Medicine and Health Sciences Commons^™

A Case Of Ruptured Cornual Pregnancy With Delivery Of A Viable Pre-Term Infant, Elana Miller, Elena Fuell-Wysong, Marilyn Kindig

Medical Student Research Symposium Abstracts and Posters

Interstitial and cornual ectopic pregnancies are rare forms of ectopic with high mortality rate. As such, they pose significant challenges in diagnosis, treatment, and follow up.

This patient was a 42 y/o female G2P1001 at 25+3 weeks gestational age who presented from an outside hospital after an episode of sudden onset abdominal pain with syncope. She was noted to have hypotension, tachycardia, lactic acidosis, and peritoneal free fluid. Physical exam was significant for peritoneal signs with abdominal guarding and rebound. Her pregnancy was complicated by advanced maternal age, THC use, and late presentation for prenatal care in the second trimester. …

Human Trafficking Education For 3rd Year Medical Students, Michelle Adamczyk, Ilana Siegal, Musunga Mulenga, Jeannette Manger

Medical Student Research Symposium Abstracts and Posters

Human trafficking is both a global and local human rights issue involving the exploitation of victims for labor or sex. Cases of human trafficking have been reported in every U.S. state, and victims of human trafficking include both minors and adults. Many victims of human trafficking will visit a health care setting during the time they are under the control of their trafficker. This allows health care providers the opportunity to play a key role in identifying and intervening to help victims of human trafficking, particularly while they are in the more controlled health care setting. The goal of this …

The Role Of Implantable Cardioverter Defibrillators For The Prevention Of Ventricular Arrhythmia In Left Ventricular Assist Device Recipients, Nikhil Reddy, Cristina Ortiz, Toshimasa Okabe, Muhammad Afzal, Mohamed H. Derbala, Asvin Ganapathi, Sakima Smith

Medical Student Research Symposium Abstracts and Posters

Advanced heart failure represents a significant strain on our health care system and is associated with increased morbidity and mortality. New device therapies, including left ventricular assist device (LVAD) implantation, have transformed management as both a destination therapy and as a bridge to transplantation. Although LVADs have improved patient outcomes, arrhythmias represent a significant and costly complication of this therapy. In recent years, implantable cardioverter-defibrillators (ICDs) have been developed to reduce the incidence of lethal arrhythmia. However, a gap in the literature exists for both guidelines in prevention of early ventricular arrhythmia (VA) in LVAD recipients and the effectiveness of …

Endoplasmic Reticulum Stress Induces Axon Initial Segment Shortening In Cortical Neuron Culture, Jennae Shelby, Ryan B. Griggs, Josef Steinbrunner, Keiichiro Susuki

Medical Student Research Symposium Abstracts and Posters

The axon initial segment (AIS) is a domain located between the neuronal soma and axon responsible for action-potential initiation. Because even small changes in its length or location alter neuronal excitability and function, the AIS is a key structure for neurodegenerative pathophysiology. AIS shortening is seen in several neurodegenerative conditions such as traumatic brain injury, Alzheimer’s disease, neuropathic pain, multiple sclerosis, and diabetic encephalopathy. Diabetic encephalopathy refers to mild cognitive impairment or dementia often experienced in patients with type 2 diabetes. Although patients with type 2 diabetes are 1.73 times more likely to develop dementia, there is currently no course …

A Review Of Identified Barriers To Sunscreen Adherence For Skin Cancer Protection, Kaitlynne Pak, Ericson Torralba, Clayton Connor, Julian J. Trevino

Medical Student Research Symposium Abstracts and Posters

Skin cancer is the most common cancer in the US and worldwide. A clear risk factor for all types of skin cancer (basal cell carcinoma, squamous cell carcinoma, and melanoma) is UV exposure, whether artificial or natural. It is well-understood that regular sunscreen use with an SPF of 30 or greater reduces the risk of skin cancers; and especially that of melanoma, which is responsible for a majority of skin cancer deaths. However, the annual incidence of skin cancer cases, including melanoma, continues to rapidly rise in recent years. This may have a strong association with low rates of daily …

Magnitude Based Inference, Sharlo Bayless, Trevor J. Bihl

Medical Student Research Symposium Abstracts and Posters

Though its use is widespread in research, null hypothesis significance testing is not without flaws. Out of a desire to provide a more practical approach to solving statistical problems in certain fields, Magnitude Based Inference (MBI) was created. MBI is a statistical method that was developed by Will G Hopkins and Alan M Batterham, two researchers in Sports and Exercise Science, in 2009.The main issues that they wanted to address with null hypothesis significance testing (NHST),were: 1) the need for a large sample size,2) the confusing language, and 3) the arbitrary selection of a p value of 0.05 in testing …

