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Articles 1 - 30 of 231
Full-Text Articles in Medicine and Health Sciences
Motor And Sensory Characterization Of A Mouse Model Of Charcot-Marie-Tooth Type 2o Disease, Swaran Nandini
Motor And Sensory Characterization Of A Mouse Model Of Charcot-Marie-Tooth Type 2o Disease, Swaran Nandini
Electronic Theses and Dissertations
Dynein is an essential motor protein required for the maintenance and survival of cells. Dynein forms a motor complex to carry intracellular cargoes like organelles, growth factors, peptides, and hormones along the microtubules inside the cells. In neurons, the dynein is the retrograde motor protein that moves cargoes from the neuronal tip to the neuronal soma along the length of an axon. Dynein has an established role in neuronal nuclear migration, transport of neuronal survival signals and growth factors, organelle positioning inside neurons etc. Hence, it is not very surprising that numerous mutations in dynein have been reported in association …
Factors Influencing Unmet Medical Need Among U.S. Adults: Disparities In Access To Health Services, Ahmad Khanijahani
Factors Influencing Unmet Medical Need Among U.S. Adults: Disparities In Access To Health Services, Ahmad Khanijahani
Electronic Theses and Dissertations
Inequities in access to health services has negative consequences on individual well-being, and imposes financial and emotional burden on patients, families, health care systems, and the public. Inequities engendered from differences in socioeconomic status, health insurance coverage, race, and other characteristics can engender disparities. This study aimed to identify the potential predictors of unmet medical need among the civilian noninstitutionalized U.S. adults. Inability to receive needed medical care or receiving medical care after a delay, due to the associated costs, constructed unmet medical need. This study used a four-year (2014-2017) National Health Interview Survey (NHIS) data (sample size: 296,301 adults) …
Readability Of Patient-Reported Outcome Measures For Persons With Aphasia, Sara Gray
Readability Of Patient-Reported Outcome Measures For Persons With Aphasia, Sara Gray
Electronic Theses and Dissertations
The relationship between positive health outcomes in persons with aphasia (PWA) and personcentered care is highlighted by personally relevant information obtained directly from the PWA. Such is often facilitated via patient reported outcome measures (PROMs). In order to provide accurate responses to PROMs, PWAs must to read, comprehend, formulate and generate answers to a variety of questions. PROMs designed for other clinical populations assessed/treated by speech-language pathologists have been found to be largely unreadable. Despite the significant role of PROMs in assessment and management of aphasia, no study to date has examined the readability of these measures. Four readability formulae …
Implementation Of The Roles And Responsibilities Of Speech Language Pathologists In The Schools, Tamar Nir
Implementation Of The Roles And Responsibilities Of Speech Language Pathologists In The Schools, Tamar Nir
Electronic Theses and Dissertations
The purpose of this study was to determine how the roles and responsibilities of speech-language pathologists (SLPs) in schools are being implemented, whether speech-language pathologists in schools feel comfortable with their roles, and whether they are willing to engage in professional learning activities to hone knowledge and skills in role areas in order to inform pre-service and in-service learning This study utilized an online survey to collect responses. The survey included questions related to the rate of implementation, comfort level, and desire for further professional learning with regards to the roles and responsibilities prescribed by American Speech-Language Hearing Association (ASHA) …
A Deep Learning Approach To Diagnosing Schizophrenia, Justin Barry
A Deep Learning Approach To Diagnosing Schizophrenia, Justin Barry
Electronic Theses and Dissertations
In this article, the investigators present a new method using a deep learning approach to diagnose schizophrenia. In the experiment presented, the investigators have used a secondary dataset provided by National Institutes of Health. The aforementioned experimentation involves analyzing this dataset for existence of schizophrenia using traditional machine learning approaches such as logistic regression, support vector machine, and random forest. This is followed by application of deep learning techniques using three hidden layers in the model. The results obtained indicate that deep learning provides state-of-the-art accuracy in diagnosing schizophrenia. Based on these observations, there is a possibility that deep learning …
