Medicine and Health Sciences Commons^™

Bovine Tuberculosis In Michigan White-Tailed Deer

Zoonotics and Wildlife Disease: Publications

Starting in 1995 hunter harvested, road killed, and other dead deer were examined for bovine TB infection. White-tailed deer in Michigan have since been tested year round for bovine TB. Testing revealed that most of the TB positive animals were located in a core area in the northeastern part of Michigan's Lower Peninsula. The core area is located around the four corners where the counties of Montmorency, Alpena, Oscoda and Alcona meet. Antrim, Crawford, Emmet, Iosco, Mecosta, Osceola, Otsego, Presque Isle, and Roscommon Counties have also had animals test positive for bovine TB.

In the U.S. today, the threat of …

Modified Amino Acid Copolymers Suppress Myelin Basic Protein 85–99-Induced Encephalomyelitis In Humanized Mice Through Different Effects On T Cells, Zsolt Illés, Joel N.H. Stern, Jay Reddy, Hanspeter Waldner, Marcin P. Mycko, Celia F. Brosnan, Stephan Ellmerich, Daniel M. Altmann, Laura Santambrogio, Jack L. Strominger, Vijay K. Kuchroo

Jay Reddy Publications

A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) pro- tein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85–99-specific HLA-DR2-restricted T cell receptor from an MS patient has been used to examine the effectiveness of modified amino acid copolymers poly(F,Y,A,K)n and poly- (V,W,A,K)n in therapy of MBP 85–99-induced experimental auto-immune encephalomyelitis (EAE) in comparison to Copolymer 1 [Copaxone, poly(Y,E,A,K)n]. The copolymers were designed to optimize binding to HLA-DR2. Vaccination, prevention, and treatment of MBP-induced EAE in the humanized mice with copolymers FYAK and VWAK ameliorated EAE more effectively than Copolymer 1, reduced the number of pathological lesions, and …

Attachment And Depression Differentially Influence Nicotine Dependence Among Male And Female Undergraduates: A Preliminary Study, Dennis E. Mcchargue, Lee M. Cohen, Jessica W. Cook

Department of Psychology: Faculty Publications

The authors surveyed a convenience sample of 208 undergraduate students who reported that they smoked cigarettes. The primary hypothesis they tested was whether gender predicted nicotine dependence. They further tested whether depression and attachment would mediate or moderate this relationship. Hierarchical regression analyses with social desirability and smoking stage of change entered as covariates indicated that women exhibited greater nicotine dependence than men did (p < .01). Lower attachment scores fully mediated this relationship, whereas elevated depression scores moderated the relationship. These findings suggest that depression and the inability to bond with peers may promote nicotine dependence among young female students.

Impulsivity And Smoking Relapse, Neal Doran, Bonnie Spring, Dennis E. Mcchargue, Michele Pergadia, Malia Richmond

Department of Psychology: Faculty Publications

Previous research has shown that elevated trait-impulsivity heightens the risk for initiating tobacco use and indicates that nicotine may be disproportionately rewarding for more impulsive persons. However, the influence of impulsivity on the ability to maintain nicotine abstinence has not been studied. The present study tested the hypothesis that a higher level of trait-impulsivity would predict a more rapid relapse to smoking following 48 hr of nicotine abstinence. Participants were euthymic, regular smokers (N=45), with a history of at least one major depressive episode, who participated in a paid smoking cessation study with biological challenge (tryptophan depletion). Treatment …

Letter To The Editor: Response To Covey, Brian Hitsman, Bonnie Spring, Belinda Borrelli, Dennis E. Mcchargue, Raymond Niaura

Department of Psychology: Faculty Publications

Dr. Covey asserts that our meta-analysis of the association between history of major depression and smoking treatment outcome (Hitsman, Borrelli, McChargue, Spring, & Niaura, 2003) was flawed because we did not limit our analysis to participants randomized to placebo or alternative least intensive treatment condition.

