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Articles 601 - 630 of 8080
Full-Text Articles in Medicine and Health Sciences
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls. Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel …
Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz
Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz
Turkish Journal of Medical Sciences
Background/aim: The pathology of laryngomalacia is still not clear. The aim of this study was to investigate the relationship between vitamin D levels and laryngomalacia, and to evaluate vitamin D levels according to the classification of laryngomalacia. Materials and methods: This retrospective study was conducted in the Kahramanmaraş Sütçü İmam University Medicine Faculty?s Otorhinolaryngology Clinic between June 2014 and January 2021. Laryngomalacia was classified. Laboratory tests for all patients included calcium (Ca), phosphorus (P), parathormone (PTH), blood urea nitrogen (BUN), creatinine (Cre), alanine transaminase (ALT), and 25-hydroxy vitamin D (25-OH-D). Results: Evaluations were performed for 64 infants with laryngomalacia, including …
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Turkish Journal of Medical Sciences
Background/aim: To assess the effects of postweaning social isolation, an enriched environment, and exercise training on learning and memory functions in rats, as well as their relation with the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) concentrations in the hippocampus. Materials and methods: Randomly assigned into 4 groups were 35 female postweaning rats (25 day old), as the control (C), social isolation (SI), enriched environment (EE), and exercise training (E) groups. The SI and the EE groups were housed under their specific conditions and the E and the C groups were housed under standard conditions for 6 weeks. …
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the proliferation and apoptotic effects of extracts from Cornus mas L. and Berberis vulgaris fruits on human breast cancer cells (MCF-7). Materials and methods: The Cornus mas L. and Berberis vulgaris fruits, which constitute the herbal material of the study, were turned into 80% acetone extract after washing. The total phenolic content in Berberis vulgaris fruit extracts was determined calorimetrically using Folin-Ciocalteu reagent. The spectrophotometric method was used to determine the total flavonoid amount of the extracts. In order to measure the antioxidant capacity of Cornus mas L. and Berberis vulgaris fruits and extracts, …
Serum Myosin-Binding Protein C Levels: A New Marker For Exclusion Of Preterm Birth?, Eli̇f Yildiz, Fatma Ketenci̇ Gencer, Burcu Ti̇mur, Hakan Ti̇mur
Serum Myosin-Binding Protein C Levels: A New Marker For Exclusion Of Preterm Birth?, Eli̇f Yildiz, Fatma Ketenci̇ Gencer, Burcu Ti̇mur, Hakan Ti̇mur
Turkish Journal of Medical Sciences
Background/aim: To evaluate whether there is a relationship between serum myosin-binding protein C (MyBP-C) levels measured in the first trimester and the timing of delivery, and, if a relationship is detected, the potential of this relationship in distinguishing between preterm and term labor. Materials and methods: This prospective case-control study was conducted with 701 pregnant women who applied to the Obstetrics Outpatient Clinic of Gaziosmanpaşa Training and Research Hospital in the first trimester, between 11 and 14 gestational weeks. MyBP-C serum samples from the first trimester were stored under appropriate conditions until the time of delivery. Of these pregnant women, …
A Retrospective Study: Can Dual Art Mitigate The Risk Of Potential Drug-Drug Interactions Among Plwh Under Stable Art?, Ahmet Çağkan İnkaya, Fatma Ni̇sa Balli, Emre Kara, Sali̇h Kutay Demi̇rkan, Serhat Ünal
A Retrospective Study: Can Dual Art Mitigate The Risk Of Potential Drug-Drug Interactions Among Plwh Under Stable Art?, Ahmet Çağkan İnkaya, Fatma Ni̇sa Balli, Emre Kara, Sali̇h Kutay Demi̇rkan, Serhat Ünal
Turkish Journal of Medical Sciences