Factors Influencing Nurse Practitioners' Weight Management Practices In Primary Care, Suzanne Hyer
Factors Influencing Nurse Practitioners' Weight Management Practices In Primary Care, Suzanne Hyer
Electronic Theses and Dissertations
More American adults are overweight or obese than ever before. Nurse practitioners (NPs) play a critical and expanding role in primary care, which is an ideal setting for the assessment and management of weight loss. NPs can make a significant contribution to tackling the obesity crisis. The study presented here seeks to close the gap in data related to how NPs approach weight management with their primary care patients. This study focused on a comprehensive examination of the current practice patterns of NPs related to weight management, a theoretical concept analysis of weight bias among healthcare providers, along with the …
Predictors Of Hospital Quality And Efficiency, Hoda Fotovvat
Predictors Of Hospital Quality And Efficiency, Hoda Fotovvat
Electronic Theses and Dissertations
American hospitals have made serious efforts to implement and expand their health information technology capabilities and to integrate different specialized care or high-tech services in order to maximize the efficiency and quality of care. In providing a variety of HIT-related services, these hospitals expanded their national reputation in line with integrated care goals. As a result, hospitals are encouraged to establish effective communication channels to facilitate patient-physician sharing of the patient care experience, to enhance effective pain management, and to transform patient-centered care modalities to solidify the adequacy of patient care processes. By analyzing national data sets publicly available, this …
Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain
Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain
Electronic Theses and Dissertations
This study aimed to explore factors affecting seniors' intention to relocate to a senior living facility. More specifically, the purpose of this study was to examine the influence of push and pull motivational factors and perceived barriers on seniors' intention to relocate to a senior living facility (SLF). In addition, the mediating role of perceived barriers on the relationships between push motivational factors and intention to relocate and pull motivational factors and intention to relocate were explored. The data of the study was collected from 363 seniors. Structural equation modeling (SEM) analysis was conducted to test the study hypotheses. The …
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Electronic Theses and Dissertations
AB-type protein toxins have a catalytic A subunit attached to a cell-binding B subunit. Ricin, Shiga toxin (Stx), exotoxin A, and diphtheria toxin are AB toxins that act within the host cytosol and kill the host cell through pathways involving the inhibition of protein synthesis. Our overall goal is to help elucidate the cellular basis of intoxication for therapeutic development. According to the current model of intoxication, the effect of AB toxins is irreversible. To test this model, we developed a system that uses flow cytometry and a fluorescent reporter to examine the cellular potency of toxins that inhibit protein …
Unraveling Pdi And Its Interaction With Ab Toxins, Jessica Guyette
Unraveling Pdi And Its Interaction With Ab Toxins, Jessica Guyette
Electronic Theses and Dissertations
Protein disulfide isomerase (PDI) is an essential endoplasmic reticulum (ER) protein that acts as both an oxidoreductase and chaperone. It exhibits substantial flexibility and undergoes cycles of unfolding and refolding in its interaction with cholera toxin (Ctx), which is a unique property of PDI. This unfolding allows PDI to disassemble the Ctx holotoxin, which is required for Ctx activity. Here, we investigated the unfolding and refolding property of PDI and how this affects its interaction with bacterial toxins. PDI showed remarkable redox-linked conformational resilience that allows it to refold after being thermally stressed. Deletion constructs of PDI showed that both …
Modeling Disease Impact Of Vibrio-Phage Interactions, Christopher Botelho
Modeling Disease Impact Of Vibrio-Phage Interactions, Christopher Botelho
Electronic Theses and Dissertations
