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Articles 2851 - 2880 of 5204

Full-Text Articles in Medicine and Health Sciences

Clinical Research And Development Of Tuberculosis Diagnostics: Moving From Silos To Synergy, Payam Nahid, Peter S. Kim, Carlton A. Evans, David Alland, Michael Barer, Jane Diefenbach, Jerrold Ellner, Richard Hafner, Carol Dukes Hamilton, Michael F. Iademarco, Gregory Ireton, Michael E. Kimerling, Christian Lienhardt, William R. Mackenzie, Megan Murray, Mark D. Perkins, Jamie E. Posey, Teri Roberts, Christine Sizemore, Wendy S. Stevens, Laura Via, Sharon D. Williams, Wing Yew, Susan Swindells Jan 2012

Clinical Research And Development Of Tuberculosis Diagnostics: Moving From Silos To Synergy, Payam Nahid, Peter S. Kim, Carlton A. Evans, David Alland, Michael Barer, Jane Diefenbach, Jerrold Ellner, Richard Hafner, Carol Dukes Hamilton, Michael F. Iademarco, Gregory Ireton, Michael E. Kimerling, Christian Lienhardt, William R. Mackenzie, Megan Murray, Mark D. Perkins, Jamie E. Posey, Teri Roberts, Christine Sizemore, Wendy S. Stevens, Laura Via, Sharon D. Williams, Wing Yew, Susan Swindells

United States Public Health Resources

The development, evaluation, and implementation of new and improved diagnostics have been identified as critical needs by human immunodeficiency virus (HIV) and tuberculosis researchers and clinicians alike. These needs exist in international and domestic settings and in adult and pediatric populations. Experts in tuberculosis and HIV care, researchers, healthcare providers, public health experts, and industry representatives, as well as representatives of pertinent US federal agencies (Centers for Disease Control and Prevention, Food and Drug Administration, National Institutes of Health, United States Agency for International Development) assembled at a workshop proposed by the Diagnostics Working Group of the Federal Tuberculosis Taskforce …


The Use Of Low-Calorie Sweeteners By Children: Implications For Weight Management, John Foreyt, Ronald Kleinman, Rebecca Brown, Rachel Lindstrom Jan 2012

The Use Of Low-Calorie Sweeteners By Children: Implications For Weight Management, John Foreyt, Ronald Kleinman, Rebecca Brown, Rachel Lindstrom

United States Public Health Resources

The rise in pediatric obesity since the 1970s has been well established in the United States and is becoming a major concern worldwide. As a potential means to help slow the obesity epidemic, low-calorie sweeteners (LCS) have gained attention as dietary tools to assist in adherence to weight loss plans or prevention of excess weight gain. Observational studies tend to show positive correlations between LCS consumption and weight gain in children and adolescents. Although the data are intriguing, these epidemiologic studies do not establish that LCS cause weight gain, because there are likely many lifestyle and genetic differences between children …


Salmonella Enterica Serotype Enteritidis: Increasing Incidence Of Domestically Acquired Infections, Shua J. Chai, Patricia L. White, Sarah L. Lathrop, Suzanne M. Solghan, Carlota Medus, Beth Mcglinchey, Melissa Tobin-D'Angelo, Ruthanne Marcus, Barbara Mahon Jan 2012

Salmonella Enterica Serotype Enteritidis: Increasing Incidence Of Domestically Acquired Infections, Shua J. Chai, Patricia L. White, Sarah L. Lathrop, Suzanne M. Solghan, Carlota Medus, Beth Mcglinchey, Melissa Tobin-D'Angelo, Ruthanne Marcus, Barbara Mahon

United States Public Health Resources

Background. Salmonella enterica causes an estimated 1 million cases of domestically acquired foodborne illness in humans annually in the United States; Enteritidis (SE) is the most common serotype. Public health authorities, regulatory agencies, food producers, and food processors need accurate information about rates and changes in SE infection to implement and evaluate evidence-based control policies and practices.

