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Articles 3601 - 3630 of 8080
Full-Text Articles in Medicine and Health Sciences
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Turkish Journal of Medical Sciences
To evaluate the efficacy of entecavir (ETV) among chronic hepatitis B (CHB) nucleos(t)ide-naïve and -experienced patients in clinical practice. Materials and methods: In this retrospective study 85 CHB patients who had been receiving ETV and who attended our clinic since 2007 were included. Fifty patients were nucleos(t)ide analogue (NA)-naïve. Factors including sex, positive HBeAg, baseline HBV DNA level, baseline alanine aminotransferase level, and prior lamivudine (LAM) resistance were evaluated in terms of their predictive role in treatment response, which was defined as a serum HBV DNA decrease of
A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç
A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç
Turkish Journal of Medical Sciences
Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood. Materials and methods: Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week. Results: Glucose and …
Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez
Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez
Turkish Journal of Medical Sciences
To evaluate the predictive role of the circulating levels of vascular endothelial growth factor (VEGF) in gastric cancer patients. Materials and methods: This study is a case-control study. We measured serum VEGF levels of 30 patients aged between 34 and 83 years with gastric cancer and 30 patients without malignant pathology, operated on for benign pathologies, with ages ranging from 18 to 69. Results: Serum levels of VEGF were correlated with the tumor type classification (signet cell adenocarcinoma) and the presence of adjacent tissue invasion. There was also a positive correlation between serum VEGF and carcinoembryonic antigen levels. Conclusion: In …
Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu
Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu
Turkish Journal of Medical Sciences
To investigate the effect of positron emission tomography-computed tomography (PET/CT)-based contouring on dosimetric parameters in rectal cancer patients undergoing preoperative intensity-modulated radiation therapy (IMRT). Materials and methods: Preoperative radiation therapy plans with conformal radiotherapy (CRT) or IMRT were created and examined according to the CT- and PET/CT-based contouring of 20 rectal cancer patients, retrospectively. Results: The target volumes delineated with PET/CT were significantly larger than the volumes created by CT (P = 0.043). Dose delivered to 98% of the planning target volume was high in IMRT planning contouring with CT and PET/CT compared with CRT planning, but the difference was …
Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek
Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek
Turkish Journal of Medical Sciences
To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department. Materials and methods: The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted to the emergency department and 100 healthy control subjects. Results: Patients with acute coronary syndrome had significantly greater mean serum PAPP-A (patients, 10 ± 10 mIU/L; control subjects, 6 ± 10 mIU/L; P =< 0.001), procalcitonin (patients, 2 ± 10 µg/L; control subjects, 0.4 ± 2 µg/L; P =< 0.001), and troponin I levels (patients, 6 ± 8 µg/L; control subjects, 0.2 ± 0.3 µg/L; P =< 0.001) than control subjects. There was no difference in mean IMA levels between patients and control subjects. There were no significant correlations between PAPP-A levels and IMA, procalcitonin, or troponin I levels in patients with acute coronary syndrome. Conclusion: The PAPP-A, procalcitonin, and troponin I levels were increased in patients with acute coronary syndrome. Therefore, elevated PAPP-A and procalcitonin levels, in addition to troponin I levels, may be useful markers of myocardial injury on admission to the emergency department.
