Medicine and Health Sciences Commons^™

Uvb Induces Mvp Release In A Paf Dependent Manner In Skin-Dervied Epithelial Cell Line, Langni Liu, Katherine E. Fahy, Christine M. Rapp, Eric J. Romer, Christina E. Borchers, Ji C. Bihl, Jeffrey B. Travers

Pharmacology and Toxicology Faculty Publications

Ultraviolet-B (UVB) irradiation of the skin can result in both acute inflammation and systemic immunosuppression. These effects are mediated by the release of bioactive molecules (e.g. cytokines and lipids) from resident skin epithelial and immune cells. Our lab has previously determined that UVB exposure stimulates the production of an inflammatory phospholipid activator, platelet-activating factor (PAF) and its oxidized analogs, which are involved in mediating the UVB responses. Due to the fact that UVB radiation is absorbed by the epidermis but causes systemic effects, we are interested in examining the PAF-mediated mechanisms of systemic intercellular communication. Microvesicle particles (MVP) are small …

Intercellular Adhesion Molecule-1 Augments Myoblast Adhesion And Fusion Through Homophilic Trans-Interactions, Francis X. Pizza, Ryan A. Martin, Evan M. Springer, Maxwell S. Leffler, Bryce R. Woelmer, Issac J. Recker, Douglas W. Leaman

Biological Sciences Faculty Publications

The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells. Hypotheses were tested using cultured myoblasts and fibroblasts, which do not constitutively express ICAM-1, and myoblasts and fibroblasts forced to express full length ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1. ICAM-1 mediated myoblast adhesion and fusion were quantified using novel assays and cell mixing experiments. We report that ICAM-1 augments myoblast adhesion to myoblasts and myotubes through homophilic trans-interactions. Such adhesive interactions enhanced levels of active Rac in adherent and …

Synaptic Up-Scaling Preserves Motor Circuit Output After Chronic, Natural Inactivity, Joseph Michael Santin, Mauricio Vallejo, Lynn K. Hartzler

Biological Sciences Faculty Publications

Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity. Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations. Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive. To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter. We found that inactive respiratory motoneurons exhibit a classic form of homeostatic plasticity, up-scaling of AMPA-glutamate receptors. Up-scaling increased the …

Insights Into The Ecology, Genetics And Distribution Of Lucanus Elaphus Fabricius (Coleoptera: Lucanidae), North America's Giant Stag Beetle, Michael D. Ulyshen, Louis G. Zachos, John O. Stireman Iii, Thomas N. Sheehan, Ryan C. Garrick

Biological Sciences Faculty Publications

1. Little is known about the biology or conservation status of Lucanus elaphus Fabricius in North America despite well-documented declines of a related species, Lucanus cervus (L.), in Europe. This study provides information critical to developing conservation plans for L. elaphus including the species’ larval substrate requirements, genetic data and range-wide estimates of habitat suitability. 2. In Mississippi floodplain forests, larval L. elaphus were recovered from a wide range of log sizes and rot types and were either found tunnelling within the wood or feeding beneath logs at the soil–wood interface. The species appears to require 1–2 years to complete …

Department Of Surgery Update, January 2017, Wright State University Department Of Surgery

Department of Surgery Updates

A one page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, and more.

Evaluation Of A Childhood Community-Based Comprehensive Asthma Management Program, Stephanie E. Welsh

Master of Public Health Program Student Publications

Background: The Dayton Children’s Hospital Comprehensive Asthma Management Program incorporates Community Health Worker (CHW) interventions to improve child asthma control and reduce urgent health resource utilization.

Methods: Children in grades two to five with parent- or physician-identified asthma received one of three levels of intervention, based on self-selection by caregivers: (1) child asthma education; (2) child and caregiver asthma education; (3) child and caregiver asthma education, plus home assessments. Child Asthma Risk Assessment Tool (CARAT) scores were collected before intervention to assess risk. Childhood Asthma Control Test (C-ACT) scores and urgent health visit numbers were collected before and after intervention. …

A Risk Factor Tool For United States Teenage Pregnancy: Adapting A Tool From The United Kingdom, Kanchen Loganathan

Master of Public Health Program Student Publications

With a population of 42 million, one out of every eight people living in the United States is an adolescent. Current data show that half of American adolescents today are engaging in sexual activity, and one in eight adolescent females will become pregnant before the age of 20. The number of teenage pregnancies have declined over the past decade due to increased contraception, and more efforts to educate adolescents on safe sex. Newer research also reports that pregnancy during an adolescent’s teenage years may not be as detrimental to their lives as once thought. However, teenage pregnancy has been linked …

