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Articles 781 - 810 of 8080
Full-Text Articles in Medicine and Health Sciences
Investigation Of Cochlear Microphonics Recorded With Different Stimulus Types, Özgecan Güneşer, Ayşe Arzu Yi̇ği̇t, Asuman Alniaçik, Kürşat Yanarateş, Eda Çakmak
Investigation Of Cochlear Microphonics Recorded With Different Stimulus Types, Özgecan Güneşer, Ayşe Arzu Yi̇ği̇t, Asuman Alniaçik, Kürşat Yanarateş, Eda Çakmak
Turkish Journal of Medical Sciences
Background/aim: Electrocochleography (ECochG), one of the first defined tests under auditory evoked potentials, is a total electrical response of inner and outer hair cells inside the cochlea and auditory nerve record technique to the presence of an acoustic stimulus. T hese records can be used in Meniere disease and auditory neuropathy spectrum disorder diagnosis, intraoperative monitoring. In addition, the presence of cochlear microphonics plays a crucial role in auditory neuropathy spectrum disorder diagnosis. In our study, healthy individuals were tested with extratimpanic electrocochleography record method via Click and LS CE-Chirp stimulus, and the results were compared to the age, sex, …
Nucleolus Assessment In Invasive Breast Carcinoma, An Objective Parameter For Histological Grading, Seda Duman Öztürk, Çi̇ğdem Öztürk, Oğuzhan Okcu, Bayram Şen, Recep Bedi̇r
Nucleolus Assessment In Invasive Breast Carcinoma, An Objective Parameter For Histological Grading, Seda Duman Öztürk, Çi̇ğdem Öztürk, Oğuzhan Okcu, Bayram Şen, Recep Bedi̇r
Turkish Journal of Medical Sciences
Background/aim: The nucleolus has the potential to provide insight into how many types of cancer will progress. In this study, we examined the evaluation of the nucleolus with a microscope in widespread breast cancer tumors and whether this value contributes to tumor grading as an objective clinicopathological parameter. Materials and methods: In our study, the nucleolus was evaluated retrospectively in resections with a diagnosis of invasive breast carcinoma of the cases between January 2010 and April 2021. In total, the tumor nucleolus of 377 cases of invasive breast carcinoma was evaluated. Nucleolus evaluation was performed with light microscopy using four …
Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir
Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Background/aim: Ultrasonography and fine-needle aspiration biopsy are frequently used to diagnose thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. This study investigated whether there is a relationship between thiol/ disulphide homeostasis and cytological and histopathological diagnosis of thyroid nodules. Materials and methods: The patient group consisted of 81 individuals with euthyroid nodular (single/multiple) goiter scheduled for thyroidectomy, and the control group consisted of 28 age- and sex-matched healthy volunteers who had no thyroid nodule on ultrasonographic evaluation. All participants were selected among the admissions to the study clinic between June 2017 and June 2018, and …
Pd-L1 And Ebv Lmp1 Expressions In Classic Hodgkin Lymphomas And Its Correlation With Clinicopathological Parameters And Prognosis, Süleyman Özdemi̇r, Özlem Ton, Fevzi̇ye Kabukcuoğlu
Pd-L1 And Ebv Lmp1 Expressions In Classic Hodgkin Lymphomas And Its Correlation With Clinicopathological Parameters And Prognosis, Süleyman Özdemi̇r, Özlem Ton, Fevzi̇ye Kabukcuoğlu
Turkish Journal of Medical Sciences
Background/aim: Programmed death pathway leads to T cell anergy. Wide range of malignancies take advantage of this pathway by programmed death-ligand 1 (PD-L1) expression either on neoplastic cells or on the nonneoplastic cells of tumour microenvironment. New therapeutic approaches have been directed against this pathway. We studied PD-L1 expression on both neoplastic Hodgkin and Reed-Sternberg (HRS) cells and cells of tumour microenvironment in classic Hodgkin lymphoma (CHL) patients and compared it with Ebstein-Barr virus (EBV) positivity, clinical data, and survival rates. Materials and methods: Lymph node excision materials of 56 CHL patients diagnosed between 2007 and 2017 were included in …
Evaluation Of Cardiovascular Changes In Patients With Gastric Wall Fat Halo Sign, Ali̇ Küpeli̇, Eser Bulut, Edhem Ünver, Gürkan Danişan
Evaluation Of Cardiovascular Changes In Patients With Gastric Wall Fat Halo Sign, Ali̇ Küpeli̇, Eser Bulut, Edhem Ünver, Gürkan Danişan
