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Articles 631 - 660 of 8080
Full-Text Articles in Medicine and Health Sciences
Impact Of Black Soldier Fly (Hermetia Illucens) Fresh Meal On The Growth Performance, Digestive Enzymes, Hematology, And Intestinal Histology Of Cork Fish (Channa Striata), Boby Muslimin, Danang Yonarta, Eny Heriyati, Helmizuryani Helmizuryani, Meika Puspita Sari, Dewi Apriyanti, Rahmat Kurniawan
Impact Of Black Soldier Fly (Hermetia Illucens) Fresh Meal On The Growth Performance, Digestive Enzymes, Hematology, And Intestinal Histology Of Cork Fish (Channa Striata), Boby Muslimin, Danang Yonarta, Eny Heriyati, Helmizuryani Helmizuryani, Meika Puspita Sari, Dewi Apriyanti, Rahmat Kurniawan
Turkish Journal of Veterinary & Animal Sciences
Black Soldier Fly (BSF) is an alternative ingredient for Fish Meal (FM) which is expected to reduce aquaculture operational costs and positively impact fish growth and health. The effect of BSF fresh meal on growth response, digestibility, intestinal hematology, and intestinal histology of cork fish was investigated. The BSF experiment with mixed percentages as treatments, by 20%, 50%, 80%, and 100%, was repeated four times. Furthermore, there were 50 individuals/m3 cork fish with an average weight of 1.6 ± 0.05 g distributed in each treatment. An increase in BSF influences a significant decrease in the Relative Growth Weight (RGW) and …
Comparison Of Bacterial Profile And Antibiotic Susceptibility Isolated From Surgical Site After Ventral Midline And Lateral Flank Approaches Of Ovariohysterectomy In Queens And Bitches, Ebru Karakaya Bi̇len, Serpi̇l Kahya Demi̇rbi̇lek, Öznur Yilmaz, Muhammet Ali̇ Karadağ, Havva Aner
Comparison Of Bacterial Profile And Antibiotic Susceptibility Isolated From Surgical Site After Ventral Midline And Lateral Flank Approaches Of Ovariohysterectomy In Queens And Bitches, Ebru Karakaya Bi̇len, Serpi̇l Kahya Demi̇rbi̇lek, Öznur Yilmaz, Muhammet Ali̇ Karadağ, Havva Aner
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to identify the bacterial profile and antimicrobial susceptibility from surgical site cultures in queens and bitches undergoing ovariohysterectomy via ventral midline and lateral flank approaches. Healthy 22 queens and 21 bitches were assigned randomly either ventral midline or lateral flank approach for routine ovariohysterectomy. Surgical site samples were collected before the surgery and on the 1$^{st}$, 2$^{nd}$ , and 3 $^{rd}$days after the surgery for microbiological analysis. A total of 70 different strains were isolated from 50 (29%) of 172 samples. In both queens and bitches the total number of bacteria isolated from the …
Determination Of Virulence Genes And Antibiotic Resistance Profiles Of Streptococcus Agalactiae Isolated From Buffalo Milk, Nevi̇n Tuzcu, Hasan Hüseyi̇n Hadi̇mli̇, Beatri̇z Padron
Determination Of Virulence Genes And Antibiotic Resistance Profiles Of Streptococcus Agalactiae Isolated From Buffalo Milk, Nevi̇n Tuzcu, Hasan Hüseyi̇n Hadi̇mli̇, Beatri̇z Padron
Turkish Journal of Veterinary & Animal Sciences
Mastitis is a contagious disease that causes significant milk loss and serious economic damage in dairy animals. Streptococcus agalactiae causes clinical and subclinical mastitis in animals and infections in humans, especially adults, and newborns. This study aimed to confirm the identification of S. agalactiae isolates by PCR in buffalo milk; to determine the antibiotic resistance and virulence genes by multiplex PCR. The material of this study consisted of 30 (12%) S. agalactiae strains identified by phenotypic, biochemical, and PCR methods (rRNA-16S) from 250 isolates with bacterial growth from milk samples of buffaloes with mastitis. In addition, the Kirby-Bauer disc diffusion …
Effect Of Feeding Frequency On Growth, Fecundity, And Meat Quality Of Abant Trout (Salmo Abanticus Tortonese, 1954) Broodstock, Mehmet Zeki̇ Alkan, Nadi̇r Başçinar
Effect Of Feeding Frequency On Growth, Fecundity, And Meat Quality Of Abant Trout (Salmo Abanticus Tortonese, 1954) Broodstock, Mehmet Zeki̇ Alkan, Nadi̇r Başçinar
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to investigate the growth data, egg production and changes in the biochemical structure of meat of Abant trout depending on feeding frequency (once a day, twice a day, three times a day, four times a day) in order to contribute to the economy through the private sector. All fish in the groups were planned to be of similar weight at the beginning of the study. Individual fish weights were measured at the beginning of the study, and the average was found to be 224.87 ± 0.69 g. At the end of the study, the weights …
Stereological Investigation Of Medulla Oblongata Volume In Norduz Sheep, Ozan Ertaş, Gamze Çakmak