Triamcinolone With Vitamin D Synergistic Efficacy In Psoriasis, Steven Repas, Jeffrey B. Travers

Medical Student Research Symposium Abstracts and Posters

Psoriasis is one of the most common skin conditions in the United States affecting more than 8 million people. High amounts of vitamin D has been shown to be effective in treatment of psoriasis. It also has a well-documented safety profile at the doses and duration that will be used during this study. Triamcinolone and other topical corticosteroids are considered a first line treatment for mild to moderate psoriasis with a well-documented safety profile. Individually both of these medications have shown effectiveness in the management and treatment of mild to moderate psoriasis. This study is designed to test whether a …

Is Microscopic Colitis Associated With Increased Risk For Other Gastrointestinal Diseases?, Tanner Graves, Paul Koles

Medical Student Research Symposium Abstracts and Posters

Microscopic colitis is clinically suspected in patients with recurrent watery diarrhea and the absence of gross pathologic changes in the colon by endoscopic examination. The diagnosis is established only by microscopic evaluation of colonic biopsies. Microscopic colitis is currently classified into three subgroups: collagenous colitis (CC), lymphocytic colitis (LC), and combined CC and LC. The incidence rates are 4.14 per 100,000 person-years and 4.85 per 100,000 person-years for CC and LC, respectfully.

Diagnosis is typically made without measuring the exact thickness of the subepithelial collagen band or by counting the number of lymphocytes in the epithelium. There is little research …

Methamphetamine Associated Cardiomyopathy And Fatal Thrombus Formation, Kaitlynne Pak, Sanuri Gunawardena, Ericson Torralba, Juan Linares, Damian Valencia, Nathaniel Dittoe

Medical Student Research Symposium Abstracts and Posters

Stimulant abuse is a rapidly growing epidemic both in the United States, and around the world. Reports show that nearly 4.7 million Americans have tried methamphetamines at least once. It is known that methamphetamines and related compounds significantly increase cardiovascular morbidity and mortality. Substance-related chronic inflammation and tissue fibrosis can cause irreversible cardiac structural changes, leading to conditions like methamphetamine-associated dilated cardiomyopathy (MACM). Left ventricular dilation results in hemodynamic flow disturbances, which promote turbulent blood flow and stagnation. Furthermore, the sympathomimetic effects of methamphetamines also disrupt pathways in coagulation homeostasis, providing further incitement of thrombus formation. This unstable catecholamine driven …

Global And Local Service Connection: Global Health Experiences And Local Community Engagement In Wright State University Boonshoft School Of Medicine Alumni, Katie Lomeo, Katharine A. Conway, Kelly Muterspaw, Kaitlyn Danner, Virginia Keim

Medical Student Research Symposium Abstracts and Posters

The Global Health Scholars Program (GHSP) at Wright State University Boonshoft School of Medicine (BSOM) has been in place for 18 years. The GHSP gives medical students an opportunity to serve in various medical settings around the world. There are many reasons why healthcare professionals seek global health experiences. One main reason for global health participation is altruism and the desire to improve community health abroad. However, global health participants are widely criticized for neglecting their home countries’ problems to solve those around the world. The goal of this study is to assess the relationship between global health experiences and …

Normocomplementemic Urticarial Vasculitis In A Pediatric Patient: Case Report And Literature Review, Kristin Petit, Thomas Selby, Julian J. Trevino

Medical Student Research Symposium Abstracts and Posters

Urticarial vasculitis (UV) is a rare type of leukocytoclastic vasculitis characterized by urticarial skin lesions lasting greater than 24 hours and is often associated with angioedema, post-inflammatory hyperpigmentation, and cutaneous dysesthesia. Initially, painful or pruritic wheals are arranged on the trunk, proximal extremities, or face and progress to purpura or ecchymosis. UV is most commonly reported in women in the fourth and fifth decades of life; cases of UV in children are rare. In children, UV is often preceded by upper respiratory tract infections however drug-induced UV has also been reported with the use of penicillins and non-steroidal anti inflammatory …

Uvb-Induced Microvesicle Particle Release In Human Skin In Vivo Is Diminished Following Oral Vitamin C And E Antioxidant Administration, Benjamin Schmeusser, Cameron Mcglone, Jeffrey B. Travers