An Alternative Marker Of Low-Density Lipoprotein Cholesterol In Coronary Artery Disease: Non-High-Density Lipoprotein Cholesterol, Müjgan Ercan, Esra Oğuz, Fatma Meri̇ç Yilmaz, Ni̇hal Boğdaycioğlu, Kübranur Ünal, Deni̇z Şahi̇n, Sema Uysal
An Alternative Marker Of Low-Density Lipoprotein Cholesterol In Coronary Artery Disease: Non-High-Density Lipoprotein Cholesterol, Müjgan Ercan, Esra Oğuz, Fatma Meri̇ç Yilmaz, Ni̇hal Boğdaycioğlu, Kübranur Ünal, Deni̇z Şahi̇n, Sema Uysal
Turkish Journal of Medical Sciences
Dyslipidemia is one of the most important risk factors for coronary artery disease (CAD), and low-density lipoprotein cholesterol (LDL-C) is used to measure dyslipidemia. Non-high-density lipoprotein cholesterol (non-HDL-C) seems to be an alternative parameter to LDL-C as it is not influenced by triglyceride (TG) levels. The aim of this study is to compare non-HDL-C and LDL-C levels as risk markers in CAD patients. Materials and methods: One hundred and ten CAD patients and 42 individuals with normal coronary angiography results were included in this study. Patients were divided into 2 groups: TG < 200 mg/dL (n = 75) as group 1 and TG > 200 mg/dL (n = 35) as group 2. …
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Turkish Journal of Medical Sciences
Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism. Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance …
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Turkish Journal of Medical Sciences
To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or …
Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇
Is There An Association Between Histopathological Changes In The Lower Ureter And Renal Functions? Evaluation Of Patients Who Underwent Ureteroneocystostomy For Ureterovesical Obstruction Or Vesicoureteral Reflux, Müjdem Nur Azili, Doğuş Güney, Ayper Kaçar, Hüseyi̇n Tuğrul Ti̇ryaki̇
Turkish Journal of Medical Sciences
We aimed to assess the relationship between the histological changes of the ureterovesical junction (UVJ) and renal functions. Therefore, we evaluated histological changes of the lower ureter and renal scintigraphy findings of patients for whom ureteroneocystostomy was performed because of vesicoureteral reflux (VUR) or ureterovesical junction obstruction (UVO). Materials and methods: UVJ specimens were obtained from 18 children. We investigated the changes in neuronal innervation, muscular morphology, extracellular matrix, and apoptosis rate with renal scintigraphy findings. Results: Seven UVO and 11 VUR patients were treated. Alpha-actin expression in smooth muscle cells was found to be lower (P < 0.001) while neuronal defect was more prominent in the UVO group (P = 0.002). The renal functions decreased as the smooth muscle structural defect increased in the VUR group (P < 0.05). Conclusion: Neuronal tissue and muscle tissue were more defective in the UVO group. The decrease in neuronal fibers and muscle cells explains the pathogenesis of the obstructive group, but no difference was observed regarding the accumulation of collagen type 3 and cellular apoptosis between the VUR and UVO groups. In the VUR group, renal functions decreased while the smooth muscle defect at the distal end of the ureter increased.
The Protective Effect Of Syringic Acid On Ischemia Injury In Rat Brain, Mustafa Güven, Adem Bozkurt Aras, Naci̇ Topaloğlu, Adi̇le Özkan, Hali̇l Murat Şen, Yildiray Kalkan, Ali̇ Okuyucu, Ayla Akbal, Ferhat Gökmen, Murat Çoşar
The Protective Effect Of Syringic Acid On Ischemia Injury In Rat Brain, Mustafa Güven, Adem Bozkurt Aras, Naci̇ Topaloğlu, Adi̇le Özkan, Hali̇l Murat Şen, Yildiray Kalkan, Ali̇ Okuyucu, Ayla Akbal, Ferhat Gökmen, Murat Çoşar
Turkish Journal of Medical Sciences
Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. Materials and methods: The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic …
Oral Mucosal Lesions: A Retrospective Review Of One Institution’S 13-Year Experience, Burcu Sengüven, Emre Bariş, Benay Yildirim, Alaa Shuibat, Özlem Özer Yücel, Fari̇d Museyibov, Yeşi̇m Yildiz, Özkan Büyük, Si̇bel Eli̇f Gülteki̇n
Oral Mucosal Lesions: A Retrospective Review Of One Institution’S 13-Year Experience, Burcu Sengüven, Emre Bariş, Benay Yildirim, Alaa Shuibat, Özlem Özer Yücel, Fari̇d Museyibov, Yeşi̇m Yildiz, Özkan Büyük, Si̇bel Eli̇f Gülteki̇n
Turkish Journal of Medical Sciences
To investigate the relative frequency of biopsied nonneoplastic oral mucosal lesions in Ankara, Turkey. Materials and methods: Biopsy records of a single center from 2000-2012 were retrospectively collected. Diagnosis was recorded and evaluated with respect to patient demographics (age, sex) and location of the lesion. Results: Of 11,980 biopsies, 1732 (14.5%) were mucosal nonneoplastic lesions. Hyperplastic lesions (n = 1000, 57.7%) with fibroepithelial hyperplasia in 30.9% of patients were the most common type of oral nonneoplastic lesions. The mean age of patients differed with respect to type of mucosal lesion, tending to be lower in patients with reactive lesions. Dermatoses …
