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Articles 7561 - 7590 of 8080
Full-Text Articles in Medicine and Health Sciences
Clinical And Histopathological Indicators Of Neckmetastasis In Laryngeal Carcinoma, Şefi̇k Hali̇t Akmansu, Hakan Korkmaz, Engi̇n Dursun, Seli̇m Sermet Erbek, Hakan Göçmen, Tuğba Ünal, Cavi̇t Özeri̇
Clinical And Histopathological Indicators Of Neckmetastasis In Laryngeal Carcinoma, Şefi̇k Hali̇t Akmansu, Hakan Korkmaz, Engi̇n Dursun, Seli̇m Sermet Erbek, Hakan Göçmen, Tuğba Ünal, Cavi̇t Özeri̇
Turkish Journal of Medical Sciences
Determination of cervical metastasis preoperatively is very important in planning the treatment strategy in laryngeal carcinoma. In spite of vigorous clinical and detailed high technology radiological examinations, the occult metastasis rate is between 12-17% in No necks. In recent years most of the studies are related to the clinical and histopathological risk factors that may effect cervical metastasis. In this study we reviewed the primary tumors and neck specimens of laryngeal carcinoma patients operated in our clinic retrospectively. In 46 laryngeal carcinoma patients with laryngectomy and neck dissection, the following criteria were examined; Tumor localization, T status, histologic grading, peripheral …
Comparison Of Intubation Conditions Ofalfentanil And Propofol With Atracurium In Shortprocedures Of Children, Ahmet Can Şenel, Erdem Nai̇l Duman, Mevlüt Yurtseven, Gönül Aktürk
Comparison Of Intubation Conditions Ofalfentanil And Propofol With Atracurium In Shortprocedures Of Children, Ahmet Can Şenel, Erdem Nai̇l Duman, Mevlüt Yurtseven, Gönül Aktürk
Turkish Journal of Medical Sciences
We have assessed tracheal intubating conditions in 45 ASA I-II children, aged 4-14 years undergoing elective ear, nose and throat surgery. After the induction dose of propofol 2.5 mgkg -1 , group I received alfentanil 10 µgkg -1 , group II received alfentanil 20 µgkg -1 and group III received atracurium 0.5 mgkg-1 for tracheal intubation. The mean arterial pressure (MAP), heart rate (HR), arterial oxygen saturation (SaO 2 ), end tidal carbondioxide (ETCO2) and intubation conditions were investigated. The quality of tracheal intubation was graded according to the ease of laryngoscopy, position of the vocal cords, coughing and jaw …
Autosomal Dominant Osteopetrosis Type Ii, Kazim Şenel, Si̇nan Sönmez, Lale Cerrahoğlu, Mahi̇r Uğur, Selami̇ Suma
Autosomal Dominant Osteopetrosis Type Ii, Kazim Şenel, Si̇nan Sönmez, Lale Cerrahoğlu, Mahi̇r Uğur, Selami̇ Suma
Turkish Journal of Medical Sciences
No abstract provided.
Ultrasound And Magnetic Resonance Imagingfindings Of Choroid Plexus Papilloma, Suat Eren, Pinar Polat, Yusuf Tüzün, Selami̇ Suma
Ultrasound And Magnetic Resonance Imagingfindings Of Choroid Plexus Papilloma, Suat Eren, Pinar Polat, Yusuf Tüzün, Selami̇ Suma
Turkish Journal of Medical Sciences
No abstract provided.
Neonatal Cerebral Candida Abscess: Radiologic And Clinical Findings, Ömer Cevi̇t, Hulusi̇ Eği̇lmez, Hayri̇ B. Toksoy, Di̇lara İçağasioğlu, Turan Sarikaya, İdri̇s Sütçü
Neonatal Cerebral Candida Abscess: Radiologic And Clinical Findings, Ömer Cevi̇t, Hulusi̇ Eği̇lmez, Hayri̇ B. Toksoy, Di̇lara İçağasioğlu, Turan Sarikaya, İdri̇s Sütçü
Turkish Journal of Medical Sciences
No abstract provided.
