Medicine and Health Sciences Commons^™

Able Flight At Purdue, Wesley Major, Raymart Tinio, Sarah Hubbard

International Symposium on Aviation Psychology - 2017

This paper discusses the human factors considerations associated with Able Flightat Purdue, a program that provides flight training to individualswith disabilities. The program requires a tailored approach to training due to the varied needs specific to each individual. Aircraft procedures and airfield operations are standard and all FAA regulations are followed, however, the way individuals with limited dexterity, limited hearing, or limited speech interact with the aviation system needs to be creatively approached with an open mind. The critical thinking used to address individual needs provides an excellent demonstration of problem solving that reflects human factorsconsiderations, based on the SHELL …

Innovative Airport Visual Aids To Enhance Situational Awareness And Flight Training For General Aviation, Wesley Major, Sarah Hubbard

International Symposium on Aviation Psychology - 2017

Runway incursionsare a threat to runway safety andhave been increasing in recent years. Incursions are categorized into three categories, pilot deviations (PD), operational incidents (OI), and vehicle pedestrian deviations (VPD). At general aviation airports, PDs are the most prevalent runway incursion type. Inadequate situational awareness is one of the human factors associated with PDs. Student pilots,pilots flying to an unfamiliar airport, ground operations personnel, and emergencyplanning and emergency responders can benefit from the use of visual aids that extend beyond an airport diagram or static Google Earth imagery. More robust visual aids can potentially increase situational awareness and reduce the …

Teamwork And Emergent Cognitive States As Predictors Of Routine And Adaptive Performance In Flight Dispatch Centers, Glenn E. Littlepage, Megan Wertheimer

International Symposium on Aviation Psychology - 2017

This study examines relations between the emergent cognitive state of transactive memory, the emergent affective state of collective efficacy, teamwork processes, and team performance. Mediation is examined as well as comparison of states and processes related to performance in routine and non-routine situations.

Effects Of Radar Side Conflict Probe Functionality On Atc Conflict Detection Performance And Efficiency, Anthony J. Masalonis, Ben Willems, Thomas Fincannon

International Symposium on Aviation Psychology - 2017

We investigated integrating Conflict Probe (CP) on air traffic controllers’ Radar Side (R-Side) displays. Eight controllers worked realistic, high-trafficsimulation scenarios alone, using both R-Side and Radar Associate Side (RA-Side) displays. We manipulated CP presence on the R-Side— like today,italways appeared on the RA-Side—and the presence of yellow alerts for near-conflicts. We used established controller performance and workload metrics, plus novel operational analyses not used in past studies. R-Side CP had few workload effects, but increased voice communications when we included yellow alerts. It improved the efficiency of correcting conflict-inducing clearances, and seemed to facilitate proactive control to avertmore urgent alerts. …

Predicting Tacrolimus Concentrations In Children Receiving A Heart Transplant Using A Population Pharmacokinetic Model, Joseph E. Rower, Chris Stockmann, Matthew W. Linakis, Shaun S. Kumar, Xiaoxi Liu, E. Kent Korgenski, Catherine M.T. Sherwin, Kimberly M. Molina

Pediatrics Faculty Publications

Objective Immunosuppressant therapy plays a pivotal role in transplant success and longevity. Tacrolimus, a primary immunosuppressive agent, is well known to exhibit significant pharmacological interpatient and intrapatient variability. This variability necessitates the collection of serial trough concentrations to ensure that the drug remains within therapeutic range. The objective of this study was to build a population pharmacokinetic (PK) model and use it to determine the minimum number of trough samples needed to guide the prediction of an individual’s future concentrations.

Design, setting and patients Retrospective data from 48 children who received tacrolimus as inpatients at Primary Children’s Hospital in Salt …

Irreversible Electroporation Of Locally Recurrent Pancreatic Cancer With 5-Year Survival, Alyssa Deiters, Minia Hellan, Rebecca N. Tuttle, James R. Ouellette

Department of Surgery Faculty Publications

Background: Isolated local recurrence after surgical resection for pancreatic cancer is rare. Current common therapies for recurrence include chemotherapy or chemoradiation. There are few, if any, reports regarding surgical resection of local pancreatic cancer recurrence. This is the first report of using irreversible electroporation (IRE) to treat a pancreatic adenocarcinoma local recurrence and represents a true 5-year survivor and possible cure.

