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Articles 5551 - 5580 of 8080
Full-Text Articles in Medicine and Health Sciences
Parental Knowledge And Practices Regarding Febrile Convulsions In Turkish Children, Ertan Kayseri̇li̇, Aycan Ünalp, Hurşi̇t Apa, Suna Asi̇lsoy, Murat Hizarcioğlu, Pami̇r Gülez, Hasan Agin
Parental Knowledge And Practices Regarding Febrile Convulsions In Turkish Children, Ertan Kayseri̇li̇, Aycan Ünalp, Hurşi̇t Apa, Suna Asi̇lsoy, Murat Hizarcioğlu, Pami̇r Gülez, Hasan Agin
Turkish Journal of Medical Sciences
Aims: Families with children afflicted with febrile convulsions must be given adequate information regarding seizures and fever, and they need emotional support and first-aid demonstrations. In this study, we aimed to determine parental knowledge and practices regarding febrile convulsions in Turkish children. Materials and Methods: Questionnaires were given to 122 parents whose children were admitted to the emergency service of Behçet Uz Children´s Hospital between July 2006 and April 2007 with febrile convulsion episodes. Sixty-three parents whose children had a febrile convulsion for the first time (Group 1) and 59 parents whose children had a recurrent febrile convulsion (Group 2) …
Co-Existence Of Intrahepatic Bile Duct Adenoma And Colonic Adenocarcinoma, Gülen Akyol, Nüket Üzüm, Nusret Akyürek, Bülent Menteş
Co-Existence Of Intrahepatic Bile Duct Adenoma And Colonic Adenocarcinoma, Gülen Akyol, Nüket Üzüm, Nusret Akyürek, Bülent Menteş
Turkish Journal of Medical Sciences
Intrahepatic bile duct adenoma (BDA) is a rare benign tumor of the liver that is usually diagnosed by microscopic examination. Most cases are incidentally discovered during surgery or autopsy. Here, we report the co-existence of colonic adenocarcinoma and intrahepatic BDA mimicking metastasis in a 62-year-old man. The patient underwent metastasectomy because of the presence of colonic adenocarcinoma diagnosed at almost the same time. The diagnosis was benign in frozen sections intraoperatively and total colectomy was performed during the same operation. BDA should be included in the diseases to be differentiated from hepatic primary or metastatic tumors.
Ductal Carcinoma Of The Parotid Gland Coexisting With Pleomorphic Adenoma, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Tayyar Selçuk, Uğur Çakmak, Seli̇m Çelebi̇oğlu
Ductal Carcinoma Of The Parotid Gland Coexisting With Pleomorphic Adenoma, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Tayyar Selçuk, Uğur Çakmak, Seli̇m Çelebi̇oğlu
Turkish Journal of Medical Sciences
Benign tumors of the parotid gland such as pleomorphic adenoma present as a painless mass and pose no difficulty in diagnosis. It is very rare to find a benign mass coexisting with a malignant entity in the parotid gland. We present a case of pleomorphic adenoma coexisting with ductal carcinoma.