Background/aim: People living with human immunodeficiency virus (PLWH) are getting older. Age-related comorbidities in PLWH result in polypharmacy and increase the risk for potential drug-drug interactions (pDDIs). This study aimed to evaluate how the rate of pDDIs would change if the treatment of patients receiving different combined antiretroviral therapies (ARTs) were theoretically changed with dolutegravir/lamivudine (DTG+3TC) or cabotegravir/rilpivirine (CAB+RPV). Materials and methods: This study was conducted at the infectious disease outpatient clinic of a university hospital as a follow-up of a previous study. The data of PLWH receiving at least 1 comedication other than antiretrovirals (ARVs) were retrospectively reviewed and …
Determining The Protective Effect Of A Boron Adjuvanted Vaccine With An Experimental Infection Model In Mice, Zafer Sayin, Ali̇ Uslu, Özgür Özdemi̇r, Abdullah Başoğlu, Asli Balevi̇, Uçkun Sai̇t Uçan, Zeki̇ Aras, Osman Ergani̇ş
Determining The Protective Effect Of A Boron Adjuvanted Vaccine With An Experimental Infection Model In Mice, Zafer Sayin, Ali̇ Uslu, Özgür Özdemi̇r, Abdullah Başoğlu, Asli Balevi̇, Uçkun Sai̇t Uçan, Zeki̇ Aras, Osman Ergani̇ş
Turkish Journal of Veterinary & Animal Sciences
Boron is a required trace element for plants, humans, and animals and it has significant influence over biological functions and the immune system. Vaccines have aided humans in the control of many contagious diseases around the world. The success of global immunization campaigns may be possible with the development of effective and low-cost vaccines and adjuvants. For this reason, the present study aimed to determine the adjuvant activity of easily accessible boron compounds. In this study, six different vaccines were prepared, including inactive Staphylococcus aureus bacteria, boric acid, aluminum hydroxide, montanide ISA 50, and ISA 206, ISA 50 + boric …
Effect Of Exogenous Melatonin On Metabolic Profile And Reproductive Performance In Undernourished Suckling Merino Ewes In The Early Postpartum Period, Bariş Güner, Buse Öztürk, Aslihan Ayalp, İhsan Kisadere, Nevzat Saat, Muhi̇tti̇n Zengi̇n, Recai̇ Kulaksiz, Şükrü Meti̇n Pancarci
Effect Of Exogenous Melatonin On Metabolic Profile And Reproductive Performance In Undernourished Suckling Merino Ewes In The Early Postpartum Period, Bariş Güner, Buse Öztürk, Aslihan Ayalp, İhsan Kisadere, Nevzat Saat, Muhi̇tti̇n Zengi̇n, Recai̇ Kulaksiz, Şükrü Meti̇n Pancarci
Turkish Journal of Veterinary & Animal Sciences
This study aimed to determine whether serum metabolite and hormones of ewes with low body condition scores subjected to the melatonin plus progesterone-based protocol (MPE) would be similar to a single progesterone-based protocol (PE) and whether melatonin ear implant supplementation could increase pregnancy rate. Ninety suckled Merino ewes with singleton lamb were equally allocated in two experimental groups (MPE, PE) and a control group (CON) on days 53 ± 3 (D0) postpartum. Ewes in MPE group were subjected to exogenous melatonin plus progesterone-based protocol [Melatonin (day 0) + P4 insertion (day 35) + 500 IU eCG (day 42)]. Ewes in …
Radiographic Pelvimetry In Scottish Fold Cats: Sex-Related Differences, Osman Yilmaz, Davut Koca, Talha Avcilar
Radiographic Pelvimetry In Scottish Fold Cats: Sex-Related Differences, Osman Yilmaz, Davut Koca, Talha Avcilar
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to obtain osteometric measurements of the pelvis of Scottish Fold cats using X-ray images and reveal the biometric differences of these measurement values in terms of sexual dimorphism. Radiographic images of the pelvis in the laterolateral and ventrodorsal direction were used in male and female Scottish Fold cats aged 2-4 years with dystocia and eutocia. The measurements of 18 osteometric parameters and 36 parameters, such as the height/width ratio of the cat pelvis, were taken, and statistical analysis of the measurements was initiated. When the pelvimetric data were examined, it was observed that all of …
Comparison Of Carcass Characteristics, Meat Quality, And Fatty Acid Composition In Slowand Fast-Growing Broilers At Different Slaughter Weights, Büşra Yaranoğlu, Hi̇lal Çapar Akyüz, Esi̇n Ebru Onbaşilar
Comparison Of Carcass Characteristics, Meat Quality, And Fatty Acid Composition In Slowand Fast-Growing Broilers At Different Slaughter Weights, Büşra Yaranoğlu, Hi̇lal Çapar Akyüz, Esi̇n Ebru Onbaşilar
