Medicine and Health Sciences Commons^™

Local Initiatives In Preventing Coronavirus Based On Health Policy Perceptive, Dumilah Ayuningtyas, Misnaniarti Misnaniarti, Siti Khodijah Parinduri, Fitria Aryani Susanti, Ni Nyoman Dwi Sutrisnawati,

Journal of Indonesian Health Policy and Administration

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Effectiveness Of Large-Scale Social Restrictions (Psbb) Toward The New Normal Era During Covid-19 Outbreak: A Mini Policy Review, Helen Andriani

Journal of Indonesian Health Policy and Administration

The government of Indonesia has not used lockdown or quarantine as an option to tackle the spread of Coronavirus, as the impact of lockdown on small communities in the informal sector that lives from daily income will be severe. Alternatively, the government is enforcing Large-Scale Social Restrictions (Pembatasan Sosial Berskala Besar or "PSBB") to respond to the state of emergency in public health. Starting in June 2020, the government has implemented transitional PSBB in some red zone areas, including the capital Jakarta and East Java province, despite the surge in case numbers. This paper aims to investigate the effectiveness of …

Evaluation Of Potential Drug Interaction Of Analgesic In Cancer Patient Receiving Palliative Care In Dharmais Cancer Hospital, Eme Stepani Sitepu, Atika Wahyu Puspitasari, Nuriza Ulul Azmi, Lila Nilam Sari

Pharmaceutical Sciences and Research

Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed …

Anti-Proliferative Effects Of A Coumarin Benjaminin On Four Human Cancer Cell Lines, Siau Hui Mah, Soek Sin Teh, Ahmad Azri Fitri Ismail, Gwendoline Cheng Lian Ee

Pharmaceutical Sciences and Research

Cancer is a major health issue around the globe. Chemotherapy and radiation therapy are no longer the standard treatments for patients as these remedies lead to many adverse effects. Thus, the development of alternative effective drugs from lead compounds, especially natural products is necessary. This study aimed to isolate cytotoxic phytochemical constituents from a plant Calophyllum inophyllum, which has been used as traditional medicine since ancient time. The root of C. inophyllum was extracted and subjected for phytochemical constituent isolation. A coumarin, benjaminin (1) was isolated successfully from the chloroform extract and its structural elucidation was performed by spectroscopy analyses …

Ace Inhibitory Activity And Functional Group Analysis Of Solvent- Partitioned Fractions Of Eleusine Indica, Jade Celon Cometa, Liahona Faith Roldan Mancol, Anthony Nalzaro Yen, Joanne Katherine Talens Manlusoc

Pharmaceutical Sciences and Research

Eleusine indica Linn. Gaerth or Indian goose grass has been widely used as an alternative natural anti-hypertensive agent. However, the rationale behind this mechanism is still unknown. The purpose of this study is to confirm the presence of functional groups that may be responsible for its ACE inhibitory activity and its possible synergism. Each solvent-portioned fraction was analyzed by FTIR, individual ACE inhibitory activity, and combination of fractions. FTIR results of solvent- partitioned fractions revealed that O-H and C-H stretches were present in all fractions. In addition to this, C-O and C=O groups were also present in all fractions except …

Assessment Of Depression Among Older Adults Staying In Old Home Care In Klang, Malaysia, Muhammad Qamar, Nurul Zahirah, Sohail Ahmad

Pharmaceutical Sciences and Research

Mental disorders such as depression are widespread, often underdiagnosed, and usually inappropriately treated. The early recognition of factors that may promote depression with the help of depression screening aid can help to plan better care for the patient. Therefore, this study aimed to determine the depression prevalence among the older adults staying in old home care, to explore any association and differences of depression across various socio-demographic variables, and to study the predictors of depression among study subjects. A cross-sectional study was conducted with a convenience sample of 141 elderly by using the validated tool. The study instrument was divided …

An Exploration Of Electrospun Fibers Containing Drug-Cyclodextrin Inclusion Complexes, Fatimah Fatimah, Zeynep Aytac, Tamer Uyar, George Pasparakis, Gareth R. Williams

Pharmaceutical Sciences and Research

A series of new core-shell fibers were developed containing anticancer drugs (5-fluorouracil or ferulic acid) and their cyclodextrin inclusion complexes, with a gadolinium-based magnetic resonance imaging (MRI) contrast agent. These were prepared by electrospinning, a simple method for producing ultra-fine fibers through the application of a strong electrostatic force on a polymer solution. The shell of the fibers was formed from Eudragit S100, and the drugs were loaded in the core. Scanning electron microscopy images showed the formation of smooth ribbon-like fibers, with diameters ranging from 1.4 to 5.1 μm, and transmission electron microscopy reveals a transparent interface between the …

