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Articles 3871 - 3900 of 5204

Full-Text Articles in Medicine and Health Sciences

Juror Reactions To Jury Duty: Perceptions Of The System And Potential Stressors, Brian H. Bornstein, Monica Miller, Robert J. Nemeth, Gregory L. Page, Sarah Musil May 2005

Juror Reactions To Jury Duty: Perceptions Of The System And Potential Stressors, Brian H. Bornstein, Monica Miller, Robert J. Nemeth, Gregory L. Page, Sarah Musil

Department of Psychology: Faculty Publications

Jurors were surveyed on their general perceptions of the court system and factors that may cause stress immediately after trial, after participating in a post-trial debriefing, and a month after trial. Jurors had an overall positive view of the court system but did report some perceived inequities. The two most stressful elements of jury duty were related to the complexity of the trial and the decision-making involved in the trial, although jurors reported low levels of stress overall. Women reported more stress than men, and trial characteristics such as trial length also affected stress levels. The debriefing intervention was perceived …

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“You Would If You Loved Me”: Toward An Improved Conceptual And Etiological Understanding Of Nonphysical Male Sexual Coercion, Sarah A. Degue, David Dilillo May 2005

“You Would If You Loved Me”: Toward An Improved Conceptual And Etiological Understanding Of Nonphysical Male Sexual Coercion, Sarah A. Degue, David Dilillo

Department of Psychology: Faculty Publications

This paper reviews current research regarding the prevalence and possible etiological factors associated with male sexual coercion, defined here as a class of inappropriate male behaviors in which nonphysical tactics (e.g., verbal pressure, lying, deceit, and continual arguments) are utilized to obtain sexual contact with an unwilling adult female. This form of sexual misconduct is contrasted with sexual aggression (i.e., forcible rape), in which the threat or use of physical force is utilized to gain sexual contact. A conceptual framework for understanding and examining sexual coercion within the broader context of male sexual misconduct is offered. This model consists of …

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Novelty Reward As A Measure Of Anhedonia, Rick A. Bevins, Joyce Besheer May 2005

Novelty Reward As A Measure Of Anhedonia, Rick A. Bevins, Joyce Besheer

Department of Psychology: Faculty Publications

A decrease in sensitivity to pleasurable stimuli, anhedonia, is a major symptom of depression in humans. Several animal models have been developed to simulate this symptom (e.g. drug withdrawal, learned helplessness) using reward-sensitive procedures such as intracranial self-stimulation and progressive ratio responding as a measure of reward function. Recently, we introduced the use of another procedure, novel-object place conditioning in rats, to measure reward function in an associative learning situation. Withdrawal from chronic nicotine blocked a place preference conditioned by access to novel objects. This blockade was not due to impairment of object interaction, general activity, novelty detection, environmental familiarization, …

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Modeling Of Immunoglobulin Uptake By N,N,N′,N′-Ethylenediaminetetramethylenephosphonic Acid-Modified Zirconia Particles Under Static And Dynamic Conditions, Sabyasachi Sarkar, Anuradha Subramanian May 2005

Modeling Of Immunoglobulin Uptake By N,N,N′,N′-Ethylenediaminetetramethylenephosphonic Acid-Modified Zirconia Particles Under Static And Dynamic Conditions, Sabyasachi Sarkar, Anuradha Subramanian

Papers in Biotechnology

A matrix developed from N,N,N′,N′-ethylenediaminetetramethylenephosphonic acid-modified zirconia beads (further referred to as r_PEZ); 25–38 μm in diameter and with a pore size of 22 ± 3 nm, was utilized for the separation of immunoglobulins (Igs). r_PEZ has been shown to bind to various Igs originating from a wide variety of species. To understand the mechanisms controlling the uptake of Igs by r_PEZ, static protein uptake experiments were carried out. The protein uptake profiles were further modeled with a kinetic rate constant model. Individual studies were undertaken for human immunoglobulin A, G and M (HIgA, HIgG and HIgM). The kinetic rate …

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The Locus Encompassing The Latency-Associated Transcript Of Herpes Simplex Virus Type 1 Interferes With And Delays Interferon Expression In Productively Infected Neuroblastoma Cells And Trigeminal Ganglia Of Acutely Infected Mice, Weiping Peng, Gail A. Henderson, Melissa Inman, Lbachir Benmohamed, Guey-Chuen Perng, Steven L. Wechsler, Clinton J. Jones May 2005