Medical Student Research Symposium Abstracts and Posters

An important question in photobiology asks how Ultraviolet B (UVB, 290 – 320 nm) radiation, which mostly absorbs in the outer epidermis of skin, can generate a systemic response such as immunosuppression. Previous in vitro and ex vivo studies demonstrate UVB-dependent release of bioactive molecule-containing microvesicle particles (MVPs) from keratinocytes. Furthermore, MVP release is diminished upon antioxidant administration. The purpose of this study is to examine UVB-induced MVP release and antioxidant response in vivo. In this IRB-approved study, 8 male participants with Fitzpatrick type I or II skin were treated with 1000 J/m2 UVB irradiation to a 5 by 5 …

Prior Education And Medical School Achievement: An Analysis Of Elective Courses Impact In A Flipped Classroom, Malavika Pia Sengupta, Amber Todd

Medical Student Research Symposium Abstracts and Posters

Medical school curricula change rapidly, moving from a purely lecture-based format in the early 20th century to today’s organ system-based courses, problem-based learning, and clinical correlations earlier in the medical school experience. The American Association of Medical Colleges (AAMC) describes the minimum required courses for medical school to be 1 year each of biology, physics, English, and 2 years of chemistry. Many core classes in medical school are not addressed these required courses. This study examines whether taking foundational yet non-required courses, such as (1) anatomy, (2) immunology/microbiology, and (3) biochemistry prior to matriculation to medical school increases the likelihood …

Reconstructionof Congenital Arhinia With Stereolithography, Kelly Spiller, Kaitlynne Pak, Lucas M. Harrison, Spencer Anderson, Steven Schmidt, Salim Mancho

Medical Student Research Symposium Abstracts and Posters

Complete congenital arhinia is a rare defect of embryogenesis leading to the absence of the external nose and nasopharyngeal airway. In this study, we report our novel multi-staged reconstructive approach of congenital arhinia in addition to literature review. Reconstruction was achieved via several spaced operations. A nasal methyl methacrylate prosthesis was first created from a stereolithographic model for use as a temporary prosthesis and tissue expander. Lefort 1 osteotomy with cannulization was then utilized for midface advancement and nasopharyngeal airway formation. External nasal framework was constructed with bilateral conchal bowl cartilage and rib osteocartilagenous grafts. The patient was overall pleased …

Fluorescence-Guided Surgical Debridement Of Chronic Osteomyelitis Utilizing Doxycycline Bone Labeling: A Technical Trick Revived, Garrhett G. Via, David A. Brueggeman, Grant M. Slack, James M. Danias, Jennifer L. Jerele

Medical Student Research Symposium Abstracts and Posters

The present manuscript discusses the concept of fluorescence-guided surgical debridement of chronic osteomyelitis in the orthopaedic patient based upon a two-fold mechanism, natural fluorescence of healthy bone combined with bone labeling by tetracyclines. The senior author prefers preoperative administration of oral doxycycline 100 mg twice daily for at least 1 month. The excitation source of choice is an ordinary blacklight, as this is both cost-effective and readily attainable. Intraoperatively, viable bone is noted to fluoresce a greenish hue which is then used to guide the debridement. Previous studies have demonstrated that bleeding bone is not a reliable indicator of a …

Evaluating The Effectiveness Of Early Exposure: Obstetrics And Gynecology Two-Week Virtual Elective, Elisabeth N. Adkins, Marilyn Kindig, Rose A. Maxwell

Medical Student Research Symposium Abstracts and Posters

Clinical clerkships are an integral part of undergraduate medical education. Until now, clerkships have either been offered through simulation labs, didactics or in the healthcare setting dependent upon the pedagogical approach of each institutions’ curricula. Subsequent to coronavirus-2019, medical students had decreased accessibility to the aforementioned educational settings. This has provided an innovative opportunity for clerkship directors to provide the same clinical experience to students in a novel way –virtually.

Recently, the Larner College of Medicine at the University of Vermont created a two-week virtual simulated clerkship electiveencompassing the curricula taught throughout the OB/GYN clerkship. Until now, this virtual elective …

Neonatal Health Outcomes Following Water Immersion During Labor And Delivery, Ariel L. Lanier, Samantha L. Wiegand, David Mckenna

Medical Student Research Symposium Abstracts and Posters

Water birth is child delivery that occurs in a tub of water. Water birth delivery has been offered by Miami Valley Hospital in the Family Beginnings Birth Center since 1994. The first water birth delivery that was documented in a medical journal occurred in France in 1805, which reported that the delivery resulted in a healthy baby. Water birth deliveries have been growing in popularity in the United States as mothers are interested in the possible alleged benefits of water birth including shorter labor, less pain, improved maternal experience of childbirth, and more. Although there are many potential benefits, The …