Interaction Of Thymidine With Sodium Bis(2-Ethylhexyl) Sulfosuccinate In Alcohol And Water: Studies With Uv-Vis Technique, Indu M. Paudel, Ajaya Bhattarai

Pharmaceutical Sciences and Research

The accurate measurement of thymidine absorbance in the presence of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in ethanol and water systems at room temperature by UV-vis technique has been reported. The AOT concentrations varied from 0.0005 to 0.014 [mol/L] in ethanol whereas from 0.0002 to 0.042 [mol/L] in water. The concentration of thymidine was 0.0073 [mol/L] during UV-vis spectrum registration. The thymidine spectrum was examined in the presence of AOT concentration. Using a statistical method of non-linear regression (NLREG), thymidine binding and thymidine distribution constants were evaluated. A noticeable decrease in thymidine absorbance in the presence of AOT concentration was shown in …

Formulasi Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk) Sebagai Sediaan Antiinflamasi, Nining Sugihartini, Syauqul Jannah, Tedjo Yuwono

Pharmaceutical Sciences and Research

The development of anti-inflammatory gel of Moringa oleifera leaf extract has been performed. This study aimed to determine the physical properties, irritation index and anti-inflammatory activity of gel with various concentration of Moringa oleifera leaf extract. The extract was obtained by maceration method using ethanol 70%. The extracts were formulated in a gel with a concentration of 3%, 6%, 9% by using Carbopol 940 as gelling agent. The gel was evaluated for its physical properties (viscosity, pH, spreadability, adhesivity), irritation index with rabbit test animals and anti-inflammatory activity with mice test animals based on epidermal thickness parameters. The test results …

Profil Terapi Antihipertensi Dan Antihiperlipidemia Terhadap Fungsi Ginjal Pasien Diabetes Melitus Tipe 2 Dengan Komplikasi Penyakit Ginjal Kronis Di Rsup Dr. Hasan Sadikin, Fitri Rachmaini, Lia Amalia, Cherry Rahayu

Pharmaceutical Sciences and Research

Chronic Kidney Disease (CKD) complication increases the risk of morbidity and mortality in type 2 diabetes mellitus (DMT2) patients. The presence of hypertension and dyslipidemia as comorbidity increases the risk of macrovascular and microvascular complications and further adding to the list of drugs used. Management of this comorbidity is essential to prevent cardiovascular events and minimize kidney damage. This study aimed to evaluate therapeutic profile of antihypertensive and antihyperlipidemia drugs towards kidney function in DMT2 patients with CKD complication at Dr. Hasan Sadikin Hospital. Study was done by using a prospective single cohort design with consecutive sampling technique and obtained …

Development Of Ethanolic Extract Of Pinang Masak Jambi (Areca Catechu L.) As A Modulator Of Doxorubicin Cytotoxic Effect In Breast Cancer Therapy, Fitrianingsih Fitrianingsih, Indri Maharini, Diah Tri Utami

Pharmaceutical Sciences and Research

Doxorubicin is one of the chemotherapy agents that is often used in breast cancer therapy. Phenomenon of breast cancer cell resistance to chemotherapy agents has been traced to the molecular level. The development of compounds that can overcome drug resistance chemotherapy needs to be continuously developed, especially agents with specific molecular targets, namely P-glycoprotein (Pgp), NFkB, cyclin, and cyclin-dependent kinase (CDK). Another alternative is the combination of chemotherapy agents with chemopreventive agents (co-chemotherapy) to reduce side effects and increase sensitivity of cancer cells. Doxorubicin is often used in breast cancer therapy. This study was performed to determine the effect of …

Encapsulation Of Temulawak Extract By Using Nanocrystalline Cassava And Sago Starches And Maltodextrin, Titi Candra Sunarti, Fatimah J. Pasaribu, Christina Winarti