Acute Intoxication By Endosulfan: Any Role Of N-Acetylcysteine Therapy?, Ahmet Demi̇rcan, Eli̇f Çalidağ, Murat Özsaraç, Ayfer Keleş, Fi̇kret Bi̇ldi̇k
Acute Intoxication By Endosulfan: Any Role Of N-Acetylcysteine Therapy?, Ahmet Demi̇rcan, Eli̇f Çalidağ, Murat Özsaraç, Ayfer Keleş, Fi̇kret Bi̇ldi̇k
Turkish Journal of Medical Sciences
Reactive oxygen species may play a role in the mediation of acetaminophen (APAP) hepatotoxicity. N-acetylcysteine (NAC) is the standard therapy for treatment of the APAP overdose patient. The suspected mechanism of hepatic injury appears to be similar to that of APAP and the empiric use of NAC may be justified, especially in significant endosulfan poisoning. An 18-year-old male presented to the emergency department because of unconsciousness and seizure that developed after acute intentional ingestion of endosulfan. Severe diaphoresis was noted and he had a Glasgow Coma Score of 7 (E1M4V2). Within 8 hours of his arrival in the emergency department, …
Purtscher´S Retinopathy: An Unusual Association With A Complicated Mandibular Fracture, Tongabay Cumurcu, Hüseyi̇n Yardim, Mehmet Güven, Raşi̇t Kiliç, Ni̇lüfer Özkan
Purtscher´S Retinopathy: An Unusual Association With A Complicated Mandibular Fracture, Tongabay Cumurcu, Hüseyi̇n Yardim, Mehmet Güven, Raşi̇t Kiliç, Ni̇lüfer Özkan
Turkish Journal of Medical Sciences
We present a case of unilateral traumatic retinal angiopathy following a mandibular fracture. An 11-year-old child involved in a bicycle accident developed Purtscher´s retinopathy in the left eye with retinal hemorrhages, cotton wool spots, and optic disc swelling on funduscopy. The visual acuity in this eye was counting fingers at one meter.
Generalized Choreoathetosis In An Acquired Immune Deficiency Syndrome Patient With Cerebral Toxoplasmosis, İpek Mi̇di̇, Hari̇ka G. Çalişkan, Zafer Toktaş, Aydin Sav, Di̇lek İ. Günal
Generalized Choreoathetosis In An Acquired Immune Deficiency Syndrome Patient With Cerebral Toxoplasmosis, İpek Mi̇di̇, Hari̇ka G. Çalişkan, Zafer Toktaş, Aydin Sav, Di̇lek İ. Günal
Turkish Journal of Medical Sciences
Many hypokinetic and hyperkinetic movement disorders (e.g. parkinsonism, chorea, myoclonus, dystonia) are associated with acquired immune deficiency syndrome (AIDS) and may sometimes represent the initial manifestation of the illness. We described a 37-year-old human immunodeficiency virus (HIV)-infected patient with generalized choreoathetoid movements associated with AIDS. Cranial MRI revealed multiple cerebral and cerebellar abscesses. The diagnosis of toxoplasmosis was established by brain biopsy. Hemichorea and hemiballismus in AIDS patients are pathognomonic findings of cerebral toxoplasmosis. Generalized choreiform movement is a rare condition and related to the bilateral cerebral involvement in toxoplasma disease affecting the subcortical structures.
Biliary Pseudolithiasis In A Neonate: A New Complication Of Total Parenteral Nutrition, Nurdan Uras, Zeynep İleri̇soy Yakut, Alparslan Tonbul, Ahmet Karadağ, Cüneyt Tayman, Semra Kara, Mustafa Mansur Tatli
Biliary Pseudolithiasis In A Neonate: A New Complication Of Total Parenteral Nutrition, Nurdan Uras, Zeynep İleri̇soy Yakut, Alparslan Tonbul, Ahmet Karadağ, Cüneyt Tayman, Semra Kara, Mustafa Mansur Tatli
Turkish Journal of Medical Sciences
No abstract provided.
Highly Elevated Adenosine Deaminase Level In Brucellar Pleural Effusion, Mustafa Kasim Karahocagi̇l, Hayretti̇n Akdeni̇z, Azi̇z Dursun Kirikçi, Hasan Karsen, Bünyami̇n Sertoğullari
Highly Elevated Adenosine Deaminase Level In Brucellar Pleural Effusion, Mustafa Kasim Karahocagi̇l, Hayretti̇n Akdeni̇z, Azi̇z Dursun Kirikçi, Hasan Karsen, Bünyami̇n Sertoğullari
Turkish Journal of Medical Sciences
Pleural involvement is a rare presentation of brucellosis. There are only a few case reports in the literature presenting with pleural involvement due to brucellosis. In this report, we present a case with exudative pleural fluid first considered as tuberculous pleurisy due to lymphocyte predominance and elevated level of pleural adenosine deaminase, but later diagnosed as brucella pleurisy with positive serologic and microbiologic test results. In conclusion, in the differential diagnosis of pleurisies, routine serologic and bacteriologic methods appear to be more important than pleural adenosine deaminase elevation, especially in regions endemic for both tuberculosis and brucellosis.