Turkish Journal of Veterinary & Animal Sciences
This study aimed to compare the slaughter, meat quality characteristics, and fatty acid composition of fast-growing (FAG) and slow-growing (SWG) broilers at different slaughter weights. In the experiments, a total of 90 carcasses were used: 45 SWG (Hubbard-Isa Red JA) and 45 FAG broilers (Ross 308) with 15 carcasses from each slaughter weight group (1500 ± 50 g, 2000 ± 50 g, 2500 ± 50 g). Hot carcass yield and cold carcass yield detected in the FAG broilers were higher than in SGW broilers (p < 0.001). As the weight of slaughter increased, hot carcass and cold carcass yield increased (p < 0.001). The breast percentage was significantly lower in the SWG broilers compared to the FAG broilers (p < 0.001). In contrast, thigh, wing, and abdominal fat percentages were higher in the SWG broilers (p < 0.001). The breast percentage increased as the slaughter weight increased (p < 0.001). SWG broilers had significantly lower pH, except for the pH 24 of the thigh meat (p < 0.01). The L*, a*, and b* values of the SWG broilers were lower than the FAG broilers (p < 0.01). In terms of a* values determined initially and at the 24th h in the breast and thigh meat, the 1500 g slaughter weight group had by far the highest value (p < 0.01). SWG broilers had significantly lower values in terms of cooking loss, water-holding capacity, and drip loss (p < 0.001). C18:2ω6 was detected at higher amounts in the FAG broilers (p < 0.05). The FAG broilers had higher PUFA, desired fatty acids, PUFA/SFA, and thrombogenic index values (p < 0.05). The results show that FAG broilers can meet the strong worldwide demand for meat quantity and quality. Slaughter weight changes only affected the quantity of the meat.
Evaluation Of The Effects Of Ghrelin And Metformin On Sperm Parameters, Testosterone Hormones, And Immunohistochemical And Immunofluorescent Markers In An Experimental Diabetes Model, Saadet Belhan, Zübeyi̇r Huyut, Serkan Yildirim, Özlem Ergül Erkeç, Uğur Özdek
Evaluation Of The Effects Of Ghrelin And Metformin On Sperm Parameters, Testosterone Hormones, And Immunohistochemical And Immunofluorescent Markers In An Experimental Diabetes Model, Saadet Belhan, Zübeyi̇r Huyut, Serkan Yildirim, Özlem Ergül Erkeç, Uğur Özdek
Turkish Journal of Veterinary & Animal Sciences
Testicular dysfunction, a severe secondary complication of diabetes, negatively affects reproductive health. Ghrelin is a peptide that plays a role in many metabolic events, such as stimulating growth hormones and regulating appetite, blood pressure, and reproduction. Metformin has antiinflammatory and antioxidant properties and is widely used to treat type 2 diabetes. Therefore, in this study, to investigate the effects of ghrelin and metformin on testicular function in experimental diabetic rats given streptozotocin, placed on a high-fat diet, and that had their sperm parameters evaluated, testosterone hormone, caspase 3 and iNOS expression, and histopathological examinations were performed. In total, 38 Wistar …
Preantral Follicle Morphometry And Ultrastructure Of Antral Follicles In Anatolian Water Buffalo, Duygu Baki̇ Acar, Muhammed Kürşad Bi̇rdane, Çi̇ğdem Tokyol, Nermi̇n Nüket Göçmen Karabeki̇r, Hati̇ce Mürvet Hayran, Erhan Özenç, Fatma Aktepe, Ebubeki̇r Yazici, İlknur Pi̇r Yağci, Mehmet Uçar
Preantral Follicle Morphometry And Ultrastructure Of Antral Follicles In Anatolian Water Buffalo, Duygu Baki̇ Acar, Muhammed Kürşad Bi̇rdane, Çi̇ğdem Tokyol, Nermi̇n Nüket Göçmen Karabeki̇r, Hati̇ce Mürvet Hayran, Erhan Özenç, Fatma Aktepe, Ebubeki̇r Yazici, İlknur Pi̇r Yağci, Mehmet Uçar
Turkish Journal of Veterinary & Animal Sciences
This study aimed to evaluate quantitative and morphometric analyses of preantral follicles and the ultrastructural characteristics of antral follicles in different oestrous cycle stages in Anatolian water buffaloes. Twenty-four ovaries collected from twelve slaughtered Anatolian water buffaloes were classified macroscopically as luteal or follicular stages. The ovaries were prepared for histological examination (Hematoxylin-eosin staining), and primordial, primary, and secondary follicle numbers were calculated, and the diameters of oocytes, follicles, and nuclei were measured under a light microscope with a micrometre. The theca and granulosa cells of antral follicles were observed under a transmission electron microscope. The mean number of preantral …