Methods. We analyzed the incidence of human SE infection during 1996–2009 in the Foodborne Diseases Active Surveillance Network (FoodNet), an active, population-based surveillance system for laboratory-confirmed infections. We compared FoodNet incidence with passively collected data from complementary surveillance systems and with …


The Structure Of Posttraumatic Psychopathology In Veterans Attending Primary Care, David Forbes, Jon D. Elhai, Emma Lockwood, Mark Creamer, B. Christopher Frueh, Kathryn M. Magruder Jan 2012

The Structure Of Posttraumatic Psychopathology In Veterans Attending Primary Care, David Forbes, Jon D. Elhai, Emma Lockwood, Mark Creamer, B. Christopher Frueh, Kathryn M. Magruder

United States Public Health Resources

This study attempted to extend research indicating that posttraumatic stress disorder (PTSD) factors of Re-experiencing, Avoidance and Hyperarousal are more related to Fear/phobic disorders, while PTSD Dysphoria is more related to Anxious-Misery disorders. Trauma exposure, PTSD and comorbidity data for 668 veteran patients were analysed using confirmatory factor analyses and relative strengths of the relationships between PTSD factors and the Fear and Anxious-Misery factors were assessed. Combining Simms, Watson, and Doebbeling’s (2002) model of PTSD symptoms and Krueger’s (1999) Fear/Anxious Misery model of mood and anxiety disorders fit the data well. Contrary to previous research, PTSD Reexperiencing, Avoidance and Hyperarousal …


Trends In Total Laryngectomy In The Era Of Organ Preservation: A Population- Based Study, Patrick Tate Maddox, Louise Davies Jan 2012

Trends In Total Laryngectomy In The Era Of Organ Preservation: A Population- Based Study, Patrick Tate Maddox, Louise Davies

United States Public Health Resources

Objective. To describe time trends in total laryngectomy health services utilization across the United States, such as rates of surgery, cost, length of stay, and insurance payer, and to compare this to important milestones in recommendations for laryngeal cancer treatment.

Study Design. Population-based cohort study

Setting. Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) 1997-2008: stratified sample of all US hospital discharges.

Subjects and Methods. All patients with the principal procedure of complete laryngectomy. The unit of analysis was the discharge.

Results. Between 1997 and 2008, the number of laryngectomies done in the United States …


Women At War: Understanding How Women Veterans Cope With Combat And Military Sexual Trauma, Kristin M. Mattocks, Sally G. Haskell, Erin E. Krebs, Amy C. Justice, Elizabeth M. Yano, Cynthia Brandt Jan 2012

Women At War: Understanding How Women Veterans Cope With Combat And Military Sexual Trauma, Kristin M. Mattocks, Sally G. Haskell, Erin E. Krebs, Amy C. Justice, Elizabeth M. Yano, Cynthia Brandt

United States Public Health Resources

The wars in Iraq (Operation Iraqi Freedom, OIF) and Afghanistan (Operation Enduring Freedom, OEF) have engendered a growing population of US female veterans, with women now comprising 15% of active US duty military personnel. Women serving in the military come under direct fire and experience combatrelated injuries and trauma, and are also often subject to in-service sexual assaults and sexual harassment. However, little is known regarding howwomen veterans cope with these combat and military sexual trauma experiences once they return from deployment. To better understand their experiences, we conducted semi-structured interviews with nineteen OEF/OIF women veterans between JanuaryeNovember 2009. Women …


Factors Associated With Screening Or Treatment Initiation Among Male United States Veterans At Risk For Osteoporosis Fracture, Richard E. Nelson, Jonathan R. Nebeker, Brian C. Sauer, Joanne Lafleur Jan 2012

Factors Associated With Screening Or Treatment Initiation Among Male United States Veterans At Risk For Osteoporosis Fracture, Richard E. Nelson, Jonathan R. Nebeker, Brian C. Sauer, Joanne Lafleur

United States Public Health Resources

Male osteoporosis continues to be under-recognized and undertreated in men. An understanding of which factors cue clinicians about osteoporosis risk in men, and which do not, is needed to identify areas for improvement. This study sought to measure the association of a provider's recognition of osteoporosis with patient information constructs that are available at the time of each encounter. Using clinical and administrative data from the Veterans Health Administration system, we used a stepwise procedure to construct prognostic models for a combined outcome of osteoporosis diagnosis, treatment, or a bone mineral density (BMD) test order using time-varying covariates and Cox …


Β2 Adrenergic Receptor Agonists And Steroids Inhibit Cafo Dust-Mediated Bronchial Epithelial Inflammation In Vitro, D. J. Romberger, K. Palm, A. J. Heires, T. M. Nordgren, M. L. Toews, T. A. Wyatt Jan 2012