Stereological Investigation Of Medulla Oblongata Volume In Norduz Sheep, Ozan Ertaş, Gamze Çakmak
Turkish Journal of Veterinary & Animal Sciences
In this study, it was aimed to stereologically examine the medulla oblongata volume of Norduz sheep in the Gürpınar District of Van Province. Upon receiving news from the sections in the Gürpınar region, we went to the region. A total of 12 Norduz sheep skulls, 6 females and 6 males, were received from the Norduz sheep slaughter in the region. After the brains of Norduz sheep were dissected, they were fixed as a whole in formaldehyde for 1 week. Medulla oblongatas were separated from the brain and kept in formaldehyde for 1 week. Tissues obtained by sequential random sampling from …
In Vitro Antimicrobial And Antibiofilm-Forming Activities Of Origanum Munzurense Plant Extract On Some Foodborne Gram-Negative Bacteria, Hali̇l Yalçin, Esra Zeybek, Oktay Özkan, Asim Kart
In Vitro Antimicrobial And Antibiofilm-Forming Activities Of Origanum Munzurense Plant Extract On Some Foodborne Gram-Negative Bacteria, Hali̇l Yalçin, Esra Zeybek, Oktay Özkan, Asim Kart
Turkish Journal of Veterinary & Animal Sciences
lants are an important source for the discovery of antimicrobial formulations due to the many biologically active components they contain. In this study, in vitro antimicrobial and antibiofilm forming activities of ethanolic extract of Origanum munzurense were investigated against some strains of foodborne pathogenic bacteria. To investigate the antimicrobial activity, the minimal inhibitory concentration values against the selected bacteria and antibiofilm-forming activity were tested with the liquid microdilution method and microplate method, respectively. MICs of Origanum munzurense extract against the bacteria tested are 32 mg/mL for Escherichia coli O157: H7 ATCC 35150, 32 mg/mL for Escherichia coli O157: H7 ATCC …
Evaluation Of Different Stocking Densities On Fattening Performance, Slaughter, Carcass, Meat Quality Characteristics, And Fatty Acid Composition In New Zealand Rabbits, Büşra Yaranoğlu, Mustafa Hi̇lmi̇ Yaranoğlu, Sali̇ha Uysal, Adnan Adi̇l Hi̇şmi̇oğullari
Evaluation Of Different Stocking Densities On Fattening Performance, Slaughter, Carcass, Meat Quality Characteristics, And Fatty Acid Composition In New Zealand Rabbits, Büşra Yaranoğlu, Mustafa Hi̇lmi̇ Yaranoğlu, Sali̇ha Uysal, Adnan Adi̇l Hi̇şmi̇oğullari
Turkish Journal of Veterinary & Animal Sciences
The aim of the research was to investigate the effects of different stocking densities on fattening performance, slaughter, carcass, meat quality characteristics, and fatty acid composition in New Zealand rabbits raised in cage conditions and also determine the ideal housing frequency so that yields were not adversely affected. In the study, 36 New Zealand rabbits were used. After weaning, the fattening was started and rabbits were put into cages at different stocking densities as 1 rabbit/cage, 2 rabbits/cage, and 3 rabbits/ cage. The live weight of rabbits and feed consumption data were taken every week. At the end of 8 …
The First Data Of A Newly Recorded Native Goat Genotype Called Manavlı In Türkiye: Growth Traits Of Kids, Aykut Asim Akbaş, Mustafa Saatci, Özkan Elmaz, Can Meti̇n Yazici
The First Data Of A Newly Recorded Native Goat Genotype Called Manavlı In Türkiye: Growth Traits Of Kids, Aykut Asim Akbaş, Mustafa Saatci, Özkan Elmaz, Can Meti̇n Yazici
Turkish Journal of Veterinary & Animal Sciences
This study aimed to define growth traits of kids named Manavlı goat from six flocks under the breeder?s conditions in Denizli Province. The average birth weights of the kids were 3.63 kg, 4.28 kg, 3.85 kg, 4.11 kg, 3.83 kg, and 3.64 kg for the six flocks, respectively. The average live weights of male and female kids on 60th, 90th, and 150th day of age were 16.50 kg, 22.35 kg, and 34.82 kg and 15.33 kg, 20.14 kg, and 32.06 kg, respectively (p < 0.05). While the average live weights of single kids on 60th, 90th were 16.70 kg and 21.96 kg, the values for twins were 15.13 kg and 21.03 kg, respectively (p < 0.05). Body measurements of male kids such as height at withers, rump height, rump width, body length, heart girth, head length, ear length, tail length, and front and back wrist girth were measured as 70.26 cm, 70.21 cm, 16.23 cm, 66.80 cm, 70.11 cm, 19.51 cm, 22.16 cm, 18.59 cm, 11.85 cm, and 11.57 cm, respectively, on the 150th day of age. This study is the first research related to growth traits of Manavlı kids, for which no features have been reported to date. It was thought that the results obtained will help to characterise the Manavlı goat and will provide a database for the following studies.