The Oculometer Training Tape Technique: The Revival, Carolina Diaz-Piedra, Andres Catena, Luis J. Fuentes, Leandro L. Di Stasi

International Symposium on Aviation Psychology - 2017

The oculometer training tape technique (OT 3 ) aimsto enhance aviation training by 1) allowing theflightinstructors to provide real-time feedback, 2) improving debriefing sessions by playing back the traineepilot’s scan behavior, and 3) editing didactic videos based on the scan behavior of experienced pilots. Despite the original positive evaluations ofits usefulness, the OT 3 hasfailed to gain traction in aviation training programs. This is probably due to the technical difficulties as well as the intrusiveness/bulkiness of the equipment needed. Modern non-intrusive eye trackers,integrated witha forward facing scene-camera, can record pilots’ eye movements and, simultaneously, capture what the pilot sees. Here, …

A Dynamic System Simulation Device To Define Human-System Interface Requirements For The Dassault Rafale, Daniel Hauret, Julien Donnot

International Symposium on Aviation Psychology - 2017

Our study aimedto collect enhancement proposals of Rafale fighter aircraft human-system interface. Proposals had to be innovative and complied with the needs of information for pilots regarding Rafale future capabilities. We developed amethodology based on a device enabling the simulation of a dynamic system activity that is theRafale integrated in its war environment. Creativity of front line pilots participating inthis experimentation has been stimulated but constraint by the necessity ofa useful production due to the risks associated to the modification of a fighter aircraft already operating since 2006. Each proposal has been analyzed and synthetized through the abstraction hierarchy model …

Effects Of An Ecological Interface On Flight Training Effectiveness, Ronald Deerenberg, M.M. (René) Van Paassen, Clark Borst, Max Mulder

International Symposium on Aviation Psychology - 2017

For Ecological Interface Design (EID), the underlying constraints and properties of an operator’s work domain are analysed and used as a basis for the design of the information displays, so that these may reveal these underlying mechanisms. Most evaluations for EID have been performed with expertor trained participants. However, it can be hypothesised that the effects of EID will alsochange the way tasks are learned by novices; since the EID designs support direct manipulation, and at the same time show the constraints in the work domain, a novice would be able to performthe task as a skill, employing the direct …

Efficiency Of A Situation Awareness Training Module In Initial Pilot Training, David Gayraud, Nadine Matton, Andre Tricot

International Symposium on Aviation Psychology - 2017

Wedesigned a specific SA training module and tested whether it would enhance the SA competency of pilot trainees during initial training. Twelve pilot trainees took part to the empirical phase of the study. They were pseudo-randomly assigned to two conditions, the experimental group (n=6) who received the SA training module and the control group (n=6) who did not receive any specific SA training. All pilot trainees were assessed during a flight simulator session in order to evaluate objectively their levels of SA (SAGAT, Situation Awareness Global Assessment Technique, Endsley, 1995). Results highlighted that the SA levels …

Development Of A Model Of ‘See And Avoid’ In Parachuting, Victoria Cutler, Saskia Revell

International Symposium on Aviation Psychology - 2017

The UK military undertakes in-depth investigations of serious parachuting accidents, which have recently included two mid-air collisions. The analysis of these accidents identified that collision avoidance in parachuting uses similar processes to the see-and-avoidtask performed by aircraft pilots. However, no research was identified that had explored see-and-avoid when parachuting. Accordingly, a model of parachuting see-and-avoidwas developed which consisted of six stages which must be performed in sequence for a collision to be avoided successfully. Each stage of see-and-avoid wasassociated with key errors, the likelihood of which wasinfluenced by a range of factors within the individual, their operating environment, and equipment. …

Quantifying Pilot Contribution To Flight Safety During An In-Flight Airspeed Failure, Timothy J. Etherington, Rockwell Collins, Lynda J. Kramer, Randall E. Bailey, Kellie D. Kennedey

International Symposium on Aviation Psychology - 2017

Accident statistics cite the flight crew as a causal factor in over 60% of large transport fatal accidents. Yet a well-trained and well-qualified crew is acknowledged as the critical center point of aircraft systemssafety and an integral component of the entire commercial aviation system. A human-in-the-loop test was conducted using a Level D certifiedBoeing 737-800 simulator to evaluate the pilot’s contribution to safety-of-flight during routine air carrier flightoperations and in response to system failures. To quantify the human’s contribution, crew complement was used as an independent variable in a between-subjects design. This paper details the crew’s actions and responses while …