The Locus Encompassing The Latency-Associated Transcript Of Herpes Simplex Virus Type 1 Interferes With And Delays Interferon Expression In Productively Infected Neuroblastoma Cells And Trigeminal Ganglia Of Acutely Infected Mice, Weiping Peng, Gail A. Henderson, Melissa Inman, Lbachir Benmohamed, Guey-Chuen Perng, Steven L. Wechsler, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only abundant viral transcript expressed in latently infected neurons. LAT inhibits apoptosis, suggesting that it regulates latency by promoting the survival of infected neurons. The LAT locus also contains a newly described gene (AL), which is antisense to LAT and partially overlaps LAT encoding sequences. When human (SK-N-SH) or mouse (neuro-2A) neuroblastoma cells were infected with a virus that does not express LAT or AL gene products (dLAT2903), beta interferon (IFN- β) and IFN- α RNA expression was detected earlier relative to the same cells infected with HSV-1 …

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Tularemia: Emergence/Re-Emergence, Jeannine M. Petersen, Martin E. Schriefer Apr 2005

Tularemia: Emergence/Re-Emergence, Jeannine M. Petersen, Martin E. Schriefer

Zoonotics and Wildlife Disease: Publications

Francisella tularensis is a gram-negative coccobacillus and the etiologic agent of the zoonotic disease tularemia. First described in 1911 in Tulare County, California, it has since been reported throughout the Northern Hemisphere, with natural infections reported among an unusually wide range of vertebrates and invertebrates. In recent years, tularemia has emerged in new geographic locations, populations, and settings. This review will serve to highlight mechanisms contributing to the recent emergence of tularemia as well as a repertoire of diagnostic tools useful for detecting and diagnosing disease.

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Histories Of Childhood Maltreatment In Schizophrenia: Relationships With Premorbid Functioning, Symptomatology, And Cognitive Deficits, Lindsay S. Schenkel, William D. Spaulding, David Dilillo, Steven M. Silverstein Apr 2005

Histories Of Childhood Maltreatment In Schizophrenia: Relationships With Premorbid Functioning, Symptomatology, And Cognitive Deficits, Lindsay S. Schenkel, William D. Spaulding, David Dilillo, Steven M. Silverstein

Department of Psychology: Faculty Publications

A number of studies have demonstrated an increased rate of histories of childhood maltreatment among adults with serious mental illness. The present investigation documented the presence of childhood maltreatment in a sample of 40 psychiatric inpatients with schizophrenia spectrum disorders. The type (neglect, physical abuse, sexual abuse), duration, and severity of childhood maltreatment was examined along with measures of premorbid functioning, current symptomatology, and cognitive functioning. Participants with histories of maltreatment were significantly more likely to have poorer peer relationships in childhood, more diffi culty in school, an earlier age at first hospitalization, more previous hospitalizations, elevated symptoms of anxiety, …

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Timing Of Conditioned Responding In A Nicotine Locomotor Conditioning Preparation: Manipulations Of The Temporal Arrangement Between Context Cues And Drug Administration, Rick A. Bevins, Sarah Eurek, Joyce Besheer Apr 2005

Timing Of Conditioned Responding In A Nicotine Locomotor Conditioning Preparation: Manipulations Of The Temporal Arrangement Between Context Cues And Drug Administration, Rick A. Bevins, Sarah Eurek, Joyce Besheer

Department of Psychology: Faculty Publications

Using a locomotor conditioning preparation, we examined whether manipulating time between exposure to distinct environmental cues and nicotine administration affected conditioned responding. Rats that received nicotine (0.42 mg/kg base) immediately before placement in an environment for 30 min on eight separate occasions displayed hyperactivity relative to controls in a subsequent injection/drug-free test. This conditioned hyperactivity was weaker if nicotine was administered 15 min before environment exposure. Conditioning was not evidenced when nicotine was administered 15 min after placement or upon removal from the environment. In a follow-up experiment, rats received 45 min in the environment; nicotine was administered 15 min …

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Current Mood And Food Choices: The Relation Between Positive Affect And Dietary Behavior, Kristi E. White, Amy M. Humke, Marc T. Kiviniemi Apr 2005

