Medicine and Health Sciences Commons^™

Systemic Sclerosis: Current Views Of Its Pathogenesis., Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities. Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe skin and multiple internal organ fibrosis. Mortality and morbidity in SSc are very high and are directly related to the extent of the fibrotic and microvascular alterations. A better understanding of the pathogenesis of this incurable disorder will help to better target and design effective …

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003 Dean's Column by Dean Thomas J. Nasca ’75, page 4 Update on Transplant Surgery, page 5 The New Jefferson Hospital for Neuroscience and Farber Institute for Neurosciences, page 6 Researchers Show That Human Neural Stem Cells Can Become Dopamine-Making Brain Cells in the Lab, page 8 Evidence of Greater Sensitivity to Addictive Drugs in Adolescence, page 8 New Hope for Patients with Late Stage Parkinson's, page 10 Above and Beyond the Call: Three Alumni Heroes, page 11 The Mother in The Gross Clinic: A Medical Explanation of Her Hand, page …

2003 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

European Mistletoe/Iscador® Faq , Clinic Staff

Topics in Integrative Medicine

Mistletoe (Viscum album) may be the most commonly used complementary cancer therapy in Europe today. Background information and important questions are presented.

The Review - Spring 2003

Jefferson Review

In This Issue

• 3 Message From the Dean
• 4 Special Occasions
• 5 Gail Seygal (OT ’86) - Animal Touch
• 6 War Stories
• 6 JAVA Night
• 8 Federal Stafford and Consolidation Loans
• 9 OT Students Visit Cuba
• 10 Penny Kroll, New PT Chair
• 10 New DPT
• 11 TJU Nursing Reimbursement
• 11 Lab Sciences Changes Its Name
• 12 Jeff-At-Night
• 12 Lambda Nu
• 13 Alumni Events
• 19 JCHP Awards
• 21 Student Life Award
• 22 PT Convocation
• 23 JCHP Commencement

Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students, Steven Rosenzweig Md, Diane K. Reibel, Jeffrey M. Greeson, George C. Brainard, Mohammadreza Hojat

Marcus Institute of Integrative Health Faculty Papers

Background: Medical students confront significant academic, psychosocial, and existential stressors throughout their training. Mindfulness-based stress reduction (MBSR) is an educational intervention designed to improve coping skills and reduce emotional distress.

Purpose: The purpose of this study was to examine the effectiveness of the MBSR intervention in a prospective, nonrandomized, cohort-controlled study.

Methods: Second-year students (n = 140) elected to participate in a 10-week MBSR seminar. Controls (n = 162) participated in a didactic seminar on complementary medicine. Profile of Mood States (POMS) was administered preintervention and postintervention.

Results: Baseline total mood disturbance (TMD) was greater in …

The Jeffcare Preceptor Model For Asthma: A Primary Care Physician Tutorial Training Model, Jeffrey L. Lenow, Robert Bales, Stanton N. Smullens

College of Population Health Faculty Papers

The societal and economic impact of asthma is a well-documented phenomenon in this country. Despite improved knowledge and techniques of care, there have been signs of worsening morbidity/mortality and a seeming disconnect between physician and patients as regards communication of care strategies. In an attempt to fashion innovative educational strategies to enhance primary care physician (PCP) and caregiver efficiencies in improving patient outcomes (clinical and financial), the "Preceptor" model of one-to-one PCP/asthma specialist has been developed. Review of utilization and prescribing data demonstrates a clear pattern of statistically significant cost improvement in the aggregate care setting, as well as improved …

Jefferson Alumni Bulletin – Volume 52, Number 2, March 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 2, March 2003 Dean's Column by Dean Thomas J. Nasca ’75, page 4 Ushering in the Modern Era in Surgery: the Heart-Lung Machine, Developed Here, 50 Years Ago, page 8 One of the "Seven Greatest Doctors in America", page 9 Pulmonary/Critical Care Fellows Win National Competition, Besting 88 Other Medical Schools, page 10 Two Medical Students Win AOA National Awards , page 11 Laparoscopic Radical Prostatectomy Is First in the Delaware Valley, page 12 Jefferson Surgeons Perform Philadelphia’s First Incompatible Kidney Transplant, page 12 Chinese Health Information Center Receives $1.5 Million to Expand, …

Transfection Of Il-10 Expression Vectors Into Endothelial Cultures Attenuates Alpha4beta7-Dependent Lymphocyte Adhesion Mediated By Madcam-1., Makoto Sasaki, Paul Jordan, Jeff Houghton, Xianmin Meng, Makoto Itoh, Takashi Joh, J Steven Alexander