Expression Of Hif-1Α, Caspase-3, P53, Hsp70, Hsp90, And Nrf2 In The Canine Spleen With Siderofibrotic Nodules: An Immunohistochemical And Immunofluorescence Perspective On Apoptosis, Ferroptosis, And Oxidative Stress, Ali Babanezhad-Gajouti, Amir Amniattalab
Expression Of Hif-1Α, Caspase-3, P53, Hsp70, Hsp90, And Nrf2 In The Canine Spleen With Siderofibrotic Nodules: An Immunohistochemical And Immunofluorescence Perspective On Apoptosis, Ferroptosis, And Oxidative Stress, Ali Babanezhad-Gajouti, Amir Amniattalab
Turkish Journal of Veterinary & Animal Sciences
Splenic siderofibrotic nodules (SFNs) are benign tiny yellow-brownish foci found in dogs. Their pathogenesis is unclear whereas trauma and hemorrhage are assumed to be the possible causative factors. The spleen of 73 Iranian dogs of the mixed breed was examined for possible splenomegaly with SFNs. Ultrasonography, blood biochemistry, pathology, and immunohistochemistry revealed splenomegaly (n = 7), splenomegaly with SFNs (n = 6) and normal spleens (n = 60). There was no significant difference between the prevalence of splenomegaly with SFN among the examined dogs and their age or sex (p > 0.05). Ultrasonography represented a significant increase (p ≤ 0.01) in …
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Turkish Journal of Medical Sciences
Background/aim: This experimental study aimed to define a biochemical marker that will enable early diagnosis of acute compartment syndrome (ACS) of extremities, a mortal condition that occurs due to trauma. Materials and methods: A total of 15 Wistar rats were included in the study in which saline infusion technique, a clinically compatible ACS model, was applied. After the rats were anesthetized with ketamine-xylazine, the in-compartment pressure of the hind limb was slowly increased with saline delivered through the angiocatheter, and after reaching the target compartment pressure, the pressure level was kept with a rubber tourniquet. The in-compartment pressure level was …
Effect Of Crocin And Losartan On Biochemical Parameters And Genes Expression Of Frmd3 And Bmp7 In Diabetic Rats, Yaser Mohammadi, Mohammad Zangooei, Fatemeh Salmani, Azam Rezaei Farimani
Effect Of Crocin And Losartan On Biochemical Parameters And Genes Expression Of Frmd3 And Bmp7 In Diabetic Rats, Yaser Mohammadi, Mohammad Zangooei, Fatemeh Salmani, Azam Rezaei Farimani
Turkish Journal of Medical Sciences
Background/aim: Diabetes is a multifactorial and growing disease, one of the severe complications of which is diabetic nephropathy (DN), which is the most common cause of chronic renal failure. FERM domain containing 3 (FRMD3) is responsible for maintaining the shape and integrity of nephron cells, and bone morphogenetic protein 7 (BMP7) helps maintain function and reduce kidney damage. This study aimed to evaluate the effect of crocin and losartan on biochemical parameters and the expression of FRMD3 and BMP7 genes in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Forty male Wistar rats were randomly divided into five experimental groups as …
Effects Of Recurrent Ketamine Exposure On Brain Histopathology In Juvenile Rats, Ayşe Hande Arpaci, Süheyla Esra Özkoçer, Emel Güneş, Çi̇ğdem Elmas, Berri̇n Işik
Effects Of Recurrent Ketamine Exposure On Brain Histopathology In Juvenile Rats, Ayşe Hande Arpaci, Süheyla Esra Özkoçer, Emel Güneş, Çi̇ğdem Elmas, Berri̇n Işik
Turkish Journal of Medical Sciences
Background/aim: Ketamine (KET) is a commonly used anesthetic agent. However, several previous studies reported that KET leads to neuronal damage in neurodevelopmental stages and has neuroprotective effects. The present experimental study aimed to determine the undesirable histopathological effects of KET in the cerebral cortex, striatum, and hippocampus after recurrent KET administration in juvenile rats. Materials and methods: After ethical approval was obtained, 32 juvenile male Wistar Albino rats were randomized into four groups: 1 mg/kg serum saline intraperitoneally (i.p.), 5 mg/kg KET i.p., 20 mg/kg KET i.p., and 50 mg/kg KET i.p. KET was administered for three consecutive days at …
