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Articles 3961 - 3990 of 5204

Full-Text Articles in Medicine and Health Sciences

West Nile Virus Blood Transfusion-Related Infection Despite Nucleic Acid Testing, Alexandre Macedo De Oliveira, Brady D. Beecham, Susan P. Montgomery, Robert S. Lanciotti, Jeffrey M. Linnen, Cristina Giachetti, Larry A. Pietrelli, Susan L. Stramer, Thomas J. Safranek Dec 2004

West Nile Virus Blood Transfusion-Related Infection Despite Nucleic Acid Testing, Alexandre Macedo De Oliveira, Brady D. Beecham, Susan P. Montgomery, Robert S. Lanciotti, Jeffrey M. Linnen, Cristina Giachetti, Larry A. Pietrelli, Susan L. Stramer, Thomas J. Safranek

United States Public Health Resources

BACKGROUND: A case of West Nile virus (WNV) encephalitis associated with transfusion of blood that did not react when tested for WNV by minipool (MP) nucleic acid testing (NAT) is described. A Nebraska man developed clinical encephalitis 13 days after surgery and transfusion of 26 blood components. Antibody testing confirmed WNV infection. An investigation was initiated to determine the source of this infection.
STUDY DESIGN AND METHODS: The patient’s family members were interviewed to identify risk factors for WNV infection. Residual samples were retested for WNV RNA using transcription-mediated amplification (TMA) assay and two polymerase chain reaction (PCR) assays. Blood …

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Influence Of Fluoxetine On Positive And Negative Affect In A Clinic-Based Smoking Cessation Trial, Jessica Werth Cook, Bonnie Spring, Dennis E. Mcchargue, Belinda Borrelli, Brian Hitsman, Raymond Niaura, Nancy J. Keuthen, Jean Kristeller Dec 2004

Influence Of Fluoxetine On Positive And Negative Affect In A Clinic-Based Smoking Cessation Trial, Jessica Werth Cook, Bonnie Spring, Dennis E. Mcchargue, Belinda Borrelli, Brian Hitsman, Raymond Niaura, Nancy J. Keuthen, Jean Kristeller

Department of Psychology: Faculty Publications

Rationale – Fluoxetine improves affect in clinical syndromes such as depression and premenstrual dysphoric disorder. Little is known about fluoxetine’s influence on mood changes after quitting smoking, which often resemble sub-clinical depression. Objectives – The present study, a re-analysis of previously published data (Niaura et al. 2002), examined fluoxetine’s effect on changes in negative and positive affect following quitting smoking. Methods – Adult smokers (n = 175) without clinically significant depression were randomized on a double-blind basis to receive fluoxetine hydrochloride (30 or 60 mg daily) or placebo for 10 weeks in combination with cognitive-behavioral therapy (CBT) for smoking cessation. …

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Religiosity, Values, And Horizontal And Vertical Individualism-Collectivism: A Study Of Turkey, The United States, And The Philippines, Cem Safak Cukur, Maria Rosario De Guzman, Gustavo Carlo Dec 2004

Religiosity, Values, And Horizontal And Vertical Individualism-Collectivism: A Study Of Turkey, The United States, And The Philippines, Cem Safak Cukur, Maria Rosario De Guzman, Gustavo Carlo

Department of Psychology: Faculty Publications

The authors examined the links between two dimensions that have been useful in understanding cross-cultural differences and similarities, namely, individualism- collectivism (I-C) and value orientations. The authors examined the relations and parallels between the two variables by directly relating them and examining the patterns of relations that both have with a third variable, religiosity. Participants were 475 college students from the Philippines, the United States, and Turkey who responded to measures of horizontal and vertical I-C, value orientations, and religiosity. The authors found partial support for the parallels between I-C and value types, particularly for collectivism and conservative values. Moreover, …

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Pathways To Self-Esteem In Late Adolescence: The Role Of Parent And Peer Attachment, Empathy, And Social Behaviors, Deborah J. Laible, Gustavo Carlo, Scott C. Roesch Dec 2004