Salmonella In Songbirds

Zoonotics and Wildlife Disease: Publications

Salmonella is a type of bacterium found in the gut of many species of birds both domestic and wild. During periods of stress it can cause outbreaks of sickness and death. Its importance in songbird populations generally and the occurrence of outbreaks in this province specifically are discussed in this fact sheet.

Parasites Of Caribou (1): Brain Worm Infestation

Zoonotics and Wildlife Disease: Publications

Brain worm is the common name for a disease of caribou that was first recognized in Central Newfoundland in the 1970's and has since been seen in other caribou herds including most recently the caribou of the Southern Avalon. Its more scientific name is Cerebrospinal Elaphostrongylosis (CSE) and is caused by the nematode Elaphostrongylus rangiferi.
Infection can cause severe illness and death in affected animals and has a particularly strong impact on herds that have not been previously exposed to this parasite.
As this is primarily a disease of caribou, there is no direct public health threat to humans. Moose …

Parasites Of Caribou (2): Fly Larvae Infestations

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern if they can spread to humans or domestic animals. In other cases they might be of interest if they impact on the health of our wild herds, or simply because the signs of the disease have been noticed and you want to know more.
This fact sheet is one of a series produced on the common diseases of caribou and covers the larval form of two different flies commonly seen in this province. Neither of these are a cause of public health concern.

Parasites Of Caribou (3): Tapeworm Cysts

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern if they can spread to humans or domestic animals. In other cases, they might be of interest if they impact on the health of our wild herds, or simply if they have been noticed by hunters and you would like to know more.
This fact sheet is one of a series produced on the common diseases of caribou and covers the cyst form of three common tapeworms. Two (Taenia hydatigena and Taenia krabbei) exist on both the island of Newfoundland and in Labrador, while the …

Pesticide Poisoning Of Seagulls

Zoonotics and Wildlife Disease: Publications

In April 2000 a major pesticide leak caused the death and illness of a significant number of wild birds. The findings and conclusions of this die-off are detailed.

Parasites Of The Snowshoe Hare (1): Tapeworm Cysts

Zoonotics and Wildlife Disease: Publications

All wild animals carry diseases. In some cases these might be of concern because they can spread to humans or domestic animals. In other cases they may be of interest simply because the signs of the disease have been seen and you want to know more. Though diseases are relatively common in these animals there is usually an increase in reporting when the hare populations are at a peak. High populations mean that there is an increased chance of one animal infecting another. In addition, when there are too many animals in one area, the amount of available food is …

Keep Your Cabin Free Of Rodents

Zoonotics and Wildlife Disease: Publications

Cabins that have been closed for the winter can become nesting sites for mice, shrews and other rodents. These animals can carry fleas, ticks, viruses or other organisms on their skin, in their droppings or urine. These can cause diseases in humans, especially when you breathe in the dust from their droppings or nesting sites.
Avoid close contact with rodent urine, droppings, nesting materials or with any food or surfaces contaminated with them.
Always wear rubber gloves when handling dead rodents, or when cleaning traps, droppings, nesting sites or other areas that rodents may have visited.

Lyme Disease In Newfoundland

Zoonotics and Wildlife Disease: Publications

Lyme Disease, spread by ticks, is an illness affecting both humans and domestic animals. The presence of the bacteria causing this illness was reported for the first time in this province in July 2001. This fact sheet provides details on the disease and its spread.

Flash Artifact Suppression In Two-Dimensional Ultrasound Imaging, Richard Yung Chiao, Gregory Ray Bashford, Mark Peter Feilen, Cynthia Andrews Owen

Biomedical Imaging and Biosignal Analysis Laboratory

Flash artifacts in ultrasound flow images are suppressed to achieve enhanced flow discrimination. Flash artifacts typically occur as region of elevated signal strength (brightness or equivalent color) within an image. A flash suppression algorithm included the steps of estimating the flash within an image and then suppressing the estimated flash. The mechanism for flash suppression is spatial filtering. An extension of this basic method used information from adjacent frames to estimate the flash and/or to smooth the resulting image sequence. Temporal information from adjacent frames is used as an adjunct to improve performance.

