Medicine and Health Sciences Commons^™

Dietitian’S Problem Solving Knowledge To Promote And Support Breastfeeding, Cassandra L. Dytrych

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

As a result of ongoing efforts in the U.S. to promote breastfeeding as the normal way to nourish an infant, breastfeeding initiation rates are higher than they have been in decades. As the experts on food and nutrition through the lifecycle, registered dietitians (RDs) should be knowledgeable to promote and support breastfeeding. It is not well known if RDs have this knowledge. The purpose of this study was to determine the current knowledge of RDs about breastfeeding, the types of professional opportunities RDs have to promote and support breastfeeding, and the level of education RDs have to deal with breastfeeding …

Psychotherapy Clients’ Online Behavior And Opinions Regarding Internet Searches Conducted By Therapists, Emily B. Gale

Department of Psychology: Dissertations, Theses, and Student Research

The Internet has become possibly the most popular medium to find information and communicate in our society. For the field of psychology, the Internet offers a new way to collect data and communicate with both study participants and, for practicing psychologists, possibly clients. Little is known, however, about the implications of interacting with clients online. The existing empirical studies in this area (DiLillo & Gale, 2011; Lehavot, Barnett, & Powers, 2010; Taylor et al., 2010) have focused on psychology graduate students’ actions online. These studies highlight the importance and paucity of research regarding the online behaviors of psychotherapy clients and …

Autism Spectrum Disorders In Hispanics And Non-Hispanics, Virginia Chaidez, Robin L. Hansen, Irva Hertz-Picciotto

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To compare differences in autism between Hispanics and non-Hispanics. We also examined the relationship between multiple language exposure and language function and scores of children. Methods: The Childhood Autism Risks from Genetics and the Environment (CHARGE) study is an ongoing population-based case-control study with children sampled (n = 1061) from three strata: those with autism (AU) or autism spectrum disorder (ASD); developmental delay (DD); or the general population (GP). Results: Non-Hispanic cases demonstrated higher cognitive composite scores for the Mullen Scales of Early Learning (MSEL). There were significant associations between multiple language exposure and MSEL subscales for receptive …

A Mixed Methods Approach To Food Safety Knowledge, Beliefs And Practices In Hispanic Families With Young Children In Nebraska, Kristen M. Stenger

College of Education and Human Sciences: Dissertations, Theses, and Student Research

This mixed methods study addresses food safety for Hispanic families with young children in Nebraska. A convergent mixed methods design was used, where qualitative and quantitative data were collected in parallel, analyzed separately and then merged in analysis and interpretation. A quantitative food safety knowledge survey (n=90, 52 from focus groups, 38 from piloting the survey), was used to assess the FightBac!™ concepts: Clean, Separate, Cook, Chill, and two additional concepts: foods that increase risk, and groups at increased risk. Qualitative focus groups explored food safety handling beliefs and practices through the lens of the Health Belief Model. Focus groups …

A Century And A Half Of Research On The Stable Fly, Stomoxys Calcitrans (L.) (Diptera: Muscidae), 1862-2011: An Annotated Bibliography, K. M. Kneeland, Steven R. Skoda, Jerome A. Hogsette, A. Y. Li, Jaime Molina-Ochoa, Kimberly Hutchinson Lohmeyer, John E. Foster

Department of Entomology: Faculty Publications

The stable fly, Stomoxys calcitrans, is a cosmopolitan pest of livestock, wild animals, pets, and humans. It is a primary pest of cattle in the United States, estimated to cause more than $1 billion in economic losses annually. It also causes dissension at the rural-urban interface and is a problem in recreation areas such as Florida beaches and the Great Lakes. Due to its pestiferous nature and painful bite, methods to control stable flies have been investigated for over a century. A large amount of research has been reported on stable fly biology, ecology, genetics, physiology, and vector competence. …

Microbial Co-Occurrence Relationships In The Human Microbiome, Karoline Faust, J. Fah Sathirapongsasuti, Jacques Izard, Dirk Gevers, Jeroen Raes, Curtis Huttenhower