Since the work of John Snow, scientists and medical professionals have understood that individuals develop cholera by means of consuming contaminated water. Despite the knowledge of cholera's route of infection, many countries have experienced and still experience endemic cholera. Cholera is caused by the Vibrio cholerae (V. cholerae) bacterium and presents with acute diarrhea and vomiting. If untreated, infected individuals may die due to dehydration. Cholera is a disease that most commonly affects countries with poor infrastructure and water sanitation. Despite efforts to control cholera in such countries, the disease persists. One such example is Haiti which has been experiencing …
A Complete Approach To Predict Biodistribution Of Nanomaterials Within Animal Species From In-Vitro Data, Edward Price
A Complete Approach To Predict Biodistribution Of Nanomaterials Within Animal Species From In-Vitro Data, Edward Price
Electronic Theses and Dissertations
Smart drug-design for antibody and nanomaterial-based therapies allows for optimization of drug efficacy and more efficient early-stage pre-clinical trials. The ideal drug must display maximum efficacy at target tissue sites, but to track and predict distribution to these sites, one must have a mechanistic understanding of the kinetics involved with the individual cells of the tissue itself. This process can be tracked through biological simulations coupled with in-vitro approaches, which result in a rapid and efficient in-depth understanding of drug transport within tissue vasculature and cellular environment. As a result, it becomes possible to predict drug biodistribution within live animal …
Use Of Video-Enhanced Debriefing In Clinical Nursing Skill Acquisition: Indwelling Urinary Catheterization As An Exemplar, Erica Hoyt
Electronic Theses and Dissertations
Nursing students struggle to acquire and maintain clinical psychomotor skills. Hiring agencies bear the cost of retraining graduate nurses inept with skills learned early in their nursing curriculum. Improperly performed clinical skills pose a risk to patient safety, resulting in pain and suffering for the patient. This empirical study aimed to determine if video-enhanced debriefing (VED) improved initial skill validation scores, skill feedback, satisfaction with learning, and reduced skill decay among first-semester, pre-licensure BSN students performing female indwelling urinary catheterization (IUC) in a simulated clinical setting compared to no debriefing. Participants received standard instruction, then video-recorded their IUC skill. Participants …
It Takes Two To Tango: The Toxin-Chaperone Relationship, Alisha Kellner
It Takes Two To Tango: The Toxin-Chaperone Relationship, Alisha Kellner
Electronic Theses and Dissertations
Cholera toxin (CT) enters the cell via receptor-mediated endocytosis and travels in a retrograde fashion to the endoplasmic reticulum (ER). The catalytic A1 subunit (CTA1) is then displaced from the rest of the holotoxin, unfolds, and is exported to the cytosol where it regains an active conformation for the ADP-ribosylation of its G-protein target. We have shown that the cytosolic chaperones Hsp90 and Hsc70 are required for CTA1 translocation to the cytosol. We have also shown that both are able to independently bind and refold CTA1. Using libraries of CTA1-derived peptides, we have identified a single Hsc70 binding site, YYIYVI …
Ultrasound Measured Flexor Muscle Thickness In The Forearms Of Rock Climbers, Michael Marsala
Ultrasound Measured Flexor Muscle Thickness In The Forearms Of Rock Climbers, Michael Marsala
Electronic Theses and Dissertations
PURPOSE: To examine differences in the forearms of rock climbers using ultrasound to measure the muscle thickness of the finger flexors. METHODS: A total of 33 participants were recruited, 22 climbers (22.23 years; 68% male) and 11 controls (21.8; 55% male). Climbers provided self-reported ratings of their climbing ability, skill level, and preferred mode of climbing (e.g. sport climbing vs. bouldering). Anthropometric measures, including body fat percentage, were measured in all participants. Ultrasound measurements were taken with the participant lying on their back on a padded table with their dominant hand supinated. Muscle thickness measurements were taken at the forearm …
Stress, Coping, And Quality Of Life Among Parental Caregivers Of Children With Autism Spectrum Disorder, Dawn Turnage
Stress, Coping, And Quality Of Life Among Parental Caregivers Of Children With Autism Spectrum Disorder, Dawn Turnage
Electronic Theses and Dissertations
