated From Ganoderma Lucidum, Alysia Gonzales
Nmr-Based Characterization Of A Glucan Isolated From Ganoderma Lucidum, Alysia Gonzales
Electronic Theses and Dissertations
Ganoderma lucidum is a polypore fungus commonly known as Lingzhi, Youngji or Reishi mushroom in East Asia. It is frequently marketed as an herbal supplement and often utilized as traditional Chinese medicine. Our research comprises the structural investigation of the principal polysaccharide from this fungus. After proper purification, the fungal glucan was subjected to multiple experiments of NMR spectroscopy, including 1D 1H and 13C, 2D; 1H-1H COSY, 1H-1H TOCSY, 1H-1H NOESY, 1H-13C HSQC, 1H-1H Phase Sensitive-TOCSY, and 1H-13C TOCSY-HSQC NMR spectra. Data has confirmed that this fungal polysaccharide contains residues of glucose (91.31%) as major, galactose (4.99%), and mannose (3.69%) …
Influence Of Rage Signaling On Cellular Communication In Diabetes-Mediated Vascular Calcification, Amber Michelle Kennon
Influence Of Rage Signaling On Cellular Communication In Diabetes-Mediated Vascular Calcification, Amber Michelle Kennon
Electronic Theses and Dissertations
Chronic hyperglycemia is one of the main characteristics of type 2 diabetes mellitus (T2DM). With the increased prevalence of T2DM, the risk of cardiovascular complications, including heart attack or stroke, is increased. Complications linked to the vasculature are increased vascular calcification (VC) or mineral deposition within the medial layer of conducting arteries. Under calcification conditions, vascular smooth muscle cells (VSMCs) undergo an osteogenic switch to an osteoblast-like cell and begin producing bone proteins. Chronic hyperglycemia can also result in increased extracellular matrix (ECM) synthesis, accumulation, and crosslinking. One of the cell types responsible for increased ECM synthesis are ‘activated’ fibroblasts …
Hot-Melt Extrusion Based Fused Deposition Modeling 3d Printing Of Atorvastatin Calcium Tablets: Impact Of Shape And Infill Density On Printability And Performance, Preethi Mandati
Electronic Theses and Dissertations
The main objective of the current research is to investigate the effect of shapes (heart and round shape tablets) and infill densities (50% and 100%) on drug release profiles of tablets prepared by hot melt extrusion (HME) coupled fused deposition modeling (FDM) technique. Two different commercial FDM 3D printers with different filament feeding mechanisms were evaluated for suitability of printing. Drug-loaded filaments of 1.5 mm and 2.5 mm diameters were extruded using Process 11 mm HME, using atorvastatin as a model drug and Kollicoat® IR, Kollidon® VA64, Kollidon®12PF, and Kolliphor® P407 as hydrophilic polymers. Filaments of Kollicoat® IR in combination …
Responses Of Predatory Myxobacteria To Prey Signaling Molecules & Features Of A Pseudomonas Prey Avoiding Predation, Shukria Akbar
Responses Of Predatory Myxobacteria To Prey Signaling Molecules & Features Of A Pseudomonas Prey Avoiding Predation, Shukria Akbar
Electronic Theses and Dissertations
Gram-negative unicellular myxobacteria, along with their multicellular lifestyle andbiologically active specialized metabolites, are known for the predatory interactions with Gram-negative/ Gram-positive bacteria and fungi. Although myxobacterial predation range have been exploited extensively, little is known about the prey associated molecules contributing to myxobacterial predator-prey dynamics. By employing transcriptomics and untargeted metabolomics approaches, we demonstrate two structurally distinct classes of signaling molecules from Gram-negative bacterial prey elicit significant omics responses from myxobacteria, Myxococcus xanthus and Cystobacter ferrugineus. An overlapping and general response to acylhomoserine lactones, whereas a distinctive response to a quinolone signaling molecule is observed from both myxobacteria. Similarly, by …
Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr
Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr
Electronic Theses and Dissertations
Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle, which is thought to occur, in part, by increased AGE/RAGE signaling. Advanced glycation end products (AGEs) accumulate within the body over time, and under hyperglycemic conditions, the formation and accumulation of AGEs is accelerated. AGEs exert their effect by binding to their receptor (RAGE) and can induce myofibroblast differentiation, oxidative stress, cell-extracellular matrix contraction, and cell migration. Previous findings from our lab have demonstrated that preventing the production of Rap1a, a Ras-like GTPase signaling protein, in cardiac fibroblasts will decrease type 2 diabetes …
Manipulations Of A Memory Interference Paradigm, Lindsay Kyle Crawford
Manipulations Of A Memory Interference Paradigm, Lindsay Kyle Crawford
Electronic Theses and Dissertations