Case report: A 50-year-old female initially presented with 2.5 cm mass in the uncinate process of the pancreas suspicious for malignancy. Preoperative endoscopic guided fine needle aspirate (FNA) confirmed adenocarcinoma. She underwent pylorus preserving pancreaticoduodenectomy with the finding of …

Effects Of Abstraction And Assumptions On Modeling Motoneuron Pool Output, John Michael Allen

Browse all Theses and Dissertations

Computational modeling has long been used in neuroscience as a supplement to more traditional experimental techniques, as it provides some advantages in terms of the level and detail of control available over the system being studied. At the same time, modeling has significant disadvantages by virtue of adding additional uncertainty to results and forcing the definition of potentially unclear physiological mechanisms. Nevertheless, modeling can provide useful insights when carefully defined and constrained. In this thesis, a model of the a-MN pool innervating the cat medial gastrocnemius was constructed. This model was then used to address two major questions, one regarding …

Analysis Of Stretch Reflex Responses In Mice Lacking Munc18-1 In Proprioceptors, Amr Mohi

Browse all Theses and Dissertations

The monosynaptic stretch reflex circuit is one of the simplest circuits of the central nervous system. We studied the connection between Ia proprioceptive afferents and motor neurons that comprise the circuit, by stimulating the dorsal root and recording from the ventral root of the fourth lumbar spinal nerve. In our study, we analyzed the status of neurotransmission in the stretch reflex circuit in postnatal PV-cre; munc18-1 lox/lox conditional mutant mice. Munc18-1 is responsible for synaptic vesicular release in neurons. In the PV-cre; Munc18-1 lox/lox mutants we use, Munc18-1 is only knocked out in proprioceptive afferents and A-beta somatosensory afferents, both …

Antimicrobial Activity Of Fractionated Borohydride-Capped And Electrochemical Colloidal Silver, Marjorie M. Markopoulos

Browse all Theses and Dissertations

Silver nanoparticles (AgNPs) and ionic silver (Ag+) are known to be broad-spectrum antimicrobial agents. Recent studies show these agents may be an alternative to the most widely used drinking water disinfectant, chlorine. Chlorine is a toxic industrial chemical with a lethal concentration of 430 ppm after 30 minutes. Additionally, chlorine can react with naturally occurring materials to produce a number of disinfection byproducts such as chloroform and trihalomethanes. Some of these byproducts pose cancer risks in addition to other negative impacts to human health. These would be eliminated with the use of Ag+ or AgNPs. The main goal of this …

Central Research Forum Program - 2016, Office Of Research Affairs, Boonshoft School Of Medicine

Central Research Forum

The 22-page program includes a schedule, speaker biographies, and presentation titles from the 2016 Central Research Forum held by the Boonshoft School of Medicine's Office of Research Affairs.

Flight Physician - October, 2016, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty-seven page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Department Of Surgery Update, October 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.

Neprilysin Is A Mediator Of Alternative Renin-Angiotensin-System Activation In The Murine And Human Kidney, Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C. Kaltenecker, Johannes J. Kovarik, Susan B. Gurley, Dunja Van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Jose Carlos Santos, Robson A. Santos, Khalid M. Elased, Marcus D. Säemann, Ralf A. Linker, Marko Poglitsch

Pharmacology and Toxicology Faculty Publications

Cardiovascular and renal pathologies are frequently associated with an activated renin-angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor hormone angiotensin II (Ang II). Angiotensin-converting-enzyme-2 (ACE2) has been described as a crucial enzymatic player in shifting the RAS towards its so-called alternative vasodilative and reno-protective axis by enzymatically converting Ang II to angiotensin-(1-7) (Ang-(1-7)). Yet, the relative contribution of ACE2 to Ang-(1-7) formation in vivo has not been elucidated. Mass spectrometry based quantification of angiotensin metabolites in the kidney and plasma of ACE2 KO mice surprisingly revealed an increase in Ang-(1-7), suggesting additional pathways to be responsible for …

Department Of Surgery Update, September 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.