Current Mood And Food Choices: The Relation Between Positive Affect And Dietary Behavior, Kristi E. White, Amy M. Humke, Marc T. Kiviniemi

Department of Psychology: Faculty Publications

Colloquially, much is made of the relation between food and mood. For example, “comfort foods” are eaten in the service of affect regulation. Affect can influence behavioral choices in a number of ways. We investigated whether college students’ mood when making dietary choices influenced the nutritional value of the foods chosen. Sixty-five participants completed a questionnaire immediately prior to eating a meal in a college dining hall. The questionnaire included a measure of current positive affect. Following the meal, participants reported what they ate for dinner. Using nutritional data from the college dining services, we used participants’ self reported food …

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Should I Diet? What Should I Eat? Different Decision Making Factors Predict Dieting Intentions Versus Actual Dietary Behavior, Marc T. Kiviniemi, Kristi E. White, Amy M. Humke Apr 2005

Should I Diet? What Should I Eat? Different Decision Making Factors Predict Dieting Intentions Versus Actual Dietary Behavior, Marc T. Kiviniemi, Kristi E. White, Amy M. Humke

Department of Psychology: Faculty Publications

Many individuals diet to lose weight. Most attempts are not successful—weight is either not lost or is quickly regained.We investigated decision making factors influencing dieting intentions versus those influencing actual behavior. Prior to eating in a university cafeteria, 65 participants reported their cost-benefit beliefs about low fat foods and fruits/vegetables, affective associations with both food categories, and whether they were currently dieting to lose weight. After the meal, participants reported what they ate. Using these reports and nutritional data from the college dining service, we computed the calories, total and saturated fat, sodium, and cholesterol consumed. Cost-benefit beliefs and affective …

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Epidemiology Of Escherichia Coli O157:H7 Outbreaks, United States, 1982–2002, Josefa M. Rangel, Phyllis H. Sparling, Collen Crowe, Patricia M. Griffin, David L. Swerdlow Apr 2005

Epidemiology Of Escherichia Coli O157:H7 Outbreaks, United States, 1982–2002, Josefa M. Rangel, Phyllis H. Sparling, Collen Crowe, Patricia M. Griffin, David L. Swerdlow

United States Public Health Resources

Escherichia coli O157:H7 causes 73,000 illnesses in the United States annually. We reviewed E. coliO157 outbreaks reported to Centers for Disease Control and Prevention (CDC) to better understand the epidemiology of E. coli O157. E. coli O157 outbreaks (>2 cases of E. coli O157 infection with a common epidemiologic exposure) reported to CDC from 1982 to 2002 were reviewed. In that period, 49 states reported 350 outbreaks, representing 8,598 cases, 1,493 (17%) hospitalizations, 354 (4%) hemolytic uremic syndrome cases, and 40 (0.5%) deaths. Transmission route for 183 (52%) was foodborne, 74 (21%) unknown, 50 (14%) person-to-person, 31 (9%) …

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Construction And Validation Of A Children’S Interpersonal Trust Belief Scale, Ken J. Rotenberg, Claire Fox, Sarah Green, Louise Ruderman, Kevin Slater, Kelly Stevens, Gustavo Carlo Apr 2005

Construction And Validation Of A Children’S Interpersonal Trust Belief Scale, Ken J. Rotenberg, Claire Fox, Sarah Green, Louise Ruderman, Kevin Slater, Kelly Stevens, Gustavo Carlo

Department of Psychology: Faculty Publications

A scale was constructed to assess children’s generalized trust beliefs (CGTB) in four target groups (mother, father, teacher and peer) with respect to three bases of trust: reliability, emotionality, and honesty. The CGTB Scale was administered to 145 Year 5 and 156 Year 6 children (mean age = 10 years, 1 month) residing in the English Midlands, United Kingdom. Exploratory and confirmatory factor analyses yielded evidence for the expected factor structure of the CGTB Scale. The total CGTB Scale and subscales demonstrated acceptable internal consistency and expected levels of stability across time. As support for validity, Year 6 participants’ scores …

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Future Expectations Of Brasilian Street Youth, Marcela Raffaelli, Silvia H. Koller Apr 2005

Future Expectations Of Brasilian Street Youth, Marcela Raffaelli, Silvia H. Koller