Pathways To Self-Esteem In Late Adolescence: The Role Of Parent And Peer Attachment, Empathy, And Social Behaviors, Deborah J. Laible, Gustavo Carlo, Scott C. Roesch

Department of Psychology: Faculty Publications

The goal of this study was to examine both the direct and indirect relations of parent and peer attachment with self-esteem and to examine the potential mediating roles of empathy and social behavior. 246 college students (Mage = 18.6 years, s.d. = 1.61) completed self-report measures of parent and peer attachment, empathy, social behavior, and self-esteem. Structural equation modeling revealed that parental attachment had mostly direct effects on self-esteem. Among females, the links between peer attachment and self-esteem, however, were entirely mediated by empathy and prosocial behavior. The findings from this study suggest that although close supportive relationships with parents …

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The Contribution Of Executive Functions To Emergent Mathematic Skills In Preschool Children, Kimberly Espy, Melanie D. Mcdiarmid, Mary F. Cwik, Melissa Meade Stalets, Arlena Hamby, Theresa E. Senn Nov 2004

The Contribution Of Executive Functions To Emergent Mathematic Skills In Preschool Children, Kimberly Espy, Melanie D. Mcdiarmid, Mary F. Cwik, Melissa Meade Stalets, Arlena Hamby, Theresa E. Senn

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Mathematical ability is related to both activation of the prefrontal cortex in neuroimaging studies of adults and to executive functions in school-age children. The purpose of this study was to determine whether executive functions were related to emergent mathematical proficiency in preschool children. Preschool children (N= 96) were administered an executive function battery that was reduced empirically to working memory (WM), inhibitory control (IC), and shifting abilities by calculating composite scores derived from principal component analysis. Both WM and IC predicted early arithmetic competency, with the observed relations robust after controlling statistically for child age, maternal education, and child vocabulary. …

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Endocrine System, Richard A. Dienstbier Nov 2004

Endocrine System, Richard A. Dienstbier

Department of Psychology: Faculty Publications

In complex animals the two principal systems of regulation are the endocrine system and the nervous systems. The endocrine system consists of the ductless endocrine glands, which secrete hormones directly into the bloodstream. The endocrine system and the autonomic nervous system both regulate most of the involuntary functions of the body, including circulatory functions (e.g., blood pressure and heart rate), energy and arousal levels, reproductive functions, and the immune system. Another major function of endocrine hormones is to regulate tissue growth in young, developing organisms. This abbreviated summary of endocrine system responses to challenge and threat illustrates some of the …

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Daily Experiences Of Emotions And Social Contexts Of Securely And Insecurely Attached Young Adults, Julia C. Torquati, Marcela Raffaelli Nov 2004

Daily Experiences Of Emotions And Social Contexts Of Securely And Insecurely Attached Young Adults, Julia C. Torquati, Marcela Raffaelli

Department of Psychology: Faculty Publications

This study examined daily emotions and social contexts of young adults who differed in global attachment style (secure vs. insecure). Sixty-nine college students (41% male, 59% female) completed self-report measures of attachment and provided timesampling data on moods, companionship, and activities using the experience sampling method. Secure (n = 41) and insecure (n = 28) young adults spent a similar proportion of time with familiar intimates and alone. Secure individuals reported significantly more positive affect, higher levels of energy, and more connection than insecure individuals when they were alone and higher levels of energy and connection in the context …

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Children’S Perceptions Of Family Relationships As Assessed In A Doll Story Completion Task: Links To Parenting, Social Competence, And Externalizing Behavior, Deborah Laible, Gustavo Carlo, Julia C. Torquati, Lenna Ontai Nov 2004

Children’S Perceptions Of Family Relationships As Assessed In A Doll Story Completion Task: Links To Parenting, Social Competence, And Externalizing Behavior, Deborah Laible, Gustavo Carlo, Julia C. Torquati, Lenna Ontai

Department of Psychology: Faculty Publications

This study was designed to examine the links between parenting, children’s perceptions of family relationships, and children’s social behavior. Seventy-four children (M age = 6.01 years; 39 boys; 35 girls) and their parents took part in the study. Children completed relationship-oriented doll stories that were coded for coherence, prosocial themes, and aggressive themes. Parents completed a report of their child’s social behavior, a parenting scale, and a number of demographic items. Teachers also completed measures of children’s social competence and externalizing behavior. Warm parenting predicted both a child’s representation of prosocial themes in the doll stories and social competence, whereas …