Β2 Adrenergic Receptor Agonists And Steroids Inhibit Cafo Dust-Mediated Bronchial Epithelial Inflammation In Vitro, D. J. Romberger, K. Palm, A. J. Heires, T. M. Nordgren, M. L. Toews, T. A. Wyatt

United States Public Health Resources

Rationale: Agricultural workers employed in concentrated animal feeding operations (CAFOs) are repeatedly exposed to aerosolized dust, and are susceptible to inflammatory lung diseases including COPD. Aqueous extracts of agricultural dust collected from swine CAFOs (HDE) have been shown to be potent inflammatory stimulators in human cells and in vivo mouse models. HDE exposure augments proinflammatory cytokine release, ICAM-1 expression, PKC activation, and lymphocyte and neutrophil adhesion to airway epithelial cells. Because 2 adrenergic receptor agonists (β-agonists) alone, and in combination with corticosteroids, have been used to treat COPD, we examined the ability of these agents to diminish the inflammatory …


Cytokine Responses In Whole Blood Assay In Veterans With Agriculture Work Exposures, J. D. J. Romberger, J. L. Meza, E.C. Chickris, A. J. Heires, R. M. Zotti-Pierce, T. D. Levan Jan 2012

Cytokine Responses In Whole Blood Assay In Veterans With Agriculture Work Exposures, J. D. J. Romberger, J. L. Meza, E.C. Chickris, A. J. Heires, R. M. Zotti-Pierce, T. D. Levan

United States Public Health Resources

RATIONALE: Agriculture exposures are associated with increased risk of chronic obstructive pulmonary disease (COPD). Endotoxin exposure in agricultural environments is associated with lung disease. Our objective was to evaluate responsiveness to endotoxin stimulation in an in vitro whole blood assay and its association with COPD in an agriculturally exposed cohort.

METHODS: Veterans with ≥ two years agricultural work exposure participated in this case-control study. Cases are veterans with COPD defined as FEV1/FVC ratio < 70% on spirometry post-bronchodilator. Controls did not have COPD as assessed by spirometry nor other significant lung conditions. Whole blood assay (WBA) was done with 2 ml heparinized blood mixed with 2 ml of media and stimulated with increasing doses of LPS (0 – 1 ng/ml). Samples were incubated at 37°C for 24 hours, centrifuged, supernatants harvested and frozen until assayed for cytokines by ELISA. Cytokine values were log transformed. Repeated measures ANOVA was used to examine the association between LPS dose and group (case or control) and the interaction of dose with group. All p values were adjusted for age.

RESULTS: There were 272 participants, 110 cases with COPD and 158 controls. Baseline demographics (gender, age, race) were similar between cases and controls. LPS-stimulated …


Scavenger Receptor A Activation Enhances Peptidoglycan-Stimulated Interleukin-8 Release In Bronchial Epithelium, J. P. Berger, K. L. Bailey, J. M. Devasure, D. J. Romberger, T. A. Wyatt Jan 2012

Scavenger Receptor A Activation Enhances Peptidoglycan-Stimulated Interleukin-8 Release In Bronchial Epithelium, J. P. Berger, K. L. Bailey, J. M. Devasure, D. J. Romberger, T. A. Wyatt

United States Public Health Resources

INTRODUCTION: The immune response to certain pathogens or cellular stressors is initiated and regulated by pattern recognition receptors of the innate immune system. Pattern recognition receptors are effective by utilizing either endocytic (Scavenger Receptors) or signaling receptors (Toll-like Receptors). It has been previously demonstrated that mouse dendritic cells deficient in scavenger receptor A (SRA) negatively regulated the immune response produced by Toll-like receptors when exposed to modified lipid proteins. Previously, we have shown that peptidoglycan contained in organic dust from swine barns stimulates pro-inflammatory cytokine release in bronchial epithelium. We hypothesized bronchial epithelial SRA would also have a regulatory …


Fish Oil And Indomethacin In Combination Potently Reduce Dyslipidemia And Hepatic Steatosis In Ldlr-/- Mice, Ganesan Murali, Ginger L. Milne, Corey Webb, Ann B. Stewart, Ryan P. Mcmillan, Brandon C. Lyle, Matthew W. Hulver, Viswanathan Saraswathi Jan 2012