Department of Psychology: Faculty Publications

Future expectations of youth surviving on the streets of Porto Alegre, Brasil, were examined. The sample consisted of 35 boys and 34 girls aged 10–18 (M age 14.4) who participated in a sentence completion task and semi-structured interviews. Responses to two incomplete sentences regarding the future revealed a mismatch between hoped-for and expected events. When completing the sentence, “In the future, I hope…” the majority of youth gave optimistic (but generally non-specific) responses. In contrast, the sentence “For me, the future…” elicited more pessimistic responses. Few gender or age-related differences emerged. Findings are discussed in light of prior research with …

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Nucleic Acid Sequencing Using Charge-Switch Nucleotides, John G. K. Williams, Gregory R. Bashford Mar 2005

Nucleic Acid Sequencing Using Charge-Switch Nucleotides, John G. K. Williams, Gregory R. Bashford

Biomedical Imaging and Biosignal Analysis Laboratory

The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.

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The Reference-Dose Place Conditioning Procedure Yields A Graded Dose-Effect Function, Rick A. Bevins Mar 2005

The Reference-Dose Place Conditioning Procedure Yields A Graded Dose-Effect Function, Rick A. Bevins

Department of Psychology: Faculty Publications

A major criticism of the place conditioning procedure for studying conditioned drug reward is that it is relatively insensitive to large quantitative shifts in drug dose (i.e., dose effects are all or none). Experiment 1 demonstrated this lack of sensitivity using a wide range of intravenous (IV) cocaine doses (O.1, 0.3, 0.45, 0.6, 0.9, or 1.2 mg/kg). Rats had cocaine repeatedly paired with one distinct end compartment of a 3 compartment apparatus; vehicle was administered in the other end compartment. In a subsequent drug-free choice test, the 0.45 to 1.2 mg/kg doses of cocaine conditioned a place preference. The magnitude …

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Evaluating Sex Offenders Under Sexually Violent Predator Laws: How Might Mental Health Professionals Conceptualize The Notion Of Volitional Impairment?, Cynthia Calkins Mercado, Robert F. Schopp, Brian H. Bornstein Mar 2005

Evaluating Sex Offenders Under Sexually Violent Predator Laws: How Might Mental Health Professionals Conceptualize The Notion Of Volitional Impairment?, Cynthia Calkins Mercado, Robert F. Schopp, Brian H. Bornstein

Department of Psychology: Faculty Publications

This paper examines the significance of the Supreme Court’s Hendricks and Crane decisions, with focus given to how mental health professionals may conceptualize the notion of volitional impairment. The Hendricks decision authorized postsentence civil commitment for sex offenders having a mental abnormality or personality disorder, rendering them likely to engage in future acts of sexual violence. In the Supreme Court’s majority opinion, Justice Thomas implied that the Kansas Act was legitimized by limiting the class of offenders eligible for this specialized form of commitment to those who are “unable to control” their dangerousness. In Crane, the Court ruled that …

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Epistasis Among Presynaptic Serotonergic System Components, Scott F. Stoltenberg Mar 2005

Epistasis Among Presynaptic Serotonergic System Components, Scott F. Stoltenberg

Department of Psychology: Faculty Publications

Epistatic interactions among regulatory components of the serotonin (5-HT) neurotransmitter system may be an important aspect of 5-HT function. Because 5-HT dysregulation is associated with several common psychiatric disorders, the potential for epistasis among genetic variants in the 5-HT transporter (SERT), 5-HT1B terminal autoreceptor and the 5- HT1A somatodendritic autoreceptor should be examined. In this study, output from a dynamic minimal model of 5-HT function was compared to empirical results in the literature. Parameters representing extracellular 5-HT clearance rates (SERT), 5-HT release levels (5-HT1B) and inhibitory thresholds (the amount of extracellular 5-HT above which cell firing …

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5-Ht1b Receptor-Mediated Presynaptic Inhibition Of Gaba Release In The Suprachiasmatic Nucleus, Jayne R. Bramley, Patricia J. Sollars, Gary E. Pickard, F. Edward Dudek Feb 2005

5-Ht1b Receptor-Mediated Presynaptic Inhibition Of Gaba Release In The Suprachiasmatic Nucleus, Jayne R. Bramley, Patricia J. Sollars, Gary E. Pickard, F. Edward Dudek