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The Differential Relations Of Maternal And Paternal Support And Control To Adolescent Social Competence, Self-Worth, And Sympathy, Deborah J. Laible, Gustavo Carlo Nov 2004

The Differential Relations Of Maternal And Paternal Support And Control To Adolescent Social Competence, Self-Worth, And Sympathy, Deborah J. Laible, Gustavo Carlo

Department of Psychology: Faculty Publications

The goal of this study was to examine how the parenting dimensions of both mothers and fathers independently and together predict adolescent outcomes in three domains: sympathy, self-worth, and social competence. One-hundred eight adolescents completed self report measures on their perceived relationship with parents, sympathy, social competence, and self-worth. Perceived maternal support and rigid control were the most consistent predictors of adolescent adjustment. High levels of perceived maternal support and low levels of maternal rigid control were related to adolescents’ reports of sympathy, social competence, and self-worth. In contrast, support and control from fathers was generally unrelated to adolescent adjustment. …

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The Development Of A Trial Making Test In Young Children: The Trails-P, Kimberly Espy, Mary F. Cwik Nov 2004

The Development Of A Trial Making Test In Young Children: The Trails-P, Kimberly Espy, Mary F. Cwik

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Preschool children have a more limited verbal repertoire, less proficient manual skills, and more variable attention spans relative to those of school age, with comparatively few neuropsychological tasks available for use in this age range. A prototypic neuropsychological test, the Trail Making Test, was adapted for use with young children, the TRAILS-P, using a developmentally salient storybook format with colorful stimuli in differing conditions with varying executive demands. The TRAILS-P was administered to 103 normally developing preschoolers between 2 and 6 years of age; 30 of these children were retested within one month to determine test reliability. Correlations among latencies …

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Using Developmental, Cognitive, And Neuroscience Approaches To Understand Executive Control In Young Children, K. A. Espy Nov 2004

Using Developmental, Cognitive, And Neuroscience Approaches To Understand Executive Control In Young Children, K. A. Espy

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

The 7 articles in this special issue address the nature of executive control in young children. Executive control is framed in a developmental context, where the unique aspects of cognition in this age range are considered. The set of articles demonstrates the multidisciplinary approaches to study cognition in young children that includes application of cognitive, neuroscience, and developmental paradigms in typically developing youngsters, as well as those affected by clinical conditions, such as traumatic brain injury, exposure to low levels of lead in the environment, and prematurity. Although much work remains to be done, these study results are illustrative of …

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Executive Function In Preschool Children: Examination Through Everyday Behavior, P. K. Isquith, G. Gioia, K. A. Espy Nov 2004

Executive Function In Preschool Children: Examination Through Everyday Behavior, P. K. Isquith, G. Gioia, K. A. Espy

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Clinical assessment of executive function in preschool-age children is challenging given limited availability of standardized tasks and preschoolers' variable ability to participate in lengthy formal evaluation procedures. Given the benefits of ecological validity of measuring behavior by rating scales, the Behavior Rating Inventory of Executive Function (Gioia, Isquith, Guy, & Kenworthy, 2000) was modified for use with children ages 2 through 5 years to assess executive functions in an everyday context. The scale development process, based on samples of 460 parents and 302 teachers, yielded a single 63-item measure with 5 related, but nonoverlapping, scales, with good internal consistency and …

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Using Path Analysis To Understand Executive Function Organization In Preschool Children, T. E. Senn, K. A. Espy, P. M. Kaufmann Nov 2004

Using Path Analysis To Understand Executive Function Organization In Preschool Children, T. E. Senn, K. A. Espy, P. M. Kaufmann

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

There continues to be no consensus definition of executive functions. One way to understand different executive function components is to study abilities at their emergence, that is, early in development, and use advanced statistical methods to understand the interrelations among executive processes. However, to fully determine the constructs of interest, these methods often require complete data on a large battery of tasks, which are difficult to obtain with young children. Path analysis is an alternative statistical technique that requires only a single measure of each construct, yet still allows researchers to investigate complex relations among measures, to compare nested models, …