Fish Oil And Indomethacin In Combination Potently Reduce Dyslipidemia And Hepatic Steatosis In Ldlr-/- Mice, Ganesan Murali, Ginger L. Milne, Corey Webb, Ann B. Stewart, Ryan P. Mcmillan, Brandon C. Lyle, Matthew W. Hulver, Viswanathan Saraswathi

United States Public Health Resources

Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known anti-inflammatory drugs, can enhance the anti-inflammatory and lipid-lowering effect of FO. LDLR-/- mice were fed a high fat diet supplemented with 6% olive oil or FO for 12 wk in the presence or absence of indomethacin (Indo, 6mg/liter drinking water). FO reduced plasma total cholesterol by 30% but in combination with Indo, exerted a greater decrease (44%). The reduction of liver cholesterol ester (CE) and triglycerides (TG) by FO (63% …


Annual Report To The Nation On The Status Of Cancer, 1975-2008, Featuring Cancers Associated With Excess Weight And Lack Of Sufficient Physical Activity, Christie Eheman, S. Jane Henley, Rachel Ballard-Barbash, Eric J. Jacobs, Maria J. Schymura, Anne-Michelle Noone, Liping Pan, Robert N. Anderson, Janet E. Fulton, Betsy A. Kohler, Ahmedin Jemal, Elizabeth Ward, Marcus Plescia, Lynn A. G. Ries, Brenda K. Edwards Jan 2012

Annual Report To The Nation On The Status Of Cancer, 1975-2008, Featuring Cancers Associated With Excess Weight And Lack Of Sufficient Physical Activity, Christie Eheman, S. Jane Henley, Rachel Ballard-Barbash, Eric J. Jacobs, Maria J. Schymura, Anne-Michelle Noone, Liping Pan, Robert N. Anderson, Janet E. Fulton, Betsy A. Kohler, Ahmedin Jemal, Elizabeth Ward, Marcus Plescia, Lynn A. G. Ries, Brenda K. Edwards

United States Public Health Resources

BACKGROUND: Annual updates on cancer occurrence and trends in the United States are provided through collaboration between the American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR). This year’s report highlights the increased cancer risk associated with excess weight (overweight or obesity) and lack of sufficient physical activity (<150 minutes of physical activity per week).

METHODS: Data on cancer incidence were obtained from the CDC, NCI, and NAACCR; data on cancer deaths were obtained from the CDC’s National Center for Health Statistics. Annual percent changes in …


The Association Between Depression And Anxiety And Use Of Oral Health Services And Tooth Loss, Catherine A. Okoro, Tara W. Strine, Paul I. Eke, Satvinder S. Dhingra, Lina S. Balluz Jan 2012

The Association Between Depression And Anxiety And Use Of Oral Health Services And Tooth Loss, Catherine A. Okoro, Tara W. Strine, Paul I. Eke, Satvinder S. Dhingra, Lina S. Balluz

United States Public Health Resources

Objective: The purpose of this study is to examine the associations among depression, anxiety, use of oral health services, and tooth loss.

Methods: Data were analysed for 80 486 noninstitutionalized adults in 16 states who participated in the 2008 Behavioral Risk Factor Surveillance System. Binomial and multinomial logistic regression analyses were used to estimate predicted marginals, adjusted prevalence ratios, adjusted odds ratios (AOR) and their 95% confidence intervals (CI).

Results: The unadjusted prevalence for use of oral health services in the past year was 73.1% [standard error (SE), 0.3%]. The unadjusted prevalence by level of tooth loss …


Business And Wealth Transfer In Nonmetropolitan Nebraska 2012 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, Odee Ingersoll, Shawn Kaskie Jan 2012

Business And Wealth Transfer In Nonmetropolitan Nebraska 2012 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, Odee Ingersoll, Shawn Kaskie

Rural Futures Institute: Publications

Includes

Executive Summary

Introduction

Businesses in the Community

Expected Number of Businesses in Local Community Five Years from Now by Community Size

Most Likely Outcome when Business Owner Leaves or Retires in Community

Business Exits and Transitions

Concern with Business Exits

Concern that Business Closings will Affect Ability to Get Needed Things by Occupation