School of Veterinary and Biomedical Sciences: Faculty Publications

The suprachiasmatic nucleus (SCN) receives a dense serotonergic innervation that modulates photic input to the SCN via serotonin 1B (5-HT1B) presynaptic receptors on retinal glutamatergic terminals. However, the majority of 5-HT1B binding sites in the SCN are located on nonretinal terminals and most axonal terminals in the SCN are GABAergic. We therefore tested the hypothesis that 5-HT1B receptors might also be located on SCN GABAergic terminals by examining the effects of the highly selective 5-HT1B receptor agonist CP-93,129 on SCN miniature inhibitory postsynaptic currents (mIPSCs). Whole cell patch-clamp recordings of mIPSCs were obtained from rat …

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A Monkey’S Tale: The Origin Of Plasmodium Vivax As A Human Malaria Parasite, Ananias A. Escalante, Omar E. Cornejo, Denise E. Freeland, Amanda C. Poe, Ester Durrego, William E. Collins, Altaf A. Lal Feb 2005

A Monkey’S Tale: The Origin Of Plasmodium Vivax As A Human Malaria Parasite, Ananias A. Escalante, Omar E. Cornejo, Denise E. Freeland, Amanda C. Poe, Ester Durrego, William E. Collins, Altaf A. Lal

Harold W. Manter Laboratory of Parasitology: Library Materials

The high prevalence of Duffy negativity (lack of the Duffy blood group antigen) among human populations in sub-Saharan Africa has been used to argue that Plasmodium vivax originated on that continent. Here, we investigate the phylogenetic relationships among 10 species of Plasmodium that infect primates by using three genes, two nuclear (β-tubulin and cell division cycle 2) and a gene from the plastid genome (the elongation factor Tu). We find compelling evidence that P. vivax is derived from a species that inhabited macaques in Southeast Asia. Specifically, those phylogenies that include P. vivax as an ancient lineage from …

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Peptide 15-Mers Of Defined Sequence That Substitute For Random Amino Acid Copolymers In Amelioration Of Experimental Autoimmune Encephalomyelitis, Joel N.H. Stern, Zsolt Illés, Jay Reddy, Derin B. Keskin, Masha Fridkis-Hareli, Vijay K. Kuchroo, Jack L. Strominger Feb 2005

Peptide 15-Mers Of Defined Sequence That Substitute For Random Amino Acid Copolymers In Amelioration Of Experimental Autoimmune Encephalomyelitis, Joel N.H. Stern, Zsolt Illés, Jay Reddy, Derin B. Keskin, Masha Fridkis-Hareli, Vijay K. Kuchroo, Jack L. Strominger

Jay Reddy Publications

Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85–99, forms a complex with human leukocyte antigen (HLA)-DR2 with which multiple sclerosis is genetically associated. Copolymer 1 (Copaxone), a random amino acid copolymer [poly (Y,E,A,K)n] as well as two modified synthetic copolymers [poly (F,Y,A,K)n and poly (V,W,A,K)n] also form complexes with HLA-DR2 (DRA DRB1*1501) and compete with MBP 85–99 for binding. Moreover, two high-affinity synthetic peptide 15-mers that could inhibit binding even more effectively were previously designed. Here, we show that further-modified peptide 15-mers inhibited even more strongly (in order J5 > J3 …

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Chronic Wasting Disease (Cwd) Data Clearinghouse Jan 2005

Chronic Wasting Disease (Cwd) Data Clearinghouse

Zoonotics and Wildlife Disease: Publications

The National Biological Information Infrastructure (NBII) is an electronic information network that provides access to biological data and information on our nation’s plants, animals, and ecosystems. Information contributed by federal, state, and local government agencies; non-government organizations; and private-sector organizations is linked through the NBII gateway and made accessible to a variety of audiences, including researchers, natural resource managers, decision-makers, educators, students, and other members of the general public. Implementation of the NBII is being accomplished through the development of "nodes" that serve as entry points to the network. These nodes function as fully digital, distributed, and interactive systems that …

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Using Photography To Cross Generational, Linguistic, And Cultural Barriers To Develop Useful Survey Instruments., Ian Newman, Suree Kanjanawong Jan 2005

Using Photography To Cross Generational, Linguistic, And Cultural Barriers To Develop Useful Survey Instruments., Ian Newman, Suree Kanjanawong