Investigation Of Taurine And Aqueous Garlic Extract Diet Supplementation Effect On The Healing Of Rat Osteoporotic Fractures, Mesut Misirlioğlu, İzzet Bi̇ngöl, Coşkun Genç, Ayli̇n Akbulut, Mert Ocak, Nezi̇ha Yağmur Di̇ker, Ahmet Özmeri̇ç, Gökhan Koca, Meli̇ke Bahçeci̇tapar, Mehmet Şeneş, Ayşegül Firat, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k, İffet İrem Çankaya, Meli̇ha Korkmaz
Investigation Of Taurine And Aqueous Garlic Extract Diet Supplementation Effect On The Healing Of Rat Osteoporotic Fractures, Mesut Misirlioğlu, İzzet Bi̇ngöl, Coşkun Genç, Ayli̇n Akbulut, Mert Ocak, Nezi̇ha Yağmur Di̇ker, Ahmet Özmeri̇ç, Gökhan Koca, Meli̇ke Bahçeci̇tapar, Mehmet Şeneş, Ayşegül Firat, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k, İffet İrem Çankaya, Meli̇ha Korkmaz
Turkish Journal of Medical Sciences
Background/aim: We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods: In this experimental animal study,twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results: As an indicator of …
The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar
The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar
Turkish Journal of Medical Sciences
Background/aim: Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects of paclitaxel. Although curcumin is an antioxidant, data concerning the effect of curcumin on paclitaxel-induced testis tissue are lacking. The present study was established to examine the protective impact of curcumin against testicular damage induced by paclitaxel. Materials and methods: In the study, 40 Wistar albino male rats were used and randomly divided into 4 groups (n:10). The control group received only saline solution; the …
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
Turkish Journal of Medical Sciences
Background/aim: In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods: Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of …
Evaluation Of The Effects Of Three Natural Products And A Hemostatic Agent On Wound Healing: An Experimental Study, Ayşe Çeli̇k Yilmaz, Di̇lek Aygi̇n
Evaluation Of The Effects Of Three Natural Products And A Hemostatic Agent On Wound Healing: An Experimental Study, Ayşe Çeli̇k Yilmaz, Di̇lek Aygi̇n
Turkish Journal of Medical Sciences
Background/aim: People have used many natural materials such as plant leaves, roots, liquids derived from plants, and animal products to treat wounds throughout history. It can be said that the research on wound care in recent years have focused on traditional and natural products again. This study aimed to investigate the effects of sweetgum oil, propolis, silk protein, and Ankaferd Blood Stopper (ABS) on wound healing in an experimental excisional wound model. Materials and methods: Including 36 Balb/c inbreed mice in the study were divided equally into four groups. Two circular excisional wounds were created on the dorsal skin of …
Is Advanced Bipolar Vessel Sealing Device Really Effective In Decreasing The Pelvic Lymphocele Ratio In Open Surgery For Endometrial Cancer?, Mehmet Ali̇ Nari̇n, Sevda Baş, Sevtap Seyfetti̇noğlu, Tuba Yar, Razi̇ye Nari̇n
Is Advanced Bipolar Vessel Sealing Device Really Effective In Decreasing The Pelvic Lymphocele Ratio In Open Surgery For Endometrial Cancer?, Mehmet Ali̇ Nari̇n, Sevda Baş, Sevtap Seyfetti̇noğlu, Tuba Yar, Razi̇ye Nari̇n
Turkish Journal of Medical Sciences
Background/aim: We aim to show pelvic lymphocele (PL) rates in patients who were operated for endometrial cancer (EC) and underwent systematic paraaortic bilateral pelvic lymph node dissection (PABPLND) with advanced bipolar vessel sealing device (ABVSD) Materials and methods: The medical files of all patients who underwent open surgery for EC between January 2017 and December 2021 were retrospectively analyzed. One hundred three patients who operated with the diagnosis of high-intermediate and high-risk endometrial cancer were included. Systematic PABPLND was performed with total abdominal hysterectomy with or without bilateral salpingo-oophorectomy during surgery to all patients. All operations were performed by same …