Views of Community Strategies for Business Exits


Community Well-Being In Nonmetropolitan Nebraska 2012 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben Jan 2012

Community Well-Being In Nonmetropolitan Nebraska 2012 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben

Rural Futures Institute: Publications

Includes

Executive Summary

Trends in Community Ratings, 1996-2012

Community Change, 1996-2012

Expected Destination of Those Planning to Move: 1998-2012

Proportions of Respondents Very or Somewhat Satisfied with Each Service, 1997-2012

The Community and Its Attributes in 2012

Perceptions of Community Change by Community Size

Expected Community Change in Ten Years by Community Size

Satisfaction with Cellular Phone Service by Community Size

Difficulty or Ease of Leaving Community

Ease or Difficulty of Leaving Community by Length of Residence in Community

Feelings of Community Powerlessness by Community Size

Local Community Involvement Activities, 2002 and 2012

Distance from Goods and Services

Distance from …


Integrating Sexual Objectification With Object Versus Person Recognition: The Sexualized-Body-Inversion Hypothesis, Philippe Bernard, Sarah J. Gervais, Jill Allen, Sophie Campomizzi, Olivier Klein Jan 2012

Integrating Sexual Objectification With Object Versus Person Recognition: The Sexualized-Body-Inversion Hypothesis, Philippe Bernard, Sarah J. Gervais, Jill Allen, Sophie Campomizzi, Olivier Klein

Department of Psychology: Faculty Publications

In the study reported here, we tested the novel sexualized-body-inversion hypothesis. Integrating research and theory on objectification and person versus object recognition, we examined whether sexualized women, but not sexualized men, are recognized in the same way as objects are. According to objectification theory (Fredrickson & Roberts, 1997), female bodies are scrutinized and evaluated to a greater degree than male bodies are, which leads to sexual objectification of women. Defined as viewing or treating an individual as a sexualized body, or as sexualized body parts, available for satisfying the needs and desires of other people (Bartky, 1990), sexual objectification has …


Replicating Adenovirus-Simian Immunodeficiency Virus (Siv) Vectors Efficiently Prime Siv-Specific Systemic And Mucosal Immune Responses By Targeting Myeloid Dendritic Cells And Persisting In Rectal Macrophages, Regardless Of Immunization Route, L. Jean Patterson, Seraphin Kuate, Mara Daltabuit-Test, Qingsheng Li, Peng Xiao, Katherine Mckinnon, Janet Dipasquale, Anthony Cristillo, David Venzon, Ashley Haase, Marjorie Robert-Guroff Jan 2012

Replicating Adenovirus-Simian Immunodeficiency Virus (Siv) Vectors Efficiently Prime Siv-Specific Systemic And Mucosal Immune Responses By Targeting Myeloid Dendritic Cells And Persisting In Rectal Macrophages, Regardless Of Immunization Route, L. Jean Patterson, Seraphin Kuate, Mara Daltabuit-Test, Qingsheng Li, Peng Xiao, Katherine Mckinnon, Janet Dipasquale, Anthony Cristillo, David Venzon, Ashley Haase, Marjorie Robert-Guroff

United States Public Health Resources

Although priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, followed by HIV/SIV envelope boosting, has proven highly immunogenic, resulting in protection from SIV/simian-human immunodeficiency virus (SHIV) challenges, Ad5hr recombinant distribution, replication, and persistence have not been examined comprehensively in nonhuman primates. We utilized Ad5hr-green fluorescent protein and Ad5hr-SIV recombinants to track biodistribution and immunogenicity following mucosal priming of rhesus macaques by the intranasal/intratracheal, sublingual, vaginal, or rectal route. Ad recombinants administered by all routes initially targeted macrophages in bronchoalveolar lavage (BAL) fluid and rectal tissue, later extending to myeloid dendritic cells …


Program And Proceedings: Nebraska Academy Of Sciences 1880–2012, 132nd Anniversary Year, One Hundred-Twenty-Second Annual Meeting Jan 2012

Program And Proceedings: Nebraska Academy Of Sciences 1880–2012, 132nd Anniversary Year, One Hundred-Twenty-Second Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Applied Science and Technology