Domestic Currency As A Foreign Body, Nikhil Reddy, Long Vu, Sangeeta Agrawal

Medical Student Research Symposium Abstracts and Posters

Foreign body ingestion is most commonly described in children, however this event can occur in adults as well. In Western countries, the most common cause of esophageal foreign bodies in adults is meat, while coins represent the most common object found in children. Symptoms of foreign body ingestion include sensation of a foreign body, chest pain, dysphagia, and vomiting. In 80% of cases, the foreign body is passed naturally. However, complications of retained esophageal foreign bodies can be life-threatening; therefore, emergent esophagogastroduodenoscopy (EGD) within 2-6 hours is recommended for ingestions of sharp objects, batteries, or those causing complete esophageal obstruction. …

Placental Hypoxia-Inducible Factor 1 Alpha In Early-Onset Preeclampsia As A Predictor Of Future Risk In Maternal And Fetal Health, Julie Slyby, Bryce Linkous, Sarah Scott, Chandni Chandiramani, Amy Hwang, Danielle Spanbauer, Melissa R. Kaufman, Traci Rackett, Kailey Nolan, Emily Stone, Rose A. Maxwell, David N. Dhanraj, Thomas L. Brown

Medical Student Research Symposium Abstracts and Posters

Preeclampsia is a life-threatening, pregnancy-associated disorder characterized by the rapid development of hypertension with renal dysfunction. While preeclampsia generally occurs later in pregnancy, early-onset preeclampsia (EOPE) can occur much earlier and is usually more devastating. Early-onset preeclampsia is also associated with an increased risk of maternal cardiovascular and metabolic disease in mothers later in life and neurocognitive dysfunction in their offspring. EOPE is strongly associated with abnormal placental development and fetal growth restriction during pregnancy.

Oncofertility Awareness And Attitudes Among Health Care Providers And Breast Cancer Patients In A Chinese Academic Setting1, John P. Zucal, Ewelina Biskup, Xin Zhaochen, Yun Sun, Yao Lu, Leslie C. Appiah, Hongwei Zhang, Steven R. Lindheim

Medical Student Research Symposium Abstracts and Posters

As cancer has become a major public health issue in China, fertility preservation remains limited despite the wide application of Assisted Reproductive Technology (ART) throughout the country.

Local Wound Infiltration With Liposomal Bupivacaine Decreases Post-Cesarean Pain Scores, Avni Gupta, Justin Williams, Rose A. Maxwell, Marilyn Kindig

Medical Student Research Symposium Abstracts and Posters

Surgical patients are routinely prescribed opioid analgesics that are strongly associated with drug overdose deaths. Liposomal bupivacaine is a long-acting local anesthetic that received FDA approval in 2011 for local surgical site infiltration to promote post-operative analgesia. This anesthetic has demonstrated an improvement in post-operative pain control in various surgical realms, indicating a decreased need for opiates and subsequently decreased risks. However, few studies have investigated its use at the time of cesarean delivery.

Disparities In Health Care Utilization And The Effect Of Family Resilience And Neighborhood Support, Temitope Omoladun, Nora L. Vish

Medical Student Research Symposium Abstracts and Posters

Resilience, the ability to recover from adversity and turn obstacles into strengths and successes, can mitigate negative health outcomes associated with external drivers of health. Poverty, low educational attainment, insurance status and marginalized communities along with adverse childhood events are all known to be associated with poor health outcomes. Resilience is increasingly understood as a potent mitigating factor of negative health outcomes associated with toxic stress and social determinants of health. Individual resilience itself is impacted by external drivers such as family resilience and community cohesion.

Medical homes seek to promote patient well-being by establishing a partnership of trust and …

Proceedings - Wright State University Boonshoft School Of Medicine Thirteenth Annual Medical Student Research Symposium, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Thirteenth Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 29, 2021.

The Mechanism Underlying Transient Weakness In Myotonia Congenita, Jessica H. Myers, Kirsten Denman, Chris Dupont, Ahmed A. Hawash, Kevin R. Novak, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A. Voss, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years of study. We performed intracellular recordings from muscle of both genetic and pharmacologic mouse models of Becker disease to identify the mechanism underlying transient weakness. Our recordings reveal transient depolarizations (plateau potentials) of the membrane potential to -25 to -35 mV in the genetic and pharmacologic models of Becker disease. Both Na + and Ca 2+ currents contribute to plateau potentials. Na + persistent inward current (NaPIC) through Na V 1.4 channels is the …