Purpose: Parental caregivers of children with Autism Spectrum Disorder (ASD) are exposed to stressors associated with the daily care of raising a child with a developmental disability, which may negatively impact parental quality of life (QOL). The specific aim of this study was to examine the relationships between demographic factors, stress, and coping among parental caregivers of children with ASD to determine whether predictors of QOL exist. Methodology: This study was descriptive, and an electronic survey was distributed to Florida parents of children, age 3-21 years old, diagnosed with ASD. The survey measured parent reported demographic factors, severity of the …
Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon
Development Of A Functional Testing Platform For The Sensory Segment Of The Neuromuscular Reflex Arc, Alisha Colon
Electronic Theses and Dissertations
Investigations of human biology and disease have been hindered by the use of animal models. The information obtained from such studies often results in clinically irrelevant results and drug trial failures. Additionally, several governing bodies have been formulating legislation to move away from animal models and toward more ethical and efficient testing platforms for drug discovery and cosmetic research. As an answer to these issues, "body-on-a-chip" systems have been a rapidly developing field which easily recapitulates in vivo functionality, providing a more relevant, repeatable, and ethical testing platform to better predict biology. These systems can be used as human-based testing …
Role Of Tnfα Antagonists And Genetic Polymorphisms In Modulating Susceptibility To Mycobacterial Infection Among Patients With Crohn's Disease, Ahmad Qasem
Electronic Theses and Dissertations
Tumor Necrosis Factor alpha antagonists (anti-TNFα) have been extensively used for Crohn's disease (CD) treatment. Even though they may control CD symptoms initially, treatment response varies among patients, which seems to depend on single nucleotide polymorphisms (SNPs) in TNFα receptors superfamily 1A and 1B (TNFRSF1A/B). Most importantly, M. tuberculosis infection has been strongly associated with these medications, but no studies have elucidated the effects of anti-TNFα on CD associated with MAP (Mycobacterium avium subspecies paratuberculosis; a possible causative agent of CD, and closely related to M. tuberculosis). Here, we investigated the effects of recombinant inflammatory cytokines and anti-TNFα therapeutics on …
Synthesis And Bioevaluation Of Methionine Depletion Agents, Houssine Ikhlef
Synthesis And Bioevaluation Of Methionine Depletion Agents, Houssine Ikhlef
Electronic Theses and Dissertations
The native polyamines (putrescine, spermidine, and spermine) are low molecular weight amines that exist as polycations at physiological pH. These polycations interact with DNA, RNA, and influence many cellular processes. Intracellular polyamine levels are maintained via a balance of polyamine biosynthesis, catabolism, and transport. Ornithine, an amino acid obtained from L-arginine, is decarboxylated by ornithine decarboxylase (ODC) to form putrescine. The biosynthesis of the higher polyamines, spermidine and spermine, requires the addition of an amino-propyl group donated by decarboxylated S-adenosylmethionine (dc-SAM), which itself is derived from the amino acid L-methionine (Met). Tumor cells are heavily reliant on methionine because it …
Macrolinguistic Analysis Of Discourse Production In People With Aphasia, Individuals With Mild Cognitive Impairment, And Survivors Of Traumatic Brain Injury, Stephanie Eaton
Electronic Theses and Dissertations
This study examined the macrolinguistic features of three genres (single picture description, sequential picture description, and story retell) of discourse samples collected from participants with acquired communication disorders (including two speakers with aphasia, two with mild cognitive impairment, and two with traumatic brain injury) and unimpaired controls (n=6). Comparisons were made to investigate group and genre differences. Standardized assessment scores of cognitive and linguistic evaluations were collected and correlated to features of macrolinguistic discourse analysis. Participants with acquired communication disorders performed best on the story retell discourse task compared to single picture description and sequential picture description. Significant measures for …
Evaluation Of Postoperative Air Leak And Chest Tube Drainage Systems After Pulmonary Resection, Kristina Jacobsen
