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Articles 3631 - 3660 of 8080
Full-Text Articles in Medicine and Health Sciences
The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim
The First Ptpn11 Mutations In Hotspot Exons Reported In Moroccan Children With Noonan Syndrome And Comparison Of Mutation Rate To The Previous Studies, Ihssane El Bouchikhi, Imane Samri, Mohammed Iraqui Houssaini, Saaid Trhanint, Laila Bouguenouch, Hanane Sayel, Moustapha Hida, Samir Atmani, Karim Ouldim
Turkish Journal of Medical Sciences
Background/aim: Noonan syndrome is an autosomal dominant disorder with an incidence of 1/1000?2500. It results from protein-tyrosine phosphatase, nonreceptor type 11 (PTPN11) mutations in roughly 50% of cases. Mutational screening of PTPN11 has been carried out in different populations. Thus, the aim of this study was to screen, for the first time, PTPN11 mutations in a series of Moroccan Noonan syndrome patients. Materials and methods: We used bidirectional sequencing of exons 3 and 8, considered as PTPN11 mutation hot spots, and then compared the rate of mutational events of these exons between different populations using chi-square and Fisher?s exact tests. …
Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ
Hemodynamic Effects Of Atrial Natriuretic Peptide In Ischemia-Reperfusioninjury That Occurs After Exercise, Selma Arzu Vardar, Orki̇de Palabiyik, Ruhan Deni̇z Topuz, Eli̇f Ezgi̇ Gürel, Semra Çalişkan, Serap Topcu Özen, Necdet Süt, Çeti̇n Hakan Karadağ
Turkish Journal of Medical Sciences
Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 µM/L) were …
Urodynamic Disorders And Renal Scarring In Pediatric Patients With Nonmonosymptomatic Nocturnal Enuresis, Orkun Tolunay, Necla Buyan, Mustafa Özgür Tan, Hüsnü Oğuz Söylemezoğlu, Hati̇ce Ki̇bri̇ya Fi̇dan, Sevcan Azi̇me Bakkaloğlu Ezgü
Urodynamic Disorders And Renal Scarring In Pediatric Patients With Nonmonosymptomatic Nocturnal Enuresis, Orkun Tolunay, Necla Buyan, Mustafa Özgür Tan, Hüsnü Oğuz Söylemezoğlu, Hati̇ce Ki̇bri̇ya Fi̇dan, Sevcan Azi̇me Bakkaloğlu Ezgü
Turkish Journal of Medical Sciences
Background/aim: In nonmonosymptomatic nocturnal enuresis (NMNE), the incidence of organic abnormality and urodynamic disorder is more frequent than the general population. The aim of this study is to identify urodynamic disorders and renal scarring in children with NMNE. Materials and methods: This study evaluated the urodynamic disorders and renal scarring of a total of 30 patients who were diagnosed with NMNE. A video-urodynamic test and Tc-99m dimercaptosuccinic acid renal scintigraphy were applied. Results: Records of 605 patients who had been diagnosed with enuresis were analyzed, and 215 (33.5%) of them had been diagnosed with NMNE. Thirty patients older than 6 …
Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey
Evaluation Of Children Presenting To The Emergency Room After Electrical Injury, Aslihan Arasli Yilmaz, Ali̇ Osman Köksal, Osman Özdemi̇r, Mehtap Acar, Gülten Küçükkonyali, Yasemi̇n İnan, Si̇bel Çeli̇k, Mi̇ne Güveloğlu, Nesi̇be Andiran, Saci̇t Günbey
Turkish Journal of Medical Sciences
Background/aim: To evaluate children who presented to the Pediatric Emergency Department with electrical injury and to discuss the follow-up of these cases and potential precautions that can be taken. Materials and methods: A total of 36 patients presented to the Pediatric Emergency Department with electrical injury between May 2010 and May 2013, and these cases were investigated retrospectively. The patients? age and sex, location and form of exposure to electric current, seasonal distribution, length of hospital stay, musculoskeletal and cardiovascular system complications, renal damage, and treatments were recorded. Results: The majority of the patients were exposed to low-voltage electrical current …