The Effect Of Using Different Litter Materials In Broiler Rearing On Performance, Carcass Yield, Antioxidant Status, Some Litter Parameters, And Coccidiosis Oocysts, Gökhan Şen, Mehmet Naci̇ Oktay, Şevket Evci̇, Sami̇ Gökpinar, Ali̇ Şenol
The Effect Of Using Different Litter Materials In Broiler Rearing On Performance, Carcass Yield, Antioxidant Status, Some Litter Parameters, And Coccidiosis Oocysts, Gökhan Şen, Mehmet Naci̇ Oktay, Şevket Evci̇, Sami̇ Gökpinar, Ali̇ Şenol
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to determine the effects of various mixtures of different litter materials containing wood shaving and barley straw on body weight gain, feed consumption, feed efficiency, carcass yield, antioxidant state, litter quality, and coccidio oocysts in broilers rearing. For this purpose, a total of 120, 0-day-old Ross 308 broilers were assigned to 3 groups with 4 replicates. Wood shaving, barley straw, and wood shaving + barley straw group had 10 chicks in each replicate, a total of 40 chicks in each group. When the overall period of the study was examined, it was determined that …
Immunoreactivity Of Infiltrating Macrophages During Gastric Ulcer Healing In Rats, Erkmen Tuğrul Epi̇kmen, Emrah İpek, Recai̇ Tunca
Immunoreactivity Of Infiltrating Macrophages During Gastric Ulcer Healing In Rats, Erkmen Tuğrul Epi̇kmen, Emrah İpek, Recai̇ Tunca
Turkish Journal of Veterinary & Animal Sciences
This study investigated a timeline of changes in the immunoreactivity of infiltrating macrophages during gastric ulcer healing. To this end, gastric tissue samples were obtained from an acetic acid-induced gastric ulcer model in rats on the 1st, 3rd, 7th, and 14th days of ulcer induction. Ulcerated gastric tissues were subjected to histologic and immunohistochemical evaluations for macrophage subtypes. The number of Iba-1+ macrophages in the gastric ulcer area significantly increased on day 3, reaching a maximum number on day 7, followed by a decrease on day 14. No Gal-3+ macrophages were seen in the gastric ulcer area until day 14. …
In Vitro Determination Of The Anthelmintic Potential Of Arum Rupicola Boiss Var. Rupicola, Tuğrul Atalay, Kader Yildiz
In Vitro Determination Of The Anthelmintic Potential Of Arum Rupicola Boiss Var. Rupicola, Tuğrul Atalay, Kader Yildiz
Turkish Journal of Veterinary & Animal Sciences
Arum rupicola Boiss var. rupicola is a preferred ingredient in traditional medicine in various countries, including Türkiye. The current study aims to establish the antiparasitic effect of A. rupicola Boiss var. rupicola on the eggs and larvae of T. canis in vitro. An ovicidal effect was not detected in the plant extracts, and embryogenesis in the T. canis eggs was not affected by the leaves' ethanolic extract and the distilled water extract of the rhizome during the incubation periods (6, 12, and 24 h). The larvicidal activity was observed in both extracts on the T. canis larvae after hatching. All …
Is The Pediatric Eosinophilic Esophagitis Symptom Score V2.0 Reliable For Telemedicine?, Si̇nem Polat Terece, Di̇lek Yapar, Hacer İlbi̇lge Ertoy Karagöl, Gi̇zem Köken, Demet Teker Düztaş, Ödül Eğri̇taş, Si̇nan Sari, Buket Dalgiç, Arzu Bakirtaş
Is The Pediatric Eosinophilic Esophagitis Symptom Score V2.0 Reliable For Telemedicine?, Si̇nem Polat Terece, Di̇lek Yapar, Hacer İlbi̇lge Ertoy Karagöl, Gi̇zem Köken, Demet Teker Düztaş, Ödül Eğri̇taş, Si̇nan Sari, Buket Dalgiç, Arzu Bakirtaş
Turkish Journal of Medical Sciences
Background/aim: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Telemedicine is a healthcare technology used when a patient is separated by distance. The reliability of the Pediatric Eosinophilic Esophagitis Symptom Score, version 2.0 (PEESS v2.0) for telemedicine applications, has not been studied yet. Therefore, we aimed to evaluate the reliability of PEESS v2.0 for telemedicine. Materials and methods: We sent a telesurvey using questionnaires via electronic telecommunication as the telemedicine method. Children with EoE and their parents were asked to complete PEESS v2.0 with the telesurvey method (unsynchronized with the physician) and attend in-person visits one week apart. Intraclass correlation …