The AB/DE, AC/FG paired associate learning task, which has been utilized in numerous experimental studies, is purported to induce both proactive (PI) and retroactive interference (RI) simultaneously. However, until now, there have not been any studies validating or determining the optimal format of this paradigm. As such, the purpose of this series of experiments was to make manipulations to the task in order to maximize its efficacy. Across the series of experiments implemented herein, we manipulated various aspects of the paradigm (e.g., semantic relatedness of the word pairs, number of trials) driven by theoretical underpinnings of memory interference theory. Experiments …
Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott
Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott
Electronic Theses and Dissertations
Childhood sexual assault (CSA) is a growing problem in our society. A child who experiences a sexual assault not only deals with the immediate trauma surrounding this event, but also the aftermath of this event as they progress into adulthood. Trauma and sexual trauma is an umbrella term that incorporates all of the various implications of experiencing a negative event. In the instance of trauma, neurobiological implications have been well researched and established. This knowledge highlights the need for counseling techniques to be developed and studied that target those who have experienced CSA. The aim of this single-case research design …
The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall
The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall
Electronic Theses and Dissertations
Telepractice is a growing method in providing services in the profession of Speech-Language Pathology. One question with this growing method is, how do we build rapport when using telepractice? In this study, we intended to find what pediatric SLPs' perceptions and strategies of building rapport via telepractice is with children with autism spectrum disorder (ASD) ages 5-12, and children’s age was considered as an influential factor. While previous studies have focused on perceptions, we wanted to know what SLPs are doing in order to build rapport with their clients when using telepractice. We reached out to 223 SLPs and there …
The Accuracy Of Subjective Load Parameters In Comparison To Analytical Load Measurments In Ncaa Division I Women’S Volleyball, Katherine Pierce
The Accuracy Of Subjective Load Parameters In Comparison To Analytical Load Measurments In Ncaa Division I Women’S Volleyball, Katherine Pierce
Electronic Theses and Dissertations
Monitoring the work load of athletes in both an individual and team setting has become a commonplace practice in today’s age of sports. However, this practice can look different depending on the physical demands of the sport. Specifically, in volleyball, an inertial measurement unit, known as Vert, can be utilized to track the number of jumps performed by players, in addition to other jump related variables. While Vert serves as an effective way of objectively measuring jump frequency among players, other ways in which jump frequency can be estimated are needed for teams and players without Vert. Therefore, this study …
Abuse Deterrent Formulation Using Hot Melt Extrusion Technology, Vishvesh Raje
Abuse Deterrent Formulation Using Hot Melt Extrusion Technology, Vishvesh Raje
Electronic Theses and Dissertations
The purpose of the current study was to formulate hot melt extruded (HME) abuse deterrent pellets of acetaminophen(APAP), a model drug with the aid of high molecular weight hydroxypropyl methylcellulose (HPMC 4M ) and gelling agents (starch, pectin and carbopol). The formulated HME pellets were assessed for their abuse-deterrence (AD) potential using Category- 1 laboratory in-vitro evaluation standards. The pellets were examined for the particle size reduction (PSR), extraction in small volume, syringeability, thermal manipulation and dissolution for evaluating the resilience of the AD properties. Though, most of the formulation showed complete particle size reduction after grinding, grounded pellets were …
Applications Of Hot-Melt Extrusion (Hme) Technology And Investigation Of A Screening Tool For Hme, Gauri Deepak Shadambikar
Applications Of Hot-Melt Extrusion (Hme) Technology And Investigation Of A Screening Tool For Hme, Gauri Deepak Shadambikar
Electronic Theses and Dissertations
Hot-melt extrusion (HME), an adaptable technology, has established its position in manufacturing operations like amorphous solid dispersions, immediate and controlled oral formulations, implants and taste masked products. In recent years the industrial focus has shifted towards continuous manufacturing, thus HME is being explored for new applications. The aim of this research was to investigate the novel applications of HME by carrying out an in-depth study to understand the interaction between the process and product and to investigate a screening tool for its small-scale formulation and development.As HME consumes large amount of samples during the developmental phase, we investigated a screening …
Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins
Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins
Electronic Theses and Dissertations