Primary Versus Secondary Intraocular Lens Implantation Following Removal Of Congenital/Developmental Cataracts: Outcomes After At Least 4 Years, Ayşi̇n Tuba Kaplan, Si̇bel Öskan Yalçin, Ayşe Yeşi̇m Oral
Primary Versus Secondary Intraocular Lens Implantation Following Removal Of Congenital/Developmental Cataracts: Outcomes After At Least 4 Years, Ayşi̇n Tuba Kaplan, Si̇bel Öskan Yalçin, Ayşe Yeşi̇m Oral
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the long-term outcomes of primary and secondary intraocular lens (IOL) implantation following removal of congenital/developmental cataracts. Materials and methods: One hundred and forty-four patients aged under 16 years who were followed up between 2003 and 2021 were analyzed retrospectively. The long-term results of children who underwent surgery before 2 years of age for congenital or developmental cataracts and underwent secondary IOL implantation after 2 years of age and those who underwent cataract surgery with primary IOL implantation after 2 years of age were compared. Patients with traumatic, secondary cataracts and cataracts …
Postnatal Surgery For Myelomeningocele In Neonates: Neurodevelopmental Outcomes, Melek Akar, Gülşah Çeti̇n, Mi̇ne İnal, Mehmet Helvaci, Ni̇hal Olgaç Dündar, Firat Ergi̇n, Özgün Uygur, Si̇nem Akbay, Nai̇l Özdemi̇r, Meltem Koyuncu Arslan, Mehmet Yekta Öncel
Postnatal Surgery For Myelomeningocele In Neonates: Neurodevelopmental Outcomes, Melek Akar, Gülşah Çeti̇n, Mi̇ne İnal, Mehmet Helvaci, Ni̇hal Olgaç Dündar, Firat Ergi̇n, Özgün Uygur, Si̇nem Akbay, Nai̇l Özdemi̇r, Meltem Koyuncu Arslan, Mehmet Yekta Öncel
Turkish Journal of Medical Sciences
Background/aim: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period. Materials and methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. Neurodevelopmental outcomes of term neonates operated for MMC and healthy term newborns were compared with the Bayley Scales of Infant and Toddler Development -Third Edition (BSID III) at 12-18 months. Results: A total of 57 cases were included in the study (patient group = 27; control group = 30). Demographic data between the groups were similar. Cognitive, linguistic, and motor composite scores of the patient …
Transbronchial Lung Cryobiopsy For The Diagnosis Of Diffuse Parenchymal Lung Disease: Pitfalls And Challenges, A Single Center Experience, Kemal Can Tertemi̇z, Ayli̇n Özgen Alpaydin, Nurcan Güler, Volkan Karaçam, Duygu Gürel, Naci̇ye Si̇nem Gezer
Transbronchial Lung Cryobiopsy For The Diagnosis Of Diffuse Parenchymal Lung Disease: Pitfalls And Challenges, A Single Center Experience, Kemal Can Tertemi̇z, Ayli̇n Özgen Alpaydin, Nurcan Güler, Volkan Karaçam, Duygu Gürel, Naci̇ye Si̇nem Gezer
Turkish Journal of Medical Sciences
Background/aim: Transbronchial lung cryobiopsy (TBLC) is a minimally invasive technique of the diagnosis of diffuse parenchymal lung diseases (DPLD). The aim of this study is to determine the clinical-radiological and histopathological characteristics of patients in whom cryobiopsy contributes to the diagnosis. Materials and methods: In this retrospective study, we searched for the medical records of patients who underwent TBLC from July 2015 to March 2020 at the pulmonology department of our university hospital clinic. Radiological images were evaluated by a chest radiologist experienced in DPLD. Prediagnosis was indicated by clinical-radiological findings. The final diagnosis was determined by the contribution of …
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Turkish Journal of Medical Sciences
Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. …
A New Method For Second Toe Flap Revascularization In Plantar Dominant Artery Pattern - Dorsal Metatarsal Artery Interpositional Graf, Erhan Sönmez, Ersi̇n Akşam, İlker Uyar