A Personal Ethics Responsibility Example: The Relationship Between Child Development And Drugs Taken By Pregnant Mother, Çağatay Üstün, Özge Özgürler
A Personal Ethics Responsibility Example: The Relationship Between Child Development And Drugs Taken By Pregnant Mother, Çağatay Üstün, Özge Özgürler
Turkish Journal of Medical Sciences
Personal responsibility is an important ethical concept. The pregnant mother should regard this concept as of prime importance. The pregnant mother should take some precautions in order to protect her own health and that of her baby in order to provide for its normal development. In this communication, we address the general effects of medications or drugs ingested by a pregnant mother on the baby. Thus, we target refinement of the personal ethic responsibility of the mothers.
Seminal Plasma Transforming Growth Factor-\Beta (Tgf-\Beta) And Epidermal Growth Factor (Egf) Levels In Patients With Varicocele, Üçler Kisa, M. Murad Başar, Mehmet Ferhat, Osman Çağlayan
Seminal Plasma Transforming Growth Factor-\Beta (Tgf-\Beta) And Epidermal Growth Factor (Egf) Levels In Patients With Varicocele, Üçler Kisa, M. Murad Başar, Mehmet Ferhat, Osman Çağlayan
Turkish Journal of Medical Sciences
Aims: The aim of this study was to analyze seminal plasma epidermal growth factor (EGF) and transforming growth factor-\beta (TGF-\beta) levels in infertile patients with varicocele and normal fertile cases, and to evaluate the relationships between seminal plasma EGF and TGF-\beta, seminal parameters and serum hormone levels. Materials and Methods: A total of 100 patients with varicocele were enrolled into the study. Semen analyses were performed after 2 and 5 days of sexual abstinence. These patients were divided into two groups based on the results of semen analysis as oligoasthenoteratozoospermia (Group 1) and normal semen analysis (Group 2). Additionally, 100 …
The Effects Of Intravenous Glutamine On Bacterial Translocation And Intestinal Morphology In Experimental Pancreatitis, Hüseyi̇n Berkem, Bülent C. Yüksel, Ruki̇ye Berkem, S. Yi̇ği̇t Yildiz, Kubi̇lay Gündoğdu, İ. Hakan Özel, Serdar Topaloğlu, Süleyman Hengi̇rmen
The Effects Of Intravenous Glutamine On Bacterial Translocation And Intestinal Morphology In Experimental Pancreatitis, Hüseyi̇n Berkem, Bülent C. Yüksel, Ruki̇ye Berkem, S. Yi̇ği̇t Yildiz, Kubi̇lay Gündoğdu, İ. Hakan Özel, Serdar Topaloğlu, Süleyman Hengi̇rmen
Turkish Journal of Medical Sciences
Aim: The aim of this study was to investigate the effects of intravenous glutamine administration on bacterial translocation and intestinal morphology in rats with induced acute pancreatitis. Materials and Methods: Forty-eight Wistar-Albino rats were divided into four groups (n = 12 for each group). Pancreatitis was induced with ligation of the main pancreatobiliary duct except in the sham group, in which only periportal dissection was performed. Rats in the sham and control groups were exposed to standard rat pellet. Total parenteral nutrition (TPN) was administered solely to the pancreatitis + TPN group and together with glutamine (Gln) to the pancreatitis …
Is Ghrelin A Natural Anti-Microbial Agent?, Süleyman Aydin, Hi̇kmet Geçki̇l, Nermi̇n Kiliç, Fazi̇let Erman, S. Sirri Kiliç, Özfer Yeşi̇lada
Is Ghrelin A Natural Anti-Microbial Agent?, Süleyman Aydin, Hi̇kmet Geçki̇l, Nermi̇n Kiliç, Fazi̇let Erman, S. Sirri Kiliç, Özfer Yeşi̇lada
Turkish Journal of Medical Sciences
No abstract provided.