Acute Effect Of Hemodialysis On Arterial Elasticity, Sai̇m Sağ, Di̇lek Yeşi̇lbursa, Abdulmeci̇t Yildiz, Kami̇l Di̇lek, Tunay Şentürk, Osman Akin Serdar, Ali̇ Aydinlar
Acute Effect Of Hemodialysis On Arterial Elasticity, Sai̇m Sağ, Di̇lek Yeşi̇lbursa, Abdulmeci̇t Yildiz, Kami̇l Di̇lek, Tunay Şentürk, Osman Akin Serdar, Ali̇ Aydinlar
Turkish Journal of Medical Sciences
Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD. Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed …
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Protective Effects Of Erdosteine, Vitamin E, And Vitamin C On Renal Injury Induced By The Ischemia-Reperfusion Of The Hind Limbs In Rats, Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbaş, Soner Dönmez, Haci Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali
Turkish Journal of Medical Sciences
To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II …
Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li
Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li
Turkish Journal of Medical Sciences
To detect the effects on quinolone resistance due to biofilm formation activity in Ureaplasma urealyticum. Materials and methods: An improved checkerboard dilution susceptibility test was used to analyze the quinolone resistance of clinical Ureaplasma isolates and a postbiofilm formation susceptibility assay was used to compare the effects on the quinolone susceptibility between pre- and postbiofilm formations. Several important functional gene expressions were detected to evaluate their roles in the process of the quinolone resistance mechanism. Results: The quinolone-resistant isolates produced more biofilms than the sensitive isolates. In both the quinolone-resistant and -sensitive groups, the minimal inhibitory concentrations after biofilm formation …
Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak
Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak
Turkish Journal of Medical Sciences
To investigate the distribution of viral genotypes, the extrahepatic manifestations, and the relationship between genotypes and extrahepatic manifestations in patients with chronic hepatitis C. Materials and methods: The study included 62 treatment-naive patients with chronic hepatitis C infection. Genotype determination was performed by DNA sequencing analysis. To investigate extrahepatic manifestations, the patients' data, recorded prospectively during the pretreatment period, were analyzed. Results: Genotype determination was successful in 74.2% of the cases. All patients were infected with hepatitis C virus (HCV) genotype 1b. At least 1 extrahepatic manifestation was identified in 37.1% of the patients. The most frequent clinical manifestations were …
A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan
A Molecular Epidemiological Investigation Of Multistate Outbreaks Of Salmonella Enteritidis From Clinical And Environmental Samples In Turkey, 2000-2010, Sümeyra Acar, Belkis Levent, Ekrem Atalan
Turkish Journal of Medical Sciences
To analyze interrelated Salmonella Enteritidis strains isolated in Turkey. Fifty-five S. Enteritidis surveillance strains were isolated from human feces and environmental samples from different regions in Turkey between 2000 and 2010. Materials and methods: Clinical isolates were selected from different outbreaks in the Turkish National Reference Laboratory. All isolates were submitted to antimicrobial susceptibility test, plasmid profile analysis, and XbaI-digested pulsed-field gel electrophoresis. Results: The strains were scanned against 20 antibiotics and for 3 of them (amikacin, ciprofloxacin, gentamicin), all strains were found to be sensitive. Five isolates had no plasmid. Most of test strains carried the 57-kb plasmid in …
Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic
Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic
Turkish Journal of Medical Sciences
Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis-related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Materials and methods: Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences …
Clinicopathological Importance Of Ki-67, P27, And P53 Expression In Gastric Cancer, Muhammet Çalik, Eli̇f Demi̇rci̇, Eren Altun, İlknur Çalik, Özge Beyza Gündoğdu, Nesri̇n Gürsan, Betül Gündoğdu, Mevlüt Albayrak
Clinicopathological Importance Of Ki-67, P27, And P53 Expression In Gastric Cancer, Muhammet Çalik, Eli̇f Demi̇rci̇, Eren Altun, İlknur Çalik, Özge Beyza Gündoğdu, Nesri̇n Gürsan, Betül Gündoğdu, Mevlüt Albayrak
Turkish Journal of Medical Sciences