The Importance Of Skin Prick Test In Differentiating Cat Sensitivities And Allergies In Children, Mehmet Şi̇ri̇n Kaya, Özge Atay, İdi̇l Akay Haci, İlke Taşkirdi, Seli̇me Özen Bölük, Fi̇gen Çelebi̇ Çeli̇k, Özgen Soyöz, Canan Şule Ünsal Karkiner, Demet Can
The Importance Of Skin Prick Test In Differentiating Cat Sensitivities And Allergies In Children, Mehmet Şi̇ri̇n Kaya, Özge Atay, İdi̇l Akay Haci, İlke Taşkirdi, Seli̇me Özen Bölük, Fi̇gen Çelebi̇ Çeli̇k, Özgen Soyöz, Canan Şule Ünsal Karkiner, Demet Can
Turkish Journal of Medical Sciences
Background/aim: The incidence of cat allergies in children has increased over the years. Children with cat allergies have mostly reported respiratory symptoms. The skin prick test (SPT) is the most preferred method to demonstrate sensitization to allergens. However, not all children who develop cat sensitization due to environmental exposure become allergic to cats. In our study, we aimed to determine the frequency of sensitization to cat and cat allergy, cat-related symptoms, and the cut-off value for the SPT that may indicate cat allergy. Materials and methods: Patients aged 2-18 years, who applied to the Health Sciences University İzmir Dr Behçet …
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
Turkish Journal of Medical Sciences
Background/aim: Colorectal cancer (CRC) is one of the most common cancers worldwide. Many factors such as stress, lifestyle, and dietary habits are known to play a role in the initiation and progression of the disease. Herbal therapeutic agents including curcumin can hold a great potential against cancer treatment; however, their efficacy on CRC is still under investigation. Herein, we evaluated the anticancer mechanism of curcumin on four different CRC cell lines. Materials and methods: Cells were treated with curcumin for 24, 48 and 72 h, and IC50 doses for each cell line were calculated. Mechanistic studies were conducted with the …
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Turkish Journal of Medical Sciences
Background/aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Thymoquinone (TQ) has broad biological functions, including antiinflammatory, antioxidant, neuroprotective properties. Memantine (MEM) is indicated for the symptomatic treatment of moderate to severe AD. We aimed to evaluate the effect of TQ alone or in combination with MEM on memory and hippocampal morphology in an STZ-induced rat AD model. Materials and methods: Thirty male rats were included in this study. The AD model was created by giving ICV STZ. The rats were divided into 5 groups (n = 6 each). Group 1 (control group): The rats received only ICV-STZ 3 mg/kg …
Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek
Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate thymoquinone (TQ), and melatonin's radioprotective effects on liver, parotid gland, brain, and testis of rats which were exposed to total body irradiation (IR). Materials and methods: Thirty adult Wistar rats were randomly divided into four groups that are Group 1 (control group): total body IR only, Group 2: IR-Melatonin (10 mg/kg), Group 3: IR-TQ (10 mg/kg), and Group 4 (sham group): nothing. Total body IR dose was 6 Gy. Tissue samples were taken 90 min after IR. The measurements of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were performed in all groups. …
Melanocytic Tumors With Spitzoid Morphology: Correlation Of Clinicopathologic Features And Fish Analysis, Deni̇z Ünlüer Kapişkay, Övgü Aydin Ülgen, Ümi̇t İnce, Cüyan Demi̇rkesen
Melanocytic Tumors With Spitzoid Morphology: Correlation Of Clinicopathologic Features And Fish Analysis, Deni̇z Ünlüer Kapişkay, Övgü Aydin Ülgen, Ümi̇t İnce, Cüyan Demi̇rkesen
Turkish Journal of Medical Sciences