Antioxidant Effect Of Melatonin In Systemic Circulation Of Rats After Unilateral Testicular Torsion, Fi̇kret Erdemi̇r, Beki̇r Suha Parlaktaş, Hüseyi̇n Özyurt, Özgür Boztepe, Ömer Atiş, Semsetti̇n Şahi̇n
Antioxidant Effect Of Melatonin In Systemic Circulation Of Rats After Unilateral Testicular Torsion, Fi̇kret Erdemi̇r, Beki̇r Suha Parlaktaş, Hüseyi̇n Özyurt, Özgür Boztepe, Ömer Atiş, Semsetti̇n Şahi̇n
Turkish Journal of Medical Sciences
Aim: To investigate the antioxidant effects of melatonin in the systemic circulation of rats after unilateral testicular torsion. Materials and Methods: After the approval of the study by the Local Ethical Committee, 30 male Wistar albino rats, 5.5-6 months old and weighing 250-300 g, were used in the study. The rats were randomly divided into three groups, each consisting of 10 rats. In group 1, the control group, the left testis was excised after sham operation. In group 2, the torsion group, torsion was created by rotating the left testis 720° in clockwise direction and maintained for 2 h. In …
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Turkish Journal of Medical Sciences
Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnancies. Materials and Methods: Placental samples were collected after delivery from normotensive pregnancies and preeclamptic patients (n = 20, each). Lipid peroxidation product malondialdehyde (MDA) and nitrite and nitrate levels, along with antioxidants such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) …
Resident Physicians In Turkey: Results Of A Survey Of 1069 Residents From 11 Provinces, Erhan Aysan, Gürol Köroğlu, Vi̇ldan Türkeli̇, Abdullah Özgönül, Ali̇ Özyaşar, Çağri Gülümser, Kemal Kiliç, Türker Ertürk, Özhan Özdemi̇r, Ahmet Hamdi̇ Alpaslan, Savaş Bayrak
Resident Physicians In Turkey: Results Of A Survey Of 1069 Residents From 11 Provinces, Erhan Aysan, Gürol Köroğlu, Vi̇ldan Türkeli̇, Abdullah Özgönül, Ali̇ Özyaşar, Çağri Gülümser, Kemal Kiliç, Türker Ertürk, Özhan Özdemi̇r, Ahmet Hamdi̇ Alpaslan, Savaş Bayrak
Turkish Journal of Medical Sciences
Aims: To determine the problems, expectations and objectives of resident physicians in Turkey and to provide a contribution to the development and amendment of the residency program. Background: Residency varies considerably in accordance with factors like teaching staff, the institution and government policies. If characteristics, problems, expectations and objectives of resident physicians are stated and known, development and amendment of residency programs will be both easier and faster. Materials and Methods: A 50-question survey was completed by a randomly selected 1069 resident physicians from 15 university and 12 teaching hospitals in 11 provinces (İstanbul-503, Ankara-116, İzmir-86, Erzurum-71, Sivas-60, Bolu-49, Bursa-49, …
Il-10 And Il-13 Production By Peripheral Blood Mononuclear Cells In Patients With Diabetes Mellitus, Ali̇ İnal, Uğur Muşabak, Göksal Keski̇n, Levent Özsari, Ali̇ Şengül, Mustafa Kutlu, Çağatay Öktenli̇, Zeki̇ Yeşi̇lova
Il-10 And Il-13 Production By Peripheral Blood Mononuclear Cells In Patients With Diabetes Mellitus, Ali̇ İnal, Uğur Muşabak, Göksal Keski̇n, Levent Özsari, Ali̇ Şengül, Mustafa Kutlu, Çağatay Öktenli̇, Zeki̇ Yeşi̇lova
Turkish Journal of Medical Sciences
Aim: It is generally accepted that proinflammatory cytokines secreted by mononuclear cells are responsible for pancreatic beta (B) cell destruction in animal models of autoimmune type-1 diabetes mellitus (DM). Several studies have shown that markers of inflammation and pro-inflammatory cytokines such as interleukin (IL)-10 and IL-13 associate with the metabolic syndrome, dyslipidemia, type-2 DM and type-1 DM. The aim of this study was to examine the in vitro production of IL-10 and IL-13 in cultures of peripheral lymphocytes obtained from patients with type-2 DM, type-1 DM and healthy controls. Materials and Methods: Twenty patients (10 females, 10 males) with type-2 …