Biological and Medical Sciences

Nebraska Wesleyan University Health and Sciences Graduate School Fair

Aeronautics and Space Science, Poster Session

Maiben Memorial Lecture: "The Status of Nebraska's Native Aspen," "Buffalo" Bruce McIntosh, Western Nebraska Resources Council

Aeronautics

Anthropology

Biological and Medical Sciences

Chemistry and Physics

Collegiate Academy: Biology

Collegiate Academy: Chemistry and Physics

Earth Science

History/Philosophy of Science

Junior Academy, Senior High Competition

Teaching of Science and Math

Junior Academy, Junior High Competition


Siv Infection Induces Accumulation Of Plasmacytoid Dendritic Cells In The Gut Mucosa, R. Keith Reeves, Tristan I. Evans, Jacqueline Gillis, Fay E. Wong, Guobin Kang, Qingsheng Li, R. Paul Johnson Jan 2012

Siv Infection Induces Accumulation Of Plasmacytoid Dendritic Cells In The Gut Mucosa, R. Keith Reeves, Tristan I. Evans, Jacqueline Gillis, Fay E. Wong, Guobin Kang, Qingsheng Li, R. Paul Johnson

Nebraska Center for Virology: Faculty Publications

Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut—the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3-fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa.


Triticum Mosaic Poacevirus Enlists P1 Rather Than Hc-Pro To Suppress Rna Silencing-Mediated Host Defense, Satyanarayana Tatineni, Feng Qu, Ruhui Li, Thomas Jack Morris, Roy French Jan 2012

Triticum Mosaic Poacevirus Enlists P1 Rather Than Hc-Pro To Suppress Rna Silencing-Mediated Host Defense, Satyanarayana Tatineni, Feng Qu, Ruhui Li, Thomas Jack Morris, Roy French

Nebraska Center for Virology: Faculty Publications

Triticum mosaic virus (TriMV) is the type species of the newly established Poacevirus genus in the family Potyviridae. In this study, we demonstrate that in contrast to the helper component- proteinase (HC-Pro) of Potyvirus species, the P1 proteins of TriMV and Sugarcane steak mosaic poacevirus function in suppression of RNA silencing (SRS). TriMV P1 effectively suppressed silencing induced by single- or double-stranded RNAs (ss/ds RNAs), and disrupted the systemic spread of silencing signals at a step after silencing signal production. Interestingly, contrary to enhanced SRS activity of potyviral HC-Pro by co-expression with P1, the presence of TriMV HC-Pro reduced …


Identification Of Molecular Determinants From Moloney Leukemia Virus 10 Homolog (Mov10) Protein For Virion Packaging And Anti-Hiv-1 Activity, Aierken Abudu, Xiaojun Wang, Ying Dang, Tao Zhou, Shi-Hua Xiang, Yong -Hui Zheng Jan 2012

Identification Of Molecular Determinants From Moloney Leukemia Virus 10 Homolog (Mov10) Protein For Virion Packaging And Anti-Hiv-1 Activity, Aierken Abudu, Xiaojun Wang, Ying Dang, Tao Zhou, Shi-Hua Xiang, Yong -Hui Zheng

Nebraska Center for Virology: Faculty Publications

Background: MOV10 inhibits HIV-1 replication after being packaged.

Results: A Gag binding plus all but one of seven helicase domains are required for MOV10 packaging. Nearly all residues are required for anti-HIV-1 activity. Conclusion: Gag binding is not sufficient for MOV10 packaging, and multiple discontinuous domains regulate MOV10 activity.

Significance: These findings uncover a new packaging mechanism and provide new insights into MOV10 antiviral activity.


Anthropological Data Regarding The Adaptiveness Of Hebephilia, Raymond B. Hames, Ray Blanchard Jan 2012

Anthropological Data Regarding The Adaptiveness Of Hebephilia, Raymond B. Hames, Ray Blanchard

Department of Anthropology: Faculty Publications

Hebephilia is the sexual attraction to early pubertal children in Tanner Stages 2 and 3, generally ages 11 through 14.

