Medicine and Health Sciences Commons^™

The Review - Summer 2000

Jefferson Review

IN THIS ISSUE

• 1 - Message From The Dean
• 2 - Laboratory Sciences Now Has More Options Than Any Other LS Program In The Country
• 2 - Nursing Expands Master’s Speciality Tracks
• 2 - Online And CD-ROM Courses: The Wave Of The Future?
• 3 - Nuclear Medicine Technology Enhances Image Of DI Department
• 3 - Foundation Doubles Support Of Scholarship Fund At CHP
• 4 - Alumni Relations Office Update: Rockin’ Good Times 5 Commencement 2000
• 5 - Byrne Recognized For Significant Contributions To College And Community
• 6 - Message From Alumni President
• 7 - Alumni Update
• 8 - College Notes

Development And Validation Of A Questionnaire To Evaluate Patient Satisfaction With Diabetes Disease Management, Lisa E. Paddock, J J. Veloski, Mary Lou Chatterton, Felicia O. Gevirtz, David B. Nash

CRMEHC Faculty Papers

OBJECTIVE: To develop a reliable and valid questionnaire to measure patient satisfaction with diabetes disease management programs.

RESEARCH DESIGN AND METHODS: Questions related to structure, process, and outcomes were categorized into 14 domains defining the essential elements of diabetes disease management. Health professionals confirmed the content validity. Face validity was established by a patient focus group. The questionnaire was mailed to 711 patients with diabetes who participated in a disease management program. To reduce the number of questionnaire items, a principal components analysis was performed using a varimax rotation. The Scree test was used to select significant components. To further …

Evaluations Of The Effectiveness Of A Web-Based Graduate Epidemiology Course, Molly A. Rose, Anthony J. Frisby, Michael D. Hamlin, Susan S. Jones

College of Nursing Faculty Papers & Presentations

An online epidemiology course was developed, implemented, and evaluated for graduate nursing students through the collaborative efforts of nursing faculty and information, education, and instructional design staff of the library at a health sciences university. This epidemiology course is a core curriculum course for graduate nursing students. The course was piloted with 14 students (one student in Romania); the initial online offering ran concurrently with a traditional classroom section. Extensive evaluation data were collected and analyzed to compare the effectiveness of the classroom and distance-learning formats. Areas of evaluation included objective measures, such as midterm and final examination scores and …

Long-Term Prevention Of Renal Insufficiency, Excess Matrix Gene Expression, And Glomerular Mesangial Matrix Expansion By Treatment With Monoclonal Antitransforming Growth Factor-Ss Antibody In Db/Db Diabetic Mice , Fuad N. Ziyadeh, Brenda B. Hoffman, Dong Cheol Han, M. Carmen Iglesias-De La Cruz, Soon Won Hong, Motohide Isono, Sheldon Chen, Tracy A. Mcgowan, Kumar Sharma

Department of Medicine Faculty Papers

Emerging evidence suggests that transforming growth factor-(TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-antibody (αT) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy and increased matrix mRNA. To establish that overactivity of the renal TGF-system mediates the functional and structural changes of the more advanced stages of nephropathy, we tested whether chronic administration of αT prevents renal insufficiency and glomerulosclerosis in the db/db mouse, model of type 2 diabetes that develops overt nephropathy. Diabetic db/db mice and nondiabetic db/m littermates were treated intraperitoneally with α or control IgG, …

Jefferson Alumni Bulletin – Volume Xlix, Number 3, June 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 3, June 2000 Synergy of clinical skills and behavioral medicine, page 4 African-American students at Jefferson, page 8 Competency based training: a new paradigm?, page 15 An answer on acute respiratory distress syndrome, page 17 FHIT gene implicated in many types of tumors, page 17 Pinpointing genetics of hereditary colorectal cancer, page 19 Phil Marone’57: associate Dean for Alumni relations, page 25

Evaluating The Sensitivity Of The Nanostrong Ncounter® Analysis System To Determine Gene Expression Changes Associated With Chemotherapy Treatment, Katerina Dukleska, Md, Christopher W. Schultz, Bs, Mahsa Zarei, Phd, David Mckeown, Md, Charles J. Yeo, Md, Jonathan Brody, Phd, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease with a 5-year survival of 8% for all stages combined (Siegel RL et al.). Currently, it’s the third leading cause of cancer-related deaths in the United States and by 2020 it is projected to become the second leading cause (Rahib L, et al).
• The poor prognosis in PDA is in part due to the limited therapies that are currently available.
• This highlights the importance of high-throughput technologies for gene expression analyses and drug screens.
• A recently developed NanoString Technologies nCounter® analysis system, an example of high-throughput technology, utilizes a color-coded barcode …