The Use Of Polypeptide Probes Selected Fromartificial Peptide Libraries For The Recognitionand Differentiation Of Dna Sequences, Erol Ömer Atalay, Berri̇n Erdağ, Beyazit Çirakoğlu
The Use Of Polypeptide Probes Selected Fromartificial Peptide Libraries For The Recognitionand Differentiation Of Dna Sequences, Erol Ömer Atalay, Berri̇n Erdağ, Beyazit Çirakoğlu
Turkish Journal of Medical Sciences
In the novel approach suggested here, we examined the use of polypeptide probes selected from artificial peptide libraries for the identification of the differences in dsDNA sequences which are potential targets for the genetic diseases. As a model system two target DNAs which are the polymerase chain reaction (PCR) products of the two hage-display vector multiple cloning sites (MCS) differing at 18 base pair long has been used. In the production of the target sequences biotinylated primers were used in PCR. The polypeptide probes obtained from artificial peptide library by the selection of phage-display techniques. Identified clones bearing the candidate …
Technical Approach To Generate Polyclonalantibodies Against Bacterially Expressed Gst-Pyk-C: Evaluation Of Cross-Reaction Andrecognition In Some Mammalian And Yeast Celllysates, Ayşegül Ayyildiz
Turkish Journal of Medical Sciences
Pyk-2 is a protein tyrosine kinase, highly expressed in human hippocampus, dentate gyrus and olfactory bulb. In this study, polyclonal antibodies against the C-terminal of pyk-2, starting from Pro-759, were generated by injecting rabbits with the bacterially expressed GST fusion construct, generated by cloning the C-terminal domain of pyk-2 into pGEX-3X vector and affinity purification to increase the specificity of recognition. Anti-pyk-C was shown to recognize a 123 kD band in Western Blots of 293 cells transfected with pyk-2, as well as PC-12, COS and 3T3 cells and not to cross-react with FAK transfected Sf-21 lysates, in spite of high …
Opioid Modulation Of The Pre-Ovulatory Lh Surge In The Conscious Rat: Involvement Of Indolamines, Bayram Yilmaz, Desmond P. Gilmore
Opioid Modulation Of The Pre-Ovulatory Lh Surge In The Conscious Rat: Involvement Of Indolamines, Bayram Yilmaz, Desmond P. Gilmore
Turkish Journal of Medical Sciences
Endogeonus opioid peptides play an important role in the generation of the pre-ovulatory LH surge. We investigated the interrelationship between the oploid and indolaminergic systems in the regutalion of LH secretion, and the involvement of \mu-and \kappa-opioid subtypes in this process. Concsious female rats bearing cannula in the femoral artery were injected intraperitoneally with \mu-(diamorphine) and \kappa -(U-50488H) opioid agonists either alone or with their respective antagonists, naloxone and MR2266, on pro-oestrus. Blood samples were collected hourly between 15.00 and 19.00 and plasma LH levels were measured by RIA. 5-HT and 5-HIAA concentrations were determined by HPLC-ECD in the MPOA, …
Effects Of Cyclosporin A On Rat Pancreatic \Beta And Dcells And Glucose Levels (An Immunocytochemicalstudy), Kadri̇ Güven, Fi̇gen Öztürk, Fahretti̇n Keleşti̇mur
Effects Of Cyclosporin A On Rat Pancreatic \Beta And Dcells And Glucose Levels (An Immunocytochemicalstudy), Kadri̇ Güven, Fi̇gen Öztürk, Fahretti̇n Keleşti̇mur
Turkish Journal of Medical Sciences
The effects of cyclosporin A (CsA) on rat pancreatic islet \beta and D cells and plasma glucose levels at doses of 50 mg/kg body weight applied for 20 days were investigated. Fifteen Swiss Albino rats were used as the study group and 5 were the control group. Rat pancreatic islet \beta and D cells were stained immunocytochemically by anti-insulin and anti-somatostation antibodies. \beta and D cells from 15 different islets were evaluated qualitatively and quantitatively. Plasma glucose changes were also compared between the study and the control group. The pancreas morphology was found to be normal in both groups by …
The Effects Of Hyaluronic Acid On Myringoplasty Inrats, Ahmet Kutluhan, Serdar Uğraş, Emi̇n İnalkaç, Nusret Akpolat
The Effects Of Hyaluronic Acid On Myringoplasty Inrats, Ahmet Kutluhan, Serdar Uğraş, Emi̇n İnalkaç, Nusret Akpolat
Turkish Journal of Medical Sciences