Evaluation Of Postoperative Air Leak And Chest Tube Drainage Systems After Pulmonary Resection, Kristina Jacobsen
Electronic Theses and Dissertations
Postoperative air leaks are the most common complication after a pulmonary resection. There is no data in the literature comparing the traditional and digital chest drainage system after a robotic-assisted pulmonary lobectomy. In 182 eligible patients, this retrospective study evaluated the association between digital and traditional drainage systems with postoperative chest tube days, hospital length of stay, chest tube reinsertion during hospitalization, and 30-day readmission for pneumothorax following a robotic-assisted lobectomy. The groups did not differ significantly in terms of age, gender, BMI, smoking, adhesions or neoadjuvant therapy. Patients with the digital drainage system had a mean chest tube duration …
Fabrication Of Polyelectrolyte Nanoparticles Through Hydrophobic Interaction, Ruginn Porce Catarata
Fabrication Of Polyelectrolyte Nanoparticles Through Hydrophobic Interaction, Ruginn Porce Catarata
Electronic Theses and Dissertations
Anticancer drugs like gemcitabine (GEM) are used to treat cancers such as, pancreatic ductal adenocarcinoma (PDAC). However, the use of free gemcitabine yields challenges including cytotoxicity to healthy cells and poor circulation time. By encapsulating GEM in nanoparticles these challenges can be overcome. In this study poly(acrylic acid) (PAA)-GEM nanoparticles are fabricated by coupling GEM onto PAA. The particle formation is driven by the hydrophobic interaction of GEM, which collects in the core of the nanoparticle, forming a PAA shell. The nanoparticles were optimized by studying the PAA/GEM ratio and pH during fabrication. Characteristics of the nanoparticles including size, morphology …
Partnering With Paraprofessionals: Expanding Preschool Children's Responses Through Dialogic Reading, Juliana Hirn
Partnering With Paraprofessionals: Expanding Preschool Children's Responses Through Dialogic Reading, Juliana Hirn
Electronic Theses and Dissertations
Shared interactive reading is an evidence-based practice where professionals can collaborate to promote literacy and language skills in young children. Providing children with developmental disabilities (DD) the opportunity to gain language and preliteracy skills in early intervention is critical for their development as they are at a higher risk for falling behind in academics compared to their age-matched peers. This study evaluated the effectiveness of dialogic reading (DR) for children with DD. DR has been shown to be an effective strategy to teach typically developing preschool-aged children vocabulary, language, and literacy skills, however research in children with DD is limited. …
Mapping Addiction: A Digital Psychogeographic Approach To America's Addiction Epidemic, Clayton Benjamin
Mapping Addiction: A Digital Psychogeographic Approach To America's Addiction Epidemic, Clayton Benjamin
Electronic Theses and Dissertations
Focusing on policy consultation, my dissertation consults on the current US addiction epidemic and aims to answer, "What is our disposition to addiction?" Borrowing and clarifying Ulmer's MEmorial method, as established in his text Electronic Monuments, the dissertation combines the ancient Greek practice of theoria, Deleuzian theory, and psychogeographic counter-mapping methods to trace ways in which ideological apparatuses construct addiction. The aim of the dissertation is to reveal an abject value by constructing MEmorials which provide space for individuals to mourn loss and see their relation to that loss. Through mourning, individuals strengthen their ties to other community members and …
Mechanism Of Nanogp8 In Glioblastoma Multiforme, Jonhoi Smith
Mechanism Of Nanogp8 In Glioblastoma Multiforme, Jonhoi Smith
Electronic Theses and Dissertations
Glioblastoma multiforme (GBM) is an incurable brain tumor, with patients only expecting to live 15 to 16 months post-diagnosis with the most current treatments options including surgery, chemotherapy, and radiation. How GBM resist treatment is still not very well known. However, cancer stem cells (CSCs), a subset of cells in GBM tissue considered responsible for therapeutic resistance and the poor patient prognosis. NANOG, a homeobox gene, is responsible for maintaining pluripotency of embryonic stem cells and is observed in CSCs. NANOGP8, a retrogene in the NANOG family is expressed in CSCs and provides cells with stem-like characteristics previously observed in …