Efficacy And Safety Of Intralesional Corticosteroid Application For Hemangiomas, Suna Emi̇r, Di̇lek Gürlek Gökçebay, Fatma Demi̇rel, Bahatti̇n Tunç
Efficacy And Safety Of Intralesional Corticosteroid Application For Hemangiomas, Suna Emi̇r, Di̇lek Gürlek Gökçebay, Fatma Demi̇rel, Bahatti̇n Tunç
Turkish Journal of Medical Sciences
Background/aim: There are different modalities for management of infantile hemangiomas (IHs). In this report, our aim is to evaluate whether intralesional corticosteroid treatment is associated with systemic side effects and whether this is an effective treatment modality for IH. Materials and methods: Six children treated with intralesional corticosteroids for problematic hemangiomas were included in the study. Clinical characteristics, response to treatment, weight, height, blood pressure, morning serum cortisol, and adrenocorticotropic hormone levels were recorded. Results: Each child received intralesional triamcinolone at a dose of 2 mg/kg for 2?5 injections at monthly intervals. Subjects were followed for 1 year. All patients …
Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin
Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin
Turkish Journal of Medical Sciences
Background/aim: Genetic polymorphism of CYP2D6 shows diverse pharmacokinetic and pharmacodynamic variation. Therefore, the present work was designed to study the variation in therapeutic responses to metoprolol (MP) in stage 1 hypertensive patients and also aims to verify the association of CYP2D6*4 polymorphism and response variation in an Indian population for the first time. Materials and methods: Clinically, a total of 119 hypertensive patients and 116 healthy individuals as controls were included. Patients were treated with MP extended release 25 mg tablets once daily for 2 weeks. Reduction in systolic blood pressure, diastolic blood pressure, and pulse rate were recorded before …
Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler
Premarital Screening Of 466 Mediterranean Women For Serum Ferritin,Vitamin B12, And Folate Concentrations, Aysun Karabulut, Ömer Tolga Güler, Hati̇ce Tuba Karahan, Sevgi̇ Özkan, Hasan Koyuncu, İbrahi̇m Demi̇rci̇ler
Turkish Journal of Medical Sciences
Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of
Retracted - Quantitative Study Of Epigenetic Signature In Head And Necksquamous Cell Carcinoma, Ayesha Umair, Bassel Tarakji, Alzoghaibi Ibrahim, Azzeghaibi Nasser, Alenzi Fq, Ayesha Shreen
Retracted - Quantitative Study Of Epigenetic Signature In Head And Necksquamous Cell Carcinoma, Ayesha Umair, Bassel Tarakji, Alzoghaibi Ibrahim, Azzeghaibi Nasser, Alenzi Fq, Ayesha Shreen
Turkish Journal of Medical Sciences
Background/aim: The aberrant upregulation of Forkhead box protein M1 (FOXM1) plays a fundamental role in cancer initiation by perturbing stem cell differentiation. This study aims to investigate the role of FOXM1 in epigenetic modification and gene expression of target genes in primary human oral keratinocytes, squamous cell carcinoma cell lines, and head and neck squamous cell carcinoma (HNSCC) tissue biopsies. Materials and methods: A genome-wide promoter methylation microarray was used to compare HNSCC cell line (n = 8), primary human oral keratinocytes (NOK; n = 8) transduced with FOXM1 and EGFP, and HNSCC tissue biopsies (n = 3). Seventeen Foxm1B-induced …
Two Gastrointestinal Conditions With Similar Symptoms And Endoscopicappearance: Irritable Bowel Syndrome And Microscopic Colitis, Zahi̇de Şi̇mşek, Nazi̇fe Candan Tunçer, Hakan Alagözlü, Fati̇h Karaahmet, Şahi̇n Çoban, Ayşe Dursun