Federal Aviation Administration Flight Deck Human Factors Research Program, Sheryl L. Chappell, Regina G. Bolinger, Ashley C. Awwad

International Symposium on Aviation Psychology - 2017

The next generation air transportation system (NextGen) is a comprehensive suite of state-of-the-art technologies and procedures that improves national airspace system(NAS)capacity and efficiency, while maintaining world-class safety. In order to realize these improvements,the roles and the systems ofpilots and controllers are changing. Advanced technologies and new procedures make the information and the tasksmore complex. The Federal Aviation Administration’s (FAA) Flight Deck Human Factors Research Programexamines flightcrew interaction with current and future technology and pilotperformance of flight procedures. Human factors scientists across industry, government,and academia produce scientific and technical data-driven recommendationsto support the FAA’s development of regulatory standards, policies, and other …

Self-Deception And Impression Management In Commercial Pilots: An Underreported And Potential Confound In Aviation Research, Tabitha T. Black, Ryan Sain, Steven M. Vera

International Symposium on Aviation Psychology - 2017

A concern when administering questionnaires is whether the participant is providing information that is accurate. The Balanced Inventory of Desirable Responding(BIDR) was used to assess commercial pilots’ socially desirable responding resulting in two profiles: Impression management (IM; faking bad) and self-deceptive enhancement (SDE; faking good). These pilots’ profiles were compared to the Aviation Safety Locus of Control(ASLOC) scale, used to measure external (ASLOC-E) or internal (ASLOC-I)orientation, and the Crew Resource Management Training Survey(CRMTS)developed from the Federal Aviation Administration’s guidelines for CRM. The results from the SDE indicated that over a fourth of the participants responded in a …

Sms Hazard Analysis At A University Flight School, Don Crews, Wendy Beckman

International Symposium on Aviation Psychology - 2017

For the last several years, the flight school of a mid-sizeduniversity has been working to implement a safety management system (SMS). As part of the effort, a robust self-reporting system has been developed, from which data has been used to effect changes in school policies and procedures. In thisproject, the safety reports that have accumulated over the life of the reporting systemwere classified based on the hazards experiencedwhich caused the report generation.Non-use of standard procedures was found to be theleading hazard, with 90 of the 176 reports indicating improper procedure application. The traffic pattern at the non-towered airport wherethe flight …

Self-Leadership Strategies & Performance Perspectives Within Student Aviation Teams, Christopher Ryan Bearden

International Symposium on Aviation Psychology - 2017

Thisstudy uses a correlational-design to explore relationships betweenpeer ratings of team member effectiveness, supervisor ratings of performance, and self-reportedperformancestrategiesassociated with self-leadership.Team members that were perceived as effective by their peers were also favorably rated on job performance by their supervisors. Peer-ratings onpossession of job-relevant knowledge, skills, and abilitiesincreased with frequency of communication behaviors, as rated by supervisors.This finding replicates previous research that suggests talking leads to perceived expertise in teams.Finally, self-goal setting was found to be related to peer-rated teammate effectiveness, but not supervisor-rated performance.

Individual Pilot Factors Predict Diversion Management During A Simulated Cross- Country Vfr Flight, Kathleen Van Benthem Ph.D., Chris M. Herdman Ph.D.

International Symposium on Aviation Psychology - 2017

The risk of an accident during general aviation (GA) flight increases when pilots are required to make unexpected diversions. Specifically, a diversion may result in loss of situation awareness (SA). Loss of SA is associated with controlled flight into terrain,incorrect trajectory for orbiting or landing, or becoming lost en route. In the present study, 44 GA pilots (aged 41 to 74 years) flew a cross-country route in a Cessna 172 simulator and encountered an unexpected diversion to an alternate aerodrome. The outcome measure consisted of a diversion management score. Significant predictors of diversion management were pilot age and license, a …

Transparency And Conflict Resolution Automation Reliability In Air Trffic Control, Fitri Trapsilawati, Christopher Wickens, Chun-Hsien Chen, Xingda Qu

International Symposium on Aviation Psychology - 2017

This paper investigates the automation reliability and the transparency in automation conflict resolutionadvisories for air traffic control. Fourgeneral effects: those of traffic load, those of expertise and,those of imperfect automationand its mitigation by automation transparencyin the context of the lumberjack analogywere examined. The results showed that the two automation functions, theconflict resolution advisor (CRA)and thevertical situation display (VSD) offer benefits for both novice andprofessional controllers’s performance and increased situation awarenessacross traffic loads, even when the former is of imperfect reliability.