Department of Food Science and Technology: Faculty Publications

The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important contributors to this variation. It is thus of interest to assess what relationships might exist among microbes and determine their underlying reasons. The initial Human Microbiome Project (HMP) cohort, comprising 239 individuals and 18 different microbial habitats, provides an unprecedented resource to detect, catalog, and analyze such relationships. Here, we applied an ensemble method based on multiple similarity measures in combination with generalized boosted linear models (GBLMs) to taxonomic marker (16S rRNA gene) profiles …

Structure, Function And Diversity Of The Healthy Human Microbiome, Curtis Huttenhower, Jacques Izard

Department of Food Science and Technology: Faculty Publications

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far. We found the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. …

All-Cause Gastroenteritis And Rotavirus-Coded Hospitalizations Among Us Children, 2000–2009, Rishi Desai, Aaron T. Curns, Claudia A. Steiner, Jacqueline E. Tate, Manish M. Patel, Umesh D. Parashar

United States Public Health Resources

Background. Rotavirus vaccine was recommended for US infants in 2006. We estimated baseline prevaccine burden and monitored postvaccine trends in gastroenteritis-coded and rotavirus-coded hospitalizations among US children.

Methods. We analyzed data from the State Inpatient Databases (SID) for 29–44 US states over a 10-year period (2000–2009) to calculate gastroenteritis and rotavirus-coded hospitalization rates by age group, sex, and region, among children <5 years of age. By extrapolating observed pre- and postvaccine gastroenteritis hospitalization rates to the US population <5 years and based on the 2009 cost of a diarrhea hospitalization, we estimated national reductions in diarrhea hospitalizations and associated treatment costs.

Results. The prevaccine (2000–2006) annual average gastroenteritis-coded hospitalization rate among children <5 years of age was 74 per 10 000 (annual range, 71–82 per 10 000), and declined to 51 and 50 per 10 000 in 2008 and 2009, respectively (P < .001). The prevaccine (2000–2006) annual average rotavirus-coded hospitalization rate among children <5 years of age was 15 per 10 000 (annual range, 13–18 per 10 000), and declined to 5 and 6 per 10 000 in 2008 and 2009, respectively (P < .001). The decreases in rotavirus-coded hospitalization rates in 2008 and 2009 compared with rates in prevaccine years were observed among all age groups and US regions. Nationally, during 2008 and 2009 combined, we estimated a reduction of approximately 77 000 diarrhea hospitalizations and approximately $242 million in hospital costs.

Conclusions. Since implementation of the US rota-virus vaccination program, a marked reduction in diarrhea hospitalizations and related hospital charges has occurred among US children.

Communication-Based Assessment Of Developmental Age For Young Children With Developmental Disabilities, Shari L. Deveney, Lesa Hoffman, Cynthia J. Cress

Department of Psychology: Faculty Publications

Purpose: In this study, the authors compared a multiple-domain strategy for assessing developmental age of young children with developmental disabilities who were at risk for long-term reliance on augmentative and alternative communication (AAC) with a communication-based strategy composed of receptive language and communication indices that may be less affected by physically challenging tasks than traditional developmental age scores.

Method: Participants were 42 children (age 9–27 months) with developmental disabilities and who were at risk for long-term reliance on AAC. Children were assessed longitudinally in their homes at 3 occasions over 18 months using multiple-domain and communication-based measures. Confirmatory factor analysis …

Chemistry-Dependent Adsorption Of Serum Proteins Onto Polyanhydride Microparticles Differentially Influences Dendritic Cell Uptake And Activation, Brenda R. Carrillo-Conde, Amanda E. Ramer-Tait, Michael J. Wannemeuhler, Balaji Narasimhan

Amanda Ramer-Tait Publications

The delivery of antigen-loaded microparticles to dendritic cells (DCs) may benefit from surface optimization of the microparticles themselves, thereby exploiting the material properties and introducing signals that mimic pathogens. Following in vivo administration microparticle surface characteristics are likely to be significantly modified as proteins are quickly adsorbed onto their surface. In this work we describe the chemistry-dependent serum protein adsorption patterns on polyanhydride particles and the implications for their molecular interactions with DCs. The enhanced expression of MHC II and CD40 on DCs after incubation with amphiphilic polyanhydride particles, and the increased secretion of IL-6, TNF-α, and IL-12p40 by hydrophobic …

