Medicine and Health Sciences Commons^™

Clinical Framework For Quality Improvement Of Cancer Cachexia., Clara Granda-Cameron, Mary Pat Lynch

College of Nursing Faculty Papers & Presentations

The objective of this article is to introduce the Clinical Framework for Quality Improvement of Cancer Cachexia (Cachexia Care Framework) as a tool to demonstrate the relevance of integrating the clinical components of cancer cachexia and the organizational strategies of a cancer institution on the quality of patient care and delivery of services throughout the cancer cachexia continuum. The data sources included peer-reviewed literature relevant to cancer cachexia and quality cancer care, and the authors' expertise. The Cachexia Care Framework results from a combination of the international consensus definition of cancer cachexia, the Institute of Medicine report Ensuring Quality Cancer …

Treatment-Related Decisional Conflict, Quality Of Life, And Comorbidity In Older Adults With Cancer., Jeannette M. Kates

College of Nursing Faculty Papers & Presentations

Objective: The present study aims to examine the relationships between and among cancer treatment-related decisional conflict, quality of life, and comorbidity in older adults with cancer.

Methods: A convenience sample of 200 older adults was recruited from outpatient medical oncology and radiation oncology practices in the northeastern United States. A cross-sectional, descriptive, correlational study design was used employing a survey method. Survey instruments included the Decisional Conflict scale (DCS) (with five subscales, including informed, values clarity, support, uncertainty, and effective decision); Self-administered comorbidity questionnaire (SCQ); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (including five function …

Larotrectinib Efficacy And Safety In Trk Fusion Cancer: An Expanded Clinical Dataset Showing Consistency In An Age And Tumor Agnostic Approach, U. N. Lassen, C. M. Albert, S. Kummar, C. M. Van Tilburg, S. G. Dubois, B. Geoerger, L. Mascarenhas, N. Federman, R. J. Schilder, F. Doz, J. D. Berlin, D. Y. Oh, S. S. Bielack, R. Mcdermott, D. S. Tan, S. Cruickshank, N. C. Ku, M. C. Cox, A. Drilon, D. S. Hong

Department of Medical Oncology Faculty Papers

Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19^thFeb 2018.

Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials …

Nci-Match Arms N & P: Phase Ii Study Of Pi3k Beta Inhibitor Gsk2636771 In Patients (Pts) With Cancers (Ca) With Pten Mutation/Deletion (Mut/Del) Or Pten Protein Loss, F. Janku, O. Jegede, S. L. Puhalla, P. Konstantinopoulos, F. Meric-Bernstam, E. P. Mitchell, J. A. Zwiebel, L. M. Mcshane, S. Li, L. V. Rubinstein, L. A. Doyle, D. Patton, B. A. Conley, P. J. O'Dwyer, L. N. Harris, C. Arteaga, P. M. Williams, S. R. Hamilton, A. P. Chen, K. T. Flaherty

Department of Medical Oncology Faculty Papers

Background: The NCI-MATCH trial is the largest national study (1173 sites) for ptswith relapsed/ refractory solid tumors, lymphomas and myeloma, which assigns tar-geted therapies based on individual tumor molecular alterations detected using theadapted Oncomine AmpliSeq panel (143 genes) and immunohistochemistry (IHC).We hypothesized that patients with PTEN-deficient cancers enrolled to Arms N and Pmay benefit from treatment with the PI3K beta-selective inhibitor GSK2636771.

Methods: Eligibility: relapsed/refractory ca, good end-organ function, and ECOG PS ≤ 1. Pts were screened for molecular alterations by centralized testing on fresh tumor biopsy and had deleterious PTEN mut/del without loss of expression (Arm N) or complete …

Pan-Squamous Genomic Profiling Stratified By Anatomic Tumor Site And Viral Association, M. Montesion, C. H. Chung, E. S. Sokol, S. A. Khan, H. Kang, L. A. Albacker, J. M. Johnson, G. M. Frampton, V. A. Miller, J. S. Ross, S. M. Ali

Department of Medical Oncology Faculty Papers

Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.

Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from …

Androgen Decline And Outcome In Castration Resistant Prostate Cancer(Mcrpc) Patients Treated With Docetaxel (Doc), Prednisone1/-Bevacizumab (B), C. J. Ryan, S. Dutta, W. Kelly, M. J. Morris, M-E. Taplin, S. Halabi

Department of Medical Oncology Faculty Papers

No abstract provided.

A Word From The Writing Team (October 2018), Jennifer Wilson, Ms, Els, Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Writing Lessons from Ted-Ed
• WHYY's Maiken Scott on Communicating Science
• Paywall: The Business of Scholarship

In Vitro Transport Of Methotrexate By Drosophila Multidrug Resistance-Associated Protein., Agnes Karasik, András Váradi, Flóra Szeri

Department of Dermatology and Cutaneous Biology Faculty Papers

Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of physiological metabolites and endo or xenobiotics, by their primary active transport across biological membranes. The substrate specificity and tissue distribution of these promiscuous human ABC transporters show a high degree of redundancy, providing robustness to these key physiological and pharmacological processes, such as the elimination of toxins, e.g. methotrexate from the body. A similar network of proteins capable of transporting methotrexate has been …

Epidemiology Of Moderate Alcohol Consumption And Breast Cancer: Association Or Causation?, Samir Zakhari, Jan B. Hoek

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Epidemiological studies have been used to show associations between modifiable lifestyle habits and the incidence of breast cancer. Among such factors, a history of alcohol use has been reported in multiple studies and meta-analyses over the past decades. However, associative epidemiological studies that were interpreted as evidence that even moderate alcohol consumption increases breast cancer incidence have been controversial. In this review, we consider the literature on the relationship between moderate or heavy alcohol use, both in possible biological mechanisms and in variations in susceptibility due to genetic or epigenetic factors. We argue that there is a need to incorporate …

Intestinal Barrier Tightening By A Cell-Penetrating Antibody To Bin1, A Candidate Target For Immunotherapy Of Ulcerative Colitis., Sunil Thomas, Kevther Hoxha, Walker Alexander, John Gilligan, Rima Dilbarova, Kelly Whittaker, Andrew Kossenkov, George C. Prendergast, James M. Mullin

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by recruitment of lymphocytes and neutrophils into the lamina propria. Based on genetic evidence that attenuation of the bridging integrator 1 (Bin1) gene can limit UC pathogenicity in animals, we have explored Bin1 targeting as a therapeutic option. Early feasibility studies in the dextran sodium sulfate mouse model of experimental colitis showed that administration of a cell-penetrating Bin1 monoclonal antibody (Bin1 mAb 99D) …

Neuroprotective Role Of Phytochemicals., Bharath Kumar Velmurugan, Baskaran Rathinasamy, Bharathi Priya Lohanathan, Varadharajan Thiyagarajan, Ching-Feng Weng

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Neurodegenerative diseases are normally distinguished as disorders with loss of neurons. Various compounds are being tested to treat neurodegenerative diseases (NDs) but they possess solitary symptomatic advantages with numerous side effects. Accumulative studies have been conducted to validate the benefit of phytochemicals to treat neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). In this present review we explored the potential efficacy of phytochemicals such as epigallocatechin-3-galate, berberin, curcumin, resveratrol, quercetin and limonoids against the most common NDs, including Alzheimer's disease (AD) and Parkinson's disease (PD). The beneficial potentials of these phytochemicals have been demonstrated by evidence-based but more …

Neighborhood Socials In South Philadelphia, Cambria Graham, Khadijah Pearson, Tytisha Harris

Nexus Maximus

Our project focuses on the lack of community in the South Philadelphia area and the high crime rates that are a result of this. We propose a monthly social event to be hosted at the parks and rec centers that are being revitalized by the state. We will start a sponsorship with Amazon who now owns Whole Foods as well as Aldi’s to promote healthy eating as well as provide food for the events.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local …

Cross Like A Boss, Ezana Ceman, Madeleine Scuderi, Brandi Davis, Syming Cottrell, Aryna Lysak