Effects On Task Performance And Psychophysiological Measures Of Performance During Normobaric Hypoxia Exposure, Chad Stephens, Kellie Kennedy, Nicholas Napoli, Matthew Demas, Laura Barnes, Brenda Crook, Ralph Williams, Mary Carolyn Last, Paul Schutte

International Symposium on Aviation Psychology - 2017

Human-autonomous systems have the potential to mitigate pilot cognitive impairment and improve aviation safety.A research team at NASA Langley conducted an experiment to study the impact of mild normobaric hypoxia induction on aircraft pilot performance and psychophysiological state. A within-subjects design involved non-hypoxic and hypoxic exposures while performing three 10-minute tasks.Results indicated the effect of 15,000 feet simulated altitude did not induce significant performance decrementbut did produce increasein perceived workload. Analyses of psychophysiological responses evince the potential of biomarkers for hypoxia onset. This study represents on-going work at NASA intending to add to the current knowledge of psychophysiologically-based input to …

Warhorse: A New Approach To Manned/Unmanned Teaming, Paul Schutte, Ralph Williams, Ronald Daiker

International Symposium on Aviation Psychology - 2017

This paper presents a multi-human/multi-vehicle control and integration concept called Warhorse. Warhorse is a control paradigm that is applied to all vehicles (air or ground) that are used in conducting operations. The Warhorse concept aids humans in developing operational plans, enacting a plan using single or multiple vehicles (manned and/or unmanned), and individually controlling a single vehicle (i.e., one-on-one). It synergistically integrates the human with the machine so that the warfighter can bring all their skills and experience to bear on accomplishing the mission.

Task Analysis Of Two Crew Operations In The Flight Deck: Investigating The Feasibility Of Using Single Pilot, Paul Schutte

International Symposium on Aviation Psychology - 2017

This paper describes a task analysis of two crew operations in the flight deck in Part 121 Operations from gate to gate on a cross country flight. In addition, several non-normal scenarios wereanalyzed. Literature and operations materials werecombined to develop the task lists. A primary source for this study is“An Exploration of Function Analysis and Function Allocation in the Commercial Flight Domain” by McGuire, et. al. (1991). Once the tasks wereidentified, they wereset to an actually flight time schedule. Each task wasassigned to either the Pilot Flying(PF) or the Pilot Monitoring (PM) in today’s operations. Additionally, tasks werecategorized as: discrete …

Human-Machine Articulation Work: Functional Dependency Dialogue For Human-Machine Teaming, Clayton D. Rothwell, Valerie L. Shalin

International Symposium on Aviation Psychology - 2017

Articulation work is an overlooked requirement for successful human-machine teams. Articulation work captures the often hidden task management activities human-human teams regularly perform in response to functional dependencies amongst team members. While human-human teams demonstrate articulation work through language, human-machine teams currently do not. Aviation is replete with examples, from the superficially mundane adaptation inherent in the turnaround of commercial aircraft to the life-threatening misunderstanding in Turkish Airlines Flight 1951 and Asiana Flight 214. Current research in human-machine language-mediated interaction has failed to study tasks that are sufficiently complicated to require articulation work, resulting in a misleading optimism about the …

A Comparison Of Helmet-Mounted Display Symbologies During Live Flight Operational Tasks, Thomas Schnell, Christopher Reichlen, Christopher Reuter, Eric Geiselman, Jonathan Knox, Henry Williams

International Symposium on Aviation Psychology - 2017

Spatial disorientation continues to be one of the most costly problems in military aviation, as measured by both life and equipment loss. The unique Helmet-Mounted Display (HMD) centric interface within 5 th generation aircraft has the potential to increase tactical capabilitywhen compared toprevious similar-role aircraft.This study investigated the addition of off-axis ownship attitude information within the HMD field-of-view when the operator looksaway from the virtual Head-Up Display (vHUD). In some 5 th generation aircraft, traditional HUD symbology is presented via the HMD as there is no aircraft-fixed combiner. In some instances, the only attitude information included via the HMD is …

Application Of Big Data Systems To Aviation And Aerospace Fields; Pertinent Human Factors Considerations, Chang-Guen Oh