Two Gastrointestinal Conditions With Similar Symptoms And Endoscopicappearance: Irritable Bowel Syndrome And Microscopic Colitis, Zahi̇de Şi̇mşek, Nazi̇fe Candan Tunçer, Hakan Alagözlü, Fati̇h Karaahmet, Şahi̇n Çoban, Ayşe Dursun
Turkish Journal of Medical Sciences
Background/aim: Irritable bowel syndrome (IBS) is a gastrointestinal condition characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause. This trial investigated the presence of microscopic colitis (MC) and associated factors related to MC in patients diagnosed with IBS. Materials and methods: The study group (group I) consisted of 91 consecutive patients diagnosed with IBS based on the Rome III Criteria for whom colonoscopic examination was requested. The control group (group II) had 41 patients diagnosed with IBS considered as eligible for colonoscopic investigation due to specific conditions, and for whom …
The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay
The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: Healthcare workers (HCWs) run the risk of hepatitis B virus (HBV) infection. Studies investigating the HBV and hepatitis C virus (HCV) serology of HCWs have been generally conducted in secondary or tertiary hospitals. In this study we aimed to determine the relationships between education level and HBV and HCV serology and HBV vaccination status of ambulance attendants. Materials and methods: The data of this study were obtained by retrospective review of ambulance personnel files in Sakarya Province, Turkey. Results: Out of 314 ambulance attendants, 216 (68.7%; 78 males, 138 females) were enrolled in this study. The mean length of …
Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan
Trace Elements Levels In The Serum, Urine, And Semen Of Patients With Infertility, Hasan Sali̇h Sağlam, Hüseyi̇n Altundağ, Yavuz Tarik Ati̇k, Mustafa Şahi̇n Dündar, Öztuğ Adsan
Turkish Journal of Medical Sciences
Background/aim: Studies suggest that trace elements may have an adverse impact on male reproduction, even at low levels. We tried to investigate the relationships between these metals and semen quality in various body fluids among men with infertility. Materials and methods: A total of 255 samples of blood, semen, and urine were collected from 85 men suffering from infertility. Inductively coupled plasma-optical emission spectrometry was used for the determination of 22 trace elements. We compared the results of the semen parameters with the results of the element determinations. Results: Because of the high proportion of samples with values lower than …
Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t
Malondialdehyde And Nitric Oxide Levels And Catalase, Superoxide Dismutase, And Glutathione Peroxidase Levels In Maternal Blood During Different Trimesters Ofpregnancy And In The Cord Blood Of Newborns, Sevda Yüksel, Ayşe Arzu Yi̇ği̇t
Turkish Journal of Medical Sciences
Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods: Maternal blood samples were collected at 9?13, 22?26, and 36?40 weeks of gestation. Cord blood was collected at the time of delivery. Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the …
Human Papillomavirus: A Potential Risk Factor For Colorectal Carcinoma?, Ufuk Berber, Alpaslan Tanoğlu, Ahmet Zi̇ya Balta
Human Papillomavirus: A Potential Risk Factor For Colorectal Carcinoma?, Ufuk Berber, Alpaslan Tanoğlu, Ahmet Zi̇ya Balta
Turkish Journal of Medical Sciences
No abstract provided.
Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit
Pandemic H1n1 Igg Levels In Healthcare Workers, Viroj Wiwanitkit
Turkish Journal of Medical Sciences
No abstract provided.
Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan
Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan
Turkish Journal of Medical Sciences
Background/aim: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells. Materials and methods: A549 alveolar epithelial cells were divided into control, CS exposure, CAPE, and CS+CAPE treatment groups. Undiluted CS-exposed medium (100%) and three dilutions (50%, 25%, and 10%) of CS-exposed media were applied to cultured A549 cells, which were analyzed after 3 h of incubation. Viability was measured by MTT assay, the gene expressions were evaluated by real-time PCR, and spectrophotometric techniques were used for biochemical assessments. Results: While CS exposure markedly reduced …
Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu
Effect Of Pioglitazone, Quercetin, And Hydroxy Citric Acid On Vascular Endothelial Growth Factor Messenger Rna (Vegf Mrna) Expression In Experimentally Induced Nonalcoholic Steatohepatitis (Nash)*, Surapaneni Krishna Mohan, Vishnu Priya Veeraraghavan, Mallika Jainu
Turkish Journal of Medical Sciences
Background/aim: Vascular endothelial growth factor (VEGF) is associated with various ischemic and inflammatory diseases, and plays an important role in the development of liver fibrosis and hepatocarcinogenesis in nonalcoholic steatohepatitis (NASH). In this study, the comparative effect of pioglitazone, quercetin, and hydroxy citric acid on VEGF mRNA in experimentally induced NASH was investigated. Materials and methods: The experimental protocol consisted of five groups: control, NASH, NASH + pioglitazone, NASH + quercetin, and NASH + hydroxy citric acid. The VEGF mRNA expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR) analysis for all experimental groups, and the levels of VEGF …
Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu
Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu
Turkish Journal of Medical Sciences
Background/aim: The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey. We aimed to characterize genotype 4 infections in Kayseri by analyzing the demographic and laboratory data of 218 HCV RNA-positive, treatment-naive patients admitted to the Kayseri Training and Research Hospital in 2010 and 2011. Materials and methods: The distributions of sex, age, and viral loads of these patients with respect to HCV genotypes were analyzed. We also characterized the type 4 sequences at the subtype level. Randomly selected sera from 32 of the 72 genotype 4 patients from …
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Turkish Journal of Medical Sciences
Background/aim: The 2009 influenza A (H1N1) pandemic caused mild to severe illnesses and led to death in some cases. In this study, we aimed to evaluate the relationship between the serum D-dimer levels, CURB-65 scores, and the severity of pneumonia among patients with H1N1 infections. Materials and methods: Sixty-eight patients who had probable H1N1 infections were evaluated by clinical, radiological, and laboratory methods. The H1N1 strain was specified by reverse transcription-polymerase chain reaction. Of 55 patients diagnosed with pneumonia, 18 exhibited H1N1 positivity and 37 patients did not. Results: CURB-65 scores of pneumonia patients with H1N1 (group 1) were higher …
Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t
Comparison Of The Contamination Rates Of Culture Media Used For Isolation And Identification Of Dermatophytes, Ramazan Gümral, Ayli̇n Döğen, Mehmet Maci̇t İlki̇t
Turkish Journal of Medical Sciences
Background/aim: Mycological media that promote spore production are essential for the diagnosis of dermatophytosis. However, these culture media frequently become contaminated by multiple fungal or bacterial species during culture. The aim of this study was to compare the contamination rates of 6 culture media used for the isolation and identification of dermatophytes, including Borelli's lactritmel agar (BLA), brain-heart infusion agar (BHIA), Lowenstein-Jensen agar (LJA), malt extract agar (MEA), potato dextrose agar (PDA), and Sabouraud glucose agar (SGA). Materials and methods: Agar plates were inoculated with 43 well-characterized dermatophyte strains, belonging to the genera Arthroderma, Epidermophyton, Microsporum, or Trichophyton. The agar …