Opioid receptors (OR) are expressed throughout both the peripheral and central nervous system and play crucial roles in the modulation of antinociception, addiction, anxiety, and depression. Salvinorin A, the main isolate of the hallucinogenic plant Salvia divinorum, is one of the most potent naturally occurring kappa opioid receptor agonists. Salvinorin A possesses beneficial effects as a therapeutic in a variety of CNS disorders, but due to its strong hallucinating, anxiogenic effects, and short half-life(t1/2), it has never advanced to clinical trials. Instead, salvinorin A has been used as an important prototype for the development of related drug candidates. Our initial …
Development Of Site - Specific Drug Delivery Systems Using Hot Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagireddy Reddy Dumpa
Development Of Site - Specific Drug Delivery Systems Using Hot Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagireddy Reddy Dumpa
Electronic Theses and Dissertations
Due to preferential site of drug absorption and the need for increased concentration of medication at the required tissues, dosage forms should be designed or formulated in such a way that medication is released at a specific site or after a specific time in the gastrointestinal tract (GIT). Knowledge of transit times of dosage forms in each part of GIT, by use of particular polymers or employing specific delivery systems such as floating systems, delivery of medication to specific sites in the GIT can be achieved. HME coupled FDM 3D printing has the capability to create customized dosage forms for …
Subcutaneous Delivery Of Albumin, Vy Nguyen
Subcutaneous Delivery Of Albumin, Vy Nguyen
Electronic Theses and Dissertations
An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. However, because of their large molecular sizes and high hydrophilicity, protein drugs are not orally bioavailable, which commonly require intravenous, intramuscular or subcutaneous injection. Thermosensitive polymers have been widely investigated as in situ depots for sustained drug release delivered through subcutaneous route.Albumin is the most abundant proteins in bloodstream. It has long half-life (19 days in human) and plays important roles such as acting as carrier for fatty acids, amino acids, waste products and medical compounds. Albumin has been studied for decades …
Isolation Of Marker Compounds From Copaiba Essential Oil And Mimosa Pigra For Quality Evaluation Of Dietary Supplements, Mohammed Hawwal
Isolation Of Marker Compounds From Copaiba Essential Oil And Mimosa Pigra For Quality Evaluation Of Dietary Supplements, Mohammed Hawwal
Electronic Theses and Dissertations
Natural products have been used as a primary means of treating illness since ancient times, and they remain an important pool of U.S. FDA approved drugs. Approximately 33% of all current pharmaceutical medications discovered between 1981 and 2014 are either natural products or derived from natural products (Newman and Cragg 2016). The process of isolating specialized metabolites from medicinal plants has led to the development of particularly important medicines worldwide (Rakotomalala, Agard et al. 2013) such as Taxol® from Taxus brevifolia Nutt. (Taxaceae) and salicylic acid from the bark of Salix spp. This research is composed of five chapters; the …
Responses Of Myxobacteria To Plant-Related Chemosignals Suggests Their Roles In The Rhizobiome, Barbara Iyare Adaikpoh
Responses Of Myxobacteria To Plant-Related Chemosignals Suggests Their Roles In The Rhizobiome, Barbara Iyare Adaikpoh
Electronic Theses and Dissertations
In the rhizosphere, plants curate and maintain distinct rhizobiome, some of which serve as secondary defense mechanisms against pathogenic microorganisms. Additionally, in response to biotic stress, plants generate phytohormones which regulate signaling pathways to activate systemic resistance. These phytohormones contribute to the chemical space within the rhizosphere in addition to other low-molecular-weight metabolites used for cell-to-cell communication within species and across kingdoms. However, little is known about the influences of stress-related phytohormones on beneficial bacteria even though biocontrol strategies abundantly explore plant-beneficial microorganisms to manage pathogens in agricultural systems. Myxobacteria are competent predators of plant pathogens and have demonstrated responses …
Development Of Ibuprofen Tablet With Polyethylene Oxide Using Fused Deposition Modeling (Fdm) 3d Printing Coupled With Hot-Melt Extrusion, Sooyeon Chung
Electronic Theses and Dissertations
Ibuprofen is known to plasticize several polymers used in the pharmaceutical field, and it is considered challenging to achieve an immediate release by fused deposition modeling (FDM). Therefore, this study aimed to print ibuprofen tablet with a focus on achieving immediate release. Polyethylene oxide (Polyox WSR N80) was used as a main matrix to form the ibuprofen filament due to its water-soluble property and manifesting suitable mechanical property even with the high drug loading (40% w/w). Several release modifiers such as Kollidon VA64, Kollidon 12PF, Kollicoat IR, Kollidon CL, and Mannitol were added separately to the formulation to enhance the …