International Symposium on Aviation Psychology - 2017

The aviation and aerospacearetypical areas that can apply big data systems due to theirscales. This paper identifies aviation/aerospaceareas that canutilize big data infrastructures to enhance their operational performances, and lightens human factors considerations related to the use of big data. The NextGen’s network-centric infrastructure defines sharing a huge amount of aeronautics, flight, and weather dataunder the system wide information management program. Sensors installed on aircraft components extract huge numbers of aircraft health and operational status data.All professionals who work in the different aviation sectorsrequire this shared situational awareness information for their own distinctive purposes, and big data systems will enable …

Cognitive Ergonomics And Knowledge Management: A New Model Of Addressing Aviation Issues, Ronald John Lofaro

International Symposium on Aviation Psychology - 2017

The field of cognitive/knowledge engineering (CE/KE) has expanded to encompassa subset called knowledge management (KM).The main difference between KM and KE isthat the knowledge manager establishes the direction the process should take, whereas the knowledge engineer develops the means to accomplish that direction. Cognitive Ergonomics, also a discipline within CE/KE, deals with decision-making, skilled performance(s) and trainingwith a focus onthe fit between human cognitive abilities/limitations and selected task(s)... all areasvital to aviation. This paper will briefly showthe components and processes of anew model for decision-making usingall these disciplines andPareto analysis in a blended Delphi, beginning with a small group delphi …

Status Of Faa Air Traffic Control Fatigue Interventions 2013-2016, Darendia Mccauley

International Symposium on Aviation Psychology - 2017

The Federal Aviation Administration (FAA) has long been concerned with the impact of fatigue in Air Traffic Operations. Fatigue has been cited as a factor in operational incidents. The shift work and quick turn-around shifts contribute to this problem. In conjunction with the collective bargaining agreement, FAA management and the National Air Traffic Association (NATCA) agreed to jointly develop a series of interventions designed to mitigate some of the aspects of fatigue in the controller workforce. This resulted in a Fatigue Group comprised of FAA management, NATCA representatives, and fatigue scientists. Following 15 work-intensive meetings, the Fatigue Risk Management Group …

Four-Year Follow-Up Of Intensive, Simulator-Based Pilot Training, Maxine Lubner Ph.D., Deb Henneberry M.A., Sharon Devivo Ed.D., Andrew R. Dattel Ph.D., Emerson Allen B.S.

International Symposium on Aviation Psychology - 2017

Sixteen students, who began with 0-20 flight hours, enrolled in an intensive, simulator based, collegiate training program. They completed their training with fewer flight hours than the US average: FAA Private Pilot within 4-6 weeks; instrument ratings in 3-4 weeks; Commercial within an average of 20 weeks and CFI ratings in an average of 40 weeks and all graduated with Bachelor’s degrees (ISAP, 2013). The students had met selection criteria. At the time, indicators of success included variables associatedwith simulator based training, camaraderie, shared learning and opportunities to reflect on training. Four years later, 81% are now flying professionally: eight …

How Automation May Transform The Ways In Which Crew Manage Peak Workload And Incapacitation, Nick Mcdonald, Alison Kay, Rabea Morrison, Margaret Ryan

International Symposium on Aviation Psychology - 2017

A ‘Crew Manage the Operation’ concept was developed as a unifying framework to analysethe combined role of diverse technologies in supporting the management of peak workload and incapacitation. Multiple-crew configurations meanthat many of the same technologies are supporting quite contrasting instantiation of crew roles. While Proactive and Immediate modes support the independence of the crew in their cockpit, both reactive modes of workload management pose questions about the information flow between the cockpit and ground control, and in turn about the level of support or, in the final mode, effective interventionthat could be provided from the ground. These issues are …

Development Of Increasingly Autonomous Traffic Data Manager Using Pilot Relevancy And Ranking Data, Lisa R. Le Vie, Vincent E. Houston

International Symposium on Aviation Psychology - 2017

NASA’s Safe Autonomous Systems Operations (SASO) project goal is to define and safely enable all future airspace operations by justifiable and optimal autonomy for advanced air, ground, and connected capabilities. This work showcases how Increasingly Autonomous Systems (IAS) could create operational transformations beneficial to the enhancement of civil aviationsafety and efficiency. One such IAS under development is the Traffic Data Manager (TDM). This concept is a prototype ‘intelligent party-line’ system that would declutter and parse out non-relevant air traffic, displaying only relevant air traffic to the aircrewin a digital data communications (DataComm) environment. As an initial step, over 22,000 data …