To assess the prognostic value of Ki-67, p27, and p53 immunoreactivity in human gastric cancer. Materials and methods: A total of 84 patients with gastric cancer participated in our study. We categorized tumors as intestinal and diffuse types, with reference to Lauren's classification. Ki-67, p27, and p53 immunoreactivity were correlated with patient's age, tumor type, grade, lymph node status, extent of invasion, tumor-node-metastasis (TNM) stage, and survival. Results: Decreased expression of p27 (50% positivity of cells) were determined in 41 (48.8%) and 29 (36.9%) tumor specimens, respectively, and were connected with both the TNM stage (P = 0.007 and P …
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Turkish Journal of Medical Sciences
To investigate cold-induced autoinflammatory syndrome 1 (CIAS1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP). Materials and methods: The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group. Results: The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A …
Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza
Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza
Turkish Journal of Medical Sciences
Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was …
Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru
Hypo- And Hypervolemic Edema In Children With Steroid Sensitive Nephrotic Syndrome, Mehmet Aki̇f Büyükavci, Mahmut Çi̇vi̇li̇bal, Murat Elevli̇, Hati̇ce Ni̇lgün Selçuk Duru
Turkish Journal of Medical Sciences
The mechanism of edema formation in nephrotic syndrome is still poorly understood. We aimed to evaluate the volume status in children with steroid-sensitive nephrotic syndrome (SSNS) and to emphasize the importance of echocardiography in demonstrating of volume changes. Materials and methods: Thirty-two SSNS patients and 30 healthy children were enrolled in this study. The volume statuses of patients were evaluated by clinical and laboratory features, including fractional sodium excretion (FENa) and distal sodium/potassium exchange (UK/UNa+K ratio). Inferior vena cava collapsibility index (IVCCI), left atrial diameter (LAD), aortic diameter (AD), and left ventricular mass index (LVMI) were measured using conventional echocardiographic …
The Long-Term Changes In Pain-Related Symptomatology Of Inguinal Hernia Following 2 Different Herniorrhaphy Techniques, Sali̇h Erpulat Özi̇ş, Işin Ünal Çevi̇k, Hati̇m Yahya Uslu, Süleyman Özdemi̇r, Kami̇l Gülpinar, Hasan Turgut Aydin
The Long-Term Changes In Pain-Related Symptomatology Of Inguinal Hernia Following 2 Different Herniorrhaphy Techniques, Sali̇h Erpulat Özi̇ş, Işin Ünal Çevi̇k, Hati̇m Yahya Uslu, Süleyman Özdemi̇r, Kami̇l Gülpinar, Hasan Turgut Aydin
Turkish Journal of Medical Sciences
To compare the changes in pain-related symptoms of inguinal hernias from initial admission to postoperative month 6 following 2 herniorrhaphy techniques. Materials and methods: Patients with unilateral inguinal hernias were scheduled for either Lichtenstein or self-gripping polypropylene mesh repair. Patients were preoperatively evaluated with a visual analog scale (VAS) and a Turkish version of the Douleur Neuropathique 4 (DN4) questionnaire and the complaints related to pain were noted. After surgery, patients were discharged without early complications. Patients were reassessed at postoperative month 6. The late-term complaints of pain as well as neurological findings were evaluated using the VAS and the …
Structural Chromosomal Abnormalities In Couples With Recurrent Abortion In Egypt, Nagwa E.A. Gaboon, Ahmed Ramy Mohamed, Solaf M. Elsayed, Osama K. Zaki, Mohamed A. Elsayed
Structural Chromosomal Abnormalities In Couples With Recurrent Abortion In Egypt, Nagwa E.A. Gaboon, Ahmed Ramy Mohamed, Solaf M. Elsayed, Osama K. Zaki, Mohamed A. Elsayed
Turkish Journal of Medical Sciences
To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis. Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed …
Aberrant Expression Of Leukemia Inhibitory Factor Receptor (Lifr) And Leukemia Inhibitory Factor (Lif) Is Associated With Tubal Pregnancy Occurrence, Yong Li, Lizhou Sun, Denmei Zhao, Jun Ouyang, Mei Xiang
Aberrant Expression Of Leukemia Inhibitory Factor Receptor (Lifr) And Leukemia Inhibitory Factor (Lif) Is Associated With Tubal Pregnancy Occurrence, Yong Li, Lizhou Sun, Denmei Zhao, Jun Ouyang, Mei Xiang
Turkish Journal of Medical Sciences
Tubal pregnancy is a major cause of maternal death in the first trimester and exploration of its underlying molecular mechanism is of great importance. This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues. Materials and methods: Immunohistochemistry was performed to probe the differential expression of LIF and LIFR in oviduct tissues among a control group (including NP group, n = 11; and IP group, n = 12), tubal pregnancy group (Ect-N group, n = 31; and Ect-A group, n = 40), and chronically inflamed …