Annual Report To The Nation On The Status Of Cancer, 1975–2001, With A Special Feature Regarding Survival, Ahmedin Jemal, Limin X. Clegg, Elizabeth Ward, Lynn A. G. Ries, Xiao-Cheng Wu, Patricia Jamison, Phyllis A. Wingo, Holly L. Howe, Robert N. Anderson, Brenda K. Edwards

United States Public Health Resources

BACKGROUND. The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updated information regarding cancer occurrence and trends in the U.S. This year’s report features a special section on cancer survival.

METHODS. Information concerning cancer cases was obtained from the NCI, CDC, and NAACCR and information concerning recorded cancer deaths was obtained from the CDC. The authors evaluated trends in age-adjusted cancer incidence and death rates by regression models and described and compared survival rates over …

Relative Importance Of Heat-Labile Enterotoxin In The Causation Of Severe Diarrheal Disease In The Gnotobiotic Piglet Model By A Strain Of Enterotoxigenic Escherichia Coli That Produces Multiple Enterotoxins, Emil M. Berberov, You Zhou, David H. Francis, Michael A. Scott, Stephen D. Kachman, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) strains that produce multiple enterotoxins are important causes of severe dehydrating diarrhea in human beings and animals, but the relative importance of these enterotoxins in the pathogenesis is poorly understood. Gnotobiotic piglets were used to study the importance of heat-labile enterotoxin (LT) in infection with an ETEC strain that produces multiple enterotoxins. LT^- (ΔeltAB) and complemented mutants of an F4⁺ LT⁺ STb⁺ EAST1⁺ ETEC strain were constructed, and the virulence of these strains was compared in gnotobiotic piglets expressing receptors for F4⁺ fimbria. Sixty percent of the piglets …

Gender And Age Differences In Brazilian Children’S Friendship Nominations And Peer Sociometric Ratings, Maria Rosario De Guzman, Gustavo Carlo, Lenna L. Ontai, Silvia H. Koller, George P. Knight

Department of Psychology: Faculty Publications

The purpose of this study was to examine gender-and age-related patterns of friendship preferences among Brazilian children. In particular, we examined: (a) children’s same-sex friendship preference, and its greater intensity among older children; (b) higher exclusivity among girls and higher inclusiveness among boys; and (c) generally higher exclusivity and inclusiveness among older children. Participants were 210 (110 boys, 100 girls) public school students from Brazil who ranged in age from 3.0 to 10.5 years of age. Children were asked to nominate their best friends and to rate how much they liked and disliked each of their other classmates. Children generally …

Reinforcement Expectations Explain The Relationship Between Depressive History And Smoking Status In College Students, Dennis E. Mcchargue, Bonnie Spring, Jessica Werth Cook, Christopher A. Neumann

Department of Psychology: Faculty Publications

Little is understood about biobehavioral mechanisms that mediate the comorbidity between cigarette smoking and depression. We hypothesized that expectancies about nicotine’s reinforcing effects are associated with vulnerability to depression, and may partially explain the relationship between history of depression and smoking. Young adult smokers and never smokers (N = 175, mean age = 19.9 years, S.D. = 3.2) were assessed for history of depression and expectations about the negative (e.g., dispels bad moods) and positive (e.g., increases pleasure) reinforcing effects of smoking. Results are inconsistent with the premise that negative reinforcement expectancies mediate the comorbidity between depression and nicotine …

Problem Behavior Theory: An Examination Of The Behavior Structure System In Latino And Non-Latino College Students, Byron L. Zamboanga, Gustavo Carlo, Marcela Raffaelli

Department of Psychology: Faculty Publications

Scholars have proposed that diverse problem and conventional behaviors reflect a single underlying factor; however, others suggest that the strength and pattern of interrelations among problem and conventional behaviors are not consistent across different cultural groups. The present study investigated the factor structure of problem and conventional behaviors in Cuban, non-Cuban Latino, and non-Latino college students. Two hundred and sixty-nine college students (70% women; M age=19.0, SD=2.34) reported on their substance use, and involvement in deviant (e.g., fighting, shoplifting, vandalism) and conventional (e.g., school performance, religiosity) behaviors. In support of the behavior system of Problem Behavior Theory (PBT), a single-common …

Hantavirus In Deer Mice

Zoonotics and Wildlife Disease: Publications

Hantaviruses are a group of viruses recently identified in North America as being a risk for human health. The importance of these viruses and the facts on their presence in Newfoundland are discussed.