Development Of 3d Printed And 3d Metal-Based Micro/Nanofabricated, And Nano-Functionalized, Microelectrode Array (Mea) Biosensors For Flexible, Conformable, And In Vitro Applications, Charles Didier
Electronic Theses and Dissertations
Emerging fields such as "Organs on a Chip", disease modeling in vitro, stem cell manufacturing and wearable bioelectronics are demanding rapid development of 3D Microelectrode Arrays (MEAs) for electrical interfacing with biological constructs. The work reported in this thesis focuses on two developmental tracks: "Dynamic 3D MEAs" and metal microfabrication for 3D MEAs. In the first part of the thesis, we explore the capabilities and limitations of 3D printed microserpentines (µserpentines) and utilize these structures to develop dynamic 3D microelectrodes. Analytical modeling of µserpentines flexibility followed by integration into a flexible Kapton® package and PDMS insulation are demonstrated. These 3D …
Life Partner Perceptions Of The Emotional Impact Of Stuttering, Athanasia Svenning
Life Partner Perceptions Of The Emotional Impact Of Stuttering, Athanasia Svenning
Electronic Theses and Dissertations
The aim of the present study is to investigate the extent to which life partners understand the emotional impact stuttering has on their loved one who stutters. This was accomplished by administering the Speech Situation Checklist - Emotional Reaction (SSC-ER), a subtest of the Behavior Assessment Battery (BAB; Vanryckeghem & Brutten, 2018) via Qualtrics, an online survey software, to the participants who stutter and a modified version of the SSC-ER to their life partner. No significant differences and a positive correlation were observed between groups (people who stutter (PWS) and their life partner (LP) as it relates to total score …
Academic Advisors' Attitudes Toward Students Experiencing Mental Health Issues, Danielle Aming
Academic Advisors' Attitudes Toward Students Experiencing Mental Health Issues, Danielle Aming
Electronic Theses and Dissertations
As students continue to pursue higher education, the potential for them to experience mental health issues will exist (National Alliance on Mental Illness, 2011; Center for Collegiate Mental Health, 2012; Gruttadaro & Crudo, 2012; Salzer, 2012; Center for Collegiate Mental Health, 2013). When entering a new environment, students will look to make connections with the institution; one of these connections can be with an academic advisor (Harper & Peterson, 2005; Harper & Wilson, 2010; Kuh, 2011; Pearson, 2012). It is important for individuals experiencing mental health issues to make connections to the institution so that they are more likely to …
Exacerbation Of Δefp Sickness In Escherichia Coli By An Uncharacterized Rna Helicase, Robert Wingo
Exacerbation Of Δefp Sickness In Escherichia Coli By An Uncharacterized Rna Helicase, Robert Wingo
Electronic Theses and Dissertations
In Escherichia coli, growth is rate-limited by translation capacity [1]. Stalled ribosomes have profound effects on a cell such as altered mRNA abundance, decreased ribosome availability, and an imbalanced proteome. The absence of elongation factor P (EF-P), a universally conserved transpeptidation enhancer, presents an extreme example of this scenario, wherein ribosomes accumulate disproportionately onto messages that are more slowly translated and cell growth becomes notably impaired. We discovered that faster-growing cells arise spontaneously in Δefp cultures, suggesting that translation defects could be circumvented by mutating other genes. This thesis presents a genetic and biochemical analysis of a mechanism Δefp cells …
Embryonic Stem Cell Derived Exosomes Enhance Cardiac Stem Cell Differentiation Into Heart Cells, Jamillah Hammond
Embryonic Stem Cell Derived Exosomes Enhance Cardiac Stem Cell Differentiation Into Heart Cells, Jamillah Hammond
Electronic Theses and Dissertations
Transplantation of embryonic stem (ES) cells into the ischemic and infarcted heart has proven to repopulate cardiac cell populations, attenuate structural cardiac remodeling, and rescue cardiac function. Unfortunately, the pluripotency of ES cells increases risk of teratoma formation in vivo. Exosomes, smaller in comparison to ES cells, are cell free carriers of miRNA, proteins, and lipids, and do not suggest risk of teratoma formation. Exosomes have been proposed to mediate and attenuate regeneration following myocardial infarction (MI), however, the role of exosomes derived from ES cells (ES-Exo) in activating resident cardiac stem cells (CSCs) to undergo cardiac differentiation is not …