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce inflammation and mucosal damage in models of colitis. Interleukin-10 (IL-10) is an endogenous anti-inflammatory and immunomodulatory cytokine that has been shown to prevent inflammation and injury in several animal studies, however clinical IL-10 treatment remains insufficient because of difficulties in the route of IL-10 administration and its biological half-life. Here, we examined the ability of introducing an IL-10 expression …

Evaluation Of The Penn Macy Initiative To Advance Academic Nursing Practice, Lois K. Evans Dnsc, Rn, Faan, Beth Ann Swan Phd, Crnp, Norma E. Lang Phd, Rn, Faan, Frcn

College of Nursing Faculty Papers & Presentations

In the realm of academic practice, schools of nursing, especially those in research-intensive environments, face a dilemma. These schools are in the best position to shape nursing science through research based in academic practice. Yet they also face formidable challenges to maintaining balance among the three legs of the tripartite mission. The questions of whether and how to commit resources to move forward their academic practice agendas are not answered easily. The Penn Macy Initiative to Advance Academic Nursing Practice aimed to assist such schools in their development of academic practices through a week-long intensive institute and 1 year of …

Regulation Of Human Col9a1 Gene Expression. Activation Of The Proximal Promoter Region By Sox9., Ping Zhang, Sergio A. Jimenez, David G Stokes

Department of Medicine Faculty Papers

The COL9A1 gene contains two promoter regions, one driving expression of a long alpha1(IX) chain in cartilage (upstream) and one driving expression of a shorter chain in the cornea and vitreous (downstream). To determine how the chondrocyte-specific expression of the COL9A1 gene is regulated, we have begun to characterize the upstream chondrocyte-specific promoter region of the human COL9A1 gene. Transient-transfection analyses performed in rat chondrosarcoma (RCS) cells, human chondrosarcoma (HTB) cells, and NIH/3T3 cells showed that the COL9A1 promoter was active in RCS cells but not HTB or NIH/3T3 cells. Inclusion of the first intron had no effect on promoter …

Department Of Radiology-Annual Executive Summary Report-July 1, 2002 To June 30, 2003, Vijay M. Rao, M.D.

Department of Radiology Administrative Documents and Reports

94 page Department of Radiology Annual Executive Summary Report, July 1, 2002 to June 30, 2003, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Download Full Pdf Issue-Jefferson Translations-Vol. 1, No. 1, Summer/Fall 2003

Jefferson Translations

This issue includes a description of Project CARE (Coordinated Approaches Redesigned for Excellence), an article discussing efforts to unlock the human genome, an article describing mobile asthma education efforts in Philadelphia lead by a Jefferson team of specialists, a new Jefferson anticoagulation program, and a model for diabetes education.

Signaling And Regulation Of G Protein-Coupled Receptors In Airway Smooth Muscle., Charlotte K Billington, Raymond B Penn

Department of Medicine Faculty Papers

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the …

Development And Validation Of A Professional Behavior Assessment., Kristie Koenig, Caryn Johnson, Cathleen K Morano, Joseph P Ducette

Department of Occupational Therapy Faculty Papers

Allied health students must quickly socialize into a professional role as they transition from classroom to clinic. In addition to skill development, students must exhibit a host of professional behaviors that facilitate successful interaction with patients, families, and colleagues. There is a need for a valid, reliable assessment of professional behaviors that contribute to clinical competence. This study reports on the development and validation of a professional behavior assessment for occupational therapy students on a part-time clinical rotation (Level I). The Philadelphia Region Fieldwork Consortium (PRFC) Level I Student Evaluation was developed from an initial survey (n = 75) to …

Myosin Heavy Chain And Physiological Adaptation Of The Rat Diaphragm In Elastase-Induced Emphysema., Dong Kwan Kim, Jianliang Zhu, Benjamin W Kozyak, James M Burkman, Neal A Rubinstein, Edward B Lankford, Hansell H Stedman, Taitan Nguyen, Sanford Levine, Joseph B Shrager

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expression of slower isoforms of myosin heavy chain (MHC), it has been difficult to demonstrate a shift in MHCs in an animal model that corresponds to the shift toward slower MHCs seen in human emphysema. METHODS: We sought to identify MHC and corresponding physiological changes in the diaphragms of rats with elastase-induced emphysema. Nine rats with emphysema and 11 control rats were studied 10 months after instillation with elastase. MHC isoform …

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 1, December 2002 Dean's Column by Dean Thomas J. Nasca ’75, page 4 New Chairman of Medicine Art Feldman, page 6 Rao, Buchheit, Siegman, Wender Are Appointed Chairs, page 9 Emergency Medicine Is Made a Department, page 11 Hospital Is Named as the Best in Philadelphia, page 11 Technology Transfer in the 21st Century, page 12 In Kenya, Jeff Students Reach the Underserved, page 14 African Americans' Satisfaction with Medical Careers, page 15 Ana Maria Lopez '88: Reaching Out via Telemedicine, page 22 New Consolidation Rates for Student Borrowers, page 23 Monica Morrow …

Innovation In Occupational Therapy Practice: Evidence In Working With Families Caring For Persons With Dementia, Laura N. Gitlin

Center for Applied Research on Aging and Health Research Papers

No abstract provided.