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate the relationship between gastric wall fat halo sign and potentially associated cardiovascular disease (CVD) in thoracic computed tomography (CT). Materials and methods: Between October 2020 and January 2021, 62 patients with gastric wall fat halo sign and 62 controls were evaluated with thorax CT. Patient's height, weight, body mass index (BMI), sex, age, comorbidities, laboratory parameters, diameters of cardiac axes, aorta and pulmonary artery; aorta and coronary artery calcium scores were recorded for the two groups. Results: No significant differences were found in sex, age, height, body weight or BMI between the two groups …
Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu
Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma. The aim of this study is to present the results of the patients we treated with the diagnosis of EMC as an oncology reference center. Materials and methods: Information on 13 patients diagnosed with EMC between 2006 and 2018 was retrospectively reviewed. Patients' demographic information, tumor sizes, surgical treatments, chemotherapy and radiotherapy statuses, follow-up times, recurrences, and metastases were recorded. Results: Mean patient age was 53.6 ± 15 years (range: 28-73). In 8 patients, the tumor was located in the lower limbs, most commonly in the thigh (46.2%). Mean …
The Reliability And Validity Of The Turkish Version Of The Multiple Sclerosis Impact Scale-29, Fati̇h Özden, Mehmet Özkeski̇n, Ayşe Nur Yüceyar
The Reliability And Validity Of The Turkish Version Of The Multiple Sclerosis Impact Scale-29, Fati̇h Özden, Mehmet Özkeski̇n, Ayşe Nur Yüceyar
Turkish Journal of Medical Sciences
Background/aim: The purpose of the study was to cross-culturally adapt the Multiple Sclerosis Impact Scale-29 (MSIS-29) into Turkish and evaluate its reliability and validity in patients with Multiple Sclerosis (MS). Materials and methods: A total of 119 individuals with MS were enrolled in the research. The neurologist classified the patients with Expanded Disability Status Scale (EDSS). In the initial evaluation, patients completed the Multiple Sclerosis Impact Scale-29 (MSIS29), the Multiple Sclerosis International Quality of Life (MusiQoL), EuroQol-5D-3L (EQ-5D-3L), and Beck Depression Scale (BDS), respectively one week later, the MSIS-29 evaluation was repeated. Internal consistency, test-retest reliability, and construct validity were …
The Correlation Of Serum Spd-1 And Spd-L1 Levels With Clinical, Pathological Characteristics And Lymph Node Metastasis In Nonsmall Cell Lung Cancer Patients, Burcu Ancin, Mesut Meli̇h Özercan, Yi̇ği̇t Yilmaz, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan, Meti̇n Demi̇rci̇n
The Correlation Of Serum Spd-1 And Spd-L1 Levels With Clinical, Pathological Characteristics And Lymph Node Metastasis In Nonsmall Cell Lung Cancer Patients, Burcu Ancin, Mesut Meli̇h Özercan, Yi̇ği̇t Yilmaz, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan, Meti̇n Demi̇rci̇n
Turkish Journal of Medical Sciences
Background/aim: Significant advances have been achieved in immunotherapy for the treatment of lung cancer. It is known that tumor cells and cells in the tumor microenvironment express high amounts of programmed cell death ligand 1 (PD-L1). These PD-L1s interact with programmed cell death protein 1 (PD-1), causing immunosuppression. The aim of our study is to examine the correlation between the serum sPD-1 and sPD-L1 levels and clinicopathological characteristics in patients with nonsmall cell lung cancer. We also compared our results with the healthy population (control group). Materials and methods: Thirthy-seven nonsmall cell lung cancer (NSCLC) patients who were operated in …
Could Lysosomal Acid Lipase Enzyme Activity Be Used For Clinical Follow-Up In Cryptogenic Cirrhosis?, Engi̇n Köse, Elçi̇n Çağatay, Tutku Yaraş Mercan, Peli̇n Teke Kisa, Semi̇nay Güler, Zümrüt Arslan Gülten, Mesut Akarsu, Yavuz Oktay, Hülya Ayar Kayali, Nur Arslan
Could Lysosomal Acid Lipase Enzyme Activity Be Used For Clinical Follow-Up In Cryptogenic Cirrhosis?, Engi̇n Köse, Elçi̇n Çağatay, Tutku Yaraş Mercan, Peli̇n Teke Kisa, Semi̇nay Güler, Zümrüt Arslan Gülten, Mesut Akarsu, Yavuz Oktay, Hülya Ayar Kayali, Nur Arslan
Turkish Journal of Medical Sciences