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A Comparison Of Performance On The Towers Of London And Hanoi In Young Children, Rebecca Bull, Kimberly A. Espy, Theresa E. Senn Nov 2004

A Comparison Of Performance On The Towers Of London And Hanoi In Young Children, Rebecca Bull, Kimberly A. Espy, Theresa E. Senn

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

The Towers of London (TOL) and Hanoi (TOH) have been viewed as equivalent measures of planning and/or problem solving, although recent evidence in adults suggests that the underlying measurement characteristics of these two tasks may differ. As tower tasks are one of the few instruments that can be used to assess executive functioning in young children, the cognitive demands for both tasks merit further examination. Methods: The relation among tower tasks and those of short-term memory, inhibition, and shifting ability were examined in a sample of 118 typically developing young children (M age = 4 years, 9 months, SD = …

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Development Of Auditory Event-Related Potentials In Young Children And Relations To Word-Level Reading Abilities At Age 8 Years, Kimberly Espy, Dennis L. Molfese, Victoria J. Molfese, Arlene Modglin Nov 2004

Development Of Auditory Event-Related Potentials In Young Children And Relations To Word-Level Reading Abilities At Age 8 Years, Kimberly Espy, Dennis L. Molfese, Victoria J. Molfese, Arlene Modglin

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

A relationship between brain responses at birth and later emerging language and reading skills have been shown, but questions remain whether changes in brain responses after birth continue to predict the mastery of language-related skills such as reading development. To determine whether developmental changes in the brain-based perceptual skills are systematically related to differences in word-level reading proficiency at age 8 years, brain event-related potentials (ERPs) to speech and nonspeech stimuli were recorded annually at the ages of 1 through 8 years in a sample of 109 typically developing children. Two measures of word-level reading (one that requires decoding of …

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Investigation Of The Transmission Of Mycobacterium Bovis From Deer To Cattle Through Indirect Contact, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple Nov 2004

Investigation Of The Transmission Of Mycobacterium Bovis From Deer To Cattle Through Indirect Contact, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Objective—To investigate the infection of calves with Mycobacterium bovis through oral exposure and transmission of M bovis from experimentally infected white-tailed deer to uninfected cattle through indirect contact.

Animals—24 11-month-old, white-tailed deer and 28 6-month-old, crossbred calves.

Procedure—In the oral exposure experiment, doses of 4.3 X 106 CFUs (high dose) or 5 X 103 CFUs (low dose) of M bovis were each administered orally to 4 calves; as positive controls, 2 calves received M bovis (1.7 X 105 CFUs) via tonsillar instillation. Calves were euthanatized and examined 133 days after exposure. Deer-to-cattle transmission was …

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Identification Of Common Subpopulations Of Non-Sorbitol-Fermenting, Β-Glucuronidase-Negative Escherichia Coli O157:H7 From Bovine Production Environments And Human Clinical Samples, Zhijie Yang, Joy Kovar, Jaehyoung Kim, Joseph Nietfeldt, David R. Smith, Rodney A. Moxley, Michael E. Olson, Paul D. Fey, Andrew K. Benson Nov 2004

Identification Of Common Subpopulations Of Non-Sorbitol-Fermenting, Β-Glucuronidase-Negative Escherichia Coli O157:H7 From Bovine Production Environments And Human Clinical Samples, Zhijie Yang, Joy Kovar, Jaehyoung Kim, Joseph Nietfeldt, David R. Smith, Rodney A. Moxley, Michael E. Olson, Paul D. Fey, Andrew K. Benson

School of Veterinary and Biomedical Sciences: Faculty Publications

Non-sorbitol-fermenting, β-glucuronidase-negative Escherichia coli O157:H7 strains are regarded as a clone complex, and populations from different geographical locations are believed to share a recent common ancestor. Despite their relatedness, high-resolution genotyping methods can detect significant genome variation among different populations. Phylogenetic analysis of high-resolution genotyping data from these strains has shown that subpopulations from geographically unlinked continents can be divided into two primary phylogenetic lineages, termed lineage I and lineage II, and limited studies of the distribution of these lineages suggest there could be differences in their propensity to cause disease in humans or to be transmitted to humans. Because …