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Turkish Journal of Medical Sciences
Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and …
Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi
Correlation Between Serum Levels Of Vitamin B12 And Anti-Helicobacter Pyloriiga Antibodies In Vitamin B12 Deficient Palestinian Patients, Rasmi Abu Hilu, Osama Dudeen, Sameer Abdullatif Barghouthi
Turkish Journal of Medical Sciences
Background/aim: H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori. Materials and methods: The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine. Results: There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 …
Sp1 Binding Site Polymorphism Of A Collagen Gene (Rs 1800012) In Womenaged 45 And Over And Its Association With Bone Density, Morteza Dehghan, Razieh Pourahmad-Jaktaji
Sp1 Binding Site Polymorphism Of A Collagen Gene (Rs 1800012) In Womenaged 45 And Over And Its Association With Bone Density, Morteza Dehghan, Razieh Pourahmad-Jaktaji
Turkish Journal of Medical Sciences
Background/aim: Sp1 polymorphism of type I collagen genes is accompanied with bone c??ollagen disorders and severe clinical phenotypes such as osteogenesis imperfecta. The aim of this study was to study the association between COLIA1 Sp1 polymorphism and bone density rate. Materials and methods: In this descriptive, analytical study conducted in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol-chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method. Results: The genotype distribution …
The Hematologic Manifestations Of Pediatric Celiac Disease At The Time Ofdiagnosis And Efficiency Of Gluten-Free Diet, Ferat Çatal, Erdem Topal, Hali̇me Ermi̇şteki̇n, Nurdan Yildirim Acar, Muhammed Selçuk Si̇nanoğlu, Hamza Karabi̇ber, Mukadder Ayşe Seli̇moğlu
The Hematologic Manifestations Of Pediatric Celiac Disease At The Time Ofdiagnosis And Efficiency Of Gluten-Free Diet, Ferat Çatal, Erdem Topal, Hali̇me Ermi̇şteki̇n, Nurdan Yildirim Acar, Muhammed Selçuk Si̇nanoğlu, Hamza Karabi̇ber, Mukadder Ayşe Seli̇moğlu
Turkish Journal of Medical Sciences
Background/aim: To determine the hematologic manifestations at the time of diagnosis of celiac disease in children and the effects of a gluten-free diet on hematologic signs upon follow-up. Materials and methods: The records of patients with celiac disease who received a follow up examination at the Pediatric Gastroenterology Clinic between June 2006 and June 2013 were retrospectively examined. Results: Ninety-one patients were included in the study. The mean age at diagnosis was 8.1 ± 4.21 years and 59 patients (64.8%) were female. Thirty-two patients (35.2%) had hematologic signs at the time of diagnosis. Anemia (24.2%) was the most common hematologic …
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Turkish Journal of Medical Sciences
Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, …
Efficacy Of Wound Infiltration With Lornoxicam For Postoperative Analgesiafollowing Thyroidectomy: A Prospective, Randomized, Double-Blind Study, Zafer Kilbaş, Mustafa Öner Menteş, Ali̇ Harlak, Taner Yi̇ği̇t, Sali̇h Müjdat Balkan, Ahmet Coşar, Erkan Öztürk, Orhan Kozak, Cemi̇l Turgut Tufan
Efficacy Of Wound Infiltration With Lornoxicam For Postoperative Analgesiafollowing Thyroidectomy: A Prospective, Randomized, Double-Blind Study, Zafer Kilbaş, Mustafa Öner Menteş, Ali̇ Harlak, Taner Yi̇ği̇t, Sali̇h Müjdat Balkan, Ahmet Coşar, Erkan Öztürk, Orhan Kozak, Cemi̇l Turgut Tufan
Turkish Journal of Medical Sciences
Background/aim: Postoperative pain control constitutes a major problem and studies have focused on reducing opioid requirements using regional techniques. We aimed to investigate the efficacy of wound infiltration with lornoxicam on postoperative pain control following thyroidectomy. Materials and methods: In this prospective, randomized-controlled study, 80 patients scheduled for thyroidectomy were randomly assigned to 2 groups. After the thyroidectomy was performed, patients in group I underwent wound infiltration with 4 mg of lornoxicam and patients in group II received the same amount of saline. Rescue analgesia was provided with additional doses of lornoxicam delivered by an on-demand patient-controlled analgesia device. Total …
Fetal Health Locus Of Control In A Sample Of Pregnant Turkish Women, Sevgi̇ Özcan, Veli̇ Duyan