Methylene Blue As Light And Reactive Oxygen Species Sensitive Ligand: Appicability In Hybrid Drug And Material Synthesis, Huy Dao
Electronic Theses and Dissertations
Methylene blue (MB) with a 10-N-carbamoyl linkage was discovered and developed as a multifunctional far-red (660 nm) photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch properties through the controlled release of MB. The released MB was successfully demonstrated to be an effective photosensitizer, imaging probe, and therapeutic agent. The complete release of MB was achieved with a cumulative light dose of 15 J/cm2. The photosensitivity was demonstrated to be dependent on the type of chemical bond at 10-N of the phenothiazine ring which links MB to a side group. Specifically, the urea bond-based …
Sleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregiverssleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregivers, Sushmitha Inguva
Electronic Theses and Dissertations
This dissertation aimed at filling gaps in the body of Parkinson’s disease (PD) and sleep literature by synthesizing and appraising current knowledge on the influence of sleep on health-related quality of life (HRQoL) in persons with Parkinson’s (PWP) and their caregivers, conducting a psychometric evaluation of a HRQoL instrument among PWP, and applying a novel method to assess the dyadic relationship between sleep and HRQoL in PWP and their caregivers. First, the systematic literature review results showed that nocturnal and diurnal sleep problems among PWP are strong predictors of their HRQoL. Additionally, studies that focused on caregiver outcomes showed that …
Understanding Willingness Towards Deprescribing Among Older Adults With Osteoporosis, Queenie Paltanwale
Understanding Willingness Towards Deprescribing Among Older Adults With Osteoporosis, Queenie Paltanwale
Electronic Theses and Dissertations
Objectives: To describe and identify the socio-behavioral factors predicting willingness towards deprescribing among older adults with osteoporosis.Design, Setting, and Participants: For this population-based survey study of US Medicare beneficiaries, data was obtained from the Medication Attitudes Module distributed to the participants in Round 6 (2015) of the National Health and Aging Trends Study. Our study population consisted to respondents who were diagnosed with osteoporosis in round 6 or earlier and who responded to the Medication Attitude Module. Main outcome and Measures: Response to the statement “I would like to reduce the number of medicines I am taking” was the main …
An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu
An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu
Electronic Theses and Dissertations
Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminoglycans (GAGs), which are involved in diverse biological processes. Although Hp/HS GAGs influence numerous physiological and pathophysiological processes, their high degree of size polydispersity and sequence microheterogeneity make structure-function characterization challenging. In addition, it is hard to understand the structures that underlie any of the various functions with MS, because of the lability of the sulfate group during tandem mass spectrometry (MS/MS) analysis. The work presented here describes an in-depth approach for functional oligosaccharide characterization including chemical derivatization of Hp to inhibit COVID-19 infection, multi-dimensional liquid chromatography (LC) fractionation method, chemical derivatization …
Effects Of Acute Exercise Intensity On Source Episodic Memory: Considerations By Cardiorespiratory Fitness, Brandon Thomas Rigdon
Effects Of Acute Exercise Intensity On Source Episodic Memory: Considerations By Cardiorespiratory Fitness, Brandon Thomas Rigdon
Electronic Theses and Dissertations
Prior research suggests that behavioral (e.g., acute exercise) and psychological factors (e.g., metamemory; monitoring and control of one’s memory processes) may influence memory function. However, there is conflicting results on the optimal intensity of acute exercise to enhance memory and whether acute exercise can also enhance metamemory. Further, very limited research has evaluated whether acute exercise can influence source episodic memory. The primary objective of this study was to evaluate whether there is an intensity-specific effect of acute aerobic exercise on source episodic memory and metamemory accuracy. A secondary objective was to evaluate if cardiorespiratory fitness moderates this potential relationship. …
The Efficacy Of Neurofeedback In The Treatment Of Individuals With Anxiety-Spectrum Disorders: A Meta-Analysis, Gordon Michael Russo
The Efficacy Of Neurofeedback In The Treatment Of Individuals With Anxiety-Spectrum Disorders: A Meta-Analysis, Gordon Michael Russo
Electronic Theses and Dissertations