Background/aim: Cholesterol ester storage disease (CESD) is one of the rare causes that should be kept in mind in the etiology of cirrhosis. Recent studies detected that significantly reduced lysosomal acid lipase deficiency enzyme (LAL) in patients with cryptogenic cirrhosis (CC). Moreover, studies have evaluated that LAL activity is as effective as scoring systems in assessing the severity of cirrhosis. In this study, we aimed to investigate the CESD with LAL level and mutation analysis of LIPA gene in patients diagnosed with CC and to compare LAL activities between patients with CC and healthy volunteers. Materials and methods: Laboratory parameters …
Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz
Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz
Turkish Journal of Medical Sciences
Background/aim: Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods: Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results: The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 …
Cha2ds2-Vasc Score As A Prognostic Indicator In Patients With Atrial Fibrillation Undergoing Coronary Stenting, Jian-Yong Zheng, Dong-Tao Li, Yi-Gang Qiu, Yi-Xiong Huang, Zheng-Ming Xu, Li Zhao, Yu Chen, Yi Cao, Yi-Da Tang, Cheng-Jun Guo, Zhi-Min Ma, Yong-Quan Wu, Yan Jiao, Tian-Chang Li
Cha2ds2-Vasc Score As A Prognostic Indicator In Patients With Atrial Fibrillation Undergoing Coronary Stenting, Jian-Yong Zheng, Dong-Tao Li, Yi-Gang Qiu, Yi-Xiong Huang, Zheng-Ming Xu, Li Zhao, Yu Chen, Yi Cao, Yi-Da Tang, Cheng-Jun Guo, Zhi-Min Ma, Yong-Quan Wu, Yan Jiao, Tian-Chang Li
Turkish Journal of Medical Sciences
Background/aim: Patients with atrial fibrillation (AF) and coronary stenting had a poor prognosis. This study aimed to assess the accuracy of CHA2 DS2 -VASc score for predicting and grading adverse clinical outcomes in this population. Materials and methods: We reviewed the clinical data of all patients with previously documented nonvalvular AF who underwent coronary stenting between January 2010 and June 2015 in 12 hospitals of Beijing, China. The study population was divided into three groups: 1) Low CHA2 DS2 -VASc score, ≦ 2 points, 2) Intermediate score, 3-4 points, and 3) High score, ≧ 5 points. Major adverse cardiac/cerebrovascular events …
Are Disease-Related Symptoms Important To Predicting Developing Diabetes From Prediabetes?, Si̇bel Engi̇n, Tolga Akkan, Murat Dağdevi̇ren, Ti̇jen Şengezer, Mustafa Altay
Are Disease-Related Symptoms Important To Predicting Developing Diabetes From Prediabetes?, Si̇bel Engi̇n, Tolga Akkan, Murat Dağdevi̇ren, Ti̇jen Şengezer, Mustafa Altay
Turkish Journal of Medical Sciences
Background/aim: There are not many studies conducted to detect and recognize the symptoms during the prediabetes period. In our study, we aimed to determine the symptoms that can be seen in prediabetes and diabetes and their prevalence and to determine the similarities and differences between the two groups. Materials and methods: Individuals who were diagnosed with prediabetes or diabetes, over the age of 18, literate, and accepted to collaborate were included in our study. The "Diabetes Symptoms Checklist Scale" was used by interviewing 321 participants, 161 prediabetic and 160 diabetic, face-to-face. Results: It has been found that the most common …
The Clinical And Demographical Characteristics Of Turkish Pediatric Lymphedema Patients: A Multicenter Study, Pinar Borman, Ayşegül Balcan, Si̇bel Eyi̇gör, Evri̇m Coşkun, Fi̇kri̇ye Fi̇gen Ayhan, Burcu Duyur Çakit, Seçi̇l Vural, Meltem Vural, Esra Deni̇z Papatya Çakir, Deni̇z Nazi̇re Çağdaş Ayvaz, Ayşegül Yaman, Ayşe Beyhan Lale Cerrahoğlu, Sevi̇l Ceyhan Doğan
The Clinical And Demographical Characteristics Of Turkish Pediatric Lymphedema Patients: A Multicenter Study, Pinar Borman, Ayşegül Balcan, Si̇bel Eyi̇gör, Evri̇m Coşkun, Fi̇kri̇ye Fi̇gen Ayhan, Burcu Duyur Çakit, Seçi̇l Vural, Meltem Vural, Esra Deni̇z Papatya Çakir, Deni̇z Nazi̇re Çağdaş Ayvaz, Ayşegül Yaman, Ayşe Beyhan Lale Cerrahoğlu, Sevi̇l Ceyhan Doğan
Turkish Journal of Medical Sciences
Background/aim: Reducing lymphedema-associated burden and disability in the pediatric setting requires improved awareness and understanding clinical properties of the lymphedema. The aim of this study was to evaluate the clinical and demographic characteristics of patients with pediatric lymphedema presented to different lymphedema centers in Turkey. Materials and methods: The socio-demographic and clinical characteristics of the children including age, gender, presence of genetic syndromes, duration of edema, site and stage of lymphedema and the received therapies were determined. Parental and children education on self-management techniques were recorded. Results: A total of 122 children (female: 66, male: 56) with a mean age …
Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel
Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel
Turkish Journal of Medical Sciences
Background/aim: Clinically isolated syndrome (CIS) may be the first presentation of pediatric onset multiple sclerosis (POMS). We retrospectively evaluated the clinical and laboratory data of pediatric CIS (pCIS) patients who were diagnosed with POMS upon followup for any predictive variables. We also reviewed the literature concerning the management of pCIS. Materials and methods: This single-center study involved patients who had pCIS in childhood that converted to POMS during followup between 2011 and 2021. Sixteen patients were included in the study. The data were evaluated retrospectively and analyzed with descriptive statistics. Results: The majority of the pCIS patients were female (F/M: …
Stable And Exacerbation Period Serum Cytokine And Periostin Levels Of The Five Distinct Phenotypes Of Severe Asthma, Murat Türk, İnsu Yilmaz, Selma Gökahmetoğlu, Ayşe Nedret Koç
Stable And Exacerbation Period Serum Cytokine And Periostin Levels Of The Five Distinct Phenotypes Of Severe Asthma, Murat Türk, İnsu Yilmaz, Selma Gökahmetoğlu, Ayşe Nedret Koç
Turkish Journal of Medical Sciences
Background/aim: The differences in molecular mechanisms during a stable period and the changes in the inflammatory responses during exacerbations between distinct severe asthma phenotypes remain unclear. In this study, we aimed to characterize stable and exacerbation period serum cytokine and periostin levels of 5 different predefined severe asthma phenotypes with real-life data. Changes in the viral infection-induced exacerbations were also analyzed. Materials and methods: Serum levels of 8 cytokines and periostin were measured from the sera obtained from the adult patients with five different severe asthma phenotypes based on the presence/absence of aeroallergen sensitivity, peripheral eosinophilia and chronic rhinosinusitis with …
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Turkish Journal of Medical Sciences
Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …
Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li
Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to investigate the success rate of volar plate treatment of distal radius fractures with preservation of the pronator anterior muscle; the incidence of complications, such as infection, vascular nerve injury, and tendon injury; fracture healing rate; and changes in muscle anatomy. Materials and methods: The Henry approach was adopted to treat distal radius fractures with pronator quadratus (PQ) preservation on a trial basis. Between June 2015 and January 2017, 46 cases of distal radius fractures were considered according to the Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification. The PQ was preserved, the distal margin was …
A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik
A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik
Turkish Journal of Medical Sciences
Background/aim: Sacrococcygeal teratomas (SCT) are known as rare tumors, but they are the most common tumor in fetuses and newborns. This study aims to present fetal magnetic resonance imaging (MRI) findings of SCT diagnosed prenatally and compare them with that of the prenatal Ultrasound (US) findings. Materials and methods: Eleven patients diagnosed as SCT prenatally by US and further assessed by MRI are included. MRI was performed via a 1.5-T magnet with a body coil. The presence, size, content extension, and compressive effects of each mass were determined and correlated with US findings and with postnatal examinations, including surgery and …
Effect Of Cell Salvage On Bleeding, Transfusion Of Blood Products, And Bleeding Parameters In Patients Undergoing Liver Transplantation With Intraoperative Massive Blood Transfusion, Tümay Uludağ Yanaral, Peli̇n Karaaslan
Effect Of Cell Salvage On Bleeding, Transfusion Of Blood Products, And Bleeding Parameters In Patients Undergoing Liver Transplantation With Intraoperative Massive Blood Transfusion, Tümay Uludağ Yanaral, Peli̇n Karaaslan
Turkish Journal of Medical Sciences
Background/aim: Autologous transfusion using a cell saver system has been used in liver transplantation with controversial outcomes. Its efficiency in patients with massive intraoperative transfusion has not been studied yet. This study aimed to evaluate effect of cell salvage (CS) on intraoperative bleeding and transfusion practices in liver transplantation with massive intraoperative transfusion. Materials and methods: Consecutive patients aged ≥18 years with intraoperative massive blood transfusion (≥ 6 units) between March 2014 and September 2020 were included. Patients subjected to CS were grouped as CS, whereas other patients were grouped as control. Number of transfused red blood cells was study's …
Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu
Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Venom immunotherapy (VIT) is the most effective treatment method to prevent recurrent systemic reactions to Hymenoptera stings. In this study, the demographic characteristics of VIT patients, the success rates of VIT, the difficulties we encountered during VIT, and solutions for these difficulties in our clinic were presented. Materials and methods: We retrospectively analyzed patients with venom allergy who applied venom immunotherapy between 2013- 2020. Data on age, gender, Hymenoptera species with the first reaction, grade of the reaction, beekeeping history, skin prick and specific IgE and component results, double sensitization, blood groups, and reactions with VIT and/or sting during …
Comparison Of Two Different Minimally Invasive Techniques Used In Bladder Stone Surgery For Preschool-Aged Children, İsmai̇l Yağmur, Mehmet Demi̇r, Bülent Kati, Eyyup Sabri̇ Peli̇t, Eser Ördek, Hali̇l Çi̇ftçi̇
Comparison Of Two Different Minimally Invasive Techniques Used In Bladder Stone Surgery For Preschool-Aged Children, İsmai̇l Yağmur, Mehmet Demi̇r, Bülent Kati, Eyyup Sabri̇ Peli̇t, Eser Ördek, Hali̇l Çi̇ftçi̇
Turkish Journal of Medical Sciences
Background/aim: This study was designed to compare the outcomes of mini-percutaneous cystolithotomy (mPCL) and transurethral cystolithotripsy (TUCL) in treating bladder stones in preschool-aged children (≤6 years old). Materials and methods: Twenty-four patients treated with mPCL and 28 patients treated with TUCL for bladder stones were compared retrospectively. The operative and postoperative outcomes of both groups were analyzed. Results: The mean age and gender distribution were similar between the groups. The mean stone size was 16.5 ± 0.5 mm for the mPCL group and 14.9 ± 5.7 mm for the TUCL group (p = 0.318). The mean operative time was 41.1 …
Examination Of Diaphragm Thickness, Mobility And Thickening Fraction In Individuals With Copd Of Different Severity, Ceyhun Topcuoğlu, Eylem Tütün Yümi̇n, Mustafa Hizal, Suat Konuk
Examination Of Diaphragm Thickness, Mobility And Thickening Fraction In Individuals With Copd Of Different Severity, Ceyhun Topcuoğlu, Eylem Tütün Yümi̇n, Mustafa Hizal, Suat Konuk
Turkish Journal of Medical Sciences
Background/aim: Diaphragm thickness and mobility assessed by ultrasound in individuals with Chronic Obstructive Pulmonary Disease (COPD) reflect the function of the diaphragm. The aim of this study is to compare the diaphragm thickness, mobility, and thickening fraction in individuals with COPD of different severity and healthy individuals and examine the relationship between these parameters and pulmonary function test parameters. Materials and methods: A cross-sectional observational study design was used. Thirty individuals (mild = 11; moderate = 13; severe = 6) with COPD and 29 healthy male individuals aged between 40-75 years were included in the study. The individuals included in …
A Combination Of Q-Tof Lc/Ms And Lc-Ms/Ms Based Metabolomics In Pediatric-Onset Multiple Sclerosis Demonstrates Potential Biomarkers For Unclassified Patients, İsmai̇l Solmaz, Ozan Kaplan, Mustafa Çelebi̇er, İnci̇lay Lay, Fatma Banu Anlar
A Combination Of Q-Tof Lc/Ms And Lc-Ms/Ms Based Metabolomics In Pediatric-Onset Multiple Sclerosis Demonstrates Potential Biomarkers For Unclassified Patients, İsmai̇l Solmaz, Ozan Kaplan, Mustafa Çelebi̇er, İnci̇lay Lay, Fatma Banu Anlar
Turkish Journal of Medical Sciences
Background/aim: Metabolomics has the potential to provide putative biomarkers and insights into the pathophysiology and diagnosis of pediatric multiple sclerosis (pMS), which is an inflammatory demyelinating disorder of the central nervous system with a broad spectrum of clinical manifestations. In this study, we aimed to investigate serum metabolomics in pMS to help elucidate the pathophysiology of MS. Materials and methods: An untargeted approach was applied using the quadrupole time-of-flight liquid chromatography/mass spectrometry (Q-TOF LC/MS) method to study plasma metabolites in patients with pMS (n = 33), patients with unclassified central nervous system demyelinating diseases (n = 6), and age-matched healthy …
Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay
Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay
Turkish Journal of Medical Sciences
Background/aim: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. Materials and methods: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. Results: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and …
Is Microwave Ablation Therapy As Effective As Colorectal Liver Metastases In Noncolorectal Liver Metastases?, Gürkan Danişan, Ali̇ Küpeli̇, Ogün Taydaş
Is Microwave Ablation Therapy As Effective As Colorectal Liver Metastases In Noncolorectal Liver Metastases?, Gürkan Danişan, Ali̇ Küpeli̇, Ogün Taydaş
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the relationship between primary tumor type and the effectiveness of microwave ablation (MWA) therapy by comparing the technical and clinical outcomes of MWA in the treatment of colorectal liver metastases (CLM) and noncolorectal liver metastases (NCLM). Materials and methods: Between January 2019 and March 2021, 47 consecutive patients (25 male, 22 female) with a total of 63 unresectable hepatic metastases underwent MWA under ultrasound guidance. The patients were divided into CLM (n = 29) and NCLM (n = 18) groups. Patient demographics, procedural details, and complications were noted. The overall survival …
Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu
Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu
Turkish Journal of Medical Sciences
Background/aim: The use of Transcranial Magnetic Stimulation (TMS) in the add-on treatment of patients with treatment-resistant depression (TRD) is becoming more common. This study aims to investigate the efficacy of TMS on depression and accompanying anxiety symptoms among patients with TRD. Materials and methods: The current study was conducted with 38 patients diagnosed with TRD. The patients were randomly divided into two groups and received 20 sessions of high-frequency (10Hz) TMS and 20 sessions of sham TMS to the left dorsolateral prefrontal cortex in a double-blind and cross-over fashion without a change in their pharmacotherapy. In the clinical evaluation, Hamilton …
Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu
Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu
Turkish Journal of Medical Sciences
Background/aim: Alpha-lipoic acid (ALA) is a natural compound, one of the natural antioxidants with high activity. In the NADPH oxidase family, NADPH oxidase 4 (NOX4) is an important subunit participating in the production of ROS. NADPH oxidase 2 (NOX2) can form active NADPH oxidase complexes when binding to several other subunits in the cytoplasm, and NOX2 is its major functional subunit. Rapid atrial pacing (RAP) model was constructed to study the effects of ALA on electrical and structural remodeling in rabbits. Materials and methods: Thirty rabbits were divided into SHAM group, RAP group and ALA+RAP group. Their right atriums were …
Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural
Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate the use of tissues with multiple traumas, scarred pedicles, and medial scarring as a flap. Materials and methods: Forty-eight rats were randomly divided into four equal groups. The modified McFarlane flap was chosen as the flap model. In Group 1 (control), a dorsal skin flap was elevated and then sutured back into original position. In the other groups, a two-phase procedure was used. In Group 2 (pedicle incision), scar tissue was created with a skin incision at the prospective pedicle site of the flap and then sutured to its original site. …
Future Pandemics: How Can We Be Ready?, Zeynep Türe Yüce, Emi̇ne Alp Meşe
Future Pandemics: How Can We Be Ready?, Zeynep Türe Yüce, Emi̇ne Alp Meşe
Turkish Journal of Medical Sciences
No abstract provided.
Low-Dose Valacyclovir Use With Preemptive Monitoring In Kidney Transplant Recipients With Intermediate Cytomegalovirus Infection Risk, Arzu Veli̇oğlu, Selma Alagöz, Di̇lek Barutçu Ataş, İzzet Hakki Arikan, Ebru Aşicioğlu, Mehmet Burak Aksu, Nurhan Seyahi̇, Zübeyde Serhan Tuğlular
Low-Dose Valacyclovir Use With Preemptive Monitoring In Kidney Transplant Recipients With Intermediate Cytomegalovirus Infection Risk, Arzu Veli̇oğlu, Selma Alagöz, Di̇lek Barutçu Ataş, İzzet Hakki Arikan, Ebru Aşicioğlu, Mehmet Burak Aksu, Nurhan Seyahi̇, Zübeyde Serhan Tuğlular
Turkish Journal of Medical Sciences
No abstract provided.