Nexus Maximus

"Cross Like a Boss" is an innovative solution to addressing pedestrian safety in South Philadelphia through policy changes. Included in the campaign is an RFID chip scanner card located at every major pedestrian crash hotspot which (1) allows users such as older adults, persons with disabilities, and children to have longer time crossing the street and (2) turn on audio options saying the word "Walk" in different languages corresponding to the major demographics of South Philadelphia. In addition, our new crosswalk policies involve a button for LED flashing lights along the crosswalk which alerts drivers in advance that there is …

Track My Trip, Katie Taylor, Charlotte Calderwood, Anish Bachu, Chase Fike, Danielle Samson

Nexus Maximus

We came up with a smart phone app to promote more physical activity which incorporates a reward scheme. This in turn helps to benefit local businesses.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful ways that benefit and protect individuals and society. The team project …

Success In The Streets Of Kensington, Melanie Perkins, Lindsay Wratcher, Halie Finke, Friederike Stock

Nexus Maximus

The third day of Nexus Maximus was spent working on our poster and getting our final ideas together to present the pitch to our audience. We all worked side by side in one of the DEC classrooms working on putting our thoughts into bullet points and developing the graphics for the board. My group member and I went to the poster workshop and got inspired to create the board layout. We wanted to keep the board as simple as possible with easy to read graphics and bullet points so that the viewer could easily follow our process and understand what …

Estuary: Mobile Support Service, D'Vine Savage, Kerwin Dasque, Laina Posner, Nhan Dung, Lily Postus, Arynn Pratt, Ayana Curtis

Nexus Maximus

Estuary: Mobile Support Service is a company that provides the Kensington community with the essentials to maintain and sustain overall health. We provide clean needles, food, water, clothing, and information/resources to help individuals with addiction, unemployment, housing etc. Our vision is to collaborate with several organizations within the Philadelphia area, such as Philabundance, and medical centers to provide the community with the best care.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with …

A Bag For A Bag, Nahye Kim, Gahyun Kim, Jasmyne Chester, Teagen Hay

Nexus Maximus

A sustainable self-sufficiency cycle for the homeless population in Kensington suffering from food insecurity and beyond.

The problem of food insecurity of the homeless will be improved, while increasing level of the public hygiene, sense of community, and self-sufficiency extent of the homeless beyond basic survival needs.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams …

Champ: Choosing Healthy Active Moving Play, Melanie Goldstein, Mica Lai, Omri Faroul, Valerie Leonard, Caroline Mccarthy, Suki Ghumman

Nexus Maximus

CHAMP is an afterschool program to get kids to become more active and healthy. The money raised will be used to fix the playground and make the area safer for children to play.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful ways that benefit and …

Growing Garden, Stan Kim, Lon'yea Ellis, Rhouleisha Thompson, Kristen Tekel

Nexus Maximus

To make space efficient garden system to have more green spaces through out the area.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful ways that benefit and protect individuals and society. The team project work will be supplemented with workshops on innovation, entrepreneurship, and content …

New Life, Madison Cotellese, Jahkiya Jack, Devaughn Lambert, Hammad Chaudhry, Mardochee Mallory

Nexus Maximus

Our final project is a drug rehabilitation facility in South Philadelphia. It highlights the problems of current facilities and proposes solutions to them.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful ways that benefit and protect individuals and society. The team project work will be …

Signs Of Trust, Samantha Barreto, Sylvie Abookire, Ronak Pansara, Wiebke Muehlhoff, Anthony Cho

Nexus Maximus

Signs of Trust is a service that provides the homeless with the choice of designing their own signs that is formatted to be trustworthy and honest. Passerby would be able to give to the homeless, by scanning the QR code on the signs, and selecting a gift card option that would given to the homeless by the service.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content …

Philly N' Me, Chi Hoo Hwang, Christopher Cherestal, Mackenzie Malcolm, Hannah Fitzpatrick, Michael Griffith

Nexus Maximus

Our purpose was to increase the awareness of education opportunities, for the under-privileged youth in the city Philadelphia. To do this, we have created a program which uses our holistic approach, focusing on creating a well-rounded student.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful …

Fresh Express, Timothy Skill, Alaina Mclhenney, Minji Hong, Chinmay Joshi, Witali Brianzew, Abby Garrity, Taegun Park

Nexus Maximus

Our project culminated with the decision to create Fresh Express. We began the project searching to find the best way to help end food insecurity in Philadelphia but specifically in Center City. Our food truck solution will help to create a healthier lifestyle for those directly in Center City and eventually throughout all of Philadelphia.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the …

Lnp Mediators For Posterity, Yinelia De La Cruz, Stephen Adasonla, Kieara Martin, Yi Soo Hahm, Jaymi Phillips, Holly Spring

Nexus Maximus

We have decided to tackle substance abuse in Lower North Philadelphia by eliminating the stigma around mental health in low income communities. By preventing drug usage in teen and young adult mental awareness, we can combat issues like suicide and the opioid epidemic. Using mediators by partnering with university students we can offer positive role models into the school system, while also offering internships and residency opportunities.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will …

Infastructure Revitalizing Community, Kyle Hanson, Caitlin Hagan, Jessica Trio, Mariah Cadzow, Adie Tierney, Jihye Jang

Nexus Maximus

Transforming an unused tunnel once used to hold a railroad into a package delivery system to deliver packages into Center City Philadelphia, the heart of the city, with minimal time waste and traffic blockage. Using foot and bike transportation to handle the "last mile issue". Lastly, in conjunction with the tunnel restructure,we are also proposing a city policy to limit large delivery trucks in center city during peak hours.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project …

What's Cooking?, Jake Isaac, Jessica Overpeck, Alisha Chacko, Kristina Kosztyo, Tuomas Tapper

Nexus Maximus

We decided to focus on a mobile solution to food insecurity and food deserts in Lower North Philadelphia. The approach will use education, cooking, and access to affordable whole foods. We created a business model for our mobile solution and this included many aspects, such as the problem, statistics, the solution, key partners, key activities, cost structure, revenue streams, future plans, etc.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on …

Happy Mind, Bailey Bourgeois, Erica Jacobs, Allison Wisneski, Amanda Torres, Antii Makkonen

Nexus Maximus

Center City is home to a vast majority of overworked 30 year old's with limited social lives and high stress levels which causes mental depletion and higher anxiety. Our solution to this problem is a mindfulness app for mobile phones that this specific group can participate in. The app would not only give you advice on your commute to work, but also give you invites to nearby social events and discounts to a number of stores in the area.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health …

Phil Like Playing?, José Ignacio Saavedra, Amanda &. Alanoud, Louise Gamble, Maureen Sledge

Nexus Maximus

Through researching issues within central Philadelphia we decided we need to improve the health and overall well-being of the community members. In doing this we found that within the Center City, 56.3% of the population are made up of single adults, with the majority living alone.

They also have 65.8% of the population working in white collar jobs. These situations consist of long working hours which decrease the percentage in social interaction. This can also lead to other issues such as mental health, where stress levels are high.

Our solution to combat the problem is to create a smartphone app …

Fish Bowl, Joseph Goggin, James Fang, Sam Orente, Jessica Horton, Alyssa Milione

Nexus Maximus

Our idea was to try to bring the people of Fishtown together by hosting events that appeal to all ages.

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities to leverage that data in meaningful ways that benefit and protect individuals and society. The team project work will be supplemented with workshops …

Philagreen: "Buy Green. Give Green. Live Green", Irene Cooper, Will Bender, Victor Wright, Chelsea Nwanne, Vannessa Njoo

Nexus Maximus

We will use green roofs to reduce levels of air pollution in Philadelphia, while simultaneously working to improve the lives of low-income Philadelphians through the donation of a green roof. Our program “Live One. Give One.” prices property owners based on yearly income

Nexus Maximus V

The 2018 Challenge: "Improving Lives Through Healthy Communities" Teams will evaluate and seek innovation that supports the health and well-being of specific local community populations. The team’s project work will be supplemented with workshops on innovation, entrepreneurship, and content relevant to the theme, delivered by experts throughout the weekend.

Teams will also explore opportunities …