The second author of this letter (R.B.), a member of the Paraphilias Subworkgroup of the Work Group on Sexual and Gender Identity Disorders for DSM-5, proposed a diagnostic entity for DSM-5 that resembles the ICD-10 model, but with a different name: Pedohebephilic Disorder. In the original proposal (Blanchard, 2010a), this disorder would have three subtypes: pedophilic, hebephilic, and pedohebephilic. In the current version of the proposal, which is still under consideration, the name has been changed to Pedophilic Disorder, in …


Electronic Health Records: Eliciting Behavioral Health Providers’ Beliefs [Brief Reports], Nancy C. Shank, Elizabeth Willborn, Lisa M. Pytlik Zillig, Harmonijoie Noel Jan 2012

Electronic Health Records: Eliciting Behavioral Health Providers’ Beliefs [Brief Reports], Nancy C. Shank, Elizabeth Willborn, Lisa M. Pytlik Zillig, Harmonijoie Noel

Nancy Shank Publications

Interviews with 32 community behavioral health providers elicited perceived benefits and barriers of using electronic health records. Themes identified were (a) quality of care, (b) privacy and security, and (c) delivery of services. Benefits to quality of care were mentioned by 100% of the providers, and barriers by 59% of providers. Barriers involving privacy and security concerns were mentioned by 100% of providers, and benefits by 22%. Barriers to delivery of services were mentioned by 97% of providers, and benefits by 66%. Most providers (81%) expressed overall positive support for electronic behavioral health records.


Artemisinin-Resistant Malaria: Research Challenges, Opportunities, And Public Health Implications, Rick M. Fairhurst, Gaurvika M. L. Nayyar, Joel G. Breman, Rachel Hallett, Jonathan Vennerstrom, Socheat Duong, Pascal Ringwald, Thomas E. Wellems, Christopher V. Plowe, Arjen M. Dondorp Jan 2012

Artemisinin-Resistant Malaria: Research Challenges, Opportunities, And Public Health Implications, Rick M. Fairhurst, Gaurvika M. L. Nayyar, Joel G. Breman, Rachel Hallett, Jonathan Vennerstrom, Socheat Duong, Pascal Ringwald, Thomas E. Wellems, Christopher V. Plowe, Arjen M. Dondorp

United States Public Health Resources

Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This …


Characterization Of Pasteurella Multocida Strains Isolated From Geese, Zsuzsanna Varga, Dmitriy V. Volokhov, Laszlo Stipkovits, Akos Thuma, Boglarka Sellyei, Tibor Magyar Jan 2012

Characterization Of Pasteurella Multocida Strains Isolated From Geese, Zsuzsanna Varga, Dmitriy V. Volokhov, Laszlo Stipkovits, Akos Thuma, Boglarka Sellyei, Tibor Magyar

United States Food and Drug Administration: Publications

Phenotypic and genotypic diversity of forty-two Pasteurella multocida isolates from geese were characterized by analysis of their capsular type, Heddleston serotype, biotype, fimbrial gene allele type, comparative outer membrane protein (OMP) electrophoresis patterns, and were analyzed using PCR for the presence of virulence-associated genes (toxA, tbpA, pfhA, hgbA, hgbB, nanH, nanB, fimA, hsf-1, and pmHAS). A sequence comparison of the thdF and rpoB housekeeping genes of twenty representative P. multocida strains from three different OMP groups demonstrated that seventeen strains were closely related phylogenetically to previously published strains of P. multocida subsp. multocida and P. multocida subsp. gallicida, and only …


Dynamics Of Envelope Evolution In Clade C Shiv-Infected Pig-Tailed Macaques During Disease Progression Analyzed By Ultra-Deep Pyrosequencing, For Yue Tso, Damien C. Tully, Sandra Gonzalez, Christopher Quince, On Ho, Patricia Polacino, Ruth M. Ruprecht, Shiu-Lok Hu, Charles Wood Jan 2012

Dynamics Of Envelope Evolution In Clade C Shiv-Infected Pig-Tailed Macaques During Disease Progression Analyzed By Ultra-Deep Pyrosequencing, For Yue Tso, Damien C. Tully, Sandra Gonzalez, Christopher Quince, On Ho, Patricia Polacino, Ruth M. Ruprecht, Shiu-Lok Hu, Charles Wood

Nebraska Center for Virology: Faculty Publications

Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) infection of nonhuman primate provides an ideal platform for such studies. A newly developed clade C SHIV, SHIV-1157ipd3N4, which was able to infect rhesus macaques, closely resembled primary HIV-1 in transmission and pathogenesis, was used to infect several pig-tailed macaques. One of the infected animals subsequently progressed to AIDS, whereas one remained a nonprogressor. The viral envelope evolution in the infected animals during disease progression was analyzed by a bioinformatics approach using ultra-deep …