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Seasonality Of Tuberculosis In India: Is It Real And What Does It Tell Us?, Lorna E. Thorpe, Thomas R. Frieden, Kayla F. Laserson, Charles Wells, Gulshan Khatri Oct 2004

Seasonality Of Tuberculosis In India: Is It Real And What Does It Tell Us?, Lorna E. Thorpe, Thomas R. Frieden, Kayla F. Laserson, Charles Wells, Gulshan Khatri

Michigan Bovine Tuberculosis Bibliography and Database

India has a third of the world’s tuberculosis cases. Large-scale expansion of a national program in 1998 has allowed for population-based analyses of data from tuberculosis registries. We assessed seasonal trends using quarterly reports from districts with stable tuberculosis control programs (population 115 million). In northern India, tuberculosis diagnoses peaked between April and June, and reached a nadir between October and December, whereas no seasonality was reported in the south. Overall, rates of new smear-positive tuberculosis cases were 57 per 100 000 population in peak seasons versus 46 per 100 000 in trough seasons. General health-seeking behavior artifact was ruled …

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“It’S Not Fair!” Adolescents’ Constructions Of Appropriateness Of Parental Reactions, Laura M. Padilla-Walker, Gustavo Carlo Oct 2004

“It’S Not Fair!” Adolescents’ Constructions Of Appropriateness Of Parental Reactions, Laura M. Padilla-Walker, Gustavo Carlo

Department of Psychology: Faculty Publications

Research suggests that perceived appropriateness of parental discipline plays a role in whether adolescents accept or reject parental messages, but little is known about how adolescents conceptualize or construct their ideas of appropriateness. One hundred twenty-two adolescents (M age = 16.87) answered questions about past situations (both antisocial and prosocial), how parents responded to these situations, the adolescent’s perceived appropriateness of the parent’s reaction, how the parent’s reaction made the adolescent feel, and what the adolescent thought the parent’s intentions were. Appropriateness ratings were related to the type of parental discipline used, with yelling associated with lower ratings of appropriateness …

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Myelin Proteolipid Protein-Specific Cd4+ Cd25+ Regulatory Cells Mediate Genetic Resistance To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Zsolt Illés, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, Vijay K. Kuchroo, James P. Allison Oct 2004

Myelin Proteolipid Protein-Specific Cd4+ Cd25+ Regulatory Cells Mediate Genetic Resistance To Experimental Autoimmune Encephalomyelitis, Jay Reddy, Zsolt Illés, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, Vijay K. Kuchroo, James P. Allison

Jay Reddy Publications

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139–151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139–151-specific T cells in the naive repertoire of SJL mice. To understand the mechanism of EAE resistance in B10.S mice, we determined the precursor frequency of PLP 139–151-reactive T cells in both strains by using IAs/PLP 139–151 tetramers. SJL and B10.S mice had similar frequencies of tetramer-reactive T cells in the naive peripheral repertoire. However, in SJL mice, the …

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Cytokines And Synthetic Double-Stranded Rna Augment The T Helper 1 Immune Response Of Swine To Porcine Reproductive And Respiratory Syndrome Virus, William A. Meier, Robert J. Husmann, William M. Schnitzlein, Fernando A. Osorio, Joan K. Lunney, Federico A. Zuckermann Oct 2004

Cytokines And Synthetic Double-Stranded Rna Augment The T Helper 1 Immune Response Of Swine To Porcine Reproductive And Respiratory Syndrome Virus, William A. Meier, Robert J. Husmann, William M. Schnitzlein, Fernando A. Osorio, Joan K. Lunney, Federico A. Zuckermann