Harvesting Murine Alveolar Macrophages And Evaluating Cellular Activation Induced By Polyanhydride Nanoparticles, Ana V. Chavez-Santoscoy, Lucas M. Huntlimer, Amanda E. Ramer-Tait, Michael J. Wannemeuhler, Balaji Narasimhan

Amanda Ramer-Tait Publications

Biodegradable nanoparticles have emerged as a versatile platform for the design and implementation of new intranasal vaccines against respiratory infectious diseases. Specifically, polyanhydride nanoparticles composed of the aliphatic sebacic acid (SA), the aromatic 1,6-bis(p-carboxyphenoxy)hexane (CPH), or the amphiphilic 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) display unique bulk and surface erosion kinetics and can be exploited to slowly release functional biomolecules (e.g. protein antigens, immunoglobulins, etc.) in vivo. These nanoparticles also possess intrinsic adjuvant activity, making them an excellent choice for a vaccine delivery platform.

In order to elucidate the mechanisms governing the activation of innate immunity following intranasal mucosal …

The Role Of Engagement Across Conceptually Distinct Treatment Elements For Social Anxiety Disorder, Timothy M. Emge

Department of Psychology: Dissertations, Theses, and Student Research

There are currently several efficacious treatments for social anxiety disorder (e.g. exposure therapy and cognitive therapy). Each of these treatments is thought to reduce symptoms of social anxiety by disrupting maintenance mechanisms of the disorder, yet mechanism of change research has not supported this view. The current study compared components from each therapy modality in order to better understand why symptoms reduce similarly between conceptually distinct treatments. Participants with high social anxiety were randomly assigned to give a speech with cognitive restructuring and engagement-enhancing procedures, cognitive preparation and video feedback, or a speech alone. Self-ratings of speech performance, confidence in …

Dimensions Of Individuals' Judgements About Sexual Attraction, Romantic Attachment, And Sexual Orientation, Luis F. Morales Knight

Department of Psychology: Dissertations, Theses, and Student Research

Despite 150 years of scientific interest in sexual orientation, contemporary investigators grapple with a number of serious difficulties. A precise, unified definition of sexual orientation appropriate for scientific use continues to elude researchers, most likely because there is still no single coherent theory of sexual orientation. This lack impedes research into the measurement of sexual orientation. Existing measurements of sexual orientation rely on partial or incompletely empirical research. The present study identified promising avenues for development of credible definitions, theories, and measurements of sexual orientation: (a) mate-selection tasks; (b) the idea that bisexually-identified individuals place a lower priority on partner …

Identification And Assessment Of Markers Of Biotin Status In Healthy Adults, Wei Kay Eng

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Human biotin requirements are unknown and the identification of reliable markers of biotin status is necessary to fill this knowledge gap. Here we used an outpatient feeding protocol to create states of biotin deficiency, sufficiency, and supplementation in 16 healthy men and women. Twenty possible markers of biotin status were assessed including the abundance of biotinylated carboxylases in lymphocytes, the expression of genes from biotin metabolism, and the urinary excretion of biotin and organic acids. Only the abundance of biotinylated 3-methylcrotonyl-CoA carboxylase (holo-MCC) and propionyl-CoA carboxylase (holo-PCC) allowed for distinguishing among all three levels of biotin intake. The urinary excretion …

Composition Of The Adult Digestive Tract Bacterial Microbiome Based On Seven Mouth Surfaces, Tonsils, Throat And Stool Samples, Nicola Segata, Susan Kinder Haake, Peter Mannon, Katherine P. Lemon, Levi Waldron, Dirk Gevers, Curtis Huttenhower, Jacques Izard

Department of Food Science and Technology: Faculty Publications

Background: To understand the relationship between our bacterial microbiome and health, it is essential to define the microbiome in the absence of disease. The digestive tract includes diverse habitats and hosts the human body’s greatest bacterial density. We describe the bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined metabolic potentials of four representative sites.