Efficacy Of Clomipramine, Sertraline And Terazosin Treatments In Premature Ejaculation, Altuğ Tuncel, Yilmaz Aslan, M. Murad Başar, Ali̇ Atan
Efficacy Of Clomipramine, Sertraline And Terazosin Treatments In Premature Ejaculation, Altuğ Tuncel, Yilmaz Aslan, M. Murad Başar, Ali̇ Atan
Turkish Journal of Medical Sciences
Aim: To compare the efficacy of oral clomipramine, sertraline and terazosin to placebo in premature ejaculation. Materials and Methods: A total of 90 patients aged from 20 to 58 years were enrolled in this study. Patients were randomized into 4 groups. Group 1 (n: 22) took placebo and served as controls. Group 2 (n: 23) patients took 25 mg clomipramine HCl nightly; Group 3 (n: 20) 50 mg sertraline nightly; and Group 4 (n: 25) 5 mg terazosin nightly. The medications were used for two months. After 8 sexual attempts, the patients' clinical responses were assessed using the patient self-description …
The Effects Of Perioperative Low - Moderate Doses Of Dexmedetomidine Infusion On Hemodynamic And Neuroendocrine Parameters, Çeti̇n Kaymak, Hülya Başar, Nur Doğanci, Özgür Sert, Alpaslan Apan
The Effects Of Perioperative Low - Moderate Doses Of Dexmedetomidine Infusion On Hemodynamic And Neuroendocrine Parameters, Çeti̇n Kaymak, Hülya Başar, Nur Doğanci, Özgür Sert, Alpaslan Apan
Turkish Journal of Medical Sciences
Aim: The aim of this study was to determine the effects of low and moderate doses of dexmedetomidine infusions by evaluating hemodynamic and neuroendocrine responses in patients undergoing elective transurethral surgery. Materials and Methods: Fifty patients were randomly allocated to receive 0.45 (Group 1) or 0.6 (Group 2) µg kg^{-1} hr^{-1} dexmedetomidine infusion 10 minutes before induction of anesthesia. Heart rate, blood pressures, ETCO2 and peripheral oxygen saturation values and parameters of non-invasive cardiac output were monitored. Measurement times were baseline (I), after dexmedetomidine infusion (II), after thiopental induction (III), after intubation (IV) and at 10-minute intervals during desflurane anesthesia. …
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy With Delayed Diagnosis, Esra Tuğ, Efsun Şenocak
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy With Delayed Diagnosis, Esra Tuğ, Efsun Şenocak
Turkish Journal of Medical Sciences
Spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA) is a rare autosomal recessive hereditary skeletal disease, and mutations in WISP3 are responsible for its onset. WISP3 is essential for maintaining cartilage integrity mainly by regulating the expression of collagen II, and mutations of WISP3 linked to SEDT-PA can compromise this function and lead to cartilage loss, which is frequently misdiagnosed as juvenile idiopathic arthritis. It is characterized by arthralgia, joint contractures, bony swelling of metacarpophalangeal and interphalangeal joints and platyspondyly. Clinical and laboratory signs of joint inflammation such as synovitis, a high erythrocyte sedimentation rate and an elevated C-reactive protein level …
Rare Complication Of Meckel´S Diverticulum: Loop Formation Of Diverticulum, Oğuzhan Karatepe, Cem Dural, Candaş Erçeti̇n, Gamze Çitlak, Artur Salmaslioğlu, Osman Bi̇lgi̇n Gülçi̇çek, Servet Karahan
Rare Complication Of Meckel´S Diverticulum: Loop Formation Of Diverticulum, Oğuzhan Karatepe, Cem Dural, Candaş Erçeti̇n, Gamze Çitlak, Artur Salmaslioğlu, Osman Bi̇lgi̇n Gülçi̇çek, Servet Karahan
Turkish Journal of Medical Sciences
Meckel's diverticulum is the most prevalent congenital anomaly of the gastrointestinal tract, and is reported to occur in 1%-3% of the general population and autopsy series. The total lifetime rate of complications is widely accepted at 4%. Intestinal obstruction is the most common complication in adult patients. We present the diagnosis and management of our patient with intestinal obstruction due to loop formations of a Meckel's diverticulum.