School of Veterinary and Biomedical Sciences: Faculty Publications

Immunization of pigs with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine initially elicits a weak interferon (IFN)-γ response. To improve the immune response, an adjuvant consisting of plasmid encoding either porcine interleukin (IL)-12 or IFN-α was co-administered during vaccination. In the presence of either adjuvant, at least a threefold increase in the primary virus-specific IFN-γ response was observed. While this enhancement was only transient (1 week) when the IL-12 expressing plasmid was used, the effect was not only still apparent at 6 weeks after vaccination in the presence of the IFN-α expressing plasmid but even after …

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Beyond Bloodletting: Fda Gives Leeches A Medical Makeover, Carol Rados Oct 2004

Beyond Bloodletting: Fda Gives Leeches A Medical Makeover, Carol Rados

Harold W. Manter Laboratory of Parasitology: Library Materials

In June 2004, the Food and Drug Administration cleared the first application for leeches (Hirudo medicinalis) to be used in modern medicine as medical devices. By definition, a medical device is an article intended to diagnose, cure, treat, prevent, or mitigate a disease or condition, or to affect a function or structure of the body, that does not achieve its primary effect through a chemical action and is not metabolized.

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Johne’S Disease, Inflammatory Bowel Disease, And Mycobacterium Paratuberculosis, Ofelia Barletta-Chacon, Luiz E. Bermudez, Raúl G. Barletta Oct 2004

Johne’S Disease, Inflammatory Bowel Disease, And Mycobacterium Paratuberculosis, Ofelia Barletta-Chacon, Luiz E. Bermudez, Raúl G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Johne’s disease is a chronic diarrhea affecting all ruminants. Mycobacterium avium subsp. paratuberculosis (MAP), a slowly growing mycobacteria, is the etiologic agent. There is also a concern that MAP might be a causative agent of some cases of inflammatory bowel disease in humans, especially Crohn’s disease. Food products including pasteurized bovine milk have been suggested as potential sources of human infection. This review addresses microbial factors that may contribute to its pathogenicity. In addition, the experimental evidence defining MAP as the cause of Johne’s disease and the issues and controversies surrounding its potential pathogenic role in humans are discussed.

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Waccnes Containing Bovine Herpe Svirus 1 Attenuated By Mutation In Latency-Related Gene, Clinton J. Jones Sep 2004

Waccnes Containing Bovine Herpe Svirus 1 Attenuated By Mutation In Latency-Related Gene, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Vaccines for pathogenic Strains of bovine herpesvirus 1 (BHV-1) which are based on attenuated BHV-1 having a mutation in the latency-related gene are provided. Live, attenuated vaccines are also provided which express anti gens from other viral or bacterial pathogens and thus form the basis of a variety of vaccines.

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The Effects Of A Commercial Aluminum Airpolishing Powder On Dental Restorative Materials, William W. Johnson, Caren M. Barnes, David A. Covey, Mary P. Walker, Judith A. Ross Sep 2004

The Effects Of A Commercial Aluminum Airpolishing Powder On Dental Restorative Materials, William W. Johnson, Caren M. Barnes, David A. Covey, Mary P. Walker, Judith A. Ross

College of Dentistry: Faculty Publications

Introduction: JET-Fresh™ (Dentsply International, York, PA), a new airpolishing powder that contains aluminum trihydroxide as the abrasive agent, has been introduced for use with Prophy-Jet™ (Dentsply International).
Purpose: The aim of this study was to investigate the surface effects of aluminum trihydroxide airpolishing powder on a series of restorative materials.
Materials and Methods: A total of 6 Class V preparations with enamel margins were created on the buccal surface of extracted human molars. The preparations were restored with Type III gold, a high copper spherical alloy amalgam, porcelain, a lightactivated hybrid composite material, a light-activated microfilled composite material, and a …

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Cancer Incidence Among Pesticide Applicators Exposed To Atrazine In The Agricultural Health Study, Jennifer A. Rusiecki, Anneclaire De Roos, Won Jin Lee, Mustafa Dosemeci, Jay H. Lubin, Jane A. Hoppin, Aaron Blair, Michael C. R. Alavanja Sep 2004

Cancer Incidence Among Pesticide Applicators Exposed To Atrazine In The Agricultural Health Study, Jennifer A. Rusiecki, Anneclaire De Roos, Won Jin Lee, Mustafa Dosemeci, Jay H. Lubin, Jane A. Hoppin, Aaron Blair, Michael C. R. Alavanja