Results: The microbiota of these diverse habitats formed four groups based on similar community compositions: buccal mucosa, keratinized gingiva, hard palate; saliva, tongue, tonsils, throat; sub- and supra-gingival plaques; …

Metabolic Reconstruction For Metagenomic Data And Its Application To The Human Microbiome, Sahar Abubucker, Nicola Segata, Johannes Goll, Alyxandria M. Schubert, Jacques Izard, Brandi L. Cantarel, Beltran Rodriguez-Mueller, Jeremy Zucker, Mathangi Thiagarajan, Bernard Henrissat, Owen White, Scott T. Scott, Barbara Methé, Patrick D. Schloss, Dirk Gever, Makedonka Mitreva, Curtis Huttenhower

Department of Food Science and Technology: Faculty Publications

Microbial communities carry out the majority of the biochemical activity on the planet, and they play integral roles in processes including metabolism and immune homeostasis in the human microbiome. Shotgun sequencing of such communities’ metagenomes provides information complementary to organismal abundances from taxonomic markers, but the resulting data typically comprise short reads from hundreds of different organisms and are at best challenging to assemble comparably to single-organism genomes. Here, we describe an alternative approach to infer the functional and metabolic potential of a microbial community metagenome. We determined the gene families and pathways present or absent within a community, as …

Staff Perceptions Of Risk For Prison Rape Perpetration And Victimization, Valerie M. Gonsalves, Kate Walsh, Mario J. Scalora

Department of Psychology: Faculty Publications

Copyright © 2012 SAGE Publications, http://tpj.sagepub.com Used by permission.

Linking Outcomes From Peabody Picture Vocabulary Test Forms Using Item Response Models, Lesa Hoffman, Jonathan Templin, Mabel L. Rice

Department of Psychology: Faculty Publications

Purpose: The present work describes how vocabulary ability as assessed by 3 different forms of the Peabody Picture Vocabulary Test (PPVT; Dunn & Dunn, 1997) can be placed on a common latent metric through item response theory (IRT) modeling, by which valid comparisons of ability between samples or over time can then be made.

Method: Responses from 2,625 cases in a longitudinal study of 697 persons for 459 unique PPVT items (175 items from Peabody Picture Vocabulary Test—Revised [PPVT–R] Form M [Dunn & Dunn, 1981], 201 items from Peabody Picture Vocabulary Test—3 [PPVT–3] Form A [Dunn & Dunn, 1997], and …

Stress, Coping And Suicide Ideation In Chinese College Students, Xiaoyun Zhang, Haiping Wang, Yan Ruth Xia, Xiaohong Liu, Eunju Jung

Department of Child, Youth, and Family Studies: Faculty Publications

The study was to examine 1) whether stress and coping styles could significantly predict the probability of suicide ideation; 2) and whether coping styles were mediators or moderators on the association between life stress and suicide ideation. The survey was conducted in a sample of 671 Chinese college students. Approximately twenty percent students reported having suicide ideation. Life stress, active coping styles, and passive coping styles all had independent effect on the probability of suicide ideation. Passive coping styles, especially fantasizing, mediated the relation between life stress and suicide ideation. Moderation hypotheses were not supported. Implications of the findings and …

Book Review: Dream Of Ding Village By Yan Lianke, Mike Frick

China Beat Blog: Archive 2008-2012

Unsurprisingly, the Chinese government levied a “three nos” ban—no sales, no distribution, and no promotion—against Dream of Ding Village after its publication in 2005. Though the storytelling relies heavily on dream sequences, Yan takes little poetic license when exposing the depth of the state’s culpability in spreading HIV among poor, medically-naïve farmers. He is just as uncompromising when detailing how officials denied responsibility for the ensuing AIDS epidemic, even as they profited from its human tragedy. No one in Ding Village receives medical care, mental health counseling, food assistance, or a chance to hold the blood heads legally accountable. Cast …

Evaluation Of Pneumonia Virus Of Mice As A Possible Human Pathogen, Linda G. Brock, Ruth A. Karron, Christine D. Krempl, Peter L. Collins, Ursula J. Buchholz

United States Public Health Resources

Pneumonia virus of mice (PVM), a relative of human respiratory syncytial virus (RSV), causes respiratory disease in mice. There is serologic evidence suggesting widespread exposure of humans to PVM. To investigate replication in primates, African green monkeys (AGM) and rhesus macaques (n=4) were inoculated with PVM by the respiratory route. Virus was shed intermittently at low levels by a subset of animals, suggesting poor permissiveness. PVM efficiently replicated in cultured human cells and inhibited the type I interferon (IFN) response in these cells. This suggests that poor replication in nonhuman primates was not due to a general nonpermissiveness …