Challenges And Opportunities In Food Safety-A Review, Iram Asim, Humaira Yasmeen

Journal of Bioresource Management

Food-borne diseases are the group of disorders that are caused by consuming food having microbial existence in it. So safe food handling is to make sure the lessening of detrimental effects in growth to the packaging of food to minimize health issues on consumers which otherwise can lead to large scale disease outburst. This review concludes the findings of the studies on how food is being handled from farm to fork, how airlines are contributing towards the spreading of diseases, how any negligence in any one of the steps can cause havoc to mankind in the light of the recent …

Dosing Recommendations For Vancomycin In Children And Adolescents With Varying Levels Of Obesity And Renal Dysfunction: A Population Pharmacokinetic Study In 1892 Children Aged 1–18 Years, Cornelis Smit, Sebastiaan C. Goulooze, Roger J. M. Brüggemann, Catherine M. Sherwin, Catherijne A. J. Knibbe

Pediatrics Faculty Publications

Vancomycin is an effective but potentially nephrotoxic antibiotic commonly used for severe infections. Dosing guidelines for vancomycin in obese children and adolescents with or without renal impairment are currently lacking. This study describes the pharmacokinetics of vancomycin in a large pediatric cohort with varying degrees of obesity and renal function to design practical dosing guidelines for this population. A multi-center retrospective population pharmacokinetic study was conducted using data from patients aged 1−18 years who received >1 dose of vancomycin and had ≥1 vancomycin concentration measured between January 2006 and December 2012. Besides pharmacokinetic data, age, gender, body weight, creatinine clearance …

Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation-Induced Systemic Immunosuppression, Langni Liu, Azeezat A. Awoyemi, Katherine E. Fahy, Pariksha Thapa, Christina E. Borchers, Benita Y. Wu, Cameron L. Mcglone, Benjamin Schmeusser, Zafer Sattouf, Craig A. Rohan, Amy R. Williams, Elizabeth E. Cates, Christina Kinsely, Lisa E. Kelly, Ji C. Bihl, David R. Cool, Ravi P. Sahu, Jinju Wang, Yanfang Chen, Christine M. Rapp, Michael G. Kemp, Ron Michael Johnson, Jeffrey B. Travers

Dermatology Faculty Publications

A complete carcinogen, ultraviolet B (UVB) radiation (290–320 nm), is the major cause of skin cancer. UVB-induced systemic immunosuppression that contributes to photocarcinogenesis is due to the glycerophosphocholine-derived lipid mediator platelet-activating factor (PAF). A major question in photobiology is how UVB radiation, which only absorbs appreciably in the epidermal layers of skin, can generate systemic effects. UVB exposure and PAF receptor (PAFR) activation in keratinocytes induce the release of large numbers of microvesicle particles (MVPs; extracellular vesicles ranging from 100 to 1000 nm in size). MVPs released from skin keratinocytes in vitro in response to UVB (UVB-MVPs) are dependent on …

A Mouse Model Of Huntington’S Disease Shows Altered Ultrastructure Of Transverse Tubules In Skeletal Muscle Fibers, Shannon H. Romer, Sabrina Metzger, Kristiana Peraza, Matthew C. Wright, D. Scott Jobe, Long-Sheng Song, Mark M. Rich, Brent D. Foy, Robert J. Talmadge, Andrew A. Voss

Neuroscience, Cell Biology & Physiology Faculty Publications

Huntington’s disease (HD) is a fatal and progressive condition with severe debilitating motor defects and muscle weakness. Although classically recognized as a neurodegenerative disorder, there is increasing evidence of cell autonomous toxicity in skeletal muscle. We recently demonstrated that skeletal muscle fibers from the R6/2 model mouse of HD have a decrease in specific membrane capacitance, suggesting a loss of transverse tubule (t-tubule) membrane in R6/2 muscle. A previous report also indicated that Cav1.1 current was reduced in R6/2 skeletal muscle, suggesting defects in excitation–contraction (EC) coupling. Thus, we hypothesized that a loss and/or disruption of the skeletal muscle t-tubule …

Medicine And The Holocaust – My Journey Through The Course, Lauren E. Trout

Physicians and the Holocaust Student Books

This book is meant to serve as a record of my reflections throughout the Medicine in the Holocaust course, which I took during my fourth year of medical school at Wright State University Boonshoft School of Medicine, from June 2020 to May 2021. These reflections are authentic, and they answer important ethical questions authentic to who I was at the time. I hope to keep these responses to show to future generations when we discuss the Holocaust and its importance in history and to each of us.

The Wright State – Lake Campus 2020 – 2021 Scholarly Review, Wright State University - Lake Campus

Lake Campus Research Symposium Reports

This report provides a listing of the scholarly endeavors from Lake Campus during the 2020 calendar year, spanning across disciplines.

This document contains the Annual Research Report from 2020 and the Research Symposium Program from 2021.