Tympanic membrane perforations arise from a variety of causes. Some of them require myringoplasty. In this study, we used hyaluronic acid, a polysaccharide with high-molecular- weight which may be obtained commercially and affects modulations of cell function. An experimental myringoplasty was performed on rats in which a chronic dry tympanic membrane perforation was formed. While physiological saline was embedded in Gelfoam ® which was supported under and over the graft, in group 1, hyaluronic acid embedded gelfoam was used in group 2. Better epithelization, less calcification and scar tissue were established in group 2 myringoplasties. This study shows that hyaluronic …
The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer
The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer
Turkish Journal of Medical Sciences
The effect of primaquine on the enzymatic antioxidant defence mechanisms of erythrocytes were determined by measuring the activities of the below enzymes, before and after 30 minutes of incubation of hemolyzates with 1 mM primaquine at 37°C. Among the enzymes studied glucose-6- phosphate dehydrogenase seemed the most sensitive enzyme; 57 % and 78 % inhibition at zero (due to the binding of primaquine to NADP binding site) and 30 minutes of incubation (due to the reactive oxygen species), respectively. Catalase, superoxide dismutase, and glutathione-S-transferase were less sensitive to primaquine-derived reactive oxygen species: 33, 11, and 0 % inhibition at the …
Estimation Of The Prevalence Of A Disease From Screening Tests, Ergun Karaağaoğlu
Estimation Of The Prevalence Of A Disease From Screening Tests, Ergun Karaağaoğlu
Turkish Journal of Medical Sciences
Since most secreening tests are not 100% accurate, the proportion of subjects screened positive in such a test cannot be used as an estimate of the population prevalence. Methods which take sensitivity and the specificity into consideration should be employed in such circumstances. Estimation of the population prevalence as defined by Gartand Buck may produce results which are outside the range of 0 to 1. A Bayesian approach avoids results of this kind, but requires complicated computations. Lew and Levy proposed an approximation to the Bayesian estimate of the population prevalence. To simplify the computations, I propose a method which …
Spinal Anesthesia In Children With Rectalpremedication With Midazolam, Ketamine Andatropine, Bi̇nnur Sarihasan, Si̇bel Bariş, Fadi̇me Yeşi̇ltaş, Ayla Tür, Haydar Şahi̇noğlu, Emre Üstün, Fuat Güldoğuş, Deni̇z Karakaya, Zeynep Kayhan
Spinal Anesthesia In Children With Rectalpremedication With Midazolam, Ketamine Andatropine, Bi̇nnur Sarihasan, Si̇bel Bariş, Fadi̇me Yeşi̇ltaş, Ayla Tür, Haydar Şahi̇noğlu, Emre Üstün, Fuat Güldoğuş, Deni̇z Karakaya, Zeynep Kayhan
Turkish Journal of Medical Sciences
This study was designed to investigate the anxiolytic effects as well as acceptance of spinal anesthesia after rectally administered midazolam, ketamine and atropine for postoperative sedation in children. Spinal anesthesia is an easy and safe method in the pediatric age group especially for outpatients. Spinal anesthesia was administered to 20 patients, aged between 2 months and 2 years, premedicated with 0.5 mg/kg midazolam + 5 mg/kg ketamine + 0.02 mg/kg atropine rectally. During vein puncture 14 children were asleep, 5 children were anxious and 1 child was crying and during spinal anesthesia 7 children were asleep, 10 children were anxious …
The Comparison Of The Efficacy Aerobic Exercisesversus Strengthening, Stretching Andmobilization Exercises In Subacute And Chroniclow Back Pain, Ayşe Karan, Lütfi̇ye Müslümanoğlu, Semi̇h Aki, Mustafa Fi̇li̇z, Emel Özcan Yildiz, Ender Berker
The Comparison Of The Efficacy Aerobic Exercisesversus Strengthening, Stretching Andmobilization Exercises In Subacute And Chroniclow Back Pain, Ayşe Karan, Lütfi̇ye Müslümanoğlu, Semi̇h Aki, Mustafa Fi̇li̇z, Emel Özcan Yildiz, Ender Berker
Turkish Journal of Medical Sciences
The aim of this study was to investigate and compare the efficacy of aerobic exercises versus strengthening, stretching and mobilization exercises in patients with subacute or chronic low back pain. Forty patients were recruited for the study and randomly allocated to two groups. All patients were evaluated at admission, mid-treatment and termination of the program by visual analog scale (VAS), face scale, weekly analgesic intake and Million visual analog scale for pain. They were also scored by Roland-Morris scale and Oswestry scale for functional impairment. Beck depression inventory was used to evaluate depression and lumbar range of motion was measured …