Background/aim: A subset of melanocytic tumors with spitzoid morphology may lead to potential inaccurate diagnosis and lack of assessment of malignancy potential. In this study, we aimed to evaluate melanocytic tumors with spitzoid morphology using conventional melanoma FISH (RREB-1, CCND1, MYB and CEP6) and 9p21 FISH (CDKN2A) probes and compare the probe results with clinical and histopathological features. Materials and methods: This study is a multicentric retrospective study including three centers, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, Department of Pathology, Acıbadem University, School of Medicine, Department of Pathology and ETA Pathology Laboratory. The pathology reports in archives of these three …
Evaluation Of Local And Systemic Side Effects Of Turkovac Vaccine In Adults, Bülent Nuri̇ Kalayci, Doğu Karahan
Evaluation Of Local And Systemic Side Effects Of Turkovac Vaccine In Adults, Bülent Nuri̇ Kalayci, Doğu Karahan
Turkish Journal of Medical Sciences
Background/aim: COVID-19 is a respiratory disease that caused a pandemic after reportedly emerging from Wuhan, China, in December 2019. Different types of COVID-19 vaccines such as viral vectors, mRNA, and inactivated vaccines have been produced since the beginning of the pandemic. Turkovac is an inactive COVID-19 vaccine developed and produced in Türkiye. We conducted our study to investigate the local and systemic side effects of the Turkovac vaccine. Materials and methods: A cross-sectional survey-based study was conducted to collect data on the postvaccine side effects in people aged over 18 who were vaccinated with Turkovac, between March and June 2022, …
Zero Ischemia Robotic Partial Nephrectomy: Oncological And Functional Outcomes Of A Multicenter Study, Kemal Ener, Abdullah Erdem Canda, Murat Bi̇nbay, Mevlana Derya Balbay, Ali̇ Fuat Atmaca
Zero Ischemia Robotic Partial Nephrectomy: Oncological And Functional Outcomes Of A Multicenter Study, Kemal Ener, Abdullah Erdem Canda, Murat Bi̇nbay, Mevlana Derya Balbay, Ali̇ Fuat Atmaca
Turkish Journal of Medical Sciences
Background/aim: The functional and oncological outcomes of zero ischemia robotic partial nephrectomy (RPN) procedures were evaluated. Materials and methods: A total of 56 patients underwent zero ischemia RPN transperitoneally, and their data were collected prospectively. Radius, exo/endophytic, nearness, anterior/posterior, location (R.E.N.A.L.) nephrometry, and PADUA scores were calculated. Patient and tumor characteristics were evaluated. Intra- and perioperative (0-30 days) complications were evaluated by Clavien classification. The change in serum creatinine, and estimated glomerular filtration rates (eGFR) were evaluated during preoperative, immediate postoperative periods, and at postoperative 6th months. Results: The mean age of the patients was 52.2 ± 8.1 (27-75) years. …
Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar
Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar
Turkish Journal of Medical Sciences
Background/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods: This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: Of 134 …
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim:The aim of our study was to evaluate the long-term impacts of Kawasaki disease on our patients regarding coronary involvement demographic characteristics, treatment regimens, and clinical course. Materials and methods: Our study included 104 patients diagnosed and hospitalized with Kawasaki disease in our center, from January 2004 to January 2019. In our study, patients were divided into three groups according to coronary artery involvement. Patients in group 1 had no echocardiographic findings, while the ones in group 2 had coronary artery dilatation and ones in group 3 had coronary artery aneurysm (CAA). Results:Among 104 patients, the median age was 9.15 …
Emergency Ultrasound Of Respiratory Muscles: A Promising Tool For Determining The Outcomes Of Copd Exacerbations, Di̇nçer Yegi̇n, Alten Oskay, Tülay Oskay, Selcan Enver Di̇nç, Hande Şenol, Mert Özen, Vefa Çakmak, Murat Seyi̇t, Atakan Yilmaz, İbrahi̇m Türkçüer
Emergency Ultrasound Of Respiratory Muscles: A Promising Tool For Determining The Outcomes Of Copd Exacerbations, Di̇nçer Yegi̇n, Alten Oskay, Tülay Oskay, Selcan Enver Di̇nç, Hande Şenol, Mert Özen, Vefa Çakmak, Murat Seyi̇t, Atakan Yilmaz, İbrahi̇m Türkçüer
Turkish Journal of Medical Sciences