Michigan Bovine Tuberculosis Eradication Project: 2004 Activities Report And Conference Proceedings

Michigan Bovine Tuberculosis Bibliography and Database

On June 9 and 10, 2004, the State of Michigan and U.S. Department of Agriculture hosted the eighth annual Bovine Tuberculosis (TB) Conference, with guest speakers from Georgia, Colorado, Iowa, New York and two Canadian provinces. Our guests came together from across North America to receive policy updates and share the latest scientific data and innovative research on bovine TB.

Among other things, the speakers shared insight on: the promotion of biosecurity; the $30 million annual costs of TB eradication in New Zealand; the latest research in new and improved blood tests; and the first season results of the Michigan …

Ileocolitis Associated With Anaerobiospirillum In Cats, H. E. V. De Cock, S. L. Marks, B. A. Stacy, T. S. Zabka, J. Burkitt, G. Lu, David J. Steffen, Gerald E. Duhamel

School of Veterinary and Biomedical Sciences: Faculty Publications

Ileocolitis associated with spiral bacteria identified as an Anaerobiospirillum sp. was found in six cats. Two cats had acute onset of gastrointestinal signs characterized by vomiting and diarrhea in one cat and vomiting in another cat, one cat had chronic diarrhea that was refractory to medical therapy; one cat had acute onset of anorexia and lethargy, and two cats had clinical signs that were not related to the gastrointestinal tract. The presence of an Anaerobiospirillum sp. was demonstrated on the basis of ultrastructural morphology of spiral bacteria associated with intestinal lesions and PCR amplification of a genus-specific 16S rRNA gene …

Rabies In Newfoundland & Labrador

Zoonotics and Wildlife Disease: Publications

Rabies is a deadly viral disease of the brain spread by the bite of infected mammals. It is most commonly seen in red or arctic foxes in this province though other wild animals such as bats may carry the disease. Sick foxes can bite other foxes, dogs, cats, wolves, caribou, other animals and people and make them sick. Once bitten by an animal with rabies it can take from two weeks to six months before the animal shows signs of the disease. Though uncommon, this period can be as short as 4 days or as long as a year or …

Identification Of A Novel Bovine Herpesvirus 1 Transcript Containing A Small Open Reading Frame That Is Expressed In Trigeminal Ganglia Of Latently Infected Cattle, Melissa Inman, Joe Zhou, Heather Webb, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine herpesvirus 1 (BHV-1), like other Alphaherpesvirinae subfamily members, establishes latency in sensory neurons. The latency-related (LR) RNA is abundantly expressed during latency, and expression of an LR protein is required for the latency reactivation cycle in cattle. Within LR promoter sequences, a 135-aminoacid open reading frame (ORF) was identified, ORF-E, that is antisense to the LR RNA. ORF-E is also downstream of the gene encoding the major viral transcriptional activator, bICP0. Strand-specific reverse transcription-PCR demonstrated that a transcript containing ORF-E was consistently expressed in trigeminal ganglia (TG) of latently infected calves, productively infected cultured cells, and acutely infected calves. …

Extending The Revelation Effect To Faces: Haven’T We Met Before?, Brian H. Bornstein, Jeffrey R. Wilson

Department of Psychology: Faculty Publications

The revelation effect is an episodic memory phenomenon where participants are more likely to report that they recognized an item when it is judged after an interpolated task than when it is not. Although this effect is very robust, nearly all of the extant research has used verbal or readily verbalizable stimuli. The present two experiments examined whether a revelation effect could be produced with non-verbal stimuli such as faces. A revelation effect was found in both experiments, for both targets and lures, using faces as stimuli. The findings are integrated into the prevailing empirical frameworks for the revelation effect …