The Evaluation Of Elongated Styloid Process In Panoramic Radiographs In Edentulous Patients, Memduha Gülhal Bozkir, Hasan Boğa, Fahri̇ Dere
The Evaluation Of Elongated Styloid Process In Panoramic Radiographs In Edentulous Patients, Memduha Gülhal Bozkir, Hasan Boğa, Fahri̇ Dere
Turkish Journal of Medical Sciences
It has been estimated that between 2% to 28% of the general adult population has radiographic evidence of elongated styloid process. In adults, the mean radiographic lenght of the styloid process is 20 to 30 mm and its tip is located between the external and internal carotid arteries, just lateral to the tonsillar fossa. Eagle's syndrome occurs when an elongated styloid process or ossified stylohyoid ligament causes recurrent throat pain or foreign body sensation, dysphagia, or facial pain. It may develop inflammatory changes or impinge on the adjacent arteries or sensory nerve endings, leading to the symptoms described. To study …
Accuracy Of Sphygmomanometers, Okay Başak, Şebnem Karazeybek
Accuracy Of Sphygmomanometers, Okay Başak, Şebnem Karazeybek
Turkish Journal of Medical Sciences
One of the factors affecting the accuracy of readings of blood pressure is the equipment used. Defects or inaccuracy of aneroid sphygmomanometers may be source of error in blood pressure measurement. We inspected 100 sphygmomanometers for physical defects and assessed their accuracy against a standard mercury manometer at four different pressure points. 46 of the 100 sphygmomanometers were determined to be intolerant (deviation from the mercury manometer by greater than±3 mm Hg at two or more of the test points). There were faults in the inflation-deflation system of 34 sphygmomanometers. The most common physical defects were: defective pump bulb, defective …
Chromosome 2 Fragility- 48, Xxyy Syndrome, Öztürk Özdemi̇r, E. Ferda Perçi̇n, İlhan Sezgi̇n
Chromosome 2 Fragility- 48, Xxyy Syndrome, Öztürk Özdemi̇r, E. Ferda Perçi̇n, İlhan Sezgi̇n
Turkish Journal of Medical Sciences
No abstract provided.
Diastolic Dysfunction: Pathogenesis, Therapy Andthe Importance Of Doppler Echocardiography, Fati̇h Yalçin, James Thomas
Diastolic Dysfunction: Pathogenesis, Therapy Andthe Importance Of Doppler Echocardiography, Fati̇h Yalçin, James Thomas
Turkish Journal of Medical Sciences
Diastolic dysfunction is characterized by increased resistance to ventricular filling, inappropriate upward shift of the diastolic pressure-volume relationship and exercise intolerance. Inappropriate tachycardia, decreased diastolic compliance and impaired systolic relaxation lead to diastolic dysfunction. Optimal therapy will depend on the type and pathophysiologic phase of disease. Doppler echocardiography is a valuable tool to diagnose diastolic dysfunction and therapeutic effects of drugs on diastolic function in different groups of patients. Recently a lot of studies have been going on this subject.
Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey
Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey
Turkish Journal of Medical Sciences
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is an integral part of the body's calcium regulatory system. Mammalian and avian VDR genes were isolated, sequenced and characterized. In this study we cloned the vitamin D receptor from amphibians. We received a cDNA library prepared from amphibian (frog) tissues and prepared a cDNA probe based on the avian VDR. We screened the library and located the positive clones. Complete structure of VDR gene has been compared with other species and concluded that it shares 79%, 73%, 73% and 75% identity at the aminoacid level with the …
The Effect Of Dietary Calcium Intake On Plasma Renin Activity And Parathormon In Deoxycorticosteron Salt Hypertension, Ali̇ Gözey, Besi̇m Özaykan, Sai̇me Paydaş, Ayşe Doğan
The Effect Of Dietary Calcium Intake On Plasma Renin Activity And Parathormon In Deoxycorticosteron Salt Hypertension, Ali̇ Gözey, Besi̇m Özaykan, Sai̇me Paydaş, Ayşe Doğan
Turkish Journal of Medical Sciences