Adhesion Of Beta1 Integrin To Fibronectin Regulates Cam-Dr Phenotype Via P21^{Waf1/Cip1} In Hl60 Acute Myeloid Leukemia (Aml) Cells, Hande Canpinar, Güneş Esendağli, Emi̇n Kansu, Aysen Günel Özcan, Di̇cle Güç
Adhesion Of Beta1 Integrin To Fibronectin Regulates Cam-Dr Phenotype Via P21^{Waf1/Cip1} In Hl60 Acute Myeloid Leukemia (Aml) Cells, Hande Canpinar, Güneş Esendağli, Emi̇n Kansu, Aysen Günel Özcan, Di̇cle Güç
Turkish Journal of Medical Sciences
Aims: Drug resistance is a major obstacle for a successful cancer therapy. Cell adhesion mediated drug resistance (CAM-DR) is a novel type of drug resistance and generated via interaction of cancer cells with the microenvironment. In this study, CAM-DR phenotype was analyzed in HL60 acute myeloid leukemia (AML) cells. Materials and Methods: Fibronectin (FN) adherence of HL60 cells was tested by a colorimetric adhesion assay. Flow cytometry analyses were performed to evaluate doxorubicin-induced apoptosis and to determine cell cycle status. Proliferation rate was evaluated by [^3H]-thymidine incorporation assay. Western blot and RT-PCR were used for analysis of the factors involved …
Scalpel Versus Electrocautery Dissections: The Effect On Wound Complications And Pro-Inflammatory Cytokine Levels In Wound Fluid, Mehmet Özdoğan, Keri̇m Bora Yilmaz, Ci̇hangi̇r Özaslan, Ahmet Gürer, Özlem Gülbahar, Eren Ersoy
Scalpel Versus Electrocautery Dissections: The Effect On Wound Complications And Pro-Inflammatory Cytokine Levels In Wound Fluid, Mehmet Özdoğan, Keri̇m Bora Yilmaz, Ci̇hangi̇r Özaslan, Ahmet Gürer, Özlem Gülbahar, Eren Ersoy
Turkish Journal of Medical Sciences
Aim: Electrocautery has been postulated as a risk factor for wound complications. This study was conducted to evaluate the effects of electrocautery and scalpel dissections on wound complications and local cytokine levels. Materials and Methods: Patients undergoing modified radical mastectomy were assigned to flap dissection with either electrocautery (n = 18) or scalpel (n = 20). Blood loss, drain volume and duration, seroma formation and wound complications were recorded. Tumor necrosis factor-alpha (TNF-\alpha) and interleukin (IL)-6 levels were measured in drain fluids at postoperative 24 hours. Results: The electrocautery group had significantly reduced blood loss and total drain volume, but …
Biological Variation And Reference Change Values Of Tsh, Free T3, And Free T4 Levels In Serum Of Healthy Turkish Individuals, Gönül Erden, Ayşe Özden Barazi̇, Günay Tezcan, Meti̇n Yildirimkaya
Biological Variation And Reference Change Values Of Tsh, Free T3, And Free T4 Levels In Serum Of Healthy Turkish Individuals, Gönül Erden, Ayşe Özden Barazi̇, Günay Tezcan, Meti̇n Yildirimkaya
Turkish Journal of Medical Sciences
Aim: Thyrotropin (TSH), thyroxine (T4) and triiodothyronine (T3) levels in serum are important for diagnosis of thyroid dysfunction. Thyroid function tests have considerable biological variations. Evaluation of the components of biological variation is essential to assess the usefulness of reference values and to evaluate significance of changes in serial results from an individual. Published estimates may show disagreement about the values of biological variations. Not many studies exist at present that evaluate the reference change values (RCV) of these parameters. The aim of this study was to determine the biological variations of TSH, free T3, and free T4 and to …
Rapid And Simultaneous Determination Of Acetylsalicylic Acid, Paracetamol, And Their Degradation And Toxic Impurity Products By Hplc In Pharmaceutical Dosage Forms, Cemal Akay, İsmai̇l Tuncer Deği̇m, Ahmet Sayal, Ahmet Aydin, Yalçin Özkan, Hüsametti̇n Gül