Ptsd Symptom Severities, Interpersonal Traumas, And Benzodiazepines Are Associated With Substance-Related Problems In Trauma Patients, Jeffrey Guina, Ramzi W. Nahhas, Adam J. Goldberg, Seth Farnsworth

Population and Public Health Sciences Faculty Publications

Background: Trauma is commonly associated with substance-related problems, yet associations between specific substances and specific posttraumatic stress disorder symptoms (PTSSs) are understudied. We hypothesized that substance-related problems are associated with PTSS severities, interpersonal traumas, and benzodiazepine prescriptions. Methods: Using a cross-sectional survey methodology in a consecutive sample of adult outpatients with trauma histories (n = 472), we used logistic regression to examine substance-related problems in general (primary, confirmatory analysis), as well as alcohol, tobacco, and illicit drug problems specifically (secondary, exploratory analyses) in relation to demographics, trauma type, PTSSs, and benzodiazepine prescriptions. Results: After adjusting for multiple testing, several factors …

Department Of Surgery Update, August 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.

Reduced Motor Neuron Excitability Is An Important Contributor To Weakness In A Rat Model Of Sepsis, Paul Nardelli, Jacob A. Vincent, Randall K. Powers, Timothy C. Cope, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

The mechanisms by which sepsis triggers intensive care unit acquired weakness (ICUAW) remain unclear. We previously identified difficulty with motor unit recruitment in patients as a novel contributor to ICUAW. To study the mechanism underlying poor recruitment of motor units we used the rat cecal ligation and puncture model of sepsis. We identified striking dysfunction of alpha motor neurons during repetitive firing. Firing was more erratic, and often intermittent. Our data raised the possibility that reduced excitability of motor neurons was a significant contributor to weakness induced by sepsis. In this study we quantified the contribution of reduced motor neuron …

Acute Poisonings From Synthetic Cannabinoids — 50 U.S. Toxicology Investigators Consortium Registry Sites, 2010–2015, Anne M. Riederer, Sharan L. Campleman, Robert G. Carlson, Edward W. Boyer, Alex F. Manini, Paul M. Wax, Jeffrey A. Brent

Population and Public Health Sciences Faculty Publications

What is already known about this topic? Acute intoxications by synthetic cannabinoids appear to be increasing in the United States. Synthetic cannabinoids are two to 100 times more potent than Δ9-tetrahydrocannabinol, the active ingredient in cannabis; acute exposure is associated with a range of mild to severe neuropsychiatric, cardiovascular, renal, and other effects. What is added by this report? During 2010–2015, among 456 cases of synthetic cannabinoid intoxication among patients treated by U.S. medical toxicologists, 277 (61%) had reports of synthetic cannabinoids as the sole toxicologic agent. Three deaths were recorded, one with synthetic cannabinoids given as the sole agent …

Amaurosis Fugax Associated With Congenital Vascular Defect, John Giltner, Edward R. Thomas, William K. Rundell

Department of Surgery Faculty Publications

No abstract provided.

The Cutting Edge Summer 2016, Wright State University Department Of Surgery

The Cutting Edge Newsletter

A twelve page newsletter created by the Department of Surgery documenting current affairs of the department. This issue contains features such as faculty news, information on general surgery residencies, a list of scholarly activity, special lectures, and more.

Department Of Surgery Update, July 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.

Flight Physician - July, 2016, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty-one page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Calls To A Teratogen Information Service Regarding Potential Exposures In Pregnancy And Breastfeeding, Sarah C. Campbell, Tyler T. Kast, Julia Robertson, Catherine M.T. Sherwin

Pediatrics Faculty Publications

Background

MotherToBaby Utah is a teratogen information service that provides support for pregnant and breastfeeding women and healthcare providers regarding risks of exposures to medications, infections, herbals, homeopathic and dietary medications, chemicals and other substances. Calls are anonymous and free of charge. This study was undertaken to examine the volume and classification of calls regarding exposures during pregnancy and breastfeeding.

Methods

Data were extracted from calls requesting information about medication use and other exposures to pregnant and breastfeeding women, between January 1 2009 and December 31 2012. Descriptive statistics were calculated.