Influenza Vaccination Coverage Among Adults With Asthma: Findings From The 2000 Behavioral Risk Factor Surveillance System, Earl S. Ford, Seymour G. Williams, David M. Mannino, Stephen C. Redd

United States Public Health Resources

The prevalence of asthma has increased substantially in the United States since 1980 (1). The primary clinical and public health strategy to reduce the burden of asthma is to prevent exacerbation of the disease, of which upper and lower respiratory tract infections are a major cause (2–5). One such infection—influenza— and its complications are potentially preventable with annual vaccination, which is a safe and effective method (6,7), including among persons with asthma (8). Because persons with asthma are at increased risk of complications from influenza, they are advised to receive annual influenza vaccinations (9), unless there are contraindications.
Little is …

“French Heartworm” Infection Of Dogs & Foxes In Newfoundland

Zoonotics and Wildlife Disease: Publications

French Heartworm is the common name for a parasitic disease affecting foxes, dogs, and other members of the dog family. Caused by the nematode (worm) Angiostrongylus vasorum, this disease was first thought to exist in France in the mid 1800's. It is now considered to exist generally in Europe but has not been reported in North America other than on the Island of Newfoundland, with the exception of infected animals imported from Europe but diagnosed in North America. The first case recorded in Newfoundland was in Aquaforte (Avalon Peninsula) in 1973.
When and how it might have come over …

Seroprevalence Of Bartonella Infection In American Free-Ranging And Captive Pumas (Felis Concolor) And Bobcats (Lynx Rufus), Bruno B. Chomel, Yoko Kikuchi, Janice S. Martenson, Melodie E. Roelke-Parker, Chao-Chin Chang, Rickie W. Kasten, Janet E. Foley, John Laudre, Kerry Murphy, Pamela K. Swift, Vicki L. Kramer, Stephen J. O'Brien

Zoonotics and Wildlife Disease: Publications

Bartonella henselae is the main agent of cat scratch disease in humans and domestic cats are the main reservoir of this bacterium. We conducted a serosurvey to investigate the role of American wild felids as a potential reservoir of Bartonella species. A total of 479 samples (439 serum samples and 40 Nobuto strips) collected between 1984 and 1999 from pumas (Felis concolor) and 91 samples (58 serum samples and 33 Nobuto strips) collected from bobcats (Lynx rufus) in North America, Central America and South America were screened for B. henselae antibodies. The overall prevalence of B. …

The Influence Of Personality And Affect On Nicotine Dependence Among Male College Students, Dennis E. Mcchargue, Lee M. Cohen, Jessica Warth Cook

Department of Psychology: Faculty Publications

Many clinicians and researchers hypothesize that tobacco use disorders, regardless of the route of administration, are maintained by the ability of nicotine to regulate positive and negative mood states. The present study (N = 137) examined whether certain mood states predicted dependence on either cigarettes or smokeless tobacco and whether specific personality characteristics (e.g., extraversion, neuroticism, and psychoticism) mediated these relationships among young male college students. Results indicated that positive and negative moods predicted cigarette dependence (p values = .01) and that neuroticism partially mediated the relationship between positive affect and cigarette dependence. Exploratory analyses revealed that positive …

Chronic Wasting Disease—Prion Disease In The Wild, Steve Bunk

Zoonotics and Wildlife Disease: Publications

In 1967, mule deer in a research facility near Fort Collins, Colorado, in the United States apparently began to react badly to their captivity. At least, that was the guess of researchers working on the natural history and nutrition of the deer, which became listless and showed signs of depressed mood, hanging their heads and lowering their ears. They lost appetite and weight. Then they died—of emaciation, pneumonia, and other complications—or were euthanized. The scientists dubbed it chronic wasting disease (CWD), and for years they thought it might be caused by stress, nutritional deficiencies, or poisoning. A decade later, CWD …