Pharmaceutical Sciences and Research

This study was conducted to evaluate the performance of Curcuma zanthorrhiza crude extract after encapsulated in nanocrystalline starch, and to investigate the effect of the ratio of nanocrystalline starches and maltodextrin; and the effect of concentration of temulawak extract on nanocapsule characteristics, as well as encapsulation effect on the stability of antioxidant activity. Preparation of nanocrystalline starch was conducted by using lintnerization and ethanol precipitation of cassava and sago starches. Nanocrystalline starch and maltodextrin were used as matrices with the ratio varied from 25:75, 50:50, and 75:25. The mixture of temulawak extract and matrices were homogenized and spray dried. Nanocapsules …

Caries Prevalence And Severity In Immature Permanent First Molar Teeth In Sanliurfa City, Turkey, Ahmet Aras, Mehmet Sinan Dogan

Journal of Dentistry Indonesia

The prevalence of dental caries, a major public health problem in high-income countries, is gradually increasing in many low- and middle-income countries. The aim of this study is to evaluate the prevalence and severity of caries in the immature permanent first molars (PFMs) of children aged 7–9 years. Methods: This work is a retrospective analysis of caries in immature PFMs as observed from the panoramic radiographs of patients aged 7–9 years who presented to the pediatric clinic. The mean number of decayed, missing, or filled teeth (DMFT) and caries severity of immature PFMs were assessed. Results: A total of 3,112 …

Demographic And Clinical Profile Of Gingival Oral Lichen Planus In A Group Of Thai Individuals, Pissacha Daroonpan, Ruchadaporn Kaomongkolgit, Weeraya Tantanapornkul, Jadesada Palasuk

Journal of Dentistry Indonesia

Objective: This study aimed to determine the clinical profile of the gingival lesions of oral lichen planus (OLP) in a group of Thai patients. Methods: The dental records of 67 patients were reviewed. Results: In this study, 51 (76.1%) women and 16 (23.9%) men with a female-to-male ratio of 3.2:1 were included. The average age of patients with OLP was 56.0 ± 12.5 years (ranged = 20–81 years). Furthermore, 52 (77.6%) patients had a history of systemic diseases, and hypertension was predominant. All the patients presented with symptomatic OLP. Multiple OLP lesions were observed in 56 (83.6%) …

Evaluation Of The Relation Between Impacted Mandibular Third Molar Classification And Inferior Alveolar Canal, Sinan Yasin Ertem, Halil Anlar

Journal of Dentistry Indonesia

Objective: The development, eruption, and proximity of mandibular third molars with the inferior alveolar canal are highly variable. The classification of mandibular third molars and their relationship with the inferior alveolar canal were discussed. Methods: A total of 1,024 orthopantomograms (OPGs) from 422 male patients and 602 female patients were examined. The position of the mandibular third molars and their proximity to the inferior alveolar canal were evaluated. Results: Mandibular third molars were observed in 652 (63.67%) of the 1,024 OPGs. According to the Winter’s classification, the most common position of third molars was the vertical position …

Health-Related Anxiety In The Management Of Oral Soreness In An Hivseropositive Patient, Masita Mandasari, Zulvia Oktanida Syarif, Febrina Rahmayanti

Journal of Dentistry Indonesia

The number of people living with HIV (PLHIV) has been increasing since the first known case in the early 1980s. However, PLHIV can also experience comorbidities, such as health anxiety. In the oral cavity, anxiety is often associated with the etiology of parafunctional habits. Anxiety can be measured using self-administered instruments, such as the Hospital Anxiety and Depression Scale (HADS) and Short-Health Anxiety Inventory (SHAI), which is specifically used in the medical setting. Objectives: We are describing a case of HIV positive patient with health anxiety who presented to the oral medicine clinic in our hospital with a complaint of …

Differential Diagnosis And Histopathological Analysis Of Localized Gingival Overgrowths: Study Of 218 Cases From Northeast Thailand, Lordjie Marr Morilla, Ajiravudh Subarnbhesaj, Poramaporn Klanrit

Journal of Dentistry Indonesia

Localized gingival overgrowths (LGOs) are relatively common clinical findings. These lesions can be associated with chronic irritation, infections, or they can represent benign or malignant tumors that can either be primary or metastatic. The etiology of these lesions is multifactorial, but the most prevalent cause is reactive hyperplasia and inflammation induced by dental plaque. Objective: This study presents the prevalence of LGOs in Northeast Thailand and identifies the most common LGOs in the region. Methods: A series of 218 LGO cases was studied. Results: Pyogenic granuloma (PG), gingival squamous cell carcinoma (GSCC), and peripheral ossifying fibroma (POF) were the three …

Effect Of Acid Etching And Er:Yag Laser Enamel Conditioning On The Microleakage Of Glass Carbomer Fissure Sealants, Neslihan Ozveren, Yesim Sesen Uslu, Nazmiye Donmez

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the effects of Er:YAG laser used alone or in combination with acid etching as surface conditioners on the microleakage of a glass carbomer fissure sealant for permanent molar teeth.