The Effectiveness Of Heart Failure Disease Management: Initial Findings From A Comprehensive Program, Janice L. Clarke, David B. Nash

College of Population Health Faculty Papers

A prevalent, chronic condition among members of the mushrooming elderly population in the United States, heart failure (HF) is a logical focus for population-based disease management. Evidence supporting the premise that multidisciplinary interventions can significantly improve clinical outcomes while decreasing the cost of medical care for people with HF is steadily mounting. A growing number of controlled and observational studies focus on the effects of HF disease management on re-admission rates, length of stay, and improvement in appropriate diagnostic testing and prescribing. This paper describes a large-scale, comprehensive HF program and reports on clinical quality, utilization, and financial outcomes observed …

Predicting High Utilization Of Emergency Department Services Among Patients With A Diagnosis Of Psychosis In A Medicaid Managed Care Organization, Tammy K. Girts, Albert G. Crawford, Neil I. Goldfarb, Mark Bachleda, Amy Grogg

College of Population Health Faculty Papers

Studies have demonstrated increased utilization of medical services for patients with behavioral health diagnoses. Medicaid managed care organizations (MMCOs) that operate under behavioral health carve-outs face the challenge of effectively targeting disease management initiatives in the absence of information on behavioral diagnoses. This study sought to develop a predictive model of emergency department (ED) utilization for patients where a diagnosis of psychosis could be identified from a claim associated with a medical service provider visit. A retrospective cohort analysis was performed using medical and pharmacy claims from an MMCO in Philadelphia, Pennsylvania, to identify patients known to have a diagnosis …

Comparisons Of American, Israeli, Italian And Mexican Physicians And Nurses On The Total And Factor Scores Of The Jefferson Scale Of Attitudes Toward Physician-Nurse Collaborative Relationships, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Sylvia K. Fields, Americo Cicchetti, Alessandra Lo Scalzo, Francesco Taroni, Anna Maria Vincenza Amicosante, Manuela Macinati, Massimo Tangucci, Carlo Liva, Gualtiero Ricciardi, Schmuel Eidelman, Hanna Admi, Hana Geva, Tanya Mashiach, Gideon Alroy, Adelina Alcorta-Gonzalez, David Ibarra, Antonio Torres-Ruiz

CRMEHC Faculty Papers

This cross-cultural study was designed to compare the attitudes of physicians and nurses toward physician–nurse collaboration in the United States, Israel, Italy and Mexico. Total participants were 2522 physicians and nurses who completed the Jefferson Scale of Attitudes Toward Physician–Nurse Collaboration (15 Likert-type items, (Hojat et al., Evaluation and the Health Professions 22 (1999a) 208; Nursing Research 50 (2001) 123). They were compared on the total scores and four factors of the Jefferson Scale (shared education and team work, caring as opposed to curing, nurses, autonomy, physicians’ dominance). Results showed inter- and intra-cultural similarities and differences among the study groups …

Nurses Alumni Association Bulletin, Fall 2002, Paula Levine, Elizabeth K. Prisnock, Marian E. Smith, Sally H. Wagner, John J. Wagner

Nursing Alumni Bulletins

2002 - 2003 Meeting Date Calendar

2003 Annual Luncheon & Meeting Notice

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

Resume of Minutes

Office News

Committee Reports

• Relief Trust Fund
• Satellite - Harrisburg Satellite Area
• Scholarship
• Social
• Nominating
• By-Laws
• Bulletin
• Development

Annual Giving Contributions

News About Graduates

Janet C. Hindson Award

Celebrating 110 Years Nursing Excellence at TJU

Memories

A Nurse 2002

A Parish - What's That

50th Anniversary Class

Class of 1952 Trolley Tour

Happy Birthday to be 80 or more

In Memoriam, Names of Deceased Graduates

Center page

Class News

Scholarship Fund Application

Certification …

The Review - Fall 2002

Jefferson Review

In This Issue

• 3 - Message From the Dean
• 4 - Drs. Erdmann and Cooter Take the Lead
• 5 - Physical Therapy Class of 1992 Together Again
• 6 - Mary G. Schaal, New Nursing Department Chair
• 7 - Diagnostic Imaging Students Discover Presentation is Important
• 8 - Special Occasions Make Special News
• 9 - JAVA Keeps Admissions Brewing
• 10 - Your Alma Mater Needs Your Support
• 10 - Changing Spaces – Campus Housing Gets a Face Lift
• 11 - Federal Stafford Loan and Interest Rates At An All Time Low
• 11 - Barbara Schock Retires
• 12 - Alumni and Almost …