United States Public Health Resources

Background: Atrazine is the most heavily applied agricultural pesticide for crop production in the United States. Both animal and human studies have suggested that atrazine is possibly carcinogenic, but results have been mixed. We evaluated cancer incidence in atrazine-exposed pesticide applicators among 53 943 participants in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina.
Methods: We obtained detailed pesticide exposure information using a self-administered questionnaire completed at the time of enrollment (1993–1997). Cancer incidence was followed through December 31, 2001. We used adjusted Poisson regression to calculate rate ratios (RRs) and …

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Nicotine Serves As A Feature-Positive Modulator Of Pavlovian Appetitive Conditioning In Rats, M. I. Palmatier, J. L. Peterson, J. L. Wilkinson, Rick A. Bevins Sep 2004

Nicotine Serves As A Feature-Positive Modulator Of Pavlovian Appetitive Conditioning In Rats, M. I. Palmatier, J. L. Peterson, J. L. Wilkinson, Rick A. Bevins

Department of Psychology: Faculty Publications

The present experiments examined whether a nicotine state could set the occasion for a pairing between visual cues and a rewarding outcome in rats. Following nicotine administration, presentation of a conditional stimulus (CS; light-on) was followed by brief access to a sucrose solution. When saline was administered, the same CS was presented but was not followed by any consequence. In Experiment 1, two groups assessed whether rats could acquire this Pavlovian feature-positive discrimination via different training procedures. An anticipatory food-seeking conditioned response (CR) developed during the CS on nicotine sessions but not on saline sessions in both groups. In Experiment …

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Extending The Role Of Associative Learning Processes In Nicotine Addiction., Rick A. Bevins, Matthew I. Palmatier Sep 2004

Extending The Role Of Associative Learning Processes In Nicotine Addiction., Rick A. Bevins, Matthew I. Palmatier

Department of Psychology: Faculty Publications

Compulsive smoking is a worldwide public health problem. Although research has confirmed the importance of associative learning processes in nicotine addiction, therapies targeting nicotine-associated cues still have a high relapse rate. Most theories conceptualize nicotine as an 'outcome' that reinforces behaviors and/or changes the affective value of stimuli. Albeit important, this view does not capture the complexity of associative processes involved in nicotine addiction. For example, nicotine serves as a conditional stimulus acquiring new appetitive/affective properties when paired with a non-drug reward. Also, nicotine functions as an occasion setter that participates in higher-order associative processes that likely permit a more …

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Individual And Social Influences On Ethnic Identity Among Latino Young Adults, Lenna L. Ontai-Grzebik, Marcela Raffaelli Sep 2004

Individual And Social Influences On Ethnic Identity Among Latino Young Adults, Lenna L. Ontai-Grzebik, Marcela Raffaelli

Department of Psychology: Faculty Publications

Building on prior Latino ethnic identity research, this study had three goals: describe age-related trends in ethnic identity among young adults, examine relations among ethnic identity and individual factors, and explore the impact of family and peer socialization on ethnic identity. The participants (two hundred 19-to 30-year-olds; mean age = 22.5) completed self-report surveys sent to Latino undergraduate and graduate students enrolled in four midwestern institutions of higher education. The findings suggest individual factors are strong predictors of ethnic identity during early adulthood; respondents who were younger, high on Latino orientation, spent more time in the United States, and whose …

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West Nile Virus Infection In Reindeer (Rangifer Tarandus), Mitchell V. Palmer, William C. Stoffregen, Douglas G. Rogers, Amir N. Hamir, Juergen A. Richt, Douglas D. Pedersen, W. Ray Waters Sep 2004

West Nile Virus Infection In Reindeer (Rangifer Tarandus), Mitchell V. Palmer, William C. Stoffregen, Douglas G. Rogers, Amir N. Hamir, Juergen A. Richt, Douglas D. Pedersen, W. Ray Waters

School of Veterinary and Biomedical Sciences: Faculty Publications

West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from …

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