Methods: Forty sound human permanent molar teeth were randomly divided into four experimental groups based on enamel etching methods: group I, no surface conditioning; group II, 37% phosphoric acid etching; group III, Er:YAG laser etching; and group IV, sequential laser etching and acid etching. After surface conditioning procedures were conducted, the teeth were sealed with a glass carbomer seal. The teeth were subjected …

Evaluation Of Clinical Single Dental Implants Made Between 2013 And 2017, Zozan Erdoğmuş

Journal of Dentistry Indonesia

Objective: This retrospective study aimed to determine the profile of patients who underwent single tooth implants between 2013 and 1017 and to evaluate long-term follow-up and success. Methods: The results of 79 patients who underwent single dental intra-bone dental implantation in Diyarbakır Oral and Dental Health Hospital between 2013 and 2017 were evaluated separately in terms of gender, age, implanted area and number, systemic diseases affecting implant health, and missing implants. Results: In this study, single tooth implants were evaluated in 79 patients with a mean age of 39.55 years in men and 30.44 years in women. …

Oral Health And Related Behavior Of Children Aged 9–12 With Attention Deficit Hyperactivity Disorder In Tron District, Thailand, Duangruethai Khobkham, Kanyarat Korwanich, Narumanas Korwanich

Journal of Dentistry Indonesia

Attention deficit hyperactivity disorder (ADHD) is a common biobehavioral childhood disorder that leads to significant behavioral problems that affect everyday life. Objective: This study aimed to compare oral health and oral health behaviors among children with and without ADHD. Methods: The study included 105 children aged 9–12 years with ADHD and 105 age-, gender-, and family income-matched children without ADHD. Clinical data as caries, periodontal health, and traumatic dental injuries were recorded by calibrated examiners. All parents of the children completed questionnaires about the oral health behaviors of their children by a single interview. Data were compared using Chi-square test, …

Management Of Atypical Symmetrical Ankylosis Of Maxillary Deciduous First Molars With Permanent Successors: A Single Case Report, Kemal Gulduren, Aylin İslam

Journal of Dentistry Indonesia

Dentoalveolar ankylosis is the union between the tooth root and the dentoalveolar bone. Clinically, the affected tooth is unsuccessful to erupt, exhibits an infraocclusal position within the dentoalveolar arch, elicits a metallic sound on percussion, and has reduced or absent mobility. Objective: This single case report illustrates the management of idiopathically ankylosed maxillary deciduous first molars. Case report: The patient was a 6-year-old female with maxillary deciduous first molars in infraocclusal position due to idiopathic ankylosis. The ankylosed deciduous teeth were monitored regularly. After a 27-month follow-up, the infraocclusion became severe. No vertical deficiencies in other alveolar regions were detected. …

Erupted Compound Odontoma Associated With Missing Tooth: A Rare Case Report, Weeraya Tantanapornkul, Ruchadaporn Kaomongkolgit, Sirilawan Tohnak, Lalitkorn Promma, Soranan Chantarangsu

Journal of Dentistry Indonesia

Odontomas are one of the most frequently found odontogenic tumors that consist of dental tissues. Odontomas have been classified into two types: compound and complex odontomas. They are usually discovered on routine radiographic examination. In rare cases, the odontoma erupt into the oral cavity, called an erupted odontoma. The first case was published in 1980, and since then, there have been not more than 50 cases being reported in the literature. Most of the reported cases are erupted complex odontoma. This case report represents a rare case of an erupted compound odontoma in a young patient who came with the …

Evaluasi Formatif Program Rehabilitasi Sosial Bagi Korban Perdagangan Anak(Studi Kasus Program Rehabilitasi Sosial Rumah Faye Batam), Ranggi Lukfi Aprilianzah, Wisni Bantarti

Jurnal Ilmu Kesejahteraan Sosial

This research is about the evaluation of social rehabilitation program for children trafficking victims conducted by Rumah Faye Batam, which is generally aimed to restore the social functions of the victims. The thesis is formative-evaluative research using a qualitative approach specified to elaborate on the implementation of the program, and also to identify and analyze the supporting factors and the constraints as a foundation of the program development. The result of the research shows that in the implementation of social rehabilitation programs at Rumah Faye, there are 7 stages which include various activities that refer to the flow of services …