The Effect Of An Interdisciplinary Community Health Project On Student Attitudes Toward Community Health, People Who Are Indigent And Homeless, And Team Leadership Skill Development, Molly A. Rose, Kevin J. Lyons, Kathleen Swenson Miller, Diane Cornman-Levy

College of Nursing Faculty Papers & Presentations

This study examined whether students’ attitudes about community health practice, attitudes toward people who are indigent and homeless, and perceived leadership skills changed after participation in a planned interdisciplinary community health experience with an urban homeless or formerly homeless population. Data were collected from medicine, nursing, occupational therapy, physical therapy, and social work students who participated in the community health experiences and from students in these disciplines who did not participate in this curriculum. The interdisciplinary community health curriculum and practicum experiences, based on the Community Health Empowerment Model (CHEM), were designed and implemented by a coalition of community and …

Patient Attitudes Toward Using Computers To Improve Health Services Delivery, Chris N. Sciamanna, Joseph A. Diaz, Puja Myne

College of Population Health Faculty Papers

BACKGROUND:The aim of this study was to examine the acceptability of point of care computerized prompts to improve health services delivery among a sample of primary care patients.

METHODS:Primary data collection. Cross-sectional survey. Patients were surveyed after their visit with a primary care provider. Data were obtained from patients of ten community-based primary care practices in the spring of 2001.

RESULTS:Almost all patients reported that they would support using a computer before each visit to prompt their doctor to: "do health screening tests" (92%), "counsel about health behaviors (like diet and exercise)" (92%) and "change treatments for health conditions" (86%). …

Physician Empathy: Definition, Components, Measurement, And Relationship To Gender And Specialty, Mohammadreza Hojat, Joseph S. Gonnella, Thomas J. Nasca, Salvatore Mangione Md, Michael Vergare, Michael Magee

CRMEHC Faculty Papers

OBJECTIVE: There is a dearth of empirical research on physician empathy despite its mediating role in patient-physician relationships and clinical outcomes. This study was designed to investigate the components of physician empathy, its measurement properties, and group differences in empathy scores.

METHOD: A revised version of the Jefferson Scale of Physician Empathy (with 20 Likert-type items) was mailed to 1,007 physicians affiliated with the Jefferson Health System in the greater Philadelphia region; 704 (70%) responded. Construct validity, reliability of the empathy scale, and the differences on mean empathy scores by physicians’ gender and specialty were examined.

RESULTS: Three meaningful factors …

Strong Partnerships Make Good Partners: Insights About Physician-Hospital Relationships From A Study Of Physician Executives, Marc A. Bard, Michael L. Buehler, Andrew L. Epstein, David B. Nash, John P. O'Connor

College of Population Health Faculty Papers

While physicians are likely to respond favorably in concept to hospital-based disease management and other clinical programs, they are less likely to accept their structural and functional characteristics. Because of their role at the hospital-physician interface, hospital physician executives are often tasked with implementing such programs. Given the challenges involved, a deeper understanding of the role of these executives in building the hospital-physician relationship will therefore be an important contribution. To this end, we surveyed senior physician executives at hospitals and health systems (n = 326), to assess their view of the hospital-physician relationship at their institutions, focusing especially on …

Jefferson Alumni Bulletin – Volume 51, Number 4, September 2002

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 51, Number 4, September 2002 Dean's Message by Dean Thomas J. Nasca ’75, page 4 Achievement Award Winner Charles Francis ’65, page 6 Jim Bagian ’77 Receives an Honorary Doctorate, page 7 Reunions and Annual Giving, page 12 Class notes attached as supplemental file.

Economic And Health Outcomes Of Capsule Endoscopy: Opportunities For Improved Management Of The Diagnostic Process For Obscure Gastrointestinal Bleeding, Neil I. Goldfarb, Amy Phillips, Mitchell Conn, Blair S. Lewis, David B. Nash

College of Population Health Faculty Papers

The estimated annual incidence of gastrointestinal bleeding in the United States is approximately 100 episodes per 100,000 persons, resulting in 300,000 hospitalizations annually. Diagnostic tools such as radiologic studies and endoscopic examination often fail to identify a source of bleeding, resulting in a cycle of repetitive testing over months or even years. Costs associated with the diagnostic process, and with interim treatment for anemia and other symptoms, can be significant. The diagnostic process also takes a toll on the patient, in terms of worry, pain, and discomfort. Capsule endoscopy, a technology that received FDA clearance in August, 2001, consists of …

High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp

Department of Medicine Faculty Papers

BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, …