A number of authors have published articles that assert the efficacy of neurofeedback (NFB) in the treatment of people with anxious symptomatology. Despite this, many insurance companies identify NFB as experimental, which prohibits individuals from utilizing benefits to obtain this therapeutic treatment. In order to examine these discrepancies, the present meta-analyses were conducted and guided by research questions designed to examine the overall effectiveness of NFB, the impact of participant characteristics, and identify the if there is a significant difference in anxiety-spectrum outcomes. Twenty-six trials were divided based on design (14 single group [SG]; 12 between group [BG]) and analyzed …
Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe
Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe
Electronic Theses and Dissertations
The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor that is implicated in a variety of physiological processes, such as energy homeostasis, appetite regulation, cognition and motor control, and mood regulation. CB1 is widely distributed throughout the body, but is mainly expressed in the brain. Molecules that reduce CB1 signaling exhibit anti-obesity properties due to their effect in reducing appetite and body weight gain. However, the consequence of reducing CB1 signaling in the CNS includes adverse neuropsychiatric effects such as depression and suicidal ideation. Two methods of scientific interest for developing CB1 antagonists as anti-obesity drugs are …
Towards A New Method Of Determining Protein Structure, Niloofar Abolhasani Khaje
Towards A New Method Of Determining Protein Structure, Niloofar Abolhasani Khaje
Electronic Theses and Dissertations
Hydroxyl radical protein footprinting (HRPF) by fast photochemical oxidation of proteins (FPOP) is a mass spectrometry-based technique that measures the apparent protein oxidation rate by freely diffusing hydroxyl radicals at different regions in a protein, and correlates changes in this apparent rate with changes in the solvent accessibility of the protein target based on quantifying the amount of oxidation of different regions of a protein. While there have been many advancements in HRPF-FPOP, oxidation measurement still suffers from high variability between measurements. High variability reduces the power statistical power this technique even in the presence of radical dosimetry measurements and …
Development, Optimization, And In Vitro Characterization Of Different Anesthetic Wound Products, Alia Alshammari
Development, Optimization, And In Vitro Characterization Of Different Anesthetic Wound Products, Alia Alshammari
Electronic Theses and Dissertations
ABSTRACTAcute and chronic wounds can be a significant source of pain. In the past, pain associated with chronic wounds has been perceived as an inevitable complication of wound care. Fortunately, recent approaches in wound care have developed strategies to prevent and reduce pain when carrying out wound care. Local anesthetics have been used to that end. Lidocaine is the most widely used topical anesthetic in wound care. However, literature on topical Lidocaine has focused almost exclusively on the clinical application on intact skin. This dissertation aims to advance our understanding of anesthetic wound product formulation and development. Anesthetic wound ointments …
The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell
The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell
Electronic Theses and Dissertations
Attention Deficit-Hyperactivity Disorder (ADHD) is currently the neurodevelopmental disorder most commonly diagnosed in children in the United States, and one of the defining characteristics of ADHD is inattention. Inattention is marked by increased lapses in attention, and when assessed clinically, it has been highly correlated with reaction-time variability (RTV). Evidence from the human/clinical literature has shown an inherently higher RTV to be the primary quantitative indicator of an ADHD diagnosis. Reaction-time distributions are characterized by an asymmetrical rightward skew, and because of the prevalence of this presentation, it has been theorized that the distribution peak and skew represent separate phenomena, …
Development Of Topical Oil/Peg Creams Of Voriconazole, Abhishek Shivashankar Shettar
Development Of Topical Oil/Peg Creams Of Voriconazole, Abhishek Shivashankar Shettar
Electronic Theses and Dissertations
Voriconazole (VRC) was selected as a model drug for preparation of Oil/PEG cream consisting of PEG 2000, PEG 400 and propylene glycol after performing drug-excipient compatibility studies. Twin screw processor with a 10 mm co-rotating twin screw configuration was used for preparation of oil/PEG creams. Creams prepared using twin-screw processor were characterized for the following: Differential Scanning Calorimetry (DSC), pH, Solvent activity (as)), viscosity, drug content uniformity, in vitro drug release testing (IVRT) and in vitro permeation testing (IVPT) using human cadaver skin. Creams are heterogenous biphasic semi-solid preparations consisting of oil and aqueous phases, wherein one phase is dispersed …