Genome-Wide Mirnaprofiling Of Mantle Cell Lymphoma Reveals A Distinct Subgroup With Poor Prognosis, Javeed Iqbal, Yulei Shen, Yanyan Liu, Kai Fu, Elaine S. Jaffe, Cuiling Liu, Zhongfeng Liu, Cynthia M. Lachel, Karen Deffenbacher, Timothy C. Greiner, Julie M. Vose, Sharathkumar Bhagavathi, Louis M. Staudt, Lisa Rimsza, Andreas Rosenwald, German Ott, Jan Delabie, Elias Campo, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, Randy D. Gascoyne, James O. Armitage, Dennis D. Weisenburger, Timothy W. Mckeithan, Wing C. Chan

United States Public Health Resources

miRNA deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL). Using a high-throughput quantitative real-time PCR platform, we performed miRNA profiling on cyclin D1–positive MCL (n = 30) and cyclin D1–negative MCL (n =7) and compared them with small lymphocytic leukemia/ lymphoma (n =12), aggressive B-cell lymphomas (n =138), normal B-cell subsets, and stromal cells.We identified a 19-miRNA classifier that included 6 up-regulated miRNAs and 13 down regulated miRNA that was able to distinguish MCL from other aggressive lymphomas. Some of the up-regulated miRNAs are highly expressed in naive B cells. This miRNAclassifier …

Effectiveness Of Supported Employment For Veterans With Spinal Cord Injuries: Results From A Randomized Multisite Study, Lisa Ottomanelli, Lance L. Goetz, Alina Suris, Charles Mcgeough, Patricia L. Sinnott, Rich Toscano, Scott D. Barnett, Daisha J. Cipher, Lisa M. Lind, Thomas M. Dixon, Sally Ann Holmes, Anthony J. Kerrigan, Florian P. Thomas

United States Public Health Resources

Ottomanelli L, Goetz LL, Suris A, McGeough C, Sinnott PL, Toscano R, Barnett SD, Cipher DJ, Lind LM, Dixon TM, Holmes SA, Kerrigan AJ, Thomas FP. Effectiveness of supported employment for veterans with spinal cord injuries: results from a randomized multisite study.

Objective: To examine whether supported employment (SE) is more effective than treatment as usual (TAU) in returning veterans to competitive employment after spinal cord injury (SCI).

Design: Prospective, randomized, controlled, multisite trial of SE versus TAU for vocational issues with 12 months of follow-up data.

Setting: SCI centers in the Veterans Health Administration.

Participants: …

Spatiotemporal Coupling Of The Tongue In Amyotrophic Lateral Sclerosis, Mili S. Kuruvilla, Jordan R. Green, Yana Yunusova, Kathy Hanford

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: The primary aim of the investigation was to identify deficits in spatiotemporal coupling between tongue regions in amyotrophic lateral sclerosis (ALS). The relations between disease-related changes in tongue movement patterns and speech intelligibility were also determined.

Methods: The authors recorded word productions from 11 individuals with ALS with mild, moderate, and severe dysarthria using an x-ray microbeam during word productions. A coupling index based on sliding window covariance was used to determine disease-related changes in the coupling between the tongue regions across each word.

Results: The results indicated decreased spatiotemporal coupling of mid-posterior tongue regions and reduced tongue speed …

Improving Health Care Quality And Safety: The Development And Assessment Of Laparoscopic Surgery Instrumentation, Practices And Procedures, Bernadette Mccrory

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Adverse events due to medical errors are a leading cause of death in the United States exceeding the mortality rates of motor vehicle accidents, breast cancer and AIDS. Improvements can and should be made to reduce the rates of preventable surgical errors since they account for nearly half of all adverse events within hospitals. Although minimally invasive surgery has proven patient benefits such as reduced postoperative pain and hospital stay, its operative environment imposes substantial physical and cognitive strain on the surgeon increasing the risk of error. In order to mitigate errors and protect patients, a multidisciplinary approach was taken …

Cell-Mediated Immunity In Porcine Reproductive And Respiratory Syndrome Virus, Rajeshwari Parida