Analisis Perencanaan Kebijakan Jaminan Kesehatan Nasional Dari Aspek Kepesertaan Di Kementerian Ppn/Bappenas, Feby Oldistra, Sari Viciawati Machdum

Jurnal Ilmu Kesejahteraan Sosial

National Health Insurance (JKN) is one of the policies to support the implementation of social development programs in Indonesia. This is in accordance with the mandate of the 1945 Constitution, where the state provided social protection to achieve social justice. One of the determining factors for the success of the JKN program participation aspect. The SJSN Law of 2004 binds citizens to participate in this program without exception. JKN was first implemented in 2014 with coverage target is 95% of population until 2019. But in its development, up to 2020 the coverage of membership is 82.7%. This study aims to …

Peran Pemerintah Dalam Mengatasi Permasalahan Kerawanan Sosial Di Wilayah Perbatasan Darat Indonesia, Kania Saraswati Harisoesyanti, Getar Hati, Ni Luh Putu Maitra Agastya

Jurnal Ilmu Kesejahteraan Sosial

No abstract provided.

Pemberdayaan Perempuan Dalam Kewirausahaan Sosial(Studi Kasus Waroeng Hijau, Ancol), Dien Yudithadewi, Bonifasius Parikesit, Rini Sudarmanti

Jurnal Ilmu Kesejahteraan Sosial

This research focuses on social entrepreneurship called Waroeng Hijau, which was initiated by one of the Regional Owned Enterprises since 2008. Waroeng Hijau is a women's empowerment program to address social issues in the Pademangan Sub-district, North Jakarta. This study uses a persuasive case approach (Siggelkow, 2007) to see the institutional structure or business model of social entrepreneurship that supports women's empowerment. The data collection process is carried out through literature review and interviews with relevant stakeholders. The results of the study stated that the innovative management model and funding, equality, and mutual cooperation became elements of empowerment that support …

A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose.

Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using the Statistical Package for the Social Sciences …

Peran Yayasan Kehati Dalam Program Prakarsa Lintasanhijau Halimun Salak, Marisca Wulansari, Indra Lestari Fawzi

Jurnal Ilmu Kesejahteraan Sosial

This study describes a Corporate Social Responsibility (CSR) program conducted by Star Energy Geothermal Salak, Ltd. in collaboration with the KEHATI Foundation in a program entitled Green Coridor Initatives Halimun Salak. This study aims to look at type of CSR governance, the role of the KEHATI in CSR activities as well as opportunities, obstacle and challenges in the Green Coridor Initiaves Halimun Salak. This is a qualitative research with a case study design using purposive sampling techniques. Data mining was carried out with a semi-structured in-depth interview with representatives of the Star Energy Geothermal Salak, Ltd., representatives of the KEHATI …

Obesity Is Associated With Depression In Malaysian Schoolchildren: A Cross-Sectional Study, Mohd Said Nurumal, Rohulizzat Zainal Abidin, Wisam Nabeel Ibrahim, Muhammad Lokman Md Isa, Muhammad Kamil Che Hasan

Makara Journal of Health Research

Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity and depression among schoolchildren in Kuantan.

Methods: This cross-sectional study was conducted in three different primary schools in Kuantan by purposive sampling. With consent from their parents/guardians, participants were given a self-administered questionnaire. Demographics and anthropometric measurement data were self-reported on the basis of the school records. Furthermore, body mass index was calculated. Data were analyzed using SPSS version 20.0, and chi-square and correlation tests were conducted for the variables.

Results: Among the 300 schoolchildren …

Caregiver Burden From Caring For Dependent Elderly In Yangon, The Republic Of The Union Of Myanmar, May Zun Naing, Sein Yaw May, Min Htike Aung

Makara Journal of Health Research

Background: Elderly population and well-being of those are emerging as major challenges for families and communities. This study aimed to identify caregiving burden among caregivers who care for dependent elderly.

Methods: A cross sectional descriptive study was conducted in Tharkayta Township, Yangon, Myanmar. Total 200 caregivers were selected applying multi-stage sampling method and structured questionnaires were used to collect data. Dependent score of elderly was assessed by using Barthel Index of activities of daily living (ADL) and assessment of caregiver burden through Zarit Burden Interview.

Results: The results showed that over one fifth of caregivers 21.5% had …