Fetal Health Locus Of Control In A Sample Of Pregnant Turkish Women, Sevgi̇ Özcan, Veli̇ Duyan
Turkish Journal of Medical Sciences
Background/aim: To examine the relationship between sociodemographic and pregnancy features and fetal health locus of control (FHLC) in a sample of pregnant Turkish women. Materials and methods: The study was conducted with 256 pregnant women. Data were collected by demographic questionnaire and the FHLC Scale consisting of 3 components: 1) Internality Scale (FHLC-I), 2) Powerful Others Scale (FHLC-P), and 3) Chances Scale (FHLC-C). Results: The age of marriage was found to have a positive relation with FHLC-I (r = 0.141) and a negative relation with FHLC-C (r = -0.145) (P < 0.05). The age of first pregnancy was found to have a positive relation with FHLC-I (r = 0.127). Those who have a low educational level (r = -0.258) and income (r = -0.149), who are unemployed (r = -2.839), whose number of pregnancies is high (r = 0.152), who get pregnant unplanned (r = 3.839), and who come to their first prenatal examination late (r = -0.142) have a significantly high score of FHLC-C (P
Intrahepatic Cholestasis Of Pregnancy May Lead To Low Birth Weight, İbrahi̇m Uyar, İbrahi̇m Gülhan, Deni̇z Özteki̇n, Cenk Gezer, Atalay Eki̇n, Seçi̇l Karaca Kurtulmuş, Mehmet Özeren
Intrahepatic Cholestasis Of Pregnancy May Lead To Low Birth Weight, İbrahi̇m Uyar, İbrahi̇m Gülhan, Deni̇z Özteki̇n, Cenk Gezer, Atalay Eki̇n, Seçi̇l Karaca Kurtulmuş, Mehmet Özeren
Turkish Journal of Medical Sciences
Background/aim: To evaluate patients hospitalized in our clinic in the last 5 years with the diagnosis of intrahepatic cholestasis of pregnancy (ICP). Materials and methods: One hundred and fifty patients hospitalized with a diagnosis of ICP between January 2008 and May 2013 were evaluated retrospectively and age, week at diagnosis, gestational age at delivery, period between diagnosis and delivery, fetal weight, transaminases, and coagulation parameters were recorded. Patients were divided into groups according to their diagnosis weeks and gravida. Accordingly, patients diagnosed before 32 weeks formed group A (n = 49) and those after 32 weeks formed group B (n …
Distribution And Antifungal Resistance Of Candida Speciesisolated From Intensive Care Units, Pinar Korkmaz, Yeşi̇m Alpay, Fi̇gen Çevi̇k, Nevi̇l Aykin, Ayşe Koygun, Hakki Mustafa Güldüren
Distribution And Antifungal Resistance Of Candida Speciesisolated From Intensive Care Units, Pinar Korkmaz, Yeşi̇m Alpay, Fi̇gen Çevi̇k, Nevi̇l Aykin, Ayşe Koygun, Hakki Mustafa Güldüren
Turkish Journal of Medical Sciences
No abstract provided.
Myelodysplastic Features And Cellular Senescence In Autoimmune Disorders: A Pilot Study On Patients With Collagen Tissue Disorders And Immune Thrombocytopenic Purpura, Lale Olcay, Deni̇z Bi̇llur, Esra Erdemli̇, Sidika Esra Baskin, Havva Fatma Balci, Sevgi̇ Yetgi̇n
Myelodysplastic Features And Cellular Senescence In Autoimmune Disorders: A Pilot Study On Patients With Collagen Tissue Disorders And Immune Thrombocytopenic Purpura, Lale Olcay, Deni̇z Bi̇llur, Esra Erdemli̇, Sidika Esra Baskin, Havva Fatma Balci, Sevgi̇ Yetgi̇n
Turkish Journal of Medical Sciences
No abstract provided.
The Evaluation Of Transient Hypothyroidism In Patients Diagnosedwith Congenital Hypothyroidism, Havva Nur Peltek Kendi̇rci̇, Zehra Aycan, Eli̇f Sağsak, Meli̇kşah Keski̇n, Semra Çeti̇nkaya
The Evaluation Of Transient Hypothyroidism In Patients Diagnosedwith Congenital Hypothyroidism, Havva Nur Peltek Kendi̇rci̇, Zehra Aycan, Eli̇f Sağsak, Meli̇kşah Keski̇n, Semra Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: Congenital hypothyroidism (CH) is divided into two groups as 'permanent' and 'transient'. We aimed to determine the rate of transient and permanent congenital hypothyroidism of the newborns referred to our clinic. Materials and methods: Of the newborns who were referred to our clinic from the neonatal screening program, those who were diagnosed with CH and started treatment were included in the study. The treatments of the patients whose required daily treatment dose was reduced to under 1 µg/kg were terminated and those who were followed monthly and whose fT4 and thyroid-stimulating hormone (TSH) levels were normal at least 3 …