Background/aim: The respiratory muscles of patients with chronic obstructive pulmonary disease (COPD) exhibit structural and functional changes that can be evaluated and monitored by ultrasonography. Materials and methods: This single-center, prospective study was conducted in the emergency department (ED) of a tertiary care hospital over an eight-month period (September 2020-May 2021). Diaphragmatic excursions, end-expiratory thickness, and thickening fractions, as well as right and left intercostal muscle thicknesses, of all adult subjects manifesting COPD exacerbation, were assessed. The data were analyzed regarding ward/intensive care unit (ICU) hospitalization or discharge from the ED, mortality, and readmission within 15 days. Results: Sixty-three subjects …
Initial Alpha-1 Antitrypsin Screening In Turkish Patients With Chronic Obstructive Pulmonary Disease, Seda Tural Önür
Initial Alpha-1 Antitrypsin Screening In Turkish Patients With Chronic Obstructive Pulmonary Disease, Seda Tural Önür
Turkish Journal of Medical Sciences
Background/aim: Alpha-1 antitrypsin (AAT) deficiency is associated with several types of pathology, and the reported effects of mutations in the ATT-encoding gene vary worldwide. No Turkish study has yet appeared. We thus explored the AAT status of Turkish patients with chronic obstructive pulmonary disease (COPD). Materials and methods: This prospective cross-sectional study included outpatients and inpatients treated from June 2021 to June 2022. Serum AAT levels were checked, and dry blood samples were subjected to genetic analysis. Results: Genetic mutations were found in 21 (3.52%) of 596 patients with prior and new COPD diagnoses treated in our pneumonology outpatient department. …
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX) is a folic acid antagonist that is widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune and inflammatory diseases. The most important concerns with MTX are its poor solubility and high toxicity, particularly in liver cells. To enhance its solubility and to minimize its toxicity, we encapsulated MTX in niosomes and investigated its hepatotoxicity mechanisms using genetic biomarkers. Materials and methods: Niosomes were successfully prepared using a modified thin film method, and the prepared monodisperse smallsized formulation was subsequently characterized. In vitro cytotoxicity studies were performed both in hepatocarcinoma (HEP3G) and healthy liver (AML12) cell lines. …
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) patients may be protected against cancer because of increased immune surveillance. However, aberrant T/B cell functioning in MS may increase the risk of cancer. We aimed to compare the frequency of cancer among patients with MS with an appropriate control group matched by the variables such as age, gender, tobacco smoking history, body mass index (BMI), and family history of cancer. Materials and methods: The MS patients who were registered and followed up at the MS Center in Hacettepe University Hospitals and appropriately matched with controls were included. A self-administered questionnaire with links to the online …
An Evaluation Of Canine Inguinal Hernias Containing The Uterus: Clinical Experience Of Four Cases (2017-2022) And Literature Review, Fi̇rdevs Bi̇nli̇, Fati̇h Büyükbudak, İpek İnan, Volkan Ferahoğlu, Anil Gürkan Aksu, Murat Findik, Serhan Serhat Ay
An Evaluation Of Canine Inguinal Hernias Containing The Uterus: Clinical Experience Of Four Cases (2017-2022) And Literature Review, Fi̇rdevs Bi̇nli̇, Fati̇h Büyükbudak, İpek İnan, Volkan Ferahoğlu, Anil Gürkan Aksu, Murat Findik, Serhan Serhat Ay
Turkish Journal of Veterinary & Animal Sciences
The aim of this study is to identify and summarize the evidence and risk factors of canine inguinal hernia containing the uterus (Inguinal Hysterocele; IH) etiology by presenting our clinical experience with a literature review. A total of 18 canine IH cases were evaluated in the study. Of these, four have not yet been published anywhere, two have been published before, and 12 were obtained through a literature review. According to the findings, 81.3% of the cases were small/medium races, 83.3% were ≥5 years old, and 72.7% were multiparous. Totally 83.3% of the cases were chronic and 72.2% of the …