Rapid And Simultaneous Determination Of Acetylsalicylic Acid, Paracetamol, And Their Degradation And Toxic Impurity Products By Hplc In Pharmaceutical Dosage Forms, Cemal Akay, İsmai̇l Tuncer Deği̇m, Ahmet Sayal, Ahmet Aydin, Yalçin Özkan, Hüsametti̇n Gül
Turkish Journal of Medical Sciences
Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and degradation products during pharmaceutical development is necessary because of their potential toxicity. The aim of this study was to develop a rapid and simultaneous determination method for paracetamol and acetylsalicylic acid (ACA) and their degradation and toxic impurity products by high performance liquid chromatography (HPLC) in pharmaceutical dosage forms. Materials and Methods: A reverse phase (RP)-HPLC method for the simultaneous analysis of paracetamol, ACA, and ascorbic acid and their degradation and impurity products such as …
Review Of Syphilis Patient Records In İzmir State Venereal Diseases Clinic From 1994 To 2004, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Şebnem Şenol, Tansu Yamazhan, Levent Kidak, Deni̇z Gökengi̇n
Review Of Syphilis Patient Records In İzmir State Venereal Diseases Clinic From 1994 To 2004, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Şebnem Şenol, Tansu Yamazhan, Levent Kidak, Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Aim: The aim of this study was to evaluate patients attending a sexually transmitted infection (STI) outpatient clinic with a presumptive or definitive diagnosis of syphilis with regard to demographic characteristics, clinical findings, diagnostic criteria, treatment regimens and follow-up data over a 10-year period. Materials and Methods: The records of patients who had a presumptive/definitive diagnosis of syphilis [according to Centers for Disease Control (CDC) criteria] and who were referred to the İzmir State Venereal Diseases Outpatient Clinic or who were diagnosed in the clinic between 1994 and 2004 were reviewed retrospectively. Results: A total of 689 patients were included …
Neural Tube Defects And 19 Bp Deletion Within Intron-1 Of Dihydrofolate Reductase Gene, Nejat Akar, Ece Akar, Yonca Eği̇n, Gülhi̇s Deda, Saadet Arsan, Mesi̇ha Eki̇m
Neural Tube Defects And 19 Bp Deletion Within Intron-1 Of Dihydrofolate Reductase Gene, Nejat Akar, Ece Akar, Yonca Eği̇n, Gülhi̇s Deda, Saadet Arsan, Mesi̇ha Eki̇m
Turkish Journal of Medical Sciences
Aims: Dihydrofolate reductase (DHFR) is necessary for the reduction of the ingested folates before they are used in the body metabolism. Thus, the DHFR enzyme has an important role in folate supplementation and the DHFR gene is a strong candidate for a teratogenic locus for neural tube defects (NTDs). There is a 19 bp deletion within the first intron of the DHFR gene, which may have an effect on folate reduction. We thus studied this mutation in Turkish spina bifida patients and their mothers to determine whether there is an association with the occurrence of NTD. Materials and Methods: The …
Pten Expression In Primary Prostate Carcinoma In Turkish Patients, Di̇lek Ertoy Baydar, Haluk Özen, Osman Saraçbaşi, Erdem Karabulut
Pten Expression In Primary Prostate Carcinoma In Turkish Patients, Di̇lek Ertoy Baydar, Haluk Özen, Osman Saraçbaşi, Erdem Karabulut
Turkish Journal of Medical Sciences