Department of Educational Psychology: Faculty Publications

Photographs are used as a research tool by anthropologists and as a technique to empower special populations, advocacy groups, and policymakers. This case describes how photography was used to develop a survey to study alcohol expectancies among Thai adolescents. A multicultural research team faced generational, linguistic, and cultural barriers in understanding Thai adolescent alcohol use well enough to write useful questions about alcohol expectancies. Asking adolescents to take and then discuss their photographs about alcohol allowed them to express themselves without the imposition of an organizational framework by the investigators. Group discussions of the photographs revealed nuances and subtleties of …

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Thirteen Years Of Reflection On Auditory Graphing: Promises, Pitfalls, And Potential New Directions, John H. Flowers Jan 2005

Thirteen Years Of Reflection On Auditory Graphing: Promises, Pitfalls, And Potential New Directions, John H. Flowers

Department of Psychology: Faculty Publications

While developments in sound production hardware now make the creation of auditory graphs possible for casual users of personal computers, some of the same pitfalls to effective auditory display development that arose in the early 1990’s continue to impede effective applications of this promising technology. Most of these pitfalls stem from lack of adequate understanding about key properties of auditory perception and attention and from inappropriate generalizations of existing data visualization practices. At the same time, however, we now know about some strategies that appear to work and offer promise for making sonification a useful and accepted tool for data …

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Introduction: Moral Development Study In The 21st Century, Carolyn P. Edwards, Gustavo Carlo Jan 2005

Introduction: Moral Development Study In The 21st Century, Carolyn P. Edwards, Gustavo Carlo

Department of Psychology: Faculty Publications

Questions of right and wrong, good and bad, lawful and unlawful, have been debated by philosophers, theologians, scholars, and ordinary people since ancient times. The moral domain represents humanity's answers to three questions: What is the right thing to do? How is the best state of affairs achieved? What qualities make for a good person? However, the scientific investigation of the moral life has a much shorter intellectual history than does philosophical and religious reflection; nevertheless, it is not new. Moral development theory and research emerged as a critical topic over 100 years ago, at the beginning of the 20th …

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Evaluation Of Western Blotting Methods Using Samples With Or Without Sodium Phosphotungstic Acid Precipitation For Diagnosis Of Scrapie And Chronic Wasting Disease, Hongsheng Huang, Jasmine Rendulich, Dan Stevenson, Katherine I. O'Rourke, Aru Balachandran Jan 2005

Evaluation Of Western Blotting Methods Using Samples With Or Without Sodium Phosphotungstic Acid Precipitation For Diagnosis Of Scrapie And Chronic Wasting Disease, Hongsheng Huang, Jasmine Rendulich, Dan Stevenson, Katherine I. O'Rourke, Aru Balachandran

Zoonotics and Wildlife Disease: Publications

The purpose of this study was to enhance the sensitivity of the Western blot (WB) test for use as an alternative and confirmatory method for the diagnosis of scrapie and chronic wasting disease (CWD) in Canada by comparing 2 sample preparation procedures: an abnormal prion protein (PrPSc) concentration procedure using sodium phosphotungstic acid (PTA) precipitation and a procedure using crude sample without precipitation. A total of 100 cerebrum samples (52 sheep and 48 elk), including 66 negative (31 sheep, 35 elk) and 34 positive (21 scrapie and 13 CWD positive) samples diagnosed by using immunohistochemistry (IHC) on retropharyngeal …

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The Incidence Of Genotypes At Codon 171 Of The Prion Protein Gene (Prnp) In Five Breeds Of Sheep And Production Traits Of Ewes Associated With Those Genotypes, B. M. Alexander, R. H. Stobart, W. C. Russell, Katherine I. O'Rourke, G. S. Lewis, J. R. Logan, J. V. Duncan, G. E. Moss Jan 2005

The Incidence Of Genotypes At Codon 171 Of The Prion Protein Gene (Prnp) In Five Breeds Of Sheep And Production Traits Of Ewes Associated With Those Genotypes, B. M. Alexander, R. H. Stobart, W. C. Russell, Katherine I. O'Rourke, G. S. Lewis, J. R. Logan, J. V. Duncan, G. E. Moss