A New Method For Second Toe Flap Revascularization In Plantar Dominant Artery Pattern - Dorsal Metatarsal Artery Interpositional Graf, Erhan Sönmez, Ersi̇n Akşam, İlker Uyar
Turkish Journal of Medical Sciences
Background/aim: Toe transfer to hand is a viable option for patients, which can provide functionally useful digits. Harvesting of the second toe is still accepted as a demanding surgical procedure. The major questions before this transfer are the location and the dominance of the arterial anatomy of the second toe. The authors present the incidence of patients with a dominant plantar artery system and a description of a versatile technique that can be used for toe transfers in these patients. Materials and methods: The study was designed retrospectively. Toe to hand transfers performed between 2010 and 2018 were reviewed. The …
Effects Of Breast Milk On Behçet's Disease Clinical Features, Hati̇ce Ecem Konak, Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Hakan Apaydin, Pinar Akyüz Dağli, Yağnur Uzun, Merve Kaygisiz, Orhan Küçükşahi̇n, Ahmet Omma
Effects Of Breast Milk On Behçet's Disease Clinical Features, Hati̇ce Ecem Konak, Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Hakan Apaydin, Pinar Akyüz Dağli, Yağnur Uzun, Merve Kaygisiz, Orhan Küçükşahi̇n, Ahmet Omma
Turkish Journal of Medical Sciences
Background/aim: The etiology of Behçet's disease (BD) is not clearly known, however, abnormal activity in T helper (Th) 1, Th 17, and regulatory T cells (Treg) has critical importance in pathogenesis. It has been shown that the intestinal microbiome can be effective in the modulation of these immune abnormalities in BD patients. Breastfeeding increases the maturation of the infant's intestinal permeability by affecting the newborn's immature intestinal microbiome and metagenome. We aimed to examine the effects of breastfeeding on disease related symptoms, organ involvements and course of the disease in BD patients. Materials and methods: This study was designed as …
Decreased Circulating Microrna-21 And Microrna-143 Are Associated To Pulmonary Hypertension, Zekeri̇ya Düzgün, Lati̇fe Meral Kayikçioğlu, Çağdaş Aktan, Buşra Bara, Fatma Zuhal Eroğlu, Burcu Yağmur, Vi̇ldan Bozok Çeti̇ntaş, Meli̇ke Bayindir, Sanem Nalbantgi̇l, Asli Teti̇k Vardarli
Decreased Circulating Microrna-21 And Microrna-143 Are Associated To Pulmonary Hypertension, Zekeri̇ya Düzgün, Lati̇fe Meral Kayikçioğlu, Çağdaş Aktan, Buşra Bara, Fatma Zuhal Eroğlu, Burcu Yağmur, Vi̇ldan Bozok Çeti̇ntaş, Meli̇ke Bayindir, Sanem Nalbantgi̇l, Asli Teti̇k Vardarli
Turkish Journal of Medical Sciences
Background/aim: Pulmonary arterial hypertension (PAH) is characterized by maladaptation of pulmonary vasculature which is leading to right ventricular hypertrophy and heart failure. miRNAs play a crucial role in the regulation of many diseases such as viral infection, cancer, cardiovascular diseases, and pulmonary hypertension (PH). In this study, we aimed to investigate the expression pattern of eight human plasma miRNAs (hsa-miR-21-3p, hsa-miR-143- 3p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsamiR-206, hsa-miR-210-3p) in mild-to-severe PH patients and healthy controls. Materials and methods: miRNAs were extracted from the peripheral plasma of the PH patients (n: 44) and healthy individuals (n: 30) by using the miRNA …
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the expression of lymphocyte activation gene-3 (LAG-3) and its relationship with programmed cell death ligand-1 (PD-L1) in triple-negative breast cancer (TNBC). Materials and methods: LAG-3 and PD-L1 was evaluated in tumor-infiltrating lymphocytes (TILs) using immunohistochemistry (IHC). The chi-square test was used to estimate the associations between LAG-3, PD-L1 and clinicopathological characteristics. Correlation between LAG-3 stromal TIL (sTIL), LAG-3 intraepitelial TIL (iTIL) and PD-L1 was assessed with using the Spearman's correlation coefficient. Survival analysis was performed using the Kaplan-Meier method. Results: The percentages of LAG-3 sTIL+, LAG-3 iTIL+, PD-L1+ tumor cells and PD-L1+ inflammatory cells …