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Porcine reproductive and respiratory syndrome virus is a significant swine pathogen which exhibits considerable sequence diversity. In an attempt to identify highly conserved T-cell epitopes contained in proteins of this virus, we examined heptadecamer peptides spanning the sequence of the PRRSV nonstructural proteins 9, 10 and 11, all of them are highly conserved, for their ability to elicit a recall proliferative and interferon-gamma response in peripheral blood mononuclear cells obtained from pigs immunized against the type-II PRRSV strain FL-12. These studies led to the identification of seven peptides, two from each NSP 9 and NSP 10 and, three from NSP …

Modeling Of The Efficacy And Effectiveness Of Escherichia Coli O157:H7 Pre-Harvest Interventions, Amanda R. Vogstad

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Shiga toxin-producing Escherichia coli O157:H7 (STEC O157) is one of the leading causes of hemolytic uremic syndrome in humans. Reducing the prevalence of STEC O157 in live cattle may reduce ground beef prevalence and subsequent human illness. Type III secreted protein vaccines (TTSP) reduce fecal shedding of STEC O157 in cattle. However, pre-harvest vaccines have yet to be adopted by the beef industry. The objectives of this thesis were to 1) conduct a meta-analysis to test factors effecting efficacy of a 3-dose regimen TTSP vaccine product, and 2) use stochastic simulation to model the usefulness of preharvest control measures. In …

Breakfast Consumption Habits Of Youth Living In Low Income Neighborhoods In A Large Three County Metropolitan Area, Elijah Dacy

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Purpose: The purpose of this study was to identify youth attitudes, frequency of, and barriers for breakfast consumption and the use of available nutrition programs by youth living in poverty or food insecure households in a large three county metropolitan area. Methods: A phone survey was developed and tested in order to collect information on breakfast consumption habits and attitudes of children, targeted as food insecure. There were no incentives for persons to participate in the survey and all information gathered was kept in a secure place at the Center for Human Nutrition. Participants who were allowed to …

Love Means Never Having To Say You're Sorry, But What About Malpractice? A Look At Verbal And Nonverbal Factors Affecting Perceptions Of Apologies In A Medical Malpractice Case, Sarah Thimsen

Department of Psychology: Dissertations, Theses, and Student Research

Apologies are part of daily life and occur in a variety of contexts. A large body of literature on the effects of apologies indicated that apologies have a positive effect – those receiving apologies have more positive views of the transgressor (e.g., Bornstein, Rung, & Miller, 2002; Goei, Roberty, Meyer, & Carlyle, 1997; Robbennolt, 2003; Sitkin & Beis, 1993; Takaku, 2000). An area of emerging research in the realm of apologies is in the area of medical malpractice. The research presented here sought to expand on the field of apologies, specifically by examining the effects of an apology in a …

Molecular Distinctions Between Pediatric And Adult Mature B-Cell Non-Hodgkin Lymphomas Identified Through Genomic Profiling, Karen Deffenbacher, Javeed Iqbal, Warren Sanger, Yulei Shen, Cynthia Lachel, Zhongfeng Liu, Yanyan Liu, Megan Lim, Sherrie Perkins, Kai Fu, Lynette Smith, James Lynch, Louis Staudt, Lisa M. Rimsza, Elaine Jaffe, Andreas Rosenwald, German Ott, Jan Delabie, Elias Campo, Randy Gascoyne, Mitchell Cairo, Dennis Weisenburger, Timothy Greiner, Thomas Gross, Wing Chan

United States Public Health Resources

Burkitt lymphoma (BL) predominates in pediatric patients, whereas diffuse large B-cell lymphoma (DLBCL) is uncommon. In contrast to adults, BL and DLBCL are treated similarly in children and both entities have superior outcomes in children compared with adults. Gene expression profiling (GEP) and miRNA expression profiling clearly differentiated pediatric DLBCL from BL, forming distinct clusters regardless of patient age. However, pathway analysis of GEP data identified minor differences between corresponding pediatric and adult tumors. Predominance (6:1) of the germinal center B-cell subtype to activated B-cell subtype was found among pediatric DLBCL. Two cases were molecularly classified as primary mediastinal B-cell …