The effects of diets containing 2% and 4% calcium (Ca) on deoxycorticosteron (DOC) salt hypertension were studied in 29 male rats weighting 210-260 g. Rats were categorized into four groups: Group I: control rats (6), group II: DOC hypertensive group (n=8), group III: DOC-low Ca diet (2% CaCl 2 ) (8) and group IV: DOC-high Ca diet (4% CaCl_2 ) (n=7). During the six weeks follow up period, indirect systolic blood pressure (SBP) was highest in group II while it was found to be less increased in group III and IV. Weight increase was lowest in group IV (P
The Therapeutic Effect Of Nifedipine As A Ca+2entry Blocker On Experimental Transientischemic Retina, Murat Kaya, Cemal Gündoğdu
The Therapeutic Effect Of Nifedipine As A Ca+2entry Blocker On Experimental Transientischemic Retina, Murat Kaya, Cemal Gündoğdu
Turkish Journal of Medical Sciences
We evaluated the effect of nifedip-ine, an L-type voltage sensitive Ca+2 channel (VSCC) blocker, on the onset of neuronal damage induced by transient ischemia of guinea pig retinas in vivo. The animals were divided into two groups. In the first group 2 mg/kg Nifedipine was administered intraperi-toneally, while only 2 cc/kg NaCl 0.9% solution was given to the second group thirty minutes before the ischemic insult. Seven days after the temporary ligation of bilateral common carotid arteries for 45 minutes, the animals were dispatched and the eyes were enucleated for histopathologic analysis. It was observed that in the Nifedipine treated …
Teratogenic Effects Of Electromagnetic Fields Onthe Skeletal Systems Of Rat Fetuses, Hi̇kmet Hassa, Ömer T. Yalçin, Ni̇lgün Basmak, Hamza Esen, Duygu Koyuncu, Nevi̇n Kurtdere, Reşat N. Aşti
Teratogenic Effects Of Electromagnetic Fields Onthe Skeletal Systems Of Rat Fetuses, Hi̇kmet Hassa, Ömer T. Yalçin, Ni̇lgün Basmak, Hamza Esen, Duygu Koyuncu, Nevi̇n Kurtdere, Reşat N. Aşti
Turkish Journal of Medical Sciences
OBJECTIVE: To evaluate the potential teratogenic effects of electromagnetic fields on the skeletal systems of rat fetuses. MATERIAL AND METHODS: Twenty-five pregnant rats, which had been exposed to electromagnetic fields with frequencies of vertical 50 Hz and horizontal 20 kHz and a total maximum intensity of 10 milligauss, during their pregnancies, were the study group, while 15 pregnant rats were the control group. One hunderd eighty-nine and 125 fetuses obtained from the study and the control group respectively, were evaluated for abnormalities and variations in the skeletal system. The chi-square test was used for the statistical analysis. RESULTS: Major abnormality, …
The Prevalance Of Diseases With Diarrhoeaamong Children Under Five Years Old In Differentsocio-Economical Levels, Ali̇ İhsan Bozkurt, Servet Özgür, Bi̇rgül Özçirpici
The Prevalance Of Diseases With Diarrhoeaamong Children Under Five Years Old In Differentsocio-Economical Levels, Ali̇ İhsan Bozkurt, Servet Özgür, Bi̇rgül Özçirpici
Turkish Journal of Medical Sciences
This study was carried out on a representative sample consisting of 429 households in Gaziantep. The prevalance of diseases with diarrhoea was found to be 22.9% among children under five years old in the two weeks preceding the survey. It was observed that 51.3% of children with diarrhoea were taken to a medical facility, the mean duration of the diarrhoea was 4.5±3.8 days, and the rate of children with diarrhoea during the preceding 24 hours was 11.8%. It was also determined that the rate of children with diarrhoea whose intake of fluids was increased was 65.1%, the ratio of children …
Treatment Of Cervical Spondylosis By Anteriorsubtotal Vertebrectomy And Iliac Bone Fusion, Mehmet Yaşar Kaynar, Pami̇r Erdi̇nçler, Ali̇ Kafadar, Murat Hanci, Emi̇n Özyurt, Ali̇ Çeti̇n Sarioğlu
Treatment Of Cervical Spondylosis By Anteriorsubtotal Vertebrectomy And Iliac Bone Fusion, Mehmet Yaşar Kaynar, Pami̇r Erdi̇nçler, Ali̇ Kafadar, Murat Hanci, Emi̇n Özyurt, Ali̇ Çeti̇n Sarioğlu
Turkish Journal of Medical Sciences
There is no ideal surgical technique for cervical spondylosis. The choice of surgical procedure remains controversial. A series of 25 patients who had undergone subtotal vertebrectomy and iliac bone fusion between 1985 and 1995 were reviewed. There were 19 men and 6 women with an average age of 55.6 years. All of the patients had cervical myelopathy and /or radiculopathy due to multi-level spondylosis and 7 with associated ossification of the posterior longitudinal ligament. In 6 patients 1 vertebral body, in 10 patients 2 vertebral bodies, and in 9 patients 3 vertebral bodies were resected. After a mean 15-month follow-up …
Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç
Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç
Turkish Journal of Medical Sciences
The anatomical variations of the brachial plexus in human have clinical significance to surgeons, radiologists and anatomists. We studied some variations in the formation of 130 brachial plexuses in sixty-five infant cadavers (34 males, 31 females; aged 1-7 days). The brachial plexus consisted of the 5 th , 6 th , 7 th , and 8 th cervical spinal nerves and 1 st thoracic spinal nerve (69.23%). We found that among the 130 plexuses, 30.77% also received a contribution from C4 (Fig.1, A ) . The variations in the formation of brachial plexuses were classified into three groups. Group 1 …
Non-Gestational Impetigo Herpetiformis, Teoman Erdem, Ali̇ Karakuzu, Muammer Parlak, Necmetti̇n Akdeni̇z
Non-Gestational Impetigo Herpetiformis, Teoman Erdem, Ali̇ Karakuzu, Muammer Parlak, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
No abstract provided.
Significance Of Cardiac Troponin T Release In Detecting Minor Myocardial Injury After Percutaneous Transluminal Coronary Angioplasty, Güli̇nnaz Alper, Taner Onat, Ömür Erkizan, Fi̇li̇z Özerkan, Azem Akilli
Significance Of Cardiac Troponin T Release In Detecting Minor Myocardial Injury After Percutaneous Transluminal Coronary Angioplasty, Güli̇nnaz Alper, Taner Onat, Ömür Erkizan, Fi̇li̇z Özerkan, Azem Akilli
Turkish Journal of Medical Sciences
Cardiac Troponin T (TnT) is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. This study was designed to evaluate the diagnostic efficiency of TnT enzyme immunoassay in detecting myocardial damage in patients with stable angina pectoris undergoing visually successful percutaneous transluminal coronary angioplasty (PTCA) and to compare this newly developed test with the conventionally used cardiac enzyme tests. The study population consisted of 24 patients (3 females and 21 males) with a mean age of 55±9 years. Serial blood samples …
The Effect Of Lead Inhalation On Rat Lungmorphology, Bi̇lge Onarlioğlu, Turhan Onarlioğlu, Sena Erdal
The Effect Of Lead Inhalation On Rat Lungmorphology, Bi̇lge Onarlioğlu, Turhan Onarlioğlu, Sena Erdal
Turkish Journal of Medical Sciences
Lead may exert toxic effects on several organ systems, but those in the lung are the most insidious. Therefore the aim of the present study was to investigate the morphological alterations caused by lead intoxication in rat lungs. Twenty-five Wistar albino rats were divided into three groups: the control group consisted of five animals while the experimental groups contained ten animals each. The control group animals were not subjected to lead treatment, whereas the first experimental group animals were exposed to 500 \mug /0.1 m 3 /day of lead for one week, and the second group had the same dosage …
Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek
Oxidative Damage In Erythrocytes During Cold Storage With Organ Preservation Solution, Aki̇f B. Memmedoğlu, Ahmet Özaydin, İsmai̇l Seçki̇n, Gönül Sultuybek
Turkish Journal of Medical Sciences
It is known that erythrocyte aggregation in renal tissue during preserva-tion is cause of microcirculation defects in the reperfusion period. The aim of our study is to investigate oxidative damage in erythrocytes relative to the time of cold ischemia during organ preservation and relationship between lipid peroxidation and development of these damages. In experiments with a rabbit model, explanted kidneys were exposed to perfusion and 96 hours preservation with Euro-Collins (EC) in the 1st group, and University of Wisconsin (UW) solution in the 2nd group. Electron-microscopic examinations in renal tissueswere performed. Lipid peroxidation and glutathione levels in erythrocytes preserved in …
Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu
Action Of Aspirin On Acetylcholine-Stimulatedtear Secretion In Rats, Zerri̇n Kapicioğlu, Gamze Çan, I. Nuri̇ Kalyoncu
Turkish Journal of Medical Sciences
In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received 60mg/kg of ASA and 30 min …