Coxsackievirus B3 Infection Leads To The Generation Of Cardiac Myosin Heavy Chain-Α-Reactive Cd4 T Cells In A/J Mice, Arunakumar Gangaplara, Chandirasegaran Massilamany, Deborah M. Brown, Gustavo A. Delhon, Asit K. Pattnaik, Nora Chapman, Noel Rose, David J. Steffen, Jay Reddy Jan 2012

Coxsackievirus B3 Infection Leads To The Generation Of Cardiac Myosin Heavy Chain-Α-Reactive Cd4 T Cells In A/J Mice, Arunakumar Gangaplara, Chandirasegaran Massilamany, Deborah M. Brown, Gustavo A. Delhon, Asit K. Pattnaik, Nora Chapman, Noel Rose, David J. Steffen, Jay Reddy

Jay Reddy Publications

Enteroviruses like coxsackievirus B3 (CVB3) are common suspects in myocarditis/dilated cardiomyopathy patients. Autoimmunity has been proposed as an underlying mechanism, but direct evidence of its role is lacking. To delineate autoimmune response in CVB3 myocarditis, we used IAk dextramers for cardiac myosin heavy chain (Myhc)-α 334–352. We have demonstrated that myocarditis-susceptible A/J mice infected with CVB3 generate Myhc-α-reactive CD4 T cells and such a repertoire was absent in naïve mice as measured by proliferative response to Myhc-α 334–352 and IAk dextramer staining. We also detected Myhc-α 334–352 dextramer+ cells in the hearts of CVB3-infected mice. The autoreactive …


Strategic Discussions For Nebraska: Opportunities For Nebraska -- Food Scarcity, Mary Garbacz Jan 2012

Strategic Discussions For Nebraska: Opportunities For Nebraska -- Food Scarcity, Mary Garbacz

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Strategic Discussions for Nebraska is a program in the University of Nebraska-Lincoln Institute of Agriculture and Natural Resources that produces an annual publication called Opportunities for Nebraska, focusing on a different topic each year. The publication is produced in hard copy and also is available online at www.sdn.unl.edu.

The content for each publication is produced by UNL students enrolled in a Magazine Writing course each spring semester, taught by the SDN coordinator. Students conduct interviews with UNL researchers and write stories for inclusion in the publication. The interviews are captured on video and are edited into video montages, …


Latino Adolescent Adjustment: An Examination Of Cultural Values, Maria I. Iturbide Jan 2012

Latino Adolescent Adjustment: An Examination Of Cultural Values, Maria I. Iturbide

Department of Psychology: Dissertations, Theses, and Student Research

In the U.S., 22% of children under the age of 18 are Latino and 52% of Latino children have at least one parent who is foreign-born (Fry & Passel, 2009). Latinos are likely to experience acculturative strains associated with a range of negative outcomes such as academic underachievement. A mixed method sequential explanatory design was used to examine the protective effects of cultural factors that may ameliorate the negative effects of acculturative strains on psychological and academic adjustment.

The quantitative phase of the study examined whether biculturalism and ethnic identity would reduce the negative influence of acculturation strains on adjustment …


Evaluation Of Elevated Bait Trays For Attracting Blackbirds (Icteridae) In Central North Dakota, George M. Linz, Jamison B. Winter, William J. Bleier Jan 2012

Evaluation Of Elevated Bait Trays For Attracting Blackbirds (Icteridae) In Central North Dakota, George M. Linz, Jamison B. Winter, William J. Bleier

United States Department of Agriculture Wildlife Services: Staff Publications

Sunflower (Helianthus annuus L.) became an economically important crop in North Dakota in the 1970s, providing a major source of food for post-breeding blackbirds (Icteridae). Reducing local blackbird populations with rice grains treated with an avicide is one proposed alternative for reducing sunflower damage. In fall 2007 and 2008, we evaluated the idea of attracting blackbirds to rice-baited trays attached to wire cages supplied with live blackbirds. During our observations (1011 h), we saw 3888 birds, consisting of 25 species and 12 families, on the bait trays. Blackbirds made up 90.4% of the bird observations, whereas sparrows (Emberizidae) made …