Zoonotics and Wildlife Disease: Publications

Scrapie is one of several transmissible spongiform encephalopathies of livestock. Disease susceptibility is linked to polymorphisms in the normal prion protein gene that encodes the mammalian prion precursor. Codon 171 of this gene is a major determinant of scrapie susceptibility. Selection for arginine (R) at codon 171 is encouraged by the USDA to decrease the incidence of scrapie. Objectives of this study were to determine the frequency of R allele variants at codon 171 in a sample of sheep from five breeds (Columbia, Hampshire, Rambouillet, Suffolk, and Targhee) and western white-faced commercial ewes and to determine whether the R allele …

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Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti Jan 2005

Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti

Zoonotics and Wildlife Disease: Publications

Chronic wasting disease (CWD), a prion disease affecting free-ranging and captive cervids (deer and elk), is widespread in the United States and parts of Canada. The large cervid population, the popularity of venison consumption, and the apparent spread of the CWD epidemic are likely resulting in increased human exposure to CWD in the United States. Whether CWDis transmissible to humans, as has been shown for bovine spongiform encephalopathy (the prion disease of cattle), is unknown. We generated transgenic mice expressing the elk or human prion protein (PrP) in a PrP-null background. After intracerebral inoculation with elk CWD prion, two lines …

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Predictive Spatial Dynamics And Strategic Planning For Raccoon Rabies Emergence In Ohio, James E. Childs, David L. Smith, Colin A. Russell, Leslie A. Real Jan 2005

Predictive Spatial Dynamics And Strategic Planning For Raccoon Rabies Emergence In Ohio, James E. Childs, David L. Smith, Colin A. Russell, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Rabies is an important public health concern in North America because of recent epidemics of a rabies virus variant associated with raccoons. The costs associated with surveillance, diagnostic testing, and post-exposure treatment of humans exposed to rabies have fostered coordinated efforts to control rabies spread by distributing an oral rabies vaccine to wild raccoons. Authorities have tried to contain westward expansion of the epidemic front of raccoonassociated rabies via a vaccine corridor established in counties of eastern Ohio, western Pennsylvania, and West Virginia. Although sporadic cases of rabies have been identified in Ohio since oral rabies vaccine distribution in 1998, …

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Experimental Transmission Of Chronic Wasting Disease Agent From Mule Deer To Cattle By The Intracerebral Route, Amir N. Hamir, Robert A. Kunkle, Randall C. Cutlip, Janice M. Miller, Katherine I. O'Rourke, Elizabeth S. Williams, Michael W. Miller, Mick J. Stack, Melanie J. Chaplin, Jügen A. Richt Jan 2005

Experimental Transmission Of Chronic Wasting Disease Agent From Mule Deer To Cattle By The Intracerebral Route, Amir N. Hamir, Robert A. Kunkle, Randall C. Cutlip, Janice M. Miller, Katherine I. O'Rourke, Elizabeth S. Williams, Michael W. Miller, Mick J. Stack, Melanie J. Chaplin, Jügen A. Richt

Zoonotics and Wildlife Disease: Publications

This communication reports final observations on experimental transmission of chronic wasting disease (CWD) from mule deer to cattle by the intracerebral route. Thirteen calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Three other calves were kept as uninoculated controls. The experiment was terminated 6 years after inoculation. During that time, abnormal prion protein (PrPres) was demonstrated in the central nervous system (CNS) of 5 cattle by both immunohistochemistry and Western blot. However, microscopic lesions suggestive of spongiform encephalopathy (SE) in the brains of these PrPres-positive animals were subtle in 3 …

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Bovine Tuberculosis Eradication: Uniform Methods And Rules, Effective January 1, 2005 Jan 2005

Bovine Tuberculosis Eradication: Uniform Methods And Rules, Effective January 1, 2005

Michigan Bovine Tuberculosis Bibliography and Database

These Uniform Methods and Rules (UM&R) are the minimum standards adopted and approved by the Deputy Administrator, Veterinary Services (VS), Animal and Plant Health Inspection Service (APHIS), on January 20, 2005. They were established for the maintenance of tuberculosis-free accredited herds of cattle and bison and the maintenance of State or zone status in the U.S. Department of Agriculture’s (USDA) tuberculosis eradication program.

These minimum standards do not preclude the adoption of more stringent standards by any State or zone.

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