Aim: Prostatic adenocarcinoma shows remarkable variability in the incidence and biological behavior between populations from different races and geographical regions of the world. PTEN has been reported as the most commonly mutated tumor suppressor gene in prostate cancer. Incidence of PTEN alterations occurring in prostatic carcinoma has not been studied previously in the Turkish population. Materials and Methods: We examined PTEN protein expression immunohistochemically and its significance in 69 primary prostate cancer patients from Turkey. Two tissue microarrays constructed by 0.6 mm cores from radical prostatectomy specimens were used. Clinical information for all patients was obtained from hospital records. Results: …
Oxidative Stress Of Radioiodine Treatment In Patients With Hyperthyroidism, Mustafa Yildiz, Ekrem Çi̇çek, Burçi̇n Aşkim Gümüş, Celal Çerçi̇, Süreyya Çerçi̇, Erol Eroğlu, Namik Deli̇baş
Oxidative Stress Of Radioiodine Treatment In Patients With Hyperthyroidism, Mustafa Yildiz, Ekrem Çi̇çek, Burçi̇n Aşkim Gümüş, Celal Çerçi̇, Süreyya Çerçi̇, Erol Eroğlu, Namik Deli̇baş
Turkish Journal of Medical Sciences
Aims: To investigate radiation-induced oxidative damage in erythrocytes after administration of radioiodine-131 (^{131}I) in patients with hyperthyroidism. Materials and Methods: Twenty patients with hyperthyroidism (11 F, 9 M) treated with ^{131}I were included into the study. Blood samples were taken from patients just before, 1 hour after and 3 hours after applying radioiodine. Malondialdehyde (MDA) and levels of antioxidant enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) were measured to evaluate the radiation-induced oxidative damage. Results: We found that enzyme activities of SOD, GPX and CAT were decreased 1 hour and 3 hours after radioiodine treatment …
Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Turkish Journal of Medical Sciences
Aims: Although vitamin B12 is currently used as a treatment option in patients with migraine, a possible cobalamin deficiency in those patients has not yet been investigated. In this study, we aimed to investigate cobalamin metabolism in patients with migraine. Materials and Methods: Fifty women having migraine without aura were matched with healthy controls (n=6) with the same age distribution. Fasting serum vitamin B12, folate, plasma total homocysteine (tHcy) and first morning urine methylmalonic acid (MMA) levels were determined in patient and control groups. Statistical differences in laboratory parameters between patient and control groups were analyzed by SPSS for Windows …
Serum Transforming Growth Factor-Β (Tgf-Β), Matrix Metalloproteinase-2 (Mmp-2), Matrix Metalloproteinase-9 (Mmp-9) And Tissue Inhibitors Of Metalloproteinase (Timp-1) Levels In Childhood Asthma, Fi̇gen Doğu, Ali̇şan Yildiran, Deni̇z Güloğlu, Funda Erol Çi̇pe, Mutlu Yüksek, Emel Babacan, Aydan İki̇nci̇oğullari
Serum Transforming Growth Factor-Β (Tgf-Β), Matrix Metalloproteinase-2 (Mmp-2), Matrix Metalloproteinase-9 (Mmp-9) And Tissue Inhibitors Of Metalloproteinase (Timp-1) Levels In Childhood Asthma, Fi̇gen Doğu, Ali̇şan Yildiran, Deni̇z Güloğlu, Funda Erol Çi̇pe, Mutlu Yüksek, Emel Babacan, Aydan İki̇nci̇oğullari
Turkish Journal of Medical Sciences
Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinases (MMPs) and their specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs) have been shown to be important in this process. In the present study, transforming growth factor (TGF)-\beta, MMP-2, MMP-9 and TIMP-1 levels in serum samples of children with stable asthma and healthy controls were evaluated to determine whether these levels show any difference between asthmatic and healthy children and whether or not these levels change with atopic status. Materials and …