2000 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Membrane Cholesterol Content Modulates Activation Of Volume-Regulated Anion Current In Bovine Endothelial Cells., I Levitan, A E Christian, T N Tulenko, G H Rothblat

Department of Biochemistry and Molecular Biology Faculty Papers

Activation of volume-regulated anion current (VRAC) plays a key role in the maintenance of cellular volume homeostasis. The mechanisms, however, that regulate VRAC activity are not fully understood. We have examined whether VRAC activation is modulated by the cholesterol content of the membrane bilayer. The cholesterol content of bovine aortic endothelial cells was increased by two independent methods: (a) exposure to a methyl-beta-cyclodextrin saturated with cholesterol, or (b) exposure to cholesterol-enriched lipid dispersions. Enrichment of bovine aortic endothelial cells with cholesterol resulted in a suppression of VRAC activation in response to a mild osmotic gradient, but not to a strong …

Ubinuclein, A Novel Nuclear Protein Interacting With Cellular And Viral Transcription Factors., S Aho, M Buisson, T Pajunen, Y W Ryoo, J F Giot, H Gruffat, A Sergeant, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

The major target tissues for Epstein-Barr virus (EBV) infection are B lymphocytes and epithelial cells of the oropharyngeal zone. The product of the EBV BZLF1 early gene, EB1, a member of the basic leucine-zipper family of transcription factors, interacts with both viral and cellular promoters and transcription factors, modulating the reactivation of latent EBV infection. Here, we characterize a novel cellular protein interacting with the basic domains of EB1 and c-Jun, and competing of their binding to the AP1 consensus site. The transcript is present in a wide variety of human adult, fetal, and tumor tissues, and the protein is …

The Pl(A2) Polymorphism Of Integrin Beta(3) Enhances Outside-In Signaling And Adhesive Functions., K Vinod Vijayan, Pascal J. Goldschmidt-Clermont, Christine Roos, Paul F. Bray

Cardeza Foundation for Hematologic Research

Genetic factors are believed to influence the development of arterial thromboses. Because integrin alpha(IIb)beta(3) plays a crucial role in thrombus formation, we analyzed receptor adhesive properties using Chinese hamster ovary and human kidney embryonal 293 cells overexpressing the Pl(A1) or Pl(A2) polymorphic forms of alpha(IIb)beta(3). Soluble fibrinogen binding was no different between Pl(A1) and Pl(A2) cells, either in a resting state or when alpha(IIb)beta(3) was activated with anti-LIBS6. Pl(A1) and Pl(A2) cells bound equivalently to immobilized fibronectin. In contrast, significantly more Pl(A2) cells bound to immobilized fibrinogen in an alpha(IIb)beta(3)-dependent manner than did Pl(A1) cells. Disruption of the actin cytoskeleton …

Single-Channel Properties In Endoplasmic Reticulum Membrane Of Recombinant Type 3 Inositol Trisphosphate Receptor., D O Mak, S Mcbride, V Raghuram, Y Yue, Suresh K. Joseph, J K Foskett

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is an intracellular Ca(2+)-release channel localized in endoplasmic reticulum (ER) with a central role in complex Ca(2+) signaling in most cell types. A family of InsP(3)Rs encoded by several genes has been identified with different primary sequences, subcellular locations, variable ratios of expression, and heteromultimer formation. This diversity suggests that cells require distinct InsP(3)Rs, but the functional correlates of this diversity are largely unknown. Lacking are single-channel recordings of the recombinant type 3 receptor (InsP(3)R-3), a widely expressed isoform also implicated in plasma membrane Ca(2+) influx and apoptosis. Here, we describe functional expression and single-channel …

Jefferson Alumni Bulletin – Volume Xlix, Number 2, March 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 2, March 2000 Integrative medicine: Broadening the mainstream, page 4 Orthopaedics circa 2013, page 8 Doctoring a sickly system: medical errors, page 10 The two logos: university and health system, page 12 University expands neuroscience programs; Wills eye to construct sophisticated new building, page 14 Jeff hosts international medical students program, page 17 Rb2 gene therapy could shrink lung tumors, and may improve angioplasty, page 19 Gene repair could fix various inherited diseases, page 20 Alumni affairs: Events, notices, dates to remember, page 22

Department Of Radiology-Annual Executive Summary Report-July 1, 1999 To June 30, 2000, David Levin, M.D.