The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak
The Effect Of Extracorporeal Shock Wave Lithotripsy On Distribution Of Interstitial Cells Of Cajal In Rabbit Renal Pelvis And Proximal Ureter, Özlem Boybeyi̇, Mi̇ne Fedakar Şenyücel, Ebru Şebnem Ayva, Tutku Soyer, Mustafa Kemal Aslan, Mehmet Murad Başar, Ahmet Murat Çakmak
Turkish Journal of Medical Sciences
An experimental study was performed to evaluate the effect of extracorporeal shock wave lithotripsy (ESWL) on the distribution of interstitial cells of Cajal (ICC) in rabbit renal pelvis and proximal ureter. Materials and methods: Six New Zealand rabbits were included. Right kidneys were exposed to a total of 3000 shock waves (14 kV) by using an electrohydraulic-type ESWL device. Right sides were allocated as the ESWL group (EG, n = 6) and left sides as the control group (CG, n = 6). Tissues were harvested on day 7. Tissues were examined histopathologically for the presence of edema, inflammation, congestion, hemorrhage, …
Comparison Of Perioperative Oxidative Stress In Endovascular And Open Repair Of Abdominal Aortic Aneurysm, Orhan Veli̇ Doğan, Ümi̇t Menteşe, Süheyla Doğan, Sefer Usta, İbrahi̇m Turan, Ergün Hali̇loğlu, Süleyman Caner Karahan
Comparison Of Perioperative Oxidative Stress In Endovascular And Open Repair Of Abdominal Aortic Aneurysm, Orhan Veli̇ Doğan, Ümi̇t Menteşe, Süheyla Doğan, Sefer Usta, İbrahi̇m Turan, Ergün Hali̇loğlu, Süleyman Caner Karahan
Turkish Journal of Medical Sciences
To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR). Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated. Results: OSI at …
Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv
Effect Of Keratinocyte Growth Factor On Growth And Transdifferentiationof Primary Alveolar Epithelial Type Ii Cells, Xiuxiang Liu, Zhichun Feng, Chunmei Tian, Xiangyong Kong, Yumei Wu, Changjun Lv
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of keratinocyte growth factor (KGF) on the growth and transdifferentiation of primary alveolar epithelial type II cells (AECIIs). Materials and methods: The number of primary AECIIs, their viability, and cell cycle and apoptosis were studied under KGF treatment using a hemocytometer, trypan blue exclusion, and flow cytometry, respectively. Positive expressions of surfactant protein C (SP-C), aquaporin 5 (AQP5), and thyroid transcription factor 1(TTF-1) were examined with indirect immunofluorescence; mRNA levels of SP-C, AQP5, and TTF-1 were determined by polymerase chain reaction. Results: In response to KGF treatment, cell numbers were significantly increased, more cells were …
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Protective Effect Of \Beta-Glucan On Acute Lung Injury Induced Bylipopolysaccharide In Rats, Meryem Iraz, Mustafa Iraz, Mukaddes Eşrefoğlu, Mehmet Şeri̇f Aydin
Turkish Journal of Medical Sciences
Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of \beta-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods: Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + \beta-glucan group (100 mg/kg \beta-glucan before LPS administration), and \beta-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive …
Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş
Vitamin E Modulates Lung Oxidative Stress, Serum Copper, Zinc, And Iron Levels In Rats With Pulmonary Contusion, Mehmet Sirmali, Okan Solak, Tali̇p Çevi̇k, Rana Sirmali, Bünyami̇n Özaydin, Zeynep Gi̇ni̇ş, Yetki̇n Ağaçkiran, Namik Deli̇baş
Turkish Journal of Medical Sciences
To evaluate the effects of oxidant/antioxidant mechanisms and levels of trace elements on trauma-stimulated moderate pulmonary contusions after vitamin E administration. Materials and methods: Sixty-three male Sprague Dawley rats were used. Animals were studied in 4 groups. Vitamin E (150 mg/kg) was injected intraperitoneally 30 min after trauma and on the first and second days. Blood samples were obtained for nitric oxide (NO) levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Zinc (Zn^{+2}), copper (Cu^{+2}), and iron (Fe^{+3}) were measured in serum. Results: Lung contusion increased serum and tissue NO levels and SOD activities and decreased GSH-Px activities …
Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan
Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan
Turkish Journal of Medical Sciences
Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I_2 (PGI_2) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells. Materials and methods: Human pulmonary alveolar epithelial cells (A549) were pretreated with 10 µM beraprost sodium 30 min before stimulation with 1 µg/mL LPS for 24 h. The cellular viability assessments were evaluated by quantitative MTT test. Catalase activity and glutathione and lipid peroxidation levels were determined using spectrophotometric techniques. mRNA expression analyses were …