Results

A total of 27,299 calls regarding 46,031 exposures …

“When ‘Bad’ Is ‘Good’”: Identifying Personal Communication And Sentiment In Drug-Related Tweets, Raminta Daniulaityte, Lu Chen, Francois R. Lamy, Robert G. Carlson, Krishnaprasad Thirunarayan, Amit Sheth

Population and Public Health Sciences Faculty Publications

Background: To harness the full potential of social media for epidemiological surveillance of drug abuse trends, the field needs a greater level of automation in processing and analyzing social media content. Objectives: The objective of the study is to describe the development of supervised machine-learning techniques for the eDrugTrends platform to automatically classify tweets by type/source of communication (personal, official/media, retail) and sentiment (positive, negative, neutral) expressed in cannabis- and synthetic cannabinoid-related tweets. Methods: Tweets were collected using Twitter streaming Application Programming Interface and filtered through the eDrugTrends platform using keywords related to cannabis, marijuana edibles, marijuana concentrates, and synthetic …

Combining Real-Time Fmri Neurofeedback Training Of The Dlpfc With N-Back Practice Results In Neuroplastic Effects Confined To The Neurofeedback Target Region, Matthew Sherwood, Michael P. Weisend, Jessica H. Kane, Jason G. Parker

Neuroscience, Cell Biology & Physiology Faculty Publications

In traditional fMRI, individuals respond to exogenous stimuli and are naïve to the effects of the stimuli on their neural activity patterns. Changes arising in the fMRI signal are analyzed post-hoc to elucidate the spatial and temporal activation of brain regions associated with the tasks performed. The advent of real-time fMRI has enabled a new method to systematically alter brain activity across space and time using neurofeedback training (NFT), providing a new tool to study internally-driven processes such as neuroplasticity. In this work, we combined n-back practice with fMRI-NFT of the left dorsolateral prefrontal cortex (DLPFC) to better understand the …

Department Of Surgery Update, June 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A six page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.

Synapse Formation In Monosynaptic Sensory–Motor Connections Is Regulated By Presynaptic Rho Gtpase Cdc42, Fumiyasu Imai, David R. Ladle, Jennifer R. Leslie, Xin Duan, Tilat A. Rizvi, Georgianne M. Ciraolo, Yi Zheng, Yutaka Yoshida

Neuroscience, Cell Biology & Physiology Faculty Publications

Spinal reflex circuit development requires the precise regulation of axon trajectories, synaptic specificity, and synapse formation. Of these three crucial steps, the molecular mechanisms underlying synapse formation between group Ia proprioceptive sensory neurons and motor neurons is the least understood. Here, we show that the Rho GTPase Cdc42 controls synapse formation in monosynaptic sensory–motor connections in presynaptic, but not postsynaptic, neurons. In mice lacking Cdc42 in presynaptic sensory neurons, proprioceptive sensory axons appropriately reach the ventral spinal cord, but significantly fewer synapses are formed with motor neurons compared with wild-type mice. Concordantly, electrophysiological analyses show diminished EPSP amplitudes in monosynaptic …

Germline Defects Caused By Smed-Boule Rna-Interference Reveal That Egg Capsule Deposition Occurs Independently Of Fertilization, Ovulation, Mating, Or The Presence Of Gametes In Planarian Flatworms, Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana

Biological Sciences Faculty Publications

Few animals are known to lay eggs in the absence of ovulation or copulation, as it is presumably energetically wasteful and subjected to negative selection. Characterization of Smed-boule, a member of the DAZ family of germline RNA-binding proteins, revealed that egg capsule (or capsule) production and deposition occurs independently of the presence of gametes in the planarian flatworm Schmidtea mediterranea. Reduction of Smed-boule expression by RNA-interference (RNAi) causes ablation of spermatogonial stem cells and the inability of ovarian germline stem cells to undergo oogenesis. Although animals subjected to Smed-boule RNAi lose their gametes and become sterile, they continue …

Career Services Focus: Surgery, Boonshoft School Of Medicine Career Services

Department of Surgery Faculty Publications

A seven page newsletter from the Boonshoft School of Medicine's Career Services highlighting interviews with Department of Surgery faculty and students.

Department Of Surgery Update, May 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.