Department of Radiology Administrative Documents and Reports

90 page Department of Radiology Annual Executive Summary Report, July 1, 1999 to June 30, 2000, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

A Cultivated Taste For Yeast., C Brenner

Kimmel Cancer Center Faculty Papers

The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.

Jefferson Alumni Bulletin – Volume Xlix, Number 1, December 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume , Number, December 1999 Bringing Cancer Knowledge From the Laboratory to the Bedside, Page 4 Increasing the Effectiveness of Radiotherapies, Page 6 Molecular Pathways of Apoptosis are Discovered, Page 13 Structural Approaches to New Therapies: A Jefferson Symposium, Page 14 Method to Isolate Stem Cells is Found Here, Page 18 Learning Environment May Prevent Alzheimer’s, Page 21 Jefferson Ranks in the Top Quarter of All Medical Schools in Training Grants, Page 21 Book about the Art Collection is Now Available, Page 25 JAMA Study Proves That Jefferson Brings Family Physicians to Underserved Rural America, Page …

Ethnic Variability In The Treatment Of Pain, Rafael A. Ortega, Benjamin A. Youdelman, Richard C. Havel

Department of Surgery Faculty Papers

Ethnicity has been shown to be an important determinant of behavior during illness, particularly when a painful condition is present. Studies have shown that pain may be undertreated among different ethnic groups of patients. Whereas individual variations in the reaction to pain occur, available data do not support racial and/or ethnic differences in the perception of pain, leaving no justification for this discrepancy in treatment. Regardless of ethnicity, inadequate treatment of pain has been known for some time and has been referred to in recent literature as "oligoanalgesia." Lack of understanding of different ethnic and cultural groups can lead to …

The Review - Summer/Fall 1999

Jefferson Review

IN THIS ISSUE :

• Why I Hate Alumni Magazines - 2
• CHP: 30 Years and Counting - 3
• Diagnostic Imaging Set to Enter Next Millenium with a Clear Image of Its Future - 6
• Alumni Reunion Highlights - 8
• Alumni Notes - 9
• Alumni Update - 1 0
• College Notes - 1 2
• 21 st - Century Resumes: New Formats for Going after the Job Market - 1 3

Nurses Alumni Association Bulletin, Fall 1999, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1999-2000 Meeting Dates Calendar

2000 Annual Luncheon-Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

History of The Nurses Relief Fund

Nurses Wear White

Memories of My Nurse Training Days

Scholarship Funds At Work

Second Janet C. Hindson Award

Rib Ticklers

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• Nominating
• Relief Fund
• Scholarship
• Social
• Development

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Janet C. Hindson Memorial Award (How to Submit Names)

Scholarship Fund Application

Certification Reimbursement Application

Relief Fund Application …

Jefferson Alumni Bulletin – Volume Xlviii, Number 3, September 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 3, September 1999 Commencement and Reunions, Page 4 A Class Day to Remember, Page 8 Seeking a Balance among the Three Legs of the Stool, Page 9 U.S. News Ranks Jefferson One of Best in Nation, Page 14 Smullens is Named Chief Medical Officer of JHS, Page 14 Gene Repair Molecules Are Created, Page 17 Mary Monteith Honored on Her Retirement, Page 18 Bacharach Appointed Associate Dean for Alumni Relations, Page 18 Annual Giving, Page 19 Heckman, Canale in National Orthopaedics Posts, Page 53 Morrow Directs Cancer Department of ACS, Page 59 Andriole …

Phosphoinositide-Ap-2 Interactions Required For Targeting To Plasma Membrane Clathrin-Coated Pits., I Gaidarov, James H. Keen

Department of Microbiology and Immunology Faculty Papers

The clathrin-associated AP-2 adaptor protein is a major polyphosphoinositide-binding protein in mammalian cells. A high affinity binding site has previously been localized to the NH(2)-terminal region of the AP-2 alpha subunit (Gaidarov et al. 1996. J. Biol. Chem. 271:20922-20929). Here we used deletion and site- directed mutagenesis to determine that alpha residues 21-80 comprise a discrete folding and inositide-binding domain. Further, positively charged residues located within this region are involved in binding, with a lysine triad at positions 55-57 particularly critical. Mutant peptides and protein in which these residues were changed to glutamine retained wild-type structural and functional characteristics by …

Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …

Jefferson Alumni Bulletin – Volume Xlviii, Number 2, June 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 2, June 1999 Meeting Challenges from the Start, Page 4 Developing the Curriculum, Page 5 Building a Campus, Page 6 Leaders in Their Fields: The 19th Century, Page 12 In the Nation’s Service, Page 11 Keeping Pace for the 20th Century, Page 12 A Comprehensive Medical School, Page 14 How Do We Monitor the Quality of the Education? Page 17 The Jefferson Health System, Page 20 Education in the Health System, Page 22 Teaching under Managed Care, Page 24 A Student’s Perspective, Page 26 JeffHOPE: Learning and Caring Go Hand in Hand, Page …

1999 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Signal Transducer And Activator Of Transcription (Stat)5 Activation By Bcr/Abl Is Dependent On Intact Src Homology (Sh)3 And Sh2 Domains Of Bcr/Abl And Is Required For Leukemogenesis., M Nieborowska-Skorska, M A Wasik, A Slupianek, P Salomoni, T Kitamura, B Calabretta, T Skorski

Department of Microbiology and Immunology Faculty Papers

Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain. Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 3 and/or serum and did not induce leukemia in severe combined …

Radiculopathy And Myelopathy At Segments Adjacent To The Site Of A Previous Anterior Cervical Arthrodesis., Alan S. Hilibrand, Gregory D. Carlson, M A Palumbo, P K Jones, H H Bohlman

Rothman Institute Papers

BACKGROUND: We studied the incidence, prevalence, and radiographic progression of symptomatic adjacent-segment disease, which we defined as the development of new radiculopathy or myelopathy referable to a motion segment adjacent to the site of a previous anterior arthrodesis of the cervical spine.

METHODS: A consecutive series of 374 patients who had a total of 409 anterior cervical arthrodeses for the treatment of cervical spondylosis with radiculopathy or myelopathy, or both, were followed for a maximum of twenty-one years after the operation. The annual incidence of symptomatic adjacent-segment disease was defined as the percentage of patients who had been disease-free at …

Jefferson Alumni Bulletin – Volume Xlviii, Number 1, March 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 1, March 1999 Otolaryngology-Head and Neck Surgery, Page 4 Gene Therapy in a Liquid: an Easier Treatment, Page 10 Gene Repair Technique is Developed, Page 10 Moving Closer to Gene Therapy for Lung Cancer, Page 11 Frankford Hospital Joins Jefferson Health System, Page 14 Dean Gonnella Receives AAMC’s Flexner Award, Page 17

Integrin-Dependent Control Of Translation: Engagement Of Integrin Alphaiibbeta3 Regulates Synthesis Of Proteins In Activated Human Platelets., Ravinder Pabla, Andrew S. Weyrich, Dan A. Dixon, Paul F. Bray, Thomas M. Mcintyre, Stephen M. Prescott, Guy A. Zimmerman

Cardeza Foundation for Hematologic Research

Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using strategies that interrupt engagement of integrin alphaIIbbeta3 by fibrinogen and platelets deficient in this integrin, we found that alphaIIbbeta3 regulates the synthesis of B cell lymphoma 3 (Bcl-3) when platelet aggregation is induced …

Department Of Radiology-Annual Executive Summary Report-July 1, 1998 To June 30, 1999, David C. Levin, M.D.

Department of Radiology Administrative Documents and Reports

102 page Department of Radiology Annual Executive Summary Report, July 1, 1998 to June 30, 1999, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Classifying Quality Nursing Care Initiatives: Framework For Ambulatory Surgery Nursing Practice, Beth Ann Swan

College of Nursing Faculty Papers & Presentations

The demand for information about quality is greater now than ever. Despite the significance of quality to consumers, providers, and insurers of health care, information related to this phenomenon, although plentiful, has been plagued by the lack of consistent definitions, frameworks, and outcome measurements. This inconsistency leads to the inability to compare and evaluate patient outcomes from study to study and across practice settings. Assessing recovery, including symptom distress and functioning, is increasingly significant because extended operations requiring longer anesthesia are being performed in the ambulatory surgery setting. Outcomes must be linked to specific processes, and outcome information should include …

Nurses Alumni Association Bulletin, Fall 1998, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1998-1999 Meeting Date Calendar

1999 Annual Luncheon & Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

Highlight Of 1998

Operation Smile

Scholarship Funds At Work

Romania Trip

Double Honors

Doris Bowman

Memorial Service For Janet Hindson "A time for everything"

On the Lighter Side

Twenty Ways to Kill an Organization

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• By-Laws
• Relief Fund
• Social
• Scholarship
• Development
• Nominating

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Certification Reimbursement Application

Relief Fund Application

Scholarship …