Expression Of Laminin-1 And Matrix Metalloproteinase-9 In Benign And Malignant Endometrium, Zehra Küçükaydin, Mustafa Başaran, Yaşar Ünlü, Ahmet Başaran, Merti̇han Kurdoğlu
Expression Of Laminin-1 And Matrix Metalloproteinase-9 In Benign And Malignant Endometrium, Zehra Küçükaydin, Mustafa Başaran, Yaşar Ünlü, Ahmet Başaran, Merti̇han Kurdoğlu
Turkish Journal of Medical Sciences
Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues. Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = …
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Turkish Journal of Medical Sciences
Background/aim: In this prospective observational study, we aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy. Materials and methods: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021. Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery …
Significance Of The Immunofluorescence Staining Patterns And Titres Of The Antinuclear Antibody Test In Paediatric Rheumatology Setting, Özge Baba, Hakan Kisaoğlu, Mukaddes Kalyoncu
Significance Of The Immunofluorescence Staining Patterns And Titres Of The Antinuclear Antibody Test In Paediatric Rheumatology Setting, Özge Baba, Hakan Kisaoğlu, Mukaddes Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Antinuclear antibody (ANA) is among the most frequently ordered tests in paediatric rheumatology setting. Diseases like systemic lupus erythematosus and Sjögren syndrome is closely related with a positive ANA and classified as ANA associated diseases. Besides, ANA test is ordered in patients with juvenile idiopathic arthritis (JIA) to assess the risk for uveitis and a positive ANA could be detected in children with nonrheumaticrheumatic conditions. In this study, we aimed to investigate frequency of positive ANA in paediatric rheumatology setting and the association of immunofluorescence staining patterns and titres of ANA with rheumatic diseases. Materials and methods: Immunofluorescence staining …
Psa Change After Antibiotic Treatment Should Not Affect Decision-Making On Performing A Prostate Biopsy, Yunus Kayali, Mevlana Derya Balbay, Abdullah İlktaç, Cevper Ersöz, Hüseyi̇n Toprak, Kayhan Tarim, Arzu Baygül Eden, Muzaffer Akçay, Bayram Doğan
Psa Change After Antibiotic Treatment Should Not Affect Decision-Making On Performing A Prostate Biopsy, Yunus Kayali, Mevlana Derya Balbay, Abdullah İlktaç, Cevper Ersöz, Hüseyi̇n Toprak, Kayhan Tarim, Arzu Baygül Eden, Muzaffer Akçay, Bayram Doğan
Turkish Journal of Medical Sciences
Background/aim: To investigate the effect of antibiotic treatment on PSA when deciding on prostate biopsy. Materials and methods: A total of 206 patients with an elevated PSA level (2.5-30) were included. Mp-MRI could be done on 129 patients. Patients were given ciprofloxacin (500 mg, b.i.d. p.o.) for 4 weeks and PSA measurements were repeated. Systematic prostate biopsy was performed regardless of PSA changes on all patients. Additionally, cognitive biopsies were performed from PI-RADs III, IV, and V lesions. Results: Prostate cancer was detected in 36.4% of patients. 53.3% had Gleason score of 3+3, 46.7% had Gleason score ≥ 3+4. PSA …
Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci
Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci
Turkish Journal of Medical Sciences
Background/aim: Advanced glycation end products receptor (RAGE) is a pattern recognition receptor which attracted attention in chronic airway diseases recently. This study aimed to determine the association of RAGE with asthma and the cellular responses resulting from RAGE signaling pathway activation. Materials and methods: Asthmatic (n = 362) and healthy (n = 134) children were genotyped by PCR-RFLP. Plasma sRAGE levels were determined by ELISA. Lung structural cells were stimulated with AGEs (advanced glycation end products) and control BSA. Expressions of cytokines and protein levels were determined by real-time PCR and ELISA. Results: Gly82Ser and -374 T/A polymorphisms in RAGE …